Biological sample storage device and management system thereof

Abstract

The application relates to the technical field of biological sample storage, in particular to a biological sample storage device and a management system thereof, which can solve the problems of limited storage density, insufficient sample security guarantee and lack of intelligent management of the existing biological sample storage device. The biological sample storage device comprises a multi-hole net plate type structure storage area, a plate frame storage area, a fan-shaped disc storage area and a blood bag box storage area and corresponding management systems. The multi-hole net plate type structure storage area comprises different specification test tube storage areas which are arranged by high-density aluminum tubes. The inner wall of the aluminum tube is plated with a polytetrafluoroethylene coating. The top is provided with a test tube plate frame storage area. The fan-shaped disc storage area is located at the lower part of the multi-hole net plate type structure and is composed of multiple material discs. The fan-shaped disc storage area can store cryogenic tubes alone or in mixture. The blood bag box storage area is uniformly distributed around the fan-shaped disc and can store different specification blood bag boxes. The management system is used for monitoring and managing sample information, environmental parameters and operation records in the storage device.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of biological sample storage, in particular to a biological sample storage device and a management system thereof. BACKGROUND

[0002] The early biological sample preservation method mainly relies on low-temperature refrigerators, liquid nitrogen tanks and other equipment. Although these devices can provide a certain low-temperature environment, the storage conditions are limited, and it is difficult to fully guarantee the activity and safety of the samples. With the rapid development of precision medicine, genomics, translational medicine, information big data and artificial intelligence, the demand for biological sample resources is also increasing. Biological samples are non-renewable resources, which are the basis for exploring the occurrence, diagnosis and distribution of diseases, and are also an important guarantee for disease prevention, intervention, control, diagnosis and treatment, and drug research and development.

[0003] The traditional storage system relying on manual racks and cryogenic boxes has limited storage density due to structural gaps and insufficient vertical space utilization, which is difficult to meet the current requirements for efficient storage of biological samples. At the same time, most of the existing biological sample storage devices lack intelligent management systems, and cannot monitor sample information and storage environment parameters in real time, making it difficult to effectively manage and trace the sample storage process.

[0004] Therefore, there is an urgent need for a biological sample storage device and a management system thereof that can improve space utilization, ensure sample safety and stability, and have intelligent management functions. SUMMARY

[0005] In order to solve the problems of limited storage density, insufficient sample safety guarantee and lack of intelligent management of existing biological sample storage devices, the present application provides a biological sample storage device and a management system thereof.

[0006] Embodiments of the present application are implemented as follows:

[0007] In a first aspect, the present application provides a biological sample storage device, comprising a multi-hole net plate structure storage area, a plate rack storage area, a fan-shaped disc storage area and a blood bag box storage area;

[0008] The multi-hole net plate structure storage area comprises a 2ml test tube storage area and a 0.5ml test tube storage area, which are arranged in a high-density aluminum tube closed by different sizes, wherein the gap between the 2ml test tube storage high-density aluminum tube stores the 0.5ml test tube storage high-density aluminum tube, and the inner wall of the high-density aluminum tube is coated with a polytetrafluoroethylene coating;

[0009] The top of the multi-hole net plate structure is provided with a 2ml 48-hole test tube plate rack, a 0.5ml 96-hole test tube plate rack and a 10x10 standard test tube plate rack storage area;

[0010] The fan-shaped disc storage area is located below the multi-hole mesh plate structure, and the disc can be composed of different materials such as copper, aluminum or ABS. Each disc can store 0.5ml or 2.0ml cryogenic tubes as a whole, or mix 0.5ml or 2.0ml cryogenic tubes;

[0011] The blood bag box storage area is uniformly distributed around the fan-shaped disc, used for storing 25ml blood bag boxes, 50ml blood bag boxes and 250ml blood bag boxes; the management system is used for monitoring and managing sample information, environmental parameters and operation records in the storage device.

[0012] In a possible implementation, the high-density aluminum tubes of the multi-hole mesh plate structure storage area are arranged in a regular and dense array, and the arrangement density is not less than 10 storage sites per square decimeter, so as to maximize the use of storage space.

[0013] In a possible implementation, the outer wall of the high-density aluminum tube is provided with a reinforcing rib structure, and the cross-sectional shape of the reinforcing rib is triangular, and the height is 1 / 5 to 1 / 4 of the outer diameter of the aluminum tube, so as to enhance the structural strength of the aluminum tube and prevent deformation.

[0014] In a possible implementation, the shape of the fan-shaped disc is a sector with a central angle of 45° to 90°, and the thickness is 3mm to 5mm. The surface is provided with anti-slip texture, and the texture depth is 0.1mm to 0.2mm, so as to improve the stability and operation safety of the disc.

[0015] In a possible implementation, the blood bag box storage area is provided with an elastic fixing device inside each storage site, and the elastic fixing device is made of silicone rubber material, and the elastic coefficient is 0.1MPa to 0.3MPa, which can adapt to the size of different specifications of blood bag boxes, and ensure the stability of the blood bag box during storage.

[0016] In a possible implementation, the shelf of the shelf storage area is made of aluminum alloy material, and the surface is subjected to anodic oxidation treatment, and the thickness of the oxidation film is 10μm to 15μm, which has good wear resistance and corrosion resistance. A plurality of ventilation holes are arranged on the shelf, and the diameter of the ventilation hole is 3mm to 5mm, and the hole spacing is 8mm to 10mm, so as to promote the gas exchange of the storage environment.

[0017] In a second aspect, the application provides a biological sample storage device management system, comprising a sample information management module, an environmental parameter monitoring module, an operation record module and an alarm module.

[0018] The sample information management module is used for storing and querying basic information, storage location and state information of the sample;

[0019] The environmental parameter monitoring module is used for monitoring temperature, humidity and gas composition in the storage device in real time and transmitting data to a monitoring terminal;

[0020] The operation record module is used for recording time, operating personnel and operation content of opening, closing, sample access and the like of the storage device;

[0021] The alarm module sends an audible and light alarm signal when the environmental parameter exceeds a preset range or an abnormal situation occurs, and sends alarm information to a preset mobile terminal.

[0022] In a possible implementation, the system further comprises a user permission management module, which adopts a multi-level permission management mechanism to divide users into three levels of administrator, operator and visitor, and different levels of users have different operation permissions and data access permissions, and the administrator can perform system setting and user management operations;

[0023] The operator can perform sample access, daily maintenance and the like;

[0024] The visitor can only perform limited information query, so as to ensure safety of the system and confidentiality of data.

[0025] In a possible implementation, the environmental parameter monitoring module comprises a plurality of temperature sensors, humidity sensors and gas sensors;

[0026] The temperature sensor is made of high-precision thermal resistance material, has a measurement accuracy of ±0.1℃ and a response time of 1s to 2s;

[0027] The humidity sensor is based on a capacitive measurement principle, has a measurement accuracy of ±2%RH and a response time of 3s to 5s;

[0028] The gas sensor is used for detecting gas concentrations such as oxygen and carbon dioxide, has a measurement accuracy of ±0.5% and a response time of 5s to 8s, and each sensor is uniformly distributed in the storage device, so as to ensure accuracy and representativeness of monitoring data.

[0029] In a possible implementation, the storage device as a whole adopts a double-layer structure design, the outer layer is a heat preservation layer, the heat preservation layer material is polyurethane foam, the thickness is 50mm to 80mm, and the heat preservation layer has good heat insulation performance, the inner layer is a storage layer, the storage layer is internally provided with a plurality of partitions, the partitions are detachable, and the layout of the storage area can be flexibly adjusted according to different sample storage requirements, and the storage device is provided with a mobile base at the bottom, the base is installed with four universal wheels, the universal wheels have a self-locking function, and the storage device is convenient to move and fix.

[0030] The technical scheme provided by the application can achieve at least the following beneficial effects:

[0031] The application realizes mixed storage of different specifications of test tubes through the innovative design of the porous mesh plate structure, solves the technical problem of mixed storage of different specifications of test tubes by adopting physical isolation, improves the storage efficiency and space utilization, is compatible with whole plate biological sample storage and blood box (bag) storage, the storage areas cooperate with each other to form an integrated storage system, independent operation control can be realized, and the operation is flexible and convenient, thereby meeting the storage requirements of different biological samples.

[0032] The application adopts high-density aluminum pipes as the test tube storage structure, the inner wall is coated with a polytetrafluoroethylene coating, the lubricity is increased, the risk of test tube jamming is reduced, the safety and reliability of sample storage are improved, the fan-shaped disc storage area can select discs made of different materials according to actual requirements, the storage of different specifications and types of cryopreservation tubes is adapted, the versatility and flexibility of the storage device are further improved, the uniform distribution of the blood bag box storage area reasonably utilizes the space of the storage device, improves the storage density, and facilitates the storage and retrieval of the blood bag box, the plate frame of the plate frame storage area is made of aluminum alloy material and is subjected to anodic oxidation treatment on the surface, has good wear resistance and corrosion resistance, and the air holes on the plate frame promote the gas exchange of the storage environment and are beneficial to the preservation of samples.

[0033] The application realizes comprehensive monitoring and management of sample information, environmental parameters and operation records in the storage device through the management system, improves the management level and safety of sample storage through intelligent means, facilitates the management personnel to query, count and trace the samples, the alarm function of the management system can timely alarm and notify the relevant personnel when the environmental parameters are abnormal, effectively guarantees the safety of the samples, reduces the risk of sample loss caused by environmental changes, the user permission management module ensures the safety of the system and the confidentiality of the data, prevents unauthorized access and operation, and guarantees the safety of the sample information.

[0034] The storage device of the application adopts a double-layer structure design as a whole, the outer thermal insulation layer adopts polyurethane foam material and has good heat insulation performance, the detachable partition plate design of the inner storage layer can flexibly adjust the layout according to different sample storage requirements, the mobile base at the bottom is provided with self-locking universal wheels, which facilitates the movement and fixation of the storage device, and improves the practicability and convenience of the device. BRIEF DESCRIPTION OF DRAWINGS

[0035] In order to more clearly illustrate the technical solutions in the embodiments of the present application or the prior art, the accompanying drawings needed to be used in the embodiments or prior art description will be briefly introduced. Obviously, the accompanying drawings in the following description are some embodiments of the present application, and other drawings can be obtained by those skilled in the art without any creative effort based on these drawings.

[0036] Figure 1 is a perspective structural schematic diagram of a biological sample storage device according to an exemplary embodiment of the present application;

[0037] Figure 2 is an axial structural schematic diagram of a biological sample storage device according to an exemplary embodiment of the present application;

[0038] Figure 3 is a perspective structural schematic diagram of a multi-well mesh plate type storage area according to an exemplary embodiment of the present application;

[0039] Figure 4 is an axial structural schematic diagram of a multi-well mesh plate type storage area according to an exemplary embodiment of the present application;

[0040] Figure 5 is a structural schematic diagram of a plate rack type storage area according to an exemplary embodiment of the present application;

[0041] Figure 6 is a structural schematic diagram of a blood bag box storage area according to an exemplary embodiment of the present application;

[0042] Figure 7 is a structural schematic diagram of a disc piece storage area according to an exemplary embodiment of the present application;

[0043] Figure 8 is a structural schematic diagram of a biological sample storage device management system according to an exemplary embodiment of the present application.

[0044] Reference signs:

[0045] 1, 2ml cryogenic tube; 2, 0.5ml cryogenic tube; 3, 48-well 2ml cryogenic tube plate rack; 4, 96-well 0.5ml cryogenic tube plate rack; 5, 10x10 standard plate rack; 6, fan-shaped disc piece; 7, blood bag box; 81, sample information management module; 82, environmental parameter monitoring module; 83, operation record module; 84, alarm module; 85, user authority management module. DETAILED DESCRIPTION

[0046] In order to make the purposes, implementations and advantages of the present application clearer, the following will clearly and completely describe the exemplary implementations of the present application in conjunction with the accompanying drawings of the exemplary embodiments of the present application. Obviously, the described exemplary embodiments are only a part of the embodiments of the present application, rather than all the embodiments of the present application. It should be understood that the specific embodiments described herein are only used to explain the present application, and are not intended to limit the present application.

[0047] It should be noted that the brief description of the terms in the present application is only for the convenience of understanding the subsequently described implementations, and is not intended to limit the implementations of the present application. Unless otherwise specified, these terms should be understood according to their ordinary and general meanings.

[0048] The terms "first", "second", "third", and the like in the specification and claims of the present application and the above drawings are used to distinguish similar or similar objects or entities, and do not necessarily mean to limit the specific order or sequence, unless otherwise specified. It should be understood that the terms used in this way can be interchanged under appropriate circumstances.

[0049] The terms "include" and "have" and any variations thereof are intended to cover but not exclusive inclusion, for example, a product or device including a series of components does not have to be limited to all the components clearly listed, but can include other components not clearly listed or inherent to these products or devices.

[0050] Before explaining the biological sample storage device provided by the embodiments of the present application, the application scenarios and implementation environments of the embodiments of the present application are introduced.

[0051] The early biological sample preservation method mainly relies on low-temperature refrigerators, liquid nitrogen tanks and other equipment. Although these devices can provide a certain low-temperature environment, the storage conditions are limited, and it is difficult to fully guarantee the activity and safety of the samples. With the rapid development of precision medicine, genomics, translational medicine and information big data, artificial intelligence, the demand for biological sample resources is also increasing. Biological samples are non-renewable resources, which are the basis for exploring the occurrence, diagnosis and distribution of diseases, and are also an important guarantee for disease prevention, intervention, control, diagnosis and treatment, and drug research and development.

[0052] The traditional storage system relying on manual racks and cryopreservation boxes has limited storage density due to insufficient structural gap and vertical space utilization, and it is difficult to meet the current requirements for efficient storage of biological samples. At the same time, most of the existing biological sample storage devices lack intelligent management systems, and cannot monitor sample information and storage environment parameters in real time, making it difficult to effectively manage and trace the sample storage process.

[0053] Therefore, there is an urgent need for a biological sample storage device and a management system thereof, which can improve space utilization, ensure sample safety and stability, and have intelligent management function.

[0054] Based on this, the present application provides a biological sample storage device and a management system thereof, which effectively improves space utilization, realizes ultra-high density storage, ensures sample safety and stability, and realizes intelligent management with the help of the management system, is suitable for long-term preservation of various biological samples, and provides an efficient and reliable sample storage solution for scientific research and medical fields.

[0055] Next, the technical solutions of the present application and how the technical solutions of the present application solve the above technical problems will be described in detail through embodiments and in combination with the drawings. The embodiments can be combined with each other, and the same or similar concepts or processes can not be described again in some embodiments. Obviously, the described embodiments are part of the embodiments of the present application, not all.

[0056] Figure 1 is a perspective structural schematic diagram of a biological sample storage device according to an exemplary embodiment of the present application.

[0057] In an exemplary embodiment, as shown in Figure 1 , a biological sample storage device is provided, which in this embodiment can include a multi-hole mesh plate type structure storage area, a plate frame storage area, a fan-shaped disc storage area, and a blood bag box storage area.

[0058] The multi-hole mesh plate type structure storage area includes a 2ml test tube storage area and a 0.5ml test tube storage area, which are arranged in high-density aluminum tubes of different sizes, wherein the 2ml test tube storage high-density aluminum tubes store 0.5ml test tube storage high-density aluminum tubes, and the inner wall of the high-density aluminum tube is coated with a polytetrafluoroethylene coating to increase lubrication and reduce the risk of test tube jamming.

[0059] The fan-shaped disc storage area is located below the multi-hole mesh plate type structure, and the discs can be composed of different materials such as copper, aluminum or ABS. Each disc can store 0.5ml cryogenic tubes 2 or 2.0ml cryogenic tubes 1 as a single whole plate, or can store mixed 0.5ml or 2.0ml cryogenic tubes.

[0060] The blood bag box storage area is uniformly distributed around the fan-shaped disc and is used to store 25ml blood bag boxes, 50ml blood bag boxes and 250ml blood bag boxes.

[0061] The plate frame of the plate frame storage area is made of aluminum alloy material, and the surface is treated by anodic oxidation with an oxide film thickness of 10-15 μm, which has good wear resistance and corrosion resistance. A plurality of air holes are provided on the plate frame, the diameter of the air holes is 3-5 mm, and the hole spacing is 8-10 mm to promote gas exchange in the storage environment.

[0062] Figure 2 is a schematic view of the axial structure of a biological sample storage device according to an exemplary embodiment of the present application, Figure 3 is a schematic view of the three-dimensional structure of a multi-hole mesh plate type storage area according to an exemplary embodiment of the present application, Figure 4 is a schematic view of the axial structure of a multi-hole mesh plate type storage area according to an exemplary embodiment of the present application, Figure 5 is a schematic view of the structure of a plate frame type storage area according to an exemplary embodiment of the present application, Figure 6 is a schematic view of the structure of a blood bag box type storage area according to an exemplary embodiment of the present application, Figure 7 is a schematic view of the structure of a disc type storage area according to an exemplary embodiment of the present application.

[0063] In some embodiments, as shown in Figure 2 , the specific structure of the storage device includes a multi-hole mesh plate type storage area, a plate frame type storage area, a fan-shaped disc type storage area, and a blood bag box type storage area.

[0064] As shown in Figure 3 and Figure 4 , the multi-hole mesh plate type storage area is one of the core parts of the device, and its specific structure is as follows: it contains 2ml test tube storage areas and 0.5ml test tube storage areas, which are arranged by corresponding specifications of high-density aluminum tubes. These high-density aluminum tubes are arranged in a regular and dense array, with a storage density of not less than 10 per square decimeter, to maximize the use of storage space.

[0065] The 0.5ml test tube storage high-density aluminum tubes are ingeniously stored between the 2ml test tube storage high-density aluminum tubes, achieving a compact layout of different specifications of test tube storage structures and improving the storage density.

[0066] In order to reduce the risk of test tube jamming during insertion and removal, a polytetrafluoroethylene coating is plated on the inner wall of the high-density aluminum tube, which has good lubricating properties, so that the test tube can smoothly enter and exit the aluminum tube, effectively ensuring the smooth operation of sample storage.

[0067] The top of the porous mesh plate structure is also provided with a storage area of 48-hole 2ml cryopreservation tube plate rack 3, 96-hole 0.5ml cryopreservation tube plate rack 4, and 10x10 standard plate rack 5, which facilitates the storage and use of different specifications of test tube plate racks, and further improves the flexibility and versatility of the storage device.

[0068] The porous mesh plate structure adopts a double-layer reinforced design, and the bottom is provided with a metal support frame. The frame is spliced from aluminum alloy profiles, the profile cross section is rectangular, the wall thickness is 3mm to 5mm, and the support frame is connected to the main structure of the storage device through bolts. The strength grade of the connecting bolts is 8.8, to ensure the stability and carrying capacity of the porous mesh plate structure.

[0069] As shown in Figure 7 , the fan-shaped disc storage area is located at the lower part of the porous mesh plate structure. The disc can be composed of different materials such as copper, aluminum or ABS. The design of each fan-shaped disc 6 fully considers the actual needs of biological sample storage. It can store 0.5ml or 2.0ml cryopreservation tubes individually, or mix store 0.5ml or 2.0ml cryopreservation tubes, meeting the diversified storage requirements. The shape of the fan-shaped disc is a sector with a central angle of 45° to 90°, and the thickness is 3mm to 5mm. The surface is provided with anti-slip texture with a depth of 0.1mm to 0.2mm to improve the stability and operation safety of the disc. The disc is installed in the storage device through a rotating support. The rotating support is made of stainless steel material. The rotating shaft of the support has a diameter of 8mm to 10mm. The surface of the shaft is chrome plated, with a hardness of HRC55 to 60, ensuring that the disc can rotate flexibly and be used stably for a long time.

[0070] As shown in Figure 6 , the blood bag box storage area is evenly distributed around the fan-shaped disc, forming a ring-shaped layout. This layout makes full use of the space around the storage device, improving the space utilization. Each storage position in the blood bag box storage area is provided with an elastic fixing device made of silicone rubber material with an elastic coefficient of 0.1MPa to 0.3MPa, which can adapt to the size of different specifications of blood bag boxes, ensuring the stability of the blood bag box 7 during storage. The opening of the storage position is provided with a transparent cover plate made of high-strength polycarbonate material with a thickness of 3mm to 5mm. The cover plate is connected to the storage position through a hinge made of stainless steel, which has good corrosion resistance and reliability. It can not only protect the blood bag box from external pollution, but also facilitate observation and access.

[0071] As shown in Figure 5As shown, the shelves of the shelf storage area are made of aluminum alloy material, the surface is treated by anodic oxidation, the thickness of the oxidation film is 10-15 μm, and the shelves have good wear resistance and corrosion resistance. A plurality of air holes are arranged on the shelves, the diameter of the air holes is 3-5 mm, and the hole spacing is 8-10 mm to promote gas exchange in the storage environment. The shelves are installed in the storage device through adjustable support columns, the diameter of the support columns is 15-20 mm, the length is adjustable in the range of 100-200 mm, the adjustment accuracy is 1 mm, the material of the support columns is stainless steel, and the surface is polished to a roughness Ra≤0.8 μm to ensure the stability and adjustability of the shelves and meet the installation requirements of shelves of different heights.

[0072] It should be understood that, although the steps in the flowcharts involved in the above embodiments are displayed in sequence as indicated, these steps are not necessarily executed in the order as indicated. Unless otherwise specified herein, the execution of these steps is not strictly limited in sequence, and these steps can be executed in other orders. Moreover, at least part of the steps in the flowcharts involved in the above embodiments can include multiple steps or stages, which are not necessarily executed at the same time, but can be executed at different times, and the execution sequence of these steps or stages is not necessarily sequential, but can be executed in rotation or alternation with at least part of other steps or steps or stages in other steps.

[0073] Corresponding to the above-mentioned embodiments of the biological sample storage device, the present application also provides embodiments of a biological sample storage device management system.

[0074] Figure 8 is a structural schematic diagram of a biological sample storage device management system according to an exemplary embodiment of the present application.

[0075] In an exemplary embodiment, as shown in Figure 8 the biological sample storage device management system includes a sample information management module 81, an environmental parameter monitoring module 82, an operation record module 83, and an alarm module 84.

[0076] The sample information management module is used to store and query the basic information, storage location, and state information of the sample.

[0077] In some embodiments, the basic information, storage location and state information of the sample includes sample number, name, type, collection time, collection location, project to which the sample belongs, storage location coordinates, storage-in time, storage-out time, sample state (normal, abnormal, expired, etc.), the module uses a relational database for data storage, the database supports multi-user concurrent access, has data backup and recovery functions, and ensures the safety and integrity of the data.

[0078] The environmental parameter monitoring module is used for real-time monitoring of temperature, humidity and gas composition in the storage device, and transmitting data to the monitoring terminal.

[0079] The operation recording module is used for recording the time, operator and operation content of the opening, closing, sample access and other operations of the storage device.

[0080] The alarm module sends an audible and visual alarm signal when the environmental parameters exceed the preset range or an abnormal situation occurs, and sends alarm information to the preset mobile terminal.

[0081] Further, the present application also includes a user permission management module 85, which uses a multi-level permission management mechanism to divide users into three levels of administrator, operator and visitor, different levels of users have different operation permissions and data access permissions, the administrator can perform system settings, user management, data backup and recovery and other operations; the operator can perform sample access, daily maintenance, environmental parameter setting and other operations; the visitor can only perform limited information query. When logging into the system, the user needs to perform identity verification, the verification methods include username and password, fingerprint recognition, facial recognition and other methods, to ensure the security of the system and the confidentiality of the data.

[0082] In some embodiments, the management system specifically includes a sample information management module, an environmental parameter monitoring module, an operation recording module, an alarm module and a user permission management module.

[0083] The sample information management module is used for storing and querying the basic information, storage location and state information of the sample, including sample number, name, type, collection time, collection location, project to which the sample belongs, storage location coordinates, storage-in time, storage-out time, sample state, etc., the module uses a relational database for data storage, the database supports multi-user concurrent access, has data backup and recovery functions, and ensures the safety and integrity of the data.

[0084] The environmental parameter monitoring module is used to monitor the temperature, humidity and gas composition in the storage device in real time and transmit the data to the monitoring terminal. The temperature sensor is made of high-precision thermistor material, with a measurement accuracy of ±0.1℃ and a response time of 1s to 2s. The humidity sensor is based on the capacitive measurement principle, with a measurement accuracy of ±2%RH and a response time of 3s to 5s. The gas sensor is used to detect the concentration of oxygen, carbon dioxide and other gases, with a measurement accuracy of ±0.5% and a response time of 5s to 8s. Each sensor is uniformly distributed inside the storage device to ensure the accuracy and representativeness of the monitoring data. The monitoring terminal can display the environmental parameter curve and data table in real time and has historical data query and analysis functions.

[0085] The operation recording module is used to record the time, operator and operation content of the opening, closing and sample access operations of the storage device. The system automatically records the relevant information and stores it in the operation log database each time the operation is triggered. The operation log supports filtering and querying according to time, operator, operation type and other conditions, making it easy for management personnel to trace and audit the operation process of the storage device.

[0086] The alarm module sends an audible and visual alarm signal when the environmental parameters exceed the preset range or abnormal conditions occur, and sends alarm information to the preset mobile terminal. The alarm threshold can be flexibly set according to the storage requirements of different samples, such as setting the temperature alarm threshold to -20℃ ±2℃, the humidity alarm threshold to 30%RH to 70%RH, etc. The alarm information includes alarm time, alarm type, alarm location and other detailed content, ensuring that management personnel can receive the alarm in time and take appropriate measures.

[0087] The user permission management module adopts a multi-level permission management mechanism, dividing users into three levels: administrator, operator and visitor. Different levels of users have different operation permissions and data access permissions. The administrator can perform system settings, user management, data backup and recovery operations; the operator can perform sample access, routine maintenance, environmental parameter setting operations; the visitor can only perform limited information queries. User login to the system requires identity verification, including username and password, fingerprint recognition, facial recognition and other methods, ensuring the security of the system and the confidentiality of the data.

[0088] In actual application, the staff enters sample information through the management system, including sample number, name, type, collection time and other detailed information, and assigns appropriate storage positions for the samples according to the layout of the storage device.

[0089] When a sample needs to be stored, the staff places the sample into the designated storage location according to the system prompt, and the management system automatically updates the storage state and location information of the sample. At the same time, the environmental parameter monitoring module monitors the temperature, humidity and other environmental parameters in the storage device in real time, and transmits the data to the monitoring terminal.

[0090] The manager can view the environmental parameter curve and data table in real time through the monitoring terminal to ensure that the storage environment meets the sample preservation requirements. If the environmental parameters are abnormal, the alarm module immediately sends an audible and visual alarm signal and sends alarm information to the preset mobile terminal to remind the manager to take timely measures.

[0091] All operation records, including sample access, environmental parameter setting, alarm handling, etc., will be recorded in detail by the operation record module for subsequent tracing and auditing. Through the user permission management module, the system ensures that only authorized personnel can perform corresponding operations, ensuring the security of sample information and stable operation of the system.

[0092] It can be seen that the biological sample storage device and its management system provided by some embodiments of the present application have many advantages in practical application.

[0093] On the one hand, through innovative structural design, efficient storage of different specifications and types of biological samples is achieved, improving storage density and space utilization.

[0094] On the other hand, with the help of intelligent management system, fine management and monitoring of the whole sample storage process are realized, improving the safety and reliability of sample storage.

[0095] The device and its management system provide a comprehensive and intelligent solution for long-term preservation and effective utilization of biological samples, with broad application prospects and important practical significance.

[0096] It should be understood that the technical solutions in the embodiments of the present application can be realized by means of software and necessary general hardware platforms. Therefore, the technical solutions in the embodiments of the present application can be embodied in the form of a software product, which can be stored in a computer readable storage medium.

[0097] The technical features of the above embodiments can be combined arbitrarily. To make the description concise, all possible combinations of the technical features in the above embodiments are not described, but as long as the combination of the technical features does not exist contradictory, it should be considered as the scope of the present application.

[0098] The above embodiments only express several implementation ways of the present application, and the description is specific and detailed, but it should not be understood as a limitation to the patent scope of the application. It should be pointed out that for ordinary skilled in the art, without departing from the concept of the present application, several modifications and improvements can be made, which are all within the protection scope of the present application. Therefore, the protection scope of the patent of the present application should be subject to the appended claims.

Claims

1. A biological sample storage device, characterized in that, This includes a perforated mesh plate storage area, a rack storage area, a fan-shaped disk storage area, and a blood bag box storage area; The porous mesh structure storage area includes a 2ml test tube storage area and a 0.5ml test tube storage area, which are formed by a closed arrangement of high-density aluminum tubes of different sizes. The gaps between the 2ml test tubes store the 0.5ml test tubes. The inner wall of the high-density aluminum tubes is coated with polytetrafluoroethylene. The high-density aluminum tubes in the porous mesh structure storage area are arranged in a regular and dense array, with an arrangement density of no less than 10 storage positions per square decimeter to maximize the use of storage space. The outer wall of the high-density aluminum tubes is provided with a reinforcing rib structure. The cross-sectional shape of the reinforcing rib is triangular, and the height is 1 / 5 to 1 / 4 of the outer diameter of the aluminum tube to enhance the structural strength of the aluminum tube and prevent deformation. The top of the porous mesh plate structure storage area is equipped with storage areas for 2ml 48-well test tube plate racks, 0.5ml 96-well test tube plate racks, and 10×10 standard test tube plate racks; The racks in the rack storage area are made of aluminum alloy and have been anodized. The oxide film thickness is 10μm to 15μm, which has good wear resistance and corrosion resistance. The racks are provided with multiple ventilation holes with a diameter of 3mm to 5mm and a spacing of 8mm to 10mm to promote gas exchange in the storage environment. The fan-shaped disk storage area is located at the bottom of the porous mesh structure storage area. The disks can be made of different materials such as copper, aluminum or ABS. Each disk can store 0.5ml or 2.0ml cryovials individually or in combination. The fan-shaped disks are fan-shaped with a central angle of 45° to 90° and a thickness of 3mm to 5mm. The surface is provided with anti-slip texture with a texture depth of 0.1mm to 0.2mm to improve the stability and operational safety of the disks. The blood bag storage area is evenly distributed around the fan-shaped plate and is used to store 25ml blood bags, 50ml blood bags and 250ml blood bags.

2. The biological sample storage device as described in claim 1, characterized in that, Each storage slot in the blood bag box storage area is equipped with an elastic fixing device. The elastic fixing device is made of silicone rubber material with an elastic coefficient of 0.1MPa to 0.3MPa, which can adapt to the size of blood bag boxes of different specifications and ensure the stability of the blood bag boxes during storage.

3. A biological sample storage device management system, applied to the biological sample storage device as described in any one of claims 1 and 2, characterized in that, It includes a sample information management module, an environmental parameter monitoring module, an operation log module, and an alarm module; The sample information management module is used to store and query the basic information, storage location, and status information of samples. The environmental parameter monitoring module is used to monitor the temperature, humidity and gas composition in the storage device in real time and transmit the data to the monitoring terminal. The operation recording module is used to record the time, operator, and operation content of the storage device's opening and closing, sample access operations, and sample storage and retrieval operations. The alarm module emits an audible and visual alarm signal when environmental parameters exceed a preset range or when an abnormal situation occurs, and sends alarm information to a preset mobile terminal.

4. The biological sample storage device management system as described in claim 3, characterized in that, It also includes a user permission management module, which adopts a multi-level permission management mechanism to divide users into three levels: administrator, operator and visitor. Different levels of users have different operation permissions and data access permissions. Administrators can perform system settings and user management operations. Operators can perform sample storage and retrieval, and routine maintenance. Visitors are only allowed limited access to information to ensure system security and data confidentiality.

5. The biological sample storage device management system as described in claim 3, characterized in that, The environmental parameter monitoring module includes multiple temperature sensors, humidity sensors, and gas sensors; The temperature sensor is made of high-precision resistance thermal material, with a measurement accuracy of ±0.1℃ and a response time of 1s to 2s; The humidity sensor is based on the capacitive measurement principle, with a measurement accuracy of ±2%RH and a response time of 3s to 5s. The gas sensors are used to detect the concentration of oxygen and carbon dioxide, with a measurement accuracy of ±0.5% and a response time of 5 to 8 seconds. The sensors are evenly distributed inside the storage device to ensure the accuracy and representativeness of the monitoring data.

6. The biological sample storage device management system as described in claim 3, characterized in that, The storage device adopts a double-layer structure design. The outer layer is an insulation layer made of polyurethane foam with a thickness of 50mm to 80mm, which has good heat insulation performance. The inner layer is a storage layer with multiple partitions inside. The partitions are removable, and the layout of the storage area can be flexibly adjusted according to different sample storage needs. The bottom of the storage device is equipped with a movable base with four universal wheels. The universal wheels have a self-locking function, which facilitates the movement and fixation of the storage device.

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