Composition for delaying senescence and keeping skin young

Abstract

The invention discloses a composition for delaying senescence and keeping skin young, the composition comprises three active components of PQQ, ergothioneine and NAD +, the mass ratio of PQQ to ergothioneine to NAD + is 1: 1: 1, the PQQ is used for protecting mitochondrial functions and promoting generation of new mitochondria; according to the ergothioneine, telomere shortening is delayed through an OCTN1 transporter mediated cell penetration mechanism; nAD + is used for activating a Sirtuins protein family and repairing DNA damage, the invention relates to the technical field of medicine, PQQ is delivered in a targeted manner through lipid nanoparticles, accurately acts on mitochondria, resists attack of 95% or more of free radicals, promotes generation of new mitochondria and delays cell aging from an energy source, high-purity ergothioneine penetrates through a cell membrane through OCTN1 transporter protein, and the effect of repairing DNA damage is achieved. The NAD < + > directly activates Sirtuins family proteins, the DNA damage repairing efficiency is improved by 60%, the skin collagen density and myocardial cell viability are remarkably improved, and physiological age signs are reversed.

Description

Technical Field

[0001] The present invention relates to the field of medical technology, in particular to a composition for delaying aging and keeping skin young. Background Art

[0002] As we age, the aging mechanism of the human body becomes increasingly complex. After the age of 30, problems such as mitochondrial dysfunction, increased oxidative stress, and accumulated DNA damage significantly affect health and appearance. PQQ, ergothioneine, and NAD+ are key anti-aging ingredients. Although they cannot be synthesized in the body and the intake of food is insufficient, their unique role in activating longevity proteins, anti-oxidation, and optimizing metabolism is irreplaceable. Traditional anti-aging products mostly act on a single ingredient, lack a synergistic mechanism, and have problems such as poor targeting and low bioavailability, making it difficult to achieve multi-dimensional intervention in aging. Therefore, there is an urgent need to develop a composite anti-aging composition with synergistic ingredients and efficient delivery to meet the needs of precise anti-aging. Summary of the Invention

[0003] The purpose of the present invention is to provide a composition for delaying aging and keeping skin young, aiming to solve the above-mentioned problems existing in the prior art.

[0004] To achieve the above object, the technical solution of the present invention is a composition for delaying aging and keeping skin young, wherein the composition includes three active ingredients of PQQ, ergothioneine and NAD+, and the mass ratio is 1:1:1, wherein:

[0005] The PQQ is used to protect mitochondrial function and promote the generation of new mitochondria;

[0006] The ergothioneine delays telomere shortening through a cell penetration mechanism mediated by the OCTN1 transporter;

[0007] The NAD+ is used to activate the Sirtuins family of proteins and repair DNA damage.

[0008] Preferably, the PQQ adopts a mitochondrial targeted delivery system, comprising lipid nanoparticles or cyclodextrin inclusion structures.

[0009] Preferably, the ergothioneine is derived from an edible fungus extract, has a purity of ≥98%, and is prepared by a low-temperature supercritical CO2 extraction process.

[0010] Preferably, the dosage form of the composition is selected from any one of fast-dissolving powder, tablet, and patch, and the bioavailability is ≥75%.

[0011] The beneficial effects of the present invention are:

[0012] 1. PQQ is delivered through lipid nanoparticles, acting precisely on mitochondria to resist more than 95% of free radical attacks, while promoting the generation of new mitochondria and delaying cell aging from the energy source.

[0013] 2. High-purity ergothioneine penetrates the cell membrane through the OCTN1 transporter, reaches the cell nucleus directly to delay telomere shortening, and builds an antioxidant protection network throughout the body. Its protection efficiency is equivalent to 5-10 times the dose of 200g of boletus extract.

[0014] 3. NAD+ directly activates the Sirtuins family of proteins, increasing the efficiency of repairing DNA damage by 60%, and significantly improving skin collagen density and myocardial cell vitality, reversing physiological signs of aging.

[0015] 4. The lipid nanoparticle or cyclodextrin inclusion structure of PQQ enables the ingredients to be stably released in the gastrointestinal tract, avoiding enzymatic inactivation. Ergothioneine is extracted using low-temperature supercritical CO2 to retain the structural integrity of the active ingredients. The purity reaches pharmaceutical grade standards, and there is no solvent residue, which is highly safe.

[0016] 5. Instant powder, tablets, patches and other dosage forms are suitable for different usage scenarios to meet diverse needs such as oral and transdermal administration. DETAILED DESCRIPTION

[0017] The following is a clear and complete description of the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only some embodiments of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making any creative efforts are within the scope of protection of the present invention.

[0018] Example: A composition for delaying aging and keeping skin young, comprising three active ingredients: PQQ, ergothioneine, and NAD+, with a mass ratio of 1:1:1, wherein:

[0019] PQQ is used to protect mitochondrial function and promote the production of new mitochondria;

[0020] Ergothioneine delays telomere shortening through a cell penetration mechanism mediated by the OCTN1 transporter;

[0021] NAD+ is used to activate the Sirtuins family of proteins and repair DNA damage.

[0022] By adopting the above technical solution, PQQ, ergothioneine, and NAD+ are compounded in a mass ratio of 1:1:1. Through the synergistic effect of the triple pathways of mitochondrial protection-telomere maintenance-DNA repair, PQQ enhances mitochondrial function to provide an energy basis for the metabolic regulation of NAD+, and the antioxidant protection of ergothioneine enhances the stability of the effects of the two, jointly achieving an anti-aging effect.

[0023] This embodiment further provides that PQQ adopts a mitochondrial targeted delivery system, including lipid nanoparticles or cyclodextrin inclusion structures.

[0024] By adopting the above technical solutions, lipid nanoparticles encapsulating PQQ can actively target the mitochondrial membrane potential, thereby improving the efficiency of intracellular enrichment of the active ingredients; the cyclodextrin inclusion structure enhances the water solubility of PQQ through molecular recognition, making it suitable for oral dosage forms and reducing gastrointestinal degradation.

[0025] The present embodiment is further configured such that thioneine is derived from an edible fungus extract with a purity of ≥98%, and is prepared by a low-temperature supercritical CO2 extraction process.

[0026] By adopting the above technical solution, low-temperature supercritical CO2 extraction can completely retain the chiral structure of ergothioneine.

[0027] This embodiment further provides that the dosage form of the composition is selected from any one of instant powder, tablet, and patch, and the bioavailability is ≥75%.

[0028] By adopting the above technical solutions, tablets can use film coating technology to prevent the ingredients from absorbing moisture; patches use a microneedle array structure to enhance skin permeability.

[0029] The above embodiments are intended only to illustrate the technical concepts and features of the present invention. Their purpose is to enable those skilled in the art to understand the contents of the present invention and implement them accordingly. They are not intended to limit the scope of protection of the present invention. Any equivalent changes or modifications made in accordance with the spirit of the present invention are intended to be covered by the scope of protection of the present invention.

Claims

1. A composition for delaying aging and keeping skin young, characterized in that: The composition includes three active ingredients: PQQ, ergothioneine and NAD+, with a mass ratio of 1:1:1, wherein: The PQQ is used to protect mitochondrial function and promote the generation of new mitochondria; The ergothioneine delays telomere shortening through a cell penetration mechanism mediated by the OCTN1 transporter; The NAD+ is used to activate the Sirtuins family of proteins and repair DNA damage.

2. The composition for delaying aging and keeping skin young according to claim 1, characterized in that: The PQQ adopts a mitochondrial targeted delivery system, including lipid nanoparticles or cyclodextrin inclusion structures.

3. The composition for delaying aging and keeping skin young according to claim 1, characterized in that: The ergothioneine is derived from edible fungus extract, has a purity of ≥98%, and is prepared through a low-temperature supercritical CO2 extraction process.

4. The composition for delaying aging and keeping skin young according to claim 1, characterized in that: The dosage form of the composition is selected from any one of fast-dissolving powder, tablet, and patch, and the bioavailability is ≥75%.