Wound repair nutrition supporting agent as well as preparation method and application thereof

Abstract

The invention belongs to the technical field of wound repairing agents, and particularly relates to a wound repairing nutrition supporting agent and a preparation method and application thereof. The wound repair nutrition supporting agent is prepared from the following raw materials in parts by weight: 7 to 10 parts of glutamine, 5 to 15 parts of branched chain amino acid, 10 to 15 parts of arginine, 0.3 to 0.6 part of beta-hydroxy-beta-methylbutyrate, 40 to 60 parts of whey protein powder, 5 to 8 parts of peptide raw materials, 6 to 9 parts of casein phosphopeptides, 0.2 to 0.5 part of radix notoginseng and 0 to 0.003 part of sulfate. The peptide raw material is soybean peptide powder or collagen peptide, and the sulfate is magnesium sulfate or copper sulfate. The anti-infection wound repair nutrition support agent disclosed by the invention has the effects of wound repair, nutrition support and anti-infection at the same time.

Description

Technical Field

[0001] The present invention belongs to the technical field of wound repair agents, and in particular relates to a wound repair nutritional support agent and a preparation method and application thereof. Background Art

[0002] Poor wound healing is a widespread medical problem affecting diverse populations and complex pathological mechanisms. With the aging population and shifting disease profiles, the number of patients with chronic, non-healing wounds is increasing annually, and the incidence of these wounds is rising. For example, among inpatients in orthopedic trauma departments, the proportion of patients with non-healing wounds ranges from 1.5% to 20.3%, with a trend that continues to increase annually. Causes of poor wound healing include infection, vascular disease, diabetes, malnutrition, and immune system abnormalities. These factors hinder wound healing, resulting in chronic, non-healing wounds. Poor wound healing is particularly common in the elderly, with malnutrition rates ranging from 29% to 31% in patients aged 65 to 80 and as high as 54% to 60% in those over 80. Malnourished patients experience longer hospital stays, delayed postoperative mobilization, and significantly higher rates of adverse events. Poor wound healing can also lead to delayed wound healing, increased infection risk, prolonged hospitalization, and increased medical costs. Nutritional support is an integral part of wound healing, meeting the patient's high metabolic demands and promoting tissue repair and immune recovery.

[0003] There are many people who need wound repair, such as (1) trauma patients: patients who suffer skin or tissue damage due to trauma, surgery, burns, etc., who need treatment and rehabilitation through wound repair technology; (2) chronic wound patients: patients with chronic wounds that are difficult to heal, such as diabetic foot, pressure sores, venous ulcers, and radiation ulcers. These patients need long-term wound repair and management; (3) the elderly: due to the weakening of tissue regeneration ability and poor blood circulation caused by aging, the elderly are a high-risk group for wound repair and chronic wounds; (4) long-term bedridden patients: due to long-term pressure on local skin, pressure injuries (bedsores) are prone to form and difficult to heal; (5) obese patients: thickened subcutaneous fat, poor blood circulation, prone to fat liquefaction and infection, and delayed wound healing; (6) malnourished people: lack of protein, vitamins and trace elements, which affects cell regeneration and tissue repair, resulting in poor wound healing; (7) immunocompromised people: such as AIDS patients or patients who use immunosuppressants for a long time, have low immunity, are prone to wound infection, and have delayed healing.

[0004] There are many products in the prior art that promote wound healing. For example, Chinese patent CN201711414355.5 provides a nutritional composition that promotes wound healing, pressure sore repair, and postoperative stress ulcer healing, shortening hospital stays, reducing medical expenses, and lowering mortality. This patent selectively regulates absorption speed through a combination of high and low molecular weight peptides, achieving rapid absorption and onset of action and slow release of effects, which synergistically promotes wound healing, pressure sore repair, and stress ulcer healing from physiological and psychological perspectives. Chinese patent CN201611228679.5 provides a liquid nutritional food that primarily provides transitional nutritional support for patients undergoing anti-infection treatment for trauma, burns, and postoperative surgery, in order to promote wound repair. Chinese patent CN202410396962.7 relates to a traditional Chinese medicine for burns and scalds and its preparation method, addressing the issues of existing burn and scald medications that require long treatment times and are prone to scarring.

[0005] Although existing technologies have developed some wound repair products from the perspectives of nutrition and wound healing, infection can delay wound healing, and some wounds are even caused by bacterial infection. Therefore, it is necessary to develop wound repair nutritional support agents that can resist infection. Summary of the Invention

[0006] In order to solve the above technical problems, the present invention provides a wound repair nutritional support agent and its preparation method and application.

[0007] The first object of the present invention is to provide a wound repair nutritional support agent, which is made from the following raw materials in parts by weight: 7 to 10 parts of glutamine, 5 to 15 parts of branched-chain amino acids, 10 to 15 parts of arginine, 0.3 to 0.6 parts of β-hydroxy-β-methylbutyrate (such as calcium β-hydroxy-β-methylbutyrate or sodium β-hydroxy-β-methylbutyrate), 40 to 60 parts of whey protein powder, 5 to 8 parts of peptide raw material; 0.2 to 0.25 parts of zinc (added in the form of zinc sulfate, zinc gluconate, zinc acetate or zinc citrate, calculated as parts by weight of zinc element), 6 to 9 parts of casein phosphopeptide, 0.2 to 0.5 parts of Panax notoginseng, and 0 to 0.003 parts of sulfate; the peptide raw material is soy peptide powder or collagen peptide, and the sulfate is magnesium sulfate or copper sulfate.

[0008] The present invention uses glutamine, branched-chain amino acids, arginine, β-hydroxy-β-methylbutyrate, whey protein powder, peptide raw materials, zinc, and casein phosphopeptide as nutrients, combines Panax notoginseng, nutrients, and sulfate to prepare a wound repair nutritional support agent with anti-infection effect.

[0009] Among them, Panax notoginseng has the following effects: (1) Promote wound healing: Panax notoginseng has the effect of promoting blood circulation and removing blood stasis, which can improve local blood circulation, provide more nutrition for damaged skin tissue, accelerate metabolism, and help the skin repair itself better; (2) Stop bleeding and relieve pain: Panax notoginseng can promote blood coagulation, help stop bleeding quickly, reduce the time and amount of bleeding from wounds, and also has the effect of reducing swelling and relieving pain; (3) Anti-inflammatory effect: The active ingredients in Panax notoginseng can inhibit inflammatory reactions, reduce inflammatory damage at the site of trauma, and create favorable conditions for wound healing; (4) Reduce scar formation: It helps to improve blood circulation at the scar site, reduce the redness and swelling of the scar, and make the scar look less obvious; (5) Antibacterial and antioxidant: The ingredients in Panax notoginseng have antibacterial and antioxidant effects, which can inhibit the formation of scars.

[0010] Nutrients provide comprehensive, integrated nutritional support for wound repair, accelerating wound healing and reducing scarring. For example, glutamine is a non-essential amino acid, particularly in response to stress or trauma. Glutamine is a crucial energy source for intestinal and immune cells, crucial for maintaining intestinal barrier function and immune responses, and indirectly promotes wound healing. Arginine is a conditionally essential amino acid, essential for wound healing. It can be converted into nitric oxide in the body, helping to improve local blood circulation and thus promote wound healing. The role of casein phosphopeptides: Casein phosphopeptides can promote cell growth and differentiation, thereby accelerating the wound healing process. Casein phosphopeptides are rich in phosphoserine, which effectively promotes the body's absorption and utilization of divalent mineral nutrients such as calcium, iron, and zinc, which are crucial for wound healing. Whey protein powder is rich in various amino acids, including branched-chain amino acids such as leucine, isoleucine, and valine. These amino acids form the basis of protein synthesis in the body and are crucial for wound repair and tissue growth. In the present invention, these nutrients can also enhance the antibacterial effects of Panax notoginseng.

[0011] Sulfates are orally safe copper sulfate and magnesium sulfate, which are known ingredients for preparing medicines. For example, magnesium sulfate is used to treat hypomagnesemia. In the present invention, sulfate is used for the first time to improve the ionic environment and enhance the antibacterial effect of Panax notoginseng.

[0012] Preferably, in the above-mentioned wound repair nutritional support agent, the Panax notoginseng is Panax notoginseng powder with a particle size of 100 mesh to 200 mesh.

[0013] The second object of the present invention is to provide a method for preparing the above-mentioned wound repair nutritional support agent, which comprises preparing various raw materials according to a weight ratio, mixing them, and obtaining the wound repair nutritional support agent.

[0014] The present invention provides an application of the above-mentioned wound repair nutritional support agent, which refers to a preparation for providing nutritional support, promoting wound repair and inhibiting bacteria.

[0015] Preferably, the application of the above-mentioned wound repair nutritional support agent, wherein the promotion of wound repair refers to shortening the wound healing time and reducing scars.

[0016] Preferably, the application of the above-mentioned wound repair nutritional support agent to promote wound repair means shortening the wound healing time and reducing scars.

[0017] The third object of the present invention is to provide the use of nutrients and sulfates in enhancing the antibacterial effect of Panax notoginseng, wherein the nutrients are glutamine, branched-chain amino acids, arginine, β-hydroxy-β-methylbutyrate, whey protein powder, peptide raw materials, zinc and casein phosphopeptide; the peptide raw materials are soybean peptide powder or collagen peptide, and the sulfate is magnesium sulfate or copper sulfate; and the nutrients, sulfates and Panax notoginseng are mixed according to the described weight parts to prepare a solid preparation.

[0018] Preferably, the above nutrients and sulfates are used to enhance the antibacterial effect of Panax notoginseng, and the weight portion of sulfate is 0.001 to 0.003 parts. Specifically, the weight portion of sulfate is 0.001 parts, the weight portion of sulfate is 0.0015 parts, the weight portion of sulfate is 0.002 parts, the weight portion of sulfate is 0.0025 parts, and the weight portion of sulfate is 0.003 parts.

[0019] Preferably, the above nutrients and sulfates are used to enhance the antibacterial effect of Panax notoginseng, wherein the antibacterial effect refers to the inhibitory effect on Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa and drug-resistant vancomycin-resistant enterococci.

[0020] Preferably, the above nutrients and sulfates are used to enhance the antibacterial effect of Panax notoginseng, and auxiliary materials are added when preparing solid preparations.

[0021] Excipients are fillers, sweeteners, flavoring agents or skin repair agents.

[0022] For example, starch can be used as a filler, lactose as a stabilizer and sweetener, sucrose as a sweetener, or juice powder as a flavoring agent. The juice powder can be orange powder, strawberry powder, or mint powder, and the added amount of juice powder is 1% to 1.5% of the solid dosage form. Another example is collagen as a skin repair agent.

[0023] Compared with the prior art, the present invention has the following beneficial effects: 1. The present invention uses glutamine, branched-chain amino acids, arginine, β-hydroxy-β-methylbutyrate, whey protein powder, peptide raw materials, zinc, and casein phosphopeptide as nutrients, combines Panax notoginseng, nutrients, and sulfate, and sets the following raw material ratio by weight: 7 to 10 parts of glutamine, 5 to 15 parts of branched-chain amino acids, 10 to 15 parts of arginine, 0.3 to 0.6 parts of β-hydroxy-β-methylbutyrate, 40 to 60 parts of whey protein powder, 5 to 8 parts of peptide raw materials, 0.2 to 0.25 parts of zinc, 6 to 9 parts of casein phosphopeptide, 0.2 to 0.5 parts of Panax notoginseng, and 0 to 0.003 parts of sulfate; the peptide raw material is soybean peptide powder or collagen peptide, and the sulfate is magnesium sulfate or copper sulfate. Nutrients provide comprehensive, integrated nutritional support for wound repair, accelerating wound healing, promoting muscle repair and synthesis, enhancing immunity, maintaining gastrointestinal health, reducing complications and infection rates, preventing bedsores, regulating metabolism, and reducing scarring. Panax notoginseng primarily exhibits antibacterial properties, and both nutrients and sulfates are used to enhance its antibacterial effects. Therefore, the present invention provides a nutritional support agent for wound repair that can resist infection.

[0024] 2. The present invention discovered for the first time that nutrients and sulfates can enhance the antibacterial effect of Panax notoginseng, providing a new anti-infection solution.

[0025] Pathogens that commonly cause wound infections include drug-resistant Staphylococcus aureus, drug-resistant Staphylococcus epidermidis, and drug-resistant Pseudomonas aeruginosa, as well as drug-resistant vancomycin-resistant Enterococci (VRE). Vancomycin-resistant Enterococci are the most difficult to control. Developing formulations that inhibit these bacteria is crucial. This invention addresses both nutritional support and antibacterial measures, providing patients with nutritional support such as protein and amino acids to enhance their own immunity. Panax notoginseng is also used as the primary antibacterial ingredient. Sulfate and other nutrients (glutamine, branched-chain amino acids, arginine, β-hydroxy-β-methylbutyrate, whey protein powder, peptide raw materials, zinc, and casein phosphopeptides) are also utilized to enhance Panax notoginseng's inhibitory ability against Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, and vancomycin-resistant Enterococci.

[0026] 4. The present invention exhibits antibacterial ability against vancomycin-resistant enterococci, which can prevent skin redness, swelling, pain, pus exudation and other problems caused by the bacteria, accelerate wound repair, reduce the occurrence of complications, and protect susceptible people.

[0027] 5. It should be further explained that the use of the wound repair nutritional support agent of the present invention mainly manifests in the following aspects: (1) Rapid tissue repair and muscle recovery can protect muscle tissue, reduce oxidative stress, and protect cells from loss; it can also promote muscle synthesis, reduce muscle breakdown, and reduce muscle consumption in trauma patients; it can also improve the nutritional status of trauma patients, accelerate the wound healing process, reduce muscle atrophy and bedsores, reduce the risk of complications, improve the quality of life of trauma patients, and enhance their ability to move. It shortens the recovery time of trauma repair patients.

[0028] (2) Enhance immunity, promote intestinal health, maintain intestinal mucosal barrier, increase intestinal tolerance, reduce intestinal permeability, prevent bacterial and toxin translocation, promote intestinal trauma repair, wound healing, increase protein synthesis rate, help maintain and restore muscle mass, and improve healing quality and speed.

[0029] (3) Regulate metabolism, improve the activity and function of immune cells, promote blood supply to the wound site and accelerate the healing process. Provide energy to support the body's needs during wound healing. Reduce the risk of infection and inflammation, and reduce infection complications. BRIEF DESCRIPTION OF THE DRAWINGS

[0030] Figure 1 This is the inventive concept map of the present invention. DETAILED DESCRIPTION

[0031] In order to enable those skilled in the art to better understand and implement the technical solution of the present invention, the present invention is further described below with reference to specific embodiments and drawings.

[0032] The technical solutions and effects of the present invention are described below with reference to some embodiments and experimental data.

[0033] In the description of the present invention, unless otherwise specified, all reagents used are commercially available and all methods used are conventional techniques in the art.

[0034] The inventive concept of the present invention is shown in Figure 1 ,as follows: (1) Provide a wound repair nutritional support agent, which is made from the following raw materials in parts by weight: 7-10 parts glutamine, 5-15 parts branched-chain amino acids, 10-15 parts arginine, 0.3-0.6 parts β-hydroxy-β-methylbutyrate, 40-60 parts whey protein powder, 5-8 parts peptide raw material, 6-9 parts casein phosphopeptide, 0.2-0.5 parts Panax notoginseng, and 0-0.003 parts sulfate; the peptide raw material is soy peptide powder or collagen peptide, and the sulfate is magnesium sulfate or copper sulfate. Glutamine, branched-chain amino acids, arginine, β-hydroxy-β-methylbutyrate, whey protein powder, peptide raw material, zinc, and casein phosphopeptide are used as nutrients, and Panax notoginseng, the nutrients, and sulfate are combined.

[0035] (2) A method for preparing the above-mentioned wound repair nutritional support agent is provided, wherein the raw materials are prepared according to weight parts, mixed, and the wound repair nutritional support agent is obtained. The preparation method is simple and easy to operate.

[0036] (3) Provide the use of nutrients and sulfates in enhancing the antibacterial effect of Panax notoginseng, wherein the nutrients are glutamine, branched-chain amino acids, arginine, β-hydroxy-β-methylbutyrate, whey protein powder, peptide raw materials, zinc, and casein phosphopeptide; the peptide raw materials are soy peptide powder or collagen peptide, and the sulfate is magnesium sulfate or copper sulfate; and the nutrients are mixed with Panax notoginseng according to the weight ratio of (1) to prepare a solid preparation. The present invention is the first to discover that nutrients and sulfates can enhance the antibacterial effect of Panax notoginseng, providing a new anti-infection solution.

[0037] Next, the effects of the present invention will be described through specific examples.

[0038] It should be noted that the glutamine used in the Examples of the present invention and the Reference Examples was purchased from Tongliao Meihua Biotechnology Co., Ltd., and the product name is L-glutamine; branched-chain amino acids were purchased from Xinjiang Fufeng Biotechnology Co., Ltd., and the product name is compound amino acids; arginine was purchased from Sichuan Huatang Jurui Biotechnology Co., Ltd., and the health number is 69430-36-0; β-hydroxy-β-methylbutyrate was purchased from β-hydroxy-β-methylbutyrate calcium from Jiyuan Group Co., Ltd.; whey protein powder was purchased from Germany--LVE0, and the main component is whey protein; zinc 0.2 was purchased from Beijing Jinkangpu Food Technology Co., Ltd. Shunyi Branch, and was added in the form of zinc sulfate, zinc gluconate, zinc acetate or zinc citrate, measured in parts by weight of zinc element; casein phosphopeptide was purchased from Shanxi Ruisi Biotechnology Co., Ltd., item number RS-0516-673; the peptide raw material is soy peptide powder, and soy peptide powder was purchased from Tianjin Buer Protein Co., Ltd.; collagen peptide was purchased from Xi'an Tianfeng Biotechnology Co., Ltd., and the extraction source is fish skin.

[0039] Example 1 A wound repair nutritional support agent is prepared from the following raw materials in parts by weight: 7 parts of glutamine, 5 parts of branched-chain amino acids, 10 parts of arginine, 0.3 parts of calcium β-hydroxy-β-methylbutyrate, 40 parts of whey protein powder, 5 parts of soy peptide powder, 0.2 parts of zinc, 6 parts of casein phosphopeptide, and 0.2 parts of Panax notoginseng. The Panax notoginseng is 100-mesh powder. Zinc is provided by zinc sulfate, and "0.2 parts of zinc" is calculated by weight of the zinc element.

[0040] Prepare various raw materials according to weight proportions, mix them, and obtain a wound repair nutritional support agent.

[0041] Example 2 A wound repair nutritional support agent is prepared from the following raw materials in parts by weight: 10 parts of glutamine, 15 parts of branched-chain amino acids, 15 parts of arginine, 0.6 parts of sodium β-hydroxy-β-methylbutyrate, 60 parts of whey protein powder, 8 parts of collagen peptides, 0.25 parts of zinc, 9 parts of casein phosphopeptide, and 0.2 parts of Panax notoginseng. The Panax notoginseng is Panax notoginseng powder with a particle size of 200 mesh. Zinc is provided by zinc gluconate, and "0.25 parts of zinc" is calculated by weight of the zinc element.

[0042] Prepare various raw materials according to weight proportions, mix them, and obtain a wound repair nutritional support agent.

[0043] Example 3 A wound repair nutritional support agent is prepared from the following raw materials in parts by weight: 7 parts of glutamine, 5 parts of branched-chain amino acids, 10 parts of arginine, 0.3 parts of calcium β-hydroxy-β-methylbutyrate, 40 parts of whey protein powder, 5 parts of soy peptide powder, 0.2 parts of zinc, 6 parts of casein phosphopeptide, and 0.3 parts of Panax notoginseng. The Panax notoginseng is 100-mesh powder. Zinc is provided by zinc sulfate, and "0.2 parts of zinc" is calculated by weight of the zinc element.

[0044] Prepare various raw materials according to weight proportions, mix them, and obtain a wound repair nutritional support agent.

[0045] Example 4 A wound repair nutritional support agent is prepared from the following raw materials in parts by weight: 7 parts of glutamine, 5 parts of branched-chain amino acids, 10 parts of arginine, 0.3 parts of calcium β-hydroxy-β-methylbutyrate, 40 parts of whey protein powder, 5 parts of soy peptide powder, 0.2 parts of zinc, 6 parts of casein phosphopeptide, and 0.4 parts of Panax notoginseng. The Panax notoginseng is 100-mesh powder. Zinc is provided by zinc sulfate, and "0.2 parts of zinc" is calculated by weight of the zinc element.

[0046] Prepare various raw materials according to weight proportions, mix them, and obtain a wound repair nutritional support agent.

[0047] Example 5 A wound repair nutritional support agent is prepared from the following raw materials in parts by weight: 7 parts of glutamine, 5 parts of branched-chain amino acids, 10 parts of arginine, 0.3 parts of calcium β-hydroxy-β-methylbutyrate, 40 parts of whey protein powder, 5 parts of soy peptide powder, 0.2 parts of zinc, 6 parts of casein phosphopeptide, and 0.5 parts of Panax notoginseng. The Panax notoginseng is 100-mesh powder. Zinc is provided by zinc sulfate, and "0.2 parts of zinc" is calculated by weight of the zinc element.

[0048] Prepare various raw materials according to the weight ratio, mix them, and obtain the wound repair nutritional support agent.

[0049] Example 6 A wound repair nutritional support agent is prepared from the following raw materials in parts by weight: 7 parts glutamine, 5 parts branched-chain amino acids, 10 parts arginine, 0.3 parts calcium β-hydroxy-β-methylbutyrate, 40 parts whey protein powder, 5 parts soy peptide powder, 0.2 parts zinc, 6 parts casein phosphopeptide, 0.2 parts Panax notoginseng, and 0.001 parts sulfate; the sulfate is magnesium sulfate. The Panax notoginseng powder is 100-mesh. Zinc is provided by zinc sulfate, and the "0.2 parts zinc" is calculated by weight of the zinc element.

[0050] Prepare various raw materials according to weight proportions, mix them, and obtain a wound repair nutritional support agent.

[0051] Example 7 A wound repair nutritional support agent is prepared from the following raw materials in parts by weight: 7 parts glutamine, 5 parts branched-chain amino acids, 10 parts arginine, 0.3 parts calcium β-hydroxy-β-methylbutyrate, 40 parts whey protein powder, 5 parts soy peptide powder, 0.2 parts zinc, 6 parts casein phosphopeptide, 0.2 parts Panax notoginseng, and 0.002 parts sulfate; the sulfate is magnesium sulfate. The Panax notoginseng is 100-mesh powder. Zinc is provided by zinc sulfate, and the "0.2 parts zinc" is calculated by weight of the zinc element.

[0052] Prepare various raw materials according to weight proportions, mix them, and obtain a wound repair nutritional support agent.

[0053] Example 8 A wound repair nutritional support agent is prepared from the following raw materials in parts by weight: 7 parts glutamine, 5 parts branched-chain amino acids, 10 parts arginine, 0.3 parts calcium β-hydroxy-β-methylbutyrate, 40 parts whey protein powder, 5 parts soy peptide powder, 0.2 parts zinc, 6 parts casein phosphopeptide, 0.2 parts Panax notoginseng, and 0.003 parts sulfate; the sulfate is magnesium sulfate. The Panax notoginseng is 100-mesh powder. Zinc is provided by zinc sulfate, and the "0.2 parts zinc" is calculated by weight of the zinc element.

[0054] Prepare various raw materials according to weight proportions, mix them, and obtain a wound repair nutritional support agent.

[0055] Example 9 A wound repair nutritional support agent is prepared from the following raw materials in parts by weight: 7 parts glutamine, 5 parts branched-chain amino acids, 10 parts arginine, 0.3 parts calcium β-hydroxy-β-methylbutyrate, 40 parts whey protein powder, 5 parts soy peptide powder, 0.2 parts zinc, 6 parts casein phosphopeptide, 0.2 parts Panax notoginseng, and 0.001 parts sulfate; the sulfate is copper sulfate. The Panax notoginseng is 100-mesh powder. Zinc is provided by zinc sulfate, and the "0.2 parts zinc" is calculated by weight of the zinc element.

[0056] Prepare various raw materials according to weight proportions, mix them, and obtain a wound repair nutritional support agent.

[0057] Example 10 A wound repair nutritional support agent is prepared from the following raw materials in parts by weight: 7 parts glutamine, 5 parts branched-chain amino acids, 10 parts arginine, 0.3 parts calcium β-hydroxy-β-methylbutyrate, 40 parts whey protein powder, 5 parts soy peptide powder, 0.2 parts zinc, 6 parts casein phosphopeptide, 0.2 parts Panax notoginseng, and 0.002 parts sulfate; the sulfate is copper sulfate. The Panax notoginseng is 100-mesh powder. Zinc is provided by zinc sulfate, and the "0.2 parts zinc" is calculated by weight of the zinc element.

[0058] Prepare various raw materials according to weight proportions, mix them, and obtain a wound repair nutritional support agent.

[0059] Example 11 A wound repair nutritional support agent is prepared from the following raw materials in parts by weight: 7 parts glutamine, 5 parts branched-chain amino acids, 10 parts arginine, 0.3 parts calcium β-hydroxy-β-methylbutyrate, 40 parts whey protein powder, 5 parts soy peptide powder, 0.2 parts zinc, 6 parts casein phosphopeptide, 0.2 parts Panax notoginseng, and 0.003 parts sulfate; the sulfate is copper sulfate. The Panax notoginseng is 100-mesh powder. Zinc is provided by zinc sulfate, and the "0.2 parts zinc" is calculated by weight of the zinc element.

[0060] Prepare various raw materials according to weight proportions, mix them, and obtain a wound repair nutritional support agent.

[0061] Comparative Example 1 A wound repair nutritional support agent, which is only Panax notoginseng. The Panax notoginseng is Panax notoginseng powder with a particle size of 100 meshes.

[0062] Comparative Example 2 A wound repair nutritional support agent is prepared from the following raw materials in parts by weight: 0.2 parts of Panax notoginseng and 0.001 parts of sulfate, wherein the sulfate is magnesium sulfate. The Panax notoginseng is Panax notoginseng powder with a particle size of 100 mesh.

[0063] Prepare various raw materials according to the weight ratio, mix them, and obtain the wound repair nutritional support agent.

[0064] Comparative Example 3 A wound repair nutritional support agent is prepared from the following raw materials in parts by weight: 0.2 parts of Panax notoginseng and 0.001 parts of sulfate, wherein the sulfate is copper sulfate. The Panax notoginseng is Panax notoginseng powder with a particle size of 100 mesh.

[0065] Prepare various raw materials according to the weight ratio, mix them, and obtain the wound repair nutritional support agent.

[0066] 1. The antibacterial experiment is as follows.

[0067] (1) Preparation of bacterial suspension Material preparation: Prepare fresh cultures of Staphylococcus aureus ATCC6538, Staphylococcus epidermidis ATCC12228, Pseudomonas aeruginosa CMCC(B)10104, and vancomycin-resistant Enterococci (VRE).

[0068] Prepare sterile water.

[0069] Staphylococcus aureus ATCC6538, Staphylococcus epidermidis ATCC12228, Pseudomonas aeruginosa CMCC(B)10104, and vancomycin-resistant Enterococci (VRE) were activated and the concentration of the bacterial suspension of each strain was adjusted to 1.0×10 5 cfu / mL.

[0070] (2) Operating environment: It is carried out in a clean bench, which provides a sterile environment. Detection process: The experimental group took a concentration of 1.0×10 5 cfu / mL of bacterial suspension was added to 5 mL of the liquid to be tested, which was a liquid with a concentration of 1 g / 100 mL prepared from any of the wound repair nutritional support agents in the examples and control examples, and allowed to react at room temperature at 25°C for 20 minutes. 5 The bacterial suspension containing 0.1 cfu / mL served as the blank control group, and all other procedures were the same as those for the experimental groups. The number of viable bacteria in each group was counted after treatment. The inhibition rate was calculated using the following formula.

[0071] 00% .

[0072] The antibacterial test results are shown in Table 1.

[0073] Table 1 Statistical results of antibacterial rate In Table 1, the difference between Example 1 and Example 2 is that the weight proportions of nutrients such as glutamine, branched-chain amino acids, arginine, β-hydroxy-β-methylbutyrate calcium, whey protein powder, soy peptide powder, zinc, and casein phosphopeptide are different. The difference between Example 3 and Example 1 is that the weight portion of Panax notoginseng is 0.3 parts, the difference between Example 4 and Example 1 is that the weight portion of Panax notoginseng is 0.4 parts, the difference between Example 5 and Example 1 is that the weight portion of Panax notoginseng is 0.5 parts, the difference between Example 6 and Example 1 is that 0.001 parts by weight of magnesium sulfate is further added, the difference between Example 7 and Example 1 is that 0.002 parts by weight of magnesium sulfate is further added, the difference between Example 8 and Example 1 is that 0.003 parts by weight of magnesium sulfate is further added, the difference between Example 9 and Example 1 is that 0.001 parts by weight of copper sulfate is further added, the difference between Example 10 and Example 1 is that 0.002 parts by weight of copper sulfate is further added, and the difference between Example 11 and Example 1 is that 0.003 parts by weight of copper sulfate is further added. What is compared between Control Example 1 and Example 1 is the effect of nutrients on the antibacterial effect of Panax notoginseng, what is compared between Control Example 2 and Control Example 1 is the effect of magnesium sulfate on the antibacterial effect of Panax notoginseng, and what is compared between Control Example 3 and Control Example 1 is the effect of copper sulfate on the antibacterial effect of Panax notoginseng.

[0074] The main conclusions from Table 1 are: Examples 1-11 have superior antibacterial effects compared to the control examples. Compared to Control Example 1, which used Panax notoginseng alone, the addition of nutrients such as glutamine, branched-chain amino acids, arginine, calcium β-hydroxy-β-methylbutyrate, whey protein powder, soy peptide powder, zinc, and casein phosphopeptide (Example 1) enhanced the antibacterial effect of Panax notoginseng. Adding copper sulfate (Control Example 2) or magnesium sulfate (Control Example 3) also enhanced the antibacterial effect of Panax notoginseng. Examples 6-11 achieved the best antibacterial effects when nutrients and sulfate were added simultaneously.

[0075] 2. Detailed explanation of the application effects of the nutrients involved in the present invention (1) Whey protein powder can supplement nutrition and reduce intestinal complications. For relevant experimental results, please refer to "Wang Ziqin, Liu Yanrong, Chen Yongchun, Yang Sheng. Study on the effect of early enteral nutritional support on the efficacy of stroke patients [J]. Parenteral and Enteral Nutrition (6): 335-337 [2025-05-16]. DOI: 10.3969 / j.issn.1007-810X.2011.06.005".

[0076] (2) Glutamine can improve the digestive tract condition of patients. For relevant experimental results, please refer to "Zhao Xiaorui, Zhou Qingan, Li Tongjing. Research on the application of early individualized enteral nutrition support therapy in critically ill stroke patients [J]. China Medical Guide, 2011, 9(31):2.DOI:10.3969 / j.issn.1671-8194.2011.31.273".

[0077] (3) Soy peptide powder is beneficial to restore intestinal function, replenish energy, and promote patient recovery. For relevant experimental results, please refer to "Huang Xiaoming, Du Zonghan, Lei Yan, et al. Application of early nutritional preparations and homemade homogenates in patients with severe craniocerebral injury [J]. Electronic Journal of Tumor Metabolism and Nutrition, 2021".

[0078] (4) Branched-chain amino acids help improve liver function and nutritional status. For relevant experimental results, please refer to "Xie Qi, Shu Xiaoliang, Xie Lixin. Clinical observation of the effect of high-branched-chain amino acid enteral nutrition on patients with postoperative liver dysfunction [J]. Parenteral and Enteral Nutrition, 2013, 020(002):75-77.DOI:10.3969 / j.issn.1007-810X.2013.02.004", "Yang Junhong, Tian Xi, Chen Yingxin, et al. Effect of enteral nutrition preparations for liver disease on protein metabolism and liver function in children with liver damage [J]. Journal of Practical Clinical Pediatrics, 2008, 23(19):3.DOI:10.3969 / j.issn.1003-515X.2008.19.016" and so on.

[0079] (5) β-Hydroxy-β-methylbutyrate can promote the growth of muscle cells, increase muscle mass, and help enhance the body's immune function.

[0080] (6) Zinc is an important component of the immune system, helping to enhance immunity, prevent and treat infections, help maintain skin health, promote wound healing, and also has antioxidant effects that can scavenge free radicals and protect cells from oxidative damage.

[0081] (7) Casein phosphopeptides can form soluble complexes with divalent mineral nutrients such as calcium, iron, and zinc, significantly improving the absorption rate of these minerals, contributing to bone calcification, enhancing the utilization of calcium in bones, and slowing down bone degeneration. The amino acids and peptides released after hydrolysis can enhance the hydration of the stratum corneum and repair the skin barrier function.

[0082] Since the above "Detailed Explanation of the Effects of the Nutrients Involved in the Present Invention" is based on prior research results that demonstrate the recovery effects of the relevant nutrient components and their nutritional support, the present invention continues to utilize the nutritional supplementation effects of these nutrients. The present invention focuses on innovative research on their anti-infection effects.

[0083] It should be noted that when numerical ranges are involved in the present invention, it should be understood that both endpoints of each numerical range and any value between the two endpoints can be selected. Since the steps and methods used are the same as those in the embodiments, in order to avoid redundancy, the present invention describes preferred embodiments. Although preferred embodiments of the present invention have been described, those skilled in the art may make additional changes and modifications to these embodiments once they understand the inventive concept of the present invention, and such changes and modifications fall within the scope of the present invention.

[0084] Obviously, those skilled in the art may make various changes and modifications to the present invention without departing from the spirit and scope of the present invention. If these modifications and variations of the present invention fall within the scope of the equivalent technology of the present invention, the present invention is intended to include these modifications and variations.

Claims

1. A wound repair nutritional support agent, characterized in that: Made from the following raw materials in parts by weight: 7 to 10 parts of glutamine, 5 to 15 parts of branched-chain amino acids, 10 to 15 parts of arginine, 0.3 to 0.6 parts of β-hydroxy-β-methylbutyrate, 40 to 60 parts of whey protein powder, 5 to 8 parts of peptide raw materials, 6 to 9 parts of casein phosphopeptide, 0.2 to 0.5 parts of Panax notoginseng, and 0 to 0.003 parts of sulfate; the peptide raw material is soy peptide powder or collagen peptide, and the sulfate is magnesium sulfate or copper sulfate.

2. The wound repair nutritional support agent according to claim 1, characterized in that The Panax notoginseng is Panax notoginseng powder with a particle size of 100 mesh to 200 mesh.

3. The wound repair nutritional support agent according to claim 1, characterized in that The β-hydroxy-β-methylbutyrate is calcium β-hydroxy-β-methylbutyrate or sodium β-hydroxy-β-methylbutyrate.

4. The preparation method of the wound repair nutritional support agent according to claim 1, characterized in that: Prepare various raw materials according to weight proportions, mix them, and obtain a wound repair nutritional support agent.

5. The use of the wound repair nutritional support agent according to claim 1, characterized in that: The application refers to the preparation of a preparation for providing nutritional support, promoting wound repair and inhibiting bacteria.

6. The use according to claim 5, characterized in that Provides nutritional support to enhance immunity and maintain gastrointestinal health.

7. The use according to claim 5, characterized in that The promotion of wound repair refers to shortening wound healing time and reducing scars.

8. The application of nutrients and sulfate in enhancing the antibacterial effect of Panax notoginseng is characterized in that: The nutrients are glutamine, branched-chain amino acids, arginine, β-hydroxy-β-methylbutyrate, whey protein powder, peptide raw materials, zinc and casein phosphopeptide; the peptide raw materials are soybean peptide powder or collagen peptide, and the sulfate is magnesium sulfate or copper sulfate; and the nutrients, sulfate and Panax notoginseng are mixed in proportions by weight according to claim 1 to prepare a solid preparation.

9. The use according to claim 8, characterized in that The weight portion of sulfate is 0.001 to 0.003 parts.

10. The use according to claim 7 or 8, characterized in that The antibacterial effect refers to the inhibitory effect on Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa and vancomycin-resistant enterococci.

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