Collecting device of helicobacter pylori detector based on carbon 14 enrichment principle

Abstract

The invention discloses a helicobacter pylori detector collecting device based on a C14 enrichment principle, which is provided with an upper clamping shell and a lower clamping shell, and the upper clamping shell and the lower clamping shell are clamped through a buckle to form a clamping body; the upper clamping shell is provided with an upper detection window and an indication window; an air blowing opening is formed in the front end of the lower clamping shell, a multi-channel guide air groove is formed in the lower clamping shell, a lower detection window is formed in the lower clamping shell, the upper detection window and the lower detection window form an alkaline 3D particle filling area, the alkaline 3D particle filling area is filled with alkaline 3D particles, and the guide air groove penetrates through the air blowing opening to the lower detection window. A front dehumidification filter element is installed in the middle section of the guide air groove, a color developing agent groove is further formed between the front dehumidification filter element and the lower detection window, an air outlet is formed in the rear end of the lower clamping shell, and a rear dehumidification filter element is arranged between the air outlet and the lower detection window. The CO2 reaction and adsorption area is practically and effectively increased, the detection precision is improved, the production process is greatly simplified, and the production cost is reduced.

Description

Technical Field

[0001] The present invention relates to a 14 CO2 adsorption principle 14 C Helicobacter pylori breath detection technology field, specifically a method that can improve adsorption efficiency, simplify production process, and reduce production costs 14 C Breath test collection device. Background Art

[0002] Helicobacter pylori is a spiral-shaped, Gram-negative, microaerophilic bacterium that colonizes the human gastric mucosa, its sole host. All H. pylori strains produce large amounts of urease, a primarily cytoplasmic enzyme that catalyzes the hydrolysis of urea into ammonia and carbon dioxide. The ammonia product neutralizes gastric acid, thereby helping H. pylori survive in the acidic environment of the stomach and stimulating bacterial protein synthesis.

[0003] urea 14 The C breath test is a diagnostic test that analyzes the amount of urea a patient takes orally. 14 The respiratory samples before and after C are used to diagnose whether the patient's stomach is infected with Helicobacter pylori. Under the action of Helicobacter pylori urease, urea 14 C decomposes into 14 CO2 and NH3:

[0004]

[0005] 14 CO2 is absorbed into the lungs through the blood and then exhaled out of the body. 14 CO2 absorption and distribution are fast, when urea is taken 14 After C, Helicobacter pylori immediately breaks it down into 14 CO2, thus quickly detecting the increased exhaled gas in patients with Helicobacter pylori 14 CO2. However, since the stomach of Helicobacter pylori negative patients does not contain urease that breaks down urea, urea 14 C is not produced in the stomach 14 Therefore, by collecting the patient's exhaled gas, the CO2 14 The CO2 level can be used to diagnose Helicobacter pylori infection in the stomach. This test, painless, non-invasive, quick and easy, and without cross-infection, has been unanimously recommended by experts both domestically and internationally as the gold standard for diagnosing H. pylori and has been widely used in clinical practice.

[0006] In the prior art, there are many documents and patents related to 14C Breath test card. In a Chinese patent application with publication number CN208031231 U, entitled "A Helicobacter pylori detector breath card," it is proposed that an indicator sheet be placed within the air outlet channel to prevent the subject's exhaled gas from being absorbed by the indicator sheet before entering the breath card absorber, thereby affecting the absorber's adsorption efficiency. Furthermore, a slotted indicator sheet structure provides more accurate indication of breath card sampling. The whistle-style air outlet employed by this device facilitates the subject and test personnel to understand the amount of exhaled gas through a low-pitched whistle, thereby further improving the sampling efficiency and accuracy of the breath card. However, the patent does not address methods for improving the collection efficiency of breath cards.

[0007] In a Chinese patent application titled "A Breath Sample Collection Card," published with application number CN218240050 U, a technical solution is proposed for further securing the breath collection card and the mouthpiece through a snap-fit ​​mechanism. This mechanism provides an interference fit and further enhances the secure connection, preventing the card from being blown away even when the user is not holding the card. However, the patent also fails to address the issue of improving the collection efficiency of the breath collection card. Summary of the Invention

[0008] In order to overcome the problems existing in the prior art, the present invention proposes a method of filling a 3D particle structure with an alkaline substance (capable of adsorbing CO2) 14 C breath detection collection device, this structure effectively increases the CO2 reaction and adsorption area, improves detection accuracy, greatly simplifies the production process and reduces production costs.

[0009] In order to achieve the above-mentioned object of the invention, the present invention adopts the following technical solutions:

[0010] A Helicobacter pylori detector and collection device based on the carbon 14 enrichment principle.

[0011] Specifically: an alkaline substance (capable of adsorbing CO2) filled with a 3D particle structure 14 C Breath test collection device;

[0012] It consists of an exhalation card and a mouthpiece. The exhalation card features a detection window. The front and back of the detection window are covered with a transparent film to secure the alkaline substance in a 3D particle structure. The main structure of the exhalation card features a multi-channel air guide slot that runs from the mouthpiece to the detection window. A dehumidification filter is installed in the middle of the slot to absorb moisture from the subject's exhaled breath, reducing contamination of the alkaline substances in the detection area. It also prevents backdrafts, preventing alkaline substances from being inhaled into the subject's mouth. The card body and the mouthpiece are connected using a snap-fit ​​mechanism.

[0013] The dehumidification filter element is preferably made of polypropylene fiber or cellulose acetate. This material is a safe and non-toxic macromolecular material with excellent filtration performance, widely used in food packaging. Its good biocompatibility makes it suitable for the pharmaceutical and medical industries. This filter element can effectively remove moisture from exhaled breath while preventing alkaline substances from being inhaled into the patient's mouth.

[0014] Preferably, the multi-channel guide air groove extends to the detection area (carbon dioxide adsorption area) after passing through the dehumidification filter area, and then converges to the air outlet. The filter area is also set at the air outlet to prevent alkaline substances from being exhaled out of the gas collection card.

[0015] Preferably, the color developer is one of phenolphthalein, thymolphthalein, trinitrotoluene, tropaeolum orange, and curcumin, and its purpose is to change the color of the color card to prompt the tester that the exhalation step is completed.

[0016] Preferably, the alkaline substance particles are lithium hydroxide or calcium hydroxide, which are filled into the detection area in a round particle mode or a columnar particle mode. The particle filling method can effectively increase the CO2 adsorption area, thereby improving the collection efficiency of the gas collection card.

[0017] Compared with the prior art, the present invention has the following beneficial effects:

[0018] The present invention provides a 14 The Helicobacter pylori detector collection device is based on the principle of CO2 enrichment. This device effectively increases the CO2 reaction and adsorption area, improves detection accuracy, greatly simplifies the production process and reduces production costs. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 It is a schematic diagram of the upper shell structure of the present invention;

[0020] Figure 2 This is a schematic diagram of the internal structure of the lower shell of the present invention;

[0021] Figure 3 This is a bottom view of the lower shell filled with alkaline 3D particles of the present invention.

[0022] In the figure: 1. Upper shell; 2. Lower shell; 3. Air outlet; 4. Front dehumidification filter element; 5. Guide air slot; 6. Developer slot; 7. Rear dehumidification filter element; 8. Buckle; 9. Alkaline 3D particles; 10. Upper detection window; 11. Lower detection window; 12. Indicator window; 13. Air outlet. DETAILED DESCRIPTION

[0023] To make the objectives, technical solutions, and advantages of the embodiments of the present invention more clear, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts shall fall within the scope of protection of the present invention.

[0024] In the description of the present invention, it should be understood that the terms "upper", "lower", "front", "back", "left", "right", "top", "bottom", "inside", "outside", etc., indicating directions or positional relationships, are relative relationships of directions or positions, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific direction, be constructed and operated in a specific direction, and therefore cannot be understood as limiting the present invention.

[0025] See also Figure 1-3 , an embodiment provided by the present invention: This embodiment discloses an alkaline substance (capable of adsorbing CO2) filled with a 3D three-dimensional particle structure 14 C breath detection collection device, which effectively increases the CO2 reaction and adsorption area, improves detection accuracy, greatly simplifies the production process and reduces production costs.

[0026] The device comprises an upper and a lower card shell 1, 2, which are connected by a snap 8 to form a card body; the upper card shell 1 is provided with an upper detection window 10 and an indication window 12, and the upper surface of the upper detection window 10 is covered with a transparent film; the front end of the lower card shell 2 is provided with an air blowing port 3, and the interior of the lower card shell 2 is provided with a multi-channel guide air groove 5, and the interior of the lower card shell 2 is provided with a lower detection window 11, and the position of the lower detection window 11 corresponds to the upper detection window 10 of the upper card shell, and the lower surface of the lower detection window 11 is covered with a transparent film. The upper and lower detection windows constitute an alkaline 3D particle filling area, and the alkaline 3D particle filling area is filled with alkaline 3D particles 9. The guide air groove 5 runs through the air outlet 3 to the lower detection window 11. A front dehumidification filter element 4 is installed in the middle section of the guide air groove 5. A color developer groove 6 is also provided between the front dehumidification filter element 4 and the lower detection window 11. The color developer groove 6 corresponds to the position of the indication window 12 of the upper card shell. An air outlet 13 is opened at the rear end of the lower card shell 2, and a rear dehumidification filter element 7 is provided between the air outlet 13 and the lower detection window 11.

[0027] Preferably, the dehumidification filter element is made of polypropylene fiber or acetate fiber, made into a cylinder or a cuboid and clamped in the guide air groove.

[0028] Preferably, the multi-channel guide air groove extends to the alkaline 3D particle filling area after passing through the front dehumidification filter area, the alkaline 3D particle filling area is the carbon dioxide adsorption area, and then converges to the air outlet, where a rear dehumidification filter is provided.

[0029] Preferably, the color developer is one of phenolphthalein, thymolphthalein, trinitrotoluene, tropaeolum orange, and curcumin.

[0030] Preferably, the alkaline 3D particles are lithium hydroxide or calcium hydroxide, which are filled into the alkaline 3D particle filling area in a round particle mode or a columnar particle mode.

[0031] When in use, the collecting device is in the shape of a card, which is composed of two open mold sheets spliced ​​together by a buckle 8. The filled 3D alkaline particles can be observed through the alkaline 3D particle filling area on the outside of the card.

[0032] After the patient holds his breath, he blows the lung gas into the test card through the blowing port 3.

[0033] The airflow passes through the front dehumidification filter element 4, enters the guide air groove 5, and then enters the alkaline 3D particle filling area through the color developer 6. The CO2 gas in the exhaled air reacts chemically with the 3D alkaline particles 9 and adsorbs on the surface of the particles. The exhaled air is finally discharged from the card through the dehumidification filter element 7.

[0034] The above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit the same. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or make equivalent replacements for some of the technical features therein. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the various embodiments of the present invention.

Claims

1. A Helicobacter pylori detector and collection device based on the carbon 14 enrichment principle, characterized by: The cam is provided with a plurality of guide air grooves, each of which is provided with a plurality of guide air grooves, each of which is provided with a plurality of guide air grooves, each of which is provided with a plurality of guide air grooves.

2. The Helicobacter pylori detector and collection device based on the carbon 14 enrichment principle according to claim 1, characterized in that: The dehumidification filter element is made of polypropylene fiber or acetate fiber, is made into a cylinder or a rectangular parallelepiped and is clamped in the guide air groove.

3. The Helicobacter pylori detector and collection device based on the carbon 14 enrichment principle according to claim 1, characterized in that: The multi-channel guide air groove passes through the front dehumidification filter area and extends to the alkaline 3D particle filling area, which is the carbon dioxide adsorption area, and then converges to the air outlet, where the rear dehumidification filter is provided.

4. The Helicobacter pylori detector and collection device based on the carbon 14 enrichment principle according to claim 1, characterized in that: The color developer is one of phenolphthalein, thymolphthalein, trinitrotoluene, tropaeolum orange, and curcumin.

5. The Helicobacter pylori detector and collection device based on the carbon 14 enrichment principle according to claim 4, characterized in that: The alkaline 3D particles are lithium hydroxide or calcium hydroxide, and are filled into the alkaline 3D particle filling area in a round particle mode or a columnar particle mode.

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