Preparation method of traditional Chinese medicine composition for treating pulmonary abscess

Abstract

The invention relates to a preparation method of a traditional Chinese medicine composition for treating pulmonary abscess, which can effectively solve the problem of medication for treating pulmonary abscess. The oral liquid is prepared from the following raw material medicines: fresh rehmannia, fresh houttuynia cordata, fresh scutellaria baicalensis, fresh ginseng and gecko, and is prepared by cleaning, slicing, water adding, wall breaking, filtering, centrifuging, ultrafiltration, concentrating, freeze-drying, crushing, sieving, uniform mixing, vacuum packaging and sterilizing. The traditional Chinese medicine composition is prepared through a specific method according to the main and secondary relation of monarch, minister, assistant and guide, plays a synergistic effect, has the effects of clearing away lung-heat and detoxifying, dispersing blood stasis and eliminating carbuncle, strengthening the body resistance to eliminate pathogenic factors, and removing stasis and dredging collaterals, can be effectively used for treating pulmonary abscess, is simple in preparation method, convenient to operate, safe and environment-friendly, can keep active ingredients in the traditional Chinese medicines to the greatest extent, and has a remarkable curative effect on treating pulmonary abscess. The traditional Chinese medicine composition is free of toxic and side effects, has very good practical clinical application value and development and application prospects, and has huge economic and social benefits.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of traditional Chinese medicine, and particularly relates to a preparation method of a traditional Chinese medicine composition for treating lung abscess. BACKGROUND

[0002] Lung abscess is caused by wind-heat pathogenic toxin stagnating in the lung, heat blocking blood stasis, lung lobe forming sores, and forming abscess. Clinically, the main symptoms are cough, chest pain, and expectoration of foul-smelling purulent sputum, and even pus and blood. Some stages of lung cancer, pyogenic pneumonia, bronchiectasis, and pulmonary abscess are often attributed to lung abscess. Therefore, it is of great significance to develop a lung abscess prescription for the diagnosis and treatment of respiratory diseases. The existing drugs for treating lung abscess are mainly western antibiotics, which are easy to produce drug resistance and toxic side effects after long-term use. Traditional Chinese medicine has rich experience in treating this disease, and many effective prescriptions have been created by physicians of past dynasties. Many of these prescriptions have been used in clinical practice for a long time. They are often used for clearing heat and resolving toxins, and treating diseases according to syndrome differentiation, and can often relieve some symptoms, but the effect is slow and the recurrence rate is high.

[0003] Traditional Chinese medicine fresh medicine has unique curative effect in the treatment of acute and critical diseases and difficult and complicated diseases in traditional Chinese medicine clinical treatment, and its efficacy is better than that of dry medicine. Therefore, can fresh medicinal materials be used to develop a traditional Chinese medicine composition for treating lung abscess? So far, there has been no public report. SUMMARY

[0004] In view of the above situation, in order to overcome the shortcomings of the prior art, the purpose of the present application is to provide a preparation method of a traditional Chinese medicine composition for treating lung abscess, which can effectively solve the problem of using medicine to treat lung abscess.

[0005] The technical solution solved by the present application is a preparation method of a traditional Chinese medicine composition for treating lung abscess. The traditional Chinese medicine composition is prepared from the following raw medicinal materials by weight fraction: fresh rehmannia 3-10 parts, fresh houttuynia cordata 3-10 parts, fresh scutellaria baicalensis 3-7 parts, fresh ginseng 3-10 parts, and gecko 0.1-0.5 parts. The preparation method is as follows:

[0006] (1) The fresh rehmannia is selected and washed 1-3 times, and then cut into pieces or slices while fresh. Water with an original drug weight volume ratio of 0.5-4 times is added, the weight volume ratio is kg for solid and L for liquid (hereinafter the same), the wall is broken for 1-10 min, filtered, and the filtrate is centrifuged at 2000-8000 r / min for 5-30 min to obtain the first supernatant. Then, water is added again, and the wall is broken and centrifuged according to the above method for 1-4 times to obtain the second to fifth supernatants, and the supernatants of each time are combined;

[0007] The fresh houttuynia cordata is selected and washed 1-3 times, and then cut into sections while fresh. Water with an original drug weight volume ratio of 1-5 times is added, the wall is broken for 1-10 min, filtered, and the filtrate is centrifuged at 2000-8000 r / min for 5-30 min to obtain the first supernatant. Then, water is added again, and the wall is broken and centrifuged according to the above method for 1-4 times to obtain the second to fifth supernatants, and the supernatants of each time are combined;

[0008] Fresh Huangqi is selected and washed 1-3 times, and then cut into sections or slices. Water is added to the sections or slices at a weight volume ratio of 0.5-4 times that of the original medicine, and the sections or slices are broken for 1-20 min. The filtrate is centrifuged at 2000-8000 r / min for 5-30 min to obtain a first supernatant. Then, water is added again, and the sections or slices are broken and centrifuged according to the above method for 1-4 times to obtain a second to fifth supernatant. The supernatants are combined.

[0009] Fresh Huangqi is selected and washed 1-3 times, and then cut into sections or slices. Water is added to the sections or slices at a weight volume ratio of 0.5-4 times that of the original medicine, and the sections or slices are broken for 1-20 min. The filtrate is centrifuged at 2000-8000 r / min for 5-30 min to obtain a first supernatant. Then, water is added again, and the sections or slices are broken and centrifuged according to the above method for 1-4 times to obtain a second to fifth supernatant. The supernatants are combined.

[0010] (2) The supernatants of the fresh Rehmannia glutinosa, Houttuynia cordata, fresh Huangqi, and fresh Panax ginseng are separately subjected to ultrafiltration with a 10000D ultrafiltration membrane to remove macromolecular substances. The ultrafiltration permeate is collected, and then subjected to concentration with a 200D nanofiltration membrane to obtain a nanofiltration concentrate. Then, the nanofiltration concentrate is freeze-dried to obtain a freeze-dried powder.

[0011] (3) The wall gecko medicinal material is washed, cut into sections, and then freeze-dried. The freeze-dried material is first crushed into coarse powder, and then passed through an 80-100 mesh sieve. The coarse powder is then subjected to ultrafine pulverization, and then passed through a 100-300 mesh sieve to obtain wall gecko ultrafine powder.

[0012] (4) The freeze-dried powders obtained in step (2) and the wall gecko ultrafine powder obtained in step (3) are uniformly mixed, vacuum packaged, and sterilized to obtain a finished product of the traditional Chinese medicine composition for treating lung abscess. The finished product is stored at -20°C for standby use. The sterilization method includes, but is not limited to, ultra-high pressure sterilization, pasteurization, radiation sterilization, gas sterilization, and filtration sterilization.

[0013] The traditional Chinese medicine composition prepared by the method is used for the preparation of a medicine for treating lung abscess.

[0014] The traditional Chinese medicine composition prepared by the method is further added with a pharmaceutically acceptable excipient to prepare different traditional Chinese medicine dosage forms.

[0015] The traditional Chinese medicine dosage form is a granule, a tablet, or a capsule.

[0016] The traditional Chinese medicine composition prepared by the method is used for the preparation of a medicine for preventing and relieving lung abscess.

[0017] The traditional Chinese medicine composition in the application is prepared according to the primary and secondary relationship of monarch, minister, assistant and guide by a specific method, has the effects of clearing lung, resolving toxin, resolving stasis and eliminating carbuncle, and has the effects of supporting healthy qi and eliminating pathogenic factors and resolving stasis and dredging collaterals, can be effectively used for treating lung abscess, has simple preparation method, convenient operation, safety and environmental protection, can retain the active ingredients in traditional Chinese medicine to the maximum extent, ensures the effects of the medicine, has no toxic side effects, has good practical clinical application value and development and application prospect, and has huge economic and social benefits. DETAILED DESCRIPTION

[0018] The specific embodiments of the application are described in detail below in combination with examples and specific cases.

[0019] Example 1

[0020] The preparation method of the traditional Chinese medicine composition for treating lung abscess is prepared from the following raw materials by weight fraction: fresh rehmannia 5 parts, fresh hedychnum 7 parts, fresh scrophularia 5 parts, fresh ginseng 7 parts and wall gecko 0.5 part, and the preparation method is as follows:

[0021] (1) The fresh rehmannia is selected and washed twice, and then cut into pieces or 2-4 mm thick pieces, 1 times the weight of the original medicine is added to water, the wall is broken for 2.5 min, filtered, and the filtrate is centrifuged at 4000 r / min for 20 min to obtain the first supernatant; then 3 times the amount of water is added and the wall is broken and centrifuged twice according to the above method to obtain the second and third supernatants, and the supernatants are combined;

[0022] The fresh hedychnum is selected and washed twice, and then cut into segments, 2 times the weight of the original medicine is added to water, the wall is broken for 5 min, filtered, and the filtrate is centrifuged at 4000 r / min for 20 min to obtain the first supernatant; then 4 times the amount of water is added and the wall is broken and centrifuged twice according to the above method to obtain the second and third supernatants, and the supernatants are combined;

[0023] The fresh scrophularia is selected and washed twice, and then cut into segments or 2-4 mm thick pieces, 2 times the weight of the original medicine is added to water, the wall is broken for 8 min, filtered, and the filtrate is centrifuged at 4000 r / min for 20 min to obtain the first supernatant; then 4 times the amount of water is added and the wall is broken and centrifuged twice according to the above method to obtain the second and third supernatants, and the supernatants are combined;

[0024] The fresh ginseng is selected and washed twice, and then cut into segments or 2-4 mm thick pieces, 1 times the weight of the original medicine is added to water, the wall is broken for 8 min, filtered, and the filtrate is centrifuged at 4000 r / min for 20 min to obtain the first supernatant; then 3 times the amount of water is added and the wall is broken and centrifuged twice according to the above method to obtain the second and third supernatants, and the supernatants are combined;

[0025] (2) The supernatant of the fresh Rehmannia glutinosa, the fresh Houttuynia cordata, the fresh Scutellaria baicalensis and the fresh Panax ginseng is respectively ultrafiltrated by a 10000D ultrafiltration membrane to remove macromolecular substances, and each ultrafiltration permeate is collected and concentrated by a 200D nanofiltration membrane to obtain each nanofiltration concentrate; then each nanofiltration concentrate is freeze-dried to collect each freeze-dried substance, which is crushed to obtain each freeze-dried powder;

[0026] (3) The wall gecko medicinal material is washed, cut into segments, freeze-dried, crushed into coarse powder, passed through a 100-mesh sieve, and then ultra-micro-pulverized and passed through a 300-mesh sieve to obtain wall gecko ultra-micro-powder;

[0027] (4) The freeze-dried powders obtained in step (2) and the wall gecko ultra-micro-powder obtained in step (3) are uniformly mixed, vacuum-packaged, and sterilized to obtain the traditional Chinese medicine composition for treating lung abscess.

[0028] Example 2:

[0029] The preparation method of the traditional Chinese medicine composition for treating lung abscess is as follows: 7 parts of fresh Rehmannia glutinosa, 7 parts of fresh Houttuynia cordata, 7 parts of fresh Scutellaria baicalensis, 10 parts of fresh Panax ginseng and 0.3 parts of wall gecko are used as raw medicinal materials, and the preparation method is as follows:

[0030] (1) The fresh Rehmannia glutinosa is selected, washed twice, cut into pieces, and added with water in an amount of 3 times the weight of the original medicine, and broken for 5 min, filtered, and the filtrate is centrifuged at 6000 r / min for 15 min to obtain the first supernatant; then the above method is repeated once more to obtain the second supernatant, and the supernatants are combined;

[0031] The fresh Houttuynia cordata is selected, washed twice, cut into segments, and added with water in an amount of 4 times the weight of the original medicine, and broken for 5 min, filtered, and the filtrate is centrifuged at 6000 r / min for 15 min to obtain the first supernatant; then the above method is repeated once more to obtain the second supernatant, and the supernatants are combined;

[0032] The fresh Scutellaria baicalensis is selected, washed twice, cut into segments, and added with water in an amount of 4 times the weight of the original medicine, and broken for 10 min, filtered, and the filtrate is centrifuged at 6000 r / min for 15 min to obtain the first supernatant; then the above method is repeated once more to obtain the second supernatant, and the supernatants are combined;

[0033] The fresh Panax ginseng is selected, washed twice, cut into segments, and added with water in an amount of 3 times the weight of the original medicine, and broken for 10 min, filtered, and the filtrate is centrifuged at 6000 r / min for 15 min to obtain the first supernatant; then the above method is repeated once more to obtain the second supernatant, and the supernatants are combined;

[0034] (2) The supernatant of the fresh Rehmannia glutinosa, the fresh Houttuynia cordata, the fresh Scutellaria baicalensis and the fresh Panax ginseng is respectively ultra-filtered by a 10000D ultra-filter membrane to remove macromolecular substances, each ultra-filtered permeate is collected, and each nanofiltration concentrate is obtained by concentrating each ultra-filtered permeate by a 200D nanofiltration membrane; then each nanofiltration concentrate is freeze-dried, each freeze-dried substance is collected, and each freeze-dried powder is obtained by crushing;

[0035] (3) The wall gecko medicinal material is washed, cut into segments, freeze-dried, crushed into coarse powder, passed through a 100-mesh sieve, and then ultra-micro-pulverized and passed through a 220-mesh sieve to obtain wall gecko ultra-micro-powder;

[0036] (4) The freeze-dried powder obtained in step (2) and the wall gecko ultra-micro-powder obtained in step (3) are uniformly mixed, vacuum-packaged, sterilized, and the finished product of the traditional Chinese medicine composition for treating lung abscess is obtained.

[0037] Example 3:

[0038] The preparation method of the traditional Chinese medicine composition for treating lung abscess is as follows: 10 parts of fresh Rehmannia glutinosa, 10 parts of fresh Houttuynia cordata, 7 parts of fresh Scutellaria baicalensis, 10 parts of fresh Panax ginseng and 0.5 parts of wall gecko are used as raw medicinal materials, and the preparation method is as follows:

[0039] (1) The fresh Rehmannia glutinosa is selected and washed once, and then cut into 2-4 mm thick slices, 4 times the weight of the original medicine by volume of water is added, the wall is broken for 10 minutes, filtered, and the filtrate is centrifuged at 6000 r / min for 30 minutes to obtain the supernatant;

[0040] The fresh Houttuynia cordata is selected and washed once, and then cut into segments, 5 times the weight of the original medicine by volume of water is added, the wall is broken for 10 minutes, filtered, and the filtrate is centrifuged at 6000 r / min for 30 minutes to obtain the supernatant;

[0041] The fresh Scutellaria baicalensis is selected and washed once, and then cut into 2-4 mm thick slices, 5 times the weight of the original medicine by volume of water is added, the wall is broken for 20 minutes, filtered, and the filtrate is centrifuged at 6000 r / min for 30 minutes to obtain the supernatant;

[0042] The fresh Panax ginseng is selected and washed once, and then cut into 2-4 mm thick slices, 4 times the weight of the original medicine by volume of water is added, the wall is broken for 20 minutes, filtered, and the filtrate is centrifuged at 6000 r / min for 30 minutes to obtain the supernatant;

[0043] (2) The supernatant of the fresh Rehmannia glutinosa, the fresh Houttuynia cordata, the fresh Scutellaria baicalensis and the fresh Panax ginseng is respectively ultra-filtered by a 10000D ultra-filter membrane to remove macromolecular substances, each ultra-filtered permeate is collected, and each nanofiltration concentrate is obtained by concentrating each ultra-filtered permeate by a 200D nanofiltration membrane; then each nanofiltration concentrate is freeze-dried, each freeze-dried substance is collected, and each freeze-dried powder is obtained by crushing;

[0044] (3) the wall gecko medicinal material is washed, cut into sections, and then freeze-dried, crushed into coarse powder, passed through an 80-mesh sieve, and then ultra-micropulverized and passed through a 100-mesh sieve to obtain wall gecko ultra-micropowder;

[0045] (4) the freeze-dried powder obtained in step (2) and the wall gecko ultra-micropowder obtained in step (3) are uniformly mixed, vacuum packaged, and sterilized to obtain the finished product of the traditional Chinese medicine composition for treating lung abscess.

[0046] Example 4:

[0047] The present application discloses a preparation method of a traditional Chinese medicine composition for treating lung abscess, which is prepared from the following raw medicinal materials in parts by weight: fresh rehmannia 3 parts, fresh hedychni 5 parts, fresh scrophulariaceae 3 parts, fresh ginseng 5 parts, and wall gecko 0.1 part.

[0048] (1) the fresh rehmannia root is selected, washed for 2 times, cut into sections, and then added with water in an amount of 0.5 times the weight of the raw medicine, and broken for 5 min, filtered, and the filtrate is centrifuged at 2000 r / min for 30 min to obtain the first supernatant; then water in an amount of 3 times the weight of the raw medicine is added, and broken for 2.5 min, filtered, and the filtrate is centrifuged at 4000 r / min for 15 min to obtain the second supernatant; and the above-mentioned method is repeated for 2 times to obtain the third to fourth supernatants, and the supernatants are combined;

[0049] the hedychni is selected, washed for 2 times, cut into sections, and then added with water in an amount of 1 times the weight of the raw medicine, and broken for 5 min, filtered, and the filtrate is centrifuged at 2000 r / min for 30 min to obtain the first supernatant; then water in an amount of 3 times the weight of the raw medicine is added, and broken for 2.5 min, filtered, and the filtrate is centrifuged at 4000 r / min for 15 min to obtain the second supernatant; and the above-mentioned method is repeated for 2 times to obtain the third to fourth supernatants, and the supernatants are combined;

[0050] the fresh scrophulariaceae is selected, washed for 1-3 times, cut into sections or slices, and then added with water in an amount of 1 times the weight of the raw medicine, and broken for 10 min, filtered, and the filtrate is centrifuged at 2000 r / min for 30 min to obtain the first supernatant; then water in an amount of 3 times the weight of the raw medicine is added, and broken for 5 min, filtered, and the filtrate is centrifuged at 4000 r / min for 15 min to obtain the second supernatant; and the above-mentioned method is repeated for 2 times to obtain the third to fourth supernatants, and the supernatants are combined;

[0051] The fresh ginseng is cleaned for 1-3 times, and is cut into sections or slices while fresh, water with a volume of 0.5 times of the weight of the raw medicine is added, and the wall is broken for 10 minutes, and then filtered, and the filtrate is centrifuged at 2000 r / min for 30 minutes to obtain the first supernatant; then water with a volume of 3 times of the weight of the raw medicine is added, and the wall is broken for 5 minutes, and then filtered, and the filtrate is centrifuged at 4000 r / min for 15 minutes to obtain the second supernatant, and then the wall is broken and centrifuged for 2 times according to the above method by adding water to obtain the third and fourth supernatants, and the supernatants are combined;

[0052] (2) The supernatants of the fresh rehmannia, the fishy-smelling grass, the fresh scrophulariaceae and the fresh ginseng are respectively subjected to ultrafiltration by using a 10000D ultrafiltration membrane to remove macromolecular substances, and the ultrafiltration permeate is collected, and then concentrated by using a 200D nanofiltration membrane to obtain a nanofiltration concentrate; then the nanofiltration concentrate is freeze-dried, and the freeze-dried product is collected and pulverized to obtain a freeze-dried powder;

[0053] (3) The gecko medicinal material is cleaned, cut into sections, freeze-dried, and then pulverized into a coarse powder, and then the coarse powder is passed through a 100-mesh sieve and then subjected to ultrafine pulverization to pass through a 280-mesh sieve to obtain a gecko ultrafine powder;

[0054] (4) The freeze-dried powder obtained in step (2) and the gecko ultrafine powder obtained in step (3) are uniformly mixed, vacuum packaged, and sterilized to obtain a finished product of the traditional Chinese medicine composition for treating lung abscess.

[0055] Example 5:

[0056] The preparation method of the traditional Chinese medicine composition for treating lung abscess is as follows: 9 parts of fresh rehmannia, 3 parts of fresh fishy-smelling grass, 6 parts of fresh scrophulariaceae, 3 parts of fresh ginseng and 0.2 parts of gecko are used as raw medicinal materials, and the preparation method is as follows:

[0057] (1) The fresh rehmannia is cleaned for 3 times, and is cut into sections while fresh, water with a volume of 2 times of the weight of the raw medicine is added, and the wall is broken for 5 minutes, and then filtered, and the filtrate is centrifuged at 8000 r / min for 5 minutes to obtain the first supernatant; then water is added, and the wall is broken and centrifuged for 4 times according to the above method to obtain the second to fifth supernatants, and the supernatants are combined;

[0058] The fresh fishy-smelling grass is cleaned for 3 times, and is cut into sections while fresh, water with a volume of 2 times of the weight of the raw medicine is added, and the wall is broken for 3 minutes, and then filtered, and the filtrate is centrifuged at 8000 r / min for 5 minutes to obtain the first supernatant; then water is added, and the wall is broken and centrifuged for 4 times according to the above method to obtain the second to fifth supernatants, and the supernatants are combined;

[0059] The fresh scrophulariaceae is cleaned for 3 times, and is cut into sections while fresh, water with a volume of 2 times of the weight of the raw medicine is added, and the wall is broken for 10 minutes, and then filtered, and the filtrate is centrifuged at 8000 r / min for 5 minutes to obtain the first supernatant; then water is added, and the wall is broken and centrifuged for 4 times according to the above method to obtain the second to fifth supernatants, and the supernatants are combined;

[0060] The fresh ginseng is washed for 3 times after selection, cut into sections, and broken for 8 minutes with 2 times the weight of the raw medicine in volume of water. The filtrate is centrifuged at 8000 r / min for 5 minutes to obtain the first supernatant. Then, the water is added again and the above method is repeated for 4 times to obtain the second to fifth supernatants. The supernatants are combined.

[0061] (2) The supernatants of the fresh rehmannia, the fresh houttuynia cordata, the fresh scrophularia ningpoensis and the fresh ginseng are respectively ultrafiltrated with a 10000D ultrafiltration membrane to remove macromolecular substances. The ultrafiltration permeate is collected and concentrated with a 200D nanofiltration membrane to obtain a nanofiltration concentrate. Then, the nanofiltration concentrate is freeze-dried to obtain a freeze-dried powder.

[0062] (3) The wall gecko medicinal material is washed, cut into sections, and freeze-dried. The freeze-dried wall gecko medicinal material is first crushed into coarse powder, then passed through an 80-mesh sieve, and then ultra-finely crushed and passed through a 180-mesh sieve to obtain wall gecko ultra-fine powder.

[0063] (4) The freeze-dried powder obtained in step (2) and the wall gecko ultra-fine powder obtained in step (3) are uniformly mixed, vacuum packaged, and sterilized to obtain the finished product of the traditional Chinese medicine composition for treating lung abscess.

[0064] The application of the traditional Chinese medicine composition prepared by the method in the preparation of a medicine for treating lung abscess.

[0065] The traditional Chinese medicine composition prepared by the method is added with a pharmaceutically acceptable auxiliary to prepare different traditional Chinese medicine dosage forms.

[0066] The traditional Chinese medicine dosage form is a granule, a tablet, a capsule, or a pharmaceutically acceptable dosage form.

[0067] The application of the traditional Chinese medicine composition prepared by the method in the preparation of a medicine for preventing and relieving lung abscess.

[0068] The traditional Chinese medicine composition, wherein:

[0069] Fresh rehmannia: sweet and bitter in taste, cold in nature. It belongs to heart, liver and kidney channels. It can clear heat, produce saliva, cool blood and stop bleeding.

[0070] Fresh houttuynia cordata: pungent in taste, slightly cold in nature. It belongs to lung channel. It can clear heat and resolve toxicity, and can resolve abscess and discharge pus.

[0071] Fresh scrophularia ningpoensis: bitter in taste, cold in nature. It belongs to lung, gallbladder, spleen, large intestine and small intestine channels. It can clear heat, dry dampness, resolve toxicity, and stop bleeding.

[0072] Fresh ginseng: sweet and slightly bitter in taste, slightly warm in nature. It belongs to spleen, lung, heart and kidney channels. It can tonify the vital energy, restore pulse, supplement the spleen and lung, produce saliva, nourish blood, calm the mind and improve intelligence.

[0073] Wall gecko: salty in taste, cold in nature. It belongs to liver channel. It can dispel wind, calm the mind, resolve toxicity and remove knots.

[0074] The above components are scientifically and reasonably matched according to the primary and secondary compatibility principle of Chinese medicine monarch, minister, assistant and guide, and play a role in mutual cooperation. Fresh Houttuynia cordata has the effects of clearing heat and resolving toxin and eliminating carbuncle and pus, and can clear heat and resolve toxin and promote the discharge of carbuncle pus according to the pathological characteristics of lung carbuncle caused by heat and toxin accumulation in the lung and blood decay and meat corruption into carbuncle, so it is the monarch drug. Fresh Scutellaria baicalensis has the effects of clearing heat and resolving toxin and purging fire and resolving toxin, and can eliminate heat and toxin in the lung and assist in enhancing the effect of fresh Houttuynia cordata in clearing heat and resolving toxin, and fresh Rehmannia glutinosa has the effects of clearing heat and cooling blood and nourishing yin and generating fluid, which can help to clear heat and toxin in the lung by nourishing yin and clearing heat, and prevent excessive heat and toxin from consuming yin fluid, so fresh Scutellaria baicalensis and fresh Rehmannia glutinosa are the minister drugs. Fresh Panax ginseng is the assistant, which can tonify primordial qi, tonify the spleen and benefit the lung, thereby supporting the body's healthy qi and enhancing the body's resistance to diseases, preventing the damage of healthy qi caused by excessive heat and toxin, and repairing the symptoms of qi deficiency caused by the long-term invasion of heat and toxin, so as to achieve the effect of supporting healthy qi and eliminating pathogenic factors. Gecko has the effects of dispelling wind and calming shock and resolving toxin and is the guide drug, which can help the main drugs to dissipate lung carbuncle and phlegm, and the combination of the above drugs can tonify qi, consolidate the body, nourish yin and clear heat, generate fluid and clear heat and purge fire, which can be effectively used for the treatment of lung carbuncle and has achieved very good technical effects. The relevant test data are as follows (taking Example 1 as an example):

[0075] 1. Case selection

[0076] Lung carbuncle refers to a disease characterized by lung abscess, blood decay and meat corruption into carbuncle, fever, cough, chest pain, and the main clinical manifestations of yellow-green pus sputum or blood sputum, which is a kind of disease syndrome. Those with the above clinical symptoms are selected as the source of cases.

[0077] 2. Diagnostic criteria

[0078] 2.1. Refer to the Chinese Medicine Industry Standard of the People's Republic of China, Diagnosis and Treatment Criteria for Internal Medicine Syndromes of Traditional Chinese Medicine (ZY / T001.1-94): ① The disease usually occurs suddenly, often with sudden high fever, cough, chest pain, and heavy breathing. ② A large amount of yellow-green pus sputum or blood sputum is coughed up, and the smell is foul. ③ Local percussion presents dullness, and respiratory sound is reduced or enhanced, and speech vibration sound is enhanced, and bronchial breathing sound or wet rale can be heard. ④ The total number of white blood cells and neutrophils is increased. ⑤ Bacterial culture of sputum shows pathogenic bacteria. ⑥ Chest X-ray shows large and dense inflammatory shadows in the lung, or transparent area and liquid level.

[0079] 2.2. Inclusion criteria

[0080] ① Those who meet the clinical diagnosis of bronchiectasis combined with infection (lung carbuncle); ② Those who meet the requirements of medical ethics; ③ Those who agree and can tolerate bronchial fibroscopy.

[0081] 2.3. Exclusion criteria

[0082] ① Not in accordance with diagnostic criteria and inclusion criteria; ② In accordance with inclusion criteria, various complications, various adverse reactions and other serious adverse events during treatment must be terminated or changed.

[0083] 3. Treatment regimen

[0084] A total of 50 cases were observed, including 25 males and 25 females, aged 40-73 years.

[0085] The diagnosed patients were set in the experimental group and the control group in the experiment, and 50 cases were randomly divided into two groups (the experimental group and the control group), 25 people in each group. The experimental group received the traditional Chinese medicine composition of the application, and took it twice a day, morning and evening, for 20 days in a row; the control group received lung lavage by bronchoscopy.

[0086] Experimental group: The traditional Chinese medicine composition of the application was used, twice a day, taken with warm water, 3g (6 pills) each time.

[0087] Control group: Fishy grass injection and distilled water were mixed at a ratio of 1:1, 10-20mL each time, and lung lavage was performed by bronchoscopy, with a total amount of not more than 100mL; precautions: try to aspirate the secretions in the trachea and bronchus before lung lavage; during bronchial lung lavage, the patient's heart rate, heart rate, blood oxygen saturation and other indicators should be observed, and if obvious hypoxemia or arrhythmia occurs, the perfusion should be stopped.

[0088] 1 course is 20 days, and the curative effect is observed after 1 course of treatment.

[0089] 4. Efficacy evaluation criteria

[0090] Marked effect: After treatment, cough is significantly reduced, sputum volume is significantly reduced, sputum is clear and easy to cough out. Chest X-ray shows that lung shadow is obviously absorbed. Lung function detection FEV and Ve are improved.

[0091] Effective: After treatment, various symptoms are relieved, such as reduced cough and reduced purulent sputum, and chest X-ray and lung function are improved.

[0092] Invalid: Various symptoms, chest X-ray and lung function are not improved, and even have a tendency to aggravate.

[0093] 5. Statistical processing

[0094] Case data: 50 outpatients were selected and randomly divided into treatment group and control group in a ratio of 1:1, 25 cases in each group: 25 females and 25 males in the treatment group, aged 40-71 years. 25 females and 25 males in the control group, aged 42-73 years. There was no significant difference in gender, age, disease duration and other general data between the two groups (P>0.05) by statistical analysis, which was comparable.

[0095] The effects of treating lung abscess are shown in Table 1.

[0096] Table 1 Comparison of clinical efficacy between the two groups of patients [n (%)]

[0097]

[0098] The experimental results show that the total effective rate of the Chinese medicine composition of the present invention in treating lung abscess is 96%, and the significant effective rate is 76%; the total effective rate of the control group in treating lung abscess is 92%, and the significant effective rate is 44%, which is much higher than that of the control group, indicating that the pharmaceutical composition of the present invention has a good effect in treating lung abscess, and the therapeutic effect is significantly better than that of the control group.

[0099] 6. Typical cases:

[0100] Case 1: Mr. Sun, a 54-year-old male from XX City, Henan Province, first developed a cough and chest discomfort over two months ago. Recently, his cough has worsened, along with mild wheezing, turbid and foul-smelling sputum, sometimes bloody, and chest and rib pains, with slight chills and fever, poor sleep and appetite, dark yellow urine, dry stools, and a slippery and rapid pulse.

[0101] After taking the Chinese medicine composition of the present invention for 2 days, the fever and chills have subsided, the wheezing has stopped, and after taking it for 7 days, the cough is lighter, the sputum is reduced but still smelly, and there is no blood, the sleep and appetite are better, and the bowel movements are normal. After taking it for 14 days, all symptoms are lighter, but the patient still feels short of breath and tired, and the sleep and appetite are not as usual. The symptoms have improved greatly. After taking it for 20 days, all symptoms have disappeared and the patient can live a normal life.

[0102] Case 2: Wang, female, 50 years old, from XX City, Henan Province. She had a fever for a week, with a temperature of 38.3°C, cough, headache, and persistent sputum. She had taken loquat dew cough syrup, compound licorice mixture, and fresh bamboo sap oral liquid, but the cough and fever persisted. This morning, she developed a cough and chest pain, vomited several mouthfuls of pus and blood, which was foul-smelling and sticky, had chest and flank pain, had slightly dry stools, scant yellow urine, felt irritable and thirsty, had a yellow, greasy tongue coating, and was red and dry. Both pulses were stringy, slippery, and rapid.

[0103] After taking the Chinese medicine composition of the present invention for 2 days, the fever gradually subsided, the body temperature was 37.2 ° C, the cough gradually subsided, and the blood in sputum was also light. After taking it for 5 days, the fever had subsided, the body temperature was 36.7 ° C, the cough was greatly reduced, the sputum was very little, there was no blood and pus odor, and the chest pain gradually stopped. After taking it for 14 days, the cough basically disappeared, the blood and pus odor sputum was no longer vomited, and the chest pain stopped. After taking it for 20 days, all symptoms were relieved, the diet and bowel movements were normal, and the chest X-ray was normal.

[0104] Case 3: Mr. Li, male, 43 years old, from XX City, Henan Province. He is a heavy smoker with a history of cough and asthma. Two months ago, he caught a cold and developed a fever, which exacerbated his cough. His sputum contained pus and had a fishy odor. He received Western medicine anti-inflammatory injections and Chinese patent medicines for clearing the lungs and resolving phlegm. His cough and sputum symptoms sometimes improved slightly and sometimes worsened. When he came to the clinic, he had abnormal brain tightness and pain, and he occasionally produced turbid and fishy sputum. He had a dry throat but no thirst. His pulse was rapid and his tongue was yellow.

[0105] After taking the Chinese medicine composition of the present application for 4 days, the cough was alleviated, the chest tightness and pain were relieved, after taking for 15 days, the cough was greatly alleviated, the chest tightness was reduced, the pain disappeared, the sputum amount was reduced, the sputum was thin and yellow in color, and the odor was reduced, the symptoms were greatly improved, the patient's spirit gradually recovered, after taking for 2 months, the symptoms disappeared, the patient lived normally, and no recurrence was found in the follow-up.

[0106] Case 4: Li, female, 47 years old, Henan XX city, cough and fever for several days, after taking antibiotics for 3 days, the fever did not subside, then found that the patient's sputum was smelly and the color was like pus, took Chinese herbal medicine such as white yam and fishy grass for several days, the disease did not improve obviously, the fever reached 39.2℃, aversion to cold, pulse string tight and slippery number force, tongue fur white and thick, tongue quality light and moist;

[0107] After taking the Chinese medicine composition of the present application for 5 days, the high fever basically subsided, the body temperature was 37.7℃, the cough was alleviated, after taking for 15 days, the cough was greatly alleviated, the body temperature was normal, the sputum was not bloody, and the odor was reduced, the patient felt comfortable in the lungs, after taking for 20 days, the patient recovered to normal, and no recurrence was found so far.

[0108] Case 5: Zhou, male, 42 years old, Henan XXX city, fever 39.3℃ since yesterday, cough and sputum sticky, not easy to cough out, today's body heat burns hands, sweat drenches clothes, cough and right chest pain, cough and yellow pus smelly sputum. Chest X-ray: right upper lobe of lung abscess, empty cavity liquid flat formation. Blood test: white blood cell total number 19000 / cubic millimeter, neutrophil 83%, thin yellow fur, pulse fine number.

[0109] After taking the Chinese medicine composition of the present application for 6 days, the body heat was completely subsided, the cough and sputum were much, the sputum was blood and pus, but the odor was reduced, it was easy to cough out, the chest tightness was not painful, the chest X-ray showed that the right upper lung abscess was absorbed compared with before, the blood test showed that the white blood cell total number was 14700 / cubic millimeter, the neutrophil was 75%, after taking for 20 days, the cough was reduced, the sputum was sticky and bloody, the chest tightness was also eliminated, and the spirit was good.

[0110] While the experiment of example 1 was carried out, the same experiment was also carried out on other examples, and the same or similar results were obtained, which will not be listed one by one here, and no adverse reactions were found in the experiment, indicating that the drug is safe.

[0111] 7、Conclusion

[0112] In conclusion, the medicinal composition of the present application is combined according to the primary and secondary relationship of monarch, minister and assistant, and the prescription is scientific and reasonable. Rehmannia glutinosa, Houttuynia cordata, Scutellaria baicalensis and Panax ginseng are all fresh products, and the cold and cool properties are enhanced. Houttuynia cordata, Rehmannia glutinosa and Scutellaria baicalensis have stronger heat-clearing and detoxifying and abscess-dissolving and pus-discharging effects, and fresh Panax ginseng tonifies qi and benefits the lung, supports healthy qi and eliminates pathogenic factors. Gecko disperses and unblocks collaterals. The combination of the drugs achieves the effects of clearing the lung and resolving toxins, removing blood stasis and abscesses, supporting healthy qi and eliminating pathogenic factors, and dispersing and unblocking collaterals, and is effective in treating lung abscess and improving the quality of life, with an effective rate of 96% and a significant effect rate of 76%, which is much higher than 44% of the control group, and the effect is unexpected. Meanwhile, the traditional Chinese medicine composition of the present application forms a stable preparation process of fresh medicine, and the effective components of each raw medicinal material can be fully released after broken wall crushing, and the resources of medicinal materials are saved. The traditional Chinese medicine composition has the effect of treating lung abscess, and the curative effect is significantly improved, has no toxic side effects, and can be made into a pharmaceutically acceptable dosage form according to actual needs, has strong practical application value, is beneficial to industrialized production and development and popularization and application, and has huge economic and social benefits.

Claims

1. A method for preparing a traditional Chinese medicine composition for treating lung abscess, characterized in that: The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 3-10 parts of fresh Rehmannia root, 3-10 parts of fresh Houttuynia cordata, 3-7 parts of fresh Scutellaria baicalensis, 3-10 parts of fresh ginseng and 0.1-0.5 parts of gecko, and the preparation method is: (1) The fresh Rehmannia root is selected and washed 1 to 3 times, cut into pieces or slices while fresh, and added with water 0.5 to 4 times the weight volume of the original drug, where the weight volume refers to the solid in kg and the liquid in L, and the wall is broken for 1 to 10 minutes, filtered, and the filtrate is centrifuged at 2000 to 8000 r / min for 5 to 30 minutes to obtain the first supernatant; then water is added and the wall is broken and centrifuged 1 to 4 times according to the above method to obtain the second to fifth supernatants, and the supernatants of each time are combined; Fresh Houttuynia cordata is selected and washed 1-3 times, then cut into segments while still fresh, and the cells are broken with 1-5 times the volume of the original herb by weight. The cells are filtered and the filtrate is centrifuged at 2000-8000 rpm for 5-30 minutes to obtain the first supernatant. Water is then added and the cells are broken and centrifuged again 1-4 times as described above to obtain the second to fifth supernatants, which are then combined. Fresh Scutellaria baicalensis is selected and washed 1-3 times. Cut into sections or slices while fresh, add 1-5 times the weight and volume of water of the original herb, break the cell wall for 1-20 minutes, filter, and centrifuge the filtrate at 2000-8000 rpm for 5-30 minutes to obtain the first supernatant; then add water and repeat the above method of breaking the cell wall and centrifuging 1-4 times to obtain the second to fifth supernatants, and combine the supernatants from each time. Fresh ginseng is selected and washed 1-3 times. Cut into sections or slices while fresh, add 0.5-4 times the weight and volume of water of the original ginseng, break the ginseng wall for 1-20 minutes, filter, and centrifuge the filtrate at 2000-8000 rpm for 5-30 minutes to obtain the first supernatant; then add water and repeat the above method of breaking the wall and centrifuging 1-4 times to obtain the second to fifth supernatants, and combine the supernatants from each time; (2) The supernatants of the fresh Rehmannia root, Houttuynia cordata, fresh Scutellaria baicalensis and fresh ginseng were ultrafiltered using a 10000D ultrafiltration membrane to remove macromolecular substances, and the ultrafiltration permeates were collected and then concentrated using a 200D nanofiltration membrane to obtain nanofiltration concentrates; the nanofiltration concentrates were then freeze-dried, and the freeze-dried products were collected and pulverized to obtain freeze-dried powders; (3) Wash and cut the gecko medicinal material into sections, freeze-dry, grind into coarse powder, pass through an 80-100 mesh sieve, and then ultrafine grind and pass through a 100-300 mesh sieve to obtain gecko ultrafine powder; (4) The freeze-dried powders obtained in step (2) and the gecko ultrafine powder obtained in step (3) are uniformly mixed, vacuum-packed, and sterilized to obtain a finished product of the traditional Chinese medicine composition for treating lung abscess.

2. The method for preparing the Chinese medicine composition for treating lung abscess according to claim 1, wherein: The Chinese medicine composition is prepared from the following raw materials in parts by weight: 5 parts of fresh Rehmannia root, 7 parts of fresh Houttuynia cordata, 5 parts of fresh Scutellaria baicalensis, 7 parts of fresh ginseng and 0.5 parts of Gekko. The preparation method is as follows: (1) The fresh Rehmannia root was selected and washed twice, cut into pieces or 2-4 mm thick slices while fresh, added with 1 times the weight volume of the original drug, broken for 2.5 minutes, filtered, and the filtrate was centrifuged at 4000 r / min for 20 minutes to obtain the first supernatant; then 3 times the weight of water was added and the wall was broken and centrifuged twice according to the above method to obtain the second and third supernatants, and the supernatants of each time were combined; Fresh Houttuynia cordata was selected and washed twice, cut into segments while still fresh, and the cell walls were broken with water twice the weight of the original herb for 5 minutes. The filtrate was filtered and centrifuged at 4000 rpm for 20 minutes to obtain the first supernatant. Then, 4 times the weight of water was added and the cell walls were broken and centrifuged twice again according to the above method to obtain the second and third supernatants, and the supernatants from each were combined. Fresh Scutellaria baicalensis was selected and washed twice. Cut into segments or 2-4 mm thick slices while still fresh, add twice the volume of water by weight of the original drug, break the wall for 8 minutes, filter, and centrifuge the filtrate at 4000 rpm for 20 minutes to obtain the first supernatant. Then add 4 times the volume of water and repeat the above method for breaking the wall and centrifuging twice to obtain the second and third supernatants. Combine the supernatants from each time. Fresh ginseng is selected and washed twice. Cut into segments or 2-4 mm thick slices while fresh, add 1 times the volume of water by weight of the original ginseng, break the cell wall for 8 minutes, filter, and centrifuge the filtrate at 4000 rpm for 20 minutes to obtain the first supernatant. Then add 3 times the volume of water and repeat the above method for breaking the cell wall and centrifuging twice to obtain the second and third supernatants. Combine the supernatants from each time. (2) The supernatants of the fresh Rehmannia root, Houttuynia cordata, fresh Scutellaria baicalensis and fresh ginseng were ultrafiltered using a 10000D ultrafiltration membrane to remove macromolecular substances, and the ultrafiltration permeates were collected and then concentrated using a 200D nanofiltration membrane to obtain nanofiltration concentrates; the nanofiltration concentrates were then freeze-dried, and the freeze-dried products were collected and pulverized to obtain freeze-dried powders; (3) Wash and cut the gecko medicinal material into sections, freeze-dry, grind into coarse powder, pass through a 100-mesh sieve, and then ultrafine grind and pass through a 300-mesh sieve to obtain gecko ultrafine powder; (4) The freeze-dried powders obtained in step (2) and the gecko ultrafine powder obtained in step (3) are uniformly mixed, vacuum-packed, and sterilized to obtain a traditional Chinese medicine composition for treating lung abscess.

3. The method for preparing the Chinese medicine composition for treating lung abscess according to claim 1, wherein: The Chinese medicine composition is prepared from the following raw materials in parts by weight: 7 parts of fresh Rehmannia root, 7 parts of fresh Houttuynia cordata, 7 parts of fresh Scutellaria baicalensis, 10 parts of fresh ginseng and 0.3 parts of gecko, and the preparation method is as follows: (1) The fresh Rehmannia root was selected and washed twice, cut into pieces while fresh, added with water 3 times the weight and volume of the original drug, broken for 5 minutes, filtered, and the filtrate was centrifuged at 6000 r / min for 15 minutes to obtain the first supernatant; then water was added and the cell wall was broken and centrifuged again according to the above method to obtain the second supernatant, and the supernatants were combined; Fresh Houttuynia cordata was selected and washed twice, cut into segments while still fresh, and added with water 4 times the weight and volume of the original herb, and the cell walls were broken for 5 minutes. The filtrate was filtered and centrifuged at 6000 rpm for 15 minutes to obtain the first supernatant. Water was then added and the cell walls were broken and centrifuged again as described above to obtain the second supernatant. The supernatants from each supernatant were combined. Fresh Scutellaria baicalensis was selected and washed twice, cut into segments while still fresh, and added with water 4 times the weight and volume of the original drug, and the cell wall was broken for 10 minutes, filtered, and the filtrate was centrifuged at 6000 rpm for 15 minutes to obtain the first supernatant; then water was added and the cell wall was broken and centrifuged again according to the above method to obtain the second supernatant, and the supernatants from each were combined; Fresh ginseng was selected and washed twice, cut into segments while still fresh, and the cells were broken with water 3 times the volume of the original drug weight for 10 minutes. The filtrate was filtered and centrifuged at 6000 rpm for 15 minutes to obtain the first supernatant. Water was then added and the cells were broken and centrifuged again as described above to obtain the second supernatant. The supernatants from each supernatant were combined. (2) The supernatants of the fresh Rehmannia root, Houttuynia cordata, fresh Scutellaria baicalensis and fresh ginseng were ultrafiltered using a 10000D ultrafiltration membrane to remove macromolecular substances, and the ultrafiltration permeates were collected and then concentrated using a 200D nanofiltration membrane to obtain nanofiltration concentrates; the nanofiltration concentrates were then freeze-dried, and the freeze-dried products were collected and pulverized to obtain freeze-dried powders; (3) Wash and cut the gecko medicinal material into sections, freeze-dry, grind into coarse powder, pass through a 100-mesh sieve, and then ultrafine grind and pass through a 220-mesh sieve to obtain gecko ultrafine powder; (4) The freeze-dried powders obtained in step (2) and the gecko ultrafine powder obtained in step (3) are uniformly mixed, vacuum-packed, and sterilized to obtain a finished product of the traditional Chinese medicine composition for treating lung abscess.

4. The method for preparing the Chinese medicine composition for treating lung abscess according to claim 1, wherein: The Chinese medicine composition is prepared from the following raw materials in parts by weight: 10 parts of fresh Rehmannia root, 10 parts of fresh Houttuynia cordata, 7 parts of fresh Scutellaria baicalensis, 10 parts of fresh ginseng and 0.5 parts of Gekko. The preparation method is as follows: (1) The fresh Rehmannia root was selected and washed once, and then cut into 2-4 mm thick slices while fresh, and water 4 times the weight volume of the original drug was added, and the cell wall was broken for 10 minutes, and the filtrate was filtered. The filtrate was centrifuged at 6000 r / min for 30 minutes to obtain the supernatant; Fresh Houttuynia cordata was selected and washed once, cut into segments while fresh, and added with water 5 times the weight and volume of the original herb, and the cell wall was broken for 10 minutes, filtered, and the filtrate was centrifuged at 6000 r / min for 30 minutes to obtain the supernatant; Fresh Scutellaria baicalensis was selected and washed once, then cut into 2-4 mm thick slices while fresh, and added with water 5 times the weight and volume of the original drug, and the slices were broken for 20 minutes. The filtrate was filtered and centrifuged at 6000 rpm for 30 minutes to obtain the supernatant. Fresh ginseng was selected and washed once, then cut into 2-4 mm thick slices while fresh, and the slices were broken with water 4 times the weight of the original ginseng. The slices were filtered for 20 minutes, and the filtrate was centrifuged at 6000 rpm for 30 minutes to obtain the supernatant. (2) The supernatants of the fresh Rehmannia root, Houttuynia cordata, fresh Scutellaria baicalensis and fresh ginseng were ultrafiltered using a 10000D ultrafiltration membrane to remove macromolecular substances, and the ultrafiltration permeates were collected and then concentrated using a 200D nanofiltration membrane to obtain nanofiltration concentrates; the nanofiltration concentrates were then freeze-dried, and the freeze-dried products were collected and pulverized to obtain freeze-dried powders; (3) Wash and cut the gecko medicinal material into sections, freeze-dry, grind into coarse powder, pass through an 80-mesh sieve, and then ultrafine grind and pass through a 100-mesh sieve to obtain gecko ultrafine powder; (4) The freeze-dried powders obtained in step (2) and the gecko ultrafine powder obtained in step (3) are uniformly mixed, vacuum-packed, and sterilized to obtain a finished product of the traditional Chinese medicine composition for treating lung abscess.

5. The method for preparing the Chinese medicine composition for treating lung abscess according to claim 1, wherein: The Chinese medicine composition is prepared from the following raw materials in parts by weight: 3 parts of fresh Rehmannia root, 5 parts of fresh Houttuynia cordata, 3 parts of fresh Scutellaria baicalensis, 5 parts of fresh ginseng and 0.1 part of Gekko. The preparation method is as follows: (1) The fresh Rehmannia root was selected and washed twice, cut into segments while fresh, added with water 0.5 times the weight volume of the original drug, broken for 5 minutes, filtered, and the filtrate was centrifuged at 2000 r / min for 30 minutes to obtain the first supernatant; then added with water 3 times the weight volume of the original drug, broken for 2.5 minutes, filtered, and the filtrate was centrifuged at 4000 r / min for 15 minutes to obtain the second supernatant, and then added with water and repeated the wall breaking and centrifugation twice according to the above method to obtain the third and fourth supernatants, and the supernatants of each time were combined; After selecting, wash Houttuynia cordata twice, cut into segments while fresh, add 1 times the weight volume of water of the original drug, break the cell wall for 5 minutes, filter, and centrifuge the filtrate at 2000 r / min for 30 minutes to obtain the first supernatant; then add 3 times the weight volume of water of the original drug, break the cell wall for 2.5 minutes, filter, and centrifuge the filtrate at 4000 r / min for 15 minutes to obtain the second supernatant. Repeat the above method of adding water and breaking the cell wall and centrifuging twice to obtain the third and fourth supernatants, and combine the supernatants from each time; Fresh Scutellaria baicalensis was selected and washed 1-3 times. The fresh Scutellaria baicalensis was cut into sections or slices, and water (1 times the weight and volume of the original drug) was added, the cell walls were broken for 10 minutes, filtered, and the filtrate was centrifuged at 2000 r / min for 30 minutes to obtain the first supernatant. Then, water (3 times the weight and volume of the original drug) was added, the cell walls were broken for 5 minutes, filtered, and the filtrate was centrifuged at 4000 r / min for 15 minutes to obtain the second supernatant. Water was added again and the cell walls were broken and centrifuged twice more to obtain the third and fourth supernatants. The supernatants from each time were combined. After selecting, fresh ginseng is washed 1-3 times, cut into sections or slices while fresh, add 0.5 times the weight volume of the original ginseng, break the cell wall for 10 minutes, filter, and centrifuge the filtrate at 2000 r / min for 30 minutes to obtain the first supernatant; then add 3 times the weight volume of the original ginseng, break the cell wall for 5 minutes, filter, and centrifuge the filtrate at 4000 r / min for 15 minutes to obtain the second supernatant, then add water and repeat the above method for breaking the cell wall and centrifuging twice to obtain the third and fourth supernatants, and combine the supernatants from each time; (2) The supernatants of the fresh Rehmannia root, Houttuynia cordata, fresh Scutellaria baicalensis and fresh ginseng were ultrafiltered using a 10000D ultrafiltration membrane to remove macromolecular substances, and the ultrafiltration permeates were collected and then concentrated using a 200D nanofiltration membrane to obtain nanofiltration concentrates; the nanofiltration concentrates were then freeze-dried, and the freeze-dried products were collected and pulverized to obtain freeze-dried powders; (3) Wash and cut the gecko medicinal material into sections, freeze-dry, grind into coarse powder, pass through a 100-mesh sieve, and then ultrafine grind and pass through a 280-mesh sieve to obtain gecko ultrafine powder; (4) The freeze-dried powders obtained in step (2) and the gecko ultrafine powder obtained in step (3) are uniformly mixed, vacuum-packed, and sterilized to obtain a finished product of the traditional Chinese medicine composition for treating lung abscess.

6. The method for preparing the Chinese medicine composition for treating lung abscess according to claim 1, wherein: The Chinese medicine composition is prepared from the following raw materials in parts by weight: 9 parts of fresh Rehmannia root, 3 parts of fresh Houttuynia cordata, 6 parts of fresh Scutellaria baicalensis, 3 parts of fresh ginseng and 0.2 parts of Gekko. The preparation method is as follows: (1) The fresh Rehmannia root was selected and washed three times, cut into pieces while fresh, added with water twice the weight volume of the original drug, broken for 5 minutes, filtered, and the filtrate was centrifuged at 8000 r / min for 5 minutes to obtain the first supernatant; then water was added and the cell wall was broken and centrifuged again according to the above method for 4 times to obtain the second to fifth supernatants, and the supernatants of each time were combined; Fresh Houttuynia cordata was selected and washed three times, cut into segments while still fresh, and added with water twice the weight and volume of the original herb, and the cell walls were broken for 3 minutes. The filtrate was filtered and centrifuged at 8000 rpm for 5 minutes to obtain the first supernatant. Water was then added and the cell walls were broken and centrifuged again four times according to the above method to obtain the second to fifth supernatants, and the supernatants from each were combined. Fresh Scutellaria baicalensis was selected and washed three times. Cut into segments while still fresh, add twice the volume of water by weight of the original drug, break the wall for 10 minutes, filter, and centrifuge the filtrate at 8000 rpm for 5 minutes to obtain the first supernatant. Then add water and repeat the above method of breaking the wall and centrifuging four times to obtain the second to fifth supernatants, and combine the supernatants from each time. Fresh ginseng was selected and washed three times, then cut into segments while still fresh, and the cells were broken with water twice the volume of the original ginseng by weight for 8 minutes. The filtrate was filtered and centrifuged at 8000 rpm for 5 minutes to obtain the first supernatant. Water was then added and the cell wall was broken and centrifuged four times as described above to obtain the second to fifth supernatants, which were then combined. (2) The supernatants of the fresh Rehmannia root, Houttuynia cordata, fresh Scutellaria baicalensis and fresh ginseng were ultrafiltered using a 10000D ultrafiltration membrane to remove macromolecular substances, and the ultrafiltration permeates were collected and then concentrated using a 200D nanofiltration membrane to obtain nanofiltration concentrates; the nanofiltration concentrates were then freeze-dried, and the freeze-dried products were collected and pulverized to obtain freeze-dried powders; (3) Wash and cut the gecko medicinal material into sections, freeze-dry, grind into coarse powder, pass through an 80-mesh sieve, and then ultrafine grind and pass through a 180-mesh sieve to obtain gecko ultrafine powder; (4) The freeze-dried powders obtained in step (2) and the gecko ultrafine powder obtained in step (3) are uniformly mixed, vacuum-packed, and sterilized to obtain a finished product of the traditional Chinese medicine composition for treating lung abscess.

7. Use of the traditional Chinese medicine composition for treating lung abscess prepared by the method according to any one of claims 1 to 6 in preparing medicine for treating lung abscess.

8. Use of the traditional Chinese medicine composition for treating lung abscess prepared by the method according to claim 7 in preparing medicine for treating lung abscess, characterized in that: The traditional Chinese medicine composition for treating lung abscess is further added with pharmaceutically acceptable adjuvants to prepare granules, tablets or capsules.

9. Use of the traditional Chinese medicine composition for treating lung abscess prepared by the method according to any one of claims 1 to 6 in preparing medicines for preventing and alleviating lung abscess.

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