Traditional Chinese medicine composition for preventing and treating weaning stress of piglets as well as preparation method and application of traditional Chinese medicine composition

Abstract

The invention relates to the technical field of feed additives, in particular to a traditional Chinese medicine composition for preventing and treating weaning stress of piglets as well as a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 4-12 parts of acanthopanax, 3-9 parts of plantain herb, 3-9 parts of red peony root, 1-3 parts of elecampane and 1-3 parts of fructus aurantii. The traditional Chinese medicine composition can improve stress diarrhea caused by the fact that weaned piglets leave sows and do not adapt to new environments, and the stress reaction of the weaned piglets is relieved by taking the sedative and tranquillizing acanthopanax as a monarch drug; the herba plantaginis for dredging and regulating water channels is used as a ministerial drug to promote diuresis, expel toxins and improve viscera functions of piglets, and the radix paeoniae rubra is used as a ministerial drug to promote blood circulation, remove blood stasis and promote excretion of metabolites; the radix aucklandiae is used as an adjuvant drug, and the fructus aurantii is used as an envoy drug to promote qi and eliminate stagnation, promote gastrointestinal excretion of weaned piglets and improve gastrointestinal functions. Through scientific compatibility, the medicine effect can be synergistically enhanced, and the weaning stress reaction of piglets is relieved.

Description

Technical Field

[0001] The present invention relates to the technical field of feed additives, in particular to a traditional Chinese medicine composition for preventing and treating weaning stress in piglets, and a preparation method and application thereof. Background Art

[0002] Early weaning technology for piglets has been widely used in modern intensive and large-scale pig farming. However, after piglets are weaned and leave the sow, they are very likely to suffer from diarrhea caused by gastrointestinal discomfort due to the dual changes in environment and nutrition, which is called weaning stress. Weaning stress is caused by the superposition of multiple factors such as drastic changes in the environment, sudden changes in nutritional structure and psychological pressure. This stress state directly leads to immature development of the piglet's digestive system, temporary suppression of immune function, impaired intestinal barrier function and serious imbalance of intestinal flora. One of its core pathological manifestations is non-specific diarrhea, with high morbidity and mortality rates. It is a key factor causing growth retardation, increased feed-to-meat ratio and increased mortality rate in weaned piglets, bringing huge economic losses to the pig industry. Chinese medicine compositions have shown great potential due to their natural origin, multiple components, multiple targets and multifunctionality (such as antioxidant, anti-inflammatory, immune regulation, improvement of intestinal health, sedation and tranquilization). Therefore, there is an urgent need to develop a Chinese herbal compound feed additive based on the theory of Chinese veterinary syndrome differentiation, with precise formulation, clear mechanism, stable and reliable effect, and convenient for industrial production and application, so as to effectively prevent and control weaning stress diarrhea in piglets in a way that treats both the symptoms and the root causes, ensure the health of piglets, and improve the efficiency of pig farming. Summary of the Invention

[0003] The purpose of the present invention is to provide a traditional Chinese medicine composition for preventing and treating weaning stress in piglets, as well as its preparation method and application, so as to improve the stress reaction of weaned piglets caused by leaving the sow and not adapting to the new environment, and prevent and treat diarrhea caused by gastrointestinal discomfort.

[0004] In order to achieve the above-mentioned object of the invention, the present invention provides the following technical solutions:

[0005] The invention provides a traditional Chinese medicine composition comprising the following raw materials in parts by weight: 4-12 parts of acanthopanax senticosus, 3-9 parts of plantain, 3-9 parts of red peony root, 1-3 parts of costus root and 1-3 parts of fructus aurantii.

[0006] Optionally, the Chinese medicine composition comprises the following raw materials in parts by weight: 12 parts of Acanthopanax senticosus, 9 parts of Plantago, 9 parts of Red Peony Root, 3 parts of Costus Root and 3 parts of Citrus Aurantii Immaturus.

[0007] Optionally, the Chinese medicine composition comprises the following raw materials in parts by weight: 8 parts of Acanthopanax senticosus, 6 parts of Plantago, 6 parts of Red Peony Root, 2 parts of Costus Root and 2 parts of Citrus Aurantii Immaturus.

[0008] Optionally, the Chinese medicine composition comprises the following raw materials in parts by weight: 4 parts of Acanthopanax senticosus, 3 parts of Plantago, 3 parts of Red Peony Root, 1 part of Costus Root and 1 part of Citrus aurantium.

[0009] The present invention also provides a method for preparing the above-mentioned Chinese medicine composition, which is characterized by comprising the following steps:

[0010] Acanthopanax senticosus, Plantago, Red Peony Root, Costus Root and Fructus Aurantii Immaturus are mixed and crushed to obtain a traditional Chinese medicine composition.

[0011] Optionally, the particle size of the traditional Chinese medicine composition is 150-200 mesh.

[0012] The present invention also provides the use of the above-mentioned traditional Chinese medicine composition in preparing feed for preventing and treating weaning stress in piglets.

[0013] Compared with the prior art, the present invention has the following beneficial effects:

[0014] The present invention provides a traditional Chinese medicine composition that can effectively improve stress reactions such as diarrhea and decreased feed intake in piglets after weaning. The Acanthopanax senticosus in the traditional Chinese medicine composition has a calming and soothing effect, and improves intestinal flora; Plantago asiatica has a diuretic and detoxifying effect, promotes the excretion of metabolic waste in piglets, and prevents and treats the retention of metabolic waste in the body; Red Peony Root promotes blood circulation and removes blood stasis, and promotes the excretion of metabolites; Costus Root and Citrus Aurantii Immaturus regulate qi and eliminate stagnation, and promote excretion function. The five traditional Chinese medicines are all traditional Chinese medicines with medicinal and edible properties, and have no toxic side effects. The traditional Chinese medicine composition composed of the five traditional Chinese medicines can improve intestinal microflora, promote gastrointestinal excretion function, accelerate the excretion of metabolic waste in the body, correct the imbalance of intestinal flora after weaning in piglets, and the stress reactions of diarrhea and decreased feed intake caused by gastrointestinal dysfunction in piglets after weaning. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 The present invention is a flow chart of the preparation process of feed containing a Chinese medicine composition;

[0016] Figure 2 Alpha diversity of fecal microbiota, including A: Chao1 index, B: Simpson index, C: ACE index, D: Shannon index;

[0017] Figure 3 The bar graph shows the relative abundance of fecal microbiota at the phylum level;

[0018] Figure 4 is a bar graph of the relative abundance of fecal microbiota at the genus level;

[0019] Figure 5 The bar graph shows the relative abundance of fecal microbiota at the species level. DETAILED DESCRIPTION

[0020] Various exemplary embodiments of the present invention will now be described in detail. This detailed description should not be considered as limiting the present invention, but rather as a more detailed description of certain aspects, features, and embodiments of the present invention.

[0021] It should be understood that the terms described herein are intended only to describe particular embodiments and are not intended to limit the present invention. In addition, for numerical ranges herein, it should be understood that each intermediate value between the upper and lower limits of the range is also specifically disclosed. Each smaller range between any intermediate value within a stated value or stated range and any other stated value or intermediate value within the stated range is also encompassed by the present invention. The upper and lower limits of these smaller ranges may be independently included or excluded within the scope.

[0022] Unless otherwise indicated, all technical and scientific terms used herein have the same meaning as commonly understood by those skilled in the art. Although only preferred methods and materials are described herein, any methods and materials similar or equivalent to those described herein may also be used in the practice or testing of the present invention. All documents mentioned in this specification are incorporated by reference to disclose and describe the methods and / or materials associated with the documents. In the event of any conflict with any incorporated document, the contents of this specification shall prevail.

[0023] It will be apparent to those skilled in the art that various modifications and variations may be made to the specific embodiments of the present invention without departing from the scope or spirit of the invention. Other embodiments will be apparent to those skilled in the art from the present invention. The present description and examples are intended to be illustrative only.

[0024] The words “include,” “including,” “have,” “contain,” etc. used in this document are open-ended terms, meaning including but not limited to.

[0025] The raw materials used in the present invention can be obtained commercially or prepared using existing technologies.

[0026] The invention provides a traditional Chinese medicine composition comprising the following raw materials in parts by weight: 4-12 parts of acanthopanax senticosus, 3-9 parts of plantain, 3-9 parts of red peony root, 1-3 parts of costus root and 1-3 parts of fructus aurantii.

[0027] In a preferred embodiment of the present invention, the Chinese medicine composition comprises the following raw materials in parts by weight: 12 parts of Acanthopanax senticosus, 9 parts of Plantago, 9 parts of Red Peony Root, 3 parts of Costus Root and 3 parts of Fructus Aurantii Immaturus.

[0028] In a preferred embodiment of the present invention, the Chinese medicine composition comprises the following raw materials in parts by weight: 8 parts of Acanthopanax senticosus, 6 parts of Plantago, 6 parts of Red Peony Root, 2 parts of Costus Root and 2 parts of Citrus Aurantii Immaturus.

[0029] In a preferred embodiment of the present invention, the Chinese medicine composition comprises the following raw materials in parts by weight: 4 parts of Acanthopanax senticosus, 3 parts of Plantago, 3 parts of Red Peony Root, 1 part of Costus Root and 1 part of Citrus Aurantii Immaturus.

[0030] The most preferred ratio of the Chinese medicine composition of the present invention is that the mass ratio of Acanthopanax senticosus, Plantago, Red Peony Root, Aucklandia Root and Fructus Aurantii Immaturus is 4:3:3:1:1.

[0031] According to clinical diagnosis and treatment of traditional Chinese veterinary medicine, the internal organs of weaned piglets are not yet fully developed, their functions are fragile, and they are easily invaded by pathogenic factors such as evil spirits and emotional injury. Therefore, environmental hostility and emotional injury are the main pathogenic factors that cause diarrhea and loss of appetite in piglets. The present invention forms a Chinese medicine composition based on the principles of tranquilizing the mind, regulating qi and activating blood circulation, and unblocking the water channels, which can improve diarrhea caused by weaning stress in piglets. In the Chinese medicine formula, Acanthopanax senticosus, which can tranquilize the mind, is used as the main medicine to relieve the stress reaction of weaned piglets; Plantago, which can unblock the water channels, is used as the auxiliary medicine to promote diuresis and detoxify, and improve the function of piglet internal organs; Red Peony Root is used as the auxiliary medicine to activate blood circulation and remove blood stasis, and promote the excretion of metabolites; Costus Root is used as the adjuvant, and Citrus aurantium is used as the auxiliary medicine to regulate qi and eliminate stagnation, promote gastrointestinal excretion in weaned piglets, and improve gastrointestinal function.

[0032] The present invention also provides a method for preparing the above-mentioned Chinese medicine composition, which is characterized by comprising the following steps:

[0033] The dried Acanthopanax senticosus, Plantago, Paeonia lactiflora, Aucklandia lappa and Fructus Aurantii are mixed and pulverized by a Chinese medicine pulverizer. The pulverized Chinese medicine composition powder is fully mixed by a blender for more than 15 minutes to obtain a Chinese medicine composition.

[0034] In the present invention, the particle size of the traditional Chinese medicine composition is 150-200 meshes.

[0035] The present invention also provides use of the above-mentioned traditional Chinese medicine composition or the traditional Chinese medicine composition prepared by the above-mentioned preparation method in preparing feed for preventing and treating weaning stress in piglets.

[0036] In the present invention, the powder of the Chinese medicinal composition is added to the piglet diet, fully mixed with a blender for 30 minutes, and then dividedly packed into polyethylene woven bags, each bag weighing 5 kg.

[0037] In the present invention, 1 kg of the traditional Chinese medicine composition is mixed into 1000 kg of piglet diet.

[0038] In the present invention, the piglet diet mixed with the traditional Chinese medicine composition is continuously fed to the piglets for 21 days, which can alleviate the stress response of the piglets during weaning.

[0039] The technical solutions provided by the present invention are described in detail below with reference to the embodiments, but they should not be construed as limiting the scope of protection of the present invention.

[0040] Example 1

[0041] Weigh 12 kg of Acanthopanax senticosus, 9 kg of Plantago, 9 kg of Red Peony Root, 3 kg of Costus Root and 3 kg of Citrus Aurantii Immaturus, fully dry them, mix and crush them to a particle size of 150 to 200 meshes, and then fully mix the Chinese medicine composition powder with a blender for no less than 20 minutes to obtain a mixed Chinese medicine composition powder, i.e., a Chinese medicine feed additive.

[0042] Application Example 1

[0043] Weigh 1 kg of the Chinese medicine composition powder of Example 1, add it to 1000 kg of piglet diet, and mix it thoroughly with a blender for 30 minutes to obtain feed mixed with the Chinese medicine composition. Prepare a uniform mixture of the Chinese medicine composition and feed for feeding piglets.

[0044] Test Case

[0045] Sixty-four 28-day-old weaned piglets were divided into a control group (C) and a treatment group (M). The control group was fed a piglet diet, while the treatment group was fed a piglet diet mixed with the traditional Chinese medicine composition prepared in Example 1 for 21 consecutive days. During the treatment period, piglet weight and feed intake were recorded, and feed-to-weight ratio was calculated. The piglets were also observed for diarrhea, fur development, and behavioral activity. On the 22nd day of the experiment, blood samples and feces were collected.

[0046] One portion of the blood was used for routine blood tests, and the other for serum separation. Biochemical kits were used to test piglet serum liver and kidney function, antioxidant enzyme and digestive enzyme activities. ELISA kits were used to measure the levels of inflammatory factors and stress-related genes in piglet serum.

[0047] On day 22, fresh fecal samples were collected from six piglets in each group, aliquoted into clearly labeled cryovials, immediately snap-frozen in liquid nitrogen, and stored in a -80°C ultra-low temperature freezer. The fecal microbiome was then sent to Beijing Biomarker for high-throughput sequencing of 16S rRNA.

[0048] All experimental data were analyzed using GraphPad Prism 8.0.2 software and presented as mean ± standard deviation (mean ± SD). Data were analyzed using one-way analysis of variance (ANOVA), and statistical differences between groups were tested using Tukey's multiple comparison method. Significant differences between groups are indicated by *: P < 0.05, **: P < 0.01, and ***: P < 0.001.

[0049] 1. Changes in growth performance of piglets after weaning

[0050] The results are shown in Table 1. Compared with the control group, the average daily weight gain and daily feed intake of the piglets in the treatment group were significantly increased (P<0.01), and the feed-to-weight ratio was significantly reduced (P<0.05). This shows that the addition of the Chinese herbal composition to the diet has a positive effect on the growth performance of weaned piglets.

[0051] Table 1 Changes in growth performance of piglets after weaning

[0052]

[0053] Note: Compared with the control group, *: P < 0.05, **: P < 0.01, ***: P < 0.001.

[0054] 2. Diarrhea in piglets after weaning

[0055] Diarrhea incidence (%) = (number of piglets with diarrhea × number of days with diarrhea) / (number of piglets × number of trial days) × 100%; diarrhea index = sum of fecal scores / number of piglets × number of trial days. As shown in Table 2, the diarrhea rate in the treated piglets was significantly reduced compared to the control group (P < 0.01), while the diarrhea index showed no significant difference (P > 0.05). This suggests that supplementing the diet with the Chinese herbal composition can reduce diarrhea in weaned piglets.

[0056] Table 2 Diarrhea of ​​piglets after weaning

[0057]

[0058] Note: Compared with the control group, *: P < 0.05, **: P < 0.01, ***: P < 0.001.

[0059] 3. Piglet fur development after weaning

[0060] The redness of the piglet's skin, the brightness of its fur color, and the smoothness of its fur can be used as auxiliary physiological indicators to assess its health status. During the trial, the fur development of the experimental pigs was evaluated according to the fur development assessment standards, and the fur index was calculated. The calculation formula is: fur index = skin redness score + fur color brightness score + fur smoothness score. The scoring method is shown in Table 3

[0061] Table 3 Evaluation of piglet fur development

[0062]

[0063] The results are shown in Table 4. Compared with the control group, the hair smoothness of the piglets in the treatment group was significantly improved (P<0.05), and there was no significant difference in the redness and brightness of the hair (P>0.05). This shows that the addition of the Chinese herbal composition to the diet promotes the development of hair in weaned piglets.

[0064] Table 4. Development of piglet fur after weaning

[0065]

[0066] Note: Compared with the control group, *: P < 0.05, **: P < 0.01, ***: P < 0.001.

[0067] 4. Behavioral changes in piglets after weaning

[0068] Four groups of weaned piglets were observed using video surveillance equipment. Behavioral definitions are shown in Table 5. Eating, lying, exploratory, and aggressive behaviors were recorded instantaneously between 9:00 and 11:00 and 14:00 and 16:00 daily, and the data were averaged. Behavior events were recorded for all piglets. If several piglets engaged in a behavior, the behavior was recorded multiple times; behaviors that did not occur were recorded as not occurring, and the number of behaviors per piglet was averaged. The total number of occurrences of each behavior was recorded and compared with the number of piglets in each group, representing the number of behaviors per piglet during the observation period.

[0069] Table 5 Behavioral performance of piglets

[0070]

[0071] The results are shown in Table 6. Compared with the control group, the piglets in the treatment group showed a significant decrease in aggressive behavior (P < 0.05), while eating, lying, and exploratory behaviors showed no significant changes (P > 0.05). This indicates that the addition of the Chinese herbal composition to the diet has a calming effect, reducing the occurrence of aggressive behavior in piglets after stress.

[0072] Table 6 Behavioral changes of piglets after weaning

[0073]

[0074] Note: Compared with the control group, *: P < 0.05, **: P < 0.01, ***: P < 0.001.

[0075] 5. Routine blood test results of piglets after weaning

[0076] The results of routine blood tests are shown in Table 7. Compared with the control group, the blood routine indicators of the piglets in the treatment group were all within the normal range, with no significant difference (P>0.05). This shows that the intervention of the Chinese herbal composition did not have an adverse effect on the basic hematological status of the piglets.

[0077] Table 7 Changes in blood routine of piglets after weaning

[0078]

[0079] 6. Liver and kidney function of piglets after weaning

[0080] Table 8 shows the results of liver and kidney function tests in piglets. Compared with the control group, the levels of AST, BUN, and CRE in the treated group were significantly reduced (P<0.05), while ALT showed no significant difference (P>0.05). These results indicate that the addition of the Chinese herbal composition to the diet can improve the liver and kidney metabolism of weaned piglets.

[0081] Table 8 Results of liver and kidney function tests in piglets after weaning

[0082]

[0083] Note: Compared with the control group, *: P < 0.05, **: P < 0.01, ***: P < 0.001.

[0084] 7. Digestive enzyme test results of piglets after weaning

[0085] As shown in Table 9, compared with the control group, serum amylase activity in the treated group and piglets was significantly reduced (P < 0.001), while lipase and trypsin activities showed no significant differences (P > 0.05). These results indicate that supplementing the diet with the Chinese herbal composition can reduce serum digestive enzyme activity in piglets after weaning stress and reduce the abnormal leakage of digestive enzymes into the blood.

[0086] Table 9 Digestive enzyme test results of piglets after weaning

[0087]

[0088] Note: Compared with the control group, *: P < 0.05, **: P < 0.01, ***: P < 0.001.

[0089] 8. Antioxidant enzyme test results of piglets after weaning

[0090] As shown in Table 10, compared with the control group, the T-AOC level in the serum of piglets in the treatment group was extremely significantly increased (P < 0.001), and the MDA level was significantly decreased (P < 0.001). These results indicate that the Chinese herbal composition can improve the antioxidant capacity of piglets after weaning stress.

[0091] Table 10 Antioxidant enzyme test results of piglets after weaning

[0092]

[0093] Note: Compared with the control group, *: P < 0.05, **: P < 0.01, ***: P < 0.001.

[0094] 9. Results of inflammatory factor detection in piglets after weaning

[0095] As shown in Table 11, compared with the control group, the levels of IL-6, IL-1β, and TNF-α in the serum of piglets in the treatment group were significantly reduced (P < 0.001). These results indicate that the addition of the Chinese herbal composition to the diet can alleviate the inflammatory damage caused by weaning stress in piglets and reduce the levels of inflammatory factors.

[0096] Table 11 Results of inflammatory factor detection in piglets after weaning

[0097]

[0098] Note: Compared with the control group, *: P < 0.05, **: P < 0.01, ***: P < 0.001.

[0099] 10. Results of stress index test for piglets after weaning

[0100] As shown in Table 12, compared with the control group, the serum CORT and CRP levels of the piglets in the drug group were significantly reduced (P<0.001), and the HSP70 level was significantly reduced (P<0.05). These results indicate that the Chinese herbal composition can alleviate stress damage in piglets.

[0101] Table 12 Results of stress index test for piglets after weaning

[0102]

[0103] Note: Compared with the control group, *: P < 0.05, **: P < 0.01, ***: P < 0.001.

[0104] 11. Alpha diversity analysis results of fecal flora in weaned piglets

[0105] like Figure 2 As shown, alpha diversity reflects the species richness and diversity of individual samples. The Chao1 and Ace indices, as indicators of species richness, primarily reflect the total number of species in a community. The Shannon and Simpson indices measure species diversity. Compared with the control group, the Chao1 and ACE indices of piglets in the drug-treated group were significantly increased (P < 0.05), while the Simpson and Shannon indices showed no significant differences (P > 0.05). These results indicate that supplementing the diet of weaned piglets with a traditional Chinese medicine composition can improve the microbial richness of their fecal microbiota.

[0106] 12. Relative abundance of fecal microbiota at the phylum level

[0107] like Figure 3As shown in the figure, in the piglet fecal microbial community, the distribution of bacterial phyla showed a clear hierarchical characteristic, which was Firmicutes, Bacteroidota, Spirochaetota, Actinobacteria, Proteobacteria, Patescibacteria, Verrucomicrobiota, Desulfobacterota, and Fibrobacterota.

[0108] The three most abundant bacterial phyla in piglet fecal microbiome were Firmicutes, Bacteroidetes, and Spirochaetes. Compared to the control group, piglets in the treated group showed a significant increase in the proportion of Firmicutes, while the proportions of Bacteroidetes and Spirochaetes decreased. This study demonstrates that supplementing the diet with a traditional Chinese medicine composition can effectively increase the abundance of dominant bacterial phyla in piglet fecal microbiota.

[0109] 13. Relative abundance of fecal microbiota at the genus level

[0110] like Figure 4 As shown in the figure, the bacterial genera distributed in piglet feces are as follows: Clostridium sensu stricto 1, Lactobacillus, Treponema, Limosilactobacillus, Christensenellaceae R7 group, Subdoligranulum, and Terrisporobacter.

[0111] Compared with the control group, the relative abundance of Lactobacillus and Limosilactobacillus in the piglets treated with the herbal formula increased, while the relative abundance of Treponema and Terrisporobacter decreased. The results indicate that adding the herbal formula to the diet can effectively promote the proliferation of beneficial bacteria in the piglet fecal microbiome while inhibiting the growth of harmful bacteria, thereby optimizing the microbial community structure.

[0112] 14. Relative abundance of fecal microbiota at the species level

[0113] like Figure 5As shown in the figure, the species distribution in piglet feces is: Clostridium disporicum, Lactobacillus johnsonii, Treponema, Ruminococcaceae bacteria, Limosilactobacillus and Lachnospiraceae bacteria.

[0114] Compared with the control group, the relative abundance of Lactobacillus johnsonii in the treated piglets showed an upward trend, while the relative abundance of Treponema decreased. The results show that adding Chinese herbal medicine to the diet can effectively promote the optimization of the microbial community structure.

[0115] 15. Conclusion

[0116] Adding a powdered Chinese herbal composition to piglet diets can increase weight gain and feed intake after weaning stress, improve feed-to-gain ratio, reduce diarrhea rates, promote fur development after weaning, reduce aggression, and improve growth performance. Furthermore, the Chinese herbal composition can regulate intestinal microbiota, promote digestion, and enhance antioxidant and anti-inflammatory abilities. This suggests that the Chinese herbal composition can alleviate weaning stress in piglets, improve growth performance, and increase the economic benefits of pig farming.

[0117] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principles of the present invention. These improvements and modifications should also be regarded as within the scope of protection of the present invention.

Claims

1. A Chinese medicine composition, characterized in that The invention comprises the following raw materials in parts by weight: 4-12 parts of Acanthopanax senticosus, 3-9 parts of Plantago, 3-9 parts of Red Peony Root, 1-3 parts of Costus Root and 1-3 parts of Citrus Aurantii Immaturus.

2. The Chinese medicine composition according to claim 1, characterized in that The invention comprises the following raw materials in parts by weight: 12 parts of Acanthopanax senticosus, 9 parts of Plantago, 9 parts of Red Peony Root, 3 parts of Aucklandiae Radix and 3 parts of Fructus Aurantii Immaturus.

3. The Chinese medicine composition according to claim 1, characterized in that The invention comprises the following raw materials in parts by weight: 8 parts of Acanthopanax senticosus, 6 parts of Plantago, 6 parts of Red Peony Root, 2 parts of Aucklandia and 2 parts of Fructus Aurantii.

4. The Chinese medicine composition according to claim 1, characterized in that The invention comprises the following raw materials in parts by weight: 4 parts of Acanthopanax senticosus, 3 parts of Plantago, 3 parts of Red Peony Root, 1 part of Aucklandia and 1 part of Fructus Aurantii.

5. The method for preparing the traditional Chinese medicine composition according to any one of claims 1 to 4, characterized in that: The following steps are involved: Acanthopanax senticosus, Plantago, Red Peony Root, Costus Root and Fructus Aurantii Immaturus are mixed and crushed to obtain a traditional Chinese medicine composition.

6. The preparation method according to claim 5, characterized in that The particle size of the traditional Chinese medicine composition is 150-200 meshes.

7. Use of the traditional Chinese medicine composition according to any one of claims 1 to 4 in the preparation of feed for preventing and treating weaning stress in piglets.

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