Anti-hair-loss hair-growing product containing plant extract components and preparation method of anti-hair-loss hair-growing product

Abstract

The invention provides an anti-hair-loss and hair-growing product containing plant extract components and a preparation method thereof, and relates to the field of wash supplies, the anti-hair-loss and hair-growing product is prepared from the following raw materials by weight: 50-80 parts of water, 5-10 parts of propylene glycol, 1-5 parts of 1, 3-propylene glycol, 1-5 parts of 1, 3-propylene glycol, and 1-5 parts of 1, 3-propylene glycol. The composition is prepared from the following components in parts by weight: 0.1 to 1 part of 1, 2-pentanediol, 0.1 to 1 part of pyrrolidinyl diaminopyrimidine oxide, 0.1 to 0.5 part of diaminopyrimidine oxide, 0.01 to 0.02 part of caffeine, 0.01 to 0.1 part of adenosine, 0.05 to 0.2 part of vitamin B6, 0.01 to 0.5 part of biotin tripeptide-1, 0.1 to 1 part of dipotassium glycyrrhizinate, 0.02 to 0.05 part of ethylenediamine tetraacetic acid, 0.1 to 1 part of D panthenol, 0.2 to 1 part of p-hydroxyacetophenone, 0.01 to 1 part of 1, 2-pentanediol, 0.1 to 1 part of 1, 2-pentanediol, 0.1 to 1 part of 2, 2-pentanediol, 0.1 to 1 part of 2, 2-pentanediol, 0.1 to 1 part of 2, 2- The composition comprises the following components in parts by weight: 1-2 parts of 1, 2-hexanediol, 0.1-0.5 part of citric acid, 1-2 parts of 1, 3-butanediol, 0.01-1 part of NMN and 3-5 parts of a plant extract. According to the present invention, the extraction method of the plant extract in the raw materials is specifically adjusted so as to significantly reduce the content of the pigment and the odor substance in the extract, such that the obtained hair growing liquid has characteristics of good hair growing effect, light color and light drug taste, can be easily accepted by consumers, and is suitable for large-scale promotion and application.

Description

Technical Field

[0001] The present invention relates to the technical field of toiletries, and in particular to a hair loss prevention and hair growth product containing plant extract ingredients and a preparation method thereof. Background Art

[0002] As the age of the population experiencing hair loss increases, anti-hair loss and hair growth products based on plant extracts such as Polygonum multiflorum, Platycladus orientalis, Ginseng, Salvia miltiorrhiza, and Rosemary have become popular. However, consumer research shows that negative reviews for these products, including "too dark color, pungent odor, and scalp stinging after use," account for over 60% of all negative reviews, becoming a major barrier to their widespread adoption.

[0003] Research has found that the color problems of plant extracts are primarily caused by dark anthraquinone pigments and tannin-protein complexes. For example, anthraquinone glycosides such as emodin, chrysophanol, and rhein in Polygonum multiflorum are easily oxidized into dark quinone-type products. Furthermore, high-polymer proanthocyanidins are found in Platycladus orientalis leaves and Chinese gallnut. The medicinal flavor of plant extracts is primarily caused by volatile oils and free anthraquinone aglycones. For example, α-thujone, β-thujone, and sesquiterpenes in Platycladus orientalis leaves have a strong camphor-like odor, while free anthraquinone aglycones in Polygonum multiflorum have a strong bitter almond flavor. Therefore, effectively removing anthraquinones, tannins, and volatile oils from plant extracts is a key approach to improving the color and medicinal flavor of plant extracts.

[0004] Currently, activated carbon decolorization, essence masking, macroporous resin adsorption, and microbial fermentation are commonly used in existing technologies to improve the color and medicinal taste of plant extracts. However, activated carbon decolorization also adsorbs active ingredients, resulting in a 30-50% decrease in the yield of effective ingredients; essence compounding increases raw material costs and can easily cause allergies; macroporous resin adsorption greatly increases production equipment costs and has the problem of easy pollution; microbial fermentation has a long cycle, a complex fermentation process, and is difficult to control. Therefore, developing a method that can specifically improve the color and odor problems of plant extracts without significantly reducing the yield of effective ingredients will have a positive effect on expanding the production and sales scale of anti-hair loss and hair growth products. Summary of the Invention

[0005] The present invention provides an anti-hair loss and growth product containing plant extract ingredients and a preparation method thereof. By specifically adjusting the extraction method of the plant extract in the raw materials, the content of pigments and odorous substances in the extract is significantly reduced without significantly affecting the yield of the effective ingredients. As a result, the obtained hair growth liquid has the characteristics of good hair growth effect, light color, and light medicinal taste, is more easily accepted by consumers, and is more suitable for large-scale promotion and application.

[0006] To achieve the above-mentioned purpose, the present invention provides an anti-hair loss and hair growth product, which is prepared by the following raw materials in parts by weight: 50-80 parts of water, 5-10 parts of propylene glycol, 1-5 parts of 1,2-pentanediol, 0.1-1 parts of pyrrolidino diaminopyrimidine oxide, 0.1-0.5 parts of diaminopyrimidine oxide, 0.01-0.02 parts of caffeine, 0.01-0.1 parts of adenosine, 0.05-0.2 parts of vitamins B6, 0.01-0.5 parts of biotin tripeptide-1, 0.1-1 parts of dipotassium glycyrrhizate, 0.02-0.05 parts of ethylenediaminetetraacetic acid, 0.1-1 parts of D-panthenol, 0.2-1 parts of p-hydroxyacetophenone, 0.01-1 parts of 1,2-hexanediol, 0.1-0.5 parts of citric acid, 1-2 parts of 1,3-butylene glycol, 0.01-1 parts of NMN (β-nicotinamide mononucleotide), 3-5 parts of plant extracts;

[0007] The plant extract is a mixed extract of Ajuga strychnifolia, Polygonum multiflorum (prepared), Platycladus orientalis leaf, mulberry leaf, licorice root, Ligustrum lucidum fruit, ginseng, Notopterygium wilfordii and Angelica sinensis;

[0008] The extraction method of the plant extract comprises the following steps:

[0009] (1) Grinding and mixing Ajuga sibiricum, Radix Polygoni Multiflori, and Platycladus orientalis leaves in proportion, performing heating and refluxing extraction with 5-10 times the mass of 60% ethanol aqueous solution, and filtering the filtrate to obtain a first crude extract;

[0010] After crushing and mixing mulberry leaves, licorice, glossy privet fruit, ginseng, notopterygium root and angelica according to proportion, heating and refluxing extraction was carried out with 5-10 times the mass of 60% ethanol aqueous solution, and the filtrate was filtered to obtain a second crude extract;

[0011] (2) After concentrating the first crude extract to 0.4-0.6 times the weight of the raw material, add citric acid to adjust the pH to 4-5, and let it stand at 2-4°C for 1-2 hours. Filter the filtrate to obtain the first refined extract;

[0012] After concentrating the second crude extract to 0.4-0.6 times the weight of the raw material, add citric acid to adjust the pH to 4-5, and let it stand at 2-4°C for 1-2 hours, filter the filtrate to obtain the second refined extract;

[0013] (3) Adding 0.05-0.1 mol / L sodium hydrogen phosphate solution to the first refined extract to adjust the pH value to 6.5-7.0, then adding petroleum ether with a boiling range of 60-70°C for stirring and mixing extraction. After standing and stratification, remove the lower aqueous solution and concentrate it to 5-7% of the weight of the raw material to obtain the first extract;

[0014] Concentrating the second refined extract to 5-7% of the weight of the raw material to obtain a second extract;

[0015] (4) The first extract and the second extract are mixed uniformly in a volume ratio of 1:1 to obtain a plant extract.

[0016] The present invention discloses an anti-hair loss and growth product. During the extraction process of the added plant extract, not only the dark matter can be precipitated and separated in large quantities by targetedly adjusting the extract concentration, temperature and pH value based on the principle that the solubility difference between dark matter and effective ingredients in the plant extract is large under specific temperature and pH conditions, but the content of the dark matter in the plant extract is significantly reduced. At the same time, according to the difference in solubility between odorous substances and effective ingredients in the extract in petroleum ether in a specific boiling range, the extractant is targetedly selected, and when sodium dihydrogen phosphate at a specific concentration is used as a stabilizer, the loss of effective ingredients is avoided, and efficient extraction and separation of odorous substances is achieved, so that the content of odorous substances in the plant extract is significantly reduced. Therefore, the anti-hair loss and growth product has the advantages of moist texture, easy penetration and absorption, good effect of promoting hair growth and preventing hair follicle damage, and also has the characteristics of light color and light medicinal taste, is more easily accepted by consumers, and is conducive to the large-scale promotion and application of the anti-hair loss and growth product.

[0017] Among them, preferably, the plant extract is obtained by extracting from Ajuga strychnifolia, Polygonum multiflorum processed, Platycladus orientalis leaves, mulberry leaves, licorice, Ligustrum lucidum fruit, ginseng, Notopterygium wilfordii and Angelica sinensis in a mass ratio of 5-10:1:1:1:1:1:1:1:1:1; with the preferred raw material ratio, the effective ingredients in the plant extract can produce a synergistic effect, thereby making the hair growth liquid have a better hair growth effect.

[0018] Among them, preferably, in the anti-hair loss and hair growth product, the weight ratio of pyrrolidino diaminopyrimidine oxide to diaminopyrimidine oxide is 2-3:1; the combined use of diaminopyrimidine oxide and pyrrolidino diaminopyrimidine oxide in a specific ratio can more effectively promote hair growth and prevent hair follicle damage.

[0019] Among them, in step (1), preferably, the temperature of the heating reflux extraction is not higher than 70°C, and the time is not less than 4 hours; if the heating temperature is too high or the heating time is too long, the effective ingredients (such as diphenylethylene glycosides, etc.) will be decomposed and denatured in large quantities, thereby greatly reducing the efficacy of the plant extract; more preferably, the temperature of the heating reflux extraction is 50-70°C, and the time is 4-6 hours; the extraction energy consumption is low and the extraction effect is good.

[0020] Among them, preferably, when performing heating reflux extraction, the ethanol aqueous solution is refluxed for extraction 2-3 times (such as: first add 3 times the weight of 60% ethanol aqueous solution, heat and reflux for 4 hours, filter to obtain the first filtrate for standby use; add 2 times the weight of 60% ethanol aqueous solution to the filter residue, heat and reflux for 4 hours, filter to obtain the second filtrate for standby use; add 2 times the weight of 60% ethanol aqueous solution to the filter residue, heat and reflux for 4 hours, and mix the filtered filtrate with the first filtrate and the second filtrate to obtain the first crude extract); by extracting in batches, the extraction yield can be improved.

[0021] Wherein, in step (2), preferably, the first crude extract and the second crude extract are concentrated by a reduced pressure concentration method; reduced pressure concentration is fast and has a low temperature, and can better achieve rapid concentration at a lower temperature and shorten the concentration time.

[0022] Preferably, the temperature for vacuum concentration of the first crude extract is not higher than 60° C.; the temperature for vacuum concentration of the second crude extract is not higher than 80° C. The preferred concentration temperature can shorten the concentration time without affecting the efficacy of the drug.

[0023] Preferably, suction filtration is used for filtration; filtration can separate the anthraquinone substances precipitated during the low-temperature acidification process from the tanning agent, thereby significantly reducing the dark matter in the extract, with a fast suction filtration speed and a good separation effect.

[0024] In step (3), preferably, the amount of petroleum ether added is 0.1-0.2 times the volume of the first extract; the preferred amount of addition can better extract the odorous substances in the extract while reducing the amount of petroleum ether used.

[0025] Preferably, the standing time after extraction is 3-5 hours; the preferred standing time can better achieve stratification, while standing time that is too long will cause oxidation of some active ingredients.

[0026] Preferably, the concentration is carried out by vacuum concentration; more preferably, the temperature for vacuum concentration of the first extract is not higher than 60°C; the temperature for vacuum concentration of the second extract is not higher than 80°C; the preferred concentration temperature can achieve a concentration effect more quickly without affecting the efficacy of the drug.

[0027] In order to achieve the above-mentioned object of the invention, the present invention further provides a method for preparing an anti-hair loss and hair growth product, comprising the following steps:

[0028] S1: Mix water, propylene glycol, caffeine, 1,2-pentanediol, pyrrolidinopyrimidine oxide, diaminopyrimidine oxide, adenosine, vitamin B6, biotin tripeptide-1, dipotassium glycyrrhizate, ethylenediaminetetraacetic acid, D-panthenol, p-hydroxyacetophenone, 1,2-hexanediol, citric acid, 1,3-butylene glycol, and NMN according to the formula amount, and homogenize and disperse them to obtain a mixed solution;

[0029] S2: Add the formulated amount of plant extract to the mixed liquid and mix well to obtain the anti-hair loss and hair growth product.

[0030] Among them, preferably, in step S1, the homogenizing and dispersing equipment is any one of a high-pressure homogenizer, an ultrasonic homogenizer, a colloid mill, a vortex mixer, and a microfluidizer.

[0031] Preferably, in step S1, the homogenization dispersion time is 10-15 minutes.

[0032] Compared with the prior art, the present invention has the following beneficial effects:

[0033] (1) The present invention provides an anti-hair loss and hair growth product. During the extraction process of the added plant extract, the concentration, temperature and pH value of the extract are specifically adjusted so that a large amount of dark matter can be precipitated and separated, thereby significantly reducing the content of dark matter in the plant extract, thereby making the anti-hair loss and hair growth product lighter in color, which is conducive to the large-scale promotion and application of the anti-hair loss and hair growth product.

[0034] (2) The present invention provides an anti-hair loss and growth product. During the extraction process, the plant extract is added. By selecting the extraction agent in a targeted manner and using sodium dihydrogen phosphate at a specific concentration as a stabilizer, the loss of a large amount of effective ingredients is avoided, and the efficient extraction and separation of odor substances is achieved, thereby significantly reducing the content of odor substances in the plant extract. As a result, the medicinal taste of the anti-hair loss and growth product is light, which is conducive to the large-scale promotion and application of the anti-hair loss and growth product.

[0035] (3) The anti-hair loss and hair growth product of the present invention contains a variety of hair growth and hair care ingredients. In addition to having the advantages of moist texture, easy penetration and absorption, and good effects in promoting hair growth and preventing hair follicle damage, it also has the characteristics of light color and light medicinal taste, which makes it easier for consumers to accept and is conducive to the large-scale promotion and application of the anti-hair loss and hair growth product. DETAILED DESCRIPTION

[0036] To make the objectives, technical solutions, and advantages of the embodiments of the present invention more clear, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making any creative efforts shall fall within the scope of protection of the present invention.

[0037] In this document, the term "and / or" simply describes a relationship between related objects, indicating that three possible relationships exist. For example, "A and / or B" can represent: A exists alone, A and B exist simultaneously, or B exists alone. Furthermore, the character " / " in this document generally indicates that the related objects are in an "or" relationship.

[0038] Example 1,

[0039] A hair loss prevention and hair growth product, comprising the following raw materials in parts by weight: 65 parts of water, 8 parts of propylene glycol, 3 parts of 1,2-pentanediol, 0.5 parts of pyrrolidinopyrimidine oxide, 0.25 parts of diaminopyrimidine oxide, 0.015 parts of caffeine, 0.05 parts of adenosine, 0.1 parts of vitamin B6, 0.25 parts of biotin tripeptide-1, 0.5 parts of dipotassium glycyrrhizate, 0.035 parts of ethylenediaminetetraacetic acid, 0.5 parts of D-panthenol, 0.6 parts of p-hydroxyacetophenone, 0.5 parts of 1,2-hexanediol, 0.35 parts of citric acid, 1.5 parts of 1,3-butylene glycol, 0.5 parts of NMN, and 4 parts of plant extracts;

[0040] The plant extract is a mixed extract of Ajuga sibiricum, Polygonum multiflorum (prepared), Platycladus orientalis leaves, mulberry leaves, licorice, Ligustrum lucidum fruit, ginseng, Notopterygium wilfordii and Angelica sinensis in a mass ratio of 8:1:1:1:1:1:1:1:1;

[0041] The extraction method of the plant extract comprises the following steps:

[0042] (1) After grinding and mixing Ajuga sibiricum, Radix Polygoni Multiflori, and Platycladus orientalis leaves in proportion, first add 4 times the weight of 60% ethanol aqueous solution, heat (60°C) and reflux for 4 hours, filter to obtain the first filtrate for standby use; add 2 times the weight of 60% ethanol aqueous solution to the filter residue, heat (60°C) and reflux for 4 hours, filter to obtain the second filtrate for standby use; add 2 times the weight of 60% ethanol aqueous solution to the filter residue, heat (60°C) and reflux for 4 hours, and mix the filtered filtrate with the first filtrate and the second filtrate to obtain the first crude extract;

[0043] After mulberry leaves, liquorice, glossy privet fruit, ginseng, notopterygium root and angelica root are crushed and mixed in proportion, 4 times the weight of 60% ethanol aqueous solution are added, heated (60°C) and refluxed for 4 hours, and filtered to obtain a first filtrate for use; 2 times the weight of 60% ethanol aqueous solution are added to the filter residue, heated (60°C) and refluxed for 4 hours, and filtered to obtain a second filtrate for use; 2 times the weight of 60% ethanol aqueous solution are added to the filter residue, heated (60°C) and refluxed for 4 hours, and the filtered filtrate is mixed with the first filtrate and the second filtrate to obtain a second crude extract;

[0044] (2) The first crude extract was concentrated under reduced pressure (vacuum degree 0.05 MPa, temperature 50°C) to 0.5 times the weight of the raw material, and citric acid was added to adjust the pH value to 4.5. The mixture was allowed to stand at 3°C ​​for 1.5 hours, and the filtrate was filtered (suction filtered) to obtain the first refined extract;

[0045] The second crude extract was concentrated under reduced pressure (vacuum degree 0.05 MPa, 50°C) to 0.5 times the weight of the raw material, and then citric acid was added to adjust the pH value to 4.5. The extract was allowed to stand at 3°C ​​for 1.5 hours, and the filtrate was filtered (suction filtered) to obtain the second refined extract.

[0046] (3) After adding 0.075 mol / L sodium hydrogen phosphate solution to the first extract to adjust the pH value to 6.5, petroleum ether with a boiling range of 60-70°C (the amount added is 0.15 times the volume of the first extract) is added for stirring and extraction. After standing for 4 hours to separate the layers, the lower aqueous solution is removed and then concentrated under reduced pressure (vacuum degree 0.05 MPa, 50°C) to 6% of the weight of the raw material to obtain the first extract;

[0047] The second refined extract was concentrated under reduced pressure (vacuum degree 0.05 MPa, 60°C) to 6% of the weight of the raw material to obtain a second extract;

[0048] (4) The first extract and the second extract are mixed uniformly in a volume ratio of 1:1 to obtain a plant extract.

[0049] The preparation method of the anti-hair loss and hair growth product is as follows:

[0050] S1: Water, propylene glycol, caffeine, 1,2-pentanediol, pyrrolidinopyrimidine oxide, diaminopyrimidine oxide, adenosine, vitamin B6, biotin tripeptide-1, dipotassium glycyrrhizate, ethylenediaminetetraacetic acid, D-panthenol, p-hydroxyacetophenone, 1,2-hexanediol, citric acid, 1,3-butylene glycol, and NMN were mixed according to the formula amount and homogenized (homogenizer, homogenization for 12 minutes) to obtain a mixed solution;

[0051] S2: Add the formulated amount of plant extract to the mixed liquid and mix well to obtain the anti-hair loss and hair growth product.

[0052] Example 2,

[0053] A hair loss prevention and growth product, comprising the following raw materials in parts by weight: 50 parts of water, 10 parts of propylene glycol, 5 parts of 1,2-pentanediol, 1 part of pyrrolidinopyrimidine oxide, 0.1 part of diaminopyrimidine oxide, 0.02 parts of caffeine, 0.01 parts of adenosine, 0.05 parts of vitamin B6, 0.5 parts of biotin tripeptide-1, 0.1 parts of dipotassium glycyrrhizate, 0.05 parts of ethylenediaminetetraacetic acid, 0.1 parts of D-panthenol, 0.2 parts of p-hydroxyacetophenone, 0.01 parts of 1,2-hexanediol, 0.5 parts of citric acid, 2 parts of 1,3-butylene glycol, 0.01 parts of NMN, and 3 parts of plant extracts;

[0054] The plant extract is a mixed extract of Ajuga strychnifolia, Polygonum multiflorum (prepared), Platycladus orientalis leaves, mulberry leaves, liquorice, Ligustrum lucidum fruit, ginseng, Notopterygium wilfordii and Angelica sinensis in a mass ratio of 5:1:1:1:1:1:1:1:1;

[0055] The extraction method of the plant extract comprises the following steps:

[0056] (1) After grinding and mixing Ajuga sibiricum, Polygonum multiflorum processed, and Platycladus orientalis leaves in proportion, the mixture was heated (70°C) and refluxed for 6 h using a 5-fold amount of 60% ethanol aqueous solution, and the filtrate was filtered to obtain the first crude extract;

[0057] After crushing and mixing mulberry leaves, liquorice, glossy privet fruit, ginseng, notopterygium root and angelica according to the proportion, the mixture was heated (70°C) and refluxed for 6 hours using 5 times the mass of 60% ethanol aqueous solution, and the filtrate was filtered to obtain the second crude extract;

[0058] (2) The first crude extract was concentrated under reduced pressure (vacuum degree 0.05 MPa, temperature 60°C) to 0.4 times the weight of the raw material, and citric acid was added to adjust the pH value to 5. The mixture was allowed to stand at 2°C for 2 h, and the filtrate was filtered (suction filtered) to obtain the first refined extract;

[0059] The second crude extract was concentrated under reduced pressure (vacuum degree 0.05 MPa, temperature 70°C) to 0.4 times the weight of the raw material, and then citric acid was added to adjust the pH value to 5. The extract was allowed to stand at 2°C for 2 hours, and the filtrate was filtered (suction filtration) to obtain the second refined extract.

[0060] (3) After adding 0.1 mol / L sodium hydrogen phosphate solution to the first extract to adjust the pH value to 6.5, petroleum ether with a boiling range of 60-70°C (the amount added is 0.2 times the volume of the first extract) is added for stirring and mixing extraction. After standing for 5 hours to separate the layers, the lower aqueous solution is removed and then concentrated under reduced pressure (vacuum degree 0.05 MPa, 50°C) to 5% of the weight of the raw material to obtain the first extract;

[0061] The second refined extract was concentrated under reduced pressure (vacuum degree 0.05 MPa, 60°C) to 5% of the weight of the raw material to obtain a second extract;

[0062] (4) The first extract and the second extract are mixed uniformly in a volume ratio of 1:1 to obtain a plant extract.

[0063] The preparation method of the anti-hair loss and hair growth product is as follows:

[0064] S1: Water, propylene glycol, caffeine, 1,2-pentanediol, pyrrolidinopyrimidine oxide, diaminopyrimidine oxide, adenosine, vitamin B6, biotin tripeptide-1, dipotassium glycyrrhizate, ethylenediaminetetraacetic acid, D-panthenol, p-hydroxyacetophenone, 1,2-hexanediol, citric acid, 1,3-butylene glycol, and NMN were mixed according to the formula amount and homogenized (homogenizer, homogenization for 15 minutes) to obtain a mixed solution;

[0065] S2: Add the formulated amount of plant extract to the mixed liquid and mix well to obtain the anti-hair loss and hair growth product.

[0066] Example 3,

[0067] A hair loss prevention and growth product, comprising the following raw materials in parts by weight: 80 parts of water, 5 parts of propylene glycol, 1 part of 1,2-pentanediol, 0.1 part of pyrrolidinopyrimidine oxide, 0.1 part of diaminopyrimidine oxide, 0.01 part of caffeine, 0.1 part of adenosine, 0.2 part of vitamin B6, 0.01 part of biotin tripeptide-1, 1 part of dipotassium glycyrrhizate, 0.02 part of ethylenediaminetetraacetic acid, 0.1 part of D-panthenol, 1 part of p-hydroxyacetophenone, 1 part of 1,2-hexanediol, 0.1 part of citric acid, 1 part of 1,3-butylene glycol, 1 part of NMN, and 5 parts of plant extracts;

[0068] The plant extract is a mixed extract of Ajuga sibiricum, Polygonum multiflorum (prepared), Platycladus orientalis leaves, mulberry leaves, licorice, Ligustrum lucidum fruit, ginseng, Notopterygium wilfordii and Angelica sinensis in a mass ratio of 10:1:1:1:1:1:1:1:1;

[0069] The extraction method of the plant extract comprises the following steps:

[0070] (1) After grinding and mixing Ajuga sibiricum, Radix Polygoni Multiflori, and Platycladus orientalis leaves in proportion, first add 5 times the weight of 60% ethanol aqueous solution, heat (50°C) and reflux for 6 hours, filter to obtain the first filtrate for standby use; add 3 times the weight of 60% ethanol aqueous solution to the filter residue, heat (50°C) and reflux for 4 hours, filter to obtain the second filtrate for standby use; add 2 times the weight of 60% ethanol aqueous solution to the filter residue, heat (50°C) and reflux for 4 hours, and mix the filtered filtrate with the first filtrate and the second filtrate to obtain the first crude extract;

[0071] After mulberry leaves, liquorice, glossy privet fruit, ginseng, notopterygium root and angelica root are crushed and mixed in proportion, 3 times the weight of 60% ethanol aqueous solution is added, heated (50°C) and refluxed for 6 hours, and filtered to obtain a first filtrate for later use; 2 times the weight of 60% ethanol aqueous solution is added to the filter residue, heated (50°C) and refluxed for 4 hours, and filtered to obtain a second filtrate for later use; 2 times the weight of 60% ethanol aqueous solution is added to the filter residue, heated (50°C) and refluxed for 4 hours, and the filtered filtrate is mixed with the first filtrate and the second filtrate to obtain a second crude extract;

[0072] (2) The first crude extract was concentrated under reduced pressure (vacuum degree 0.05 MPa, 60°C) to 0.6 times the weight of the raw material, and citric acid was added to adjust the pH value to 4. The mixture was allowed to stand at 4°C for 2 h, and the filtrate was filtered (suction filtered) to obtain the first refined extract;

[0073] The second crude extract was concentrated under reduced pressure (vacuum degree 0.05 MPa, 60°C) to 0.6 times the weight of the raw material, and then citric acid was added to adjust the pH value to 4. The extract was allowed to stand at 4°C for 2 hours, and the filtrate was filtered (suction filtration) to obtain the second refined extract.

[0074] (3) After adding 0.05 mol / L sodium hydrogen phosphate solution to the first extract to adjust the pH value to 7.0, petroleum ether with a boiling range of 60-70°C (0.1 times the volume of the first extract) was added for stirring and extraction. After standing for 3 hours to separate the layers, the lower aqueous solution was removed and concentrated under reduced pressure (vacuum degree 0.05 MPa, 50°C) to 7% of the weight of the raw material to obtain the first extract;

[0075] The second refined extract was concentrated under reduced pressure (vacuum degree 0.05 MPa, 50° C.) to 7% of the weight of the raw material to obtain a second extract;

[0076] (4) The first extract and the second extract are mixed uniformly in a volume ratio of 1:1 to obtain a plant extract.

[0077] The preparation method of the anti-hair loss and hair growth product is as follows:

[0078] S1: Water, propylene glycol, caffeine, 1,2-pentanediol, pyrrolidinopyrimidine oxide, diaminopyrimidine oxide, adenosine, vitamin B6, biotin tripeptide-1, dipotassium glycyrrhizate, ethylenediaminetetraacetic acid, D-panthenol, p-hydroxyacetophenone, 1,2-hexanediol, citric acid, 1,3-butylene glycol, and NMN were mixed according to the formula, and then homogenized and dispersed (homogenizer, homogenization for 10 minutes) to obtain a mixed solution;

[0079] S2: Add the formulated amount of plant extract to the mixed liquid and mix well to obtain the anti-hair loss and hair growth product.

[0080] Example 4,

[0081] A hair loss prevention and hair growth product, comprising the following raw materials in parts by weight: 65 parts of water, 8 parts of propylene glycol, 3 parts of 1,2-pentanediol, 0.5 parts of pyrrolidinopyrimidine oxide, 0.25 parts of diaminopyrimidine oxide, 0.015 parts of caffeine, 0.05 parts of adenosine, 0.1 parts of vitamin B6, 0.25 parts of biotin tripeptide-1, 0.5 parts of dipotassium glycyrrhizate, 0.035 parts of ethylenediaminetetraacetic acid, 0.5 parts of D-panthenol, 0.6 parts of p-hydroxyacetophenone, 0.5 parts of 1,2-hexanediol, 0.35 parts of citric acid, 1.5 parts of 1,3-butylene glycol, 0.5 parts of NMN, and 4 parts of plant extracts;

[0082] The plant extract is a mixed extract of Ajuga sibiricum, Polygonum multiflorum (prepared), Platycladus orientalis leaves, mulberry leaves, licorice, Ligustrum lucidum fruit, ginseng, Notopterygium wilfordii and Angelica sinensis in a mass ratio of 6:1:1:1:1:1:1:1:1;

[0083] The extraction method of the plant extract comprises the following steps:

[0084] (1) After grinding and mixing Ajuga sibiricum, Radix Polygoni Multiflori, and Platycladus orientalis leaves in proportion, first add 4 times the weight of 60% ethanol aqueous solution, heat (60°C) and reflux for 4 hours, filter to obtain the first filtrate for standby use; add 2 times the weight of 60% ethanol aqueous solution to the filter residue, heat (60°C) and reflux for 4 hours, filter to obtain the second filtrate for standby use; add 2 times the weight of 60% ethanol aqueous solution to the filter residue, heat (60°C) and reflux for 4 hours, and mix the filtered filtrate with the first filtrate and the second filtrate to obtain the first crude extract;

[0085] After crushing and mixing mulberry leaves, liquorice, glossy privet fruit, ginseng, notopterygium root and angelica according to the proportion, the mixture was heated (70°C) and refluxed for 6 hours using 5 times the mass of 60% ethanol aqueous solution, and the filtrate was filtered to obtain the second crude extract;

[0086] (2) The first crude extract was concentrated under reduced pressure (vacuum degree 0.05 MPa, temperature 50°C) to 0.5 times the weight of the raw material, and citric acid was added to adjust the pH value to 4.5. The mixture was allowed to stand at 3°C ​​for 1.5 hours, and the filtrate was filtered (suction filtered) to obtain the first refined extract;

[0087] The second crude extract was concentrated under reduced pressure (vacuum degree 0.05 MPa, temperature 70°C) to 0.4 times the weight of the raw material, and then citric acid was added to adjust the pH value to 5. The extract was allowed to stand at 2°C for 2 hours, and the filtrate was filtered (suction filtration) to obtain the second refined extract.

[0088] (3) After adding 0.075 mol / L sodium hydrogen phosphate solution to the first extract to adjust the pH value to 6.5, petroleum ether with a boiling range of 60-70°C (the amount added is 0.15 times the volume of the first extract) is added for stirring and extraction. After standing for 4 hours to separate the layers, the lower aqueous solution is removed and then concentrated under reduced pressure (vacuum degree 0.05 MPa, 50°C) to 6% of the weight of the raw material to obtain the first extract;

[0089] The second refined extract was concentrated under reduced pressure (vacuum degree 0.05 MPa, 60°C) to 6% of the weight of the raw material to obtain a second extract;

[0090] (4) The first extract and the second extract are mixed uniformly in a volume ratio of 1:1 to obtain a plant extract.

[0091] The preparation method of the anti-hair loss and hair growth product is as follows:

[0092] S1: Water, propylene glycol, caffeine, 1,2-pentanediol, pyrrolidinopyrimidine oxide, diaminopyrimidine oxide, adenosine, vitamin B6, biotin tripeptide-1, dipotassium glycyrrhizate, ethylenediaminetetraacetic acid, D-panthenol, p-hydroxyacetophenone, 1,2-hexanediol, citric acid, 1,3-butylene glycol, and NMN were mixed according to the formula, and then homogenized and dispersed (homogenizer, homogenization for 13 minutes) to obtain a mixed solution;

[0093] S2: Add the formulated amount of plant extract to the mixed liquid and mix well to obtain the anti-hair loss and hair growth product.

[0094] Comparative Example 1

[0095] A hair loss prevention and growth product, the raw material formula and preparation method are the same as those in Example 1, the only difference is that the extraction method of the plant extract is:

[0096] (1) Grind and mix Ajuga sibiricum, Radix Polygoni Multiflori, Platycladus orientalis leaves, mulberry leaves, licorice, glossy privet fruit, ginseng, Notopterygium wilfordii and angelica sinensis according to the proportion, first add 4 times the weight of 60% ethanol aqueous solution, heat (60℃) and reflux for 4 hours, filter to obtain the first filtrate for standby use; add 2 times the weight of 60% ethanol aqueous solution to the filter residue, heat (60℃) and reflux for 4 hours, filter to obtain the second filtrate for standby use; add 2 times the weight of 60% ethanol aqueous solution to the filter residue, heat (60℃) and reflux for 4 hours, and mix the filtered filtrate with the first filtrate and the second filtrate to obtain the crude extract;

[0097] (2) The crude extract was concentrated under reduced pressure (vacuum degree 0.05 MPa, temperature 50°C) to 0.5 times the weight of the raw material, and then citric acid was added to adjust the pH value to 4.5. The extract was allowed to stand at 3°C ​​for 1.5 hours, and the filtrate was filtered (suction filtered) to obtain the refined extract;

[0098] (3) After adding 0.075 mol / L sodium hydrogen phosphate solution to the extract to adjust the pH value to 6.5, petroleum ether with a boiling range of 60-70°C (the amount added is 0.15 times the volume of the extract) is added for stirring and extraction. After standing for 4 hours to separate the layers, the lower aqueous solution is taken and concentrated under reduced pressure (vacuum degree 0.05 MPa, 50°C) to 6% of the weight of the raw material to obtain the plant extract.

[0099] Comparative Example 2

[0100] A hair loss prevention and growth product, the raw material formula and preparation method are the same as those in Example 1, except that: in the plant extract extraction method step (2), the first crude extract is concentrated under reduced pressure to 0.8 times the weight of the raw material.

[0101] Comparative Example 3

[0102] A hair loss prevention and growth product, the raw material formula and preparation method are the same as those in Example 1, except that: in the plant extract extraction method step (2), the first crude extract is concentrated under reduced pressure to 0.3 times the weight of the raw material.

[0103] Comparative Example 4

[0104] A hair loss prevention and growth product, the raw material formula and preparation method are the same as those in Example 1, the only difference being that in step (2) of the plant extract extraction method, citric acid is added to the first crude extract to adjust the pH value to 3.5.

[0105] Comparative Example 5

[0106] A hair loss prevention and growth product, the raw material formula and preparation method are the same as those in Example 1, the only difference being that in step (2) of the plant extract extraction method, citric acid is added to the first crude extract to adjust the pH value to 6.0.

[0107] Comparative Example 6

[0108] A hair loss prevention and growth product, the raw material formula and preparation method are the same as those in Example 1, the only difference being that in step (2) of the plant extract extraction method, the first crude extract is allowed to stand at 5°C for 1.5 hours.

[0109] Comparative Example 7

[0110] A hair loss prevention and growth product, the raw material formula and preparation method are the same as those in Example 1, except that: in the plant extract extraction method step (2), the first crude extract is allowed to stand at 1°C for 1.5 hours.

[0111] Comparative Example 8

[0112] A hair loss prevention and growth product, the raw material formula and preparation method are the same as those in Example 1, except that: in step (3) of the plant extract extraction method, no sodium hydrogen phosphate solution is added to adjust the pH value.

[0113] Comparative Example 9

[0114] A hair loss prevention and growth product, the raw material formula and preparation method are the same as those in Example 1, except that: in the extraction method of the plant extract step (3), a sodium bicarbonate solution with a concentration of 0.075 mol / L is used to adjust the pH value to 6.5.

[0115] Comparative Example 10

[0116] A hair loss prevention and growth product, the raw material formula and preparation method are the same as those in Example 1, except that: in the extraction method of the plant extract step (3), a sodium hydrogen phosphate solution with a concentration of 0.075 mol / L is added to adjust the pH value to 7.5.

[0117] Comparative Example 11

[0118] A hair loss prevention and growth product, the raw material formula and preparation method are the same as those in Example 1, the only difference being that in step (3) of the plant extract extraction method, petroleum ether with a boiling range of 60-80°C is used for extraction.

[0119] Comparative Example 12

[0120] A hair loss prevention and growth product, the raw material formula and preparation method are the same as those in Example 1, the only difference being that in step (3) of the plant extract extraction method, petroleum ether with a boiling range of 30-60°C is used for extraction.

[0121] Comparative Example 13

[0122] A hair loss prevention and growth product, the raw material formula and preparation method are the same as those in Example 1, except that the extraction method of the plant extract comprises the following steps:

[0123] (1) After grinding and mixing Ajuga sibiricum, Radix Polygoni Multiflori, and Platycladus orientalis leaves in proportion, first add 4 times the weight of 60% ethanol aqueous solution, heat (60°C) and reflux for 4 hours, filter to obtain the first filtrate for standby use; add 2 times the weight of 60% ethanol aqueous solution to the filter residue, heat (60°C) and reflux for 4 hours, filter to obtain the second filtrate for standby use; add 2 times the weight of 60% ethanol aqueous solution to the filter residue, heat (60°C) and reflux for 4 hours, and mix the filtered filtrate with the first filtrate and the second filtrate to obtain the first crude extract;

[0124] After mulberry leaves, liquorice, glossy privet fruit, ginseng, notopterygium root and angelica root are crushed and mixed in proportion, 4 times the weight of 60% ethanol aqueous solution are added, heated (60°C) and refluxed for 4 hours, and filtered to obtain a first filtrate for use; 2 times the weight of 60% ethanol aqueous solution are added to the filter residue, heated (60°C) and refluxed for 4 hours, and filtered to obtain a second filtrate for use; 2 times the weight of 60% ethanol aqueous solution are added to the filter residue, heated (60°C) and refluxed for 4 hours, and the filtered filtrate is mixed with the first filtrate and the second filtrate to obtain a second crude extract;

[0125] (2) The first crude extract was concentrated under reduced pressure (vacuum degree 0.05 MPa, temperature 50°C) to 0.5 times the weight of the raw material, and then a 0.075 mol / L sodium hydrogen phosphate solution was added to adjust the pH value to 6.5. Then, petroleum ether with a boiling range of 60-70°C (the amount added was 0.15 times the volume of the first refined extract) was added for stirring and extraction. After standing for 4 hours to separate the layers, the lower aqueous solution was removed and concentrated under reduced pressure (vacuum degree 0.05 MPa, 50°C) to 6% of the weight of the raw material to obtain the first extract;

[0126] The second crude extract was concentrated under reduced pressure (vacuum degree 0.05 MPa, 50° C.) to 6% of the weight of the raw material to obtain a second extract;

[0127] (3) The first extract and the second extract are mixed uniformly in a volume ratio of 1:1 to obtain a plant extract.

[0128] Comparative Example 14

[0129] A hair loss prevention and growth product, the raw material formula and preparation method are the same as those in Example 1, except that the extraction method of the plant extract comprises the following steps:

[0130] (1) After grinding and mixing Ajuga sibiricum, Radix Polygoni Multiflori, and Platycladus orientalis leaves in proportion, first add 4 times the weight of 60% ethanol aqueous solution, heat (60°C) and reflux for 4 hours, filter to obtain the first filtrate for standby use; add 2 times the weight of 60% ethanol aqueous solution to the filter residue, heat (60°C) and reflux for 4 hours, filter to obtain the second filtrate for standby use; add 2 times the weight of 60% ethanol aqueous solution to the filter residue, heat (60°C) and reflux for 4 hours, and mix the filtered filtrate with the first filtrate and the second filtrate to obtain the first crude extract;

[0131] After mulberry leaves, liquorice, glossy privet fruit, ginseng, notopterygium root and angelica root are crushed and mixed in proportion, 4 times the weight of 60% ethanol aqueous solution are added, heated (60°C) and refluxed for 4 hours, and filtered to obtain a first filtrate for use; 2 times the weight of 60% ethanol aqueous solution are added to the filter residue, heated (60°C) and refluxed for 4 hours, and filtered to obtain a second filtrate for use; 2 times the weight of 60% ethanol aqueous solution are added to the filter residue, heated (60°C) and refluxed for 4 hours, and the filtered filtrate is mixed with the first filtrate and the second filtrate to obtain a second crude extract;

[0132] (2) The first crude extract was concentrated under reduced pressure (vacuum degree 0.05 MPa, temperature 50°C) to 0.5 times the weight of the raw material, and then citric acid was added to adjust the pH value to 4.5. The mixture was allowed to stand at 3°C ​​for 1.5 hours, and the filtrate was filtered (suction filtration) to obtain the first refined extract; the mixture was further concentrated under reduced pressure (vacuum degree 0.05 MPa, 50°C) to 6% of the weight of the raw material to obtain the first extract;

[0133] The second crude extract was concentrated under reduced pressure (vacuum degree 0.05 MPa, 50°C) to 0.5 times the weight of the raw material, and then citric acid was added to adjust the pH to 4.5. The extract was allowed to stand at 3°C ​​for 1.5 hours, and the filtrate was filtered (suction filtration) to obtain a second refined extract. The extract was further concentrated under reduced pressure (vacuum degree 0.05 MPa, 60°C) to 6% of the weight of the raw material to obtain a second extract.

[0134] (3) The first extract and the second extract are mixed uniformly in a volume ratio of 1:1 to obtain a plant extract.

[0135] Comparative Example 15

[0136] A hair loss prevention and growth product, the raw material formula and preparation method are the same as those in Example 1, except that the extraction method of the plant extract comprises the following steps:

[0137] (1) After grinding and mixing Ajuga sibiricum, Radix Polygoni Multiflori, and Platycladus orientalis leaves in proportion, first add 4 times the weight of 60% ethanol aqueous solution, heat (60°C) and reflux for 4 hours, filter to obtain the first filtrate for standby use; add 2 times the weight of 60% ethanol aqueous solution to the filter residue, heat (60°C) and reflux for 4 hours, filter to obtain the second filtrate for standby use; add 2 times the weight of 60% ethanol aqueous solution to the filter residue, heat (60°C) and reflux for 4 hours, and mix the filtered filtrate with the first filtrate and the second filtrate to obtain the first crude extract; concentrate the first crude extract under reduced pressure (vacuum degree 0.05MPa, temperature 50°C) to 6% of the weight of the raw material to obtain the first extract;

[0138] After mulberry leaves, licorice, glossy privet fruit, ginseng, notopterygium root and angelica root are crushed and mixed in proportion, 4 times the weight of 60% ethanol aqueous solution are added, heated (60°C) and refluxed for 4 hours, and filtered to obtain a first filtrate for standby use; 2 times the weight of 60% ethanol aqueous solution are added to the filter residue, heated (60°C) and refluxed for 4 hours, and filtered to obtain a second filtrate for standby use; 2 times the weight of 60% ethanol aqueous solution are added to the filter residue, heated (60°C) and refluxed for 4 hours, and the filtered filtrate is mixed with the first filtrate and the second filtrate to obtain a second crude extract, which is concentrated under reduced pressure (vacuum degree 0.05MPa, 50°C) to 6% of the weight of the raw material to obtain a second extract;

[0139] (2) The first extract and the second extract are mixed uniformly in a volume ratio of 1:1 to obtain a plant extract.

[0140] Experimental example

[0141] The plant extracts prepared in Examples 1-4 and Comparative Examples 1-15 were tested for color (visual colorimetry), odor (sensory grading method; a 6-person olfactory panel trained in ISO 8589 conducted a blind test in a sensory room at 20°C and 65% RH; scoring: 0 = no medicinal smell, 1 = very weak, 3 = perceptible, 5 = obvious, 7 = strong, 9 = very strong; the median was taken as the result), stilbene glycoside content (high performance liquid chromatography) and ginsenoside content (high performance liquid chromatography). The results are as follows:

[0142] Serial number Hazen Odor score Stilbene glycoside content (g / L) Ginsenoside content (g / L) Example 1 30 2.3 53.68 64.74 Example 2 30 2.5 51.57 63.57 Example 3 30 2.6 52.68 64.25 Example 4 30 2.8 50.49 65.36 Comparative Example 1 20 2.0 52.85 46.83 Comparative Example 2 60 2.3 55.39 64.36 Comparative Example 3 20 2.4 43.84 63.68 Comparative Example 4 20 2.2 46.83 64.36 Comparative Example 5 50 2.3 53.83 64.25 Comparative Example 6 60 2.4 54.82 63.62 Comparative Example 7 20 2.0 47.73 64.26 Comparative Example 8 30 2.3 41.68 64.38 Comparative Example 9 30 2.4 44.27 63.95 Comparative Example 10 30 2.3 46.93 64.08 Comparative Example 11 20 1.8 48.46 63.79 Comparative Example 12 30 3.8 51.26 64.85 Comparative Example 13 120 3.1 55.37 67.48 Comparative Example 14 30 5.5 54.24 64.15 Comparative Example 15 130 6.5 56.83 67.22

[0143] Analysis of the measurement results in the above table shows that the plant extracts in the anti-hair loss and hair growth products in Examples 1-4 of the present invention are targetedly processed using a specific extraction method. While ensuring the content of the active ingredient, the color and odor of the extracts are significantly reduced. As a result, the anti-hair loss and hair growth products containing the plant extracts have a lighter color and odor, are more easily accepted by consumers, and are conducive to the promotion and application of anti-hair loss and hair growth products.

[0144] In Comparative Example 1, since the grass raw materials were not processed separately according to the differences in their components, although the color and odor were lighter, some of the active ingredients in the raw materials were extracted and lost during the extraction process (especially when using petroleum ether for extraction), thereby significantly reducing the content of some active ingredients in the extract, which is not conducive to ensuring the corresponding effect of the hair growth liquid.

[0145] In Comparative Example 2, since the solvent content of the first crude extract after concentration is relatively high and the solute concentration is relatively low, the amount of precipitation of dark matter in an acidic and low-temperature environment is significantly reduced (which is not conducive to the separation and removal of dark matter). The content of dark matter in the first refined extract is large, and the color of the obtained plant extract is significantly darker.

[0146] In Comparative Example 3, since the solvent content of the first crude extract after concentration is low and the solute concentration is high, some active ingredients are also precipitated in an acidic and low-temperature environment and separated and removed together with the dark matter, thereby significantly reducing the content of some active ingredients in the plant extract, which is not conducive to ensuring the corresponding effect of the hair growth liquid.

[0147] In Comparative Example 4, when citric acid was used to adjust the pH value, the pH value was too low. Although it was beneficial to the precipitation of dark substances, it also caused some active ingredients to denature in an overly acidic environment, thereby significantly reducing the content of some active ingredients in the plant extract, which was not conducive to ensuring the corresponding effect of the hair growth liquid.

[0148] In Comparative Example 5, when citric acid was used to adjust the pH value, the pH value was too high, which was not conducive to the precipitation of dark substances, resulting in a significant decrease in the precipitation amount of dark substances in an acidic and low-temperature environment. The content of dark substances in the first refined extract was large, and the color of the obtained plant extract was significantly deepened.

[0149] In Comparative Example 6, the precipitation temperature is high, which is not conducive to the precipitation of dark substances, resulting in a significant decrease in the precipitation amount of dark substances in an acidic and low-temperature environment. The content of dark substances in the first refined extract is large, and the color of the obtained plant extract is significantly darker.

[0150] In Comparative Example 7, the precipitation temperature is too low. Although it is conducive to the precipitation of dark substances, it also causes some active ingredients to precipitate at too low a temperature and be separated and removed together with the dark substances, thereby significantly reducing the content of some active ingredients in the plant extract, which is not conducive to ensuring the corresponding effect of the hair growth liquid.

[0151] In Comparative Example 8, disodium hydrogen phosphate was not added as a stabilizer and the pH value was not adjusted. It is possible that it was not possible to complex with some active ingredients under the action of hydrogen bonds and phosphate groups to form a relatively stable substance (better solubility in water and insoluble in petroleum ether). As a result, when petroleum ether was used for extraction, some active ingredients would be extracted and lost by the petroleum ether, resulting in a significant reduction in the content of some active ingredients in the plant extract, which is not conducive to ensuring the corresponding effect of the hair growth liquid.

[0152] In Comparative Example 9, sodium bicarbonate is used as a pH regulator. Although the pH value is the same, it cannot form a relatively stable substance by complexation and cannot serve as a stabilizer. Therefore, when petroleum ether is used for extraction, some active ingredients will be extracted and lost by the petroleum ether, resulting in a significant reduction in the content of some active ingredients in the plant extract, which is not conducive to ensuring the corresponding effect of the hair growth liquid.

[0153] In Comparative Example 10, although disodium hydrogen phosphate was also used as a stabilizer and the pH value was adjusted, the pH value was too high, resulting in an alkaline environment. Some active ingredients were unable to form relatively stable substances under the action of hydrogen bonds and phosphate groups. Therefore, when petroleum ether was used for extraction, some active ingredients were extracted and lost by the petroleum ether, resulting in a significant reduction in the content of some active ingredients in the plant extract, which is not conducive to ensuring the corresponding effect of the hair growth liquid.

[0154] In Comparative Example 11, petroleum ether with a larger boiling range and higher boiling point is used as the extractant. Although the extraction and removal effect of odorous substances is better, it will also cause a small amount of effective ingredients to dissolve into the petroleum ether and be lost, resulting in a significant reduction in the content of some effective ingredients in the plant extract, which is not conducive to ensuring the corresponding effect of the hair growth liquid.

[0155] In Comparative Example 12, petroleum ether with a smaller boiling range was used as the extractant, which had a poor extraction effect on odorous substances, resulting in a significant increase in the content of odorous substances in the plant extract and a stronger odor.

[0156] In Comparative Example 13, precipitation treatment under low temperature and acidic conditions was not adopted to remove the dark substances in the extract, resulting in the extract containing a large amount of dark substances. At the same time, the large amount of dark substances further affected the subsequent extraction and removal of odorous substances, resulting in a significant increase in the odor and color of the obtained plant extract, which is not conducive to large-scale promotion and application.

[0157] In Comparative Example 14, the odor substances in the first extract were not specifically extracted and removed, resulting in a significant increase in the odor in the plant extract.

[0158] In Comparative Example 15, the dark substances and odor substances in the extract were not removed in a targeted manner, resulting in the plant extract having a strong odor and a dark color, which is not conducive to large-scale promotion and application.

[0159] It should be understood that the various forms of the processes shown above can be used to reorder, add, or delete steps. For example, the steps described in the present invention can be performed in parallel, sequentially, or in a different order, as long as the desired results of the technical solutions disclosed in the present invention can be achieved. This is not limited herein.

[0160] The above specific embodiments do not limit the scope of protection of the present invention. Those skilled in the art will appreciate that various modifications, combinations, sub-combinations, and substitutions may be made based on design requirements and other factors. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of the present invention are intended to be included within the scope of protection of the present invention.

Claims

1. A hair loss prevention and growth product containing plant extracts, comprising the following raw materials in parts by weight: 50-80 parts of water, 5-10 parts of propylene glycol, 1-5 parts of 1,2-pentanediol, 0.1-1 parts of pyrrolidino diaminopyrimidine oxide, 0.1-0.5 parts of diaminopyrimidine oxide, 0.01-0.02 parts of caffeine, 0.01-0.1 parts of adenosine, 0.05-0.2 parts of Vitamin B6, 0.01-0.5 parts of biotin tripeptide-1, 0.1-1 parts of dipotassium glycyrrhizate, 0.02-0.05 parts of ethylenediaminetetraacetic acid, 0.1-1 parts of D-panthenol, 0.2-1 parts of p-hydroxyacetophenone, 0.01-1 parts of 1,2-hexanediol, 0.1-0.5 parts of citric acid, 1-2 parts of 1,3-butylene glycol, 0.01-1 parts of NMN, 3-5 parts of plant extracts; in, The plant extract is a mixed extract of Ajuga strychnifolia, Polygonum multiflorum (prepared), Platycladus orientalis leaf, mulberry leaf, liquorice root, Ligustrum lucidum fruit, ginseng, Notopterygium wilfordii and Angelica sinensis; It is characterized in that the extraction method of the plant extract comprises the following steps: (1) Grinding and mixing Ajuga sibiricum, Radix Polygoni Multiflori, and Platycladus orientalis leaves in proportion, performing heating and refluxing extraction with 5-10 times the mass of 60% ethanol aqueous solution, and filtering the filtrate to obtain a first crude extract; After crushing and mixing mulberry leaves, licorice, glossy privet fruit, ginseng, notopterygium root and angelica according to proportion, heating and refluxing extraction was carried out with 5-10 times the mass of 60% ethanol aqueous solution, and the filtrate was filtered to obtain a second crude extract; (2) After concentrating the first crude extract to 0.4-0.6 times the weight of the raw material, add citric acid to adjust the pH to 4-5, and let it stand at 2-4°C for 1-2 hours. Filter the filtrate to obtain the first refined extract; After concentrating the second crude extract to 0.4-0.6 times the weight of the raw material, add citric acid to adjust the pH to 4-5, and let it stand at 2-4°C for 1-2 hours, filter the filtrate to obtain the second refined extract; (3) Adding 0.05-0.1 mol / L sodium hydrogen phosphate solution to the first refined extract to adjust the pH value to 6.5-7.0, then adding petroleum ether with a boiling range of 60-70°C for stirring and mixing extraction. After standing and stratification, remove the lower aqueous solution and concentrate it to 5-7% of the weight of the raw material to obtain the first extract; Concentrating the second refined extract to 5-7% of the weight of the raw material to obtain a second extract; (4) The first extract and the second extract are mixed uniformly in a volume ratio of 1:1 to obtain a plant extract.

2. The anti-hair loss and hair growth product containing plant extracts according to claim 1, characterized in that: The plant extract is obtained by extracting Ajuga strychnifolia, Radix Polygoni Multiflori, Platycladus orientalis leaves, mulberry leaves, licorice, Ligustrum lucidum fruit, ginseng, Notopterygium wilfordii and Angelica sinensis in a mass ratio of 5-10:1:1:1:1:1:1:1:1 as raw materials.

3. The anti-hair loss and hair growth product containing plant extracts according to claim 1, characterized in that: In the hair loss prevention and hair growth product, the weight ratio of pyrrolidino diaminopyrimidine oxide to diaminopyrimidine oxide is 2-3:

1.

4. The anti-hair loss and hair growth product containing plant extracts according to claim 1, characterized in that: In step (1), the temperature of the heating reflux extraction is not higher than 70° C., and the time is not less than 4 h.

5. The anti-hair loss and hair growth product containing plant extracts according to claim 1, characterized in that: In step (2), the first crude extract and the second crude extract are concentrated by a reduced pressure concentration method.

6. The anti-hair loss and hair growth product containing plant extracts according to claim 5, characterized in that: The temperature for concentrating the first crude extract under reduced pressure is not higher than 60°C; the temperature for concentrating the second crude extract under reduced pressure is not higher than 80°C.

7. The anti-hair loss and hair growth product containing plant extracts according to claim 1, characterized in that: In step (3), the amount of petroleum ether added is 0.1-0.2 times the volume of the first refined extract.

8. The anti-hair loss and hair growth product containing plant extracts according to claim 1, characterized in that: In step (3), the standing time after extraction is 3-5 hours.

9. A method for preparing the anti-hair loss and hair growth product containing plant extracts according to any one of claims 1 to 8, characterized in that: The steps include: S1: Mix water, propylene glycol, caffeine, 1,2-pentanediol, pyrrolidinopyrimidine oxide, diaminopyrimidine oxide, adenosine, vitamin B6, biotin tripeptide-1, dipotassium glycyrrhizate, ethylenediaminetetraacetic acid, D-panthenol, p-hydroxyacetophenone, 1,2-hexanediol, citric acid, 1,3-butylene glycol, and NMN according to the formula amount, and homogenize and disperse them to obtain a mixed solution; S2: Add the formulated amount of plant extract to the mixed liquid and mix well to obtain the anti-hair loss and hair growth product.

10. The method for preparing the anti-hair loss and hair growth product according to claim 9, characterized in that: In step S1, the homogenization and dispersion time is 10-15 minutes.