Preparation method of Chinese herbaceous peony and liquorice root soup granules

Abstract

The invention provides a preparation method of paeonia lactiflora and liquorice decoction granules, which specifically comprises the following steps: performing water extraction on each medicine of a paeonia lactiflora and liquorice decoction prescription to obtain a paeonia lactiflora and liquorice decoction extracting solution, performing butterfly centrifugation to obtain paeonia lactiflora and liquorice decoction centrifugate, performing membrane separation to obtain paeonia lactiflora and liquorice decoction permeate, and further performing concentration, drying and granulation to obtain the paeonia lactiflora and liquorice decoction granules. According to the invention, the turbidity of the solution is obviously reduced through technologies such as membrane filtration, the prepared particles have good solubility, and the dissolved liquid medicine is clear; invalid solid substances are removed, and the daily dose is remarkably reduced.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicines, and in particular to a preparation method of Shaoyao Gancao Tang granules. Background Art

[0002] The prescription of Peony and Licorice Decoction comes from Treatise on Febrile Diseases by Zhang Zhongjing of the Han Dynasty. It has the effects of nourishing yin and blood, relieving pain, and is used to treat spasms and pains caused by yin and blood deficiency and lack of nourishment to tendons and veins. Symptoms include cramps in the legs and feet, and abdominal pain. It has been included in the Catalogue of Ancient Classic Prescriptions (First Batch) and is an important legacy in the treasure house of traditional Chinese medicine.

[0003] At present, classic prescriptions are mainly developed and produced in accordance with the requirements of the "Technical Guidelines for Pharmaceutical Research of Traditional Chinese Medicine Compound Preparations Managed by the Catalog of Ancient Classic Prescriptions (Trial)". Granules are generally made using extraction, concentration, spray drying, dry granulation and other process technologies. However, granules made by this type of preparation process have obvious shortcomings: the granules are not easy to dissolve, and the medicine liquid becomes turbid after dissolution, resulting in a poor experience for patients when taking the medicine; in addition, the daily dosage is generally large. For example, the daily dosage of the marketed Peony and Licorice Granules reaches 18g (equivalent to 55.20g of decoction pieces), which increases the medication burden of patients and affects the convenience and compliance of medication.

[0004] The present invention provides a preparation method, which first uses butterfly centrifugation to achieve preliminary separation of solid and liquid phases to remove most of the larger particle precipitates and insoluble impurities, and then uses membrane separation technology to deeply remove fine particles, colloids, suspended impurities and some large molecular ineffective substances that remain in the medicinal solution after the primary centrifugation, significantly reducing the turbidity of the solution and effectively reducing the solid content. The granules finally prepared are more soluble and significantly reduce the daily dosage for patients. Summary of the Invention

[0005] Based on this, the object of the present invention is to provide a method for preparing Shaoyao Gancao Tang granules to at least solve the above-mentioned deficiencies in the prior art.

[0006] The present invention provides the following technical solution, a method for preparing Shaoyao Gancao Tang granules, the method comprising:

[0007] Prescription composition: white peony root, stir-fried licorice root;

[0008] 1) Extraction and centrifugation: Each medicinal ingredient in the prescription is immersed in an extraction solvent and decocted, and then subjected to shaking, ultrasonication and / or multiple reflux extractions to obtain an extract; the extract is centrifuged to obtain a centrifuge;

[0009] 2) Clarification and filtration: The centrifuge liquid is clarified and filtered using membrane separation technology to remove insoluble particles and obtain the permeate;

[0010] 3) Drying and granulation: The permeate is concentrated to obtain a concentrate, which is dried under reduced pressure or spray-dried to obtain a dry paste powder, and an appropriate amount of excipients is added to the dry paste powder, mixed, and then dry granulated to obtain Shaoyao Gancao Decoction granules;

[0011] Furthermore, the prescription composition includes the following parts by weight: 1-4 parts of white peony root and 1-4 parts of stir-fried licorice.

[0012] Further, take each medicinal ingredient in the prescription, add 5 to 15 times the weight of water of all the medicinal ingredients, soak for 30 to 90 minutes, boil at 90° C. to 100° C., extract 1 to 4 times, each extraction time is 60 to 120 minutes, and obtain an extract.

[0013] Furthermore, the centrifugal method is butterfly centrifugation, the feed flow rate is 1000-2150 L / h, and the rotation speed is rpm.

[0014] Furthermore, the membrane separation technology comprises one or more organic or inorganic membranes, and is selected from tubular, hollow fiber, spiral wound, flat sheet, or ceramic membranes. The pore size of the tubular, hollow fiber, or spiral wound membranes is 5 kD to 1000 kD, while the pore size of the flat sheet or ceramic membranes is 50 to 800 nm. The membrane flux is 0.2 L / min to 8.0 L / min, and the membrane inlet pressure is 0.2 MPa to 2.0 MPa.

[0015] Furthermore, the concentration method is one or more of normal pressure evaporation, reduced pressure evaporation, thin film evaporation, and multi-effect evaporation, and the drying is one or more of spray drying, reduced pressure drying, freeze drying, and belt drying.

[0016] Furthermore, the auxiliary material is at least one of dextrin, maltodextrin, lactose, magnesium stearate and mannitol.

[0017] Furthermore, the process parameters of the granulation are as follows: feeding speed 10-50 rpm, pressing roller speed 5-25 rpm, pressing roller cooling temperature 5-15° C., granulation speed 30-110 rpm, granulation aperture 1.8 mm, and vacuum feeding. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 Flow chart of the preparation method of Shaoyao Gancao Granules in Example 1;

[0019] Figure 2 The liquid chromatograms of samples at each stage of the entire preparation process in Example 1 are shown;

[0020] Figure 3 This is the TLC identification spectrum of Shaoyao Gancao Granules in Examples 1 to 3;

[0021] Figure 4 This is a comparison chart of the content determination of Shaoyao Gancao Granules in Examples 1 to 3;

[0022] The following specific embodiments will further illustrate the present invention in conjunction with the above-mentioned drawings. DETAILED DESCRIPTION

[0023] To facilitate understanding of the present invention, the present invention will be described more fully below with reference to the accompanying drawings. The drawings illustrate several embodiments of the present invention. However, the present invention may be implemented in many different forms and is not limited to the embodiments described herein. Rather, these embodiments are provided to provide a more thorough and comprehensive understanding of the present invention.

[0024] It should be noted that when an element is referred to as being "fixed to" another element, it may be directly on the other element or there may be an intermediate element. When an element is referred to as being "connected to" another element, it may be directly connected to the other element or there may be an intermediate element. The terms "vertical," "horizontal," "left," "right," and similar expressions used herein are for illustrative purposes only.

[0025] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by those skilled in the art to which this invention pertains. The terms used in this specification of the present invention are for the purpose of describing specific embodiments only and are not intended to limit the present invention. The term "and / or" as used herein includes any and all combinations of one or more of the associated listed items.

[0026] Example 1

[0027] The first embodiment of the present invention provides a method for preparing Shaoyao Gancao Tang granules

[0028] Step 1: Weigh 5.52 kg of white peony root and 5.52 kg of stir-fried licorice, put them into a 300 L extraction tank, add 110 L of water, soak for 30 minutes, heat with steam to 98-100 ° C, extract for 90 minutes, filter through 200 mesh filter cloth, and collect the filtrate; add 88 L of water to the solid residue, heat with steam to 98-100 ° C, extract for 60 minutes, filter through 200 mesh filter cloth, collect the filtrate, combine the two filtrates to obtain 172 L of extract.

[0029] Step 2: The extract was separated by a butterfly centrifuge (model: RPDB205VC-01), and the centrifugal pipeline was circulated for 3 to 5 minutes. After the feed flow rate stabilized, the feed liquid was collected to obtain 164L of centrifuge liquid.

[0030] Step 3: Connect the ceramic membrane with a pore size of 500nm to a 50L / h ceramic membrane treatment device (model: M21103). Clarify and filter the centrifuge liquid under the conditions of a membrane temperature of 25°C and a membrane inlet pressure of ≤0.4Mpa. Collect the membrane permeate, take 160L of water, add 20L every 5 minutes to wash the filter membrane, collect the membrane permeate, and combine the membrane permeate and membrane permeate to obtain 304L of permeate.

[0031] Step 4: The permeate was concentrated under reduced pressure at 60°C using a single-effect concentrator (model: WZY-150) to obtain a concentrate with a relative density of 1.00-1.10 (60°C). The concentrate was passed through a 300-mesh sieve to obtain a clear paste with a mass of 13.2 kg.

[0032] Step 5: The concentrate was spray-dried using a centrifugal spray dryer (model: MDR-5) at an air inlet temperature of 170°C, a tower pressure of -60Pa, an atomizer frequency of 60HZ, an air outlet temperature of 90°C, a peristaltic pump speed of 27rpm, and a liquid temperature of 60°C to obtain 1.53 kg of dry paste powder with a moisture content of 4.2%.

[0033] Step 6: Take the dry paste powder and add the auxiliary material maltodextrin. The auxiliary material addition amount = feeding amount × preparation amount / prescription amount - dry paste powder weight. The preparation amount is to prepare 8g of Peony Glycyrrhiza Granules according to the prescription amount (55.20). Maltodextrin addition amount = 11.04 × 8 / 55.2-1.53 ​​= 0.07kg. Mix the auxiliary material and dry paste powder. Use a dry granulator with a feed speed of 20rpm, a roller speed of 10rpm, a roller cooling temperature of 10°C, a granulation speed of 30pm, a granulation aperture of 1.8mm, and vacuum loading to prepare granules. The granule yield is 92.8%.

[0034] The whole process monitoring chromatogram is shown in Figure 2 Shown, from top to bottom, are the extract chromatogram (A), centrifuged liquid chromatogram (B), permeate chromatogram (C), concentrated liquid chromatogram (D), dry paste powder chromatogram (E), and granule chromatogram (F). The Shaoyao Gancao Tang granules preparation process exhibits stable quantitative transfer throughout, with all 10 characteristic components retained intact.

[0035] Example 2

[0036] A second embodiment of the present invention provides a method for preparing Shaoyao Gancao Tang granules.

[0037] Step 1: Weigh 27.6 kg of white peony root and 27.6 kg of fried licorice, put them into a 1500 L extraction tank, add 552 L of water, soak for 30 minutes, heat with steam to 98-100 ° C, extract for 90 minutes, filter through 200 mesh filter cloth, and collect the filtrate; add 883 L of water to the solid residue, heat with steam to 98-100 ° C, extract for 60 minutes, filter through 200 mesh filter cloth, collect the filtrate, combine the two filtrates to obtain 800 L of extract.

[0038] Step 2: The extract was separated by a butterfly centrifuge (model: S21102), and the centrifugal pipeline circulated for 3 to 5 minutes. After the feed flow rate stabilized, the feed liquid was collected to obtain 797L of centrifuge liquid.

[0039] Step 3: Connect the ceramic membrane with a pore size of 500nm to a 500L / h ceramic membrane treatment device (model: M21102). Clarify and filter the centrifuge liquid under the conditions of a membrane temperature of 25°C and a membrane inlet pressure of ≤2.5Mpa. Collect the membrane permeate, take 800L of water, add 40L every 6 minutes to wash the filter membrane, collect the membrane permeate filtrate, combine the membrane permeate and the membrane permeate filtrate to obtain 1564L of permeate.

[0040] Step 4: The permeate was concentrated under reduced pressure at 60°C using a single-effect concentrator (model: WZY-1000) to obtain a concentrate with a relative density of 1.00-1.10 (60°C). The concentrate was passed through a 300-mesh sieve to obtain a clear paste with a mass of 74.3 kg.

[0041] Step 5: The concentrate was spray-dried using a centrifugal spray dryer (model: MDR-20) at an air inlet temperature of 170°C, a tower pressure of -60Pa, an atomizer frequency of 60HZ, an air outlet temperature of 90°C, a peristaltic pump speed of 27rpm, and a liquid temperature of 60°C to obtain 7.10 kg of dry paste powder with a moisture content of 3.7%.

[0042] Step 6: Take the dry paste powder and add the auxiliary material maltodextrin. The auxiliary material addition amount = feeding amount × preparation amount / prescription amount - dry paste powder weight. The preparation amount is to prepare 8g of Peony and Licorice Granules according to the prescription amount (55.2g). Maltodextrin addition amount = 55.2 × 8 / 55.2-7.10 = 0.9kg. Mix the auxiliary material and dry paste powder. Use a dry granulator with a feed speed of 20rpm, a roller speed of 10rpm, a roller cooling temperature of 10°C, a granulation speed of 30pm, a granulation aperture of 1.8mm, and vacuum loading to prepare granules. The granule yield is 90.1%.

[0043] Example 3

[0044] A third embodiment of the present invention provides a method for preparing Shaoyao Gancao Tang granules.

[0045] Step 1: Weigh 27.6 kg of white peony root and 27.6 kg of fried licorice, put them into a 1500 L extraction tank, add 552 L of water, soak for 30 minutes, heat with steam to 98-100 ° C, extract for 90 minutes, filter through 200 mesh filter cloth, and collect the filtrate; add 883 L of water to the solid residue, heat with steam to 98-100 ° C, extract for 60 minutes, filter through 200 mesh filter cloth, collect the filtrate, combine the two filtrates to obtain 860 L of extract.

[0046] Step 2: The extract was separated by a butterfly centrifuge (model: S21102), and the centrifugal pipeline was circulated for 3 to 5 minutes. After the feed flow rate stabilized, the feed liquid was collected to obtain 824L of centrifuge liquid.

[0047] Step 3: Connect a 100KD PVDF wound membrane to a 500L / h ultrafiltration device (model: NF-7200). Clarify and filter the centrifuge liquid at a membrane temperature of 25°C and a membrane inlet pressure of ≤2.5Mpa. Collect the membrane permeate, take 800L of water, add 40L every 6 minutes to wash the membrane, collect the membrane permeate, and combine the membrane permeate and membrane permeate to obtain 1494L of permeate.

[0048] Step 4: The permeate was concentrated under reduced pressure at 60°C using a single-effect concentrator (model: WZY-1000) to obtain a concentrate with a relative density of 1.00-1.10 (60°C). The concentrate was passed through a 300-mesh sieve to obtain a clear paste with a mass of 78.8 kg.

[0049] Step 5: The concentrate was spray-dried using a centrifugal spray dryer (model: MDR-20) at an air inlet temperature of 170°C, a tower pressure of -60Pa, an atomizer frequency of 60HZ, an air outlet temperature of 90°C, a peristaltic pump speed of 27rpm, and a liquid temperature of 60°C to obtain 7.25 kg of dry paste powder with a moisture content of 2.5%.

[0050] Step 6: Take the dry paste powder and add the auxiliary material maltodextrin. The auxiliary material addition amount = feeding amount × preparation amount / prescription amount - dry paste powder weight. The preparation amount is to prepare 8g of Peony and Licorice Granules according to the prescription amount (55.2g). Maltodextrin addition amount = 55.2 × 16 / 110.4-7.25 = 0.75kg. Mix the auxiliary material and dry paste powder. Use a dry granulator with a feed speed of 20rpm, a roller speed of 10rpm, a roller cooling temperature of 10°C, a granulation speed of 30pm, a granulation aperture of 1.8mm, and vacuum loading to prepare granules. The granule yield is 89.7%.

[0051] According to the above-mentioned embodiments 1 to 3, after the Shaoyao Gancao Tang granules are prepared, it is necessary to perform a quality test on the prepared Shaoyao Gancao Tang granules. The specific method is as follows:

[0052] [Particle Size] Unless otherwise specified, the particle size and particle size distribution shall be determined according to the particle size and particle size distribution determination method (the second method of double screening method in the fourth general rule of the Chinese Pharmacopoeia 2020 edition, Part IV, 0982). The sum of the particles that cannot pass through the No. 1 sieve and those that can pass through the No. 5 sieve shall not exceed 15%.

[0053] [Moisture] Chinese herbal granules shall be determined according to the moisture determination method (General Chapter 0832 of Part IV of the 2020 edition of the Chinese Pharmacopoeia). Unless otherwise specified, the moisture content shall not exceed 8.0%.

[0054] [Solubility] Take 10g of the test sample (take 1 bag from the single-dose package of traditional Chinese medicine), add 200ml of hot water, stir for 5 minutes, and observe immediately. The soluble particles should be completely dissolved or slightly turbid.

[0055]

Thin layer identification

[0056] Thin layer identification 1

[0057] Preparation of reference solution: Take the paeoniflorin reference substance and add ethanol to make a solution containing 1 mg per 1 ml as the reference solution;

[0058] Preparation of test solution: Take 0.15g of the product granules, add 10ml of ethanol, shake for 5 minutes, filter, evaporate the filtrate to dryness, and dissolve the residue in 1ml of ethanol to prepare the test solution;

[0059] The thin layer chromatography identification test conditions are:

[0060] Thin layer plate: Silicone G thin layer plate

[0061] Spotting: 10 μl of reference solution and 10 μl of test solution, spotting in strip form;

[0062] Developing solvent: chloroform-ethyl acetate-methanol-formic acid (volume ratio 40:5:10:0.2);

[0063] Color developer: 5% vanillin sulfuric acid solution;

[0064] Inspection: Heat at 105℃ until the spots are clearly colored, and inspect under sunlight.

[0065] Test results such as Figure 3 As shown in A, Figure 3 In the chromatogram in A, A1-A4 respectively represent: A1 corresponds to the paeoniflorin reference substance, A2 corresponds to the granules of Example 1, A3 corresponds to the granules of Example 2, and A4 corresponds to the granules of Example 3. Result analysis: In the chromatogram of the test sample, the same blue-purple spot appears at the corresponding position in the chromatogram of the reference substance.

[0066] Thin layer identification 2

[0067] Preparation of reference solution: Take the monoammonium glycyrrhizinate reference substance and add methanol to make a solution containing 2 mg per 1 mL as the reference solution;

[0068] Preparation of test solution: Take 0.3 g of the powder of this product, add 40 mL of ether, heat and reflux for 1 hour, filter, discard the ether solution, add 30 mL of methanol to the residue, heat and reflux for 1 hour, filter, evaporate the filtrate to dryness, dissolve the residue in 40 mL of water, extract with n-butanol 3 times, 20 mL each time, combine the n-butanol solutions, wash with water 3 times, discard the water solution, evaporate the n-butanol solution to dryness, dissolve the residue in 5 mL of methanol to prepare the test solution;

[0069] The thin layer chromatography identification test conditions are:

[0070] Thin layer plate: Silica gel G thin layer plate prepared with 1% sodium hydroxide solution

[0071] Spotting: 2 μl of reference solution and 2 μl of test solution, spotting in strip form;

[0072] Developing solvent: ethyl acetate-formic acid-glacial acetic acid-water (volume ratio 15:1:1:2);

[0073] Color developer: 10% sulfuric acid ethanol solution;

[0074] Inspection: Heat at 105°C until the spots are clearly colored, and inspect under ultraviolet light (365nm).

[0075] Test results such as Figure 3 As shown in B, Figure 3 In the chromatogram of B, B1-B4 respectively represent: B1 corresponds to the glycyrrhizic acid monoammonium salt reference substance, B2 corresponds to the granules of Example 1, B3 corresponds to the granules of Example 2, and B4 corresponds to the granules of Example 3. Result analysis: In the chromatogram of the test sample, the same orange-yellow fluorescent spot appears at the corresponding position in the chromatogram of the reference substance.

[0076] [Fingerprint] Determined according to high performance liquid chromatography (General Chapter 0512 of the 2020 edition of the Chinese Pharmacopoeia).

[0077] Chromatographic conditions and system suitability testing were performed using octadecylsilane bonded silica gel as the packing (column length, 100 mm, inner diameter, 2.1 mm, particle size, 1.7 μm); acetonitrile as mobile phase A, 0.1% phosphoric acid solution as mobile phase B, with gradient elution as specified in the table below; the flow rate was 0.4 mL / min; the column temperature was 30°C. The detection wavelength was 230 nm. The number of theoretical plates, calculated based on the paeoniflorin peak, must be no less than 5000.

[0078]

[0079] Preparation of reference solution: Take appropriate amounts of paeoniflorin, liquiritin reference substance, and ammonium glycyrrhizate reference substance, accurately weigh them, and add methanol to make solutions containing 60 μg of paeoniflorin and glycyrrhizin, 20 μg of liquiritin, and 200 μg of ammonium glycyrrhizate per 1 mL.

[0080] Preparation of test solution: Take an appropriate amount of the product, grind it into powder, take about 1.0 g, accurately weigh it, place it in a stoppered conical flask, accurately add 50 mL of 70% methanol, stopper it tightly, weigh it, and treat it ultrasonically (power 400 W, frequency 40 kHz) for 30 minutes. Let it cool, weigh it again, make up the lost weight with 70% methanol, shake it well, filter it, and take the filtrate to obtain the product.

[0081] Determination method: Accurately aspirate 1 μL of reference solution and test solution respectively, inject into liquid chromatograph, and determine.

[0082] The test sample chromatogram should show 12 characteristic peaks, of which 3 peaks should correspond to the retention times of the corresponding reference peaks. According to the similarity evaluation system for chromatographic fingerprints of traditional Chinese medicines, the similarity between the test sample fingerprint and the reference fingerprint should not be less than 0.90.

[0083] [Content Determination] Determined by high performance liquid chromatography (General Chapter 0512 of the 2020 edition of the Chinese Pharmacopoeia).

[0084] The chromatographic conditions and system suitability test are the same as those in the [Content Determination] item.

[0085] The preparation of reference solution is the same as that in [Content Determination].

[0086] The preparation of the test solution is the same as that in [Content Determination].

[0087] The determination method is the same as that of [Content Determination].

[0088] Take the reference solution and the test solution under the above fingerprint, and determine the content according to the fingerprint detection conditions. The chromatogram is as follows Figure 4 As shown, from top to bottom are the chromatogram of Shaoyao Gancao Tang granules of Example 1 (A), the chromatogram of Shaoyao Gancao Tang granules of Example 2 (B), and the chromatogram of Shaoyao Gancao Tang granules of Example 3 (C).

[0089] The test results of Examples 1 to 3 are shown in the following table: the Shaoyao Gancao Tang granules prepared by the present invention have uniform quality, small batch differences, and good quality consistency.

[0090]

[0091] The present invention provides a method for preparing Shaoyao Gancao Tang granules, specifically, the various medicinal ingredients of Shaoyao Gancao Tang are extracted with water to obtain Shaoyao Gancao Tang extract, butterfly centrifugation is used to obtain Shaoyao Gancao Tang centrifuge, membrane separation is used to obtain Shaoyao Gancao Tang permeate, and then Shaoyao Gancao Tang granules are obtained by concentration, drying, and granulation. The Shaoyao Gancao Tang granules proposed by the present invention have the following advantages:

[0092] 1) Compared with the granules prepared by the traditional classic prescription preparation process, which are not easy to dissolve and the liquid after dissolution is turbid, the granules prepared by the present invention have good solubility and the liquid after dissolution is clear;

[0093] 2) The daily dosage of Shaoyao Gancao Granules from manufacturer 1 is 10g (equivalent to 55.20g of the decoction pieces), and the daily dosage of Shaoyao Gancao Decoction Granules from manufacturer 2 is 18g (equivalent to 55.20g of the decoction pieces). The daily dosage of the granules prepared by the present invention is 4g (equivalent to 55.20g of the decoction pieces), which is a low daily dosage;

[0094] 3) The preparation method of the present invention uses a physical method to remove ineffective substances, does not require chemical reactions, has low energy consumption, occupies a small area of ​​equipment, is easy to automate and control, can be used for large-scale production, and has good industrial prospects.

[0095] Throughout this specification, reference to terms such as "one embodiment," "some embodiments," "examples," "specific examples," or "some examples" means that a specific feature, structure, material, or characteristic described in conjunction with that embodiment or example is included in at least one embodiment or example of the present invention. In this specification, schematic representations of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.

[0096] The above-described embodiments merely illustrate several implementations of the present invention, and while their descriptions are relatively specific and detailed, they should not be construed as limiting the scope of the present invention. It should be noted that a person skilled in the art would be able to make numerous variations and improvements without departing from the spirit of the present invention, all of which fall within the scope of protection of the present invention. Therefore, the scope of protection of the present invention shall be determined by the appended claims.

Claims

1. A method for preparing Shaoyao Gancao Tang granules, characterized in that: The preparation method comprises: Shaoyao Gancao Decoction prescription composition: white peony root, stir-fried licorice root; 1) Extraction and centrifugation: Each medicinal ingredient in the prescription is immersed in an extraction solvent and decocted, and then subjected to shaking, ultrasonication and / or reflux extraction in sequence to obtain an extract; the extract is centrifuged to obtain a centrifuge; 2) Clarification and filtration: The centrifuge liquid is clarified and filtered using membrane separation technology to remove insoluble particles and obtain the permeate; 3) Drying and granulation: The permeate is concentrated to obtain a concentrated solution, and the concentrated solution is dried under reduced pressure or spray-dried to obtain a dry paste powder. An appropriate amount of auxiliary materials is added to the dry paste powder, mixed, and then granulated by dry method to obtain Shaoyao Gancao Decoction granules.

2. The method for preparing Shaoyao Gancao Tang granules according to claim 1, characterized in that: The prescription composition includes the following parts by weight: 1-4 parts of white peony root and 1-4 parts of stir-fried liquorice.

3. The method for preparing the Shaoyao Gancao Tang granules according to claim 1, characterized in that: The extraction solvent is water, the weight of the extraction solvent is 5 to 15 times the weight of all the medicinal ingredients, the soaking time is 30 to 90 minutes, the decoction temperature is 90° C. to 100° C., the number of extractions is 1 to 4 times, and the extraction time is 60 to 120 minutes.

4. The method for preparing the Shaoyao Gancao Tang granules according to claim 1, characterized in that: The centrifugal method is butterfly centrifugation, the feed flow rate is 1000-2150 L / h, and the rotation speed is rpm.

5. The preparation method of Shaoyao Gancao Tang granules according to claim 1, characterized in that: The types of filter membranes in the membrane separation technology are one or more of organic membranes or inorganic membranes, and the membranes are one or more of tubular membranes, hollow fiber membranes, rolled membranes, flat membranes or ceramic membranes. The pore size of the tubular membranes, hollow fiber membranes and rolled membranes is 5kD to 1000kD; the pore size of the flat membrane or ceramic membrane is 50 to 800nm, the membrane flux of the filter membrane is 0.2L / min to 8.0L / min, and the membrane inlet pressure of the filter membrane is 0.2MPa to 2.0MPa.

6. The method for preparing Shaoyao Gancao Tang granules according to claim 1, characterized in that: The concentration method is one or more of normal pressure evaporation, reduced pressure evaporation, thin film evaporation, and multi-effect evaporation; the drying is one or more of spray drying, reduced pressure drying, freeze drying, and belt drying.

7. The method for preparing Shaoyao Gancao Tang granules according to claim 1, characterized in that: The auxiliary material is at least one of dextrin, maltodextrin, lactose, magnesium stearate and mannitol.

8. The method for preparing Shaoyao Gancao Tang granules according to claim 1, characterized in that: The process parameters of the granulation are as follows: a feeding speed of 10 to 50 rpm, a pressing roller speed of 5 to 25 rpm, a pressing roller cooling temperature of 5 to 15° C., a granulation speed of 30 to 110 rpm, a granulation aperture of 1.8 mm, and vacuum feeding.

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