Wound healing electrode, preparation method thereof and electronic bandage

Abstract

The invention provides a wound healing electrode, a preparation method thereof and an electronic bandage, and belongs to the technical field of medical instruments.The wound healing electrode comprises an anode wire harness, a cathode wire harness and a plurality of conductive wire harnesses, the anode wire harness is used for being electrically connected with a positive electrode of a power source, and the cathode wire harness is used for being electrically connected with a negative electrode of the power source; and the cathode wire harnesses and the anode wire harnesses are arranged at intervals. The conductive wire harnesses are at least partially wound on the periphery of one end of the cathode wire harness, the adjacent conductive wire harnesses are arranged at intervals, one end of each conductive wire harness is detachably connected with the anode wire harness, and the other end of each conductive wire harness is arranged at intervals with the cathode wire harness. The wound healing electrode provided by the embodiment of the invention can be adjusted according to the size and shape of the wound, is simple to operate, realizes accurate stimulation, and improves the flexibility.

Description

Technical Field

[0001] The present application relates to the technical field of medical devices, and in particular to a decorative part, a preparation method thereof, and a vehicle. Background Art

[0002] Electronic bandages are advanced medical devices widely used to accelerate wound healing. However, related technologies often suffer from design flaws: the metal electrodes within them are typically fixed in shape and cannot be adjusted to the size and shape of the wound. This limitation can prevent the electrodes from fully contacting the wound surface, thus affecting their therapeutic effectiveness. Furthermore, since the shape and size of the wound may change during the healing process, the fixed-shaped metal electrodes may not be able to adapt to these changes, further limiting the flexibility and application range of electronic bandages. Summary of the Invention

[0003] The embodiments of the present application provide a wound healing electrode and a preparation method thereof, and an electronic bandage, which can be adjusted according to the size and shape of the wound, are simple to operate, achieve precise stimulation, and improve flexibility.

[0004] In order to achieve the above-mentioned object, according to the first aspect of the present application, a wound healing electrode is provided, comprising:

[0005] Anode wiring harness, used for electrical connection to the positive pole of the power supply;

[0006] a cathode wiring harness, used for electrically connecting to the negative pole of the power supply, with the cathode wiring harness and the anode wiring harness being spaced apart;

[0007] Multiple conductive wire bundles are at least partially wound around one end of the cathode wire bundle, and adjacent conductive wire bundles are spaced apart. One end of each conductive wire bundle is detachably connected to the anode wire bundle, and the other end is spaced apart from the cathode wire bundle.

[0008] Optionally, the number of the conductive wire bundles is N, 2≤N≤6.

[0009] Optionally, the anode and cathode bundles include a first conductive fiber bundle;

[0010] And / or, the conductive strands include a second conductive fiber strand.

[0011] Optionally, the first conductive fiber bundle and the second conductive fiber bundle both include a matrix material and a conductive material.

[0012] Optionally, the matrix material comprises polyvinyl alcohol;

[0013] The conductive material includes a poly(3,4-ethylenedioxythiophene)-polystyrene sulfonate composite material.

[0014] Optionally, the plurality of conductive wire bundles include a first sub-conductive wire bundle, a second sub-conductive wire bundle, a third sub-conductive wire bundle and a fourth sub-conductive wire bundle, which are sequentially distributed from the inside to the outside;

[0015] The diameter of the first sub-conductive wire bundle is D1, the diameter of the second sub-conductive wire bundle is D2, the diameter of the third sub-conductive wire bundle is D3, and the diameter of the fourth sub-conductive wire bundle is D4, satisfying: D1≤D2≤D3≤D4.

[0016] Optionally, the diameter of the first sub-conductive wire bundle is 20 μm-30 μm;

[0017] and / or, the diameter of the second sub-conductive wire bundle is 40 μm-50 μm;

[0018] and / or, the diameter of the third sub-conductive wire bundle is 60 μm-70 μm;

[0019] And / or, the straight drop of the fourth sub-conductive wire bundle is 80 μm-90 μm.

[0020] Optionally, the shape of the conductive wire bundle includes at least one of a zigzag shape and a wavy shape.

[0021] Optionally, the wound healing electrode includes an electrode layer, and the anode wire bundle, the cathode wire bundle and the plurality of conductive wire bundles are all arranged on the electrode layer;

[0022] The anode wiring harness and the cathode wiring harness are fixedly connected to the electrode layer, and the plurality of conductive wiring harnesses are detachably connected to the electrode layer.

[0023] Optionally, a plurality of preset cutting lines are provided on the electrode layer, and the preset cutting lines are provided in one-to-one correspondence with the conductive wire bundles, so that the plurality of conductive wire bundles are respectively detachably connected to the electrode layer.

[0024] Optionally, the wound healing electrode further includes a base layer, and the electrode layer is arranged on one side of the base layer.

[0025] According to the second aspect of the present application, a method for preparing a wound healing electrode is also provided, comprising:

[0026] Provided are an anode wiring harness and a cathode wiring harness; wherein the anode wiring harness and the cathode wiring harness are spaced apart;

[0027] A plurality of conductive wire bundles are formed, so that the plurality of conductive wire bundles are at least partially wound around the periphery of one end of the cathode wire bundle, and adjacent conductive wire bundles are spaced apart. One end of each conductive wire bundle is detachably connected to the anode wire bundle, and the other end is spaced apart from the cathode wire bundle to obtain a wound healing electrode.

[0028] Optionally, a plurality of conductive strands are formed, comprising:

[0029] mixing a matrix material solution and a conductive liquid to obtain a spinning solution;

[0030] The spinning solution is electrospun to obtain conductive strands.

[0031] Optionally, the matrix material solution and the conductive liquid are mixed to obtain a spinning solution, comprising:

[0032] Mixing a polyvinyl alcohol solution with a mass percentage of 0.5% to 5% and a poly(3,4-ethylenedioxythiophene)-polystyrene sulfonate composite material solution with a mass percentage of 0.5% to 10% to obtain a spinning solution;

[0033] The mass ratio of the polyvinyl alcohol solution to the poly(3,4-ethylenedioxythiophene)-polystyrene sulfonate composite material solution is (1-6):1.

[0034] Optionally, electrospinning the spinning solution to obtain a conductive strand comprises:

[0035] Set the spinning voltage to 8kV-20kV, the flow rate to 0.3mL / h-0.8mL / h, the distance between the spinning head and the substrate to 20cm-40cm, the humidity to 20%-40%, the temperature to 25℃-28℃, and the spinning time to 20min-60min to obtain a conductive wire bundle.

[0036] According to a third aspect of the present application, an electronic bandage is also provided, comprising the wound healing electrode as described above, and / or a wound healing electrode produced by the method for producing the wound healing electrode as described above.

[0037] The wound healing electrode provided in an embodiment of the present application includes an anode wiring harness, a cathode wiring harness, and multiple conductive wiring harnesses. The anode wiring harness is configured to electrically connect to the positive pole of a power supply, and the cathode wiring harness is configured to electrically connect to the negative pole of the power supply, with the cathode wiring harness and the anode wiring harness spaced apart. The multiple conductive wiring harnesses are at least partially wound around one end of the cathode wiring harness, with adjacent conductive wiring harnesses spaced apart. One end of each conductive wiring harness is detachably connected to the anode wiring harness, and the other end is spaced apart from the cathode wiring harness. The anode wiring harness and the cathode wiring harness are connected to the positive and negative poles of the power supply, respectively, to facilitate electrical stimulation at the wound surface. One end of each conductive wiring harness is detachably connected to the anode wiring harness, and the other end is spaced apart from the cathode wiring harness. The multiple conductive wiring harnesses are at least partially wound around one end of the cathode wiring harness, with adjacent conductive wiring harnesses spaced apart. This allows the conductive wiring harnesses to be electrically connected to the positive pole of the power supply via the anode wiring harness, and allows different conductive wiring harnesses to enclose different areas of different sizes and shapes with the cathode wiring harness. Specific conductive wiring harnesses can be selectively removed and retained based on the size and shape of the wound surface, thereby achieving precise electrical stimulation and improving flexibility. That is, the wound healing electrode provided in the embodiment of the present application can be adjusted according to the size and shape of the wound, is easy to operate, achieves precise stimulation, and improves flexibility.

[0038] Other features and advantages of the present application will be described in detail in the subsequent detailed description. BRIEF DESCRIPTION OF THE DRAWINGS

[0039] To more clearly illustrate the technical solutions in the embodiments of the present application, the following briefly introduces the drawings required for describing the embodiments. Obviously, the drawings described below are only some embodiments of the present application. Those skilled in the art can also derive other drawings based on these drawings without inventive effort.

[0040] In order to more completely understand the present application and its beneficial effects, the following description will be given in conjunction with the accompanying drawings, wherein the same drawing numbers represent the same parts in the following description.

[0041] Figure 1 This is a schematic diagram of the structure of the healing electrode provided in the embodiment of the present application. Figure 1 ;

[0042] Figure 2 yes Figure 1 Enlarged view of point A in the middle;

[0043] Figure 3 This is a schematic diagram of the structure of the healing electrode provided in the embodiment of the present application. Figure 2 ;

[0044] Figure 4 This is a schematic diagram of the structure of the healing electrode provided in the embodiment of the present application. Figure 3 ;

[0045] Figure 5 This is a schematic diagram of the structure of the healing electrode provided in the embodiment of the present application. Figure 4 ;

[0046] Figure 6 This is a schematic diagram of the structure of the healing electrode provided in the embodiment of the present application. Figure 5 ;

[0047] Figure 7 This is a schematic diagram of the structure of the healing electrode provided in the embodiment of the present application. Figure 6 ;

[0048] Figure 8 is a scanning electron microscope image of the conductive wire bundle provided in an embodiment of the present application;

[0049] Figure 9 1 is a diagram showing the biocompatibility test results of the healing electrode provided in an embodiment of the present application;

[0050] Figure 10 is a graph showing the relationship between tensile modulus and resistivity provided in the embodiments of the present application;

[0051] Figure 11This is a graph showing the relationship between ultraviolet light irradiation time and resistivity provided in an embodiment of the present application.

[0052] Description of reference numerals:

[0053] 10. Anode wire harness; 20. Cathode wire harness; 30. Conductive wire harness; 31. First sub-conductive wire harness; 32. Second sub-conductive wire harness; 33. Third sub-conductive wire harness; 34. Fourth sub-conductive wire harness; 40. Electrode layer; 41. Preset cutting line; 50. Base layer. DETAILED DESCRIPTION

[0054] The following will be combined with the drawings in the embodiments of the present application to clearly and completely describe the technical solutions in the embodiments of the present application. Obviously, the embodiments described are only part of the embodiments of the present application, not all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative work are within the scope of protection of the present application.

[0055] First, see Figure 1 and Figure 2 The embodiment of the present application provides a wound healing electrode including an anode wire bundle 10, a cathode wire bundle 20 and a plurality of conductive wire bundles 30. The anode wire bundle 10 is used to electrically connect to the positive pole of a power source, and the cathode wire bundle 20 is used to electrically connect to the negative pole of a power source, and the cathode wire bundle 20 and the anode wire bundle 10 are spaced apart. The plurality of conductive wire bundles 30 are at least partially wound around the periphery of one end of the cathode wire bundle 20, and adjacent conductive wire bundles 30 are spaced apart. One end of each conductive wire bundle 30 is detachably connected to the anode wire bundle 10, and the other end is spaced apart from the cathode wire bundle 20. The anode wire bundle 10 and the cathode wire bundle 20 are connected to the positive and negative poles of the power source, respectively, which helps to form electrical stimulation at the wound surface. One end of each conductive wire bundle 30 is detachably connected to the anode wire bundle 10, and the other end is spaced apart from the cathode wire bundle 20, and multiple conductive wire bundles 30 are at least partially wound around the periphery of one end of the cathode wire bundle 20. Adjacent conductive wire bundles 30 are spaced apart, so that the conductive wire bundles 30 can be electrically connected to the positive pole of the power supply through the anode wire bundle 10, and different conductive wire bundles 30 and cathode wire bundles 20 are enclosed to form areas of different sizes and shapes. Specific conductive wire bundles 30 can be selectively removed and retained according to the size and shape of the wound, thereby achieving precise electrical stimulation and improving flexibility. That is, the wound healing electrode provided in the embodiment of the present application can be adjusted according to the size and shape of the wound, is simple to operate, achieves precise stimulation, and improves flexibility.

[0056] Wound healing is a complex physiological process. When a wound forms, the endogenous electric field in the skin can induce keratinocyte migration, thereby promoting wound healing. In recent years, research has shown that electrical stimulation therapy can be used to promote wound healing on the skin surface. By applying electrical stimulation to electrodes at the wound site, mimicking the endogenous electric field, it can induce epidermal cells to migrate toward the cathode, thereby promoting the repair and regeneration of skin tissue.

[0057] The wound healing electrode provided in the embodiments of the present application is provided with multiple conductive wire bundles 30, each of which is detachably connected to the anode wire bundle 10. These wire bundles 30 can be combined with one end of the cathode wire bundle 20 to form areas of varying sizes and shapes, thereby adapting to varying wound sizes and shapes and improving flexibility. Specifically, the corresponding conductive wire bundle 30 can be removed based on the size and shape of the wound, while the appropriate conductive wire bundle 30 can be retained. This ensures that the size and shape of the area formed by the conductive wire bundle 30 and one end of the cathode wire bundle 20 correspond to the size and shape of the wound, achieving more precise electrical stimulation and improving flexibility.

[0058] In some embodiments, the number of conductive strands 30 is N, where 2≤N≤6.

[0059] By setting the number of conductive bundles 30 to 2-6, it can be adapted to different wound sizes and shapes, ensuring good flexibility. At the same time, it can also ensure the structural compactness of the wound healing electrode, reduce the complexity and manufacturing difficulty of the wound healing electrode, that is, it can balance the flexibility and structural compactness of the wound healing electrode.

[0060] For example, the number of the conductive strands 30 may be 2, 3, 4, 5 or 6.

[0061] In some embodiments, the anode and cathode bundles 10 and 20 include first conductive fiber bundles.

[0062] Compared to conventional metal wire bundles, the inclusion of a first conductive fiber bundle in cathode wire bundle 20 avoids potential safety hazards to patients, such as the prolonged metabolism of metal ions in the body caused by oxidation of the metal bundle, leading to heavy metal accumulation. Furthermore, the soft material of the first conductive fiber bundle improves contact with the wound surface, providing greater comfort and suitability for long-term use.

[0063] In some embodiments, the conductive strands 30 include a second conductive fiber strand.

[0064] Similarly, by including a second conductive fiber bundle in the conductive wire bundle 30, safety hazards to the patient's health, such as the prolonged metabolism of metal ions in the body caused by oxidation of the metal bundle and the accumulation of heavy metals, can be avoided. Furthermore, the second conductive fiber bundle is made of a soft material, which improves its conformity to the wound surface, providing greater comfort and suitability for long-term use. In some embodiments, both the first and second conductive fiber bundles comprise a base material and a conductive material.

[0065] The matrix material forms the main framework of the first and second conductive fiber bundles, providing a carrier for the conductive material to adhere to and support, thereby ensuring the physical properties of the first and second conductive fiber bundles, such as structural strength, flexibility, and corrosion resistance. The conductive material imparts electrical conductivity to the first and second conductive fiber bundles, enabling current to be conducted within them. By including the matrix material and the conductive material in the first and second conductive fiber bundles, the fibers can exhibit excellent mechanical and processability while also exhibiting good electrical conductivity.

[0066] In some embodiments, the matrix material includes polyvinyl alcohol. Polyvinyl alcohol (PVA) has good water solubility, can form a uniform solution, and has good film-forming properties, biocompatibility, and chemical stability, which can ensure the stability and biocompatibility of the first conductive fiber bundle and the second conductive fiber bundle.

[0067] In some embodiments, the conductive material includes a poly(3,4-ethylenedioxythiophene)-polystyrene sulfonate composite material.

[0068] The poly(3,4-ethylenedioxythiophene)-polystyrene sulfonate composite (PEDOT:PSS) is a composite of poly(3,4-ethylenedioxythiophene) (PEDOT) and polystyrene sulfonic acid (PSS). PEDOT is the primary conductive component, while PSS acts as a dispersant, improving PEDOT's solubility. PEDOT:PSS exhibits high conductivity, excellent flexibility, processability, and thermal stability. As the conductive material for the first and second conductive fiber bundles, it ensures good conductivity and imparts excellent flexibility.

[0069] In some embodiments, see Figure 1 、 Figure 3-Figure 6 The plurality of conductive wire bundles 30 include a first sub-conductive wire bundle 31, a second sub-conductive wire bundle 32, a third sub-conductive wire bundle 33, and a fourth sub-conductive wire bundle 34, which are sequentially arranged from the inside out. The diameter of the first sub-conductive wire bundle 31 is D1, the diameter of the second sub-conductive wire bundle 32 is D2, the diameter of the third sub-conductive wire bundle 33 is D3, and the diameter of the fourth sub-conductive wire bundle 34 is D4, satisfying the following: D1≤D2≤D3≤D4.

[0070] The first sub-conductive wire bundle 31, the second sub-conductive wire bundle 32, the third sub-conductive wire bundle 33, and the fourth sub-conductive wire bundle 34, which are distributed sequentially from the inside to the outside, can each enclose one end of the cathode wire bundle 20 to form areas of different sizes, thereby adapting to wounds of different sizes. The area enclosed by the first sub-conductive wire bundle 31 is smaller, while the areas enclosed by the second sub-conductive wire bundle 32, the third sub-conductive wire bundle 33, and the fourth sub-conductive wire bundle 34 gradually increase. By ensuring that the diameter D1 of the first sub-conductive wire bundle 31, the diameter D2 of the second sub-conductive wire bundle 32, the diameter D3 of the third sub-conductive wire bundle 33, and the diameter D4 of the fourth sub-conductive wire bundle 34 meet the requirements of D1≤D2≤D3≤D4, the conductive wire bundle 30 corresponding to a larger wound can generate stronger electrical stimulation, thereby having a better healing effect.

[0071] In some embodiments, the diameter of the first sub-conductive wire bundle 31 is 20 μm-30 μm.

[0072] By making the diameter of the first sub-conductive bundle 31 within the above range, the mechanical properties and flexibility of the first sub-conductive bundle 31 can be guaranteed, and the first sub-conductive bundle 31 can have appropriate electrical stimulation capabilities to ensure the healing effect on the wound surface.

[0073] Exemplarily, the diameter of the first sub-conductive wire bundle 31 may be 20 μm, 22 μm, 24 μm, 26 μm, 28 μm, or 30 μm.

[0074] In some embodiments, the diameter of the second conductive sub-bundle 32 is 40 μm-50 μm.

[0075] By ensuring that the diameter of the second sub-conductive bundle 32 is within the above range, the mechanical properties and flexibility of the second sub-conductive bundle 32 can be ensured, and the second sub-conductive bundle 32 has appropriate electrical stimulation capabilities to ensure the healing effect on the wound surface.

[0076] For example, the diameter of the second sub-conductive wire bundle 32 may be 40 μm, 42 μm, 44 μm, 46 μm, 48 μm, or 50 μm.

[0077] In some embodiments, the diameter of the third sub-conductive wire bundle 33 is 60 μm-70 μm.

[0078] By making the diameter of the third sub-conductive bundle 33 within the above range, the mechanical properties and flexibility of the third sub-conductive bundle 33 can be guaranteed, and the third sub-conductive bundle 33 can have appropriate electrical stimulation capabilities to ensure the healing effect on the wound surface.

[0079] For example, the diameter of the third sub-conductive wire bundle 33 may be 60 μm, 62 μm, 64 μm, 66 μm, 68 μm, or 70 μm.

[0080] In some embodiments, the fourth sub-conductive wire bundle 34 has a straight drop of 80 μm-90 μm.

[0081] By making the diameter of the fourth sub-conductive bundle 34 within the above range, the mechanical properties and flexibility of the fourth sub-conductive bundle 34 can be guaranteed, and the fourth sub-conductive bundle 34 can have appropriate electrical stimulation capabilities to ensure the healing effect on the wound surface.

[0082] For example, the diameter of the fourth sub-conductive wire bundle 34 may be 80 μm, 82 μm, 84 μm, 86 μm, 88 μm, or 90 μm.

[0083] Understandably, see Figure 3-Figure 6 Different conductive wire bundles 30 can correspond to different wound sizes. For example, see Figure 3 When the diameter of the wound is less than or equal to 1.5 cm, the first sub-conductive wire bundle 31 can be retained, and the second sub-conductive wire bundle 32, the third sub-conductive wire bundle 33 and the fourth sub-conductive wire bundle 34 can be removed; please refer to Figure 4 When the diameter of the wound is greater than 1.5 cm and less than or equal to 2 cm, the second sub-conductive wire bundle 32 can be retained, and the first sub-conductive wire bundle 31, the third sub-conductive wire bundle 33 and the fourth sub-conductive wire bundle 34 can be removed; please refer to Figure 5 When the diameter of the wound is greater than 2 cm and less than or equal to 2.5 cm, the third sub-conductive wire bundle 33 can be retained, and the first sub-conductive wire bundle 31, the second sub-conductive wire bundle 32 and the fourth sub-conductive wire bundle 34 can be removed; please refer to Figure 6 When the diameter of the wound is greater than 2.5 cm and less than or equal to 3 cm, the fourth sub-conductive wire bundle 34 can be retained, and the first sub-conductive wire bundle 31, the second sub-conductive wire bundle 32 and the third sub-conductive wire bundle 33 can be removed.

[0084] In some embodiments, the conductive wire bundle 30 may have at least one of a zigzag shape and a wavy shape. This allows the conductive wire bundle 30 to have good scalability, maintain a high field strength per unit area, and enhance the electrical stimulation effect.

[0085] In some embodiments, see Figures 1-6 The wound healing electrode includes an electrode layer 40, on which the anode wire bundle 10, the cathode wire bundle 20, and the plurality of conductive wire bundles 30 are all disposed. The anode wire bundle 10 and the cathode wire bundle 20 are fixedly connected to the electrode layer 40, and the plurality of conductive wire bundles 30 are detachably connected to the electrode layer 40.

[0086] The fixed connection of the anode and cathode wiring harnesses 10 and 20 to the electrode layer 40 ensures the stability of basic electrical functions and the reliability and stability of current transmission. The detachable connection of multiple conductive wiring harnesses 30 to the electrode layer 40 allows different conductive wiring harnesses 30 to be used in conjunction with the anode and cathode wiring harnesses 10 and 20, improving flexibility and adaptability to different wound surfaces.

[0087] In some embodiments, see Figure 2 A plurality of preset cutting lines 41 are provided on the electrode layer 40 , and the preset cutting lines 41 are provided in one-to-one correspondence with the conductive wire bundles 30 , so that the plurality of conductive wire bundles 30 are detachably connected to the electrode layer 40 .

[0088] By setting the pre-cutting lines and the conductive wire bundles 30 in one-to-one correspondence, the conductive wire bundles 30 can be removed from the electrode layer 40 through the corresponding preset cutting lines 41, so that the appropriate conductive wire bundles 30 can be selected according to the conditions of the wound surface, thereby improving the accuracy of electrical stimulation.

[0089] It is understood that the pre-cutting line refers to a cutting path pre-designed on the electrode layer 40. The pre-cutting line can facilitate the removal of the corresponding conductive wire bundle 30 from the electrode layer 40.

[0090] In some embodiments, see Figure 7 The wound healing electrode further includes a base layer 50 , and the electrode layer 40 is disposed on one side of the base layer 50 .

[0091] By providing the base layer 50 , the structural strength and stability of the wound healing electrode can be enhanced, good electrical stimulation performance can be maintained, and the wound healing effect can be improved.

[0092] According to the second aspect of the present application, a method for preparing a wound healing electrode is also provided, comprising:

[0093] Provided are an anode wire harness 10 and a cathode wire harness 20; wherein the anode wire harness 10 and the cathode wire harness 20 are spaced apart;

[0094] A plurality of conductive wire bundles 30 are formed, so that the plurality of conductive wire bundles 30 are at least partially wound around the periphery of one end of the cathode wire bundle 20, and adjacent conductive wire bundles 30 are spaced apart. One end of each conductive wire bundle 30 is detachably connected to the anode wire bundle 10, and the other end is spaced apart from the cathode wire bundle 20, thereby obtaining a wound healing electrode.

[0095] The preparation method of the wound healing electrode provided in the embodiment of the present application has all the beneficial effects of the wound healing electrode described above, which will not be repeated here.

[0096] In some embodiments, forming a plurality of conductive strands 30 includes:

[0097] mixing a matrix material solution and a conductive liquid to obtain a spinning solution;

[0098] The spinning solution is electrospun to obtain conductive strands 30 .

[0099] That is, the conductive wire bundle 30 is produced by spinning, and the morphology and size of the conductive wire bundle 30 can be controlled to ensure good mechanical properties and conductive properties, and the preparation process is simple and efficient.

[0100] In some embodiments, the matrix material solution and the conductive liquid are mixed to obtain a spinning solution, comprising:

[0101] Mixing a polyvinyl alcohol solution with a mass percentage of 0.5% to 5% and a poly(3,4-ethylenedioxythiophene)-polystyrene sulfonate composite material solution with a mass percentage of 0.5% to 10% to obtain a spinning solution;

[0102] The mass ratio of the polyvinyl alcohol solution to the poly(3,4-ethylenedioxythiophene)-polystyrene sulfonate composite material solution is (1-6):1.

[0103] Polyvinyl alcohol has excellent fiber-forming properties and can be formed into continuous, uniform fibers through electrospinning, providing the basic structural framework for the conductive strands 30. Polyvinyl alcohol also has good biocompatibility, resulting in excellent flexibility for the conductive strands 30, improving fit and reducing discomfort. The poly(3,4-ethylenedioxythiophene)-polystyrene sulfonate composite material exhibits excellent conductivity and good stability, ensuring the conductive properties of the conductive strands 30.

[0104] By adjusting the mass ratio of the polyvinyl alcohol solution to the poly(3,4-ethylenedioxythiophene)-polystyrene sulfonate composite material solution to (1-6):1, the fiber forming property and the electrical conductivity can be balanced, thereby obtaining a conductive wire bundle 30 having both good mechanical properties and electrical conductivity.

[0105] For example, in the polyvinyl alcohol solution, the mass percentage of polyvinyl alcohol may be 0.5%, 1%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, or 5%. In the poly(3,4-ethylenedioxythiophene)-polystyrene sulfonate composite material solution, the mass percentage of the poly(3,4-ethylenedioxythiophene)-polystyrene sulfonate composite material may be 0.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, 5%, 5.5%, 6%, 6.5%, 7%, 7.5%, 8%, 8.5%, 9%, 9.5%, or 10%. The mass ratio of the polyvinyl alcohol solution to the poly(3,4-ethylenedioxythiophene)-polystyrene sulfonate composite material solution may be 1:1, 2:1, 3:1, 4:1, 5:1, or 6:1.

[0106] It can be understood that since the diameters of different conductive bundles 30 are different, the concentration of the polyvinyl alcohol solution and the concentration of the poly(3,4-ethylenedioxythiophene)-polystyrene sulfonate composite material solution can be adjusted, and different solution ratios can also be set to ensure that the diameter and conductivity of the corresponding conductive bundle 30 meet the requirements.

[0107] In some embodiments, the spinning solution is electrospun to obtain the conductive strands 30, comprising:

[0108] The spinning voltage is set to 8 kV-20 kV, the flow rate is set to 0.3 mL / h-0.8 mL / h, the distance between the spinning head and the substrate is set to 20 cm-40 cm, the humidity is set to 20%-40%, the temperature is set to 25° C.-28° C., and the spinning time is set to 20 min-60 min to obtain a conductive bundle 30.

[0109] By controlling parameters such as spinning voltage, flow rate, distance between the spinning head and the electrode layer 40, ambient humidity, temperature, and spinning time, the performance of the produced conductive wire bundle 30 can be ensured to meet the requirements, and conductive wire bundles 30 of different diameters can be obtained by adjusting the parameters.

[0110] Exemplarily, the spinning voltage can be 8 kV, 10 kV, 12 kV, 14 kV, 16 kV, 18 kV or 20 kV, the flow rate can be 0.3 mL / h, 0.4 mL / h, 0.5 mL / h, 0.6 mL / h, 0.7 mL / h or 0.8 mL / h, the distance between the spinning head and the substrate can be 20 cm, 25 cm, 30 cm, 35 cm or 40 cm, the ambient humidity can be 20%, 25%, 30%, 35% or 40%, the temperature can be 25°C, 26°C, 27°C or 28°C, and the spinning time can be 20 min, 25 min, 30 min, 35 min, 40 min, 45 min, 50 min, 55 min or 60 min.

[0111] According to a third aspect of the present application, an electronic bandage is also provided, comprising the wound healing electrode as described above, and / or a wound healing electrode produced by the method for producing the wound healing electrode as described above.

[0112] The electronic bandage provided in the embodiment of the present application has all the beneficial effects of the healing electrode as described above, which will not be described in detail here.

[0113] The following examples are further described in conjunction with specific embodiments. It should be understood that these embodiments are intended to illustrate the present invention only and are not intended to limit the scope of the present invention. The experimental methods in the following examples where specific conditions are not specified are generally based on the conditions recommended by the manufacturer.

[0114] Example 1

[0115] In this embodiment, the healing electrode includes an anode harness 10, a cathode harness 20, and a first sub-conductive harness 31, a second sub-conductive harness 32, a third sub-conductive harness 33, and a fourth sub-conductive harness 34. The anode harness 10 is used to electrically connect to the positive pole of a power source, while the cathode harness 20 is used to electrically connect to the negative pole of a power source. The cathode harness 20 and the anode harness 10 are spaced apart. The first sub-conductive harness 31, the second sub-conductive harness 32, the third sub-conductive harness 33, and the fourth sub-conductive harness 34 are wound around one end of the cathode harness 20, with adjacent sub-conductive harnesses 30 spaced apart. Each sub-conductive harness 30 has one end detachably connected to the anode harness 10, and the other end is spaced apart from the cathode harness 20. The anode wire bundle 10 , cathode wire bundle 20 and the first sub-conductive wire bundle 31 , the second sub-conductive wire bundle 32 , the third sub-conductive wire bundle 33 and the fourth sub-conductive wire bundle 34 are all disposed on the electrode layer 40 , and the electrode layer 40 is disposed on one side of the base layer 50 .

[0116] Among them, the preparation method of the first sub-conductive wire bundle 31 is as follows: 2% by mass of polyvinyl alcohol is stirred evenly under heating conditions, and 1% by mass of PEDOT:PSS (poly(3,4-ethylenedioxythiophene)-polystyrene sulfonate composite material) solution is added according to a mass ratio of 1:1. After stirring evenly, a spinning solution is obtained for standby use, the spinning voltage is set to 10KV, the flow rate is 1mL / h, the distance between the collector and the spinning head is 20cm, 1mL of the spinning solution is taken into the spinning syringe, and the spinning is carried out for 20min at a humidity of 35% and a temperature of 26°C. After the spinning is carried out for 20min, the shape is arranged, and after drying, ultraviolet irradiation is carried out for 30min to obtain a first sub-conductive wire bundle 31 with a diameter of 20μm;

[0117] The second sub-conductive wire bundle 32 was prepared by stirring 3% by mass of polyvinyl alcohol under heating conditions, adding 1.5% by mass of a PEDOT:PSS (poly(3,4-ethylenedioxythiophene)-polystyrene sulfonate composite material) solution at a mass ratio of 1:1, and stirring to obtain a spinning solution for use. The spinning voltage was set to 10 kV, the flow rate was 1.5 mL / h, and the distance between the collector and the spinning head was 22 cm. 1 mL of the spinning solution was placed in a spinning syringe, and the spinning was carried out for 30 minutes at a humidity of 35% and a temperature of 26° C. After shaping, the solution was dried and then irradiated with ultraviolet light for 30 minutes to obtain a second sub-conductive wire bundle 32 with a diameter of 43 μm.

[0118] The third sub-conductive wire bundle 33 was prepared by stirring 4% by mass of polyvinyl alcohol under heating conditions, adding 2% by mass of a PEDOT:PSS (poly(3,4-ethylenedioxythiophene)-polystyrene sulfonate composite material) solution at a mass ratio of 1:1, and stirring to obtain a spinning solution for use. The spinning voltage was set to 10 kV, the flow rate was set to 2 mL / h, and the distance between the collector and the spinning head was set to 25 cm. 1 mL of the spinning solution was placed in a spinning syringe, and the spinning was carried out for 40 minutes at a humidity of 35% and a temperature of 26° C. After shaping, the solution was dried and then irradiated with ultraviolet light for 30 minutes to obtain a third sub-conductive wire bundle 33 with a diameter of 62 μm.

[0119] The fourth sub-conductive wire bundle 34 was prepared by stirring 6% polyvinyl alcohol by mass under heating conditions, adding 3% PEDOT:PSS (poly(3,4-ethylenedioxythiophene)-polystyrene sulfonate composite material) solution by mass in a 1:1 mass ratio, and stirring to obtain a spinning solution for use. The spinning voltage was set to 10 kV, the flow rate was 2.5 mL / h, and the distance between the collector and the spinning head was 30 cm. 1 mL of the spinning solution was placed in a spinning syringe. The spinning was carried out for 50 minutes at a humidity of 35% and a temperature of 26°C. The shape was adjusted, and the solution was dried and then irradiated with ultraviolet light for 30 minutes to obtain a fourth sub-conductive wire bundle 34 with a diameter of 83 μm.

[0120] The preparation method of the cathode beam 20 is as follows: 7% by mass of polyvinyl alcohol is stirred evenly under heating conditions, and 3.5% by mass of PEDOT:PSS (poly(3,4-ethylenedioxythiophene)-polystyrene sulfonate composite material) solution is added according to a mass ratio of 1:1. After stirring evenly, a spinning solution is obtained for use. The spinning voltage is set to 10KV, the flow rate is 1.8mL / h, and the distance between the collector and the spinning head is 28cm. 1mL of the spinning solution is taken into the spinning syringe, and the spinning is carried out for 40 minutes at a humidity of 35% and a temperature of 26°C. After the shape is adjusted, it is dried and irradiated with ultraviolet light for 30 minutes to obtain a cathode beam 20 with a diameter of 90μm.

[0121] Example 2

[0122] Among them, the preparation method of the first sub-conductive wire bundle 31 is as follows: 0.5% by mass of polyvinyl alcohol is stirred evenly under heating conditions, and 0.5% by mass of PEDOT:PSS (poly(3,4-ethylenedioxythiophene)-polystyrene sulfonate composite material) solution is added according to a mass ratio of 1:1. After stirring evenly, a spinning solution is obtained for standby use, the spinning voltage is set to 10KV, the flow rate is 0.3mL / h, the distance between the collector and the spinning head is 20cm, 1mL of the spinning solution is taken into the spinning syringe, and the spinning is carried out for 30min at a humidity of 28% and a temperature of 28°C. After the spinning is carried out, the shape is arranged, and after drying, ultraviolet irradiation is carried out for 30min to obtain a first sub-conductive wire bundle 31 with a diameter of 20μm;

[0123] The second sub-conductive wire bundle 32 is prepared by stirring 10% by mass of polyvinyl alcohol under heating conditions, adding 7% by mass of a PEDOT:PSS (poly(3,4-ethylenedioxythiophene)-polystyrene sulfonate composite material) solution at a mass ratio of 4:1, and stirring to obtain a spinning solution for use. The spinning voltage is set to 10 kV, the flow rate is 2.5 mL / h, and the distance between the collector and the spinning head is 30 cm. 1 mL of the spinning solution is placed in a spinning syringe, and the spinning is carried out for 30 minutes at a humidity of 40% and a temperature of 28° C. After shaping, the solution is dried and then irradiated with ultraviolet light for 30 minutes to obtain a second sub-conductive wire bundle 32 with a diameter of 50 μm.

[0124] The third sub-conductive wire bundle 33 was prepared by stirring 12% by mass of polyvinyl alcohol under heating conditions, adding 7% by mass of a PEDOT:PSS (poly(3,4-ethylenedioxythiophene)-polystyrene sulfonate composite material) solution at a mass ratio of 2:1, and stirring to obtain a spinning solution for use. The spinning voltage was set to 10 kV, the flow rate was 5 mL / h, and the distance between the collector and the spinning head was 40 cm. 1 mL of the spinning solution was placed in a spinning syringe, and the spinning was carried out for 20 minutes at a humidity of 40% and a temperature of 28° C. After shaping, the solution was dried and then irradiated with ultraviolet light for 30 minutes to obtain a third sub-conductive wire bundle 33 with a diameter of 70 μm.

[0125] The fourth sub-conductive wire bundle 34 was prepared by stirring 13% polyvinyl alcohol by mass under heating conditions, adding 8% PEDOT:PSS (poly(3,4-ethylenedioxythiophene)-polystyrene sulfonate composite material) solution by mass in a mass ratio of 4:1, and stirring to obtain a spinning solution for use. The spinning voltage was set to 10 kV, the flow rate was 6 mL / h, and the distance between the collector and the spinning head was 40 cm. 1 mL of the spinning solution was placed in a spinning syringe. The spinning was carried out for 20 minutes at a humidity of 40% and a temperature of 27°C. The shape was adjusted, and the solution was dried and then irradiated with ultraviolet light for 30 minutes to obtain a fourth sub-conductive wire bundle 34 with a diameter of 90 μm.

[0126] The preparation method of the cathode beam 20 is as follows: 15% by mass of polyvinyl alcohol is stirred evenly under heating conditions, and 10% by mass of PEDOT:PSS (poly(3,4-ethylenedioxythiophene)-polystyrene sulfonate composite material) solution is added according to a mass ratio of 6:1. After stirring evenly, a spinning solution is obtained for use. The spinning voltage is set to 10KV, the flow rate is 8mL / h, and the distance between the collector and the spinning head is 40cm. 1mL of the spinning solution is taken into the spinning syringe, and the spinning is carried out for 35 minutes at a humidity of 40% and a temperature of 28°C. After the shape is adjusted, it is dried and irradiated with ultraviolet light for 30 minutes to obtain a cathode beam 20 with a diameter of 100μm.

[0127] The healing electrode prepared in the embodiment was subjected to SEM (scanning electron microscope) testing, biocompatibility testing, electrochemical stability testing, resistivity testing, and durability testing. The SEM test method is as follows: the sample to be tested is pasted on the target stage, vacuum-sprayed with gold, placed in the SEM sample chamber for observation, and the sample to be tested is scanned and analyzed at an accelerating voltage of 2 kV. The biocompatibility test method is as follows: 2 mM Calcein-AM and 2 mM PI solutions are prepared using 5 mL of 1×PBS with a pH of 7.4 as a solvent, the adherent cells are cultured until fusion, 200 μL of the cell suspension is centrifuged, mixed with 100 μL of the staining working solution, and incubated at 37 ° C for 30 minutes. Live and dead cell staining was observed under a fluorescence microscope using a 490nm excitation filter. The electrochemical stability test method was as follows: the resistance change was measured by applying an electrical stimulus of 1.1V for 30 minutes / day in a simulated human body environment (DPBS, 37°C, pH = 7.4) to verify its suitability as a bioelectrode. The resistivity test method was as follows: a 10cm long second sub-conductive wire bundle 32 was stretched using a test tensile machine and its resistivity was tested using a dual-probe digital power supply. The durability test method was as follows: a 10cm long second sub-conductive wire bundle 32 was placed in a UV curing box for a set time, and then removed and the resistivity was tested using a dual-probe digital power supply.

[0128] Please refer to Figure 8 for the test results. Figure 11 And Table 1-Table 2:

[0129] Table 1 Comparison of resistivity of conductive wire bundle 30 under different tensile moduli

[0130]

[0131]

[0132] Table 2 Comparison of resistivity of conductive wire bundle 30 at different UV irradiation times

[0133] Time / min <![CDATA[Resistivity / 10 -2 Ω·cm]]> 0 3 60 3.1 120 3.2 180 3.6 240 3.8 300 4.9 360 5.7 420 7.2 480 9.5

[0134] See also Figure 8 , the conductive strands are composed of multiple conductive fibers, and the diameter of a single conductive fiber is about 0.5μm. Figure 9 The cell survival rate on the healing electrode surface is 100%, and it has good biocompatibility. Figure 10 As shown in Table 1, the resistivity decreases with the increase of tensile modulus, and the resistivity is the highest when no stretching is performed, which is 0.028Ω·cm. Figure 11 As shown in Table 2, by irradiating the conductive wire bundle 30 with ultraviolet light, the resistivity of the conductive wire bundle 30 can be increased and the service life can be reduced. In the embodiment of the present application, the resistivity of the healing electrode does not change significantly when the ultraviolet light irradiation time is within 180 minutes, indicating that the healing electrode provided by the embodiment of the present application has good durability.

[0135] In the description of this application, the terms "first" and "second" are used for descriptive purposes only and should not be understood to indicate or imply relative importance or implicitly specify the number of technical features indicated. Therefore, a feature defined as "first" or "second" may explicitly or implicitly include one or more features. In the description of this application, "plurality" means two or more, unless otherwise specifically defined.

[0136] In the above embodiments, the description of each embodiment has its own focus. For parts that are not described in detail in a certain embodiment, reference can be made to the relevant descriptions of other embodiments.

[0137] The embodiments, implementation methods and related technical features of the present application can be combined and replaced with each other without conflict.

[0138] The above are merely preferred embodiments of the present application and do not constitute any form of limitation to the present application. However, any simple modifications, equivalent changes, and modifications made to the above embodiments based on the technical essence of the present application without departing from the content of the technical solution of the present application are still within the scope of the technical solution of the present application.

Claims

1. A wound healing electrode, characterized in that: include: Anode wiring harness, used for electrical connection to the positive pole of the power supply; a cathode wiring harness, configured to be electrically connected to the negative electrode of the power supply, wherein the cathode wiring harness and the anode wiring harness are spaced apart; A plurality of conductive wire bundles are at least partially wound around the periphery of one end of the cathode wire bundle, and adjacent conductive wire bundles are spaced apart, one end of each conductive wire bundle is detachably connected to the anode wire bundle, and the other end is spaced apart from the cathode wire bundle.

2. The wound healing electrode according to claim 1, characterized in that The number of the conductive wire bundles is N, 2≤N≤6.

3. The wound healing electrode according to claim 1, characterized in that The anode wire bundle and the cathode wire bundle include a first conductive fiber bundle; And / or, the conductive thread bundle includes a second conductive fiber bundle.

4. The wound healing electrode according to claim 3, characterized in that The first conductive fiber bundle and the second conductive fiber bundle both include a matrix material and a conductive material.

5. The wound healing electrode according to claim 4, characterized in that: The matrix material includes polyvinyl alcohol; The conductive material includes a poly(3,4-ethylenedioxythiophene)-polystyrene sulfonate composite material.

6. The wound healing electrode according to claim 1, characterized in that The plurality of conductive wire bundles include a first sub-conductive wire bundle, a second sub-conductive wire bundle, a third sub-conductive wire bundle and a fourth sub-conductive wire bundle, which are sequentially distributed from the inside to the outside; The diameter of the first sub-conductive wire bundle is D1, the diameter of the second sub-conductive wire bundle is D2, the diameter of the third sub-conductive wire bundle is D3, and the diameter of the fourth sub-conductive wire bundle is D4, satisfying: D1≤D2≤D3≤D4.

7. The wound healing electrode according to claim 6, characterized in that The diameter of the first sub-conductive wire bundle is 20 μm-30 μm; and / or, the diameter of the second sub-conductive wire bundle is 40 μm-50 μm; And / or, the diameter of the third sub-conductive wire bundle is 60 μm-70 μm; And / or, the fourth sub-conductive wire bundle has a straight drop of 80 μm-90 μm.

8. The wound healing electrode according to claim 1, characterized in that: The conductive wire bundle has a shape including at least one of a zigzag shape and a wavy shape.

9. The wound healing electrode according to any one of claims 1 to 8, characterized in that: The wound healing electrode comprises an electrode layer, and the anode wire bundle, the cathode wire bundle and the plurality of conductive wire bundles are all arranged on the electrode layer; The anode wire harness and the cathode wire harness are fixedly connected to the electrode layer, and the plurality of conductive wire harnesses are detachably connected to the electrode layer.

10. The wound healing electrode according to claim 9, characterized in that: A plurality of preset cutting lines are provided on the electrode layer, and the preset cutting lines are provided in one-to-one correspondence with the conductive wire bundles, so that the plurality of conductive wire bundles are respectively detachably connected to the electrode layer.

11. The wound healing electrode according to claim 9, characterized in that: The wound healing electrode further includes a base layer, and the electrode layer is arranged on one side of the base layer.

12. A method for preparing a wound healing electrode, characterized in that: include: Provided are an anode wire harness and a cathode wire harness; wherein the anode wire harness and the cathode wire harness are spaced apart; A plurality of conductive wire bundles are formed, and the plurality of conductive wire bundles are at least partially wound around the periphery of one end of the cathode wire bundle, and adjacent conductive wire bundles are spaced apart. One end of each conductive wire bundle is detachably connected to the anode wire bundle, and the other end is spaced apart from the cathode wire bundle, thereby obtaining the wound healing electrode.

13. The method for preparing a wound healing electrode according to claim 12, wherein: The forming of a plurality of conductive wire bundles comprises: mixing a matrix material solution and a conductive liquid to obtain a spinning solution; The spinning solution is electrospun to obtain the conductive wire bundle.

14. The method for preparing a wound healing electrode according to claim 13, wherein: The method of mixing the matrix material solution and the conductive liquid to obtain a spinning solution comprises: Mixing a polyvinyl alcohol solution having a mass percentage of 0.5% to 5% with a poly(3,4-ethylenedioxythiophene)-polystyrene sulfonate composite material solution having a mass percentage of 0.5% to 10% to obtain the spinning solution; Wherein, the mass ratio of the polyvinyl alcohol solution to the poly(3,4-ethylenedioxythiophene)-polystyrene sulfonate composite material solution is (1-6):

1.

15. The method for preparing a wound healing electrode according to claim 13, wherein: The electrostatic spinning of the spinning solution to obtain the conductive wire bundle comprises: The spinning voltage is set to 8kV-20kV, the flow rate is set to 0.3mL / h-0.8mL / h, the distance between the spinning head and the substrate is set to 20cm-40cm, the humidity is set to 20%-40%, the temperature is set to 25℃-28℃, and the spinning time is set to 20min-60min to obtain the conductive wire bundle.

16. An electronic bandage, characterized in that: The invention comprises the wound healing electrode according to any one of claims 1 to 11, and / or the wound healing electrode prepared by the preparation method of the wound healing electrode according to any one of claims 12 to 15.

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