Functional additive for pregnant sows as well as preparation method and application of functional additive

Abstract

The invention discloses a functional additive for pregnant sows as well as a preparation method and application of the functional additive. The functional additive for the pregnant sows is prepared from the following raw materials in parts by weight: 1 to 2 parts of semen cuscutae, 0.5 to 1.5 parts of herba taxilli, 0.5 to 1.5 parts of radix dipsaci asperoidis, 0.5 to 1.5 parts of radix codonopsis, 0.5 to 1.5 parts of rhizoma atractylodis macrocephalae, 0.5 to 1.5 parts of cortex eucommiae, 0.5 to 1.5 parts of radix paeoniae alba and 0.5 to 1.5 parts of fructus corni. The preparation method comprises the following steps: mixing and crushing the raw materials, boiling with 20 times of pure water, extracting twice, concentrating the filtrate, adding absolute ethyl alcohol until the alcohol content is 60%, standing for 24 hours, filtering, and carrying out rotary evaporation on the filtrate to obtain extract powder; and mixing the extract powder with dextrin according to a ratio of 1: 2.5, preparing a soft material by using 60% ethanol, granulating, drying at 80 DEG C for 30 minutes, and finishing the granules to obtain the granules. The feed can improve the immunity of sows, increase the litter size, reduce the rate of weak piglets and improve the newborn quality of piglets; meanwhile, the formula does not contain any chemical additive, is safe and reliable, and has no toxic or side effect.

Description

Technical Field

[0001] The present invention relates to a functional additive and a preparation method and application thereof, in particular to a functional additive for pregnant sows and a preparation method and application thereof, belonging to the technical field of animal nutrition and feed additives. Background Art

[0002] The gestation period in sows, particularly the late stages, is a critical period for fetal growth and development. During this period, fetal growth increases exponentially, and the demand for nutrition increases dramatically. At the same time, sows are susceptible to external stressors such as environmental and temperature changes, which can lead to a decrease in appetite and, in turn, compromise their reproductive performance and immunity. Currently, common methods for regulating reproductive performance in pregnant sows include feed nutrient manipulation, the use of reproductive hormones, and probiotics. However, these methods pose challenges such as ineffective efficacy, potential for drug residues, and the development of drug resistance, posing potential risks to food safety and the long-term health of sows.

[0003] Traditional Chinese medicine (TCM) offers advantages such as being purely natural, low in toxicity, low in residue, and less susceptible to drug resistance. Incorporating scientifically formulated TCM herbs with benefits such as tocolysis, qi tonification, spleen strengthening, and kidney tonification into pregnant sow feeds promises to be a safe and effective solution for alleviating stress, regulating inflammatory factors, and enhancing immunity and reproductive performance. Therefore, there is an urgent need for a functional additive that can effectively improve reproductive performance and immunity in pregnant sows, while remaining safe and residue-free. Summary of the Invention

[0004] The present invention aims to provide a functional additive for pregnant sows, its preparation method, and its use. The invention can enhance sow immunity, increase litter size, reduce the rate of weak piglets, and improve the birth quality of piglets. Furthermore, the formula of the invention does not contain any chemical additives, making it safe, reliable, and non-toxic.

[0005] To solve the above technical problems, the present invention provides the following technical solutions: a functional additive for pregnant sows, comprising the following raw materials by weight: 1-2 parts of Cuscuta chinensis, 0.5-1.5 parts of Morus alba, 0.5-1.5 parts of Cyathula capitata, 0.5-1.5 parts of Codonopsis pilosula, 0.5-1.5 parts of Atractylodes macrocephala, 0.5-1.5 parts of Eucommia ulmoides, 0.5-1.5 parts of Paeonia lactiflora, and 0.5-1.5 parts of Cornus officinalis.

[0006] The above-mentioned functional additive for pregnant sows includes the following raw materials by weight: 1-1.5 parts of Cuscuta chinensis, 0.8-1.2 parts of Morus alba, 0.8-1.2 parts of Cyathula capitata, 0.8-1.2 parts of Codonopsis pilosula, 0.8-1.2 parts of Atractylodes macrocephala, 0.8-1.2 parts of Eucommia ulmoides, 0.8-1.2 parts of White Peony Root, and 0.8-1.2 parts of Cornus officinalis.

[0007] The aforementioned functional additive for pregnant sows comprises the following raw materials by weight: 1.318 parts of Cuscuta chinensis, 1 part of Morus alba, 1 part of Rhizoma Chuanxiong, 1 part of Codonopsis pilosula, 1 part of Atractylodes macrocephala, 1 part of Eucommia ulmoides, 1 part of Paeonia lactiflora, and 1 part of Cornus officinalis.

[0008] The preparation method of the aforementioned functional additive for pregnant sows, wherein the functional additive for pregnant sows is a traditional Chinese medicine compound extract powder, is prepared by mixing and crushing the raw materials in proportion, then boiling and extracting twice with 20 times the volume of pure water, each time for 1 hour, and combining the filtrate; after concentrating the filtrate, adding anhydrous ethanol to make the alcohol content reach 60%, standing for 24 hours and then filtering; rotary evaporating the filtrate to remove the solvent, and concentrating to obtain the traditional Chinese medicine compound extract powder.

[0009] The aforementioned preparation method, the functional additive for pregnant sows is a granule, and its preparation method is to mix the Chinese medicine extract powder and dextrin in a ratio of 1:2.5, use 60% ethanol solution as a wetting agent to make a soft material, and then extrude granules, dry at 80°C for 30 minutes and then sieve to obtain granules.

[0010] The quality standards of the granules in the above-mentioned preparation method are: no foreign matter and coke dust after melting, the qualified rate of granules is not less than 85%, and the moisture content does not exceed 8%.

[0011] The application of the aforementioned functional additive for pregnant sows in the preparation of a feed additive for improving the reproductive performance of pregnant sows.

[0012] In the above application, the additive is added to the basic feed of pregnant sows in an amount of 2% by weight of the feed.

[0013] In the aforementioned application, the improved reproductive performance includes increasing litter size and litter weight of newborn piglets.

[0014] In the aforementioned application, the additive is used to increase the IFN-γ content in the milk of pregnant sows and reduce the TNF-α, IL-6, and IL-1β contents.

[0015] Compared with the prior art, the present invention has the following significant beneficial effects: 1. Adding the functional additive of the present invention to the basic diet of pregnant sows can significantly increase the number of piglets born and the litter weight of newborn piglets (P < 0.01), and also has a positive trend in improving the survival rate of piglets and the body condition score of sows.

[0016] 2. The present invention can significantly increase the content of the anti-inflammatory factor IFN-γ in the milk of pregnant sows, while significantly reducing the content of the pro-inflammatory factors TNF-α, IL-6, and IL-1β, indicating that it can significantly enhance the immune ability and health level of pregnant sows by regulating the body's inflammatory factor network.

[0017] 3. The present invention uses only natural, low-toxic, and low-residue ingredients that are both medicinal and edible, or traditional Chinese medicine. This avoids the problem of chemical and hormone residues and ensures the safety of animal-derived foods. Furthermore, after being made into granules, they have good fluidity, are easy to mix evenly with feed, and have good palatability, making them convenient for industrial production and large-scale farm applications. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 This is a schematic diagram comparing the IFN-γ content in the plasma of sows in the experimental group and the control group; Figure 2 This is a schematic diagram comparing the levels of TNF-α in the plasma of sows in the experimental group and the control group; Figure 3 This is a schematic diagram comparing the levels of TNF-6 in the plasma of sows in the experimental group and the control group; Figure 4 This is a schematic diagram comparing the TNF-1β content in the plasma of sows in the experimental group and the control group. DETAILED DESCRIPTION

[0019] The present invention will be further described below with reference to the embodiments.

[0020] Example 1: Preparation of a functional additive for pregnant sows. This example is the preparation of a Chinese medicine compound extract powder, including weighing the raw materials: according to a weight ratio of 2:1:1:1:1:1:1:1, weigh 20kg of Cuscuta chinensis, 10kg of Morus alba, 10kg of Cyathula capitata, 10kg of Codonopsis pilosula, 10kg of Atractylodes macrocephala, 10kg of Eucommia bark, 10kg of Paeonia lactiflora, and 10kg of Cornus officinalis; Extract preparation: The above raw materials were mixed and crushed, and 20 times the volume (based on the total weight of the raw materials, the total weight was 90 kg, so the amount of water added was 1800 L) of pure water was added. The mixture was boiled for 1 hour and filtered. The filter residue was added with an equal amount of pure water and boiled again for 1 hour. The two filtrates were combined. The filtrate was concentrated, and anhydrous ethanol was added to bring the alcohol content to 60%. The mixture was allowed to stand at room temperature for 24 hours and then filtered. The solvent was removed from the filtrate by rotary evaporation (55°C, -0.085 MPa) to obtain a traditional Chinese medicine compound extract powder.

[0021] Example 2: Preparation of a functional additive for pregnant sows. This example is the preparation of a Chinese medicine compound extract powder, including weighing the raw materials: according to a weight ratio of 1.318:1:1:1:1:1:1:1, weigh 13.18 kg of Cuscuta chinensis, 10 kg of Morus alba, 10 kg of Cyathula capitata, 10 kg of Codonopsis pilosula, 10 kg of Atractylodes macrocephala, 10 kg of Eucommia bark, 10 kg of Paeonia lactiflora, and 10 kg of Cornus officinalis. Extract preparation: The above raw materials were mixed and ground, and 20 volumes of pure water (based on the total weight of the raw materials, the total weight was 83.18 g, so the amount of water added was 1663.6 mL) was added. The mixture was boiled for 1 hour and filtered. The filter residue was added with an equal amount of pure water and boiled again for 1 hour. The two filtrates were combined. The filtrate was concentrated, and anhydrous ethanol was added to bring the alcohol content to 60%. The mixture was allowed to stand at room temperature for 24 hours and then filtered. The solvent was removed from the filtrate by rotary evaporation (55°C, -0.085 MPa) to obtain approximately 8.5 kg of the traditional Chinese medicine compound extract powder.

[0022] Example 3: Preparation of functional additive granules for pregnant sows: 8.5 kg of the above-mentioned traditional Chinese medicine compound extract powder prepared in Example 2 was weighed, 21.25 kg of dextrin was added (extract powder: dextrin = 1:2.5), and after mixing evenly, 60% ethanol solution was added to prepare a soft material ("knead into a ball by hand, and it will fall apart when pressed lightly"); the soft material was extruded through a No. 1 sieve to prepare granules, and the wet granules were dried at 80°C for 30 minutes. After drying, they were sieved through a No. 1 sieve to remove coarse particles and sieved through a No. 5 sieve to remove fine powder, to obtain approximately 27.8 kg of functional additive granules for pregnant sows; Quality inspection: The above granule samples were taken, and the test results were: there was no foreign matter and coke dust after melting, the granule qualification rate was 92%, the moisture content was 6.5%, and the comprehensive score was 83.2, which met the quality standards.

[0023] Example 4: Effect of the functional additive for pregnant sows on the reproductive performance of pregnant sows.

[0024] 40 healthy pregnant sows with similar parity and weight were selected and randomly divided into a control group (20 sows) and an experimental group (20 sows): Control group: fed with basic feed for pregnant sows; The experimental group was fed with a basic feed for pregnant sows supplemented with 2% by weight of the functional additive granules for pregnant sows of the present invention (prepared in Example 3); The experimental period was from 85 days of gestation of sows (late gestation) to weaning of piglets (21 days after delivery).

[0025] Table 1 shows the effects of the functional additive for pregnant sows of the present invention on the reproductive performance of sows: project control group experimental group value litter size 11.78±0.28 13.44±0.41 0.004 Weakling rate 0.519±0.14 0.301±0.13 0.251 Newborn piglet litter weight 17.830±0.13 21.072±0.10 0.000 Piglet survival rate 96.250±1.44 98.304±0.896 0.238 Sow body condition score 3.250±0.14 3.467±0.192 0.370 Table 1 As can be seen from Table 1, the average number of piglets born by sows in the experimental group was 1.2 higher per litter than that in the control group (P < 0.01), and the average litter weight of newborn piglets was 2.8 kg higher than that in the control group (P < 0.01); the piglet survival rate was 96.5% in the experimental group and 94.5% in the control group (an increase of 2%); the weak piglet rate was 1.8% in the experimental group and 2.0% in the control group (a decrease of 0.2%); the sow body condition score was 3.2 points in the experimental group and 3.0 points in the control group (an increase of 0.2 points).

[0026] Furthermore, the cytokine content in colostrum of pregnant sows was detected, and the results were as follows: Figure 1-4 As shown, Figure 1 This is a schematic diagram comparing the IFN-γ content in the plasma of sows in the experimental group and the control group; Figure 2 This is a schematic diagram comparing the levels of TNF-α in the plasma of sows in the experimental group and the control group; Figure 3 This is a schematic diagram comparing the levels of TNF-6 in the plasma of sows in the experimental group and the control group; Figure 4 The figure is a comparison of the TNF-1β content in the plasma of sows in the experimental group and the control group. In the figure, the "**" and "***" indicate significant differences compared with the control group (P < 0.01). Figures 1 to 4 It can be seen that compared with the control group, adding 2% granules to the basic feed of pregnant sows can significantly increase the content of IFN-γ in sow milk (P < 0.01) and significantly reduce the content of TNF-α, IL-6, and IL-1β (P < 0.01).

[0027] The above examples show that the functional additive for pregnant sows of the present invention can effectively improve the reproductive performance and immune ability of pregnant sows, and has significant application value.

Claims

1. A functional additive for pregnant sows, characterized in that: The invention comprises the following raw materials by weight: 1-2 parts of Cuscuta seeds, 0.5-1.5 parts of Morus alba, 0.5-1.5 parts of Cyathula capitata, 0.5-1.5 parts of Codonopsis pilosula, 0.5-1.5 parts of Atractylodes macrocephala, 0.5-1.5 parts of Eucommia ulmoides, 0.5-1.5 parts of Paeonia lactiflora, and 0.5-1.5 parts of Cornus officinalis.

2. The functional additive for pregnant sows according to claim 1, characterized in that: The invention comprises the following raw materials by weight: 1-1.5 parts of Cuscuta chinensis, 0.8-1.2 parts of Morus alba, 0.8-1.2 parts of Rhizoma Chuanxiong, 0.8-1.2 parts of Codonopsis pilosula, 0.8-1.2 parts of Atractylodes macrocephala, 0.8-1.2 parts of Eucommia ulmoides, 0.8-1.2 parts of Paeonia lactiflora, and 0.8-1.2 parts of Fructus Corni.

3. The functional additive for pregnant sows according to claim 2, characterized in that: The following raw materials are included by weight: 1.318 parts of Cuscuta seeds, 1 part of Morus alba, 1 part of Rhizoma Chuanxiong, 1 part of Codonopsis pilosula, 1 part of Atractylodes macrocephala, 1 part of Eucommia ulmoides, 1 part of White Peony Root, and 1 part of Fructus Corni.

4. The method for preparing the functional additive for pregnant sows according to any one of claims 1 to 3, characterized in that: The functional additive for pregnant sows is a traditional Chinese medicine compound extract powder, and its preparation method is as follows: various raw materials are mixed and crushed in proportion, and then boiled and extracted twice with 20 times the volume of pure water, each time for 1 hour, and the filtrates are combined; after concentrating the filtrate, anhydrous ethanol is added to make the alcohol content reach 60%, and the filtrate is allowed to stand for 24 hours and then filtered; the filtrate is rotary evaporated to remove the solvent, and concentrated to obtain the traditional Chinese medicine compound extract powder.

5. The preparation method according to claim 4, characterized in that: The functional additive for pregnant sows is a granule, and its preparation method is: Chinese medicine extract powder and dextrin are mixed in a ratio of 1:2.5, 60% ethanol solution is used as a wetting agent to prepare a soft material, and then after extrusion granulation, it is dried at 80°C for 30 minutes and then sieved to obtain the granule.

6. The preparation method according to claim 5, characterized in that: The quality standards of the granules are: no foreign matter and coke dust after melting, the qualified rate of granules is not less than 85%, and the moisture content does not exceed 8%.

7. Use of the functional additive for pregnant sows according to any one of claims 1 to 3 in the preparation of a feed additive for improving the reproductive performance of pregnant sows.

8. The use according to claim 7, characterized in that The additive is added to the basic feed for pregnant sows in an amount of 2% by weight of the feed.

9. The use according to claim 7, characterized in that The improved reproductive performance includes increasing litter size and litter weight of newborn piglets.

10. The use according to claim 7, characterized in that The additive is used for increasing the IFN-γ content in the milk of pregnant sows and reducing the TNF-α, IL-6 and IL-1β contents.

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