Skin care hand sanitizer and method of making same

Abstract

The application discloses a skin-care type hand sanitizer and a preparation method thereof, and relates to the technical field of disinfectants.The technical scheme is as follows: the skin-care type hand sanitizer is composed of the following components in mass percentage: emulsifier: 1-5%; oil phase: 1-5%; skin-care component: 2-8%; bactericidal component: 0.6-3.5%; improved film-forming agent: 0.5-2.5%; synergistic thickening agent: 0.1-0.8%; rheological modifier: 0.05-0.3%; organically modified clay: 0.2-1%; skin-feel adjusting powder: 0.5-2%; volatile silicone oil: 1-3%; acid-base adjusting agent: 1-5%; and the rest is water.The skin-care type hand sanitizer prepared by the application has the intelligent rheological characteristics of standing stability, smooth rubbing, dry freshness and extreme skin feel, and the effect is far superior to that of a product obtained by simple mixing; and through a series of processes with synergistic effects, the two long-standing technical problems of production efficiency and product skin feel are successfully solved at the same time.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of disinfectants, in particular to a skin-care type hand sanitizer and a preparation method thereof. BACKGROUND

[0002] In a medical environment, frequent hand cleaning (such as hand washing, using alcohol-based disinfectants) is a key measure to prevent the spread of disease. However, repeated use of alcohol-based disinfectants by medical staff can cause damage to the skin barrier, leading to dryness, chapping, itching and even dermatitis. Therefore, it is crucial to incorporate skin care functions into hand hygiene (such as using hand washing liquids or disinfectants containing moisturizing and repairing ingredients).

[0003] At present, in order to solve the skin problem, there are disinfectant products on the market which add moisturizing agents such as glycerol and sodium hyaluronate. However, in order to suspend these ingredients and maintain the stability of the system, a large amount of thickening agent or film-forming agent (such as carbomer, HEC) is usually added, and it takes a long time of 4-6h to fully swell and hydrate through long-time stirring, which leads to low production efficiency and cost increase. More importantly, high-viscosity products, although stable, can cause heavy sticky feeling to users, have high resistance when applying, are difficult to rub, have strong film feeling after use, and are not breathable, etc. Traditional products have poor skin feeling immediately after use. For example, Chinese invention patent CN114306149A discloses a leave-on antibacterial skin care disinfectant gel and a preparation method thereof, which uses triethanolamine and carbomer for thickening, but it still has the problem of long thickening time required by carbomer, and high dosage of carbomer will inevitably cause heavy sticky feeling of the product, poor rub resistance, and the user experience has not been fundamentally improved. Therefore, there is an urgent need in the market for a high-efficiency skin-care type disinfectant product that can be quickly produced and provide a refreshing, smooth and pleasant skin feeling. SUMMARY

[0004] The technical problem to be solved by the present application is to overcome the shortcomings of the prior art, provide a skin-care type hand sanitizer and a preparation method thereof, and the prepared skin-care type hand sanitizer has intelligent rheological properties of standing stability, smooth rub resistance and refreshing dryness, and the effect is much better than that of simply mixed products; and through a series of processes with synergistic effect, the two long-standing technical problems of production efficiency and product skin feeling are successfully solved.

[0005] The technical scheme of the present application is as follows:

[0006] On the one hand, the present application provides a skin-care type hand sanitizer, which is composed of the following components in mass percentage:

[0007] Emulsifier: 1-5%;

[0008] Oil phase: 1-5%;

[0009] Skin care ingredients: 2-8%;

[0010] Bactericidal ingredient: 0.6-3.5%;

[0011] Film forming agent: 0.5-2.5%;

[0012] Synergistic thickening agent: 0.1-0.8%;

[0013] Rheology modifier: 0.05-0.3%;

[0014] Organically modified clay: 0.2-1%;

[0015] Skin feel modifier powder: 0.5-2%;

[0016] Volatile silicone oil: 1-3%;

[0017] Acid-base regulator: 1-5%;

[0018] The rest is water;

[0019] Among them, the bactericidal ingredient is one of chlorhexidine gluconate, benzalkonium chloride, benzalkonium bromide, didecyldimethyl ammonium chloride and p-chloro-m-xylene phenol with 0.1-0.5% ε-polylysine; the synergistic thickening agent is a cross-linked polymer of acrylate and C10-30 alkanol acrylate with a mass ratio of (1-4):1.

[0020] Preferably, the emulsifier is glycerol monostearate, polyglyceryl-3 diisostearate or lanolin alcohol.

[0021] Preferably, the oil phase is glyceryl stearate, capric triglyceride or isopropyl myristate.

[0022] Preferably, the skin care ingredient is one or more of glycerin, sodium hyaluronate, squalane, PEG-7 glyceryl cocoate and allantoin.

[0023] Preferably, the film forming agent is hydrophobically modified hydroxyethyl cellulose; the rheology modifier is sodium magnesium silicate; the organically modified clay is selamectin bentonite.

[0024] Preferably, the skin feel modifier powder is boron nitride or silica; the volatile silicone oil is cyclopentasiloxane; the acid-base regulator is sodium hydroxide, potassium hydroxide or triethanolamine.

[0025] In another aspect, the present application provides a preparation method of the above-mentioned skin care type hand sanitizer, comprising the following steps:

[0026] S1 Preparation of water phase base: In the main reaction kettle A, 60-70wt.% of water is added, and stirring is started; the synergistic thickening agent is added into the main reaction kettle A, and continuous stirring is carried out to make it fully wet and dispersed without fish eyes or lumps;

[0027] S2 Instant thickening: Prepare the rest of the water into an acid-base regulator aqueous solution, and add it into the system within 2-4 min, adjust the pH of the system to 6.2-6.8, and the system becomes a gel base within 60-120 s;

[0028] S3 Dissolution of main components: Add the improved film-forming agent into the gel base, stir until it is completely dissolved, and use the high viscosity characteristics of the gel base to effectively prevent the flying and clumping of light powders; then add the skin care ingredients and the sterilization ingredients in turn, and stir until they are completely dissolved;

[0029] S4 Rheological adjustment: Add the rheological modifier, stir to fully hydrate and gel, and obtain an aqueous phase;

[0030] S5 Oil phase preparation: Add the emulsifier and 0.5-3% of the total mass of the oil phase into reaction kettle B, use the stepwise heating method, first heat it to 58-62℃, keep stirring for 3-7 min, then continue to heat it to 76-80℃, and stir at a speed of 1000-1500 rpm at this temperature for 3-5 min, until the system becomes a transparent and uniform oil phase liquid;

[0031] S6 Emulsification: Cool the aqueous phase in the main reaction kettle A to 42-48℃ and stir; inject the oil phase liquid in reaction kettle B into the aqueous phase through a pipeline shear emulsifier, this process ensures that the oil phase liquid is sheared into micron-sized droplets in an instant, and a preliminary oil-in-water (O / W) emulsion is obtained;

[0032] S7 Intelligent rheology and skin feel construction: Transfer the emulsion to a scraped paddle stirring kettle, cool it to 36-38℃; add the pre-prepared organically modified clay pre-gel, which is prepared by stirring and dispersing organically modified clay with the remaining oil phase; then stir at a speed of 40-60 rpm for 15-20 min, under the same stirring conditions, add the skin feel adjusting powder, and continue to stir for 20-30 min;

[0033] S8 Blending: Cool the system to 26-30℃, add volatile silicone oil, and stir to disperse it evenly, and the skin care type hand sanitizer is obtained.

[0034] Preferably, in step S1, the stirring speed is 450-550 rpm, and continue to stir for 8-12 min after adding the synergistic thickening agent.

[0035] Preferably, in step S3, the stirring speed is 550-650 rpm, and the stirring time is 15-25 min; in step S4, the stirring speed is 800-1000 rpm, and the stirring time is 12-18 min.

[0036] Preferably, in step S6, the stirring speed is 600-800 rpm, and the shear rate is 10000-15000 s -1 ; in step S7, the stirring speed during dispersion is 3000-4000 rpm, and the stirring time is 8-12 min; in step S8, the stirring speed is 30-50 rpm, and the stirring time is 5-8 min.

[0037] The mechanism of the internal composition and skin feel changes of the skin care type hand sanitizer prepared in the application in the three stages of storage, use and after use is as follows:

[0038] Stage one: static storage

[0039] The synergistic thickening agent in the skin care type hand sanitizer can form a weak network structure and play a synergistic building role; the rheological modifier can provide a stable point and enhance the stability of the system; the organically modified clay constructs a "card house" structure as the main framework. These components together form a stable three-dimensional network structure for suspending and fixing the improved film-forming agent and skin care ingredients, so that they are stably wrapped.

[0040] Stage two: when rubbing (applying shear force)

[0041] The "card house" structure is instantly destroyed under the action of shear force, resulting in a sharp decrease in viscosity (shear thinning); the polymer network is oriented and arranged, allowing the volatile silicone oil to spread quickly and bring about an instant and extremely smooth and easy-to-rub skin feel; at the same time, the skin feel adjusting powder starts to absorb, providing a continuous effect for the subsequent skin feel.

[0042] Stage three: after rubbing is completed (shear force disappears)

[0043] The volatile silicone oil is completely volatilized, leaving a clean, matte and non-sticky skin feel; the "card house" structure is quickly rebuilt, and the viscosity is instantly restored, ensuring that the product does not flow and is stable and durable; the improved film-forming agent forms a protective film, providing long-lasting moisturization and protection barrier; the polymer network returns to entanglement, assisting the stability of the overall structure.

[0044] Compared with the prior art, the application has the following beneficial effects:

[0045] 1.The present application constructs an oil-in-water (O / W) emulsion system with alcohol-free bactericidal ingredients as the core, integrating "intelligent rheological system" and "skin feel optimization system". The intelligent rheological system is composed of improved film-forming agent, synergistic thickening agent, rheological modifier and organically modified clay, achieving "instant thickening" and "stability without aging" during production, greatly shortening the production cycle. The skin feel optimization system is composed of organically modified clay, volatile silicone oil and skin feel adjusting powder, giving the product the intelligent characteristics of "stable when standing, smooth when kneading, and clean when dry". The hand sanitizer product prepared finally meets the standard of "GB 27950-2020 General Requirements for Hand Sanitizers" while having significant skin care effect and excellent use experience.

[0046] 2.The present application adopts "instant gelation" technology: using the rapid response characteristics of synergistic thickening agent at a specific pH, a high-viscosity gel base is constructed within 2 minutes, replacing the traditional waiting time of several hours and improving production efficiency. The present application realizes "low-temperature precise emulsification": by controlling the temperature of the water phase (42-48℃) and using online shearing, emulsification is completed at a temperature much lower than the traditional process (70-80℃), greatly reducing energy consumption and protecting heat-sensitive ingredients in hand sanitizer. The present application also adopts "clay pre-dispersion" technology: organically modified clay is pre-dispersed in the oil phase of the formula itself, completely solving the problem of easy clumping and difficult uniform dispersion when directly added to the water phase, which is the key to achieving stable and uniform rheological properties. In addition, the present application adopts "aging-free" process: through the synergy of synergistic thickening agent, rheological modifier and organically modified clay, a stable three-dimensional network structure is formed after emulsification, eliminating the need for the 24-48h aging time required by traditional processes, greatly shortening the process time. In addition, the addition of volatile silicone oil and skin feel adjusting powder in the hand sanitizer of the present application makes the sticky feeling of the product disappear within 1 minute after use, presenting a matte, dry and silky touch.

[0047] 3.The present application solves the three core problems of existing hand sanitizers (especially high skin care ingredient content type hand sanitizers): (1) skin dryness and allergy problems caused by alcohol ingredients; (2) long production time (up to several hours) in the thickening and emulsification process of traditional production process; (3) high viscosity of the product for stability, resulting in sticky, difficult to knead and poor skin feel during use. The skin care type hand sanitizer prepared by the present application has intelligent rheological properties of standing stability, smooth kneading and clean dryness, and has a much better effect than simply mixed products. The preparation method of the present application is not a simple combination of conventional steps, but a series of processes with synergistic effect, successfully solving the long-standing technical problems of production efficiency and product skin feel. DETAILED DESCRIPTION

[0048] In order for the person skilled in the art to better understand the technical solutions in the present application, the technical solutions of the present application will be clearly and completely described below in combination with the embodiments of the present application.

[0049] Embodiment 1

[0050] The skin care type hand sanitizer of the present embodiment is composed of the following components in mass percentage: glycerol monostearate 1%, glyceryl stearate 1%, glycerol 5%, sodium hyaluronate 0.5%, squalane 1%, benzalkonium chloride 2%, ε-polylysine 0.3%, hydrophobically modified hydroxyethyl cellulose 0.5%, acrylate 0.05%, C10-30 alkyl acrylate crosspolymer Pemulen TR-2 0.05%, magnesium sodium silicate 0.05%, selamine bentonite 0.2%, boron nitride 0.5%, cyclopentasiloxane 1%, potassium hydroxide 1.5%, and the rest is deionized water.

[0051] The preparation method of the skin care type hand sanitizer of the present embodiment comprises the following steps:

[0052] S1 Preparation of water phase base: add 63wt.% of deionized water in the total water amount into the main reaction kettle A and stir at a speed of 500rpm; add acrylate and C10-30 alkyl acrylate crosspolymer Pemulen TR-2 into the main reaction kettle A and stir for 10min to make them fully wet and dispersed without fisheyes or lumps;

[0053] S2 Instantaneous activation thickening: prepare an aqueous solution of potassium hydroxide with the remaining deionized water and add it dropwise into the main reaction kettle A within 3min to adjust the pH of the system to 6.5, and the system becomes a gel base within 90s;

[0054] S3 Dissolution of main components: add hydrophobically modified hydroxyethyl cellulose into the gel base and stir at a speed of 600rpm for 20min to dissolve; then add glycerol, sodium hyaluronate, squalane, benzalkonium chloride and ε-polylysine in sequence and stir at a speed of 600rpm for 25min in total;

[0055] S4 Rheological adjustment: add magnesium sodium silicate and stir at a speed of 900rpm for 15min to make it fully hydrated and gelled to obtain the water phase;

[0056] S5 Preparation of oil phase: add glycerol monostearate and 0.5% of glyceryl stearate in the total mass of glyceryl stearate into the reaction kettle B, use the stepwise heating method, first heat it to 60℃, keep stirring for 5min, then continue to heat it to 78℃ and stir at a speed of 1200rpm for 4min to obtain a transparent and uniform oil phase liquid;

[0057] S6 Emulsification: The water phase in main reactor A was cooled to 45°C and stirred at 700 rpm; the oil phase liquid in reactor B was injected into the water phase online through a tubular shear emulsifier (12000 s -1 ) to obtain an emulsion;

[0058] S7 Intelligent rheology and skin feel construction: The emulsion was transferred to a scraped paddle stirred tank and cooled to 37°C; the pre-prepared organically modified clay pre-gel (sodium bentonite prepared by stirring the remaining glycerol stearate at 3500 rpm for 8 min) was added, and the wall was stirred at a speed of 50 rpm for 18 min to make it uniformly dispersed; under the same stirring conditions, boron nitride was added, and the stirring was continued for 25 min to ensure that the powder was completely wetted and dispersed, and no particles were visible to the naked eye;

[0059] S8 Harmonization: The system was cooled to 28°C, and cyclopentasiloxane was added, and stirred at a speed of 40 rpm for 7 min to make it uniformly dispersed, and the skin care type hand sanitizer was obtained.

[0060] Example 2

[0061] The skin care type hand sanitizer of this example is composed of the following components in mass percentage: polyglycerol-3 diisostearate 3%, isopropyl myristate 3%, squalane 2%, PEG-7 glyceryl cocoate 1%, allantoin 0.2%, chlorhexidine gluconate 1.5%, ε-polylysine 0.5%, hydrophobically modified hydroxyethyl cellulose 2.5%, acrylate 0.6%, C10-30 alkyl acrylate cross-linked polymer Pemulen TR-2 0.2%, magnesium sodium silicate 0.3%, sodium bentonite 1%, silica 2%, cyclopentasiloxane 3%, triethanolamine 5%, and the rest is deionized water.

[0062] The preparation method of the skin care type hand sanitizer of this example includes the following steps:

[0063] S1 Water phase base preparation: 60wt.% of deionized water was added to the main reactor A, and stirred at a speed of 550 rpm; acrylate and C10-30 alkyl acrylate cross-linked polymer Pemulen TR-2 were added to the main reactor A, and stirred for 8 min to make it fully wet and dispersed, without fish eyes or lumps;

[0064] S2 Instantaneous activation thickening: The triethanolamine was prepared into an aqueous solution with the remaining deionized water, and was added dropwise to the main reactor A within 2 min, and the pH of the system was adjusted to 6.2, and the system became a gel base within 60 s;

[0065] S3 dissolving main components: hydrophobically modified hydroxyethylcellulose was added into the gel base, stirred at 650 rpm for 15 min to dissolve; then squalane, PEG-7 glyceryl cocoate, allantoin, chlorhexidine gluconate, ε-polylysine were added in turn, and stirred at 650 rpm for 20 min;

[0066] S4 rheology adjustment: sodium magnesium silicate was added, stirred at 1000 rpm for 12 min to fully hydrate and gel the gel, to obtain an aqueous phase;

[0067] S5 oil phase preparation: polyglyceryl-3 diisostearate and 3% (by total mass) isopropyl myristate were added into reaction kettle B, using a stepwise heating method, first heated to 62°C, and stirred for 3 min, then heated to 80°C, and stirred at 1500 rpm for 3 min, to obtain a transparent and uniform oil phase liquid;

[0068] S6 emulsification: the aqueous phase in main reaction kettle A was cooled to 42°C, and stirred at 800 rpm; the oil phase liquid in reaction kettle B was injected into the aqueous phase through a pipeline shear emulsifier (15000 s -1 ) online, to obtain an emulsion;

[0069] S7 intelligent rheology and skin feel construction: the emulsion was transferred to a scraped wall stirring kettle, cooled to 36°C; the pre-prepared organically modified clay pre-gel (sodium chitosan bentonite and the remaining isopropyl myristate were dispersed by stirring at 4000 rpm for 8 min) was added, and stirred at 60 rpm for 15 min to make it uniformly dispersed; under the same stirring conditions, silica was added, and stirred for 20 min to ensure that the powder was fully wetted and dispersed, and no visible particles were present;

[0070] S8 blending: the system was cooled to 26°C, and cyclopentasiloxane was added, and stirred at 50 rpm for 5 min to make it uniformly dispersed, to obtain a skin care type hand sanitizer.

[0071] Example 3

[0072] The skin care type hand sanitizer of this example was composed of the following components in mass percentage: lanolin alcohol 5%, capric triglyceride 5%, glycerol 7.9%, allantoin 0.1%, benzalkonium bromide 3%, ε-polylysine 0.1%, hydrophobically modified hydroxyethylcellulose 1.5%, acrylate 0.3%, C10-30 alkanol acrylate crosspolymer Pemulen TR-2 0.1%, sodium magnesium silicate 0.15%, sodium chitosan bentonite 0.6%, boron nitride 1.2%, cyclopentasiloxane 2%, sodium hydroxide 3%, and the rest was deionized water.

[0073] The preparation method of the skin care type hand sanitizer of the embodiment includes the following steps:

[0074] S1 Water phase base preparation: Add 65wt.% of deionized water in the total water amount to the main reaction kettle A and stir at a speed of 450 rpm; add acrylate and C10-30 alkyl acrylate crosslinking polymer Pemulen TR-2 to the main reaction kettle A, and stir for 12 min to make it fully wet and dispersed without fisheyes or lumps;

[0075] S2 Instantaneous activation thickening: Prepare a sodium hydroxide aqueous solution with the remaining deionized water, and add it dropwise to the main reaction kettle A within 4 min to adjust the pH of the system to 6.8, and the system becomes a gel base within 120 s;

[0076] S3 Dissolution of main ingredients: Add hydrophobically modified hydroxyethyl cellulose to the gel base, and stir at a speed of 550 rpm for 25 min until it is dissolved; then sequentially add glycerol, allantoin, benzalkonium bromide, and ε-polylysine, and stir at a speed of 550 rpm for 30 min;

[0077] S4 Rheological adjustment: Add sodium magnesium silicate, and stir at a speed of 800 rpm for 18 min to make it fully hydrated and gelled to obtain the water phase;

[0078] S5 Oil phase preparation: Add lanolin alcohol and 0.5% of the total mass of capric acid triglyceride to the reaction kettle B, and use the stepwise heating method to first heat it to 58℃, maintain stirring for 7 min, then continue to heat it to 76℃, and stir at a speed of 1000 rpm for 5 min to obtain a transparent and uniform oil phase liquid;

[0079] S6 Emulsification: Cool the water phase in the main reaction kettle A to 48℃, and stir at a speed of 600 rpm; the oil phase liquid in the reaction kettle B is injected into the water phase through a pipeline shear emulsifier (10000 s -1 ) online to obtain an emulsion;

[0080] S7 Intelligent rheology and skin feel construction: Transfer the emulsion to a scraped paddle stirring kettle, and cool it to 38℃; add the pre-prepared organically modified clay pre-gel (sodium bentonite and the remaining capric acid triglyceride are stirred and dispersed at 3000 rpm for 12 min to prepare), and stir at a speed of 40 rpm for 20 min to make it uniformly dispersed; under the same stirring conditions, add boron nitride, and continue to stir for 30 min to ensure that the powder is fully wetted and dispersed without visible particles;

[0081] S8 Blending: Cool the system to 30℃, add cyclopentasiloxane, and stir at a speed of 30 rpm for 8 min to make it uniformly dispersed, and the skin care type hand sanitizer is obtained.

[0082] Example 4

[0083] The skin care type hand sanitizer of this example is composed of the following components in mass percentage: glycerol monostearate 1%, glyceryl stearate 1%, glycerol 2%, p-chloro-m-cresol 0.5%, ε-polylysine 0.1%, hydrophobically modified hydroxyethyl cellulose 0.5%, acrylates 0.075%, C10-30 alkyl acrylate crosspolymer Pemulen TR-2 0.025%, magnesium aluminum silicate 0.05%, stearalkonium bentonite 0.2%, silica 0.5%, cyclopentasiloxane 1%, potassium hydroxide 1%, and the rest is deionized water.

[0084] The preparation method of the skin care type hand sanitizer of this example includes the following steps:

[0085] S1 Water phase base preparation: add 60wt.% of deionized water in the total water amount to the main reaction kettle A and stir at a speed of 500 rpm; add acrylates and C10-30 alkyl acrylate crosspolymer Pemulen TR-2 to the main reaction kettle A and stir for 10 min to make them fully wet and dispersed without fisheyes or lumps;

[0086] S2 Instantaneous activation thickening: prepare an aqueous solution of potassium hydroxide with the remaining deionized water and add it dropwise to the main reaction kettle A within 2 min to adjust the pH of the system to 6.2, and the system becomes a gel base within 60 s;

[0087] S3 Dissolution of main components: add hydrophobically modified hydroxyethyl cellulose to the gel base and stir at a speed of 600 rpm for 20 min to dissolve; then add glycerol, p-chloro-m-cresol, and ε-polylysine in sequence and stir at a speed of 600 rpm for 25 min in total;

[0088] S4 Rheology adjustment: add magnesium aluminum silicate and stir at a speed of 900 rpm for 15 min to make it fully hydrated and gelled to obtain the water phase;

[0089] S5 Oil phase preparation: add glycerol monostearate and 2% of glyceryl stearate in the total mass of glyceryl stearate to the reaction kettle B, use the stepwise heating method, first heat it to 60℃, keep stirring for 3 min, then continue to heat to 76℃, and stir at a speed of 1200 rpm for 4 min to obtain a transparent and uniform oil phase liquid;

[0090] S6 Emulsification: cool the water phase in the main reaction kettle A to 42℃ and stir at a speed of 600 rpm; the oil phase liquid in the reaction kettle B is injected into the water phase online through a pipeline shear emulsifier (10000 s -1 ) to obtain an emulsion;

[0091] S7 Intelligent rheology and skin feel construction: transfer the emulsion to the scraped paddle stirred tank, cool to 37℃; add the pre-prepared organically modified clay pre-gel (sodium bentonite prepared by stirring the remaining glycerol stearate at 3000 rpm for 10 min), and stir at a speed of 50 rpm for 18 min to make it uniformly dispersed; under the same stirring conditions, add silica, continue to stir for 25 min to ensure that the powder is completely wetted and dispersed, and there are no visible particles;

[0092] S8 Harmonization: cool the system to 28℃, add cyclopentasiloxane, stir at a speed of 40 rpm for 7 min to make it uniformly dispersed, and the skin care type hand sanitizer is obtained.

[0093] Example 5

[0094] The skin care type hand sanitizer of this example is composed of the following components in mass percentage: polyglycerol-3 diisostearate 5%, isopropyl myristate 5%, squalane 3%, PEG-7 glyceryl cocoate 3%, allantoin 0.2%, didecyldimethylammonium chloride 3%, ε-polylysine 0.5%, hydrophobically modified hydroxyethyl cellulose 2.5%, acrylate 0.4%, C10-30 alkyl acrylate crosspolymer Pemulen TR-2 0.4%, magnesium aluminum silicate 0.3%, sodium bentonite 1%, boron nitride 2%, cyclopentasiloxane 3%, triethanolamine 5%, and the rest is deionized water.

[0095] The preparation method of the skin care type hand sanitizer of this example includes the following steps:

[0096] S1 Preparation of water phase base: add 70% of the total water amount of deionized water to the main reaction kettle A and stir at a speed of 550 rpm; add acrylate and C10-30 alkyl acrylate crosspolymer Pemulen TR-2 to the main reaction kettle A and stir for 12 min to make it fully wet and dispersed without fish eyes or lumps;

[0097] S2 Instantaneous activation thickening: prepare an aqueous solution of triethanolamine with the remaining deionized water and add it to the main reaction kettle A within 2 min to adjust the pH of the system to 6.8, and the system becomes a gel base within 120 s;

[0098] S3 Dissolution of main ingredients: add hydrophobically modified hydroxyethyl cellulose to the gel base and stir at a speed of 650 rpm for 25 min to dissolve; then add squalane, PEG-7 glyceryl cocoate, allantoin, didecyldimethylammonium chloride, and ε-polylysine in turn, and stir at a speed of 650 rpm for a total of 25 min;

[0099] S4 rheology adjustment: add sodium magnesium silicate, stir at 1000 rpm for 18 min to make it fully hydrated and gelled, to obtain an aqueous phase;

[0100] S5 oil phase preparation: add polyglyceryl-3 diisostearate and 0.5% of the total mass of isopropyl myristate into reaction kettle B, use the stepwise heating method, first heat to 62℃, keep stirring for 7 min, then continue to heat to 80℃, and stir at 1500 rpm for 5 min, to obtain a transparent and uniform oil phase liquid;

[0101] S6 emulsification: cool the aqueous phase in main reaction kettle A to 48℃, and stir at 800 rpm; the oil phase liquid in reaction kettle B is injected into the aqueous phase through a pipeline shear emulsifier (15000 s -1 ) online, to obtain an emulsion;

[0102] S7 intelligent rheology and skin feel construction: transfer the emulsion to a scraped paddle stirring kettle, cool to 38℃; add the pre-prepared organically modified clay pre-gel (sodium chitosan bentonite and the remaining isopropyl myristate are dispersed by stirring at 4000 rpm for 12 min to prepare), scrape wall stirring at 50 rpm for 20 min, to make it uniformly dispersed; under the same stirring conditions, add boron nitride, continue to stir for 30 min, to ensure that the powder is completely wetted and dispersed, without visible particles;

[0103] S8 blending: cool the system to 28℃, add cyclopentasiloxane, stir at 50 rpm for 8 min, to make it uniformly dispersed, to obtain a skin care type hand sanitizer.

[0104] Comparative Example 1

[0105] The difference from Example 1 is that the skin care type hand sanitizer uses water instead of equal amount of acrylates and C10-30 alkanol acrylate crosspolymer Pemulen TR-2.

[0106] Comparative Example 2

[0107] The difference from Example 1 is that the skin care type hand sanitizer uses acrylates instead of equal amount of C10-30 alkanol acrylate crosspolymer Pemulen TR-2.

[0108] Comparative Example 3

[0109] The difference from Example 1 is that the skin care type hand sanitizer uses C10-30 alkanol acrylate crosspolymer Pemulen TR-2 instead of equal amount of acrylates.

[0110] Comparative Example 4

[0111] The difference from Example 1 is that water is used to replace the equivalent amount of benzalkonium chloride bentonite in the skin care type hand sanitizer.

[0112] Comparative Example 5

[0113] The difference from Example 1 is that water is used to replace the equivalent amount of sodium magnesium silicate in the skin care type hand sanitizer.

[0114] Comparative Example 6

[0115] The difference from Example 1 is that benzalkonium chloride is used to replace the equivalent amount of ε-polylysine in the skin care type hand sanitizer.

[0116] Comparative Example 7

[0117] The difference from Example 1 is that in step S5, a one-step heating method is used to replace the step-by-step heating method, and the reaction kettle B is directly heated to 78°C.

[0118] Comparative Example 8

[0119] The difference from Example 1 is that in step S6, the oil phase liquid in reaction kettle B is directly added to the water phase without shearing through the pipeline type shear emulsifier.

[0120] The hand sanitizers prepared in Examples 1-5 and Comparative Examples 1-8 were tested for bactericidal effect and field test, and the test was carried out according to GB 27950-2020 General Requirements for Hand Sanitizers and WS / T 10009 Disinfection Product Detection Method. The test results are shown in Table 1:

[0121] Table 1 Bactericidal effect test and field test results of hand sanitizers prepared in Examples 1-5 and Comparative Examples 1-8

[0122]

[0123] The production efficiency and product quality of Examples 1-5 and Comparative Examples 1-8 are shown in Table 2:

[0124] Table 2 Production efficiency and product quality of Examples 1-5 and Comparative Examples 1-8

[0125]

[0126] As can be seen from Table 1, the hand sanitizer products of Examples 1-5 and Comparative Examples 1-8 have excellent killing effect on bacteria. However, the killing logarithm value of Pseudomonas aeruginosa and Candida albicans in Comparative Example 6 without adding bactericidal component ε-polylysine is significantly lower than that of Example 1, which proves that ε-polylysine has a key synergistic effect on anti-fungus and gram-negative bacteria when compounded with other cationic bactericides.

[0127] As can be seen from Table 2, Examples 1-5 achieve instant thickening (<2 min) and no curing. Comparative Examples 2-3 use single thickening agent, which results in long thickening time and curing, proving that the use of specific compounded synergistic thickening agent in the present application is the core of achieving fast production. In addition, it is also observed that the products of Comparative Example 5 without adding rheological modifier, Comparative Example 7 using one-step heating method and Comparative Example 8 without shear injection all appear to be layered, proving that the rheological modifier in the present application, the step heating method for emulsification and the shear injection process are indispensable for forming stable emulsion structure.

[0128] As can also be seen from Table 2, the products of Examples 1-5 have low shear viscosity and excellent smoothness. However, Comparative Example 4 does not add selamine bentonite, which results in poor dispersion of boron nitride and makes the product have poor skin feel and high shear viscosity. Comparative Examples 2, 3 and 5 have poor rheological system construction, which results in high shear viscosity and strong sticky feeling of the product, proving that the synergy of each component in the intelligent rheological system of the present application is the key to achieving the "static thickening and dynamic thinning" skin feel.

[0129] In addition, Examples 1-5 use pipeline shear emulsifier when injecting the oil phase liquid into the water phase, which makes the particle size of the final product be 1-10 μm, and the product is relatively delicate. However, Comparative Example 8 does not use pipeline shear emulsifier, which results in the particle size of the product being 50-100 μm, and the product is rough with obvious particles.

Claims

1. A skin-care type hand sanitizer, characterized in that, Composed of the following components by mass percentage composition: Emulsifier: 1-5%; Oil phase: 1-5%; Skincare ingredients: 2-8%; Bactericidal component: 0.6-3.5%; Improved film-forming agent: 0.5-2.5%; Synergistic thickener: 0.1-0.8%; Rheology modifier: 0.05-0.3%; Organic modified clay: 0.2-1%; Skin feel adjustment powder: 0.5-2%; Volatile silicone oil: 1-3%; pH adjuster: 1-5%; The rest is water; The bactericidal component is 0.5-3% of one of chlorhexidine gluconate, benzalkonium chloride, benzalkonium bromide, didecyl dimethyl ammonium chloride, and p-chloro-meta-xylenol, along with 0.1-0.5% of ε-polylysine; the synergistic thickener is a cross-linked polymer of acrylate and acrylic (ester) / C10-30 alkanol acrylate in a mass ratio of (1-4):1; the rheology modifier is sodium magnesium silicate; and the organic modified clay is silachlor bentonite. The preparation method of skin-care hand sanitizer includes the following steps: Preparation of S1 aqueous phase base material: Add water accounting for 60-70 wt.% of the total water volume to the main reactor A and start stirring; add the synergistic thickener to the main reactor A and continue stirring to fully wet and disperse it; S2 instantaneous activation thickening: Prepare an aqueous solution of pH adjuster with the remaining water and add it dropwise to the system within 2-4 min to adjust the pH of the system to 6.2-6.

8. The system will become a gel base within 60-120 s. S3 Dissolving Main Ingredients: Add the improved film-forming agent to the gel base and stir until it is completely dissolved; then add the skin care ingredients and antibacterial ingredients in sequence and stir until completely dissolved. S4 Rheology Modification: Add rheology modifier and stir to fully hydrate and gel, obtaining an aqueous phase; S5 oil phase preparation: Add emulsifier and 0.5-3% of oil phase by mass into reactor B. Use a step heating method to first heat it to 58-62℃, keep it at this temperature and stir for 3-7 minutes, then continue heating to 76-80℃, and stir at 1000-1500 rpm for 3-5 minutes until the system is a transparent and homogeneous oil phase liquid. S6 Emulsification: Cool the aqueous phase in the main reactor A to 42-48℃ and stir; inject the oil phase liquid in reactor B into the aqueous phase online through a pipeline shear emulsifier to obtain an emulsion; S7 Intelligent Rheology and Skin Feel Construction: Transfer the emulsion to a scraped-plate stirred tank and cool it to 36-38℃; add the pre-prepared organic modified clay pregel, which is made by stirring and dispersing organic modified clay and the remaining oil phase; then stir at 40-60 rpm for 15-20 min, and under the same stirring conditions, add skin feel adjustment powder and continue stirring for 20-30 min; S8 Mixing: Cool the system to 26-30℃, add volatile silicone oil, and stir to disperse it evenly to obtain a skin-care hand sanitizer.

2. The skin-care type hand sanitizer as described in claim 1, characterized in that, The emulsifier is glyceryl monostearate, polyglycerol-3 diisostearate, or lanolin alcohol.

3. The skin-care type hand sanitizer as described in claim 1, characterized in that, The oil phase is glyceryl stearate, triglyceride caprylate, or isopropyl myristate.

4. The skin-care type hand sanitizer as described in claim 1, characterized in that, The skincare ingredients are one or more of glycerin, sodium hyaluronate, squalane, PEG-7 glyceryl cocoate, and allantoin.

5. The skin-care type hand sanitizer as described in claim 1, characterized in that, The improved film-forming agent is hydrophobically modified hydroxyethyl cellulose.

6. The skin-care type hand sanitizer as described in claim 1, characterized in that, The skin-feel conditioning powder is boron nitride or silica; the volatile silicone oil is cyclopentamethoxysiloxane; and the acid-base regulator is sodium hydroxide, potassium hydroxide, or triethanolamine.

7. The skin-care type hand sanitizer as described in claim 1, characterized in that, In step S1, the stirring speed is 450-550 rpm, and stirring continues for 8-12 minutes after adding the synergistic thickener.

8. The skin-care type hand sanitizer as described in claim 1, characterized in that, In step S3, the stirring speed is 550-650 rpm and the stirring time is 15-25 min; in step S4, the stirring speed is 800-1000 rpm and the stirring time is 12-18 min.

9. The skin-care type hand sanitizer as described in claim 1, characterized in that, In step S6, the stirring speed is 600-800 rpm and the shear rate is 10000-15000 s. -1 In step S7, the stirring speed is 3000-4000 rpm and the stirring time is 8-12 min; in step S8, the stirring speed is 30-50 rpm and the stirring time is 5-8 min.

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