Traditional Chinese medicine compound for treating spleen deficiency and excessive dampness type obesity of children

Abstract

The invention discloses a traditional Chinese medicine compound for treating spleen deficiency and excessive dampness type obesity of children. The traditional Chinese medicine compound is prepared from, by weight, 12-15 parts of poria cocos, 9-10 parts of cassia twigs, 6-10 parts of rhizoma atractylodis macrocephalae, 6-10 parts of honey-fried licorice roots, 6-8 parts of rhizoma alismatis, 9-10 parts of hawthorn fruits, 6-8 parts of pericarpium citri reticulatae and 9-12 parts of codonopsis pilosula. According to the traditional Chinese medicine compound for treating the spleen deficiency and excessive dampness type obesity of children, all the medicines coordinate with one another, and the effect of effectively treating the spleen deficiency and excessive dampness type obesity can be achieved.

Description

TECHNICAL FIELD

[0001] The present application relates to a kind of traditional Chinese medicine compound for treating children with spleen deficiency and dampness obesity. BACKGROUND

[0002] Obesity refers to a nutritional disorder caused by multiple factors, which leads to excessive accumulation of fat in the body and weight exceeding the reference value range. Obesity affects various systems of children and adolescents, not only causing harm to physical activity, skeletal muscle development and cognitive development, but also having adverse effects on their mental health, cardiovascular system, endocrine system, respiratory system, etc. Obesity and its related metabolic diseases, such as diabetes, non-alcoholic fatty liver disease, metabolic syndrome, and precocious puberty, seriously threaten children's health. In addition, obesity is likely to persist into adulthood, causing long-term disease burden for adults. Therefore, strengthening the monitoring and prevention of childhood obesity is crucial for improving the health of the nation.

[0003] Western medicine treatment methods for childhood obesity include lifestyle and psychological behavior intervention, drugs and weight loss surgery. Only after formal intensive lifestyle intervention, the body weight increase or complications have not been controlled, or there is a contraindication to exercise, can drug treatment be performed on obese children.

[0004] Obesity belongs to the category of "fatty" and "phlegm-damp" in traditional Chinese medicine, and is caused by abnormal water metabolism. The pathological attribute is deficiency in the root and excess in the branch, with qi deficiency and yang deficiency in the root and phlegm and dampness in the branch. "Fatty and rich people are high in millet disease," according to "Discussion on Deficiency and Excess" in "Plain Questions." Zhu Danxi first proposed "fatty and white people have phlegm and dampness" in Yuan Dynasty. Zhang Zhongjing believed that if the yang is deficient and the spleen is not healthy, the gasification is not beneficial, and the water and dampness are stopped inside, causing phlegm and fluid, so he proposed the disease name "phlegm and fluid" in the book "Synopsis of Golden Chamber", and established the treatment principle of "phlegm and fluid should be treated with warm medicine", and created Linggui Zhugan Decoction to treat phlegm and fluid.

[0005] In view of the view of "fatty and white people have phlegm and dampness", traditional Chinese medicine treats obesity from the perspective of phlegm and dampness. There are many such traditional Chinese medicine compositions for treating obesity, but most of them are for adults, for example, expensive; The efficacy is not obvious; The taste is not good, and it is difficult for children to take, etc. SUMMARY

[0006] The main purpose of the present application is to provide a traditional Chinese medicine compound for treating children with spleen deficiency and dampness obesity.

[0007] The technical solution adopted by the present application to solve its technical problems is:

[0008] A traditional Chinese medicine composition for treating children obesity of spleen deficiency and dampness excess type, which comprises the following raw medicinal materials in parts by weight: 12-15 parts of poria, 9-10 parts of cassia twig, 6-10 parts of white atractylodes, 6-10 parts of fried licorice, 6-8 parts of alisma, 9-10 parts of hawthorn, 6-8 parts of dried tangerine or orange peel, and 9-12 parts of codonopsis.

[0009] Since the creation of the Lingui Zhigan Decoction, it has been used as a representative and basic prescription for warming and resolving phlegm and fluid retention, and has been widely used by later generations of physicians. The present prescription enhances the functions of dampness elimination and fat reduction and increases the effect of qi nourishment on the basis of the Lingui Zhigan Decoction according to the clinical manifestations of children obesity of spleen deficiency and dampness excess type, and provides a traditional Chinese medicine composition with high operability, compliance, safety and effectiveness for children obesity.

[0010] Further, the traditional Chinese medicine compound is equivalent to 63-83 g of raw medicinal materials per 1 dose of the traditional Chinese medicine compound.

[0011] In a preferred embodiment, the traditional Chinese medicine composition comprises the following raw medicinal materials in parts by weight: 12 parts of poria, 9 parts of cassia twig, 6 parts of white atractylodes, 6 parts of fried licorice, 6 parts of alisma, 9 parts of hawthorn, 6 parts of dried tangerine or orange peel, and 9 parts of codonopsis.

[0012] Further, the traditional Chinese medicine compound is prepared by the following method: taking raw medicinal materials according to the mass fraction ratio, then adding water 10-20 times the weight of the raw medicinal materials, decocting 2-4 times, each time for 30-40 min, combining the decocting liquid, filtering the residue, and concentrating the filtrate to a medicinal liquid with a crude drug content of 1.8-2.2 g / mL. The obtained medicine can be stored in a 4℃ refrigerator and used after heating in a 37℃ water bath before intragastrical administration.

[0013] The present application also provides the use of the traditional Chinese medicine composition in the preparation of a medicament for treating children obesity of spleen deficiency and dampness excess type.

[0014] The obtained medicinal liquid can be used to prepare a preparation. The dosage form of the preparation includes tablets, pills, pastes, powders, oral liquids, granules or capsules.

[0015] In the present application, the pharmacology and efficacy of each raw medicinal material are as follows:

[0016] Poria: first appeared in Shennong's Herbal Classic, sweet and mild in taste, and flat in nature, and belongs to the lung, spleen, heart and kidney channels, and has the effects of promoting water metabolism, strengthening the spleen, stopping diarrhea, nourishing the heart and calming the nerves, and the effect of strengthening the spleen and eliminating dampness. It is used for treating dysuria, edema, spleen deficiency diarrhea, leukorrhea, phlegm and cough, dampness into the collaterals, shoulder and back pain, palpitation and insomnia.

[0017] Cassia twig: first appeared in Tang Bencao, sweet and bitter in taste, and warm in nature, and belongs to the bladder, heart and lung channels, and has the effects of sweating and relieving the exterior, warming and unblocking meridians, and warming yang and transforming qi. It is used for treating wind-cold syndrome, cold and blood stasis pain, abdominal cold pain, amenorrhea and dysmenorrhea, joint pain, phlegm and edema, palpitation and dizziness.

[0018] Atractylodes: First recorded in Shennong's Herbal, sweet and mild in taste, neutral in nature, it belongs to the lung, spleen, heart and kidney channels, and has the effects of promoting water metabolism, strengthening the spleen, stopping diarrhea, nourishing the heart and calming the nerves. Its main functions are to strengthen the spleen and expel dampness. It is used to treat spleen deficiency, abdominal distension, diarrhea, dizziness, edema, sweating, and fetal movement.

[0019] Radix Glycyrrhizae: Licorice is known as the "national old" in traditional Chinese medicine, and is also known as the "king of Chinese medicine". Licorice is sweet in taste, neutral in nature, and belongs to the spleen, stomach, heart and lung channels. It can tonify the spleen and replenish qi, expel phlegm and relieve cough, relieve pain and harmonize the effects of various drugs. It is used to treat spleen and stomach weakness, palpitations, chest tightness, pulse knotting, various types of cough (wind-cold, wind-heat, dry lung, etc.), especially for yin deficiency and lung dryness (little sticky sputum), abdominal pain, and pain in the limbs. It can also relieve drug toxicity and intensity, and coordinate drug effects.

[0020] Alisma: First recorded in Shennong's Herbal, sweet and mild in taste, cold in nature, it mainly belongs to the bladder and kidney channels, and has the effects of reducing turbidity and lowering lipid, promoting water metabolism and reducing dampness. It is used to treat hyperlipidemia, edema, heat stranguria, diabetes, phlegm, and yellow and thick leukorrhea.

[0021] Hawthorn: Hawthorn was first recorded in Tang Dynasty's New Revised Herbal, and was originally named "red claw grass". Later, it was named hawthorn in the Supplement to the Expanded Interpretation of Materia Medica. Hawthorn is sour and sweet in taste, slightly warm in nature, and mainly belongs to the liver, spleen and stomach channels. It has the effects of digesting food and resolving accumulation, dispersing blood stasis, reducing turbidity and lowering lipid. It is used to treat abdominal distension, food accumulation, acid regurgitation, diarrhea, abdominal pain, chest pain, and hyperlipidemia.

[0022] Dried Orange Peel: First recorded in Shennong's Herbal, dried orange peel (then known as "orange") was first listed as a top-grade wood. It is pungent, bitter and warm in nature, and mainly belongs to the spleen and stomach channels. It can regulate qi, invigorate the spleen, dry dampness, reduce phlegm and resolve masses. It is used to treat spleen and stomach qi stagnation and phlegm-dampness.

[0023] Codonopsis: First recorded in New Herbal, it is neutral in nature, sweet and slightly sour in taste. It belongs to the spleen and lung channels. It can tonify the center, replenish qi, invigorate the spleen and lung, nourish blood and generate fluid. It is used to treat spleen and lung qi deficiency, blood and fluid deficiency, and thirst.

[0024] The application is composed of Poria cocos, cassia twig, atractylodes, licorice, alisma, hawthorn, tangerine peel, and radix codonopsis. Poria cocos is the monarch drug in the prescription, which is sweet and bitter, and can eliminate the phlegm and water in the body and strengthen the spleen. Cassia twig can warm the yang and transform the qi, and the combination of Poria cocos and cassia twig can enhance the function of transforming the dampness. Atractylodes can strengthen the spleen and dry the dampness, and is used with Poria cocos to enhance the function of cultivating the earth and regulating the water. Licorice and cassia twig can strengthen the yang and the function of benefiting the qi, and atractylodes can increase the function of benefiting the qi and strengthening the spleen. Tangerine peel can regulate the qi and the function of the spleen and stomach, and alisma can eliminate the dampness and reduce the fat. The whole prescription can strengthen the spleen and eliminate the dampness, and can eliminate the phlegm and transform the qi.

[0025] The compound medicine of traditional Chinese medicine for treating children obesity caused by spleen deficiency and dampness accumulation is selected from 8 natural traditional Chinese medicines (Poria cocos, cassia twig, atractylodes, licorice, alisma, hawthorn, tangerine peel, and radix codonopsis). The medicines in the prescription, such as atractylodes, Poria cocos, and radix codonopsis, have the functions of strengthening the spleen and benefiting the qi, and can enhance the function of the spleen and stomach, promote the metabolism and discharge of the dampness, eliminate the dampness and phlegm, reduce the accumulation of the phlegm and dampness in the body, improve the constitution of spleen deficiency and dampness, accelerate the combustion and decomposition of the fat in the body, and improve the obesity caused by endocrine disorder. The prescription is simple, and has the functions of treating the symptoms and the root cause. The preparation method is simple, and the medicine is convenient to take and low in cost. The prescription of Poria cocos, cassia twig, atractylodes, and licorice can only treat the symptoms, and the prescription of the application can treat the symptoms and the root cause, and is more suitable for the core pathogenesis of spleen deficiency and dampness accumulation. The obesity of children is caused by overeating, and the long-term accumulation of the fat in the body can cause qi stagnation and blood stasis. The prescription of the application can eliminate the dampness and phlegm, and treat the qi stagnation and blood stasis. The early abnormality of the sugar and fat metabolism of children can be treated by the prescription of the application. The spleen of children is often deficient, and the prescription of the application can protect the qi of the spleen and stomach, and the hawthorn can eliminate the meat and improve the taste, and the children can take the medicine. BRIEF DESCRIPTION OF DRAWINGS

[0026] The application will be further described in combination with the drawings and examples.

[0027] Figure 1 The liver tissue of each group of mice was compared.

[0028] Figure 2 The contents of TC, LDL-C, HDL-C, GLU, and RI obesity index in the serum of each group of mice were compared.

[0029] Figure 3For each group of mice, the serum TNF-α, IL-1β and IL-6 inflammatory markers were detected by Elisa.

[0030] Figure 4 For RT-PCR detection of the expression of TNF-α, IL-6 and PPARγ in the liver tissue of mice.

[0031] Figure 5 For RT-PCR detection of the expression of TNF-α, IL-6 and PPARγ in the liver tissue of mice. DETAILED DESCRIPTION

[0032] Example 1

[0033] Poria cocos 12 parts, cassia bark 9 parts, white atractylodes 6 parts, prepared licorice 6 parts, alisma 6 parts, hawthorn 9 parts, dried tangerine or orange peel 6 parts, and codonopsis 9 parts.

[0034] The traditional Chinese medicine compound is prepared by the following method: taking raw medicinal materials according to the mass fraction ratio, then adding 20 times the weight of water to decoct the raw medicinal materials for 3 times, each time for 35 min, combining the decocting liquid, filtering the residue, and concentrating the filtrate to a medicinal liquid with a crude drug content of 2 g / mL. The obtained medicine is stored in a 4°C refrigerator and used after heating in a 37°C water bath before gavage.

[0035] Example 2

[0036] Poria cocos 14 parts, cassia bark 9 parts, white atractylodes 10 parts, prepared licorice 8 parts, alisma 8 parts, hawthorn 9 parts, dried tangerine or orange peel 7 parts, and codonopsis 10 parts.

[0037] The traditional Chinese medicine compound is prepared by the following method: taking raw medicinal materials according to the mass fraction ratio, then adding 20 times the weight of water to decoct the raw medicinal materials for 3 times, each time for 35 min, combining the decocting liquid, filtering the residue, and concentrating the filtrate to a medicinal liquid with a crude drug content of 2 g / mL. The obtained medicine is stored in a 4°C refrigerator and used after heating in a 37°C water bath before gavage.

[0038] Example 3

[0039] Poria cocos 15 parts, cassia bark 10 parts, white atractylodes 8 parts, prepared licorice 10 parts, alisma 7 parts, hawthorn 10 parts, dried tangerine or orange peel 8 parts, and codonopsis 12 parts.

[0040] The traditional Chinese medicine compound is prepared by the following method: taking raw medicinal materials according to the mass fraction ratio, then adding 20 times the weight of water to decoct the raw medicinal materials for 3 times, each time for 35 min, combining the decocting liquid, filtering the residue, and concentrating the filtrate to a medicinal liquid with a crude drug content of 2 g / mL. The obtained medicine is stored in a 4°C refrigerator and used after heating in a 37°C water bath before gavage.

[0041] The traditional Chinese medicine compound of the present application for treating children with spleen deficiency and dampness obesity, each drug can achieve the effect of treating spleen deficiency and dampness obesity, and the drugs are indispensable. The experimental results are provided below:

[0042] I. Research method

[0043] 1. Model preparation: adopt "high-fat diet feeding" to replicate the obese mouse model (high-fat diet contains 20% carbohydrates, 20% protein and 60% fat).

[0044] 2. Animal grouping and drug administration

[0045] The mice were randomly divided into 3 groups (8 mice in each group): normal group, modeling group, and traditional Chinese medicine compound treatment group (prepared in Example 1). The drug groups were given traditional Chinese medicine by gavage for 2 weeks, and then the mice were treated and the samples were collected. The dosages of the drugs were 10 times the amount of 60 kg adult equivalent weight, and the gavage volume was 10 mL / kg mouse weight. The normal group and the model group were given distilled water by gavage.

[0046] 3. Main observation content and method

[0047] HE staining (hematoxylin-eosin) was used to observe the pathological changes of mouse liver tissue, and the enzyme marker (CMax Plus Meigu Molecular Instrument Co., Ltd.) was used to determine the contents of mouse serum TC, LDL-C, HDL-C, GLU and RI. ELISA was used to detect the levels of TNF-α, IL-1β and IL-6 in mouse serum. RT-PCR was used to detect the expression changes of TNF-α, IL-6 and PPARγ mRNA in mouse liver tissue.

[0048] Elisa

[0049] (1) Serum sample: after thawing, centrifuge the sample at 1000xg for 20 minutes, and take the supernatant for detection.

[0050] (2) Standard solution: centrifuge the GLU, RI, TNFα, IL-1β and IL-6 standards at 1000xg for 5 min, and the different concentrations of standards are shown in the table below.

[0051] Table 5: Dilution concentrations of 5 Elisa kit standard curves

[0052]

[0053] (3) Sample addition: take 100 μL of different concentrations of standards and add them to the standard wells, and take another 100 μL of serum sample to be tested and add it to other wells. Add the sample to the bottom of the enzyme-labeled plate well, and mix gently.

[0054] (4) Add enzyme: add 100 μL of biotinylated antibody working solution to each well, mix, seal with sealing film, and incubate in a 37°C oven for 60 min.

[0055] (5) Add enzyme: discard the liquid, spin dry, add 100 μL of biotinylated antibody working solution to each well, mix, seal with sealing film, and incubate in a 37°C oven for 60 min.

[0056] (6) Wash: spin off the liquid in the wells, add 350 μL of washing solution to each well, soak for 1 min, and aspirate or spin off the liquid in the enzyme-labeled plate. Dry with thick absorbent paper, and repeat the plate washing step 5 times.

[0057] (7) Add enzyme conjugate working solution: add 100 μL of enzyme conjugate working solution to each well, seal with sealing film, and incubate in a 37°C oven for 30 min.

[0058] (8) Wash: discard the liquid in the wells, spin dry, and wash the plate 5 times according to step 6.

[0059] (9) Color development: add 90 μL of substrate solution (TMB) to each well, seal with sealing film, and incubate in a 37°C oven for 15 min

[0060] (10) Termination: add 50 μL of termination solution to each well to terminate the reaction.

[0061] (11) Measurement: measure the absorbance (OD value) of each well at a wavelength of 450 nm.

[0062] Calculation: calculate the content of each index in the serum according to the standard curve.

[0063] HE staining

[0064] The routine method is used.

[0065] 2. RT-PCR

[0066] (1) Design 4 pairs of RT-PCR primers: TNF-a, IL-6, PPARγ, and β-actin PCR detection primer information table

[0067]

[0068] (2) RNA extraction: about 30 mg of liver tissue was weighed and ground with liquid nitrogen; 0.6 mL Trizol was added and lysed at room temperature for 5 min, centrifuged at 12000 rpm for 10 min at 4°C; the supernatant was taken, 0.2 mL chloroform was added to each 1 mL of lysate, shaken for 15 s, incubated at room temperature for 3 min, centrifuged at 12000 rpm for 10 min at 4°C, the sample was divided into three layers, the uppermost layer was taken, and the volume of the aqueous phase was recorded; add half the volume of ethanol to the aqueous phase, mix well and transfer to the adsorption column, centrifuge at 12000 rpm for 45 s; add 500 μL of deproteinization solution and centrifuge at 12000 rpm for 45 s, wash twice with 500 μL of rinse solution and centrifuge at 12000 rpm for 45 s; elute the RNA with 100 μL of water, and determine the RNA concentration with a micro-enzyme label meter.

[0069] (3) RNA reverse transcription: 1 μg of each sample was subjected to reverse transcription, and the reverse transcription system was prepared according to the following table.

[0070] Table 2: RNA reverse transcription system

[0071]

[0072] Note: RNA and H2O are added first, incubated in a 65°C water bath for 5 min, then add Primer mix, RT Enzyme mix and 5×RT buffer, mix well, incubate in a 37°C water bath for 15 min, and transfer to a 95°C water bath for 5 min.

[0073] (4) Preparation of RT-PCR system: the RT-PCR system was prepared according to the following table.

[0074] Table 3: RT-PCR amplification system

[0075]

[0076] Note: Prepare the large system first, then the small system, mix well, and take 10 μL into different qPCR wells, cover tightly, and centrifuge briefly.

[0077] (5) RT-PCR machine detection: amplification was performed according to the following table.

[0078] Table 4: RT-PCR amplification program

[0079]

[0080]

[0081] Agarose gel electrophoresis detection: 2 μL of each sample was taken and subjected to 1% agarose gel electrophoresis detection, electrophoresis for 10 min, and imaging on a gel imager.

[0082] II. Experimental Results

[0083] 1. Comparison of the pathological morphology of liver tissue in each group of mice

[0084] The liver lobule structure of the blank control group was clear, the size of the liver cells was uniform, the nucleus was clear, the cytoplasm was uniform, and no lipid droplets were produced. The liver cell morphology and structure of the model group were abnormal, the cell boundary was unclear, the liver cells were loosely connected in a round shape, the swelling was severe, the liver lobule structure was chaotic, and there were diffuse round white vacuole-shaped lipid droplets in the cytoplasm, indicating fatty degeneration. The liver lobule structure of the traditional Chinese medicine group was clear, the size of the liver cells was uniform, the nucleus was clear, the cytoplasm was uniform, and no lipid droplets were produced. Figure 1 .

[0085] 2. Comparison of the contents of serum TC, LDL-C, HDL-C, GLU and RI obesity indicators in each group of mice

[0086] Compared with the blank control group, the contents of TC, LDL-C, GLU and RI in the serum of the model group were significantly increased (P<0.05), and the content of HDL-C was significantly decreased (P<0.05). Compared with the model group, the content of TC in the traditional Chinese medicine group was significantly decreased (P<0.01), the contents of LDL-C, GLU and RI were decreased to a certain extent (P<0.05), and the content of HDL-C was increased to a certain extent (P<0.05). See Figure 2 , Table 1. These results show that after treatment, the contents of TC, LDL-C, HDL-C, GLU and RI in the treatment group of the traditional Chinese medicine compound are decreased. There is a significant statistical difference.

[0087] Table 1 Changes in the contents of serum TC, LDL-C, HDL-C, GLU and RI in each group of mice

[0088]

[0089]

[0090] 3. Comparison of the inflammatory indicators of TNF-α, IL-1β and IL-6 in the serum of each group of mice by Elisa

[0091] The contents of TNFα, IL-1β and IL-6 in the serum of the model group were significantly increased (p<0.001). Compared with the model group, the contents of TNFα and IL-1β in the traditional Chinese medicine group were significantly decreased (p<0.01), and the content of IL-6 was decreased to a certain extent (p<0.05). See Figure 3 , Table 2. These results show that after treatment, the contents of TNFα, IL-1β and IL-6 in the treatment group of the traditional Chinese medicine compound are decreased. There is a significant statistical difference.

[0092] Table 2 Elisa detection of TNF-α, IL-1β and IL-6 in mouse serum

[0093]

[0094] 4. Comparison of TNF-α, IL-6, and PPARγ mRNA expression in mouse liver tissue by RT-PCR

[0095] The results are as follows Figure 4 、 5 As shown in Table 3, compared with the blank control group, the expression of TNFα and IL-6 mRNA in liver tissue of the model group was significantly increased (p<0.01), and the expression of PPARγ mRNA was significantly decreased (p<0.001). Compared with the model group, the expression of TNFα and IL-6 mRNA in the Chinese medicine group decreased to a certain extent (p<0.05), and the expression of PPARγ mRNA was significantly increased (p<0.01).

[0096] Table 3 RT-PCR detection of TNF-α, IL-6 and PPARγ mRNA expression in mouse liver tissue

[0097]

[0098] Obesity is not only a metabolic disease but also a chronic, low-grade inflammatory disease, primarily due to an increase in the number and volume of fat tissues caused by the secretion of proinflammatory cytokines, macrophage infiltration, and impaired function of tissues involved in glucose homeostasis. Among the adipose cytokines, IL-1β, IL-6, and TNF-α have been shown to be involved in the inflammatory response during the development of obesity. Modulating these inflammatory cytokines can reduce inflammatory responses and slow the progression of the disease.

[0099] The above description is merely a preferred embodiment of the present invention and therefore cannot be used to limit the scope of the present invention. In other words, equivalent changes and modifications made according to the scope of the present invention and the contents of the specification should still fall within the scope of the present invention.

Claims

1. A Chinese medicine composition for treating obesity of spleen deficiency and dampness excess type in children, characterized in that: The invention comprises the following raw materials in parts by weight: 12-15 parts of Poria cocos, 9-10 parts of cinnamon twig, 6-10 parts of Atractylodes macrocephala, 6-10 parts of roasted licorice root, 6-8 parts of Alisma orientalis, 9-10 parts of hawthorn, 6-8 parts of dried tangerine peel and 9-12 parts of Codonopsis pilosula.

2. The Chinese medicine complex according to claim 1, characterized in that: Each dose of the traditional Chinese medicine complex is equivalent to 63 to 83 g of the raw medicine.

3. The Chinese medicine composition according to claim 1, characterized in that The invention comprises the following raw materials in parts by weight: 12 parts of Poria cocos, 9 parts of cinnamon twig, 6 parts of Atractylodes macrocephala, 6 parts of prepared licorice root, 6 parts of Alisma orientalis, 9 parts of hawthorn, 6 parts of dried tangerine peel and 9 parts of Codonopsis pilosula.

4. The Chinese medicine complex according to claim 1, characterized in that: The traditional Chinese medicine complex is prepared by the following method: taking the raw medicine according to the mass fraction ratio, adding water 10 to 20 times the weight of the raw medicine, and decocting 2 to 4 times, each time for 30 to 40 minutes, combining the decoctions, filtering to remove the residue, and concentrating the filtrate to a medicinal solution with a crude drug content of 1.8 to 2.2 g / mL.

5. Use of the traditional Chinese medicine complex according to any one of claims 1 to 5 in the preparation of a medicament for treating obesity of the spleen deficiency and dampness excess type in children.

6. The use according to claim 5, characterized in that: The dosage form of the drug includes tablets, pills, ointments, powders, oral liquids, granules or capsules.

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