Right heart failure detection method and device

Abstract

The invention provides a right heart failure detection method and device.The method comprises the steps that a first pumping flow curve is obtained, and the first pumping flow curve is a pumping flow curve within a target period when a ventricular assist device operates at a target rotating speed; determining at least one target parameter according to the first pumping flow curve; and if the at least one target parameter meets the preset condition, determining that the right heart failure exists. The target parameters capable of measuring the state of the right heart are obtained from the pumping flow curve of the ventricular assist device implanted into the left heart in real time, whether the current ventricular assist device causes the right heart failure or not is determined through comparison, and real-time detection of the right heart failure is achieved.

Description

Technical Field

[0001] The present application relates to the field of medical device technology, and in particular to a method and device for detecting right heart failure. Background Art

[0002] A ventricular assist device (VAD) is an effective treatment for heart failure. It is an artificial mechanical device that directs fluid from the venous system or heart directly into the arterial system, partially or completely replacing the work of the ventricles. After a VAD is implanted in a patient with left heart failure, its use increases the amount of blood returning to the right ventricle. Long-term use may lead to right heart failure. Right heart failure poses a serious threat to the patient's life. Therefore, detecting the potential for right heart failure in the early stages of a patient's right heart failure through pump flow analysis is crucial for improving patient survival and quality of life. Summary of the Invention

[0003] The embodiments of the present application provide a right heart failure detection method and device, which can monitor in real time whether a ventricular assist device implanted in the left heart causes right heart failure.

[0004] In a first aspect, an embodiment of the present application provides a method for detecting right heart failure, which is applied to a ventricular assist device, wherein the ventricular assist device is used for the left heart. The method includes:

[0005] acquiring a first pumping flow curve, where the first pumping flow curve is a pumping flow curve within a target cycle when the ventricular assist device operates at a target speed;

[0006] determining at least one target parameter according to the first pumping flow rate curve, wherein the target parameter is used to measure the state of the right heart;

[0007] If the at least one target parameter satisfies the preset conditions, it is confirmed that right heart failure exists.

[0008] In a second aspect, embodiments of the present application provide a control circuit for a ventricular assist device, wherein the ventricular assist device is used for the left side of the heart. The control circuit includes one or more processors, wherein the one or more processors are configured to:

[0009] acquiring a first pumping flow curve, where the first pumping flow curve is a pumping flow curve within a target cycle when the ventricular assist device operates at a target speed;

[0010] determining at least one target parameter according to the first pumping flow rate curve, wherein the target parameter is used to measure the state of the right heart;

[0011] If the at least one target parameter satisfies the preset conditions, it is confirmed that right heart failure exists.

[0012] In a fourth aspect, an embodiment of the present application provides a ventricular assist device for a left heart, comprising:

[0013] a housing;

[0014] an impeller arranged in the housing;

[0015] a motor driving the impeller to rotate in suspension;

[0016] the control circuit connected with the motor, the control circuit being configured to perform some or all of the steps described in the method of the first aspect.

[0017] In a fourth aspect, an embodiment of the present application provides a medical device, comprising a processor, a memory, a communication interface, and one or more programs stored in the memory and configured to be executed by the processor, the program comprising instructions for performing some or all of the steps described in the method of the first aspect.

[0018] In a fifth aspect, an embodiment of the present application provides a computer readable storage medium storing a computer program for electronic data exchange, wherein the computer program causes a computer to perform some or all of the steps described in the method of the first aspect.

[0019] In a sixth aspect, an embodiment of the present application provides a computer program product, wherein the above computer program product includes a non-transitory computer-readable storage medium storing a computer program, and the computer program is operable to cause a computer to perform some or all of the steps described in the method of the first aspect of the present application. The computer program product can be a software installation package.

[0020] The technical solution provided in the present application obtains a first pumping flow curve, which is a pumping flow curve of a target cycle when the ventricular assist device operates at a target rotating speed; determines at least one target parameter according to the first pumping flow curve; and confirms that right heart failure exists if all the at least one target parameter meet preset conditions. The present application obtains a target parameter capable of measuring the state of the right heart from the pumping flow curve of the ventricular assist device implanted in the left heart in real time, and then determines whether the operation of the current ventricular assist device causes right heart failure through comparison, thereby realizing real-time detection of right heart failure. BRIEF DESCRIPTION OF DRAWINGS

[0021] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings needed in the embodiments will be briefly introduced as follows. Obviously, the drawings in the following description are some embodiments of the present application, and other drawings can also be obtained by those skilled in the art without creative labor.

[0022] Figure 1 is a schematic diagram of a ventricular assist system provided in an embodiment of the present application;

[0023] Figure 2 1 is a flow chart of a method for detecting right heart failure provided in an embodiment of the present application;

[0024] Figure 3 Schematic diagram of Fourier transformation of a pumping flow rate curve provided in an embodiment of the present application;

[0025] Figure 4 This is a structural diagram of a medical device provided in an embodiment of the present application. DETAILED DESCRIPTION

[0026] In order to help those skilled in the art better understand the technical solutions of this application, the following is a clear and complete description of the technical solutions in the embodiments of this application in conjunction with the drawings in the embodiments of this application. Obviously, the described embodiments are only some embodiments of this application, not all embodiments. Based on the description of the embodiments of this application, all other embodiments obtained by those skilled in the art without making creative efforts are within the scope of protection of this application.

[0027] The terms "first," "second," and so on in the specification and claims of this application and the accompanying drawings are used to distinguish between different objects, not to describe a specific order. In addition, the terms "including," "having," and any variations thereof are intended to cover non-exclusive inclusions. For example, a process, method, software, product, or apparatus comprising a series of steps or elements is not limited to the listed steps or elements but may also include steps or elements not listed, or may include other steps or elements inherent to the process, method, product, or apparatus.

[0028] References herein to "embodiments" mean that a particular feature, structure, or characteristic described in connection with the embodiments may be included in at least one embodiment of the present application. The appearance of this phrase in various places in the specification does not necessarily refer to the same embodiment, nor does it constitute an independent or alternative embodiment that is mutually exclusive of other embodiments. It is understood, both explicitly and implicitly, by those skilled in the art that the embodiments described herein may be combined with other embodiments.

[0029] The medical devices and pumps involved in this application may be ventricular assist devices, such as implantable ventricular assist devices and invasive ventricular assist devices. A ventricular assist device may include at least one blood pump, which may be a centrifugal pump, an axial flow pump, or a magnetic levitation pump. The embodiments of this application are described using a centrifugal magnetic levitation pump as an example.

[0030] As used herein, "speed" refers to the rotational speed of a motor or electric motor, which is related to the rotational speed of the rotor or impeller of a ventricular assist device and may be defined as revolutions per minute. "Flow," "fluid flow," or "pump flow" refers to the volume of fluid delivered through the ventricular assist device per unit time, which may be measured in liters per minute.

[0031] See also Figure 1 , Figure 1 Schematic diagram of a ventricular assist system proposed in an embodiment of the present application. The ventricular assist system includes a ventricular assist device 100 and a control device 200. The ventricular assist device 100 includes an impeller, a motor that drives the impeller to rotate in suspension, and a control circuit that controls the operation of the motor. The control circuit is connected to the control device 200 via a percutaneous cable, and the power of the control device 200 is transmitted to the control circuit via the percutaneous cable. The control circuit controls the operation of the motor by controlling the current flowing through the motor; and communication between the control circuit and the control device 200 is achieved via the percutaneous cable.

[0032] VAD 100 can be placed in the patient's left heart to pump blood from the left ventricle to the aorta. It can also be placed in the patient's right heart to pump blood from the right ventricle to the pulmonary artery. Control device 200 is in communication with VAD 100 to control the operation of VAD 100. The following description uses the VAD 100 placed in the left heart as an example.

[0033] The ventricular assist device 100 can be attached to the apex of the right ventricle of the heart via a ventricular connection assembly (such as a top ring, a ventricular cuff, or a ventricular cuff). The ventricular connection assembly can be sutured to the apex of the right ventricle of the heart and connected to the ventricular assist device. The other end of the ventricular assist device 100 can be connected to the pulmonary artery via an outlet tube and / or an artificial blood vessel connected to the outlet tube. In this way, the ventricular assist device 100 can effectively divert blood from the weakened right ventricle and propel it to the pulmonary artery, thereby circulating it to the rest of the patient's vascular system and providing ventricular assist function for the patient. Similarly, the ventricular assist device 100 can also be attached to the apex of the left ventricle of the heart via the ventricular connection assembly to provide ventricular assist function for the patient.

[0034] From the flow direction of the user's blood, the fluid systems are arranged in series with each other, the blood flows through the superior vena cava and the inferior vena cava to the right atrium, the blood is pumped from the right atrium to the right ventricle when the right ventricle is diastolic, and the blood is pumped from the right ventricle to the pulmonary artery when the right ventricle is systolic. The pulmonary artery flows to the lung, and the lung system is in direct fluid communication with the left ventricle. After the blood in the lung is oxygenated, it returns to the left atrium through the pulmonary vein. The blood is pumped from the left atrium to the left ventricle when the left ventricle is diastolic, and the blood is pumped from the left ventricle to the aorta when the left ventricle is systolic. The blood in the aorta flows back to the right atrium through the user's blood vessel system. Therefore, the blood forms a fluid circulation in the pulmonary artery, the right ventricle, the left ventricle and the aorta in turn.

[0035] The mutual influence between the left heart and the right heart, the fluid flow in the ventricle is related to the blood volume in the ventricle and the pressure difference, and the change of the fluid flow in one ventricle will cause the corresponding change of the fluid flow in the other ventricle. After the patient implants the ventricular assist device 100 in the left heart due to left heart failure, the ventricular assist device 100 increases the output of the left ventricle, resulting in more blood flow through the pulmonary circulation and back to the right ventricle. The sudden increase in blood flow increases the load of the right ventricle, and this long-term overload can cause right heart failure.

[0036] Based on this, the present application provides a right heart failure detection method, after the ventricular assist device is implanted in the left heart and operates, the flow curve of the ventricular assist device is obtained, the influence of the ventricular assist device on the right heart is reflected through the change of the flow curve, and it is judged whether the right ventricle is in failure.

[0037] In combination with the above description, the present application will be described below from the perspective of method examples.

[0038] Please refer to Figure 2 , Figure 2 A right heart failure detection method flow chart provided by an embodiment of the present application is applied to a ventricular assist device as shown in Figure 1 As shown in Figure 2 The method comprises the following steps.

[0039] S210, obtaining a first pumping flow curve, the first pumping flow curve is a pumping flow curve in a target period when the ventricular assist device operates at a target rotating speed.

[0040] During the operation of the ventricular assist device 100 in the user, the pumping flow rate through the ventricular assist device 100 depends on the resistance that the ventricular assist device 100 needs to overcome to pump blood from the left ventricle to the aorta. The amount of work done by the ventricular assist device 100 can be quantified as the amount of current that needs to be supplied to the motor, i.e. the motor current corresponds to the amount of current delivered to the motor of the ventricular assist device 100 when the ventricular assist device 100 is operating in the user. During different phases of the cardiac cycle of the user's heart, the load on the motor will vary. As the pressure differential in the user's heart changes, the motor current will also change to keep the rotor speed constant. For example, when the flow rate of blood into the aorta increases (as during systole), the current required by the motor will increase. Changes in the motor current can therefore help characterize the performance of the heart. That is, during the operation of the ventricular assist device 100, the ventricular assist device 100 has a current-flow characteristic curve, where the greater the current, the more work the ventricular assist device 100 does, i.e. the greater the pumping flow rate of the ventricular assist device 100.

[0041] The current of the ventricular assist device 100 can be measured by a set of phase current detection circuits or any other suitable means (such as a current sensor). The current-flow characteristic curve can be pre-stored in the control circuit. Before the ventricular assist device 100 is shipped, it can be placed in a test system to test the relationship between the pumping flow rate and the current of the ventricular assist device 100 at different rotation speeds, and then the current-flow characteristic curve is stored in the control circuit. The control circuit can store the detected current in real time.

[0042] After the control device 200 obtains the current curve when the ventricular assist device 100 is operating at the target rotation speed, the control device 200 estimates the flow curve corresponding to the current curve using the pre-stored current-flow characteristic curve to obtain a first pumping flow curve.

[0043] Wherein, the target rotation speed is within the rotation speed range allowed by the ventricular assist device 100, such as 36000 RPM when the rotation speed range is 23000 RPM-46000 RPM. The target period can be set as a multiple of the cardiac cycle of the patient, such as 5 times, 10 times, 30 times, etc. of the cardiac cycle. For example, the first period is 5s, 10s, 15s, 20s, etc.

[0044] S220, determining at least one target parameter according to the first pumping flow curve, the target parameter being used to measure the right heart state.

[0045] The ventricular assist device 100 increases the output of the left ventricle, resulting in an increase in the blood flow through the pulmonary circulation back to the right ventricle, increasing the load of the right ventricle, and long-term can cause right heart failure. Due to the interaction between the left and right heart, when the patient develops right heart failure, the performance of the left ventricle and the ventricular assist device will also be affected.

[0046] For example, the at least one target parameter includes a target heart rate. When the heart contracts normally, an increase in heart rate will increase the cardiac output (cardiac output = heart rate * stroke volume). The pumping flow of the ventricular assist device and the heart rate of the patient can be mutually adjusted in the cardiovascular system, and the heart rate adjusts the pumping flow of the ventricular assist device by affecting the blood flow back to the ventricle, and the sufficient blood flow in the ventricle can also adjust the heart rate through hemodynamic feedback.

[0047] When the patient suffers from heart failure, the stroke volume will decrease, and under the condition that the heart rate remains unchanged, the cardiac output at this time cannot meet the physiological needs of the patient. Therefore, without medical intervention, the body's compensation is to increase the heart rate to increase the cardiac output. Therefore, when the patient implanted with the left ventricular assist device develops right heart failure, the heart rate will increase. Therefore, by obtaining the current heart rate of the patient, whether the patient currently develops right heart failure can be measured.

[0048] Optionally, the determining at least one target parameter according to the first pumping flow curve comprises: performing Fourier transform on the first pumping flow curve to obtain a target flow spectrum; and determining a frequency with the maximum power in the target flow spectrum as the target heart rate.

[0049] The pumping flow curve of the ventricular assist device can be used to evaluate the running state of the ventricular assist device and the hemodynamic characteristics through the energy distribution characteristics obtained by frequency domain decomposition of the blood flow curve through the spectrum analysis technology (Fourier transform). Under normal circumstances, the spectrum of the pumping flow curve of the ventricular assist device has a significant power peak at the frequency corresponding to the heart rate, as shown in Figure 3 After the pumping flow curve of the ventricular assist device is subjected to Fourier transform, a spectrum diagram thereof is obtained.

[0050] The control device 200 can perform Fourier transform on the first pumping flow curve to obtain a target flow spectrum of the current ventricular assist device, and determine a frequency corresponding to the first power maximum (peak) in the target flow spectrum as the target heart rate of the patient. Further, whether the patient develops right heart failure can be judged according to the size of the target heart rate.

[0051] For example, the at least one target parameter can also include a target pumping flow. The target pumping flow is the pumping flow of the ventricular assist device in one cardiac cycle of the patient.

[0052] Right heart failure can make the right ventricle unable to effectively pump blood to the lungs, resulting in obstruction of blood return in the pulmonary circulation. Due to the decline in the right ventricular pumping function, the amount of blood returning from the veins to the left ventricle is reduced, thereby affecting the filling of the left ventricle and, in turn, the pumping effect of the ventricular assist device. Although the ventricular assist device can assist the left ventricle in pumping blood, its efficiency depends on blood return and the filling of the left ventricle. When the pulmonary circulation pressure increases and venous return is obstructed due to right heart failure, the pumping efficiency of the ventricular assist device is also limited, resulting in a reduction in the overall heart pumping volume. Therefore, by obtaining the total pumping flow of the ventricular assist device during the cardiac cycle, it can be used to determine whether the current patient has right heart failure.

[0053] Optionally, determining at least one target parameter based on the first pumping flow curve includes: extracting the first pumping flow curve according to a preset sliding window; calculating the total pumping flow of the first pumping flow curve in each sliding window respectively; and calculating the average value of the total pumping flow to obtain the target pumping flow.

[0054] The first pumping flow curve is a pumping flow curve of the ventricular assist device over multiple cardiac cycles. To calculate the total pumping flow within one cardiac cycle, the control device 200 can set a sliding window, which is the length of one cardiac cycle, so that the first pumping flow curve can be divided into pumping flow curves of the length of each cardiac cycle. The total pumping flow of the pumping flow curve within each sliding window is then calculated separately. To further eliminate randomness and improve the accuracy of the target pumping flow, the control device 200 can calculate the average value of the total pumping flow, that is, the total pumping flow within each cardiac cycle is accumulated and divided by the number of cardiac cycles included in the first pumping flow curve, thereby obtaining the total pumping flow within one cardiac cycle.

[0055] For example, the at least one target parameter may further include a target pulsation index.

[0056] When the VAD speed remains constant, the pumping flow rate is constant. Therefore, the fluctuation in pumping flow rate is highly dependent on heart function. When right heart failure occurs, heart function declines, which in turn reduces the pulsatility index of the VAD pumping flow rate. Therefore, obtaining the pulsatility index of the VAD pumping flow rate can be used to measure current right ventricular failure.

[0057] Wherein, determining at least one target parameter based on the first pumping flow curve includes: obtaining the maximum flow value, the minimum flow value and the average flow value of the first pumping flow curve; and calculating the target pulsation index based on the maximum flow value, the minimum flow value and the average flow value.

[0058] The pulsatility index refers to the relationship between the number of heartbeats per minute and each beat. It is an indicator that reflects cardiac function and can be used to assess cardiac load. When the heart is overloaded, the pulsatility index increases; when the heart is relieved, the pulsatility index decreases. Therefore, the pulsatility index can be used to monitor changes in cardiac output. The greater the pulsating blood flow, the greater the pulsating component and the greater the pulsation index. The pulsation index can be calculated based on the first flow curve. The maximum flow rate, the minimum flow rate, and the average flow rate of the first pumping flow curve are obtained from the first flow curve, and the target pulsation index is calculated based on the ratio of ((maximum flow rate - minimum flow rate) / average flow rate).

[0059] S230: If the at least one target parameter satisfies the preset conditions, confirm that right heart failure exists.

[0060] After the target heart rate, target pumping flow, and target pulsatility index are calculated, they can be compared with corresponding thresholds to determine whether the current patient has right heart failure.

[0061] Optionally, the preset conditions are: the target heart rate is greater than or equal to n times the baseline heart rate, the target pumping flow is greater than or equal to m times the baseline pumping flow, the target pulsation index is greater than or equal to k times the baseline pulsation index, n is greater than 1, and m and k are greater than 0 and less than 1.

[0062] When a patient has right heart failure, cardiac output will be increased by increasing heart rate compensation, so the heart rate of patients with right heart failure will increase. In addition, right heart failure prevents the right ventricle from effectively pumping blood to the lungs, resulting in a decrease in overall blood flow, so the maximum flow rate will be relatively reduced. Moreover, the long-term operation of the ventricular assist device causes the load in the right ventricle to continue to increase, causing right heart enlargement, leftward shift of the right ventricular septum, and compression of the left heart, resulting in increased left ventricular pressure. This then reduces the pressure difference between the left ventricle and the aorta during diastole, reducing diastolic pumping resistance. Although the overall blood flow is reduced, the minimum pumping flow rate increases. The maximum flow rate decreases and the minimum flow rate increases, ultimately leading to a decrease in the pulsatility index.

[0063] The control device 200 can compare the target heart rate, target pumping flow and target pulsation index with their corresponding baseline data respectively. If the target heart rate increases, the target pumping flow decreases or the target pulsation index decreases, it is determined that the current patient has right heart failure.

[0064] Specifically, the control device 200 calculates a first difference between the target heart rate and the reference heart rate, a second difference between the reference pumping flow rate and the target pumping flow rate, and a third difference between the reference pulsation index and the target pulsation index, and then makes a judgment based on the target parameters.

[0065] If the target parameter is the target heart rate, and the target heart rate is greater than or equal to n times the baseline heart rate, the patient is considered to have right heart failure. If the target parameter is the target pump flow rate, and the target pump flow rate is greater than or equal to m times the baseline pump flow rate, the patient is considered to have right heart failure. If the target parameter is the target pulsation index, and the target pulsation index is greater than or equal to k times the baseline pulsation index, the patient is considered to have right heart failure.

[0066] If the target parameters include a target heart rate and a target pumping flow rate, then when the target heart rate is greater than or equal to n times the baseline heart rate and the target pumping flow rate is greater than or equal to m times the baseline pumping flow rate, the current patient is considered to have right heart failure. If the target parameters include a target heart rate and a target pulsation index, then when the target heart rate is greater than or equal to n times the baseline heart rate and the target pulsation index is greater than or equal to k times the baseline pulsation index, the current patient is considered to have right heart failure. If the target parameters include a target pumping flow rate and a target pulsation index, then when the target pumping flow rate is greater than or equal to m times the baseline pumping flow rate and the target pulsation index is greater than or equal to k times the baseline pulsation index, the current patient is considered to have right heart failure.

[0067] If the target parameters include target heart rate, target pumping flow and target pulsation index, then when the target heart rate is greater than or equal to n times the baseline heart rate, the target pumping flow is greater than or equal to m times the baseline pumping flow, and the target pulsation index is greater than or equal to k times the baseline pulsation index, the current patient is considered to have right heart failure.

[0068] The larger the n is and the smaller the m and k are, the more severe the right heart failure is.

[0069] The n, m, and k values ​​can be set based on the patient's specific physiological data and physical condition. n, m, and k values ​​can also be set based on clinical trial data. For example, the first value can be set to 1.2, the second value to 0.9, and the third value to 0.85.

[0070] In one possible example, the method further includes: obtaining a second pumping flow curve, which is the pumping flow of the ventricular assist device when the right heart is in a normal state; and determining the baseline heart rate, the baseline pumping flow, and the baseline pulsation index based on the second pumping flow curve.

[0071] The ventricular assist device is implanted in the patient's body through surgery, and the control device 200 obtains the running state of the ventricular assist device in real time after the ventricular assist device is started. The ventricular assist device can be implanted in the patient's body for long-term use. When the patient's body recovers to the discharge standard, it is considered that the current ventricular assist device can meet the pumping demand of the patient, and the patient's body reaches the normal state, that is, the pumping flow curve of the current ventricular assist device is the pumping flow curve of the patient in the normal state (the running of the ventricular assist device does not cause right heart failure), so the pumping flow curve of the patient when reaching the discharge state can be taken as the second pumping flow curve, and the heart rate, pumping flow and pulsatility index calculated from the second pumping flow curve are taken as the reference heart rate, reference pumping flow and reference pulsatility index respectively. Since the ventricular assist device runs at a constant speed, after the patient is discharged, by comparing the target parameters obtained from the pumping flow curve of the ventricular assist device with the parameters obtained from the pumping flow curve of the ventricular assist device at the time of discharge, the changes of the patient after discharge can be obtained, and then the influence of the running of the ventricular assist device on the left heart on the right heart can be determined.

[0072] It can be seen that the present application provides a right heart failure detection method, obtains a first pumping flow curve, the first pumping flow curve is a pumping flow curve in a target period when the ventricular assist device runs at a target rotating speed; at least one target parameter is determined according to the first pumping flow curve; if the at least one target parameter meets the preset condition, it is confirmed that there is right heart failure. The present application obtains the target parameters capable of measuring the state of the right heart from the pumping flow curve of the ventricular assist device implanted in the left heart in real time, and then determines whether the running of the current ventricular assist device causes right heart failure through comparison, thereby realizing real-time detection of right heart failure.

[0073] The above mainly introduces the scheme of the embodiments of the present application from the perspective of the execution process of the method. It can be understood that the network device contains the hardware structure and / or software module corresponding to the execution of each function in order to realize the above functions. Those skilled in the art should easily realize that the units and algorithm steps of each example described in connection with the embodiments provided in the present application can be realized in the form of hardware or a combination of hardware and computer software. Whether a certain function is realized in the form of hardware or computer software driving hardware depends on the specific application and design constraints of the technical solution. Professional technicians can use different methods to realize the described functions for each specific application, but such implementation should not be considered beyond the scope of the present application.

[0074] For example, the embodiments of the present application also provide a control circuit of a ventricular assist device, the ventricular assist device is used for the left heart, and the control circuit comprises one or more processors, and the one or more processors are used for:

[0075] acquiring a first pumping flow curve, where the first pumping flow curve is a pumping flow curve within a target cycle when the ventricular assist device operates at a target speed;

[0076] determining at least one target parameter according to the first pumping flow rate curve, wherein the target parameter is used to measure the state of the right heart;

[0077] If the at least one target parameter satisfies the preset conditions, it is confirmed that right heart failure exists.

[0078] For example, an embodiment of the present application provides a ventricular assist device for a left heart, comprising:

[0079] case;

[0080] an impeller disposed within the housing;

[0081] A motor driving the impeller to rotate in suspension;

[0082] The control circuit connected to the motor is used to execute part or all of the steps described in the above method.

[0083] For example, the present application also provides a medical device, which includes the control circuit or ventricular assist device described above.

[0084] Among them, the control unit of each of the above schemes has the function of implementing the corresponding steps performed by the medical device in the above method; the function can be implemented by hardware, or by hardware executing corresponding software implementation.

[0085] In the embodiment of the present application, the control circuit may also be a chip or a chip system, such as a system on chip (SoC).

[0086] See also Figure 4 , Figure 4 This is a structural diagram of a medical device provided in an embodiment of the present application, which includes: one or more processors, one or more memories, one or more communication interfaces, and one or more programs; the one or more programs are stored in the memory and are configured to be executed by the one or more processors.

[0087] The above program includes instructions for performing the following steps:

[0088] acquiring a first pumping flow curve, where the first pumping flow curve is a pumping flow curve within a target cycle when the ventricular assist device operates at a target speed;

[0089] determining at least one target parameter according to the first pumping flow rate curve, wherein the target parameter is used to measure the state of the right heart;

[0090] If the at least one target parameter satisfies the preset conditions, it is confirmed that right heart failure exists.

[0091] Among them, all relevant contents of each scenario involved in the above method embodiment can be referred to the functional description of the corresponding functional module, and will not be repeated here.

[0092] It should be understood that the above-mentioned memory may include read-only memory and random access memory, and provides instructions and data to the processor. A portion of the memory may also include non-volatile random access memory. For example, the memory may also store information about the device type.

[0093] In the embodiments of the present application, the processor of the above-mentioned device may be a central processing unit (CPU), and the processor may also be other general-purpose processors, digital signal processors (DSPs), application-specific integrated circuits (ASICs), field-programmable gate arrays (FPGAs) or other programmable logic devices, discrete gate or transistor logic devices, discrete hardware components, etc. The general-purpose processor may be a microprocessor or any conventional processor, etc.

[0094] It should be understood that the "at least one" involved in the embodiments of the present application refers to one or more, and "plurality" refers to two or more. "And / or" describes the association relationship of associated objects, indicating that three relationships may exist. For example, A and / or B can represent: the existence of A alone, the existence of A and B at the same time, and the existence of B alone, where A and B can be singular or plural. The character " / " generally indicates that the previous and subsequent associated objects are in an "or" relationship. "At least one of the following items" or similar expressions refers to any combination of these items, including any combination of single items or plural items. For example, at least one of a, b, or c can represent: a, b, c, ab, ac, bc, or abc, where a, b, c can be single or multiple.

[0095] Furthermore, unless otherwise indicated, ordinal numbers such as "first" and "second" in the embodiments of this application are used to distinguish multiple objects and are not used to define the order, timing, priority, or importance of multiple objects. For example, the first information and the second information are only used to distinguish different information and do not indicate differences in content, priority, transmission order, or importance between the two information.

[0096] During implementation, each step of the above method can be completed by an integrated logic circuit of hardware in a processor or by instructions in the form of software. The steps of the method disclosed in conjunction with the embodiments of the present application can be directly embodied as being executed by a hardware processor, or can be executed by a combination of hardware and software units in the processor. The software unit can be located in a storage medium mature in the art, such as a random access memory, a flash memory, a read-only memory, a programmable read-only memory, or an electrically erasable programmable memory, a register, etc. The storage medium is located in a memory, and the processor executes the instructions in the memory, and in combination with its hardware, completes the steps of the above method. To avoid repetition, a detailed description is not given here.

[0097] An embodiment of the present application also provides a computer storage medium, wherein the computer storage medium stores a computer program for electronic data exchange, and the computer program enables a computer to execute part or all of the steps of any method described in the above method embodiments.

[0098] The present application also provides a computer program product comprising a non-transitory computer-readable storage medium storing a computer program, wherein the computer program is operable to cause a computer to execute some or all of the steps of any of the methods described in the above method embodiments. The computer program product may be a software installation package.

[0099] It should be noted that for the aforementioned method embodiments, for the sake of simplicity, they are all expressed as a series of action combinations, but those skilled in the art should be aware that this application is not limited by the order of the actions described, because according to this application, certain steps can be performed in other orders or simultaneously. Secondly, those skilled in the art should also be aware that the embodiments described in the specification are all preferred embodiments, and the actions and modules involved are not necessarily required by this application.

[0100] In the above embodiments, the description of each embodiment has its own focus. For parts that are not described in detail in a certain embodiment, reference can be made to the relevant descriptions of other embodiments.

[0101] In the several embodiments provided in this application, it should be understood that the disclosed devices can be implemented in other ways. For example, the device embodiments described above are only schematic. For example, the division of the above-mentioned units is only a logical function division. In actual implementation, there may be other division methods, such as multiple units or components can be combined or integrated into another system, or some features can be ignored or not executed. Another point is that the mutual coupling or direct coupling or communication connection shown or discussed can be through some interfaces, and the indirect coupling or communication connection of devices or units can be electrical or other forms.

[0102] The units described above as separate components may or may not be physically separate, and the components shown as units may or may not be physical units, that is, they may be located in one place or distributed across multiple network units. Some or all of the units may be selected according to actual needs to achieve the purpose of the embodiments of the present application.

[0103] In addition, the functional units in the various embodiments of the present application may be integrated into a single processing unit, or each unit may exist physically separately, or two or more units may be integrated into a single unit. The aforementioned integrated units may be implemented in the form of hardware or software functional units.

[0104] If the above-mentioned integrated unit is implemented in the form of a software functional unit and sold or used as an independent product, it can be stored in a computer-readable memory. Based on this understanding, the technical solution of the present application is essentially or the part that contributes to the prior art or all or part of the technical solution can be embodied in the form of a software product. The computer software product is stored in a memory and includes several instructions for enabling a computer device (which can be a personal computer, server or TRP, etc.) to execute all or part of the steps of the various embodiments of the present application. The aforementioned memory includes: U disk, read-only memory (ROM, Read-Only Memory), random access memory (RAM, Random Access Memory), mobile hard disk, magnetic disk or optical disk and other media that can store program code.

[0105] Those skilled in the art will understand that all or part of the steps in the various methods of the above embodiments can be completed by instructing the relevant hardware through a program, and the program can be stored in a computer-readable memory, which may include: a flash drive, ROM, RAM, a magnetic disk or an optical disk, etc.

[0106] The above is a detailed introduction to the embodiments of the present application. Specific examples are used herein to illustrate the principles and implementation methods of the present application. The description of the above embodiments is only used to help understand the method and core idea of ​​the present application. At the same time, for those skilled in the art, according to the idea of ​​the present application, there may be changes in the specific implementation methods and application scope. In summary, the content of this specification should not be understood as a limitation on the present application.

Claims

1. A method for detecting right heart failure, characterized in that: Applied to a ventricular assist device, the ventricular assist device being used on the left side of the heart, the method comprising: acquiring a first pumping flow curve, where the first pumping flow curve is a pumping flow curve within a target cycle when the ventricular assist device operates at a target speed; determining at least one target parameter according to the first pumping flow rate curve, wherein the target parameter is used to measure the state of the right heart; If the at least one target parameter satisfies the preset conditions, it is confirmed that right heart failure exists.

2. The method according to claim 1, characterized in that The at least one target parameter includes a target heart rate; Determining at least one target parameter according to the first pumping flow curve includes: Performing a Fourier transform on the first pumping flow rate curve to obtain a target flow rate spectrum; The frequency with the maximum power in the target flow spectrum is determined as the target heart rate.

3. The method according to claim 2, characterized in that The at least one target parameter includes a target pumping flow rate; Determining at least one target parameter according to the first pumping flow curve includes: extracting the first pumping flow curve according to a preset sliding window; calculating the total pumping flow of the first pumping flow curve in each sliding window respectively; The average value of the total pumping flow rate is calculated to obtain the target pumping flow rate.

4. The method according to claim 3, characterized in that The at least one target parameter includes a target pulsatility index; Determining at least one target parameter according to the first pumping flow curve includes: Obtaining a maximum flow rate, a minimum flow rate, and an average flow rate of the first pumping flow rate curve; The target pulsation index is calculated according to the maximum flow rate, the minimum flow rate and the average flow rate.

5. The method according to claim 4, characterized in that The preset conditions are: a first difference between the target heart rate and the baseline heart rate is greater than or equal to a first value, a second difference between the baseline pumping flow and the target pumping flow is greater than or equal to a second value, and a third difference between the baseline pulsation index and the target pulsation index is greater than or equal to a third value, and the first value, the second value and the third value are all greater than 0 and less than 1.

6. The method according to claim 5, characterized in that The method further comprises: acquiring a second pumping flow curve, where the second pumping flow curve is the pumping flow of the ventricular assist device when the right heart is in a normal state; The reference heart rate, the reference pumping flow rate, and the reference pulsatility index are determined according to the second pumping flow rate curve.

7. The method according to any one of claims 5 or 6, characterized in that The larger the first difference, the second difference, and the third difference, the more severe the right heart failure.

8. A control circuit for a ventricular assist device, characterized in that: The ventricular assist device is used for the left heart, and the control circuit includes one or more processors, and the one or more processors are used to: acquiring a first pumping flow curve, where the first pumping flow curve is a pumping flow curve within a target cycle when the ventricular assist device operates at a target speed; determining at least one target parameter according to the first pumping flow rate curve, wherein the target parameter is used to measure the state of the right heart; If the at least one target parameter satisfies the preset conditions, it is confirmed that right heart failure exists.

9. A ventricular assist device for the left heart, characterized in that: include: case; an impeller disposed within the housing; A motor driving the impeller to rotate in suspension; The control circuit connected to the motor is used to perform the steps in the method according to any one of claims 1 to 7.

10. A medical device, characterized in that: The method comprises a processor, a memory and a communication interface, wherein the memory stores one or more programs, and the one or more programs are executed by the processor, and the one or more programs include instructions for executing the steps in the method according to any one of claims 1 to 7.

11. A computer-readable storage medium, characterized in that The computer-readable storage medium stores a computer program for electronic data exchange, wherein the computer program enables a computer to execute the steps of the method according to any one of claims 1 to 7.

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