Compact polyester artificial blood vessel

Abstract

The invention relates to a compact polyester artificial blood vessel which is characterized in that after polyester fibers are woven into tubular fabric, spiral lines are processed inside and outside the tubular fabric; the tubular fabric is characterized in that micropores of the tubular fabric are smaller than 10 microns. The woven micropores are controlled to be less than 10 microns, so that the water permeability of the whole blood vessel is ensured, namely a large amount of water cannot permeate, and cells can grow in the whole blood vessel. According to the artificial blood vessel, the water permeability can be well controlled, good biocompatibility is achieved, the single raw material (polyester fiber) is adopted, and therefore a coating does not need to be additionally arranged. Various risks caused by the coating are greatly reduced, namely, the risk of an animal source and the toxicity risk of other chemical additives, and the risk of thrombus caused by falling of the coating material in the long-term implantation process are greatly reduced.

Description

Technical Field

[0001] The invention relates to the technical field of textile biomaterials, in particular to a dense polyester artificial blood vessel. Background Art

[0002] Polyester woven artificial blood vessels were the earliest vascular materials used, and due to their high patency rate, they have long been successfully used for large blood vessel replacement. Then, the inside of the polyester woven artificial blood vessels needs to be coated with protein or gelatin coatings to prevent blood penetration in a short period of time. At the same time, the inner surface of the polyester blood vessels is rough, which easily activates the blood coagulation cascade reaction, causing the re-formation of blood clots.

[0003] Therefore, existing polyester artificial blood vessels need to be pre-coagulated or coated with collagen or gelatin to control water permeability. However, their drawbacks are:

[0004] (1) It can only prevent blood penetration for a short period of time.

[0005] (2) Risks from animal sources of coatings and toxicity risks from other chemical additives.

[0006] (3) The risk of thrombosis caused by the shedding of coating materials during long-term implantation is also extremely high. Summary of the Invention

[0007] The purpose of the present invention is to provide a dense polyester artificial blood vessel, which mainly solves the problems existing in the above-mentioned prior art. It is more conducive to long-term implantation in patients and greatly reduces various risks of the coating.

[0008] In order to achieve the above-mentioned object of the invention, the technical solution of the present invention is as follows:

[0009] A dense polyester artificial blood vessel is formed by weaving polyester fibers into a tubular fabric, and then processing spiral lines inside and outside the tubular fabric. The characteristic is that the micropores of the tubular fabric are smaller than 10 μm.

[0010] The dense polyester artificial blood vessel is characterized by:

[0011] When the diameter of the tubular fabric is ≤14mm, the spacing of the grain is 1±0.2mm, and the height of the grain is 0.5±0.2mm;

[0012] When the diameter of the tubular fabric is greater than 14 mm, the grain spacing is 2±0.2 mm and the grain height is 1±0.2 mm.

[0013] The dense polyester artificial blood vessel is characterized in that the polyester fiber uses polyester fibers with a fineness of 15D to 300D, and its microfilament part is 30F to 400F, that is, one polyester fiber is formed by combining 30 to 400 monofilament fibers.

[0014] The dense polyester artificial blood vessel is characterized in that the method of weaving the polyester fibers into a tubular fabric is as follows:

[0015] The polyester fiber is twisted to form S twist and Z twist, and the two fibers twisted in different directions are arranged side by side to form an entangled structure, that is, A combination;

[0016] Several A combinations are processed closely and in parallel on the beam head through the warping equipment, that is, B combination;

[0017] A combination A is wound onto a small shaft using a winding device, i.e., a combination C;

[0018] Place the B combination as the warp yarn head on the loom creel, and make the tension of the A combination in the B combination consistent with the tension between 2g-1200g to facilitate stable weaving; set the C combination on the weft yarn disc for weft weaving;

[0019] The tubular fabric is formed by weaving the B combination and the C combination.

[0020] The dense polyester artificial blood vessel is characterized in that the tubular fabric is woven with a warp density greater than 220 strands / cm and a weft density greater than 120 strands / cm.

[0021] The dense polyester artificial blood vessel is characterized in that the weaving structure of the tubular fabric is satin, plain, modified satin or modified plain.

[0022] The dense polyester artificial blood vessel is characterized in that the spiral patterns on the inside and outside of the tubular fabric are processed as follows:

[0023] Put the tubular fabric into a steel pipe with the same inner diameter as the fabric, insert the two ends of the steel pipe into the fixture of the pattern making machine, set the parameters of the pattern making machine, and start the pattern making and winding work.

[0024] The dense polyester artificial blood vessel is characterized in that the spiral patterns on the inside and outside of the tubular fabric are processed as follows:

[0025] A. providing a first graining line around a metal tube in an axial direction from a first end toward a second end in a spiral pattern;

[0026] B. putting a tubular fabric on the outer sleeve of the metal tube around which the first graining line is wound;

[0027] C. Winding a second graining line in a spiral pattern around the metal tube covered with the tubular fabric in an axial direction from the first end to the second end, with the second graining line being located between adjacent windings of the second graining line;

[0028] D. Remove the second graining line and remove the tubular fabric from the metal tube to form a dense polyester artificial blood vessel with spiral grains inside and outside.

[0029] The dense polyester artificial blood vessel is characterized in that the spiral patterns on the inside and outside of the tubular fabric are processed as follows:

[0030] a. Take a metal tube, the outer surface of the metal tube has a threaded protrusion extending in an axial direction from a first end to a second end;

[0031] b. Cover the metal tube with tubular fabric;

[0032] c. Winding a graining line around the metal tube covered with the tubular fabric in an axial direction from the first end to the second end in a spiral pattern, with the graining line being located between adjacent raised coils of the thread line;

[0033] d. Remove the graining line and remove the tubular fabric from the metal tube to form a dense polyester artificial blood vessel with spiral grains inside and outside.

[0034] In view of the above technical features, compared with the prior art, the present invention has the following advantages:

[0035] 1. The artificial blood vessel of the present invention adopts a special weaving structure, so that its weaving micropores are controlled at less than 10 μm, ensuring that the water permeability of the entire blood vessel is not excessive and that cells can grow in.

[0036] 2. Because the artificial blood vessel of the present invention can effectively control water permeability and has excellent biocompatibility, and is made of a single raw material (polyester fiber), it does not require additional coatings. This significantly reduces the risks associated with coatings, including risks from animal sources, toxicity from other chemical additives, and the risk of thrombosis caused by shedding of the coating material during long-term implantation.

[0037] 3. The spiral patterns on the inner and outer surfaces of the artificial blood vessels of the present invention enable the artificial blood vessels to have stretching and rebounding functions. BRIEF DESCRIPTION OF THE DRAWINGS

[0038] Figure 1 Schematic diagram of the structure of the dense polyester artificial blood vessel of the present invention;

[0039] Figure 2 It is a schematic structural diagram of combination A in the present invention;

[0040] Figure 3 This is a schematic diagram of the structure of S twist and Z twist in combination A;

[0041] Figure 4 It is a structural diagram of combination B in the present invention;

[0042] Figure 5 It is a schematic structural diagram of the C combination in the present invention;

[0043] Figure 6 The densely woven structure of the polyester artificial blood vessel of the present invention is developed under a 3D microscope.

[0044] Figure 7 This is the development of the existing polyester artificial blood vessel's woven structure under a 3D microscope.

[0045] Figure 8 This is a schematic diagram of the operating state of the graining device of the present invention. Figure 1 .

[0046] Figure 9 This is a schematic diagram of the operating state of the graining device of the present invention. Figure 2 . DETAILED DESCRIPTION

[0047] Below in conjunction with specific embodiment, further set forth the present invention.Should be understood that these embodiments are only used to illustrate the present invention and are not used in limiting the scope of the present invention.In addition, should be understood that after reading the content taught by the present invention, those skilled in the art can make various changes or modifications to the present invention, and these equivalent forms fall equally within the scope limited by the appended claims of the application.

[0048] See also Figure 1 The present invention discloses a dense polyester artificial blood vessel, which is formed by weaving polyester fibers into a tubular fabric, and then processing spiral patterns inside and outside the tubular fabric; the characteristic is that the micropores of the tubular fabric are less than 10um.

[0049] See also Figure 6 The product shown in the figure is a dense tubular fabric (artificial blood vessel) woven structure. Under a microscope, its light-transmitting point is tightly surrounded by fabric fibers. At a water pressure of 16KPa, the water content is less than 5ml / cm 2 , meeting the same water permeability requirements as coated blood vessels. Because the tubular fabric's pores are less than 10 μm, the light-transmitting gaps are significantly smaller, and the pore spacing and strand length and width are significantly reduced. This squeezes the fibers in the blood vessels more tightly within the same space, ultimately forming extremely dense interfiber gaps. Under the influence of water tension, this prevents water pressure from breaking through the fabric, effectively reducing water permeability to an acceptable range.

[0050] See also Figure 7 , the figure shows that Figure 6 The existing product of the same specification, namely the ordinary tubular fabric (artificial blood vessel), has a woven structure. Under a microscope, the light-transmitting fabric fibers cannot completely lock the micropores. At a water pressure of 16KPa, the water content is much greater than 5ml / cm 2Therefore, it is necessary to apply a coating such as protein or gelatin inside the artificial blood vessel to prevent blood from penetrating in a short period of time.

[0051] The dense polyester artificial blood vessel of the present invention has a groove spacing of 1±0.2mm and a groove height of 0.5±0.2mm when the tubular fabric diameter is ≤14mm; and a groove spacing of 2±0.2mm and a groove height of 1±0.2mm when the tubular fabric diameter is greater than 14mm.

[0052] In the present invention, the polyester fiber uses a polyester fiber with a fineness of 15D to 300D, and its microfilament part is 30F to 400F, that is, one polyester fiber is formed by combining 30 to 400 monofilament fibers.

[0053] like Figure 2-5 As shown, the method of weaving polyester fibers into tubular fabrics is as follows:

[0054] The polyester fiber is twisted to form S twist and Z twist, and the two fibers twisted in different directions are arranged side by side to form an entangled structure, that is, A combination 2, such as Figure 2 、 3 Among them: S twist and Z twist should maintain T / M300-600T / M

[0055] Several A combinations 2 are processed closely on the warping head 3 in parallel through the warping equipment 1, that is, B combinations, such as Figure 4 .

[0056] A combination 2 is wound on a small shaft 4 by a winding device, i.e., a C combination. Figure 5 .

[0057] The B combination is placed on the loom creel as the warp head, and the tension of the A combination in the B combination is made consistent with the tension between 2g-1200g to facilitate stable weaving; the C combination is set on the weft disk for weft weaving.

[0058] The tubular fabric is formed by weaving the B combination and the C combination.

[0059] The tubular fabric is woven with a warp density greater than 220 threads / cm and a weft density greater than 120 threads / cm.

[0060] Wherein: the weaving structure of the tubular fabric is satin, plain, modified satin or modified plain.

[0061] In the present invention, the spiral patterns on the inner and outer surfaces of the artificial blood vessels provide the artificial blood vessels with stretching and rebounding functions. The spiral patterns on the inner and outer surfaces of the tubular fabric are processed as follows:

[0062] The steps of method one are:

[0063] A. Figure 8 A first graining line 101 is wound around a metal tube 100 in an axial direction from a first end to a second end in a spiral pattern. During the winding process, a driving mechanism 102 drives the metal tube 100 to rotate, and a wire bundle forming the first graining line is released from a winding reel 103.

[0064] B. Putting tubular fabric 200 on the outer sleeve of the metal tube on which the first graining line is wound;

[0065] C. Figure 9 Then, a second graining line 104 is wound around the metal tube on which the tubular fabric 200 is sheathed in an axial direction from the first end to the second end in a spiral pattern, with the second graining line 104 being located between adjacent windings of the second graining line. During the winding process, the driving mechanism 102 drives the metal tube 100 to rotate, and the winding reel 103 releases the wire bundle forming the second graining line.

[0066] D. Remove the second graining line and remove the tubular fabric from the metal tube to form a dense polyester artificial blood vessel with spiral grains inside and outside.

[0067] The steps for method 2 are:

[0068] a. Take a metal tube, the outer surface of the metal tube has a threaded protrusion extending in an axial direction from a first end to a second end;

[0069] b. Cover the metal tube with tubular fabric;

[0070] c. Winding a graining line around the metal tube covered with the tubular fabric in an axial direction from the first end to the second end in a spiral pattern, with the graining line being located between adjacent raised coils of the thread line;

[0071] d. Remove the graining line and remove the tubular fabric from the metal tube to form a dense polyester artificial blood vessel with spiral grains inside and outside.

[0072] Both methods, one and two, involve inserting a tubular fabric into a metal tube of the same inner diameter. The metal tube is then fitted with a spiral protrusion extending axially from the first end to the second end. Graining wire is then wound around the tubular fabric in a spiral pattern, extending axially from the first end to the second end. The graining wire is wound between adjacent turns of the protrusion. This method overcomes the existing manual graining method of winding glass tubes, which suffers from slow processing, high learning costs, and inconsistent molding quality.

[0073] The above description is only a preferred embodiment of the present invention and does not limit the patent scope of the present invention. Any equivalent structure or equivalent process transformation made by using the contents of the present invention description and drawings, or directly or indirectly applied in other related technical fields, are also included in the patent protection scope of the present invention.

Claims

1. A dense polyester artificial blood vessel, which is made by weaving polyester fibers into a tubular fabric and then processing spiral patterns inside and outside the tubular fabric; characterized by: The micropores of the tubular fabric are smaller than 10 μm.

2. The dense polyester artificial blood vessel according to claim 1, characterized in that: When the diameter of the tubular fabric is ≤14mm, the spacing of the grain is 1±0.2mm, and the height of the grain is 0.5±0.2mm; When the diameter of the tubular fabric is greater than 14 mm, the grain spacing is 2±0.2 mm and the grain height is 1±0.2 mm.

3. The dense polyester artificial blood vessel according to claim 1, characterized in that: The polyester fiber uses polyester fibers with a fineness of 15D to 300D, and its microfilament portion is 30F to 400F, that is, one polyester fiber is formed by combining 30 to 400 monofilament fibers.

4. The dense polyester artificial blood vessel according to claim 1, 2 or 3, characterized in that: The method for forming a tubular fabric by weaving polyester fibers is as follows: The polyester fiber is twisted to form S twist and Z twist, and the two fibers twisted in different directions are arranged side by side to form an entangled structure, that is, A combination; Several A combinations are processed closely and in parallel on the beam head through the warping equipment, that is, B combination; A combination A is wound onto a small shaft using a winding device, i.e., a combination C; Place the B combination as the warp yarn head on the loom creel, and make the tension of the A combination in the B combination consistent with the tension between 2g-1200g to facilitate stable weaving; Set the C combination on the weft disc for weft weaving; The tubular fabric is formed by weaving the B combination and the C combination.

5. The dense polyester artificial blood vessel according to claim 4, characterized in that: The tubular fabric is woven with a warp density greater than 220 threads / cm and a weft density greater than 120 threads / cm.

6. The dense polyester artificial blood vessel according to claim 4, characterized in that: The weave structure of the tubular fabric is satin, plain, modified satin or modified plain.

7. The dense polyester artificial blood vessel according to claim 1, 2 or 3, characterized in that: The method of processing the spiral pattern inside and outside the tubular fabric is as follows: A. providing a first graining line around a metal tube in an axial direction from a first end toward a second end in a spiral pattern; B. putting a tubular fabric on the outer sleeve of the metal tube around which the first graining line is wound; C. Winding a second graining line in a spiral pattern around the metal tube covered with the tubular fabric in an axial direction from the first end to the second end, with the second graining line being located between adjacent windings of the second graining line; D. Remove the second graining line and remove the tubular fabric from the metal tube to form a dense polyester artificial blood vessel with spiral grains inside and outside.

8. The dense polyester artificial blood vessel according to claim 1, 2 or 3, characterized in that: The method of processing the spiral pattern inside and outside the tubular fabric is as follows: a. Take a metal tube, the outer surface of the metal tube has a threaded protrusion extending in an axial direction from a first end to a second end; b. Cover the metal tube with tubular fabric; c. Winding a graining line around the metal tube covered with the tubular fabric in an axial direction from the first end to the second end in a spiral pattern, with the graining line being located between adjacent raised coils of the thread line; d. Remove the graining line and remove the tubular fabric from the metal tube to form a dense polyester artificial blood vessel with spiral grains inside and outside.

Images