Hemostatic antibacterial medical gauze for buttocks

Abstract

The invention discloses hip hemostasis antibacterial medical gauze and a preparation method of the medical gauze, the hip hemostasis antibacterial medical gauze comprises a pasting layer, an adhesion layer and a functional layer, the adhesion layer is located in the middle, and the pasting layer and the functional layer are located on the two sides; the application layer is a polyurethane film, the functional layer is a gauze material which is formed by blending cotton fibers loaded with various active ingredients, natural bamboo fibers and fine denier chinlon, the adhesion layer is hydrogel, and the medical gauze is used for hemostasis of the surface of the hip, can be easily attached to the shape of a bulge of the hip and is not prone to sliding. The hemostatic bandage can be used for plugging type hemostasis and can also cope with strong pulling, secondary injury caused by wound adhesion is reduced, and the effects of rapid hemostasis and efficient bacteriostasis are achieved.

Description

Technical Field

[0001] The invention belongs to the field of medical gauze, and in particular relates to a hemostatic and antibacterial medical gauze for buttocks. Background Art

[0002] The buttocks are convex in shape, and ordinary bandages or gauze are easy to slide and cannot apply stable pressure. When the buttocks bleed, especially when the amount of bleeding is large, it is difficult to control the amount of bleeding by external pressure. The first reason is that because the buttocks muscles are hypertrophic, simple external force pressure cannot effectively transmit pressure to deep blood vessels. The second reason is that sometimes the cause of buttocks bleeding may be due to pelvic fracture, and retroperitoneal hematoma will further limit the compression effect.

[0003] To address the above issues, a general adhesive layer with edge adhesion can solve the problem of gauze sliding on the buttocks. However, the consequence of this is that it involves the damaged skin epidermis and has no restraint on the subcutaneous lining, which only treats the symptoms and not the root cause. At this time, a plug-in gauze strip is needed; existing gauze strips are generally made of pure cotton yarn, which has good blood absorption properties, but easily adhere to the inner wound, and there is a risk of secondary injury when replacing or removing them.

[0004] In order to be suitable for most usage scenarios, general medical gauze is often light and thin and can be torn to adapt to various wound areas and various bleeding situations. However, pure cotton medical gauze has large burrs after torn, and the pores of the cotton yarn are easily deformed, causing cotton wool and cotton scraps to be left in the wound, affecting the subsequent cleaning and medication.

[0005] Therefore, how to develop a hemostatic and antibacterial medical gauze for buttocks that has good physical and mechanical properties, strong adaptability, high antibacterial efficiency, prevents wound adhesion, and quickly stops bleeding has become a problem to be solved in the medical field.

[0006] This field urgently needs a bleeding treatment method suitable for buttocks wounds or unconventional, non-flat wounds, which can quickly stop bleeding and be antibacterial, and is suitable for general clinical and wartime scenarios. Summary of the Invention

[0007] In view of the shortcomings of the prior art, the present invention provides a hemostatic and antibacterial medical gauze for buttocks.

[0008] To achieve the above object, the present invention adopts the following technical solutions:

[0009] The hemostatic and antibacterial medical gauze for buttocks comprises a dressing layer, an adhesion layer and a functional layer, wherein the adhesion layer is in the middle and the dressing layer and the functional layer are on both sides; the dressing layer is a polyurethane film, the functional layer is a gauze material loaded with multiple active ingredients, and the adhesion layer is a hydrogel.

[0010] Preferably, the application layer - polyurethane film has the largest area, the functional layer - gauze material has the second largest area, and the adhesion layer - hydrogel has the smallest area.

[0011] Preferably, the multiple active ingredients coated by the gauze material are thrombin, antibiotics, chitosan, zeolite, and dispersant.

[0012] By adopting the above technical solution, the multi-layer medical gauze has tight bonds between the layers, and the uneven areas leave space for micro-changes after blood absorption, which does not affect the adhesion. Moreover, the gauze can be easily peeled off when needed, and the remaining parts are not easily damaged.

[0013] Preferably, the gauze material is a blended fabric, which specifically includes bamboo fiber, cotton fiber, and fine denier nylon, with a weight ratio of 0.1-0.3:1:0.5.

[0014] Preferably, the cotton fiber further comprises structural units introduced from the following monomers: hydroxyethyl methacrylate, 1-butyl-3-methylimidazolium chloride, and Exxelor VA 1801.

[0015] Wherein, the step of introducing the monomer into the cotton fiber is:

[0016] 1) Crush the absorbent cotton and dissolve it in a mixture of 1-butyl-3-methylimidazolium chloride ([BMIM]Cl) and dimethyl sulfoxide (DMSO) at 110°C for 120 minutes under inert gas. Cool the dissolved cellulose solution to room temperature and set aside. The mass ratio of cotton fiber to the mixed solvent is 1:100.

[0017] 2) Add 5-15 wt% HEMA monomer relative to the mass of cellulose to the cellulose / [BMIM]Cl solution and stir evenly; then add 0.5-1 wt% potassium persulfate (KPS) as a free radical initiator and 0.1-0.5 wt% sodium bisulfite as a reducing agent to form an oxidation-reduction initiation system. The mixture is reacted in a water bath at 60-80°C for 2-4 hours to graft the hydroxyethyl methacrylate (HEMA) onto the cellulose backbone;

[0018] 3) drying the grafted cellulose / [BMIM]Cl solution at 100° C. under vacuum for 24 hours to form a film; mixing the resulting cellulose film with 2-10 wt% of Exxelor VA 1801 relative to the weight of the cellulose; and melt-blending the mixture through a twin-screw extruder at a temperature of 180-220° C.; and granulating the mixture after extrusion to obtain the cotton fiber.

[0019] The yarn cloth material, i.e. the blended fabric, is obtained by the following preparation method:

[0020] 1) soaking bamboo strips in an alkaline degumming solution comprising 2-5% NaOH and 1-2% Na2CO3 by mass at 90°C for 2 hours; removing the bamboo strips, washing them with water until neutral, adding 0.5-1% silicone oil emulsion to soften them, and softening them at 50°C for 30 minutes to obtain bamboo fibers;

[0021] 2) Add 0.5% by weight of quaternary ammonium salt as an antistatic agent to 40°C warm water, evenly spray the nylon fiber, and simmer for 24 hours to obtain fine denier nylon. The humidity of the preparation environment should be controlled at 60-70% to prevent the fiber from absorbing moisture and agglomerating again;

[0022] 3) Finally, the yarn fabric is obtained through the process of blowing, carding, drawing and roving, spun yarn and winding, and needle punching;

[0023] Preferably, the dispersant is a nonionic surfactant, and the nonionic surfactant includes one of Tween 80 and polyethylene glycol 400.

[0024] By adopting the above technical solution, the nonionic surfactant is suitable for dispersing zeolite and antibiotics, and can also reduce interference with thrombin activity.

[0025] Preferably, the size of the zeolite is 200-300 mesh.

[0026] By adopting the above technical solution, such a size can balance the surface area and particle fixation, avoid the shedding of excessively fine particles or the induction of inflammation, while ensuring rapid water absorption and coagulation factor concentration; at the same time, under the action of the charge of the grafted 1-butyl-3-methylimidazolium chloride on the gauze material, the negatively charged zeolite can be assisted in dispersion.

[0027] The present invention also provides a method for preparing a buttocks hemostatic and antibacterial medical gauze, comprising the following steps:

[0028] 1) Hydroxyethyl methacrylate, 1-butyl-3-methylimidazolium chloride, and Exxelor VA 1801 were grafted onto cotton fibers respectively;

[0029] 2) blending the grafted cotton fiber with the treated bamboo fiber and fine-denier nylon to obtain yarn fabric;

[0030] 3) loading the gauze obtained in step 2) with active components;

[0031] 4) subjecting the loaded gauze material to a dipping-heat curing process and a deionized water rinse step to prepare a hydrogel-coated gauze material, wherein the heat curing process temperature is 120-130°C and the curing time is 1-2 hours;

[0032] 5) After removing excess adhesive from the hydrogel-coated gauze obtained in step 4), the gauze is turned over and placed, and the non-hydrogel gauze side is pressed with a polyurethane film, cut, adjusted to size, and packaged to obtain the hemostatic and antibacterial medical gauze for buttocks.

[0033] Preferably, the active component loading in step 3) is specifically a step-by-step loading, and the steps are as follows:

[0034] a. Dissolve chitosan in dilute acetic acid, add a crosslinking agent, impregnate the gauze material therein, and then neutralize and cure the chitosan coating on the gauze material;

[0035] b. The zeolite is then crushed and dispersed simultaneously with the antibiotic in an aqueous solution containing Tween to obtain a spray liquid, which is then sprayed on the gauze material and dried;

[0036] c. After adjusting the pH of the gauze surface to neutral, thrombin was loaded onto the gauze material by low-temperature spraying.

[0037] Furthermore, the thrombin concentration is 0.5-2 IU / cm², the coating thickness of the antibiotic is 0.5-2 mg / cm², the distribution density of the chitosan is 2-5 mg / cm², and the distribution density of the zeolite is 10-20 mg / cm².

[0038] By adopting the above technical solution, chitosan coating can enhance adhesion and hemostatic synergy; the mass of zeolite accounts for 15-30% of the total weight of gauze, ensuring hemostatic efficiency without affecting flexibility.

[0039] Preferably, the cross-linking agent is EDC or NHS; the size of the zeolite is 200-300 mesh; and the temperature of the low-temperature spraying method is 4°C.

[0040] Beneficial effects of the present invention:

[0041] 1) The blended gauze material combines the breathability of cotton, the antibacterial properties of bamboo fiber, and the ultra-fine fiber density of fine-denier nylon. This allows the blended gauze material to have better fineness and enhance its moisture absorption capacity on the basis of the advantages of traditional gauze. In addition, the fiber bending modulus of fine-denier nylon is low, which can fit the curves of the human body. For use on the surface of the buttocks, it can easily fit the convex shape of the buttocks and is not easy to slide. For plug-in hemostasis, it can also withstand strong pulling, so that it can be inserted accurately into place and can be withdrawn without residue when changing the dressing.

[0042] 2) Multi-layer medical gauze can be directly applied to the surface of general wounds when bleeding occurs. The gauze absorbs blood, and the moisture in the gauze activates the hydrogel in the middle to expand. Under the cover of the polyurethane film of the application layer, it slightly contracts inward, achieving the effect of adding pressure without causing secondary damage, making the wound area smaller, thereby achieving the purpose of reducing the amount of bleeding. In addition, the active substances loaded on the gauze can form a gel-like barrier, promoting platelet adhesion, and further accelerating hemostasis. More specifically, for deep wounds where the bleeding point cannot be confirmed, the gauze can be directly peeled off and inserted to stop bleeding. At the same time, the remaining part can be applied to the wound surface, and it can still slightly contract inward, achieving the purpose of reducing blood loss and quickly stopping bleeding.

[0043] 3) The grafted monomers and active substances work synergistically to maintain a stable loading state of the multilayer structure, ensuring that both direct application and gauze packing followed by reapplication have fast hemostasis rates, and can maintain antibacterial stability, reducing complications, while the material's air permeability and water absorption are not affected. BRIEF DESCRIPTION OF THE DRAWINGS

[0044] Figure 1 Schematic diagram of the hierarchical distribution of the medical gauze. DETAILED DESCRIPTION

[0045] The present invention is further described below by specific examples. In order to make the invention purpose, technical solution and beneficial technical effect of the present invention clearer, the present invention is further described in detail below with reference to the examples. It should be understood that the embodiments described in this specification are only for explaining the present invention and are not intended to limit the present invention.

[0046] Unless otherwise stated, all films and reagents used in the examples are commercially available or synthesized according to conventional methods and can be used directly without further treatment. The instruments used in the examples are also commercially available.

[0047] Experimental methods:

[0048] ① Carry out water absorption test, the reference standard is GB / T 21655.1-2008;

[0049] ② Bacterial filtration efficiency test, reference standard ASTM F2101;

[0050] ③Tensile strength test, reference standard GB / T 3923.1-2013;

[0051] ④Biocompatibility test, refer to the ISO 10993 cytotoxicity test standard.

[0052] ⑤ For the structure of multi-layer gauze, pull it in dry state and in wet state; compare the interfacial bonding force between the multi-layer structures in dry state, verify the feasibility of peeling off the gauze material, i.e. the functional layer, in the initial state, and observe the influence of the active substance load of the gauze material and the overall integrity; pulling in wet state simulates the application to bleeding wounds, verifies whether the medical gauze directly attached to the buttocks surface can resist the micro-expansion of hydrogel and layer displacement, verifies the overall tension contraction, the degree of adhesion to the wound epidermis, and micro-traction, so that it has a longitudinal compressive force that does not cause secondary damage to the wound, thereby reducing the amount of surface bleeding.

[0053] Example 1: Preparation of cotton fibers

[0054] 1) Crush the absorbent cotton and dissolve it in a mixture of 1-butyl-3-methylimidazolium chloride ([BMIM]Cl) and dimethyl sulfoxide (DMSO) at 110°C for 120 minutes under inert gas. Cool the dissolved cellulose solution to room temperature and set aside. The mass ratio of cotton fiber to the mixed solvent is 1:100.

[0055] 2) Add 5-15 wt% HEMA monomer relative to the mass of cellulose to the cellulose / [BMIM]Cl solution and stir evenly; then add 0.5-1 wt% potassium persulfate (KPS) as a free radical initiator and 0.1-0.5 wt% sodium bisulfite as a reducing agent to form an oxidation-reduction initiation system. The mixture is reacted in a water bath at 60-80°C for 2-4 hours to graft the hydroxyethyl methacrylate (HEMA) onto the cellulose backbone;

[0056] 3) drying the grafted cellulose / [BMIM]Cl solution at 100° C. under vacuum for 24 hours to form a film; mixing the resulting cellulose film with 2-10 wt% of Exxelor VA 1801 relative to the weight of the cellulose; and melt-blending the mixture through a twin-screw extruder at a temperature of 180-220° C.; and granulating the mixture after extrusion to obtain the cotton fiber.

[0057] Example 2: Processing of bamboo fiber and fine denier nylon

[0058] 1) soaking bamboo strips in an alkaline degumming solution comprising 2-5% NaOH and 1-2% Na2CO3 by mass at 90°C for 2 hours; removing the bamboo strips and washing them with water until neutral, then adding 0.5-1% silicone oil emulsion to soften them, and softening them at 50°C for 30 minutes to obtain bamboo fibers;

[0059] 2) Add 0.5% by weight of quaternary ammonium salt as an antistatic agent to 40°C warm water, evenly spray the nylon fiber, and simmer for 24 hours to obtain fine denier nylon. The humidity of the preparation environment should be controlled at 60-70% to prevent the fiber from absorbing moisture and agglomerating again;

[0060] Example 3: Blending

[0061] The yarn fabric is obtained through the process of blow room, carding, drawing and roving, spun yarn and winding, and needle punching, specifically:

[0062] 1) Blowing process:

[0063] First, use A002 plucker → FA035C mixed cotton opener → FA106 cotton opener to feed mixed fibers according to the dry weight ratio of bamboo fiber, cotton fiber and fine denier nylon of 0.2:1:0.5;

[0064] Beat lightly at a low speed of 300-500 r / min to avoid fiber damage; the workshop humidity is controlled at 60-70% to reduce static electricity.

[0065] 2) Carding process:

[0066] Then, the FA226A carding machine is used, with the spacing between the cylinder and the cover plate being 8-7 inches and the sliver delivery speed being 90m / min, to reduce the friction damage of the bamboo fiber and ensure that the fiber is fully combed;

[0067] 3) Drawing and roving:

[0068] Then, the FA320 draw frame with autoleveling and the FA493 roving frame are used to optimize the fiber arrangement direction and reduce neps;

[0069] 4) Spinning and winding:

[0070] Then, 14.7tex yarn is spun using a TH518 spinning frame and wound on a Murata winder to ensure yarn uniformity.

[0071] 5) Acupuncture:

[0072] Finally, needle punching was used to control the hot melt temperature to 130-140°C, which is the softening point of Exxelor VA 1801, to avoid damaging the cotton fibers; thus, a gauze fabric was obtained.

[0073] Example 4: Gauze material loaded with active substances

[0074] Step-by-step loading, the steps are as follows:

[0075] a. Dissolve chitosan in dilute acetic acid to a pH of 4-4.5, add the crosslinking agent EDC (1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride), impregnate the gauze material therein, neutralize and cure, and coat the chitosan on the gauze material;

[0076] b. The zeolite was then crushed to 220 mesh and dispersed simultaneously with gentamicin in an aqueous solution containing Tween 80 to obtain a spray liquid, which was then sprayed on the gauze material and dried;

[0077] c. After adding a dilute alkali solution to adjust the pH of the gauze surface to neutral, thrombin was loaded onto the gauze material by a low-temperature spray method at 4°C.

[0078] The loading amounts of the active substances are as follows: the thrombin concentration is 1.5 IU / cm², the coating thickness of the antibiotic is 2 mg / cm², the distribution density of the chitosan is 3 mg / cm², and the distribution density of the zeolite is 15 mg / cm².

[0079] Example 5: Multi-layer assembly

[0080] The loaded gauze material is subjected to a dipping-heat curing process and a deionized water rinsing step to prepare a gauze material modified with a hydrogel coating, wherein the temperature of the heat curing process is 120-130° C. and the curing time is 1-2 hours;

[0081] After removing excess adhesive from the gauze material modified with the hydrogel coating obtained in the previous step, the gauze material is turned over and placed, and the non-gauze side of the hydrogel material is pressed with a polyurethane film, cut, adjusted in size, and packaged to obtain the hemostatic and antibacterial medical gauze for the buttocks.

[0082] Example 6: Adjust the conditions in Example 4 and keep the rest unchanged

[0083] Step-by-step loading, the steps are as follows:

[0084] a. The chitosan was dissolved in dilute acetic acid, pH 4-4.5, and a crosslinking agent NHS (N-hydroxysuccinimide) was added. The gauze was impregnated therein and then neutralized and cured, and the chitosan coating was applied to the gauze;

[0085] b. The zeolite was then crushed to 250 mesh and dispersed simultaneously with vancomycin in an aqueous solution containing polyethylene glycol 400 to obtain a spray solution, which was then sprayed on the gauze material and dried;

[0086] c. After adding a dilute alkali solution to adjust the pH of the gauze surface to neutral, thrombin was loaded onto the gauze material by a low-temperature spray method at 4°C.

[0087] The loading amounts of the active substances are as follows: the thrombin concentration is 2 IU / cm², the coating thickness of the antibiotic is 0.5 mg / cm², the distribution density of the chitosan is 5 mg / cm², and the distribution density of the zeolite is 10 mg / cm².

[0088] Example 7: Adjust the conditions in Example 4 and keep the rest unchanged

[0089] The zeolite was crushed into 300 mesh and dispersed in an aqueous solution containing Tween 80 together with gentamicin;

[0090] The loading amounts of the active substances are as follows: the thrombin concentration is 0.5 IU / cm², the coating thickness of the antibiotic is 1.2 mg / cm², the distribution density of the chitosan is 2 mg / cm², and the distribution density of the zeolite is 20 mg / cm².

[0091] Example 8: Adjust the conditions in Example 3 and keep the rest unchanged

[0092] The mixed fibers are added according to the dry weight ratio of bamboo fiber, cotton fiber and fine denier nylon of 0.1:1:0.5.

[0093] Example 9: Adjust the conditions in Example 3 and keep the rest unchanged

[0094] The mixed fibers are added according to the dry weight ratio of bamboo fiber, cotton fiber and fine denier nylon of 0.3:1:0.5.

[0095] The grafted yarn material was tested in experimental methods ①-④, involving Example 3.8.9. The results are shown in the following table:

[0096] Water absorption Bacterial Filtration Efficiency tensile strength Biocompatibility Example 3 24.33 seconds ≥99.9% Warp ≥15N / cm, weft ≥12N / cm No cytotoxic reaction Example 8 25.74 seconds ≥99.9% Warp ≥15N / cm, weft ≥12N / cm No cytotoxic reaction Example 9 23.12 seconds ≥99.9% Warp ≥15N / cm, weft ≥12N / cm No cytotoxic reaction

[0097] As can be seen from the table, the gauze material in the above embodiment has the advantages of good water absorption, good antibacterial effect, ability to be peeled without damaging the integrity, and good biocompatibility;

[0098] Verification of experimental method ⑤ of Example 5.6.7 was performed, including:

[0099] 1. Dry state test: Use an INSTRON 5967 material testing machine equipped with a 500N sensor, a tensile rate of 10mm / min, and record the elastic modulus in the 0-5% strain range. The peel test uses a modified T-type peeling fixture with a peel angle of 175±5°.

[0100] 2. Wet state simulation: Prepare simulated wound exudate (PBS containing 5% fetal bovine serum) and pre-soak in a gradient of 5 min → 15 min → 30 min in three stages. Maintain a constant temperature and humidity chamber at 37°C (RH ≥ 95%) during testing.

[0101] 3. Quantitative analysis of interfacial binding force - binding energy test: A surface force instrument (SFA) was used to measure the cotton-hydrogel interfacial binding energy, with a contact time gradient of 10s→30s→60s.

[0102] Hydrogel and polyurethane film Fit Hydrogel and gauze Completeness Example 5 18J / m² Perfect fit 8J / m² whole Example 6 15J / m² Perfect fit 10J / m² whole Example 7 14J / m² Perfect fit 6J / m² whole

[0103] The results of the above examples show that under dry conditions, the binding energy between the hydrogel and the polyurethane film is greater than that of the gauze strip, it is easy to peel off and intact, the loaded active substance is not affected by peeling, and the deformation of the hydrogel in the wet state due to water absorption does not affect the overall fit.

[0104] In summary, the present invention provides a medical gauze that can fit the curves of the human body and is used for hemostasis on the buttocks surface. It can easily fit the convex shape of the buttocks and is not easy to slide. It can be used for plug-in hemostasis, and can also cope with strong pulling, reduce secondary damage caused by wound adhesion, and achieve the effect of rapid hemostasis and efficient antibacterial.

Claims

1. A hemostatic and antibacterial medical gauze for buttocks, characterized in that: Prepared by the following preparation method: 1) Hydroxyethyl methacrylate, 1-butyl-3-methylimidazolium chloride, and Exxelor VA 1801 were grafted onto cotton fibers respectively; 2) blending the grafted cotton fibers obtained in step 1) with the treated bamboo fibers and fine-denier nylon to obtain a yarn fabric; 3) loading the gauze obtained in step 2) with active components; 4) subjecting the gauze material loaded in step 3) to a dipping-heat curing process and a deionized water rinsing step to prepare a gauze material modified with a hydrogel coating; 5) removing excess adhesive from the hydrogel-coated gauze obtained in step 4), turning the gauze over, laminating the hydrogel-free side with a polyurethane film, cutting, adjusting the size, and packaging to obtain the hemostatic and antibacterial medical gauze for buttocks; The hemostatic and antibacterial medical gauze for buttocks includes a dressing layer, an adhesion layer and a functional layer, wherein the adhesion layer is in the middle, and the dressing layer and the functional layer are on both sides; the dressing layer is a polyurethane film, the functional layer is a gauze material loaded with active ingredients, and the adhesion layer is a hydrogel.

2. The hemostatic and antibacterial medical gauze for buttocks according to claim 1, characterized in that: The active ingredients loaded on the gauze material are thrombin, antibiotics, chitosan, zeolite and dispersant.

3. The hemostatic and antibacterial medical gauze for buttocks according to claim 2, characterized in that: The yarn cloth material is a blended fabric, which includes bamboo fiber, cotton fiber and fine denier nylon, with a weight ratio of 0.1-0.3:1:0.

5.

4. The hemostatic and antibacterial medical gauze for buttocks according to claim 3, characterized in that: The cotton fiber further comprises structural units introduced from the following monomers: hydroxyethyl methacrylate, 1-butyl-3-methylimidazolium chloride, and Exxelor VA1801.

5. The hemostatic and antibacterial medical gauze for buttocks according to claim 2, characterized in that: The dispersant is a nonionic surfactant, and the nonionic surfactant includes one of Tween 80 and polyethylene glycol 400.

6. The hemostatic and antibacterial medical gauze for buttocks according to claim 2, characterized in that: The antibiotic is one of gentamicin or vancomycin.

7. The hemostatic and antibacterial medical gauze for buttocks according to claim 1, characterized in that: The step 3) active component loading is specifically a step-by-step loading, and the steps are as follows: a. Dissolve chitosan in dilute acetic acid, add a crosslinking agent, impregnate the gauze material therein, neutralize and cure, and coat the chitosan on the gauze material; b. The zeolite is then crushed and dispersed simultaneously with the antibiotic in an aqueous solution containing Tween to obtain a spray liquid, which is then sprayed on the gauze material and dried; c. After adjusting the pH of the gauze surface to neutral, thrombin was loaded onto the gauze material by low-temperature spraying.

8. The hemostatic and antibacterial medical gauze for buttocks according to claim 7, characterized in that: The cross-linking agent is EDC or NHS; the size of the zeolite is 200-300 mesh; and the temperature of the low-temperature spraying method is 4°C.

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