Hangover alleviating tableted candy rich in dendrobium officinale polysaccharide and preparation method of hangover alleviating tableted candy

Abstract

The invention discloses hangover-alleviating tableted candies rich in dendrobium officinale polysaccharides and a preparation method of the hangover-alleviating tableted candies. Comprising the following components in parts by weight: 10 to 30 parts of dendrobium officinale polysaccharide, 0.5 to 8 parts of curcumin, 5 to 20 parts of puerarin, 2 to 10 parts of a hovenia dulcis thunb extract, 10 to 30 parts of a hawthorn extract, 1 to 10 parts of gamma-aminobutyric acid, 1 to 8 parts of maltodextrin, 10 to 50 parts of sorbitol, 2 to 10 parts of microcrystalline cellulose, 0.2 to 1.6 parts of citric acid and 1 to 8 parts of magnesium stearate. According to the alcoholism-relieving tableted candy rich in dendrobium officinale polysaccharide and the preparation method of the alcoholism-relieving tableted candy, various components are matched with one another, uncomfortable symptoms after drinking can be effectively relieved, natural raw materials are adopted, and safety is high.

Description

Technical Field

[0001] The invention relates to the technical field of hangover relief products, in particular to a hangover relief tablet candy rich in dendrobium officinale polysaccharide and a preparation method thereof. Background Art

[0002] The state of intoxication caused by excessive drinking not only seriously affects personal health but also leads to serious social problems. According to the World Health Organization (WHO), approximately 3 million people die each year from alcohol-related diseases and injuries, accounting for 5.3% of the global death toll. Intoxication can lead to traffic accidents and violent behavior; it can also cause health risks such as liver damage, cardiovascular disease, cancer, nervous system damage, and mental health problems. Although there are many hangover remedies on the market, most have limited effectiveness or contain chemical ingredients, and long-term use may have adverse effects on the body, such as kidney damage. In addition, many existing hangover remedies often lack sufficient scientific evidence to support their claimed effects, and in actual use, they have shown problems such as slow hangover relief and ineffective relief of discomfort symptoms.

[0003] Dendrobium officinale, a traditional medicinal and edible resource, is known in China as "the first of the nine immortal herbs of China." Modern research indicates that its polysaccharides possess multiple biological activities, including antioxidant, immune-enhancing, anti-inflammatory, and hepatoprotective properties, showing potential application in alleviating alcoholism. However, there are currently few examples of effective hangover remedies developed using Dendrobium officinale polysaccharides as a primary ingredient. By combining these natural ingredients in a scientifically formulated formulation, not only can the product's hangover-relieving effects be enhanced, but the potential for kidney damage from chemical ingredients can also be mitigated, providing consumers with a healthier alternative.

[0004] Although Dendrobium officinale is believed to have certain liver-protecting, antioxidant and immunomodulatory effects due to its "medicine and food" identity and multiple active ingredients such as polysaccharides, alkaloids, amino acids, and is expected to relieve alcohol poisoning, a large number of experiments and clinical studies have shown that if only relying on a single Dendrobium officinale raw material (whether raw powder, decoction or purified polysaccharide) for hangover relief, its onset speed, intensity of action and comprehensiveness of symptom relief have obvious shortcomings, and it cannot quickly, comprehensively and reliably relieve the discomfort after drinking. Summary of the Invention

[0005] The purpose of the present invention is to provide a hangover-relieving tablet candy rich in Dendrobium officinale polysaccharide and a preparation method thereof. The candy adopts multiple components to cooperate with each other, can effectively help relieve the discomfort symptoms after drinking, and uses natural raw materials, so it is highly safe.

[0006] The present invention discloses a hangover-relieving tablet candy rich in Dendrobium officinale polysaccharide and a preparation method thereof, and the technical solution adopted is: A hangover-relieving compressed candy rich in dendrobium officinale polysaccharide comprises the following components in parts by weight: 10-30 parts of dendrobium officinale polysaccharide, 0.5-8 parts of curcumin, 5-20 parts of puerarin, 2-10 parts of hovenia dulcis fruit extract, 10-30 parts of hawthorn extract, 1-10 parts of gamma-aminobutyric acid, 1-8 parts of maltodextrin, 10-50 parts of sorbitol, 2-10 parts of microcrystalline cellulose, 0.2-1.6 parts of citric acid, and 1-8 parts of magnesium stearate.

[0007] As a preferred embodiment, the ratio of the Hovenia dulcis fruit extract is 30 parts of raw materials extracted and concentrated into 1 part of extract.

[0008] As a preferred embodiment, the preparation method of the Dendrobium officinale polysaccharide comprises the following steps: S1: Add 10 times the volume of pure water to fresh Dendrobium officinale, beat it into pulp, and then add cellulase for enzymatic hydrolysis. The temperature is controlled at 40-50°C to prepare Dendrobium officinale slurry. S2: centrifuging the Dendrobium officinale slurry, collecting the supernatant, and then vacuum concentrating; S3: adding 4 times the volume of anhydrous ethanol to the concentrate, stirring, letting it stand for 24 hours, and centrifuging to obtain a precipitate; S4: re-dissolving the precipitate in water, evaporating the ethanol and freeze-drying the mixture to obtain Dendrobium officinale polysaccharide.

[0009] As a preferred solution, in step S4, the precipitate is freeze-dried to a moisture content of ≤5%, and then pulverized to 125-180 mesh size using a jet mill.

[0010] A method for preparing the above-mentioned alcohol-relieving tablet candy rich in Dendrobium officinale polysaccharide comprises the following steps: mixing Dendrobium officinale polysaccharide, curcumin, puerarin, Hovenia dulcis fruit extract, Crataegus pinnatifida extract, gamma-aminobutyric acid, maltodextrin, sorbitol, microcrystalline cellulose, citric acid and magnesium stearate to obtain a mixture; The mixture is placed in a tablet press to obtain the hangover-relieving tablet candy.

[0011] As a preferred embodiment, the specification of the compressed candy is 0.2g-2.0g / tablet.

[0012] As a preferred embodiment, the Dendrobium officinale polysaccharide, curcumin, puerarin, Hovenia dulcis fruit extract, Crataegus pinnatifida extract, γ-aminobutyric acid, maltodextrin, sorbitol, and citric acid are first mixed to prepare a soft material; Then take the above soft material, sieve and granulate it, dry it at 65-75℃, and sieve it again to make granules; Magnesium stearate and microcrystalline cellulose were added to the granules of the mixed preparation and mixed thoroughly.

[0013] The invention discloses a hangover-relieving compressed candy rich in dendrobium officinale polysaccharide, which has the beneficial effects of increasing alcohol dehydrogenase activity, reducing alcohol damage to liver and kidney tissues, having no side effects on the human body, being convenient to carry, and being suitable for all ages; the components in the formula act synergistically, dendrobium officinale powder and ingredients such as puerarin and hovenia dulcis fruit extract jointly promote alcohol metabolism and clearance, curcumin and hawthorn extract exert anti-inflammatory and liver-protecting effects, gamma-aminobutyric acid regulates the nervous state, and auxiliary materials such as maltodextrin, sorbitol, and microcrystalline cellulose are used in combination to ensure that the compressed candy has good taste, stability, and hangover-relieving effect. Through scientific proportioning, the candy not only has significant hangover-relieving and liver-protecting effects, but also can improve discomfort symptoms after drinking, and is suitable for daily consumption before and after drinking. BRIEF DESCRIPTION OF THE DRAWINGS

[0014] Figure 1 The present invention provides an embodiment of a hangover-relieving tablet candy rich in Dendrobium officinale polysaccharide and an alcohol dehydrogenase activity diagram of a comparative example.

[0015] Figure 2 The present invention provides a graph showing the activation rate of alcohol dehydrogenase in an embodiment of a hangover-relieving tablet candy rich in Dendrobium officinale polysaccharide and a comparative example.

[0016] Figure 3 The present invention provides an embodiment of a hangover-relieving tablet candy rich in Dendrobium officinale polysaccharide and an acetaldehyde dehydrogenase activity diagram of a comparative example.

[0017] Figure 4 This is a graph of acetaldehyde dehydrogenase activation rate of a hangover-relieving compressed candy rich in Dendrobium officinale polysaccharide of the present invention. DETAILED DESCRIPTION

[0018] The present invention will be further described and explained below in conjunction with specific embodiments and accompanying drawings: Example 1: A method for preparing alcohol-relieving tablet candy rich in Dendrobium officinale polysaccharide comprises the following steps: Efficient extraction and preparation of Dendrobium officinale polysaccharides: Fresh Dendrobium officinale raw material is cryogenically crushed, added with 10 times its mass of water, and 500-4000 U / mL of cellulase. Extraction is carried out in a 40°C water bath for 0.5-2 hours. Centrifugation is performed, and the supernatant is collected and vacuum concentrated. Four times the volume of the concentrate is added with anhydrous ethanol, and precipitation is carried out for 24 hours. The supernatant is discarded to obtain a filter residue. The filter residue is dissolved in a small amount of water and freeze-dried to a moisture content of ≤5%. The residue is then ground into 150 mesh (particle size 100 ± 20 μm) using a jet mill. Preparation of mixed soft material: 20 parts of Dendrobium officinale polysaccharide prepared in step (1), 2.25 parts of curcumin, 10 parts of puerarin, 4 parts of Hovenia dulcis fruit extract (ratio: 30:1), 15 parts of hawthorn extract, 5 parts of γ-aminobutyric acid, 8 parts of maltodextrin, 10 parts of sorbitol, and 1.2 parts of citric acid were mixed to prepare a soft material; Preparation of granules of mixed preparation: take the above soft material and sieve through 16 mesh sieve, dry it at 70℃ for 7h, and then sieve through 16 mesh sieve to make granules; 2% by weight of magnesium stearate and 6% by weight of microcrystalline cellulose were added to the granules of the mixed preparation, mixed thoroughly, and tableted to obtain the desired composite hangover-relieving tablet candy, which was packaged with a specification of 0.5 g / tablet.

[0019] Example 2: A method for preparing alcohol-relieving tablet candy rich in Dendrobium officinale polysaccharide comprises the following steps: Efficient extraction and preparation of Dendrobium officinale polysaccharides: Fresh Dendrobium officinale raw material is cryogenically crushed, added with 10 times its mass of water, and cellulase at 500-4000 U / mL. Extraction is carried out in a 40°C water bath for 0.5-2 hours. Centrifugation is performed, and the supernatant is collected and vacuum concentrated. Four times the volume of the concentrate is added with anhydrous ethanol, and precipitation is carried out for 24 hours. The supernatant is discarded to obtain a filter residue. The filter residue is dissolved in a small amount of water and freeze-dried to a moisture content of ≤5%. The residue is then ground into 150 mesh (particle size 100 ± 20 μm) using a jet mill. Preparation of mixed soft material: 5 parts of Dendrobium officinale polysaccharide prepared in step (1), 0.5 parts of curcumin, 5 parts of puerarin, 4 parts of Hovenia dulcis fruit extract (ratio: 30:1), 5 parts of hawthorn extract, 3 parts of γ-aminobutyric acid, 12 parts of maltodextrin, 18 parts of sorbitol, and 1.2 parts of citric acid were mixed to prepare a soft material; Preparation of granules of mixed preparation: take the above soft material and sieve through 16 mesh sieve, dry it at 70℃ for 7h, and then sieve through 16 mesh sieve to make granules; 2% by weight of magnesium stearate and 6% by weight of microcrystalline cellulose were added to the granules of the mixed preparation, mixed thoroughly, and tableted to obtain the desired composite hangover-relieving tablet candy, which was packaged with a specification of 0.5 g / tablet.

[0020] Example 3: A method for preparing alcohol-relieving tablet candy rich in Dendrobium officinale polysaccharide comprises the following steps: Efficient extraction and preparation of Dendrobium officinale polysaccharides: Fresh Dendrobium officinale raw material is cryogenically crushed, added with 10 times its mass of water, and cellulase at 500-4000 U / mL. Extraction is carried out in a 40°C water bath for 0.5-2 hours. Centrifugation is performed, and the supernatant is collected and vacuum concentrated. Four times the volume of the concentrate is added with anhydrous ethanol, and precipitation is carried out for 24 hours. The supernatant is discarded to obtain a filter residue. The filter residue is dissolved in a small amount of water and freeze-dried to a moisture content of ≤5%. The residue is then ground into 150 mesh (particle size 100 ± 20 μm) using a jet mill. Preparation of mixed soft material: 20 parts of Dendrobium officinale polysaccharide prepared in step (1), 0.5 parts of curcumin, 5 parts of puerarin, 2 parts of Hovenia dulcis fruit extract (ratio: 30:1), 15 parts of hawthorn extract, 3 parts of γ-aminobutyric acid, 10 parts of maltodextrin, 20 parts of sorbitol, and 1.2 parts of citric acid are taken by weight and mixed to prepare a soft material; Preparation of granules of mixed preparation: take the above soft material and sieve through 16 mesh sieve, dry it at 70℃ for 7h, and then sieve through 16 mesh sieve to make granules; 2% by weight of magnesium stearate and 8% by weight of microcrystalline cellulose were added to the granules of the mixed preparation, mixed thoroughly, and tableted to obtain the desired composite hangover-relieving tablet candy, which was packaged with a specification of 0.5 g / tablet.

[0021] Comparative Example 1: A method for preparing a hangover-relieving tablet candy that does not contain Dendrobium officinale polysaccharide comprises the following steps: Preparation of mixed soft material: 0.5 parts of curcumin, 5 parts of puerarin, 2 parts of Hovenia dulcis fruit extract (ratio: 30:1), 15 parts of hawthorn extract, 3 parts of γ-aminobutyric acid, 10 parts of maltodextrin, 20 parts of sorbitol, and 1.2 parts of citric acid are mixed to prepare a soft material; Preparation of granules of mixed preparation: take the above soft material and sieve through 16 mesh sieve, dry it at 70℃ for 7h, and then sieve through 16 mesh sieve to make granules; 2% by weight of magnesium stearate and 8% by weight of microcrystalline cellulose were added to the granules of the mixed preparation, mixed thoroughly, and tableted to obtain the desired composite hangover-relieving tablet candy, which was packaged with a specification of 0.5 g / tablet.

[0022] Comparative Example 2: A method for preparing a hangover-relieving tablet candy containing only Dendrobium officinale polysaccharide comprises the following steps: Efficient extraction and preparation of Dendrobium officinale polysaccharides: Fresh Dendrobium officinale raw material is cryogenically crushed, added with 10 times its mass of water, and cellulase at 500-4000 U / mL. Extraction is carried out in a 40°C water bath for 0.5-2 hours. Centrifugation is performed, and the supernatant is collected and vacuum concentrated. Four times the volume of the concentrate is added with anhydrous ethanol, and precipitation is carried out for 24 hours. The supernatant is discarded to obtain a filter residue. The filter residue is dissolved in a small amount of water and freeze-dried to a moisture content of ≤5%. The residue is then ground into 150 mesh (particle size 100 ± 20 μm) using a jet mill. Preparation of mixed soft material: 20 parts of the Dendrobium officinale polysaccharide prepared in step (1), 10 parts of maltodextrin, 20 parts of sorbitol, and 1.2 parts of citric acid are mixed to prepare a soft material; Preparation of granules of mixed preparation: take the above soft material and sieve through 16 mesh sieve, dry it at 70℃ for 7h, and then sieve through 16 mesh sieve to make granules; 2% by weight of magnesium stearate and 8% by weight of microcrystalline cellulose were added to the granules of the mixed preparation, mixed thoroughly, and tableted to obtain the desired composite hangover-relieving tablet candy, which was packaged with a specification of 0.5 g / tablet.

[0023] The beneficial effects of the present invention are demonstrated by two sets of experiments below: In vitro alcohol dehydrogenase activity activation test: Experimental reagents: Alcohol dehydrogenase (batch number: S10111-15KU) and acetaldehyde dehydrogenase (batch number: S10195-25U) were purchased from Shanghai Yuanye Biotechnology Co., Ltd., alcohol dehydrogenase kit (A083-2-1) was purchased from Nanjing Jiancheng Bioengineering Research Institute, and oxidized coenzyme I was purchased from Beijing Coolbo Technology Co., Ltd.

[0024] Experimental group: Examples 1-3 and Comparative Examples 1-2 shown in the present invention.

[0025] Control group: JUZT sugar-free green tea kudzu root lozenges (candy), Herbal Future (Hangzhou) Health Industry Co., Ltd.

[0026] Experimental Procedure: The activities of alcohol dehydrogenase and aldehyde dehydrogenase were determined using a Valle-Hoch assay. To a stoppered test tube, add 1.5 mL of sodium pyrophosphate buffer, 1.0 mL of NAD+, and 0.5 mL of ethanol. Add 0.1 mL of the aqueous solutions of Examples 1-3, Comparative Examples 1-2, and the control compressed candy at the same mass concentrations, respectively. Mix and incubate at 37°C with a lid on for 5 minutes. Immediately add 0.1 mL of alcohol dehydrogenase or aldehyde dehydrogenase (0.25 U / mL) to the stoppered test tube. Replace the enzyme solution with distilled water in the control tube. Shake well, incubate at 37°C for 5 minutes, and measure absorbance at 340 nm. Read the absorbance every 30 seconds for 5 minutes. Use the control tube as the zero point, and calculate the average absorbance per minute (ΔA / min).

[0027] △A / min×× × × Activation rate / %=( ) / ×100% In formula (2), U1 and U0 are the enzyme activities of the experimental group and the control group, respectively.

[0028] The results of alcohol dehydrogenase activity and activation rate were as follows: Figure 1 and 2As shown, the results of Comparative Examples 1 and 2 of the present invention show that the compressed candies made from Dendrobium officinale polysaccharide and the compound curcumin, puerarin, Hovenia dulcis fruit extract, hawthorn extract, and γ-aminobutyric acid all have certain alcohol dehydrogenase activation activity. When the two are combined, the effect is even better. For example, Example 1, which combines Dendrobium officinale polysaccharide, curcumin, puerarin, Hovenia dulcis fruit extract, hawthorn extract, and γ-aminobutyric acid, has the highest in vitro alcohol dehydrogenase activation activity, and the effect is better than the commercial JUZT sugar-free green tea kudzu lozenges.

[0029] The results of aldehyde dehydrogenase activity and activation rate were as follows: Figure 3 and 4 As shown, the results of Comparative Examples 1 and 2 of the present invention show that the compressed candies made from Dendrobium officinale polysaccharide and the compound curcumin, puerarin, Hovenia dulcis fruit extract, hawthorn extract, and γ-aminobutyric acid all have certain aldehyde dehydrogenase activation activity. When the two are compounded, the effect is even better. For example, the in vitro aldehyde dehydrogenase activation activities of Examples 1-3, which are compounded with Dendrobium officinale polysaccharide, curcumin, puerarin, Hovenia dulcis fruit extract, hawthorn extract, and γ-aminobutyric acid, are all higher than those of Comparative Examples 1 and 2. In particular, Example 1 has the highest activation activity, and the effect is better than the commercial JUZT sugar-free green tea kudzu lozenges.

[0030] In summary, Dendrobium officinale polysaccharide combined with the compound curcumin, puerarin, Hovenia dulcis extract, Crataegus pinnatifida extract and γ-aminobutyric acid can significantly activate the activity of acetaldehyde dehydrogenase and alcohol dehydrogenase, achieving the effect of anti-drunkenness.

[0031] Sensory evaluation: The prepared compressed candies were sealed, nitrogen-filled, and stored at room temperature for two months. Twenty volunteers were then recruited to evaluate Examples 1-3 and Comparative Examples 1-2. The sensory evaluation of the compressed candies was conducted according to the method described in SB / T 10347-2017. The scoring criteria are shown in Table 1. The specific test results (average values) are shown in Table 2.

[0032] Table 1: Sensory indicators Table 2: Test results Combined with the test results in Table 2, it can be seen that the compressed candies prepared by the present invention have a complete shape, a firm and non-loose structure, a tight and smooth cross-section without impurities, and excellent taste and smell scores, and have a good edible effect.

[0033] The present invention provides a kind of alcohol-relieving tablet candy rich in Dendrobium officinale polysaccharide and its preparation method, the tablet candy takes Dendrobium officinale polysaccharide as core active ingredient, supplemented with curcumin, puerarin, Hovenia dulcis extract, hawthorn extract, gamma-aminobutyric acid and other natural active ingredients, through scientific proportioning and synergistic effect, significantly improves the activity of alcohol dehydrogenase and acetaldehyde dehydrogenase, accelerates alcohol metabolism, and effectively relieves the discomfort symptoms after drunkenness, such as dizziness, nausea, fatigue, anxiety, etc. At the same time, the tablet candy uses natural raw materials, has high safety, has no obvious side effects when taken for a long time, and has good taste, stability and bioavailability, is suitable for daily taking before and after drinking, and has broad market application prospects. By implementing the present invention, not only the high-value utilization of Dendrobium officinale polysaccharide is achieved, but also a convenient, healthy and effective alcohol-relieving product is provided to consumers.

[0034] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit the scope of protection of the present invention. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solutions of the present invention may be modified or replaced by equivalents without departing from the essence and scope of the technical solutions of the present invention.

Claims

1. A hangover-relieving tablet candy rich in Dendrobium officinale polysaccharide, characterized in that: The invention comprises the following components in parts by weight: 10-30 parts of dendrobium officinale polysaccharide, 0.5-8 parts of curcumin, 5-20 parts of puerarin, 2-10 parts of hovenia dulcis fruit extract, 10-30 parts of hawthorn extract, 1-10 parts of gamma-aminobutyric acid, 1-8 parts of maltodextrin, 10-50 parts of sorbitol, 2-10 parts of microcrystalline cellulose, 0.2-1.6 parts of citric acid and 1-8 parts of magnesium stearate.

2. The alcohol-relieving tablet candy rich in Dendrobium officinale polysaccharide according to claim 1, characterized in that: The ratio of the Hovenia dulcis fruit extract is 30 parts of raw materials extracted and concentrated into 1 part of the extract.

3. The alcohol-relieving tablet candy rich in Dendrobium officinale polysaccharide according to claim 1, characterized in that: The preparation method of the Dendrobium officinale polysaccharide comprises the following steps: S1: Add 10 times the volume of pure water to fresh Dendrobium officinale, beat it into pulp, and then add cellulase for enzymatic hydrolysis. The temperature is controlled at 40-50°C to prepare Dendrobium officinale slurry. S2: centrifuging the Dendrobium officinale slurry, collecting the supernatant, and then vacuum concentrating; S3: adding 4 times the volume of anhydrous ethanol to the concentrate, stirring, letting it stand for 24 hours, and centrifuging to obtain a precipitate; S4: re-dissolving the precipitate in water, evaporating the ethanol and freeze-drying the mixture to obtain Dendrobium officinale polysaccharide.

4. The alcohol-relieving tablet candy rich in Dendrobium officinale polysaccharide according to claim 1, characterized in that: In step S4, the precipitate is freeze-dried to a moisture content of ≤5%, and then pulverized into 125-180 meshes using a jet mill.

5. A method for preparing the alcohol-relieving tablet candy rich in Dendrobium officinale polysaccharide according to any one of claims 1 to 4, characterized in that: The method comprises the following steps: mixing Dendrobium officinale polysaccharide, curcumin, puerarin, Hovenia dulcis fruit extract, Crataegus pinnatifida extract, gamma-aminobutyric acid, maltodextrin, sorbitol, microcrystalline cellulose, citric acid and magnesium stearate to obtain a mixture; The mixture is placed in a tablet press to obtain the hangover-relieving tablet candy.

6. The method for preparing a hangover-relieving tablet candy rich in Dendrobium officinale polysaccharide according to claim 1, characterized in that: The specification of the compressed candy is 0.2g-2.0g / tablet.

7. The method for preparing a hangover-relieving tablet candy rich in Dendrobium officinale polysaccharide according to claim 6, characterized in that: The method comprises mixing Dendrobium officinale polysaccharide, curcumin, puerarin, Hovenia dulcis fruit extract, hawthorn extract, γ-aminobutyric acid, maltodextrin, sorbitol, and citric acid to prepare a soft material; Then take the above soft material, sieve and granulate it, dry it at 65-75℃, and sieve it again to make granules; Magnesium stearate and microcrystalline cellulose were added to the granules of the mixed preparation and mixed thoroughly.

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