Chewable tablet containing plant extract and preparation method thereof

Abstract

The invention relates to the technical field of chewable tablets, and discloses a chewable tablet containing a plant extract and a manufacturing method thereof.The chewable tablet is prepared from the following raw materials: a composite plant extract, a sweetening agent, an acidulant, magnesium stearate, silicon dioxide, dextrin, microcrystalline cellulose and nutrients. The traditional Chinese medicine composition can effectively prevent and treat oral diseases, promote repair and regeneration of damaged tissues, is beneficial to growth of effective microbial communities in the oral cavity, has an obvious inhibition effect on harmful pathogenic bacteria in the oral cavity, can effectively prevent and treat decayed teeth and periodontal diseases, has an obvious anti-inflammatory effect, can relieve gingivitis, periodontitis and the like, and is safe and reliable. The oral liquid also has the effects of clearing heat and drying dampness, reducing bitter taste and ozostomia, freshening breath and relieving poor taste, has good stability and broadens the range of audiences.

Description

Technical Field

[0001] The present invention relates to the technical field of chewable tablets, and in particular to a chewable tablet containing a plant extract and a manufacturing method thereof. Background Art

[0002] With the continuous improvement of living standards, people consume a large amount of high-sugar, high-nutrition foods. Due to the fast pace of life and the development of bad habits, people neglect their oral health. Food residues become a "breeding ground" for oral bacteria, leading to the rapid proliferation of oral bacteria and increasing the risk of oral diseases. Common oral diseases include periodontal disease, gum disease, bad breath, oral ulcers, and dental caries. Most of them are caused by ecological imbalance of normal oral flora, which leads to inflammation. Western medicine uses antibiotics to treat oral diseases. Antibiotics have toxic side effects on the human body and may also cause a decrease in the human immune system and cause other diseases. Plant extracts, on the other hand, generally contain a variety of substances with antibacterial, anti-inflammatory, and antioxidant activities. They are harmless to the human body and can effectively improve oral health, inhibit the growth and reproduction of harmful bacteria in the mouth, and maintain oral health. Chewable tablets are easy to take and can be taken without water. Therefore, they are suitable for the elderly, children, and people with swallowing difficulties. After chewing, the surface area of ​​the chewable tablet is increased, which is conducive to the dispersion and absorption of the drug in the mouth. Chewable tablets have high bioavailability. Therefore, the preparation of chewable tablets for preventing or treating oral diseases is of great practical significance.

[0003] Patent publication number CN113546137B discloses a pharmaceutical composition for treating or preventing oral diseases. The pharmaceutical composition contains bamboo leaf extract, mulberry leaf extract, lotus leaf extract, and scutellaria baicalensis extract. The pharmaceutical composition can be used in oral care products, health products, medicines, and plant beverages. It can be used to prevent, improve, or treat oral diseases such as periodontitis, oral ulcers, gingivitis, and oral odor. By utilizing different medicinal mechanisms and combining them in specific proportions, the synergistic effect between the components is fully utilized to have a significant inhibitory effect on oral disease pathogens, can remove oral odor, has a good taste, has little oral irritation, and is highly safe for long-term consumption. Therefore, the plant extracts can be used to prepare chewable tablets for preventing or treating oral diseases. The present invention provides a chewable tablet containing plant extracts, which has a significant effect in preventing or treating oral diseases, is convenient to consume, and is highly safe. Summary of the Invention

[0004] In order to solve the problems mentioned in the background technology, the object of the present invention is to provide a chewable tablet containing plant extracts and a manufacturing method thereof.

[0005] The purpose of the present invention can be achieved through the following technical solutions: A chewable tablet containing plant extracts comprises the following raw materials in parts by weight: 20-30 parts of a compound plant extract, 6-8 parts of a sweetener, 4-6 parts of a sour agent, 2-6 parts of magnesium stearate, 3-6 parts of silicon dioxide, 10-15 parts of dextrin, 8-12 parts of microcrystalline cellulose, and 4-8 parts of nutrients.

[0006] Furthermore, the preparation method of the composite plant extract comprises the following steps: Step A: adding the plant extract and the emulsifier to deionized water, stirring at a stirring rate of 1000-1200 r / min for 15-30 minutes, then ultrasonically treating at an ultrasonic power of 120-160 W for 5-10 minutes, and finally homogenizing 2-4 times at a homogenization pressure of 30-40 MPa to obtain a plant extract emulsion; Step B: dissolving the collagen peptide in deionized water and stirring to mix uniformly to obtain a collagen peptide solution; adding the collagen peptide solution to the plant extract emulsion and stirring at a stirring rate of 600-800 r / min for 30-60 minutes to obtain a mixture; Step C: dissolving pectin in deionized water and stirring evenly to obtain a pectin solution, adding the pectin solution to the mixture, raising the temperature to 40-50° C., stirring at a stirring rate of 800-1000 r / min for 30-60 minutes, standing and assembling for 2-4 hours, separating the product, and drying to obtain a composite plant extract.

[0007] By adopting the above technical solution, the emulsifier and the plant extract form a uniform plant extract emulsion under the action of stirring, ultrasound and homogenization. The collagen peptide and the plant extract emulsion will collide and contact with each other under high-speed stirring conditions, generate hydrogen bonds, and combine. The collagen peptide is coated on the surface of the plant extract to form a mixture. The collagen peptide is positively charged in deionized water, and the pectin is negatively charged in deionized water. Under the action of stirring, the two can generate electrostatic adsorption and undergo electrostatic self-assembly to obtain a composite plant extract.

[0008] Furthermore, in step A, the plant extracts are Magnolia bark extract and Scutellaria baicalensis extract in a mass ratio of 1:0.8-1.2.

[0009] Furthermore, in step A, the emulsifier is Tween 80.

[0010] Furthermore, the sweetener is any one of stevia, xylitol or mannitol.

[0011] Furthermore, the acidulant is citric acid or vitamin C.

[0012] Furthermore, the nutrients are vitamin A and vitamin D in a mass ratio of 1:0.4-0.6.

[0013] A method for producing a chewable tablet containing a plant extract comprises the following steps: Step 1: After uniformly mixing the composite plant extract, sweetener, acidulant, dextrin, microcrystalline cellulose and nutrients, deionized water is slowly added at a material-liquid mass ratio of 8-10:1, and the mixture is stirred at a stirring rate of 200-500 r / min for 1-3 hours to obtain a mixed material; Step 2: Add silicon dioxide and magnesium stearate to the mixture, stir and mix, pass through an 18-20 mesh sieve to form wet granules, then dry with hot air, and use a tablet press to compress the granules to obtain chewable tablets.

[0014] Furthermore, in the second step, the hot air drying temperature is 45-55° C., and the drying time is 30-60 min.

[0015] Beneficial effects of the present invention: The collagen peptide in the composite plant extract prepared by the present invention has good biocompatibility and absorbability, can accelerate the disappearance of inflammation, promote the repair and regeneration of damaged tissues, and also has the effect of promoting the growth of beneficial bacteria in the oral cavity. The main components of the plant extract are phenols and flavonoids, which have a significant inhibitory effect on harmful pathogens in the oral cavity such as Streptococcus mutans, Actinomyces viscosus, and Prevotella intermedia, can effectively prevent caries and periodontal disease, have a significant anti-inflammatory effect, can alleviate gingivitis and periodontitis, and promote oral health. At the same time, it also has the effect of clearing heat and dampness, improving the hot and humid environment in the oral cavity, reducing the growth of harmful bacteria, and reducing the occurrence of bitter taste and bad breath. Pectin has good adhesion and film-forming properties, and can form a protective film in the mouth, thereby covering the damaged area, playing a protective role, and reducing further damage caused by external stimulation. The electrostatic adsorption of collagen peptides and pectin is used to encapsulate the plant extract emulsion, which is beneficial to the preservation of the active ingredients in the plant extract, avoiding oxidation or volatilization of the active ingredients under the influence of the external environment, and can improve stability. The coating can also increase the bioavailability of the active ingredients in the plant extract, making it easier to absorb. In addition, the coating technology also reduces the unpleasant taste of the plant extract, making it more acceptable, thereby broadening the audience of chewable tablets.

[0016] Of course, any product implementing the present invention does not necessarily need to achieve all of the advantages described above at the same time. DETAILED DESCRIPTION

[0017] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making any creative efforts are within the scope of protection of the present invention.

[0018] Example 1 Preparation of compound plant extracts Step A: 1 g of Magnolia officinalis extract, 1 g of Scutellaria baicalensis extract, and 5 g of Tween 80 emulsifier were added to deionized water, stirred at a stirring rate of 1000 r / min for 25 minutes, and then ultrasonically treated at an ultrasonic power of 140 W for 6 minutes. Finally, the mixture was homogenized three times at a homogenization pressure of 35 MPa to obtain a plant extract emulsion; Step B: dissolving 2.6 g of collagen peptide in deionized water and stirring to obtain a collagen peptide solution with a concentration of 0.2%; adding the collagen peptide solution to the plant extract emulsion and stirring at a stirring rate of 800 r / min for 40 minutes to obtain a mixture; Step C: 3 g of pectin was dissolved in deionized water and stirred evenly to obtain a pectin solution with a concentration of 0.3%. The pectin solution was added to the mixture, the temperature was raised to 45°C, and the mixture was stirred at a stirring rate of 900 r / min for 50 minutes. After standing and assembling for 4 hours, the product was separated and dried to obtain a composite plant extract.

[0019] Example 2 A chewable tablet containing a plant extract comprises the following raw materials in parts by weight: 20 g of the composite plant extract prepared in Example 1, 6 g of stevia, 4 g of citric acid, 2 g of magnesium stearate, 3 g of silicon dioxide, 10 g of dextrin, 8 g of microcrystalline cellulose, 2.5 g of vitamin A, and 1.5 g of vitamin D.

[0020] The method for preparing the chewable tablet containing the plant extract comprises the following steps: Step 1: After uniformly mixing the composite plant extract, stevia, citric acid, dextrin, microcrystalline cellulose, vitamin A and vitamin D, deionized water was slowly added at a material-liquid mass ratio of 8:1, and the mixture was stirred at a stirring rate of 200 r / min for 1 hour to obtain a mixed material; Step 2: Add silicon dioxide and magnesium stearate to the mixture, stir and mix, pass through a 20-mesh sieve to form wet granules, then dry with hot air at a temperature of 45°C for 30 minutes, and use a tablet press to compress the granules to obtain chewable tablets.

[0021] Example 3 A chewable tablet containing a plant extract comprises the following raw materials in parts by weight: 22 g of the composite plant extract prepared in Example 1, 6.5 g of xylitol, 4.5 g of citric acid, 3 g of magnesium stearate, 3.5 g of silicon dioxide, 12 g of dextrin, 9 g of microcrystalline cellulose, 3.2 g of vitamin A, and 1.8 g of vitamin D.

[0022] The method for preparing the chewable tablet containing the plant extract comprises the following steps: Step 1: After uniformly mixing the composite plant extract, xylitol, citric acid, dextrin, microcrystalline cellulose, vitamin A and vitamin D, deionized water was slowly added at a material-liquid mass ratio of 8.5:1, and the mixture was stirred at a stirring rate of 250 r / min for 1.5 hours to obtain a mixed material; Step 2: Add silicon dioxide and magnesium stearate to the mixture, stir and mix, pass through a 20-mesh sieve to form wet granules, then dry with hot air at a temperature of 45° C. for 40 minutes, and use a tablet press to compress the granules to obtain chewable tablets.

[0023] Example 4 A chewable tablet containing a plant extract comprises the following raw materials in parts by weight: 25 g of the composite plant extract prepared in Example 1, 6.5 g of mannitol, 5 g of vitamin C, 3.5 g of magnesium stearate, 3.5 g of silicon dioxide, 12 g of dextrin, 9 g of microcrystalline cellulose, 3.8 g of vitamin A, and 2.2 g of vitamin D.

[0024] The method for preparing the chewable tablet containing the plant extract comprises the following steps: Step 1: After uniformly mixing the composite plant extract, mannitol, vitamin C, dextrin, microcrystalline cellulose, vitamin A, and vitamin D, deionized water was slowly added at a material-liquid mass ratio of 9:1, and the mixture was stirred at a stirring rate of 300 r / min for 2 hours to obtain a mixed material; Step 2: Add silicon dioxide and magnesium stearate to the mixture, stir and mix, pass through an 18-mesh sieve to form wet granules, then dry with hot air at a temperature of 45°C for 45 minutes, and use a tablet press to compress the granules to obtain chewable tablets.

[0025] Example 5 A chewable tablet containing a plant extract comprises the following raw materials in parts by weight: 26 g of the composite plant extract prepared in Example 1, 7.5 g of stevia, 5.5 g of vitamin C, 5 g of magnesium stearate, 5 g of silicon dioxide, 14 g of dextrin, 11 g of microcrystalline cellulose, 4.5 g of vitamin A, and 2.5 g of vitamin D.

[0026] The method for preparing the chewable tablet containing the plant extract comprises the following steps: Step 1: After uniformly mixing the composite plant extract, stevia, vitamin C, dextrin, microcrystalline cellulose, vitamin A, and vitamin D, deionized water was slowly added at a material-liquid mass ratio of 9.5:1, and the mixture was stirred at a stirring rate of 400 r / min for 2.5 hours to obtain a mixed material; Step 2: Add silicon dioxide and magnesium stearate to the mixture, stir and mix, pass through an 18-mesh sieve to form wet granules, and then dry with hot air at a temperature of 50° C. for 50 minutes. Use a tablet press to compress the granules to obtain chewable tablets.

[0027] Example 6 A chewable tablet containing a plant extract comprises the following raw materials in parts by weight: 30 g of the composite plant extract prepared in Example 1, 8 g of xylitol, 6 g of citric acid, 6 g of magnesium stearate, 6 g of silicon dioxide, 15 g of dextrin, 12 g of microcrystalline cellulose, 5 g of vitamin A, and 3 g of vitamin D.

[0028] The method for preparing the chewable tablet containing the plant extract comprises the following steps: Step 1: After uniformly mixing the composite plant extract, xylitol, citric acid, dextrin, microcrystalline cellulose, vitamin A and vitamin D, deionized water was slowly added at a material-liquid mass ratio of 10:1, and the mixture was stirred at a stirring rate of 500 r / min for 3 hours to obtain a mixed material; Step 2: Add silicon dioxide and magnesium stearate to the mixture, stir and mix, pass through an 18-mesh sieve to form wet granules, then dry with hot air at a temperature of 55° C. for 60 minutes, and use a tablet press to compress the granules to obtain chewable tablets.

[0029] Comparative Example 1 A chewable tablet containing a plant extract comprises the following raw materials in parts by weight: 25 g of the plant extract emulsion prepared in Example 1, 6.5 g of mannitol, 5 g of vitamin C, 3.5 g of magnesium stearate, 3.5 g of silicon dioxide, 12 g of dextrin, 9 g of microcrystalline cellulose, 3.8 g of vitamin A, and 2.2 g of vitamin D.

[0030] The method for preparing the chewable tablet containing the plant extract comprises the following steps: Step 1: After uniformly mixing the plant extract emulsion, mannitol, vitamin C, dextrin, microcrystalline cellulose, vitamin A and vitamin D, deionized water is slowly added at a material-liquid mass ratio of 9:1, and the mixture is stirred at a stirring rate of 300 r / min for 2 hours to obtain a mixed material; Step 2: Add silicon dioxide and magnesium stearate to the mixture, stir and mix, pass through an 18-mesh sieve to form wet granules, then dry with hot air at a temperature of 45°C for 45 minutes, and use a tablet press to compress the granules to obtain chewable tablets.

[0031] Comparative Example 2 A chewable tablet containing a plant extract comprises the following raw materials in parts by weight: 6.5g of mannitol, 5g of vitamin C, 3.5g of magnesium stearate, 3.5g of silicon dioxide, 12g of dextrin, 9g of microcrystalline cellulose, 3.8g of vitamin A and 2.2g of vitamin D.

[0032] The method for preparing the chewable tablet containing the plant extract comprises the following steps: Step 1: After mannitol, vitamin C, dextrin, microcrystalline cellulose, vitamin A and vitamin D are uniformly mixed, deionized water is slowly added at a material-liquid mass ratio of 9:1, and the mixture is stirred at a stirring rate of 300 r / min for 2 hours to obtain a mixed material; Step 2: Add silicon dioxide and magnesium stearate to the mixture, stir and mix, pass through an 18-mesh sieve to form wet granules, then dry with hot air at a temperature of 45°C for 45 minutes, and use a tablet press to compress the granules to obtain chewable tablets.

[0033] Detection a. Antibacterial testing The chewable tablets prepared in Examples 2 to 6 and Comparative Examples 1 to 2 were allowed to stand for 5 months and then crushed and added to deionized water to prepare a 1% chewable tablet solution. Actinomycetes viscosus, Prevotella intermedia, and Streptococcus mutans were added to phosphate buffer containing 1% peptone to prepare bacterial suspensions of equal concentration. The temperature was set at 35° C. 5 mL of each bacterial suspension was taken and 5 mL of the chewable tablet solution was added thereto. After shaking and incubating for 6 hours, the number of viable bacteria was counted and the antibacterial rate was calculated. The results are shown in the following table:

[0034] As can be seen from the above table, the chewable tablets prepared in Examples 2 to 6 of the present invention have excellent antibacterial and anti-inflammatory effects, with high inhibition rates. The highest inhibition rate for Actinomycetes viscosus is 95.8%, the highest inhibition rate for Prevotella intermedia is 94.6%, and the highest inhibition rate for Streptococcus mutans is 96.4%. Actinomycetes viscosus and Prevotella intermedia are pathogenic bacteria of pulp and periapical infections, and Streptococcus mutans is one of the pathogens of dental caries. It can be seen that the chewable tablets have a good inhibitory effect on pathogenic bacteria of oral diseases. In Comparative Example 1, the plant extract emulsion is directly added to prepare the chewable tablet. During the storage process, the active ingredient is easily volatilized or oxidized, so the antibacterial effect is poor. Comparative Example 2 does not contain plant extract and has a poor antibacterial effect.

[0035] b. Test on the therapeutic effect of oral ulcers Using healthy male rats that have just reached adulthood, the phenol cauterization method was used to model the model. The cauterized area formed a circular or oval ulcer with a diameter of about 5 mm, with redness and swelling around it, a rough and uneven mucosal surface, and reduced activity, drinking water, and food intake of the rats. This was considered a successful modeling. 80 male rats with successfully modeled oral ulcers were randomly divided into 8 groups, each with 10 rats. One group was the model group, and the remaining chewable tablets prepared in Examples 2 to 6 and Comparative Examples 1 to 2 were prepared into a solution, which was applied to the oral ulcer with a sterile cotton swab. The ulcer diameter was measured with a vernier caliper before the first treatment each day and recorded. The treatment was repeated 3 times a day with an interval of 5 h for 5 consecutive days until the ulcer healing test was completed. The test results are shown in the following table:

[0036] As can be seen from the above table, the chewable tablets prepared in Examples 2 to 6 of the present invention have a more obvious effect on the treatment of oral ulcers, can promote ulcer healing, and shorten the ulcer healing time. The chewable tablet prepared in Comparative Example 1 has no obvious effect on the treatment of oral ulcers, and the chewable tablet prepared in Comparative Example 2 has a poor effect on the treatment of oral ulcers.

[0037] c. Chewable tablet stability test The chewable tablets prepared in Examples 2 to 6 and Comparative Examples 1 and 2 were placed in an environment of 45° C. and 75% relative humidity. The appearance at the initial stage, on the 60th day, and on the 90th day was recorded, and the friability was tested. The friability test method was as follows: 6.5 g of chewable tablets were weighed, and the powder shed from the tablets was blown off with a hair dryer, and the tablets were accurately weighed. The tablets were placed in the cylinder of a tablet friability tester and rotated 100 times at 30 rpm. After being taken out, the powder shed from the tablets was blown off with a hair dryer, and the tablets were accurately weighed. The weight loss was calculated. The test results are shown in the following table:

[0038] As can be seen from the above table, the chewable tablets prepared in Examples 2 to 6 of the present invention have good stability and are stable under long-term test conditions, while the chewable tablet prepared in Comparative Example 1 has poor stability.

[0039] The above content is merely an example and explanation of the concept of the present invention. Those skilled in the art may make various modifications or additions to the described specific embodiments or replace them in a similar manner. As long as they do not deviate from the concept of the invention or exceed the scope defined by the claims, they should all fall within the scope of protection of the present invention.

Claims

1. A chewable tablet containing a plant extract, characterized in that: The invention comprises the following raw materials in parts by weight: 20-30 parts of compound plant extract, 6-8 parts of sweetener, 4-6 parts of acidulant, 2-6 parts of magnesium stearate, 3-6 parts of silicon dioxide, 10-15 parts of dextrin, 8-12 parts of microcrystalline cellulose and 4-8 parts of nutrients.

2. A chewable tablet containing a plant extract according to claim 1, characterized in that: The preparation method of the composite plant extract comprises the following steps: Step A: adding the plant extract and the emulsifier to deionized water, stirring at a stirring rate of 1000-1200 r / min for 15-30 minutes, then ultrasonically treating at an ultrasonic power of 120-160 W for 5-10 minutes, and finally homogenizing 2-4 times at a homogenization pressure of 30-40 MPa to obtain a plant extract emulsion; Step B: dissolving the collagen peptide in deionized water and stirring to mix uniformly to obtain a collagen peptide solution; adding the collagen peptide solution to the plant extract emulsion and stirring at a stirring rate of 600-800 r / min for 30-60 minutes to obtain a mixture; Step C: dissolving pectin in deionized water and stirring evenly to obtain a pectin solution, adding the pectin solution to the mixture, raising the temperature to 40-50° C., stirring at a stirring rate of 800-1000 r / min for 30-60 minutes, standing and assembling for 2-4 hours, separating the product, and drying to obtain a composite plant extract.

3. The chewable tablet containing a plant extract according to claim 2, characterized in that: In step A, the plant extracts are Magnolia bark extract and Scutellaria baicalensis extract in a mass ratio of 1:0.8-1.

2.

4. The chewable tablet containing a plant extract according to claim 2, wherein: In step A, the emulsifier is Tween 80.

5. The chewable tablet containing a plant extract according to claim 1, characterized in that: The sweetener is any one of stevia, xylitol or mannitol.

6. The chewable tablet containing plant extract according to claim 1, characterized in that: The acidulant is citric acid or vitamin C.

7. The chewable tablet containing a plant extract according to claim 1, characterized in that: The nutrients are vitamin A and vitamin D in a mass ratio of 1:0.4-0.

6.

8. A method for producing a chewable tablet containing a plant extract according to claim 1, characterized in that: The following steps are involved: Step 1: After uniformly mixing the composite plant extract, sweetener, acidulant, dextrin, microcrystalline cellulose and nutrients, deionized water is slowly added at a material-liquid mass ratio of 8-10:1, and the mixture is stirred at a stirring rate of 200-500 r / min for 1-3 hours to obtain a mixed material; Step 2: Add silicon dioxide and magnesium stearate to the mixture, stir and mix, pass through an 18-20 mesh sieve to form wet granules, then dry with hot air, and use a tablet press to compress the granules to obtain chewable tablets.

9. The method for producing a chewable tablet containing a plant extract according to claim 8, wherein: In the second step, the hot air drying temperature is 45-55° C., and the drying time is 30-60 minutes.

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