Multifunctional wound dressing medical material and application thereof

Abstract

The invention discloses a multifunctional wound dressing medical material which is of a three-layer composite structure composed of an outer protective film, a middle functional layer and an inner adhesion layer. The outer-layer protective film is formed by a medical-grade TPU (thermoplastic polyurethane) film and is used for isolating pollution and providing waterproof and breathable protection; the middle functional layer is composed of a self-healing hydrogel matrix, an environment response type nano-drug carrier, a flexible sensor module, a microfluidic cleaning network and an energy collection device are embedded in the self-healing hydrogel matrix, real-time monitoring and intelligent regulation and control of the local environment of the wound are achieved through a closed-loop control system, and drug release and cleaning operation are adjusted; the inner adhesion layer is made of a medical adhesive based on chitosan, so that the material is firmly attached to a wound, and secondary wound is prevented. The material can effectively reduce the infection risk and promote wound healing, and is suitable for postoperative and various wound nursing.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to a multifunctional wound dressing medical material and application thereof. Background Art

[0002] Wound care currently holds a crucial position in the medical field, with various dressings and medical materials widely used in wound management procedures, including surgery, chronic ulcers, and burns. These materials primarily serve to isolate external contaminants, maintain a local moist environment, and provide physical protection for wounds. Related technologies encompass a variety of materials, including medical films, hydrogels, and adhesives, as well as corresponding manufacturing methods and application techniques. The underlying principle is to achieve basic wound protection through the physical and chemical properties of the materials themselves.

[0003] Currently, wound dressings commonly used in clinical practice mostly utilize traditional materials and simple structures, primarily focusing on physical isolation, secretion absorption, and providing a localized moist environment. These materials often fail to integrate intelligent monitoring, precise drug release, and active cleaning functions, resulting in limitations in meeting the complex demands of wound management. Existing technologies for wound environment monitoring, sustained drug release, and active intervention measures are still in the exploratory and initial application stages, and a mature, systematic solution has yet to emerge.

[0004] Currently, the main technical challenge facing the medical community is how to achieve real-time monitoring of the local wound environment and precise control of drug release during wound care, while also avoiding secondary trauma caused by frequent dressing changes. This challenge places higher demands on the wound healing process and clinical care, but existing technologies have yet to effectively meet this need. Summary of the Invention

[0005] In order to solve the problems of the prior art, the present invention provides a multifunctional wound dressing medical material and its application. The technical solution is as follows:

[0006] On the one hand, a multifunctional wound dressing medical material is provided. The medical material is a three-layer composite structure, consisting of an outer protective film, an intermediate functional layer and an inner adhesion layer, wherein the outer protective film is used to isolate external pollution and provide waterproof and breathable protection; the intermediate functional layer has drug sustained release, environmental monitoring and active cleaning functions; the inner adhesion layer is used to make the medical material firmly adhere to the wound to prevent secondary trauma; the intermediate functional layer includes a nanodrug carrier, a flexible sensor module, a microfluidic cleaning network and an energy harvesting device. The functional modules work together through a closed-loop control system. When the local environment of the wound is abnormal, the closed-loop control system adjusts the drug release rate of the nanodrug carrier based on the real-time data collected by the flexible sensor module, and triggers the microfluidic cleaning network to release disinfectant, thereby overcoming the defects of the existing technology in terms of wound protection, continuous drug sustained release, active cleaning and real-time dynamic monitoring, such as untimely monitoring, uneven drug release and secondary trauma caused by frequent dressing changes.

[0007] Furthermore, the outer protective film is made of medical-grade thermoplastic polyurethane film, which is subjected to corona discharge treatment to form a uniform microporous structure on its surface, thereby providing excellent waterproof, antibacterial and breathable protection.

[0008] Furthermore, the intermediate functional layer comprises a self-healing hydrogel matrix, which is formed by blending polyvinyl alcohol and polyacrylamide in a fixed ratio and curing with ultraviolet light to form a continuous film. The film has high water content and self-healing function, ensuring long-term adhesion and stress repair.

[0009] Furthermore, the nano drug carrier embedded in the intermediate functional layer is prepared by a double emulsion method using a polylactic acid-glycolic acid copolymer and a polyethylene glycol diblock copolymer. The antibacterial drugs encapsulated therein are silver ions and iodophors, and a temperature- and pH-sensitive cross-linking agent is introduced, so that when the local temperature rises or the pH value decreases, the nano microcapsule wall partially degrades to accelerate drug release, and maintains a sustained release state during the normal wound healing stage.

[0010] Furthermore, the flexible sensor module embedded in the intermediate functional layer uses commercially available temperature sensors, humidity sensors and pH sensors, which are packaged in an ultra-thin flexible circuit board and arranged in a hydrogel matrix to collect local environmental parameters of the wound in real time and transmit the data to a closed-loop control system through a low-power wireless transmission device.

[0011] Furthermore, a microfluidic cleaning network is provided in the intermediate functional layer. The network uses laser engraving technology to form microchannels with a diameter of 50 to 200 microns in the hydrogel matrix, and is connected to a micro liquid storage tank pre-filled with medical-grade disinfectant. At the same time, a pH-sensitive microvalve is provided, which automatically opens when the local pH value is lower than a preset threshold to release disinfectant for active cleaning.

[0012] Furthermore, an energy harvesting device is provided in the intermediate functional layer. The device uses highly sensitive piezoelectric fibers arranged in a mesh pattern in the hydrogel to convert mechanical vibrations into electrical energy when the patient moves, and provides auxiliary power supply to the flexible sensor module and the wireless transmission device through the energy management module.

[0013] Furthermore, the closed-loop control system consists of a microcontroller and a low-power wireless transmission module. The microcontroller receives real-time environmental data collected by the flexible sensor module, and automatically adjusts the drug release rate of the nanodrug carrier according to a preset threshold, while triggering the microfluidic cleaning network to release disinfectant to achieve dynamic regulation of the local environment of the wound.

[0014] Furthermore, the inner adhesive layer is made of a chitosan-based medical adhesive, which has excellent biocompatibility and antibacterial properties, ensuring that the medical material fits firmly to the wound and preventing secondary trauma caused by dressing changes.

[0015] On the other hand, an application of a multifunctional wound dressing medical material is provided, which includes the following steps: after debridement and disinfection of the wound, covering the wound surface with the medical material so that the outer protective film isolates external pollution and provides waterproof and breathable protection; the nano-drug carrier embedded in the middle functional layer realizes sustained drug release according to changes in local temperature and pH value of the wound, the flexible sensor module collects local environmental data of the wound in real time, the microfluidic cleaning network automatically releases medical-grade disinfectant when the local pH value is lower than a preset threshold, and the energy harvesting device converts the mechanical vibration generated by the patient's body movement into electrical energy to supply a closed-loop control system. The closed-loop control system automatically adjusts the drug release rate and cleaning operation according to real-time monitoring data, thereby promoting wound healing, reducing the risk of infection, and avoiding secondary trauma caused by frequent dressing changes.

[0016] The technical solution provided by the embodiment of the present invention has the following beneficial effects:

[0017] This invention utilizes a three-layer composite structure consisting of an outer protective film, a middle functional layer, and an inner adhesive layer, effectively integrating drug release, environmental monitoring, active cleaning, and energy harvesting technologies. The outer protective film isolates external contaminants and provides waterproof and breathable protection. The middle functional layer, embedded with nano-drug carriers, a flexible sensor module, a microfluidic cleaning network, and an energy harvester, enables real-time monitoring and dynamic regulation of the local wound environment through closed-loop control. Drug release and cleaning operations can be intelligently adjusted based on real-time data, thereby reducing infection risk, minimizing secondary trauma, and promoting wound healing. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the following briefly introduces the drawings required for use in the description of the embodiments. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.

[0019] Figure 1 This is a module schematic diagram of a multifunctional wound dressing medical material according to Example 1 of the present invention. DETAILED DESCRIPTION

[0020] To make the objectives, technical solutions and advantages of the present invention more clear, the embodiments of the present invention will be described in further detail below with reference to the accompanying drawings.

[0021] Example 1

[0022] This embodiment provides a multifunctional wound dressing medical material, such as Figure 1 As shown, it comprises an outer protective film, an intermediate functional layer, and an inner adhesive layer. The outer protective film is made of a TPU film with a uniform microporous structure after corona discharge treatment, which isolates external contaminants and provides waterproof and breathable protection. The intermediate functional layer is composed of a self-healing hydrogel matrix, embedded with an environmentally responsive nano-drug carrier, a flexible sensor module, a microfluidic cleaning network, and an energy harvesting device. These modules are linked through a closed-loop control system to achieve local wound environment monitoring, intelligent drug release, and active cleaning. The inner adhesive layer is made of a chitosan-based medical adhesive, which adheres tightly to the wound surface to prevent secondary trauma.

[0023] The multifunctional wound dressing medical material described in this embodiment is composed of a three-layer composite structure, including an outer protective film, a middle functional layer, and an inner adhesive layer. The structure and function of each layer are as follows:

[0024] The outer protective film is a medical-grade thermoplastic polyurethane (TPU) film with a thickness between 20 and 50 microns. The film's surface is treated using conventional corona discharge equipment to create a uniform microporous structure. This treatment enhances the film's breathability and antimicrobial properties, while also providing waterproof protection, effectively isolating it from external contaminants and creating a necessary physical barrier for wounds.

[0025] The intermediate functional layer is based on a self-healing hydrogel matrix, composed of a fixed ratio (e.g., 2:1) of polyvinyl alcohol (PVA) and polyacrylamide. After sufficient dissolution, an appropriate amount of crosslinking agent is added, and then cured in a UV light-curing device to form a continuous film with a thickness of 200 to 500 microns. This hydrogel matrix has high water content and self-healing properties, allowing it to repair itself even in the event of local mechanical deformation, thereby ensuring the long-term stable embedding and uniform distribution of the functional modules.

[0026] The following functional modules are evenly embedded in the hydrogel matrix, as follows:

[0027] 1. Environmentally responsive nanodrug carriers

[0028] Nanocapsules are prepared using a double-emulsion method using a poly(lactic-co-glycolic acid)-poly(ethylene glycol) diblock copolymer, with particle sizes controlled between 100 and 300 nanometers. Antimicrobial drugs encapsulated within the nanocapsules include silver ions and iodophors, and a temperature- and pH-sensitive crosslinker is introduced during the preparation process. When the local temperature rises or the pH drops, the nanocapsule wall partially degrades, accelerating drug release. During the normal wound healing phase, the drug is sustained, achieving a sustained and effective antimicrobial effect.

[0029] 2. Flexible sensor module

[0030] Commercially available temperature, humidity, and pH sensors were packaged on an ultra-thin flexible circuit board and then placed within the hydrogel matrix. This module can collect local environmental parameters of the wound in real time. This data is transmitted to a closed-loop control system via a low-power wireless transmission device, providing a basis for the system to determine the wound's condition.

[0031] 3. Microfluidic Cleaning Network

[0032] Laser engraving technology creates a network of microchannels with diameters ranging from 50 to 200 microns within the hydrogel matrix. This network is connected to a micro-reservoir pre-filled with medical-grade disinfectant. A pH-sensitive microvalve is installed within the channel. When the local pH value falls below a preset threshold, the valve automatically opens, releasing disinfectant to actively clean the wound and reduce the risk of infection.

[0033] 4. Energy harvesting device

[0034] Highly sensitive piezoelectric fibers are arranged in a mesh pattern within the hydrogel matrix. Mechanical vibrations generated by patient movement are converted into electrical energy. After passing through the energy management module, this energy is preferentially supplied to the flexible sensor module and wireless transmission device, ensuring long-term continuous operation of the system and reducing reliance on external power sources.

[0035] The inner adhesive layer utilizes a chitosan-based medical adhesive, which, after proper neutralization, forms an adhesive layer with excellent biocompatibility and antimicrobial properties. This adhesive layer directly contacts the wound surface, ensuring a secure fit between the medical material and the wound, and preventing secondary trauma caused by dressing displacement or frequent changes.

[0036] Each functional module works together through a closed-loop control system. This system consists of a conventional microcontroller and a low-power wireless transmission module. The microcontroller receives real-time environmental data from the flexible sensor module and automatically adjusts the release rate of the nano-drug carrier based on preset thresholds. It also triggers the microfluidic cleaning network to release disinfectant, achieving dynamic regulation of the local wound environment. If an abnormality occurs in the local environment (such as an abnormally high temperature or low pH), the system automatically responds to ensure continued protection and treatment of the wound.

[0037] In summary, this embodiment utilizes a three-layer composite structure consisting of an outer protective film, a middle functional layer, and an inner adhesive layer, combined with the combined effects of these functional modules to achieve physical wound protection, sustained drug release, active cleaning, and real-time monitoring. This overcomes the shortcomings of existing technologies, such as delayed monitoring, uneven drug release, and secondary trauma caused by frequent dressing changes. All manufacturing processes utilize conventional hospital equipment and proven technologies, resulting in simple, low-cost processes and easy clinical application.

[0038] Example 2

[0039] The application described in this embodiment uses the multifunctional wound dressing medical material described in Example 1 for wound treatment, and the application process is as follows:

[0040] First, the patient's wound undergoes routine debridement and disinfection to ensure the wound surface is free of obvious infection and contamination. Subsequently, the multifunctional wound dressing material is cut to the appropriate size based on the wound's size and shape. The inner adhesive layer is applied directly to the wound surface, ensuring a tight fit and preventing secondary trauma caused by dressing displacement. The outer protective film isolates the wound from external contaminants, provides waterproof and breathable protection, and maintains a suitable moist environment within the wound.

[0041] Nano-drug carriers embedded in the intermediate functional layer slowly release drugs based on real-time changes in the wound's local temperature and pH, providing sustained antibacterial and healing effects. The flexible sensor module collects real-time data on the wound's local temperature, humidity, and pH, and transmits this data to a closed-loop control system via a low-power wireless transmission device. The closed-loop control system makes decisions based on the real-time data it receives. If it detects an abnormal local environment (such as an abnormally high temperature or low pH), it automatically instructs the nano-drug carriers to accelerate drug release and simultaneously triggers the microfluidic cleaning network to release a pre-set medical-grade disinfectant to actively clean the wound, thereby reducing the risk of infection.

[0042] Furthermore, the energy harvesting device converts the mechanical vibrations generated by the patient's movements into electrical energy, providing auxiliary power for the closed-loop control system and sensor module, ensuring long-term stable operation of the system. Through the above operations, the multifunctional wound dressing medical material achieves physical protection of the wound, continuous drug release, active cleaning, and real-time monitoring, thereby promoting wound healing, reducing the risk of infection, and avoiding secondary trauma caused by frequent dressing changes. This application solution is simple to operate and is suitable for postoperative wound care, chronic ulcer management, burn and trauma treatment, and has good clinical application prospects.

[0043] The above are only preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A multifunctional wound dressing medical material, characterized in that: This medical material has a three-layer composite structure, consisting of an outer protective film, an intermediate functional layer and an inner adhesion layer. The outer protective film is used to isolate external pollution and provide waterproof and breathable protection; the intermediate functional layer has drug sustained release, environmental monitoring and active cleaning functions; the inner adhesion layer is used to make the medical material firmly adhere to the wound to prevent secondary trauma; the intermediate functional layer includes nano drug carriers, flexible sensor modules, microfluidic cleaning networks and energy harvesting devices. The functional modules work together through a closed-loop control system. When the local environment of the wound is abnormal, the closed-loop control system adjusts the drug release rate of the nano drug carrier based on the real-time data collected by the flexible sensor module, and triggers the microfluidic cleaning network to release disinfectant.

2. The multifunctional wound dressing medical material according to claim 1, characterized in that: The outer protective film is made of medical-grade thermoplastic polyurethane film, and a uniform microporous structure is formed on the surface of the film after corona discharge treatment.

3. The multifunctional wound dressing medical material according to claim 1, characterized in that: The intermediate functional layer comprises a self-healing hydrogel matrix, which is formed by mixing polyvinyl alcohol and polyacrylamide in a fixed ratio and curing with ultraviolet light to form a continuous film.

4. The multifunctional wound dressing medical material according to claim 1, characterized in that: The nano drug carrier embedded in the intermediate functional layer is prepared by a double emulsion method using a polylactic acid-co-glycolic acid copolymer and a polyethylene glycol diblock copolymer. The antibacterial drugs encapsulated therein are silver ions and iodophors. A temperature- and pH-sensitive cross-linking agent is introduced so that when the local temperature rises or the pH value decreases, the nano microcapsule wall partially degrades to accelerate drug release, and maintains a sustained release state during the normal wound healing stage.

5. The multifunctional wound dressing medical material according to claim 1, characterized in that: The flexible sensor module embedded in the intermediate functional layer uses commercially available temperature sensors, humidity sensors and pH sensors, which are packaged in an ultra-thin flexible circuit board and arranged in a hydrogel matrix to collect local environmental parameters of the wound in real time and transmit the data to a closed-loop control system through a low-power wireless transmission device.

6. The multifunctional wound dressing medical material according to claim 1, characterized in that: A microfluidic cleaning network is provided in the intermediate functional layer. The microfluidic cleaning network uses laser engraving technology to form microchannels with a diameter of 50 to 200 microns in the hydrogel matrix, and is connected to a micro liquid storage tank pre-filled with medical-grade disinfectant. At the same time, a pH-sensitive microvalve is provided, which automatically opens when the local pH value is lower than a preset threshold to release disinfectant for active cleaning.

7. The multifunctional wound dressing medical material according to claim 1, characterized in that: An energy harvesting device is provided in the intermediate functional layer. The device uses highly sensitive piezoelectric fibers arranged in a mesh pattern in the hydrogel to convert mechanical vibrations into electrical energy when the patient moves, and provides auxiliary power supply to the flexible sensor module and wireless transmission device through the energy management module.

8. The multifunctional wound dressing medical material according to claim 1, characterized in that: The closed-loop control system consists of a microcontroller and a low-power wireless transmission module. The microcontroller receives real-time environmental data collected by the flexible sensor module and automatically adjusts the release rate of the nanodrug carrier according to a preset threshold. At the same time, it triggers the microfluidic cleaning network to release disinfectant to achieve dynamic regulation of the local wound environment.

9. The multifunctional wound dressing medical material according to claim 1, characterized in that: The inner adhesive layer is made of a chitosan-based medical adhesive with excellent biocompatibility and antibacterial properties, ensuring that the medical material adheres firmly to the wound and preventing secondary trauma caused by dressing changes.

10. Application of a multifunctional wound dressing medical material, characterized in that: The application of the multifunctional wound dressing medical material defined in claims 1 to 9 to treat a wound comprises the following steps: After the wound is cleaned and disinfected, the medical material is covered on the wound surface so that the outer protective film isolates external contamination and provides waterproof and breathable protection; The nano-drug carriers embedded in the middle functional layer achieve sustained drug release based on changes in local temperature and pH value of the wound. The flexible sensor module collects local environmental data of the wound in real time. The microfluidic cleaning network automatically releases medical-grade disinfectant when the local pH value is lower than the preset threshold. The energy harvesting device converts the mechanical vibrations generated by the patient's body movement into electrical energy to supply the closed-loop control system. The closed-loop control system automatically adjusts the drug release rate and cleaning operation based on real-time monitoring data.

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