White hair blackening formula based on traditional Chinese medicine small molecule targeted delivery

Abstract

The invention discloses a formula for turning white hair into black hair based on traditional Chinese medicine micromolecule targeted delivery. The traditional Chinese medicine formula is prepared from the following raw material medicines: polygonum multiflorum, black sesame, ginseng, angelica sinensis, mulberry, eclipta, glossy privet fruit, cacumen biotae, lipidosome, a nano polymer, amino acid, vitamins and minerals. The invention relates to the technical field of traditional Chinese medicine formulas, in particular to a formula for turning white hair into black hair based on traditional Chinese medicine micromolecule targeted delivery, and due to the adoption of the technical scheme, the formula has the following advantages of synergistic interaction, accurate targeting, scientific proportioning, high safety, advanced process and controllable quality.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine formulas, and in particular to a formula for turning white hair into black hair based on targeted delivery of traditional Chinese medicine small molecules. Background Art

[0002] With the accelerated pace of life, increased mental stress and the intensification of population aging, the problem of gray hair has become an increasingly common health problem that plagues the public. The formation of gray hair is mainly closely related to the decline in the function and number of melanocytes in the hair follicles, or the obstruction of the melanin synthesis and metabolism pathway. Its inducements include genetic factors, aging process, nutritional deficiencies, chronic diseases and long-term mental stress. Among the traditional methods of turning gray hair into black, although chemical hair dyes can quickly change hair color, the chemical ingredients such as p-phenylenediamine they contain can easily cause skin allergies and irritate the respiratory tract. Long-term use even poses a potential carcinogenic risk. Although oral Chinese herbal preparations focus on overall conditioning, due to the lack of targeting, it is difficult for the drug to form an effective concentration locally in the hair follicles, resulting in a long treatment cycle and poor effect. Some topical products have low transdermal absorption efficiency and unstable active ingredients, making it difficult to deeply act on hair follicles and melanocytes, and the actual improvement effect is unsatisfactory. Therefore, a formula for turning gray hair into black based on the targeted delivery of small molecules from traditional Chinese medicine is proposed. Summary of the Invention

[0003] In view of this, the embodiments of the present invention hope to provide a formula for turning white hair black based on the targeted delivery of small molecules from traditional Chinese medicine to solve or alleviate the technical problems existing in the prior art and at least provide a beneficial option.

[0004] The purpose of the present invention can be achieved through the following technical measures: a formula for turning white hair into black hair based on targeted delivery of small molecules of traditional Chinese medicine, which is composed of the following raw materials: Polygonum multiflorum, black sesame, ginseng, angelica, mulberry, Eclipta prostrata, Ligustrum lucidum fruit, Platycladus orientalis leaves, liposomes, nanopolymers, amino acids, vitamins, and minerals.

[0005] The purpose of the present invention can also be achieved by the following technical measures:

[0006] The traditional Chinese medicine formula is composed of the following raw materials in parts by weight: 15-25 parts of Polygonum multiflorum, 10-20 parts of black sesame, 5-10 parts of ginseng, 8-12 parts of angelica, 12-18 parts of mulberry, 10-15 parts of Eclipta prostrata, 8-12 parts of Ligustrum lucidum fruit, 6-10 parts of Platycladus orientalis leaves, 0.5-5 parts of liposomes, 0.1-3 parts of nanopolymers, 2-6 parts of amino acids, 1-5 parts of vitamins, and 1-4 parts of minerals.

[0007] The purpose of the present invention can also be achieved by the following technical measures:

[0008] The liposomes, as drug carriers, can encapsulate small molecules of traditional Chinese medicine and improve their stability and targeting. The dosage needs to be determined according to the amount of active ingredients of the encapsulated traditional Chinese medicine and the specific targeting requirements.

[0009] The purpose of the present invention can also be achieved by the following technical measures:

[0010] The nanopolymer can precisely control drug release, and its dosage must take into account compatibility with other ingredients and its impact on drug delivery efficiency. The amino acid is an important raw material for synthesizing hair keratin, and tyrosine is also a precursor for melanin synthesis. Its dosage must meet the needs of normal hair growth and melanin synthesis.

[0011] The purpose of the present invention can also be achieved by the following technical measures:

[0012] The vitamins include B vitamins, vitamin C, and vitamin E, among which B vitamins may account for 0.5-2 parts, vitamin C accounts for 0.3-1.5 parts, and vitamin E accounts for 0.2-1 parts. Vitamins participate in the body's metabolism and play a certain role in maintaining hair follicle health and promoting melanin synthesis.

[0013] The purpose of the present invention can also be achieved by the following technical measures:

[0014] Among them, minerals participate in the regulation of the activity of multiple enzymes in the body and are of great significance to the maintenance of hair structure and function.

[0015] The purpose of the present invention can also be achieved by the following technical measures:

[0016] The formula is used to improve the problem of gray hair. Through the targeted effect of small molecules of traditional Chinese medicine, it may help promote the functional recovery of hair follicle cells, regulate the synthesis and secretion of melanin, and thus achieve the transformation of gray hair into black.

[0017] The purpose of the present invention can also be achieved by the following technical measures:

[0018] The steps for preparing the formula include:

[0019] S1. Pulverizing and extracting Chinese medicine: Pulverize Chinese medicine raw materials such as Polygonum multiflorum, black sesame, ginseng, angelica, mulberry, Ecliptae, Ligustrum lucidum, and Platycladus orientalis leaves, and pass them through a 60-100 mesh sieve for subsequent extraction. The effective ingredients of the Chinese medicine are extracted by percolation, and 60% by volume edible alcohol is used as the extraction solvent. The pulverized Chinese medicine raw materials are placed in a percolation cylinder, and soaked in an appropriate amount of solvent for 24 hours. The percolation is then slowly performed, and the percolation liquid is collected. The collected percolation liquid is concentrated using a rotary evaporator at 40-60° C. under reduced pressure to obtain a Chinese medicine extract concentrate;

[0020] S2. Nanocarrier preparation: Weigh appropriate amounts of liposomes and nanopolymers, dissolve the liposomes in chloroform, and dissolve the nanopolymers in methanol, then mix the two solutions to form a uniform mixture under magnetic stirring, and evaporate the mixture under reduced pressure on a rotary evaporator to remove the organic solvent, so that the liposomes and nanopolymers form a uniform thin film on the container wall, and add an appropriate amount of phosphate buffer to the container containing the film, and ultrasonicate at 30-40°C for 30-60 minutes to disperse the film to form a nanoscale liposome-nanopolymer complex suspension;

[0021] S3. Component mixing: Slowly add the concentrated Chinese herbal extract to the liposome-nanopolymer complex suspension while magnetically stirring at a speed of 300-500 rpm for 1-2 hours to allow the effective ingredients of the Chinese herbal medicine to be fully loaded onto the nanocarriers. Then, weighed vitamins, amino acids, and minerals are added in sequence and stirred for 30-60 minutes to allow them to be completely dissolved and mixed evenly.

[0022] S4. Lotion Forming: Adjust the volume and concentration of the mixed solution with deionized water to achieve the desired specifications of the lotion, such as a total volume of 100-500 ml, and adjust the pH value of the lotion to 5.5-7.5 with a pH regulator to adapt to the pH environment of the skin;

[0023] S5. Quality inspection and packaging: The lotion is quality inspected, including the use of high performance liquid chromatography to detect the content of effective ingredients of traditional Chinese medicine, dynamic light scattering to determine the particle size distribution of nanoparticles, and stability tests to examine the stability of the lotion under different temperature and light conditions. After passing the inspection, the lotion is filled into clean, sterile plastic bottles or glass bottles, sealed, and labeled with the product name, ingredients, instructions for use, shelf life and other information.

[0024] The purpose of the present invention can also be achieved by the following technical measures:

[0025] The entire preparation process must be carried out in an environment that complies with Good Manufacturing Practice (GMP) to ensure product quality and safety. At the same time, in actual production, process parameters can be optimized and adjusted according to specific circumstances.

[0026] The embodiment of the present invention adopts the above technical solution, which has the following advantages:

[0027] 1. Synergistic enhancement and precise targeting: The Chinese herbal ingredients in the formula work synergistically with vitamins, amino acids, and minerals to not only stimulate melanin synthesis, but also promote the proliferation of hair follicle stem cells and repair damaged cell structures. At the same time, they activate the body's antioxidant system, effectively scavenge ROS, and reduce oxidative damage to melanocytes. It improves the hair growth environment from multiple dimensions such as cell proliferation, metabolic regulation, and anti-oxidation, achieving the dual effects of turning gray hair black and maintaining healthy hair. In addition, it innovatively uses liposomes and nanopolymers as drug carriers to precisely encapsulate small molecule ingredients of Chinese herbal medicine such as Polygonum multiflorum and black sesame, which act on hair follicles and melanocytes in a targeted manner, efficiently activating the melanin production mechanism in gray hair and significantly improving the efficiency of pigmentation recovery. Compared with traditional formulas, the targeting and effect have achieved a qualitative leap.

[0028] 2. Scientific proportion and high safety: After rigorous screening and optimization, the weight ratio of each raw material is scientific and reasonable, which not only ensures the full efficacy of the drug, but also reduces the risk of interaction between ingredients. In addition, natural Chinese medicine and safe excipients are selected, without harmful additives such as chemical synthetic pigments and hormones. Through GMP standardized production and strict quality testing, we ensure stable product quality, high safety, and a wide range of applicability.

[0029] 3. Advanced technology and controllable quality: The percolation method is used to extract the active ingredients of traditional Chinese medicine, and nanocarriers are prepared by combining cutting-edge technologies such as thin film evaporation and ultrasonic dispersion to retain the active ingredients to the greatest extent and accurately control the particle size and drug loading rate of nanoparticles. Secondly, during the production process, key indicators are monitored in real time through high-performance liquid chromatography, dynamic light scattering and other technologies to achieve full-process quality control from raw materials to finished products, ensuring consistency and stability between product batches.

[0030] The above summary is for illustrative purposes only and is not intended to be limiting in any way. In addition to the illustrative aspects, embodiments and features described above, further aspects, embodiments and features of the present invention will be readily apparent by reference to the following detailed description. DETAILED DESCRIPTION

[0031] Hereinafter, only certain exemplary embodiments are briefly described. As will be appreciated by those skilled in the art, the described embodiments may be modified in various ways without departing from the spirit or scope of the present invention. Therefore, the description is considered to be illustrative and non-restrictive in nature.

[0032] It should be noted that the terms "first," "second," "symmetrical," "array," etc. are used only to distinguish descriptions from positional descriptions and should not be understood as indicating or implying relative importance or implicitly indicating the number of the technical features indicated. Therefore, limitations on features such as "first" and "symmetrical" may explicitly or implicitly include one or more of these features; similarly, when the number of certain features is not limited in the form of words such as "two" or "three," it should be noted that these features also explicitly or implicitly include one or more of the number of features.

[0033] In the present invention, unless otherwise expressly specified or limited, terms such as "installation," "connection," and "fixation" should be understood broadly; for example, they may refer to fixed connection, detachable connection, or integral molding; they may refer to mechanical connection, direct connection, welding, or indirect connection via an intermediate medium; they may refer to internal communication between two components or interaction between two components. Those skilled in the art will understand the specific meanings of these terms in the present invention based on specific circumstances.

[0034] The embodiments of the present invention are described in detail below.

[0035] The present invention discloses a formula for turning white hair into black hair based on targeted delivery of small molecules of traditional Chinese medicine. The traditional Chinese medicine formula is composed of the following raw materials: Polygonum multiflorum, black sesame, ginseng, angelica, mulberry, Eclipta prostrata, Ligustrum lucidum fruit, Platycladus orientalis leaf, liposomes, nanopolymers, amino acids, vitamins and minerals.

[0036] Specifically, the traditional Chinese medicine formula is composed of the following raw materials in parts by weight: 15-25 parts of Polygonum multiflorum, 10-20 parts of black sesame, 5-10 parts of ginseng, 8-12 parts of angelica, 12-18 parts of mulberry, 10-15 parts of Eclipta prostrata, 8-12 parts of Ligustrum lucidum fruit, 6-10 parts of Platycladus orientalis leaves, 0.5-5 parts of liposomes, 0.1-3 parts of nanopolymers, 2-6 parts of amino acids, 1-5 parts of vitamins, and 1-4 parts of minerals.

[0037] Specifically, liposomes, as drug carriers, can encapsulate small molecules of traditional Chinese medicine, improving their stability and targeting. The dosage needs to be determined based on the amount of active ingredients of the encapsulated traditional Chinese medicine and the specific targeting requirements.

[0038] Specifically, nanopolymers can precisely control drug release, and their dosage must take into account compatibility with other ingredients and their impact on drug delivery efficiency. Amino acids are important raw materials for synthesizing hair keratin, and tyrosine is also a precursor for melanin synthesis. Its dosage must meet the needs of normal hair growth and melanin synthesis.

[0039] Specifically, vitamins include B vitamins, vitamin C, and vitamin E, of which B vitamins may account for 0.5-2 parts, vitamin C accounts for 0.3-1.5 parts, and vitamin E accounts for 0.2-1 parts. Vitamins participate in the body's metabolism and play a certain role in maintaining the health of hair follicles and promoting melanin synthesis.

[0040] Specifically, minerals are involved in regulating the activity of multiple enzymes in the body and are important for maintaining the structure and function of hair.

[0041] Specifically, the formula is used to improve the problem of gray hair. Through the targeted action of small molecules of traditional Chinese medicine, it may help promote the functional recovery of hair follicle cells, regulate the synthesis and secretion of melanin, and thus achieve the transformation of gray hair into black.

[0042] Specifically, the preparation steps of the formula include:

[0043] S1. Pulverizing and extracting Chinese medicine: Pulverize Chinese medicine raw materials such as Polygonum multiflorum, black sesame, ginseng, angelica, mulberry, Ecliptae, Ligustrum lucidum, and Platycladus orientalis leaves, and pass them through a 60-100 mesh sieve for subsequent extraction. The effective ingredients of the Chinese medicine are extracted by percolation, and 60% by volume edible alcohol is used as the extraction solvent. The pulverized Chinese medicine raw materials are placed in a percolation cylinder, and soaked in an appropriate amount of solvent for 24 hours. The percolation is then slowly performed, and the percolation liquid is collected. The collected percolation liquid is concentrated using a rotary evaporator at 40-60° C. under reduced pressure to obtain a Chinese medicine extract concentrate;

[0044] S2. Nanocarrier preparation: Weigh appropriate amounts of liposomes and nanopolymers, dissolve the liposomes in chloroform, and dissolve the nanopolymers in methanol, then mix the two solutions to form a uniform mixture under magnetic stirring, and evaporate the mixture under reduced pressure on a rotary evaporator to remove the organic solvent, so that the liposomes and nanopolymers form a uniform thin film on the container wall, and add an appropriate amount of phosphate buffer to the container containing the film, and ultrasonicate at 30-40°C for 30-60 minutes to disperse the film to form a nanoscale liposome-nanopolymer complex suspension;

[0045] S3. Component mixing: Slowly add the concentrated Chinese herbal extract to the liposome-nanopolymer complex suspension while magnetically stirring at a speed of 300-500 rpm for 1-2 hours to allow the effective ingredients of the Chinese herbal medicine to be fully loaded onto the nanocarriers. Then, weighed vitamins, amino acids, and minerals are added in sequence and stirred for 30-60 minutes to allow them to be completely dissolved and mixed evenly.

[0046] S4. Lotion Forming: Adjust the volume and concentration of the mixed solution with deionized water to achieve the desired specifications of the lotion, such as a total volume of 100-500 ml, and adjust the pH value of the lotion to 5.5-7.5 with a pH regulator to adapt to the pH environment of the skin;

[0047] S5. Quality inspection and packaging: The lotion is quality inspected, including the use of high performance liquid chromatography to detect the content of effective ingredients of traditional Chinese medicine, dynamic light scattering to determine the particle size distribution of nanoparticles, and stability tests to examine the stability of the lotion under different temperature and light conditions. After passing the inspection, the lotion is filled into clean, sterile plastic bottles or glass bottles, sealed, and labeled with the product name, ingredients, instructions for use, shelf life and other information.

[0048] Specifically, the entire preparation process must be carried out in an environment that complies with Good Manufacturing Practice (GMP) for pharmaceutical production to ensure product quality and safety. At the same time, in actual production, process parameters can be optimized and adjusted according to specific circumstances.

[0049] The following are several specific embodiments of the present invention:

[0050] Example 1:

[0051] Raw material weighing and pretreatment: Accurately weigh 15 parts of Polygonum multiflorum, 20 parts of black sesame, 10 parts of ginseng, 8 parts of angelica, 10 parts of mulberry, 17 parts of Eclipta prostrata, 7 parts of Ligustrum lucidum fruit, 11 parts of Platycladus orientalis leaves, 2 parts of liposomes, 1 part of nanopolymer, 3 parts of vitamins, 4 parts of amino acids, and 2 parts of minerals to ensure that all medicinal materials are of high quality, without deterioration or impurities;

[0052] Preparation steps: a. Traditional Chinese medicine grinding and extraction: Pulverize Chinese medicinal materials such as Polygonum multiflorum, black sesame, ginseng, angelica, mulberry, Eclipta prostrata, Ligustrum lucidum fruit, and Platycladus orientalis leaves, pass through a 60-100 mesh sieve for subsequent extraction, and extract the effective ingredients of the traditional Chinese medicine by percolation. Use 60% by volume edible alcohol as the extraction solvent, place the pulverized traditional Chinese medicine raw materials in a percolation cylinder, add an appropriate amount of solvent, soak for 24 hours, slowly percolate, collect the percolation liquid, and concentrate the collected percolation liquid using a rotary evaporator at 40-60° C. under reduced pressure to obtain a concentrated traditional Chinese medicine extract;

[0053] d. Nanocarrier preparation: Weigh appropriate amounts of liposomes and nanopolymers, dissolve the liposomes in chloroform, and dissolve the nanopolymers in methanol, then mix the two solutions to form a uniform mixture under magnetic stirring. Use thin film evaporation to evaporate the mixture under reduced pressure on a rotary evaporator to remove the organic solvent, so that the liposomes and nanopolymers form a uniform thin film on the container wall. Add an appropriate amount of phosphate buffer to the container containing the film and sonicate at 30-40°C for 30-60 minutes to disperse the film to form a nanoscale liposome-nanopolymer complex suspension.

[0054] c. Component mixing: Slowly add the concentrated Chinese herbal extract to the liposome-nanopolymer complex suspension while magnetically stirring at a speed of 300-500 rpm for 1-2 hours to allow the effective components of the Chinese herbal extract to be fully loaded onto the nanocarriers. Then, weighed vitamins, amino acids, and minerals are added in sequence and stirred for 30-60 minutes to allow them to completely dissolve and mix evenly.

[0055] d. Lotion formation: The volume and concentration of the mixture are adjusted with deionized water to achieve the desired specifications, such as a total volume of 100-500 ml. The pH value of the lotion is adjusted to 5.5-7.5 with a pH regulator to adapt to the pH environment of the skin, thereby obtaining a formula for turning gray hair black based on the targeted delivery of small molecules from traditional Chinese medicine.

[0056] Example 2:

[0057] Raw material weighing and pretreatment: Accurately weigh 20 parts of Polygonum multiflorum, 10 parts of black sesame, 15 parts of ginseng, 9 parts of angelica, 9 parts of mulberry, 15 parts of Eclipta prostrata, 8 parts of Ligustrum lucidum fruit, 12 parts of Platycladus orientalis leaf, 3 parts of liposomes, 1.5 parts of nanopolymer, 2 parts of vitamins, 3.5 parts of amino acids, and 2 parts of minerals to ensure that all medicinal materials are of high quality, without deterioration or impurities;

[0058] Preparation steps: a. Traditional Chinese medicine grinding and extraction: Pulverize Chinese medicinal materials such as Polygonum multiflorum, black sesame, ginseng, angelica, mulberry, Eclipta prostrata, Ligustrum lucidum fruit, and Platycladus orientalis leaves, pass through a 60-100 mesh sieve for subsequent extraction, and extract the effective ingredients of the traditional Chinese medicine by percolation. Use 60% by volume edible alcohol as the extraction solvent, place the pulverized traditional Chinese medicine raw materials in a percolation cylinder, add an appropriate amount of solvent, soak for 24 hours, slowly percolate, collect the percolation liquid, and concentrate the collected percolation liquid using a rotary evaporator at 40-60° C. under reduced pressure to obtain a concentrated traditional Chinese medicine extract;

[0059] d. Nanocarrier preparation: Weigh appropriate amounts of liposomes and nanopolymers, dissolve the liposomes in chloroform, and dissolve the nanopolymers in methanol, then mix the two solutions to form a uniform mixture under magnetic stirring. Use thin film evaporation to evaporate the mixture under reduced pressure on a rotary evaporator to remove the organic solvent, so that the liposomes and nanopolymers form a uniform thin film on the container wall. Add an appropriate amount of phosphate buffer to the container containing the film and sonicate at 30-40°C for 30-60 minutes to disperse the film to form a nanoscale liposome-nanopolymer complex suspension.

[0060] c. Component mixing: Slowly add the concentrated Chinese herbal extract to the liposome-nanopolymer complex suspension while magnetically stirring at a speed of 300-500 rpm for 1-2 hours to allow the effective components of the Chinese herbal extract to be fully loaded onto the nanocarriers. Then, weighed vitamins, amino acids, and minerals are added in sequence and stirred for 30-60 minutes to allow them to completely dissolve and mix evenly.

[0061] d. Lotion formation: The volume and concentration of the mixture are adjusted with deionized water to achieve the desired specifications, such as a total volume of 100-500 ml. The pH value of the lotion is adjusted to 5.5-7.5 with a pH regulator to adapt to the pH environment of the skin, thereby obtaining a formula for turning gray hair black based on the targeted delivery of small molecules from traditional Chinese medicine.

[0062] Example 3:

[0063] Medicinal material selection and weighing: Carefully select 20 parts of Polygonum multiflorum, 11 parts of black sesame, 11 parts of ginseng, 13 parts of Chinese angelica, 12 parts of mulberry, 10 parts of Eclipta prostrata, 10 parts of Ligustrum lucidum fruit, 9 parts of Platycladus orientalis leaves, 3 parts of liposomes, 2 parts of nanopolymers, 2 parts of vitamins, 4 parts of amino acids, and 2 parts of minerals. Ensure that the origin and processing methods of the medicinal materials meet the requirements. Use a high-precision electronic scale during the weighing process to ensure the weight is accurate.

[0064] Preparation steps: a. Traditional Chinese medicine grinding and extraction: Pulverize Chinese medicinal materials such as Polygonum multiflorum, black sesame, ginseng, angelica, mulberry, Eclipta prostrata, Ligustrum lucidum fruit, and Platycladus orientalis leaves, pass through a 60-100 mesh sieve for subsequent extraction, and extract the effective ingredients of the traditional Chinese medicine by percolation. Use 60% by volume edible alcohol as the extraction solvent, place the pulverized traditional Chinese medicine raw materials in a percolation cylinder, add an appropriate amount of solvent, soak for 24 hours, slowly percolate, collect the percolation liquid, and concentrate the collected percolation liquid using a rotary evaporator at 40-60° C. under reduced pressure to obtain a concentrated traditional Chinese medicine extract;

[0065] d. Nanocarrier preparation: Weigh appropriate amounts of liposomes and nanopolymers, dissolve the liposomes in chloroform, and dissolve the nanopolymers in methanol, then mix the two solutions to form a uniform mixture under magnetic stirring. Use thin film evaporation to evaporate the mixture under reduced pressure on a rotary evaporator to remove the organic solvent, so that the liposomes and nanopolymers form a uniform thin film on the container wall. Add an appropriate amount of phosphate buffer to the container containing the film and sonicate at 30-40°C for 30-60 minutes to disperse the film to form a nanoscale liposome-nanopolymer complex suspension.

[0066] c. Component mixing: Slowly add the concentrated Chinese herbal extract to the liposome-nanopolymer complex suspension while magnetically stirring at a speed of 300-500 rpm for 1-2 hours to allow the effective components of the Chinese herbal extract to be fully loaded onto the nanocarriers. Then, weighed vitamins, amino acids, and minerals are added in sequence and stirred for 30-60 minutes to allow them to completely dissolve and mix evenly.

[0067] d. Lotion formation: The volume and concentration of the mixture are adjusted with deionized water to achieve the desired specifications, such as a total volume of 100-500 ml. The pH value of the lotion is adjusted to 5.5-7.5 with a pH regulator to adapt to the pH environment of the skin, thereby obtaining a formula for turning gray hair black based on the targeted delivery of small molecules from traditional Chinese medicine.

[0068] Performance tests were performed on Examples 1 to 3:

[0069] Directions for use: Gently apply this product to the scalp (apply it to the roots of gray hair externally) and massage with your fingertips, once in the morning and evening every day. After 30 days of use, the product will be tested and evaluated. Each group of cases has 20 cases, half of which are male and half are female, aged 25-55 years old.

[0070] Table 1

[0071]

[0072] The results in the table above demonstrate the efficacy of the product prepared by the present invention in the field of converting gray hair to black. Its core mechanism of action lies in its ability to effectively stimulate hair follicles, reawakening the dormant melanin production mechanism in gray hair, and accelerating the recovery of hair pigmentation. Furthermore, the product exhibits multiple synergistic effects, promoting the proliferation and differentiation of stem cells in the bulge area and providing sustained power for the healthy growth of hair follicles. Comparative studies of different embodiments revealed that the comprehensive effects of Example 3 were particularly outstanding, demonstrating significant advantages both in promoting melanin production and improving the hair follicle microenvironment.

[0073] The above description is merely a specific embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any person skilled in the art can easily conceive of various modifications and substitutions within the technical scope disclosed in the present invention, and such modifications and substitutions are intended to be within the scope of protection of the present invention. Therefore, the scope of protection of the present invention shall be subject to the scope of protection of the claims.

Claims

1. A formula for turning white hair black based on targeted delivery of small molecules from traditional Chinese medicine, characterized in that: The traditional Chinese medicine formula is composed of the following raw materials: Polygonum multiflorum, black sesame, ginseng, angelica, mulberry, Eclipta prostrata, Ligustrum lucidum fruit, Platycladus orientalis leaf, liposome, nanopolymer, amino acid, vitamins and minerals.

2. A formula for turning white hair black based on targeted delivery of small molecules of traditional Chinese medicine according to claim 1, characterized in that: The traditional Chinese medicine formula is composed of the following raw materials in parts by weight: 15-25 parts of Polygonum multiflorum, 10-20 parts of black sesame, 5-10 parts of ginseng, 8-12 parts of angelica, 12-18 parts of mulberry, 10-15 parts of Eclipta prostrata, 8-12 parts of Ligustrum lucidum fruit, 6-10 parts of Platycladus orientalis leaves, 0.5-5 parts of liposomes, 0.1-3 parts of nanopolymers, 2-6 parts of amino acids, 1-5 parts of vitamins, and 1-4 parts of minerals.

3. The formula for turning white hair black based on targeted delivery of small molecules of traditional Chinese medicine according to claim 1, characterized in that: The liposomes, as drug carriers, can encapsulate small molecules of traditional Chinese medicine and improve their stability and targeting. The dosage needs to be determined according to the amount of active ingredients of the encapsulated traditional Chinese medicine and the specific targeting requirements.

4. The formula for turning white hair black based on targeted delivery of small molecules of traditional Chinese medicine according to claim 1, characterized in that: The nanopolymer can precisely control drug release, and its dosage must take into account compatibility with other ingredients and its impact on drug delivery efficiency. The amino acid is an important raw material for synthesizing hair keratin, and tyrosine is also a precursor for melanin synthesis. Its dosage must meet the needs of normal hair growth and melanin synthesis.

5. The formula for turning white hair into black hair based on targeted delivery of small molecules of traditional Chinese medicine according to claim 1, characterized in that: The vitamins include B vitamins, vitamin C, and vitamin E, among which B vitamins may account for 0.5-2 parts, vitamin C accounts for 0.3-1.5 parts, and vitamin E accounts for 0.2-1 parts. Vitamins participate in the body's metabolism and play a certain role in maintaining hair follicle health and promoting melanin synthesis.

6. The formula for turning white hair black based on targeted delivery of small molecules of traditional Chinese medicine according to claim 1, characterized in that: Among them, minerals participate in the regulation of the activity of multiple enzymes in the body and are of great significance to the maintenance of hair structure and function.

7. The formula for turning white hair black based on targeted delivery of small molecules of traditional Chinese medicine according to claim 1, characterized in that: The formula is used to improve the problem of gray hair. Through the targeted effect of small molecules of traditional Chinese medicine, it may help promote the functional recovery of hair follicle cells, regulate the synthesis and secretion of melanin, and thus achieve the transformation of gray hair into black.

8. The formula for turning white hair into black hair based on targeted delivery of small molecules of traditional Chinese medicine according to claim 1, characterized in that: The steps for preparing the formula include: S1. Pulverizing and extracting Chinese medicine: Pulverize Chinese medicine raw materials such as Polygonum multiflorum, black sesame, ginseng, angelica, mulberry, Ecliptae, Ligustrum lucidum, and Platycladus orientalis leaves, and pass them through a 60-100 mesh sieve for subsequent extraction. The effective ingredients of the Chinese medicine are extracted by percolation, and 60% by volume edible alcohol is used as the extraction solvent. The pulverized Chinese medicine raw materials are placed in a percolation cylinder, and soaked in an appropriate amount of solvent for 24 hours. The percolation is then slowly performed, and the percolation liquid is collected. The collected percolation liquid is concentrated using a rotary evaporator at 40-60° C. under reduced pressure to obtain a Chinese medicine extract concentrate; S2. Nanocarrier preparation: Weigh appropriate amounts of liposomes and nanopolymers, dissolve the liposomes in chloroform, and dissolve the nanopolymers in methanol, then mix the two solutions to form a uniform mixture under magnetic stirring, and evaporate the mixture under reduced pressure on a rotary evaporator to remove the organic solvent, so that the liposomes and nanopolymers form a uniform thin film on the container wall, and add an appropriate amount of phosphate buffer to the container containing the film, and ultrasonicate at 30-40°C for 30-60 minutes to disperse the film to form a nanoscale liposome-nanopolymer complex suspension; S3. Component mixing: Slowly add the concentrated Chinese herbal extract to the liposome-nanopolymer complex suspension while magnetically stirring at a speed of 300-500 rpm for 1-2 hours to allow the effective ingredients of the Chinese herbal medicine to be fully loaded onto the nanocarriers. Then, weighed vitamins, amino acids, and minerals are added in sequence and stirred for 30-60 minutes to allow them to be completely dissolved and mixed evenly. S4. Lotion Forming: Adjust the volume and concentration of the mixed solution with deionized water to achieve the desired specifications of the lotion, such as a total volume of 100-500 ml, and adjust the pH value of the lotion to 5.5-7.5 with a pH regulator to adapt to the pH environment of the skin; S5. Quality inspection and packaging: The lotion is quality inspected, including the use of high performance liquid chromatography to detect the content of effective ingredients of traditional Chinese medicine, dynamic light scattering to determine the particle size distribution of nanoparticles, and stability tests to examine the stability of the lotion under different temperature and light conditions. After passing the inspection, the lotion is filled into clean, sterile plastic bottles or glass bottles, sealed, and labeled with the product name, ingredients, instructions for use, shelf life and other information.

9. The formula for turning white hair black based on targeted delivery of small molecules of traditional Chinese medicine according to claim 8, characterized in that: The entire preparation process must be carried out in an environment that complies with Good Manufacturing Practice (GMP) to ensure product quality and safety. At the same time, in actual production, process parameters can be optimized and adjusted according to specific circumstances.

Images