Cleaning agent without skin irritation and method thereof

Abstract

The invention relates to the field of skin cleaning agents, and discloses a cleaning agent without skin irritation and a method thereof. The cleaning agent is prepared from the following raw materials in parts by weight: 8 to 12 parts of anionic surfactant, 5 to 8 parts of nonionic surfactant, 3 to 5 parts of zwitterionic surfactant, 2 to 4 parts of nano inorganic particles, 0.5 to 1.2 parts of skin barrier repairing agent, 2 to 3 parts of humectant, 0.1 to 0.3 part of lipid component, 3 to 5 parts of polyhydric alcohol, 0.5 to 1 part of antibacterial nanocapsule and 0.2 to 0.5 part of anti-inflammatory component. Sodium cocoyl glycinate, decyl glucoside and lauramidopropyl betaine are compounded to form a surfactant system, the surfactant system is highly matched with a natural weakly acidic protective film of the skin, dirt is removed through low-irritation surface tension adjustment during cleaning, the situation that a traditional alkaline cleaning agent damages a skin grease layer is avoided, and the problems that the skin is dry and sensitive after cleaning are solved.

Description

Technical Field

[0001] The present invention relates to the technical field of skin cleansing agents, in particular to a skin-free cleansing agent and a method thereof. Background Art

[0002] In the skin care sector, consumer demand for gentle cleansing products is growing. Traditional skin cleansers can damage the skin barrier due to irritating ingredients or unsuitable pH levels, leading to dryness, sensitivity, and other skin issues. Against this backdrop, the industry is focusing on developing skin cleansers that gently cleanse, protect the skin barrier, and offer antibacterial and anti-inflammatory benefits, aiming to meet the needs of people with different skin types for safe and effective cleansing products.

[0003] Skin cleansers in the existing technology often use alkaline surfactants or irritating chemical cleaning ingredients, whose pH value is quite different from the natural weakly acidic environment of the skin. During cleansing, they tend to excessively remove skin oils, destroy the skin barrier structure, and lead to a decrease in the skin's ability to retain moisture. After use, problems such as dryness, tightness, and even redness may occur, making it difficult to meet the needs of gentle cleansing. Summary of the Invention

[0004] In response to the deficiencies of the prior art, the present invention provides a skin-free cleanser and method thereof, which solves the problem that skin cleansers in the prior art often use alkaline surfactants or irritating chemical cleaning ingredients, whose pH value is significantly different from the natural weakly acidic environment of the skin, and are prone to excessive removal of skin oil during cleansing, making it difficult to meet the needs of gentle cleansing.

[0005] To achieve the above objectives, the present invention is implemented through the following technical solutions:

[0006] A skin-friendly cleaning agent comprising the following raw materials in parts by weight:

[0007] 8-12 parts of anionic surfactant, 5-8 parts of nonionic surfactant, 3-5 parts of zwitterionic surfactant, 2-4 parts of nano inorganic particles, 0.5-1.2 parts of skin barrier repair agent, 2-3 parts of moisturizer, 0.1-0.3 parts of lipid component, 3-5 parts of polyol, 0.5-1 part of antibacterial nanocapsule, 0.2-0.5 parts of anti-inflammatory component, 0.2-0.5 parts of plant extract, 0.1-0.5 parts of penetration enhancer, and 60-76 parts of solvent.

[0008] Preferably, the anionic surfactant is sodium cocoyl glycinate, and its pH value is 5.5-6.0;

[0009] The nonionic surfactant is decyl glucoside, and its biodegradability is ≥95%;

[0010] The zwitterionic surfactant is lauramidopropyl betaine.

[0011] Preferably, the nano inorganic particles are silicon dioxide with a particle size of 20-50 nm;

[0012] The skin barrier repair agent is ceramide NP with a purity of ≥98%.

[0013] Preferably, the antibacterial nanocapsules are tea tree oil nanocapsules with an encapsulation efficiency of ≥85%;

[0014] The anti-inflammatory component includes dipotassium glycyrrhizate, and the plant extract includes asiaticoside, and the mass ratio of the two is 1:1.

[0015] Preferably, the penetration enhancer is cyclopentasiloxane;

[0016] The solvent is deionized water, and the conductivity is ≤1 μS / cm.

[0017] Preferably, the present invention also provides a method for preparing a skin-free cleaning agent, comprising the following steps:

[0018] S1, pretreatment, using a high-pressure homogenizer to encapsulate the antimicrobial active ingredients into nanocapsules, and using a magnetic stirrer to surface activate the nano-inorganic particles;

[0019] S2, aqueous phase preparation, heating the solvent to 75 ° C in a sandwich reactor, adding anionic surfactant, nonionic surfactant, and zwitterionic surfactant in sequence through a propeller stirrer at 300 rpm, stirring and dissolving;

[0020] S3, oil phase preparation: melt the skin barrier repair agent, lipid component, and penetration enhancer in a melting tank to 60°C, add the activated nano inorganic particles, and homogenize at 5000 rpm for 5 minutes using a high-pressure homogenizer;

[0021] S4, emulsification, cooling the water phase to 45°C in an emulsification kettle, slowly adding the oil phase, and homogenizing and emulsifying the mixture at 10,000 rpm for 10 minutes using a high-pressure homogenizer to form an emulsion;

[0022] S5, functional addition, adding moisturizer, polyol, antibacterial nanocapsule, anti-inflammatory ingredient, and plant extract to the emulsion in a mixing tank, and mixing uniformly using a magnetic stirrer at 50 rpm;

[0023] S6. Post-treatment: adjust the system pH to 5.5-6.0 with 10% citric acid solution in a pH adjustment tank, degas in a vacuum degassing tank at a vacuum degree of -0.08MPa, and then fill with a filling machine.

[0024] Preferably, the homogenization pressure of the high-pressure homogenizer in step S1 is 50-80 MPa;

[0025] The activation treatment of the nano inorganic particles includes: soaking them in a 0.1M citric acid solution on a magnetic stirrer for 30-60 minutes.

[0026] Preferably, in the step S4, the temperature of the emulsification kettle is controlled at 44-46° C. during the emulsification process, and the homogenization pressure of the high-pressure homogenizer is 15-20 MPa.

[0027] Preferably, in step S5, the ambient humidity of the mixing tank is ≤40%, and the temperature fluctuation of the magnetic stirrer is ≤±2°C.

[0028] Preferably, the vacuum degree of the vacuum degassing tank in step S6 is -0.08 MPa.

[0029] The present invention provides a skin-free cleaning agent and a method thereof. The invention has the following beneficial effects:

[0030] 1. The present invention adopts a surfactant system composed of sodium cocoyl glycinate, decyl glucoside and lauramidopropyl betaine, which is highly compatible with the skin's natural weakly acidic protective film. During cleaning, it removes dirt through low-irritation surface tension adjustment, avoids traditional alkaline detergents from damaging the skin's oil layer, and reduces problems such as dryness and sensitivity of the skin after cleaning.

[0031] 2. The present invention adds ceramide NP and phytosphingosine with a purity of ≥98% to the formula. The two can directly replenish the missing lipid components of the stratum corneum, simulate the natural barrier structure of the skin, repair the lipid arrangement between damaged stratum corneum cells, enhance the skin's water-locking ability, reduce the amount of water loss through the epidermis, thereby improving the skin's tolerance to external stimuli and improving problems such as dryness and desquamation caused by incomplete barrier function.

[0032] 3. The tea tree oil nanocapsules in the present invention slowly release antibacterial active ingredients through nanocarriers, continuously inhibiting the reproduction of pathogenic bacteria such as Staphylococcus aureus, and reducing the risk of inflammation from the source; at the same time, dipotassium glycyrrhizate and asiaticoside act synergistically in a 1:1 mass ratio. The former inhibits histamine release and the activity of inflammatory factors, while the latter promotes collagen synthesis and enhances vascular elasticity, quickly alleviating acute inflammatory reactions such as skin redness and burning, achieving dual antibacterial and anti-inflammatory effects.

[0033] 4. This invention replaces traditional petroleum-based ingredients with green surfactants such as decyl glucoside, which have a biodegradability of ≥95%. Its molecular structure can be decomposed into carbon dioxide and water by microorganisms in the natural environment, reducing pollution to water bodies and soil. It is used with high-purity deionized water with a conductivity of ≤1μS / cm as a solvent to prevent impurity ions from affecting the stability of the ingredients, ensuring that the product is safe and non-irritating and meets environmental standards.

[0034] 5. During the preparation process of the present invention, the nano-silica particles are surface activated by a high-pressure homogenizer to fully expose their hydroxyl groups, enhance their adsorption capacity with surfactants, and improve the dirt capture efficiency during cleaning. The oil phase preparation and emulsification steps use high-pressure homogenization technology to shear the oil phase into nano-scale droplets, ensuring that active ingredients such as ceramide NP are evenly dispersed to form a stable water-in-oil emulsion, thereby improving the product's skin feel and ingredient penetration efficiency, and ultimately achieving synergistic optimization of mildness, efficacy, and stability. BRIEF DESCRIPTION OF THE DRAWINGS

[0035] Figure 1 The present invention is a flow chart of a method for preparing a skin-free cleaning agent. DETAILED DESCRIPTION

[0036] The following will clearly and completely describe the technical solution of the present invention in conjunction with the accompanying drawings. Obviously, the embodiments described are only some embodiments of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0037] Please see the attached Figure 1 The embodiment of the present invention provides a skin-free cleaning agent, comprising the following raw materials in parts by weight:

[0038] 8-12 parts of anionic surfactant, 5-8 parts of nonionic surfactant, 3-5 parts of zwitterionic surfactant, 2-4 parts of nano inorganic particles, 0.5-1.2 parts of skin barrier repair agent, 2-3 parts of moisturizer, 0.1-0.3 parts of lipid component, 3-5 parts of polyol, 0.5-1 part of antibacterial nanocapsule, 0.2-0.5 parts of anti-inflammatory component, 0.2-0.5 parts of plant extract, 0.1-0.5 parts of penetration enhancer, and 60-76 parts of solvent.

[0039] The anionic surfactant is sodium cocoyl glycinate, with a pH of 5.5-6.0;

[0040] The non-ionic surfactant is decyl glucoside, with a biodegradability of ≥95%;

[0041] The zwitterionic surfactant is lauramidopropyl betaine.

[0042] The nano inorganic particles are silicon dioxide with a particle size of 20-50 nm;

[0043] The skin barrier repair agent is ceramide NP with a purity of ≥98%.

[0044] The antibacterial nanocapsules are tea tree oil nanocapsules with an encapsulation rate of ≥85%;

[0045] The anti-inflammatory ingredients include dipotassium glycyrrhizate, and the plant extracts include asiatica sideroside, and the mass ratio of the two is 1:1.

[0046] The penetration enhancer is cyclopentasiloxane;

[0047] The solvent is deionized water with a conductivity of ≤1μS / cm.

[0048] Specifically, anionic surfactant (sodium cocoyl glycinate, 8-12 parts): as the main cleansing ingredient, its pH value is 5.5-6.0, which is highly compatible with the weakly acidic environment of the skin. It can gently reduce surface tension and remove dirt, while avoiding the loss of skin oil caused by excessive cleansing, and has both cleaning power and mildness.

[0049] Non-ionic surfactant (decyl glucoside, 5-8 parts): compounded with anionic surfactant, biodegradability ≥ 95%, low irritation and high foam stability, can enhance the compatibility of the cleaning system, synergistically improve the decontamination effect, while reducing damage to the skin barrier, meeting environmental protection requirements.

[0050] Zwitterionic surfactant (lauramidopropyl betaine, 3-5 parts): It can exist stably in both acidic and alkaline environments, can adjust the fineness of the system's foam, enhance the mildness of the cleaning ingredients, reduce the irritation of a single surfactant, and has certain antibacterial and skin softening effects.

[0051] Nano inorganic particles (silicon dioxide with a particle size of 20-50nm, 2-4 parts): Through the characteristics of nano-scale particle size (20-50nm), they can accurately absorb dirt and oil on the skin surface. Their porous structure can enhance the adsorption capacity of the cleansing system, while physically assisting in the removal of dead skin without clogging pores, thereby improving cleaning efficiency.

[0052] Skin barrier repair agent (ceramide NP with purity ≥98%, 0.5-1.2 parts): As the core component of the skin's stratum corneum lipids, ceramide NP with purity ≥98% can directly replenish the missing lipids in the skin barrier, repair the damaged stratum corneum, enhance the skin's ability to lock in moisture, reduce water loss, and improve the skin's tolerance to irritation.

[0053] Moisturizers (panthenol, etc., 2-3 parts): By absorbing environmental moisture and locking moisture in the skin's stratum corneum, it maintains the skin's hydration. It works synergistically with ceramide NP to further enhance the moisturizing effect and relieve dry skin after cleansing.

[0054] Lipid components (such as phytosphingosine, 0.1-0.3 parts): together with ceramide NP, they constitute the lipid structure of the skin barrier, regulate lipid fluidity, and enhance the barrier function. They are especially suitable for skin with damaged barriers and can improve problems such as rough skin and desquamation.

[0055] Polyols (1,2-pentanediol, etc., 3-5 parts): They have both moisturizing and antiseptic properties. By adjusting the viscosity and osmotic pressure of the system, they enhance the penetration effect of the moisturizer, inhibit the growth of microorganisms, improve product stability, and reduce the use of chemical preservatives.

[0056] Antibacterial nanocapsules (tea tree oil nanocapsules with an encapsulation rate ≥85%, 0.5-1 portion): Tea tree oil is encapsulated using nanocapsule technology, and an encapsulation rate ≥85% can achieve the slow release of antibacterial ingredients, long-term inhibition of pathogens such as Staphylococcus aureus, reduce the risk of skin inflammation, and avoid irritation from direct contact with the skin.

[0057] Anti-inflammatory ingredient (dipotassium glycyrrhizate, 0.2-0.5 parts): has hormone-like anti-inflammatory effects, can inhibit the release of histamine and the activity of inflammatory factors, quickly relieve sensitive symptoms such as skin redness and burning, and work synergistically with Centella asiatica to enhance the anti-inflammatory and repair effects.

[0058] Plant extract (asiaticoside, 0.2-0.5 parts): This active ingredient extracted from Centella asiatica can promote collagen synthesis and accelerate skin damage repair, while enhancing blood vessel wall elasticity and reducing post-inflammatory pigmentation. It is compounded with dipotassium glycyrrhizate in a 1:1 mass ratio to synergistically exert anti-inflammatory and soothing effects.

[0059] Penetration enhancer (cyclopentasiloxane, 0.1-0.5 parts): As a small molecule silicone compound, it can reduce the barrier resistance of the skin's stratum corneum, promote the penetration of effective ingredients such as ceramide NP and tea tree oil into the deep layers of the skin, improve the utilization rate of active ingredients, and enhance the overall efficacy of the product.

[0060] Solvent (deionized water, conductivity ≤1μS / cm, 60-76 parts): As the system matrix, high-purity deionized water with a conductivity of ≤1μS / cm can prevent impurity ions from affecting the stability of ingredients, dissolve water-soluble ingredients such as surfactants and humectants, and adjust the system consistency to ensure uniform dispersion of all ingredients.

[0061] This embodiment also provides a method for preparing a skin-free cleaning agent, comprising the following steps:

[0062] S1, pretreatment, using a high-pressure homogenizer to encapsulate the antimicrobial active ingredients into nanocapsules, and using a magnetic stirrer to surface activate the nano-inorganic particles;

[0063] S2, aqueous phase preparation, heating the solvent to 75 ° C in a sandwich reactor, adding anionic surfactant, nonionic surfactant, and zwitterionic surfactant in sequence through a propeller stirrer at 300 rpm, stirring and dissolving;

[0064] S3, oil phase preparation: melt the skin barrier repair agent, lipid component, and penetration enhancer in a melting tank to 60°C, add the activated nano inorganic particles, and homogenize at 5000 rpm for 5 minutes using a high-pressure homogenizer;

[0065] S4, emulsification, cooling the water phase to 45°C in an emulsification kettle, slowly adding the oil phase, and homogenizing and emulsifying the mixture at 10,000 rpm for 10 minutes using a high-pressure homogenizer to form an emulsion;

[0066] S5, functional addition, adding moisturizer, polyol, antibacterial nanocapsule, anti-inflammatory ingredient, and plant extract to the emulsion in a mixing tank, and mixing uniformly using a magnetic stirrer at 50 rpm;

[0067] S6. Post-treatment: adjust the system pH to 5.5-6.0 with 10% citric acid solution in a pH adjustment tank, degas in a vacuum degassing tank at a vacuum degree of -0.08MPa, and then fill with a filling machine.

[0068] The homogenization pressure of the high-pressure homogenizer in step S1 is 50-80 MPa;

[0069] The activation treatment of the nano-inorganic particles includes soaking them in a 0.1 M citric acid solution on a magnetic stirrer for 30-60 minutes.

[0070] In step S4, during the emulsification process, the temperature of the emulsification kettle is controlled at 44-46° C., and the homogenization pressure of the high-pressure homogenizer is 15-20 MPa.

[0071] In step S5, the ambient humidity of the mixing tank is ≤40%, and the temperature fluctuation of the magnetic stirrer is ≤±2°C.

[0072] The vacuum degree of the vacuum degassing tank in step S6 is -0.08 MP.

[0073] Specifically, in the S1 pretreatment step, a high-pressure homogenizer is used to encapsulate the antibacterial active ingredients into nanocapsules with an encapsulation rate of ≥85% under a pressure of 50-80MPa. Nano-scale encapsulation prevents the antibacterial ingredients from directly irritating the skin, while achieving slow release to prolong the antibacterial effect. A magnetic stirrer is used to soak 20-50nm nano-silica particles in 0.1M citric acid solution for 30-60 minutes. The acidic environment removes impurities on the particle surface and activates the hydroxyl groups, thereby enhancing its adsorption capacity with surfactants and ensuring more efficient dirt adsorption during cleaning.

[0074] In the S2 aqueous phase preparation step, deionized water with a conductivity of ≤1μS / cm is heated to 75°C in a sandwich reactor. Sodium cocoyl glycinate, decyl glucoside, and lauroyl amide propyl betaine are added sequentially at 300 rpm using a propeller stirrer. The optimal temperature promotes the full dissolution of the surfactants, forming a uniform, transparent aqueous phase. The three surfactants are combined to form a stable micellar structure, synergistically enhancing cleansing ability while reducing the irritation of each individual ingredient, resulting in a post-cleansing skin moisture loss rate of ≤10%.

[0075] In the S3 oil phase preparation step, ceramide NPs, phytosphingosine, and cyclopentasiloxane are heated to 60°C in a melting tank to form a homogenous oil phase. Activated nanosilica particles are then added and homogenized in a high-pressure homogenizer at 5000 rpm for 5 minutes to evenly disperse the inorganic particles. Low-temperature melting prevents oxidative inactivation of lipid components, ensuring the integrity of the barrier repair function. Homogenization enhances the oil phase's ability to absorb greasy dirt, paving the way for subsequent emulsification.

[0076] In the S4 emulsification step, the aqueous phase is cooled to 45°C before the oil phase is slowly added. Homogenization and emulsification are carried out in an emulsifier at 10,000 rpm and a pressure of 15-20 MPa for 10 minutes, with the temperature controlled at 44-46°C to form a stable oil-in-water emulsion. High-pressure homogenization shears the oil phase into nano-sized droplets (particle size ≤ 200 nm), enhancing the application feel while increasing the contact area between the active ingredients and the skin. Lipid components such as ceramide NPs are evenly distributed throughout the emulsion, replenishing the skin's stratum corneum during cleansing and enhancing the barrier repair effect.

[0077] In the S5 functional addition step, panthenol, 1,2-pentanediol, antimicrobial nanocapsules, dipotassium glycyrrhizate, and asiaticoside are added to the emulsion at a low speed (50 rpm) in a mixing tank maintained at an ambient humidity of ≤40%, with a temperature fluctuation of ≤±2°C. This low-temperature, low-speed mixing method minimizes damage to the antimicrobial capsule structure and the activity of the anti-inflammatory ingredients, ensuring that the tea tree oil achieves an 88%-95% antibacterial effect and that dipotassium glycyrrhizate and asiaticoside have a synergistic anti-inflammatory effect (redness reduction of 50%-75%). Furthermore, the low humidity environment maintains system stability and prevents moisture absorption and mildew.

[0078] In the S6 post-processing step, 10% citric acid solution is used to adjust the system pH to 5.5-6.0 to match the weakly acidic environment of the skin to inhibit bacterial growth and improve mildness; emulsified bubbles are removed through degassing at a vacuum degree of -0.08MPa to avoid foam stratification after filling and ensure that the product texture is fine and uniform; final aseptic filling ensures hygiene and safety. The prepared cleaning agent has an adapted pH and a stable emulsion, and has both efficient cleaning and gentle skin care effects.

[0079] The following is an introduction with reference to specific embodiments:

[0080] Example 1

[0081] Raw material ratio (parts by weight):

[0082] 10 parts of anionic surfactant (sodium cocoyl glycinate), 6 parts of nonionic surfactant (decyl glucoside), 4 parts of zwitterionic surfactant (lauramidopropyl betaine), 3 parts of nano-inorganic particles (silicon dioxide with a particle size of 30 nm), 0.8 parts of skin barrier repair agent (ceramide NP with a purity of 98%), 2.5 parts of moisturizer (panthenol), 0.2 parts of lipid component (phytosphingosine), 4 parts of polyol (1,2-pentanediol), 0.8 parts of antibacterial nanocapsules (tea tree oil nanocapsules with an encapsulation rate of 85%), 0.3 parts of anti-inflammatory ingredient (dipotassium glycyrrhizate), 0.3 parts of plant extract (asiaticoside), 0.3 parts of penetration enhancer (cyclopentasiloxane), and solvent (deionized water) are added to 100 parts.

[0083] Preparation steps:

[0084] S1. Pretreatment: Using a high-pressure homogenizer, 0.8 parts of tea tree oil were encapsulated into nanocapsules at a homogenization pressure of 60 MPa; using a magnetic stirrer, 3 parts of nano-silica particles were placed in a 0.1 mol / L citric acid solution and immersed for 45 minutes for surface activation.

[0085] S2. Prepare the aqueous phase by heating deionized water to 75°C in a sandwich reactor, and sequentially add 10 parts of sodium cocoyl glycinate, 6 parts of decyl glucoside, and 4 parts of lauroyl propyl betaine using a propeller stirrer at 300 rpm and stir to dissolve.

[0086] S3. Preparation of the oil phase: 0.8 parts of ceramide NP, 0.2 parts of phytosphingosine, and 0.3 parts of cyclopentasiloxane were melted to 60° C. in a melting tank, and 3 parts of activated nanosilica particles were added. The mixture was homogenized at 5000 rpm for 5 minutes using a stirrer.

[0087] S4. Emulsification: Cool the water phase to 45°C in an emulsification kettle and slowly add the oil phase. During the emulsification process, the temperature of the emulsification kettle is controlled at 45°C. Homogenize and emulsify the mixture for 10 minutes using a high-pressure homogenizer (homogenizing pressure 18 MPa, speed 10,000 rpm) to form an emulsion.

[0088] S5. Functional addition: In a mixing tank with an ambient humidity of 35% and a temperature fluctuation of ±1°C, 2.5 parts of panthenol, 4 parts of 1,2-pentanediol, 0.8 parts of tea tree oil nanocapsules, 0.3 parts of dipotassium glycyrrhizate, and 0.3 parts of asiaticoside were added to the emulsion and mixed evenly using a magnetic stirrer at 50 rpm.

[0089] S6. Post-treatment: adjust the system pH to 5.8 with 10% citric acid solution in a pH adjustment tank, degas in a vacuum degassing tank at -0.08 MPa for 25 minutes, and then fill with a filling machine.

[0090] Example 2

[0091] Raw material ratio (parts by weight):

[0092] 8 parts of anionic surfactant (sodium cocoyl glycinate), 5 parts of nonionic surfactant (decyl glucoside), 3 parts of zwitterionic surfactant (lauramidopropyl betaine), 2 parts of nano-inorganic particles (silicon dioxide with a particle size of 20 nm), 0.5 parts of skin barrier repair agent (ceramide NP with a purity of 98%), 2 parts of moisturizer (panthenol), 0.1 parts of lipid component (phytosphingosine), 3 parts of polyol (1,2-pentanediol), 0.5 parts of antibacterial nanocapsules (tea tree oil nanocapsules with an encapsulation rate of 85%), 0.2 parts of anti-inflammatory ingredient (dipotassium glycyrrhizate), 0.2 parts of plant extract (asiaticoside), 0.1 parts of penetration enhancer (cyclopentasiloxane), and solvent (deionized water) are added to 100 parts.

[0093] Preparation steps:

[0094] S1. Pretreatment: Using a high-pressure homogenizer, 0.5 parts of tea tree oil were encapsulated into nanocapsules at a homogenization pressure of 60 MPa; using a magnetic stirrer, 2 parts of nano-silica particles were placed in a 0.1 mol / L citric acid solution and immersed for 45 minutes for surface activation.

[0095] S2. Prepare the aqueous phase by heating deionized water to 75°C in a sandwich reactor, and sequentially add 8 parts of sodium cocoyl glycinate, 5 parts of decyl glucoside, and 3 parts of lauroyl propyl betaine using a propeller stirrer at 300 rpm and stir to dissolve.

[0096] S3. Preparation of the oil phase: 0.5 parts of ceramide NP, 0.1 parts of phytosphingosine, and 0.1 parts of cyclopentasiloxane were melted to 60° C. in a melting tank, and 2 parts of activated nano-silica particles were added. The mixture was homogenized at 5000 rpm with a stirrer for 5 minutes.

[0097] S4. Emulsification: Cool the water phase to 45°C in an emulsification kettle and slowly add the oil phase. During the emulsification process, the temperature of the emulsification kettle is controlled at 45°C. Homogenize and emulsify the mixture for 10 minutes using a high-pressure homogenizer (homogenizing pressure 18 MPa, speed 10,000 rpm) to form an emulsion.

[0098] S5. Functional addition: In a mixing tank with an ambient humidity of 35% and a temperature fluctuation of ±1°C, add 2 parts of panthenol, 3 parts of 1,2-pentanediol, 0.5 parts of tea tree oil nanocapsules, 0.2 parts of dipotassium glycyrrhizate, and 0.2 parts of asiaticoside to the emulsion and mix thoroughly using a magnetic stirrer at 50 rpm.

[0099] S6. Post-treatment: adjust the system pH to 5.8 with 10% citric acid solution in a pH adjustment tank, degas in a vacuum degassing tank at -0.08 MPa for 25 minutes, and then fill with a filling machine.

[0100] Example 3

[0101] Raw material ratio (parts by weight):

[0102] 12 parts of anionic surfactant (sodium cocoyl glycinate), 8 parts of nonionic surfactant (decyl glucoside), 5 parts of zwitterionic surfactant (lauramidopropyl betaine), 4 parts of nano-inorganic particles (silicon dioxide with a particle size of 50 nm), 1.2 parts of skin barrier repair agent (ceramide NP with a purity of 98%), 3 parts of moisturizer (panthenol), 0.3 parts of lipid component (phytosphingosine), 5 parts of polyol (1,2-pentanediol), 1 part of antibacterial nanocapsules (tea tree oil nanocapsules with an encapsulation rate of 85%), 0.5 parts of anti-inflammatory ingredient (dipotassium glycyrrhizate), 0.5 parts of plant extract (asiaticoside), 0.5 parts of penetration enhancer (cyclopentasiloxane), and solvent (deionized water) are added to 100 parts.

[0103] Preparation steps:

[0104] S1. Pretreatment: Using a high-pressure homogenizer, encapsulate 1 part of tea tree oil into nanocapsules at a homogenization pressure of 60 MPa; using a magnetic stirrer, place 4 parts of nano-silica particles in 0.1 mol / L citric acid solution for 45 minutes for surface activation.

[0105] S2. Prepare the aqueous phase by heating deionized water to 75°C in a sandwich reactor, and sequentially add 12 parts of sodium cocoyl glycinate, 8 parts of decyl glucoside, and 5 parts of lauroyl propyl betaine using a propeller stirrer at 300 rpm and stir to dissolve.

[0106] S3. Preparation of the oil phase: 1.2 parts of ceramide NP, 0.3 parts of phytosphingosine, and 0.5 parts of cyclopentasiloxane were melted to 60° C. in a melting tank, and 4 parts of activated nanosilica particles were added. The mixture was homogenized at 5000 rpm with a stirrer for 5 minutes.

[0107] S4. Emulsification: Cool the water phase to 45°C in an emulsification kettle and slowly add the oil phase. During the emulsification process, the temperature of the emulsification kettle is controlled at 45°C. Homogenize and emulsify the mixture for 10 minutes using a high-pressure homogenizer (homogenizing pressure 18 MPa, speed 10,000 rpm) to form an emulsion.

[0108] S5. Functional addition: In a mixing tank with an ambient humidity of 35% and a temperature fluctuation of ±1°C, 3 parts of panthenol, 5 parts of 1,2-pentanediol, 1 part of tea tree oil nanocapsules, 0.5 parts of dipotassium glycyrrhizate, and 0.5 parts of asiaticoside were added to the emulsion and mixed evenly using a magnetic stirrer at 50 rpm.

[0109] S6. Post-treatment: adjust the system pH to 5.8 with 10% citric acid solution in a pH adjustment tank, degas in a vacuum degassing tank at -0.08 MPa for 25 minutes, and then fill with a filling machine.

[0110] Table 1: Comparison table of differences among embodiments.

[0111] Comparison Dimension Example 1 Example 2 Example 3 Total amount of core raw materials 10 parts anion, 6 parts nonion, 4 parts zwitterion 8 parts anion, 5 parts nonionic, 3 parts zwitterionic 12 parts anion, 8 parts nonion, 5 parts zwitterion Nanosilica 3 parts, particle size 30nm 2 parts, particle size 20nm 4 parts, particle size 50nm Ceramide NP 0.8 parts, purity 98% 0.5 parts, purity 98% 1.2 parts, purity 98% Tea tree oil nanocapsules 0.8 portion, encapsulation rate 85% 0.5 portion, encapsulation rate 85% 1 serving, encapsulation rate 85% Dipotassium Glycyrrhizate / Asiaticoside 0.3 parts each, mass ratio 1:1 0.2 parts each, mass ratio 1:1 0.5 parts each, mass ratio 1:1 High pressure homogenization parameters (pretreatment) Pressure 60MPa, encapsulating 0.8 parts of tea tree oil Pressure 60MPa, encapsulating 0.5 parts of tea tree oil Pressure 60MPa, encapsulating 1 part of tea tree oil Emulsification temperature / pressure 45°C, 18 MPa, speed 10,000 rpm 45°C, 18 MPa, speed 10,000 rpm 45°C, 18 MPa, speed 10,000 rpm

[0112] Comparative Example:

[0113] Comparative Example 1 (without skin barrier repair agent)

[0114] Differences from Example 1: 1 / 4 ceramide NP and 1 / 4 phytosphingosine were omitted from the raw materials. All other ingredients and weights were the same as in Example 1. The preparation steps remained unchanged. This comparative example was used to verify the effectiveness of the skin barrier repair agent in improving skin tolerance and moisture retention. Comparative Example 2 (without antibacterial and anti-inflammatory ingredients) differs from Example 1: 1 / 4 tea tree oil nanocapsules, 1 / 4 dipotassium glycyrrhizate, and 1 / 4 asiaticoside were omitted from the raw materials. All other ingredients and weights were the same as in Example 1. The preparation steps remained unchanged. This comparative example was used to verify the effectiveness of the antibacterial and anti-inflammatory ingredients in alleviating skin sensitivity and inhibiting bacteria.

[0115] Comparative Example 3 (Traditional Surfactant Formula) differs from Example 1 by replacing 1 part sodium cocoyl glycinate, 1 part decyl glucoside, and 1 part lauramidopropyl betaine with an equal amount of sodium lauryl sulfate (SLS). All other ingredients and weights are the same as in Example 1. The preparation steps remain unchanged. This comparative example is used to compare the cleansing mildness of a mild surfactant with that of a traditional, harsh surfactant.

[0116] Comparative Example 4 (unactivated nano-inorganic particles)

[0117] Differences from Example 1: In the S1 pretreatment step, 0.1 M citric acid solution was not used to surface activate the nano-silica; untreated nanoparticles were added directly. Other components and preparation steps were the same as in Example 1. This comparative example was used to verify the effect of nanoparticle surface activation on cleaning efficiency and adsorption capacity.

[0118] Comparative Example 5 (Ordinary stirring emulsification)

[0119] Differences from Example 1: In the S4 emulsification step, a high-pressure homogenizer was not used. Instead, a conventional propeller stirrer was used at 500 rpm for 10 minutes for emulsification. All other ingredients and preparation steps were the same as in Example 1. This comparative example was used to verify the critical role of high-pressure homogenization in emulsion stability and active ingredient distribution.

[0120] Table 2: Comparative effect table of embodiments, comparative examples and prior art.

[0121] Comparison Project Example 1 Example 2 Example 3 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 pH 5.8 5.7 5.9 5.8 5.8 8.2 5.8 5.8 Skin moisture loss rate after cleansing 8 10 7 18 15 25 15 12 Skin barrier repair ability 40 30 50 5 35 -20 30 25 Antibacterial effect 92 88 95 0 0 0 88 85 Anti-inflammatory effect 65 50 75 10 5 -15 60 50 Biodegradability 95 95 95 95 95 60 95 95

[0122] Comparison project explanation:

[0123] The pH value indicates the acidity or alkalinity of the cleanser solution. A pH of 7 is neutral, below 7 is acidic, and above 7 is alkaline. The normal pH value on the skin surface is approximately 5.5-6.5 (weakly acidic). Cleansers close to this range are less damaging to the skin barrier.

[0124] Detection method: Use a precision pH meter to measure the pH value of the solution and take the average value of three measurements.

[0125] Grading standards and significance:

[0126] 5.5-6.5: Matches the skin's natural acid-base environment, is mild and non-irritating, and is not easy to damage the skin barrier.

[0127] >7.0: Alkaline, which will excessively remove skin oil, disrupt the acid-base balance, and cause dry and sensitive skin.

[0128] Post-cleansing water loss (%): The percentage increase in transepidermal water loss (TEWL) after cleansing reflects the degree of skin barrier damage. The lower the water loss rate, the stronger the cleanser's ability to protect the skin barrier.

[0129] Testing method: Use a skin barrier function tester to measure the skin TEWL value before and 30 minutes after cleansing, and calculate the loss rate: subtract the TEWL value before cleansing from the TEWL value after cleansing, and then divide it by the value before cleansing to get the percentage of moisture loss.

[0130] Grading standards and significance:

[0131] <10%: Minimal moisture loss, skin barrier is barely damaged, suitable for long-term use on sensitive skin.

[0132] 10%-20%: Moisture loss is low, but the lack of barrier repair ingredients may lead to cumulative damage with long-term use.

[0133] >20%: Significant moisture loss, severe damage to the skin barrier, prone to dryness, redness and other problems.

[0134] Skin barrier repair ability (% reduction in water loss): After using the cleanser, the skin's water loss within 72 hours is reduced compared to the ratio before use, reflecting the product's ability to repair damaged skin barriers.

[0135] Testing method: Use a patch test to simulate skin barrier damage (such as stimulation with sodium lauryl sulfate). Measure the TEWL value for three consecutive days after using a cleanser and calculate the repair rate: subtract the TEWL value after repair from the TEWL value after damage, and then divide the result by the TEWL value after damage to obtain the percentage of reduced water loss.

[0136] Grading standards and significance:

[0137] ≥30%: Contains repair ingredients such as ceramide NP, which can effectively enhance the skin barrier function and relieve dryness and sensitivity.

[0138] <10%: Lack of repair ingredients and unable to improve barrier function.

[0139] Negative values: Increases water loss and further damages the barrier.

[0140] Antibacterial effect (inhibition rate %): The ability of the cleaning agent to inhibit Staphylococcus aureus. The higher the inhibition rate, the less bacteria can be grown on the skin surface and the lower the risk of inflammation.

[0141] Detection method: Agar diffusion method (inhibition zone test) is used. The cleaning solution is added dropwise to the bacterial culture medium. After 24 hours of incubation, the diameter of the inhibition zone is measured and the inhibition rate is calculated: the percentage of the inhibition zone area to the total area of ​​the culture medium inoculated with bacteria is the inhibition rate.

[0142] Grading standards and significance:

[0143] ≥85%: Tea tree oil nanocapsules exert antibacterial activity, effectively inhibiting bacterial growth and suitable for acne-prone or inflammatory skin.

[0144] 0%: No antibacterial effect, unable to prevent bacterial infection during the cleaning process.

[0145] 60% (the existing technology contains chemical antibacterial agents): Although they have antibacterial effects, chemical antibacterial agents (such as triclosan) are highly irritating and can easily cause contact dermatitis.

[0146] Anti-inflammatory effect (% reduction in redness): Using a simulated skin inflammation model (e.g., redness caused by UV radiation), the reduction in redness within 24 hours after using the cleanser reflects the product's ability to relieve inflammation.

[0147] Testing method: The change in the area of ​​redness is measured using a skin tester, and the reduction rate is calculated as follows: the initial redness area minus the area after 24 hours, divided by the initial area, to obtain the percentage of redness reduction.

[0148] Grading standards and significance:

[0149] ≥50%: Dipotassium glycyrrhizate and asiaticaside work synergistically to fight inflammation, quickly relieving skin redness, burning and other discomforts.

[0150] <10%: Lacks anti-inflammatory ingredients and cannot improve inflammatory response.

[0151] Negative value: Strong irritants may increase inflammation and cause the redness to expand.

[0152] Biodegradability (%): The proportion of organic components in a cleaning agent that are decomposed by microorganisms in the natural environment, reflecting the environmental friendliness of the product.

[0153] Detection method: Using the OECD301B standard, culture under aerobic conditions for 28 days, measure the amount of carbon dioxide released and calculate the degradation rate.

[0154] Grading standards and significance:

[0155] ≥95%: Contains easily degradable surfactants such as decyl glucoside, which is environmentally friendly.

[0156] 40%-60%: Contains petroleum-based surfactants (sodium lauryl sulfate), which are difficult to degrade and may pollute water bodies.

[0157] Example and comparative example effect discussion:

[0158] Mild cleansing effect: Examples 1-3 all use a compound system of sodium cocoyl glycinate (pH 5.5-6.0), decyl glucoside (biodegradability ≥ 95%), and lauramidopropyl betaine. The pH value is controlled at 5.7-5.9 (Table 2), which is highly compatible with the skin's natural weakly acidic environment (pH 5.5-6.5). The skin's moisture loss rate after cleansing is only 7%-10% (well below the damage threshold of 20%), indicating that it can effectively cleanse without damaging the skin barrier.

[0159] Although Comparative Examples 1-2 maintain a weakly acidic pH, Comparative Example 1 lacks barrier repair ingredients such as ceramide NP. Long-term use may lead to a decline in barrier function due to accumulated water loss (loss rate of 18%); although Comparative Example 2 contains repair ingredients, it lacks antibacterial and anti-inflammatory ingredients, and there is still a risk of inflammation after cleaning.

[0160] Comparative Example 3 uses the traditional surfactant SLS, which has a pH value as high as 8.2 (alkaline). The moisture loss rate after cleansing reaches 25%, which significantly damages the skin's oil layer and causes irritation reactions such as dryness and redness, confirming the necessity of a mild surfactant system.

[0161] In Comparative Example 4 (unactivated nano-inorganic particles), since the nano-silica was not surface activated, the adsorption capacity of the nano-particles decreased, and the water loss rate after cleaning increased to 15% (compared to 8% in Example 1), and the cleaning efficiency was significantly reduced.

[0162] Comparative Example 5 (conventional stirring and emulsification) did not use a high-pressure homogenizer, resulting in uneven distribution of the active ingredients. Although the water loss rate after cleaning (12%) was better than that of Comparative Example 3, it was still higher than that of Example 1.

[0163] Skin Barrier Repair: Examples 1-3, by adding ceramide NPs (0.5-1.2 parts) with a purity of ≥98% and phytosphingosine (0.1-0.3 parts), reduced skin water loss by 30%-50% within 72 hours (Table 2). This actively replenishes barrier lipids and repairs damaged stratum corneum. Example 3, with its highest ceramide NP content (1.2 parts), achieved the highest repair efficiency (50% reduction), making it suitable for skin with severely damaged barrier (such as those following cosmetic procedures).

[0164] In Comparative Example 1, after removing ceramide NPs and phytosphingosine, the water loss reduction rate was only 5%, indicating that the skin's own repair capacity is limited in the absence of exogenous lipid supplementation. In Comparative Example 3, due to the strong irritation of SLS, the water loss reduction rate was -20% (barrier deterioration), further demonstrating the critical role of repair ingredients in barrier health. In Comparative Example 4 (unactivated inorganic nanoparticles), the barrier repair capacity dropped to 35% (compared to 40% in Example 1) because the unactivated nanoparticles were unable to synergize with the lipid replenishment effect of ceramide NPs.

[0165] Synergistic Antibacterial and Anti-inflammatory Effects: Examples 1-3, using tea tree oil nanocapsules (0.5-1 part) with an encapsulation efficiency of ≥85%, achieve long-lasting antibacterial effects, with inhibition rates reaching 88%-95% (Table 2). These effects effectively inhibit pathogens such as Staphylococcus aureus, reducing the risk of acne and folliculitis. Furthermore, dipotassium glycyrrhizate and asiaticoside (1:1 by mass) act synergistically, reducing redness by 50%-75% within 24 hours. Example 3, with its highest content of these ingredients, exhibits the best anti-inflammatory effect (75% reduction), making it suitable for emergency care of sensitive skin.

[0166] Comparative Examples 1 and 2 lacked repair ingredients and antibacterial and anti-inflammatory ingredients respectively, with antibacterial rates of 0%. In addition, the redness reduction rate in Comparative Example 2 was only 5%, which failed to alleviate the inflammatory response. In Comparative Example 3, due to SLS stimulation and activation of the inflammatory pathway, the redness area increased by 15%, highlighting the irreplaceable role of natural anti-inflammatory ingredients.

[0167] In Comparative Example 4 (unactivated inorganic nanoparticles), the antibacterial effect slightly decreased to 88% (92% in Example 1), and the anti-inflammatory effect decreased to 60% (65% in Example 1) due to uneven dispersion of the nanoparticles. In Comparative Example 5 (conventional stirring emulsification), the antibacterial effect (85%) and anti-inflammatory effect (50%) were both lower than those in Example 1 due to insufficient emulsification technology and reduced utilization of the active ingredients.

[0168] Biodegradability and Environmental Friendliness: Examples 1-3 and Comparative Examples 1-2 all utilize readily degradable surfactants such as decyl glucoside, achieving biodegradability of ≥95% (Table 2), meeting environmental standards. However, Comparative Example 3 utilizes SLS, resulting in a degradation rate of only 60%, potentially impacting aquatic ecosystems and further demonstrating the sustainability advantages of the present invention's formulation.

[0169] The embodiment forms technical advantages in cleaning mildness, barrier repair ability and inflammation regulation through the synergistic effect of a mild surfactant system, barrier repair ingredients and natural antibacterial and anti-inflammatory ingredients, while taking into account environmental friendliness, and is significantly better than traditional formulas and comparison examples with missing ingredients.

[0170] While embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions, and variations may be made to these embodiments without departing from the principles and spirit of the invention, and that the scope of the invention is defined by the appended claims and their equivalents.

Claims

1. A skin-friendly cleaning agent, characterized in that: The invention comprises the following raw materials in parts by weight: 8-12 parts of anionic surfactant, 5-8 parts of nonionic surfactant, 3-5 parts of zwitterionic surfactant, 2-4 parts of nano inorganic particles, 0.5-1.2 parts of skin barrier repair agent, 2-3 parts of moisturizer, 0.1-0.3 parts of lipid component, 3-5 parts of polyol, 0.5-1 part of antibacterial nanocapsule, 0.2-0.5 parts of anti-inflammatory component, 0.2-0.5 parts of plant extract, 0.1-0.5 parts of penetration enhancer, and 60-76 parts of solvent.

2. A skin-free cleaning agent according to claim 1, characterized in that: The anionic surfactant is sodium cocoyl glycinate, and its pH value is 5.5-6.0; The nonionic surfactant is decyl glucoside, and its biodegradability is ≥95%; The zwitterionic surfactant is lauramidopropyl betaine.

3. The skin-free cleaning agent according to claim 1, wherein The nano inorganic particles are silicon dioxide with a particle size of 20-50 nm; The skin barrier repair agent is ceramide NP with a purity of ≥98%.

4. The skin-free cleaning agent according to claim 1, wherein The antibacterial nanocapsules are tea tree oil nanocapsules with an encapsulation rate of ≥85%; The anti-inflammatory component includes dipotassium glycyrrhizate, and the plant extract includes asiaticoside, and the mass ratio of the two is 1:

1.

5. The skin-free cleaning agent according to claim 1, wherein: The penetration enhancer is cyclopentasiloxane; The solvent is deionized water, and the conductivity is ≤1 μS / cm.

6. A method for preparing a skin-non-irritating cleanser, for use in the skin-non-irritating cleanser according to any one of claims 1 to 5, characterized in that: The following steps are involved: S1, pretreatment, using a high-pressure homogenizer to encapsulate the antimicrobial active ingredients into nanocapsules, and using a magnetic stirrer to surface activate the nano-inorganic particles; S2, aqueous phase preparation, heating the solvent to 75 ° C in a sandwich reactor, adding anionic surfactant, nonionic surfactant, and zwitterionic surfactant in sequence through a propeller stirrer at 300 rpm, stirring and dissolving; S3, oil phase preparation: melt the skin barrier repair agent, lipid component, and penetration enhancer in a melting tank to 60°C, add the activated nano inorganic particles, and homogenize at 5000 rpm for 5 minutes using a high-pressure homogenizer; S4, emulsification, cooling the water phase to 45°C in an emulsification kettle, slowly adding the oil phase, and homogenizing and emulsifying the mixture at 10,000 rpm for 10 minutes using a high-pressure homogenizer to form an emulsion; S5, functional addition, adding moisturizer, polyol, antibacterial nanocapsule, anti-inflammatory ingredient, and plant extract to the emulsion in a mixing tank, and mixing uniformly using a magnetic stirrer at 50 rpm; S6. Post-treatment: adjust the system pH to 5.5-6.0 with 10% citric acid solution in a pH adjustment tank, degas in a vacuum degassing tank at a vacuum degree of -0.08MPa, and then fill with a filling machine.

7. The method for preparing a skin-non-irritating cleaning agent according to claim 6, characterized in that: The homogenization pressure of the high-pressure homogenizer in step S1 is 50-80 MPa; The activation treatment of the nano inorganic particles includes: soaking them in a 0.1M citric acid solution on a magnetic stirrer for 30-60 minutes.

8. The method for preparing a skin-free cleaning agent according to claim 6, wherein: In the step S4, the temperature of the emulsification kettle is controlled at 44-46° C. during the emulsification process, and the homogenization pressure of the high-pressure homogenizer is 15-20 MPa.

9. The method for preparing a skin-non-irritating cleaning agent according to claim 6, wherein: In step S5, the ambient humidity of the mixing tank is ≤40%, and the temperature fluctuation of the magnetic stirrer is ≤±2°C.

10. The method for preparing a skin-free cleaning agent according to claim 6, wherein: The vacuum degree of the vacuum degassing tank in step S6 is -0.08 MPa.

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