Sweet-scented osmanthus lipstick for preventing and treating cheilitis and fading cheilogramma

Abstract

The invention belongs to the technical field of biological pharmacy, and particularly relates to a sweet osmanthus lipstick for preventing and treating cheilitis and fading cheilogramma. In the composition disclosed by the invention, the osmanthus fragrans extract can reduce transcription of proinflammatory factors by inhibiting two signal channels of NF-kB and AP-1, so that generation of inflammatory mediators is reduced; the bisabolol has remarkable anti-inflammatory and soothing effects and can effectively relieve inflammation symptoms such as red and swollen lips and pain. The radix arnebiae seu lithospermi extract has the effects of clearing away heat and toxic materials and cooling and activating blood, and further enhances the anti-inflammatory effect. Phytosphingosine can promote repair and regeneration of lip cells and accelerate healing of damaged lip skin.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of biological medicine, and particularly relates to a osmanthus lip balm for preventing and treating cheilitis and lightening lip lines. BACKGROUND

[0002] The skin of the lips is one of the thinnest and most sensitive parts of the human body, and is easily affected by external environmental factors and bad living habits, resulting in problems such as cheilitis, dryness, peeling, and lip lines. Cheilitis is a common lip disease, which is characterized by redness, itching, pain, scaling, and cracking of the lips, and seriously affects the daily life and appearance of patients. The appearance of dry lips and lip lines not only affects the appearance of the lips, but also can cause aging and damage to the skin of the lips. Existing products for preventing and treating cheilitis are mainly based on chemical drugs, which can alleviate symptoms in the short term, but long-term use can cause side effects such as skin dependence, pigmentation, and skin atrophy.

[0003] In addition, in addition to cheilitis, many factors can cause lip lines. Physiologically, the skin structure of the lips is special, with thin skin and a lack of sweat glands and sebaceous glands, making it prone to lines due to water loss, loss of collagen, and frequent muscle activity. Environmentally, dry climates and ultraviolet radiation can accelerate water loss and aging of the skin, leading to deeper lip lines. In addition, bad habits such as licking the lips, smoking, and using improper lip care products can also damage the skin barrier of the lips, irritate the skin, and make lip lines more noticeable.

[0004] Although there are many types of lip balm products on the market, there are still limitations in terms of relieving cheilitis, moisturizing, and lightening lip lines. Most lip balms have single ingredients, which cannot effectively relieve cheilitis symptoms, and may even exacerbate lip inflammation due to the presence of irritating ingredients. In addition, although some lip balms have a certain moisturizing effect, the moisturizing time is short, which cannot meet the needs of consumers for long-lasting moisturization. For lip line problems, the lightening effect of existing lip balms is not significant, and most products lack targeted repair ingredients. Therefore, it is particularly urgent to develop a product that can prevent and treat cheilitis and lighten lip lines. SUMMARY

[0005] The purpose of the present application is to provide a product that can effectively prevent and treat cheilitis, which is green and safe, and has the effect of lightening lip lines while preventing and treating cheilitis.

[0006] The present application provides a composition for preventing and treating cheilitis, which comprises the following ingredients in parts by mass: osmanthus extract 1-5 parts, arnebia extract 1-5 parts, farnesol 1-5 parts, plant sphingosine 1-3 parts, and VB 0.1-1 part.

[0007] Preferably, the Osmanthus fragrans extract is an ethyl acetate extract of Osmanthus fragrans or an alcohol extract of Osmanthus fragrans; the Arnebia euchroma extract is an ethyl acetate extract of Arnebia euchroma or an alcohol extract of Arnebia euchroma. The preparation method of the alcohol extract of Osmanthus fragrans preferably comprises the following steps: mixing fresh Osmanthus fragrans with 60%-75% ethanol according to a solid-liquid ratio of 1g: 15-25mL, performing ultrasonic-assisted extraction at 45-60°C for 25-45min, and then removing the excess solvent by concentration under reduced pressure to obtain the alcohol extract of Osmanthus fragrans. The preparation method of the ethyl acetate extract of Osmanthus fragrans preferably comprises the following steps: mixing fresh Osmanthus fragrans with ethyl acetate according to a solid-liquid ratio of 1g: 10-15mL, performing ultrasonic-assisted extraction at 45-50°C for 30-45min, and then removing the excess solvent by concentration under reduced pressure to obtain the ethyl acetate extract of Osmanthus fragrans. The preparation method of the alcohol extract of Arnebia euchroma preferably comprises the following steps: crushing dried Arnebia euchroma, mixing the crushed Arnebia euchroma with 60%-75% ethanol according to a solid-liquid ratio of 1g: 10-15mL, performing ultrasonic-assisted extraction at 45-55°C for 25-45min, and then removing the excess solvent by concentration under reduced pressure to obtain the alcohol extract of Arnebia euchroma. The preparation method of the ethyl acetate extract of Arnebia euchroma preferably comprises the following steps: crushing dried Arnebia euchroma, mixing the crushed Arnebia euchroma with ethyl acetate according to a solid-liquid ratio of 1g: 10-15mL, performing ultrasonic-assisted extraction at 45-50°C for 30-60min, and then removing the excess solvent by concentration under reduced pressure to obtain the ethyl acetate extract of Arnebia euchroma.

[0008] The application further provides application of the composition in the preparation of products for preventing and treating cheilitis and lightening lip lines.

[0009] The application further provides an Osmanthus fragrans lip balm for preventing and treating cheilitis and lightening lip lines, which comprises the following components in mass parts: 5-10 parts of the composition, 5-15 parts of sunflower wax, 5-12 parts of candelilla wax, 8-15 parts of natural beeswax, 10-20 parts of cocoa butter, 5-15 parts of shea butter, 5-10 parts of squalane, 5-15 parts of isononyl isononanoate and 0.2-2 parts of VE.

[0010] The application further provides a preparation method of the lip balm, which comprises the following steps: The composition is uniformly mixed, the sunflower wax, the candelilla wax, the natural beeswax, the cocoa butter, the shea butter, the squalane and the isononyl isononanoate are heated to be melted, and then the composition and the VE are added and uniformly dispersed, and the heating is stopped, and the mixture is poured into a mold to obtain the lip balm after cooling.

[0011] Preferably, the heating temperature is 60-70°C.

[0012] Preferably, the uniform dispersion condition is stirring at 40-80 rpm for 15-30 min.

[0013] Advantages of the present application: In the composition of the present application, the osmanthus extract can reduce the generation of inflammatory mediators by inhibiting the transcription of pro-inflammatory factors through two signal pathways of NF-κB and AP-1; the farnesol has significant anti-inflammatory and soothing effects, and can effectively relieve inflammation symptoms such as swelling and pain of the lips; the radix lithospermi extract has the effects of clearing heat and detoxifying, cooling blood and activating blood, and further enhances the anti-inflammatory effect; and the phytosphingosine can promote the repair and regeneration of the lip cells and accelerate the healing of the damaged lip skin.

[0014] All the components in the composition and the lip balm of the present application are of natural origin, have no irritation, are suitable for long-term use, and are especially suitable for people with sensitive skin. The osmanthus extract and the radix lithospermi extract and other natural ingredients not only have good effects, but also endow the product with a unique natural fragrance, thereby improving the use experience.

[0015] The lip balm of the present application does not add any chemical preservatives, fragrances or pigments in the preparation process, thereby avoiding the irritation of chemical components to the lip skin and reducing the risk of allergic reactions.

[0016] The preparation process adopted in the present application can ensure the stability of the active ingredients. The heating temperature and the stirring speed are strictly controlled in the preparation process, so as to ensure the bioavailability of the active ingredients, make them be better absorbed by the lip skin, and play the effects of anti-inflammation, repair and moisturization.

[0017] The lip balm product provided by the present application also has good moisturizing performance, and has the effects of moisturizing, moisturizing, and lightening lip lines while preventing and treating cheilitis. The osmanthus extract and the shea butter and other components have good moisturizing performance, can effectively lock the moisture of the lips, and prevent the lips from drying and desquamating. The squalane and isononyl isononanoate and other oil components can form a protective film on the lips, thereby further enhancing the moisturizing effect. The antioxidant components in the osmanthus extract and the phytosphingosine can promote the metabolism of the lip skin, reduce pigmentation, lighten the lip lines, and improve the overall appearance of the lips. DETAILED DESCRIPTION

[0018] In order to further illustrate the present application, the schemes provided by the present application are described in detail below in combination with examples, but they should not be understood as limiting the protection scope of the present application.

[0019] Example 1 Fresh osmanthus was washed and dried, then mixed with 75% ethanol according to the solid-liquid ratio of 1g:15mL, and extracted under the condition of 60℃ and 200W ultrasonic assistance for 35min, and then the excess solvent was removed by reduced pressure concentration to obtain the osmanthus alcohol extract for standby.

[0020] The dried Radix Lithospermi was crushed and passed through a 60-mesh sieve, then mixed with 60% ethanol at a solid-liquid ratio of 1 g:10 mL, and extracted for 40 min under the condition of 45-55°C with the assistance of 200-300 W ultrasonic. The excess solvent was removed by concentration under reduced pressure to obtain Radix Lithospermi ethanol extract for later use.

[0021] The 2 parts of magnolia ethanol extract, 2 parts of Radix Lithospermi ethanol extract, 1 part of farnesol, 1.8 parts of phytosphingosine, and 0.2 parts of VB were uniformly mixed to obtain a composition.

[0022] Example 2 The fresh magnolia was washed and dried, then mixed with 75% ethanol at a solid-liquid ratio of 1 g:15 mL and extracted for 35 min under the condition of 60°C with the assistance of 200 W ultrasonic. The excess solvent was removed by concentration under reduced pressure to obtain magnolia ethanol extract for later use.

[0023] The dried Radix Lithospermi was crushed and passed through a 60-mesh sieve, then mixed with 60% ethanol at a solid-liquid ratio of 1 g:10 mL, and extracted for 40 min under the condition of 45-55°C with the assistance of 200-300 W ultrasonic. The excess solvent was removed by concentration under reduced pressure to obtain Radix Lithospermi ethanol extract for later use.

[0024] The 3 parts of magnolia ethanol extract, 2 parts of Radix Lithospermi ethanol extract, 1 part of farnesol, 1.2 parts of phytosphingosine, and 0.8 parts of VB were uniformly mixed to obtain a composition.

[0025] Example 3 The fresh magnolia was washed and dried, then mixed with 75% ethanol at a solid-liquid ratio of 1 g:15 mL and extracted for 35 min under the condition of 60°C with the assistance of 200 W ultrasonic. The excess solvent was removed by concentration under reduced pressure to obtain magnolia ethanol extract for later use.

[0026] The dried Radix Lithospermi was crushed and passed through a 60-mesh sieve, then mixed with 60% ethanol at a solid-liquid ratio of 1 g:10 mL, and extracted for 40 min under the condition of 45-55°C with the assistance of 200-300 W ultrasonic. The excess solvent was removed by concentration under reduced pressure to obtain Radix Lithospermi ethanol extract for later use.

[0027] The 3 parts of magnolia ethanol extract, 2 parts of Radix Lithospermi ethanol extract, 2 parts of farnesol, 2.5 parts of phytosphingosine, and 0.5 parts of VB were uniformly mixed to obtain a composition.

[0028] Example 4 The fresh magnolia was washed and dried, then mixed with ethyl acetate at a solid-liquid ratio of 1 g:15 mL and extracted for 45 min under the condition of 45°C with the assistance of 400 W ultrasonic. The excess solvent was removed by concentration under reduced pressure to obtain magnolia ethyl acetate extract for later use.

[0029] The dried comfrey was crushed and passed through a 60-mesh sieve, then mixed with ethyl acetate at a solid-liquid ratio of 1 g: 10 mL, and extracted for 30 min at 50°C with the assistance of 600W ultrasonic. The excess solvent was removed by concentration under reduced pressure to obtain the comfrey ethyl acetate extract.

[0030] The following ingredients were mixed uniformly in parts by mass: 4 parts of the osmanthus fragrans ethyl acetate extract, 1 part of the comfrey ethyl acetate extract, 1 part of farnesol, 1 part of phytosphingosine, and 1 part of VB to obtain a composition.

[0031] Comparative Example 1 The difference from Example 1 is that phytosphingosine is not used.

[0032] The fresh osmanthus fragrans was washed and dried, then mixed with 75% ethanol at a solid-liquid ratio of 1 g: 15 mL, and extracted for 35 min at 60°C with the assistance of 200W ultrasonic. The excess solvent was removed by concentration under reduced pressure to obtain the osmanthus fragrans ethanol extract for later use.

[0033] The dried comfrey was crushed and passed through a 60-mesh sieve, then mixed with 60% ethanol at a solid-liquid ratio of 1 g: 10 mL, and extracted for 40 min at 45-55°C with the assistance of 200-300W ultrasonic. The excess solvent was removed by concentration under reduced pressure to obtain the comfrey ethanol extract for later use.

[0034] The following ingredients were mixed uniformly in parts by mass: 2 parts of the osmanthus fragrans ethanol extract, 2 parts of the comfrey ethanol extract, 2.8 parts of farnesol, and 0.2 parts of VB to obtain a composition.

[0035] Comparative Example 2 The difference from Example 1 is that the comfrey extract is not used.

[0036] The fresh osmanthus fragrans was washed and dried, then mixed with 75% ethanol at a solid-liquid ratio of 1 g: 15 mL, and extracted for 35 min at 60°C with the assistance of 200W ultrasonic. The excess solvent was removed by concentration under reduced pressure to obtain the osmanthus fragrans ethanol extract for later use.

[0037] The following ingredients were mixed uniformly in parts by mass: 4 parts of the osmanthus fragrans ethanol extract, 1 part of farnesol, 1.8 parts of phytosphingosine, and 0.2 parts of VB to obtain a composition.

[0038] Comparative Example 3 The difference from Example 1 is that the osmanthus fragrans extract is not used.

[0039] The dried comfrey was crushed and passed through a 60-mesh sieve, then mixed with 60% ethanol at a solid-liquid ratio of 1 g: 10 mL, and extracted for 40 min at 45-55°C with the assistance of 200-300W ultrasonic. The excess solvent was removed by concentration under reduced pressure to obtain the comfrey ethanol extract for later use.

[0040] Take 4 parts of the extract of Arnebia euchroma, 1 part of farnesol, 1.8 parts of phytosphingosine and 0.2 parts of VB, mix them evenly to obtain a composition.

[0041] Example 5 Take 7 g of the composition prepared in Example 1, 10 g of sunflower wax, 8 g of candelilla wax, 12 g of natural beeswax, 15 g of cocoa butter, 10 g of shea butter, 8 g of squalane, 12 g of isononyl isononanoate and 1 g of VE.

[0042] Mix the composition evenly; heat the sunflower wax, candelilla wax, natural beeswax, cocoa butter, shea butter, squalane and isononyl isononanoate to melt at 60°C, stir at 40 rpm for 10 min, after stirring evenly, add the composition and VE, stir at 60 rpm for 15 min, then stop heating, pour it into a mold, and after cooling, obtain a lipstick.

[0043] Example 6 Take 8 g of the composition prepared in Example 2, 8 g of sunflower wax, 10 g of candelilla wax, 12 g of natural beeswax, 15 g of cocoa butter, 10 g of shea butter, 7 g of squalane, 12 g of isononyl isononanoate and 1 g of VE.

[0044] Mix the composition evenly; heat the sunflower wax, candelilla wax, natural beeswax, cocoa butter, shea butter, squalane and isononyl isononanoate to melt at 65°C, stir at 40 rpm for 10 min, after stirring evenly, add the composition and VE, stir at 60 rpm for 15 min, then stop heating, pour it into a mold, and after cooling, obtain a lipstick.

[0045] Example 7 Take 10 g of the composition prepared in Example 3, 8 g of sunflower wax, 10 g of candelilla wax, 15 g of natural beeswax, 15 g of cocoa butter, 10 g of shea butter, 7 g of squalane, 12 g of isononyl isononanoate and 1 g of VE.

[0046] Mix the composition evenly; heat the sunflower wax, candelilla wax, natural beeswax, cocoa butter, shea butter, squalane and isononyl isononanoate to melt at 60°C, stir at 40 rpm for 10 min, after stirring evenly, add the composition and VE, stir at 50 rpm for 15 min, then stop heating, pour it into a mold, and after cooling, obtain a lipstick.

[0047] Comparative Example 4 Take 7 g of the composition prepared in Comparative Example 1, 10 g of sunflower wax, 8 g of candelilla wax, 12 g of natural beeswax, 15 g of cocoa butter, 10 g of shea butter, 8 g of squalane, 12 g of isononyl isononanoate and 1 g of VE.

[0048] The composition is mixed evenly; the sunflower wax, candelilla wax, natural beeswax, cocoa butter, shea butter, squalane and isononyl isononanoate are heated to 60°C to melt, stirred at 40 rpm for 10 min, after stirring evenly, the composition and VE are added, stirred at 60 rpm for 15 min, then stop heating, pour it into the mold, after cooling to get lip balm.

[0049] Comparative Example 5 Take the composition prepared in Comparative Example 2 7g, sunflower wax 10g, candelilla wax 8g, natural beeswax 12g, cocoa butter 15g, shea butter 10g, squalane 8g, isononyl isononanoate 12g, VE 1g.

[0050] The composition is mixed evenly; the sunflower wax, candelilla wax, natural beeswax, cocoa butter, shea butter, squalane and isononyl isononanoate are heated to 60°C to melt, stirred at 40 rpm for 10 min, after stirring evenly, the composition and VE are added, stirred at 60 rpm for 15 min, then stop heating, pour it into the mold, after cooling to get lip balm.

[0051] Comparative Example 6 Take the composition prepared in Comparative Example 3 7g, sunflower wax 10g, candelilla wax 8g, natural beeswax 12g, cocoa butter 15g, shea butter 10g, squalane 8g, isononyl isononanoate 12g, VE 1g.

[0052] The composition is mixed evenly; the sunflower wax, candelilla wax, natural beeswax, cocoa butter, shea butter, squalane and isononyl isononanoate are heated to 60°C to melt, stirred at 40 rpm for 10 min, after stirring evenly, the composition and VE are added, stirred at 60 rpm for 15 min, then stop heating, pour it into the mold, after cooling to get lip balm.

[0053] Test Example 1 Human dermal fibroblasts (HDF) were inoculated in DMEM medium containing 10% fetal bovine serum and cultured in a 37°C, 5% CO2 incubator. After the cells grew to the logarithmic growth phase, the subsequent experiments were carried out.

[0054] A group of cells was reserved as a blank control and was not treated additionally. The remaining cells were cultured to the logarithmic growth phase, and then treated with an inflammation inducer LPS to induce an inflammatory response. The HDF cells successfully induced inflammation were divided into four experimental groups, a model control group and a positive control group, and the anti-cheilitis composition or the control reagent was added according to the following description, respectively, and cultured for 24 hours.

[0055] Group 1: The composition prepared in Example 1 was added to the cells to a concentration of 1 mg / mL; Group 2: The composition prepared in Comparative Example 1 was added to the cells to a concentration of 1 mg / mL; Group 3: The composition prepared in Comparative Example 2 was added to the cells to a concentration of 1 mg / mL; Group 4: The composition prepared in Comparative Example 3 was added to the cells to a concentration of 1 mg / mL; Model control group: An equal volume of normal saline was added to the cells; Positive control group: 0.5 μM of dexamethasone was added to the cells.

[0056] After the end of the culture, the cell supernatant was collected, the release level of inflammatory factors was detected using an ELISA kit, and the expression level of inflammatory-related proteins in the cells was detected using Western blot or immunofluorescence, and the inhibition rate was calculated, and the results are shown in Table 1.

[0057] Inhibition rate = (1 - test group inflammatory factor level / model control group inflammatory factor level) x 100% Table 1 Anti-inflammatory effect of HDF cells

[0058] As can be seen from Table 1, compared with the model control group, the positive control group and the experimental group can reduce the expression level of inflammatory factors to different extents, and the inhibition rate of the first group on inflammatory factors is higher than that of the second to fourth groups, indicating that when the composition provided by the application selects osmanthus extract, radix lithospermi extract, farnesol, phytosphingosine and VB as active ingredients, it has stronger anti-inflammatory activity; compared with Comparative Example 1, the use of phytosphingosine is more conducive to improving the anti-inflammatory activity. Compared with the scheme of not using osmanthus extract or not using radix lithospermi extract, the effect is better when the two are used together, indicating that osmanthus extract and radix lithospermi extract have a synergistic effect when acting on the affected part of cheilitis.

[0059] The cell viability was detected using a CCK-8 kit to evaluate the toxicity of the composition to the cells, and the results are shown in Table 2.

[0060] Cell viability = experimental group cell OD value / blank control group cell OD value x 100% Table 2 Cell toxicity results

[0061] As can be seen from Table 2, the cell viability of the model control group is 80%, indicating that the inflammation induction has a certain damage to the cells, but the cells still maintain a certain viability; the cell viability of the experimental group is >80%, indicating that the composition provided by the application has no obvious toxicity to the cells.

[0062] Test Example 2 Moisturizing test The lipsticks prepared in Embodiment 5 to Embodiment 7 of the present application are taken as samples respectively, and a certain brand of commercially available lipstick is selected as a control.

[0063] Twenty-five volunteers are recruited, and one day before the experiment, the volunteers are asked not to use any lip care products, and then the volunteers are randomly divided into 5 groups.

[0064] The volunteers are asked to wash the lips and gently wipe them with a paper towel. The initial moisture content of the lips of each volunteer is measured by using a skin moisture tester before the experiment, and the data are recorded.

[0065] Group 1: Each volunteer evenly applies the lipstick prepared in Embodiment 5 to the lips, and the application amount of each volunteer is as consistent as possible; Group 2: Each volunteer evenly applies the lipstick prepared in Embodiment 6 to the lips, and the application amount of each volunteer is as consistent as possible; Group 3: Each volunteer evenly applies the lipstick prepared in Embodiment 7 to the lips, and the application amount of each volunteer is as consistent as possible; Group 4: Each volunteer evenly applies a certain brand of commercially available lipstick to the lips, and the application amount of each volunteer is as consistent as possible; Group 5: The volunteers do not apply lipstick.

[0066] At time nodes of 0.5 hours, 1 hour, 2 hours, 4 hours, 8 hours and the like after the application of the lipstick, the moisture content of the lips of each volunteer is measured by using a skin moisture tester respectively, and the data are recorded, and the relative moisture content is calculated.

[0067] Relative moisture content = Moisture content of lips after application of lipstick / Initial moisture content × 100% During the measurement, the appearance changes of the lips of the volunteers, such as whether there are cracks, peeling and the like, are observed, and the observation results are recorded, and the results are shown in Table 3.

[0068] Table 3 Moisturizing conditions of lips at different times after application of lipstick

[0069] It can be known from Table 3 that the lipstick provided by the present application has good moisturizing performance.

[0070] Test Example 3 Lip line lightening test Sixty volunteers with deep lip lines and without other lip diseases are randomly recruited, and the age is between 20 to 50 years old, and the male to female ratio is 1:1.

[0071] The volunteers apply (2.0±0.1) mg / cm 2The lipsticks of Example 1 were evenly applied to the lips in an amount of 0.2 g per time, twice a day, without using any other lip products during the test period, and the test period was 12 weeks.

[0072] After a certain time of application, the lips of the subjects were observed from different angles under natural light by a professional dermatologist or trained evaluator, and visual assessment of the lip lines was performed, and the average roughness and average depth of wrinkles of the lips of the volunteers were measured, and the lip condition of the volunteers was scored and graded, and the results are shown in Table 4. The scoring criteria are as follows: 1 point: The lip lines are slight and only visible at a specific angle, and almost no impact on the appearance.

[0073] 2 points: The lip lines are slight, and the surface of the lips has fine lines, but not obvious, and does not affect the overall appearance.

[0074] 3 points: The lip lines are obvious, and the surface of the lips has more obvious lines, but no deep grooves are formed.

[0075] 4 points: The lip lines are deeper, and the surface of the lips has obvious grooves, affecting the appearance.

[0076] 5 points: The lip lines are very deep, and the surface of the lips has obvious grooves, and may be accompanied by dryness or desquamation.

[0077] Table 4 Lip line lightening effect

[0078] As can be seen from Table 4, after long-term use of the lipsticks provided by the present application, the volunteers can fade the lip lines to varying degrees, and after 12 weeks of use, the number of people with lip lines reaching 5 points is 0, indicating that the lipsticks provided by the present application have good lip line lightening effect.

[0079] Before and after the use of the lipsticks, the average depth of the lip wrinkles was measured using a skin wrinkle tester (ASA-03RXD), and the average roughness of the lips was measured using a skin surface morphology analysis system (MicroSkinII), and the results are shown in Table 5.

[0080] Table 5 Lip roughness level

[0081] As can be seen from Table 5, long-term use of the lipsticks provided by the present application can effectively reduce the average depth of the lip lines and the average roughness of the lip lines.

[0082] Although the above embodiments have made a detailed description of the present application, it is only a part of the embodiments of the present application, not all the embodiments, and other embodiments can be obtained by the present embodiment without creativity, which are within the protection scope of the present application.

Claims

1. A composition for preventing and treating cheilitis, characterized in that: The composition comprises the following components in parts by mass: 1-5 parts of osmanthus fragrans extract, 1-5 parts of lithospermum officinale extract, 1-5 parts of bisabolol, 1-3 parts of phytosphingosine and 0.1-1 part of VB.

2. The composition according to claim 1, characterized in that The osmanthus extract is an ethyl acetate extract or an ethanol extract of osmanthus; the lithospermum extract is an ethyl acetate extract or an ethanol extract of lithospermum.

3. The composition according to claim 2, characterized in that The preparation method of the osmanthus flower alcohol extract comprises the following steps: mixing fresh osmanthus flowers with a 60% to 75% ethanol aqueous solution at a material-liquid ratio of 1 g:15 to 25 mL, performing ultrasonic-assisted extraction at 45° C. to 60° C. with a power of 200 to 300 W for 25 to 45 minutes, and then removing excess solvent by vacuum concentration to obtain the osmanthus flower alcohol extract; The preparation method of the ethyl acetate extract of osmanthus comprises the following steps: mixing fresh osmanthus with ethyl acetate at a material-liquid ratio of 1 g:10-15 mL, performing ultrasonic-assisted extraction at 45° C.-50° C. with a power of 200-500 W for 30-45 minutes, and then removing excess solvent by reduced pressure concentration to obtain the ethyl acetate extract of osmanthus.

4. The composition according to claim 2, characterized in that The preparation method of the lithospermum ethanol extract comprises the following steps: grinding dried lithospermum erythrorhizon, mixing with 60% to 75% ethanol aqueous solution at a material-liquid ratio of 1 g:10 to 15 mL, performing ultrasonic-assisted extraction at 45° C. to 55° C. with a power of 200 to 300 W for 25 to 45 minutes, and then removing excess solvent by concentrating under reduced pressure to obtain the lithospermum ethanol extract; The preparation method of the lithospermum ethyl acetate extract comprises the following steps: crushing dried lithospermum erythrorhizon, mixing with ethyl acetate at a material-liquid ratio of 1 g:10-15 mL, performing ultrasonic-assisted extraction at 45° C.-50° C. with a power of 300-600 W for 30-60 min, and then removing excess solvent by reduced pressure concentration to obtain the lithospermum ethyl acetate extract.

5. Use of the composition according to claim 1 in preparing products for preventing and treating cheilitis and lightening lip lines.

6. An osmanthus lipstick for preventing and treating cheilitis and lightening lip lines, characterized in that: The lipstick comprises the following ingredients, in parts by mass: 5-10 parts of the composition according to claim 1, 5-15 parts of sunflower wax, 5-12 parts of candelilla wax, 8-15 parts of natural beeswax, 10-20 parts of cocoa butter, 5-15 parts of shea butter, 5-10 parts of squalane, 5-15 parts of isononyl isononanoate, and 0.2-2 parts of VE.

7. The method for preparing the lipstick according to claim 6, characterized in that: The method comprises the following steps: The composition according to claim 1 is mixed evenly; sunflower wax, candelilla wax, natural beeswax, cocoa butter, shea butter, squalane and isononyl isononanoate are heated until melted, stirred evenly, the composition and VE are added, and after uniform dispersion, heating is stopped, the mixture is poured into a mold, and cooled to obtain a lipstick.

8. The method according to claim 7, characterized in that The heating temperature is 60°C to 70°C.

9. The method according to claim 7, characterized in that The uniform dispersion condition is stirring at 40-80 rpm for 15-30 min.

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