Traditional Chinese medicine composition and application thereof in preparation of medicine for improving yin deficiency constitution
By preparing a variety of dosage forms of a traditional Chinese medicine composition consisting of lily, mulberry, momordica grosvenori, etc., combined with bitter almonds and black plums, the problem of improving Yin deficiency constitution is solved, and related symptoms are significantly improved and the risk of disease is reduced.
Patent Information
- Application Number
- CN202510922750.2
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-07-04
- Publication Date
- 2025-09-16
AI Technical Summary
The existing technology lacks effective traditional Chinese medicine compositions to improve Yin deficiency constitution, which leads to the occurrence and development of related symptoms and diseases, especially a higher risk of hypertension, osteoporosis and diabetes.
Provided is a traditional Chinese medicine composition, which is composed of lily, mulberry, momordica grosvenori, mulberry leaf, puffed tamarind, polygonatum, hemp seed and roasted licorice, and is further added with bitter almond and black plum. The composition is prepared by preparing an extract or extracts into ointments, capsules, granules, tablets, concentrated pills and the like for use in improving yin deficiency constitution.
Significantly improve Yin deficiency constitution by regulating cyclic nucleotide metabolism, reducing T3 levels, increasing the cAMP/cGMP ratio, improving related symptoms such as dry nose, dry throat, dry mouth, hot palms and soles, etc., and reducing the risk of hypertension and diabetes.
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Figure CN120643641A_ABST
Abstract
Description
Technical Field
[0001] The present invention relates to the technical field of traditional Chinese medicines, and in particular to a traditional Chinese medicine composition and application thereof in preparing a medicine for improving yin deficiency constitution. Background Art
[0002] Yin deficiency is a physical condition characterized by a deficiency of Yin fluids, such as body fluids, essence, and blood. Symptoms of this condition include a dry nose, dry throat, and mouth, thirst, a preference for cold drinks, a red tongue with scant coating, warm palms and soles, and dry stools, all associated with internal heat. Studies have found that people with Yin deficiency have a 3.086-fold, 3.167-fold, and 1.859-fold higher risk of hypertension, osteoporosis, and diabetes, respectively, than those without Yin deficiency. Traditional Chinese Medicine (TCM) believes that Yin deficiency leads to uneven distribution of Yin fluids, preventing the internal organs and meridians from receiving these fluids, which in turn generates internal dryness and heat, leading to the thirst associated with diabetes. This deficiency in essence, blood, and body fluids results in Yin deficiency, which in turn prevents the control of Yang, resulting in an overabundance of Yang Qi, which then rises and manifests as dizziness associated with hypertension. Yin deficiency is more common in certain demographics, particularly those older than middle age. Furthermore, individuals with sub-health conditions also have a relatively high prevalence of Yin deficiency. An epidemiological survey of Traditional Chinese Medicine (TCM) constitutions revealed that Yin deficiency is the most common constitution among people over 65. Symptoms of Yin deficiency, such as dry mouth and nose, dry stools, frequent thirst, and warm palms and soles, affect a person's quality of life and well-being. Yin deficiency is also associated with the development and progression of various diseases, including hypertension, constipation, diabetes, and cerebrovascular disease. Without intervention, these conditions can lead to the development of these diseases over time.
[0003] Currently, treatments for Yin deficiency primarily include lifestyle and dietary adjustments and Traditional Chinese Medicine (TCM). The book "Chinese Constitutional Theory" states that dietary adjustments for those with Yin deficiency can address three key aspects: emotions, diet, and daily life. First, regarding emotions, individuals with Yin deficiency are often irritable, active, and easily angered. Therefore, individuals with Yin deficiency should maintain a stable and peaceful state of mind and learn to properly manage their emotions. Second, regarding diet, individuals with Yin deficiency, due to a lack of Yin fluid in their bodies, should consume more Yin-nourishing foods, such as duck and pork, and avoid spicy foods. Finally, regarding daily life, individuals with Yin deficiency should ensure adequate sleep and increase physical exercise to nourish Yin Qi and maintain a balanced Yin-Yang state.
[0004] Traditional Chinese Medicine (TCM) theory holds that a yin deficiency constitution is caused by a deficiency of yin fluid in the human body, and its treatment primarily focuses on nourishing yin and replenishing essence. Therefore, it is of great significance to provide a Chinese medicine composition that can intervene in patients with yin deficiency, thereby improving symptoms and the progression of related diseases. Summary of the Invention
[0005] In order to overcome at least one technical problem existing in the prior art, the present invention provides a traditional Chinese medicine composition and its use in preparing a medicine for improving Yin deficiency constitution.
[0006] The above technical problems to be solved by the present invention are achieved through the following technical solutions:
[0007] The present invention first provides a traditional Chinese medicine composition, which comprises the following traditional Chinese medicine raw material components: lily, mulberry, momordica grosvenori, mulberry leaf, pterostilbene, polygonatum, hemp seed and roasted liquorice.
[0008] The inventors believe that lily is sweet, slightly cold, and has a mild effect. It can replenish lung yin, clear lung heat, and relieve cough. For chronic cough caused by lung deficiency, "Lily Solidifying Gold Decoction" (Shen Zhai Yishu) is used, so this prescription uses lily as the main medicine. Mulberry nourishes yin and blood, promotes fluid and moistens dryness, replenishes liver and kidney yin, and can also moisten the intestines and promote bowel movements; Momordica grosvenori and Sterculia lychnophora can both clear the lungs and relieve sore throats, and moisten the intestines and promote bowel movements; mulberry leaves are sweet, cold, and moisturizing, clearing lung dryness, such as Sangxing Decoction (Treatise on Warm Diseases); Polygonatum nourishes yin and moistens dryness, and can also clear lung heat; Hemp seed can moisten the intestines and promote bowel movements, descend and promote lung qi, and can relieve cough and asthma; and roasted licorice root implies "sour and sweet transforming yin", nourishing yin and promoting fluid. In summary, the composition of the present invention can improve yin deficiency constitution.
[0009] Preferably, the Chinese medicine composition comprises the following Chinese medicine raw material components in parts by weight:
[0010] 5-60 parts of lilies, 5-40 parts of mulberries, 5-30 parts of momordica grosvenori, 5-20 parts of mulberry leaves, 5-30 parts of sterculia lychnophora, 5-30 parts of polygonatum, 10-30 parts of hemp seeds, and 5-20 parts of roasted liquorice.
[0011] Further preferably, the Chinese medicine composition comprises the following Chinese medicine raw material components in parts by weight:
[0012] 10-40 parts of lilies, 10-30 parts of mulberries, 5-20 parts of momordica grosvenori, 5-20 parts of mulberry leaves, 5-20 parts of puffed seaweed, 5-20 parts of polygonatum, 10-30 parts of hemp seeds, and 5-20 parts of roasted liquorice.
[0013] Preferably, the composition further comprises bitter almonds and black plums.
[0014] In further research, the inventors found that further adding bitter almonds and black plums to the traditional Chinese medicine composition containing lily, mulberry, momordica grosvenori, mulberry leaves, sterculia lychnophora, polygonatum, hemp seed and licorice can significantly enhance the effect of the traditional Chinese medicine composition of the present invention in improving yin deficiency constitution.
[0015] More preferably, the weight proportions of bitter almonds and black plums in the composition are: 5 to 30 parts of bitter almonds and 5 to 20 parts of black plums.
[0016] Most preferably, the Chinese medicine composition comprises the following Chinese medicine raw material components in parts by weight:
[0017] 30 parts of lily bulbs, 25 parts of mulberries, 15 parts of momordica grosvenori, 10 parts of mulberry leaves, 15 parts of pistachios, 15 parts of polygonatum, 20 parts of hemp seeds, 15 parts of bitter almonds, 10 parts of black plums, and 10 parts of roasted liquorice; or
[0018] 20 parts of lily bulbs, 15 parts of mulberries, 10 parts of momordica grosvenori, 5 parts of mulberry leaves, 10 parts of pistachios, 10 parts of polygonatum, 15 parts of hemp seeds, 10 parts of bitter almonds, 5 parts of black plums, and 5 parts of roasted liquorice; or
[0019] 25 parts of lilies, 20 parts of mulberries, 15 parts of momordica grosvenori, 10 parts of mulberry leaves, 15 parts of sterculia lychnophora, 15 parts of polygonatum, 20 parts of hemp seeds, 15 parts of bitter almonds, 20 parts of black plums, and 20 parts of preheated liquorice.
[0020] The present invention also provides an application of the above-mentioned traditional Chinese medicine composition in preparing a medicine for improving Yin deficiency constitution.
[0021] Preferably, the medicine uses the extract or extract prepared from the Chinese medicine composition of the present invention as a raw material as an active ingredient.
[0022] Preferably, the extract is prepared by the following method:
[0023] Extracting the above-mentioned Chinese medicine composition of the present invention with a solvent to obtain an extract;
[0024] The extract is prepared by the following method:
[0025] The Chinese medicine composition of the present invention is extracted with a solvent to obtain an extract; the extract is concentrated and dried to obtain the extract.
[0026] Preferably, the solvent is water or ethanol.
[0027] Preferably, the pharmaceutical dosage form is an ointment.
[0028] Beneficial effects: The present invention provides a new Chinese medicine composition; studies have shown that the Chinese medicine composition has the effect of improving Yin deficiency constitution; therefore, the Chinese medicine composition of the present invention can be used as a medicine for improving Yin deficiency constitution, and has important application value. BRIEF DESCRIPTION OF THE DRAWINGS
[0029] Figure 1 The graphs show the T3 and T4 results of rats in each group.
[0030] Figure 2 The graphs show the results of cAMP, cGMP, and cAMP / cGMP in rats of each group. DETAILED DESCRIPTION
[0031] The present invention is further explained below with reference to specific examples, but the examples do not limit the present invention in any form.
[0032] Example 1 Chinese medicine composition
[0033] The components of the Chinese medicine composition are as follows: 30 parts of lily, 25 parts of mulberry, 15 parts of momordica grosvenori, 10 parts of mulberry leaf, 15 parts of pistachio, 15 parts of polygonatum, 20 parts of hemp seed, and 10 parts of roasted liquorice root;
[0034] Example 2 Chinese medicine composition
[0035] The weight proportions of the components in the Chinese medicine composition are as follows:
[0036] 30 parts of lily bulbs, 25 parts of mulberries, 15 parts of momordica grosvenori, 10 parts of mulberry leaves, 15 parts of sterculia lychnophora, 15 parts of polygonatum, 20 parts of hemp seeds, 15 parts of bitter almonds, 10 parts of black plums, and 10 parts of roasted liquorice root;
[0037] Example 3 Chinese medicine composition
[0038] The components of the traditional Chinese medicine composition are composed of 20 parts by weight of lily, 15 parts of mulberry, 10 parts of momordica grosvenori, 5 parts of mulberry leaf, 10 parts of pistachio, 10 parts of polygonatum, 15 parts of hemp seed, 10 parts of bitter almond, 5 parts of black plum and 5 parts of roasted liquorice.
[0039] Example 4 Chinese medicine composition
[0040] The components of the traditional Chinese medicine composition are composed of 25 parts of lily, 20 parts of mulberry, 15 parts of momordica grosvenori, 10 parts of mulberry leaf, 15 parts of pistachio, 15 parts of polygonatum, 20 parts of hemp seed, 15 parts of bitter almond, 20 parts of black plum and 20 parts of roasted liquorice.
[0041] Example 5 Chinese medicine composition
[0042] The components of the traditional Chinese medicine composition are composed of 40 parts by weight of lily, 30 parts of mulberry, 30 parts of momordica grosvenori, 10 parts of mulberry leaf, 10 parts of pistachio, 5 parts of polygonatum, 5 parts of hemp seed, 5 parts of bitter almond, 10 parts of black plum and 10 parts of roasted liquorice.
[0043] Example 6 Chinese medicine composition
[0044] The components of the traditional Chinese medicine composition are composed of 15 parts of lily, 10 parts of mulberry, 10 parts of momordica grosvenori, 10 parts of mulberry leaf, 15 parts of pistachio, 10 parts of polygonatum, 15 parts of hemp seed, 30 parts of bitter almond, 10 parts of black plum and 10 parts of roasted liquorice.
[0045] Experimental Example 1
[0046] Take the Chinese medicine compositions described in Examples 1 and 2, add 10 times the total weight of water to each of the Chinese medicine compositions, and perform reflux extraction at 100° C. for 1 hour. After the extraction, the extracts are concentrated and dried to obtain extracts 1 and 2, which are used for subsequent tests.
[0047] (1) Experimental methods
[0048] Sixteen rats were adaptively reared and divided into four groups: a normal control group, a model group, experimental group 1, and experimental group 2, with four rats in each group. Rats in the model group, experimental group 1, and experimental group 2 received an intramuscular injection of 0.35 mg / kg of dexamethasone sodium phosphate, while the normal control group received an equal volume of normal saline for 20 consecutive days. On the 10th day, rats in experimental group 1 were gavaged with Extract 1, and rats in experimental group 2 were gavaged with Extract 2, at a daily dose of 1.26 mg / g for 11 days. On the 21st day, the rats were anesthetized, and blood was collected through the abdominal aorta and centrifuged for analysis of indicators such as cAMP, cGMP, cAMP / cGMP, and T3. Combining Traditional Chinese Medicine descriptions with modern research, Yin deficiency is a pathological condition characterized by a predominance of sympathetic nervous system excitation, endocrine hyperactivity disorder, enhanced metabolism, relatively increased heat production, and impaired cyclic nucleotide metabolism. By detecting the indicators of cAMP, cGMP value, cAMP / cGMP value and T3, the improvement effect of traditional Chinese medicine on Yin deficiency state can be reflected.
[0049] (2) Experimental results
[0050] 1.T3.
[0051] Figure 1 The experimental results showed that the T3 of the model group was significantly higher than that of the blank group (p<0.0001), indicating that the modeling was successful. The T3 of the two experimental groups 1 and 2 was lower than that of the model group, indicating that the Chinese medicine composition of the present invention can improve the yin deficiency state of rats (p<0.005).
[0052] In addition, from Figure 1 The results also showed that the T3 of experimental group 2 was significantly lower than that of experimental group 1 (p < 0.05). This indicates that the addition of bitter almonds and black plums to the traditional Chinese medicine composition containing lily, mulberry, monk fruit, mulberry leaf, pistachio, polygonatum, hemp seed, and licorice root can significantly enhance the effect of the traditional Chinese medicine composition of the present invention in improving yin deficiency.
[0053] 2.cAMP, cGMP, cAMP / cGMP.
[0054] Figure 2The experimental results showed that the cAMP and cGMP of the model group were significantly different from those of the blank group (p < 0.0001). Among them, the cAMP of the model group was significantly increased compared with the blank group, and the cGMP of the model group was significantly decreased compared with the blank group, which was consistent with the clinical manifestations of Yin deficiency and indicated that the model was successful. After medication, the cAMP in experimental groups 1 and 2 was significantly decreased (p < 0.0001), and the cAMP / cGMP ratio approached the normal level (p < 0.005). The cGMP in experimental groups 1 and 2 was significantly increased (p < 0.0001), confirming that the traditional Chinese medicine composition of the present invention has the effect of regulating cyclic nucleotide metabolism, indicating that the traditional Chinese medicine composition of the present invention can improve the Yin deficiency state of rats.
[0055] In addition, the cAMP / cGMP ratio of experimental group 2 was closer to the normal level than that of experimental group 1. This indicates that the addition of bitter almonds and black plums to the traditional Chinese medicine composition comprising lily, mulberry, momordica grosvenori, mulberry leaf, pteridophytum corylifolia, polygonatum, hemp seed, and licorice root can significantly enhance the effect of the traditional Chinese medicine composition of the present invention in improving yin deficiency.
[0056] Example 7 Preparation of Decoction
[0057] Take the components of the Chinese medicine composition in Example 1, add 10 times the total weight of water of the Chinese medicine composition, first decoct with high heat for 20 minutes, and then decoct with low heat for 40 minutes; after decoction is completed, filter the residue and take the decoction to obtain a decoction.
[0058] Example 8 Preparation of Capsules
[0059] Take the components in the Chinese medicine composition of Example 2, add 8 times the total weight of water of the Chinese medicine composition, and perform heating reflux extraction for 1.5 hours. After extraction, filter the residue to obtain an extract, and concentrate and dry the extract to obtain an extract.
[0060] The extract is further used as an effective ingredient to prepare capsules using conventional methods in the art.
[0061] Example 9 Preparation of Capsules
[0062] Take the components of the Chinese medicine composition in Example 3, add 8 times the total weight of water of the Chinese medicine composition, and perform heating reflux extraction for 1.5 hours. After extraction, filter the residue to obtain an extract, and concentrate and dry the extract to obtain an extract;
[0063] The extract is further used as an effective ingredient to prepare capsules using conventional methods in the art.
[0064] Example 10 Preparation of capsules
[0065] Take the components of the Chinese medicine composition in Example 4, add 15 times the total weight of water of the Chinese medicine composition, and perform heating reflux extraction for 1 hour. After extraction, filter the residue to obtain an extract, and concentrate and dry the extract to obtain an extract;
[0066] The extract is further used as an effective ingredient to prepare capsules using conventional methods in the art.
[0067] Example 11 Preparation of granules
[0068] Take the components of the Chinese medicine composition in Example 6, add 50% ethanol aqueous solution with a volume fraction of 5 times the total weight of the Chinese medicine composition, and perform heating reflux extraction for 1 hour. After extraction, filter the medicinal residue to obtain an extract, and concentrate and dry the extract to obtain an extract;
[0069] The extract is further used as an effective ingredient to prepare granules using conventional methods in the art.
[0070] Example 12 Preparation of ointment
[0071] Take the components of the Chinese medicine composition in Example 1, add 75% ethanol aqueous solution with a volume fraction of 8 times the total weight of the Chinese medicine composition, and perform heating reflux extraction for 1 hour. After extraction, filter the medicinal residue to obtain an extract, and concentrate and dry the extract to obtain an extract;
[0072] The extract is further used as an effective ingredient to prepare an ointment using a conventional method in the art.
[0073] Example 13 Preparation of Tablets
[0074] Take the components of the Chinese medicine composition in Example 2, add 15% ethanol aqueous solution with a volume fraction of 10 times the total weight of the Chinese medicine composition, and perform heating reflux extraction for 1.5 hours. After extraction, filter the medicinal residue to obtain an extract, and concentrate and dry the extract to obtain an extract;
[0075] The extract is further used as an active ingredient to prepare tablets using conventional methods in the art.
[0076] Example 14 Preparation of Concentrated Pills
[0077] Take the components of the Chinese medicine composition in Example 2, add 10 times the weight of water of the total weight of the Chinese medicine composition, and perform heating reflux extraction for 2 hours. After extraction, filter the residue to obtain an extract, and concentrate and dry the extract to obtain an extract;
[0078] The extract is further used as an effective ingredient to prepare concentrated pills using conventional methods in the art.
Claims
1. A Chinese medicine composition, characterized in that It contains the following Chinese medicinal raw materials: lily, mulberry, momordica grosvenori, mulberry leaf, sterculia lychnophora, polygonatum, hemp seed and roasted licorice.
2. The Chinese medicine composition according to claim 1, characterized in that Contains the following Chinese medicine raw material components in parts by weight: 5-60 parts of lilies, 5-40 parts of mulberries, 5-30 parts of momordica grosvenori, 5-20 parts of mulberry leaves, 5-30 parts of sterculia lychnophora, 5-30 parts of polygonatum, 10-30 parts of hemp seeds, and 5-20 parts of roasted liquorice.
3. The Chinese medicine composition according to claim 1, characterized in that Contains the following Chinese medicine raw material components in parts by weight: 10-40 parts of lilies, 10-30 parts of mulberries, 5-20 parts of momordica grosvenori, 5-20 parts of mulberry leaves, 5-20 parts of puffed seaweed, 5-20 parts of polygonatum, 10-30 parts of hemp seeds, and 5-20 parts of roasted liquorice.
4. The Chinese medicine composition according to claim 1, characterized in that The composition also contains bitter almonds and black plums.
5. The Chinese medicine composition according to claim 1, characterized in that The weight proportions of bitter almonds and black plums in the composition are: 5 to 30 parts of bitter almonds and 5 to 20 parts of black plums.
6. The Chinese medicine composition according to claim 5, characterized in that Contains the following Chinese medicine raw material components in parts by weight: 30 parts of lily bulbs, 25 parts of mulberries, 15 parts of momordica grosvenori, 10 parts of mulberry leaves, 15 parts of sterculia lychnophora, 15 parts of polygonatum, 20 parts of hemp seeds, 15 parts of bitter almonds, 10 parts of black plums, and 10 parts of roasted liquorice root; or, 20 parts of lily bulbs, 15 parts of mulberries, 10 parts of momordica grosvenori, 5 parts of mulberry leaves, 10 parts of pistachios, 10 parts of polygonatum, 15 parts of hemp seeds, 10 parts of bitter almonds, 5 parts of black plums, and 5 parts of roasted liquorice; or 25 parts of lilies, 20 parts of mulberries, 15 parts of momordica grosvenori, 10 parts of mulberry leaves, 15 parts of sterculia lychnophora, 15 parts of polygonatum, 20 parts of hemp seeds, 15 parts of bitter almonds, 20 parts of black plums, and 20 parts of preheated liquorice.
7. Use of the traditional Chinese medicine composition according to any one of claims 1 to 6 in the preparation of a medicine for improving Yin deficiency constitution.
8. The use according to claim 7, characterized in that The medicine uses the extract or extract prepared from the Chinese medicine composition according to any one of claims 1 to 6 as a raw material as an active ingredient.
9. The use according to claim 8, characterized in that: The extract is prepared by the following method: Extracting the traditional Chinese medicine composition according to any one of claims 1 to 6 with a solvent to obtain an extract; The extract is prepared by the following method: The Chinese medicine composition according to any one of claims 1 to 6 is extracted with a solvent to obtain an extract; and the extract is concentrated and dried to obtain the extract.
10. The use according to claim 9, characterized in that The solvent is water or ethanol.