Sample analyzer

Abstract

The invention is applicable to the field of in-vitro diagnostic equipment, and discloses a sample analyzer. The sample analyzer comprises a sample distribution device, a reagent distribution device and a detection device, the sample distribution device comprises a first sample dispensing assembly and a second sample dispensing assembly, and the first sample dispensing assembly comprises a first sample needle and a first suction and injection power component; the first suction and injection power part is used for providing driving force for the first sample needle to execute suction and injection actions; the second sample dispensing assembly comprises a second sample needle and a second suction and injection power part, the second suction and injection power part is used for providing driving force for the second sample needle to execute suction and injection actions, and the first sample needle and the second sample needle are two sample needles capable of independently executing sample dispensing actions; and the first sucking and injecting power part and the second sucking and injecting power part are the same sucking and injecting power part. The detection efficiency of the sample analyzer can be improved.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of in-vitro diagnostic equipment, in particular to a sample analyzer. BACKGROUND

[0002] A sample analyzer provided by the prior art adopts a single-needle pipetting device to dispense liquid, i.e. all the suction and dispensing actions of the same kind of liquid are performed by a single pipetting needle of a single pipetting device, i.e. the dispensing of the same kind of liquid in all detection items in the sample analyzer is performed by the same pipetting needle, for example, the sample dispensing actions of all detection items in the sample analyzer are performed by the same sample needle, and the reagent dispensing actions of all detection items are performed by the same reagent needle. Since the pipetting speed of the single-needle pipetting device has an upper limit, the sample detection speed of the whole machine is also limited, which is not conducive to the improvement of the detection speed of the sample analyzer. In order to improve the detection speed of the sample analyzer, the related technology proposes a scheme of using a double-needle pipetting device or a three-needle pipetting device or even more needle pipetting devices to dispense samples or reagents, i.e. using two sample needles or three sample needles or more sample needles to perform sample dispensing actions respectively, or using two reagent needles or three reagent needles or more reagent needles to perform reagent dispensing actions respectively. When using a double-needle pipetting device or a three-needle pipetting device or even more needle pipetting devices to dispense samples or reagents, there will be differences in dispensing accuracy when different pipetting needle channels dispense the same kind of liquid, which may cause the precision of the whole machine to not meet the performance requirements of clinical analysis.

[0003] To solve the problem of precision decline caused by pipetting with different pipetting needles, the solutions proposed by the related art mainly include the following two schemes: (1) Scheme one, each pipetting needle is used to perform pipetting action in different detection items, that is, different pipetting needles are responsible for pipetting action of different specified detection items respectively, and do not interfere with each other. In this scheme, each pipetting needle performs clinical calibration of the corresponding specified item. Scheme two, each detection item is calibrated for each pipetting needle. Thus, several pipetting needles require several sets of calibration standards and corresponding reagents. However, both of the two schemes have deficiencies in specific application, which are embodied in: (1) In scheme one, since each pipetting needle is used to perform pipetting action in different specified detection items, when there are many samples to perform a certain detection item in a time period, a phenomenon of long queue of many samples waiting for pipetting action under the pipetting needle corresponding to the detection item will occur, and other pipetting needles are in idle state, which causes great waste of resources and leads to speed reduction in a large number of clinical detection scenarios, thereby greatly reducing the actual detection efficiency of the sample analyzer, which is contrary to the speed-up goal of using multiple needles for pipetting. (2) In scheme two, since each detection item needs to be calibrated for each pipetting needle respectively, on the one hand, the use amount of calibration standards and corresponding reagents is increased, thereby increasing the calibration cost; on the other hand, the calibration efficiency is reduced; and on the other hand, since the performance transmission chain of the clinical results and the pipetting accuracy is long, or the accuracy difference of different pipetting needles cannot be reflected by single detection clinical data, the clinical item calibration may cause more uncontrollable calibration deviation. SUMMARY

[0004] The first object of the present application is to provide a sample analyzer which aims to solve the technical problem that the detection efficiency and calibration cost cannot be considered when a multi-needle pipetting device is used to perform pipetting action of the same liquid in the related art.

[0005] To achieve the above object, the present application provides a solution: a sample analyzer, comprising:

[0006] a sample dispensing device, configured to perform a sample dispensing action of: sucking a sample from a sample container, and dispensing at least part of the sucked sample into a reaction container;

[0007] a reagent dispensing device, configured to perform a reagent dispensing action of: sucking a reagent from a reagent container, and dispensing at least part of the sucked reagent into the reaction container;

[0008] a detection device, configured to detect a to-be-tested liquid made of at least the sample dispensed by the sample dispensing device and the reagent dispensed by the reagent dispensing device;

[0009] The sample dispensing device comprises a first sample dispensing assembly and a second sample dispensing assembly. The first sample dispensing assembly comprises a first sample needle and a first suction driving component for providing driving force for the first sample needle to perform a suction action. The second sample dispensing assembly comprises a second sample needle and a second suction driving component for providing driving force for the second sample needle to perform a suction action. The first sample needle and the second sample needle are two sample needles capable of independently performing the sample dispensing action. The first suction driving component and the second suction driving component are the same suction driving component.

[0010] As an implementation form, the first sample dispensing assembly further comprises a first cleaning driving component for driving cleaning liquid from a first cleaning liquid supply device to flush the first sample needle.

[0011] The second sample dispensing assembly further comprises a second cleaning driving component for driving cleaning liquid from the first cleaning liquid supply device to flush the second sample needle.

[0012] The sample analyzer further comprises a controller configured to control the second cleaning driving component to drive cleaning liquid to flush the second sample needle when the first suction driving component is controlled to drive the first sample needle to perform the sample dispensing action, and / or control the first cleaning driving component to drive cleaning liquid to flush the first sample needle when the second suction driving component is controlled to drive the second sample needle to perform the sample dispensing action.

[0013] As an implementation form, the first sample dispensing assembly further comprises a first cleaning control valve and a first sample adding control valve. The first cleaning control valve is arranged between the first cleaning driving component and the first sample needle to control the opening and closing of a liquid path between the first cleaning driving component and the first sample needle. The first sample adding control valve is arranged between the first suction driving component and the first sample needle to control the opening and closing of a liquid path between the first suction driving component and the first sample needle.

[0014] The second sample dispensing assembly further comprises a second cleaning control valve and a second sample adding control valve. The second cleaning control valve is arranged between the second cleaning driving component and the second sample needle to control the opening and closing of a liquid path between the second cleaning driving component and the second sample needle. The second sample adding control valve is arranged between the first suction driving component and the second sample needle to control the opening and closing of a liquid path between the first suction driving component and the second sample needle.

[0015] The controller is further configured to: when it is required to control the first sample dispensing assembly to perform the sample dispensing action, control the first washing control valve and the second sample adding control valve to be closed, control the first sample adding control valve and the second washing control valve to be opened, control the first sample suction power component to be started to drive the first sample needle to perform the sample dispensing action, and control the second washing driving component to be started to drive the washing liquid to flush the second sample needle; and when it is required to control the second sample dispensing assembly to perform the sample dispensing action, control the second washing control valve and the first sample adding control valve to be closed, control the second sample adding control valve and the first washing control valve to be opened, control the second sample suction power component to be started to drive the second sample needle to perform the sample dispensing action, and control the first washing driving component to be started to drive the washing liquid to flush the first sample needle.

[0016] As an implementation form, the first sample dispensing assembly further comprises a third washing control valve and a first liquid path, the first liquid path is connected between the first washing driving component and the first sample suction power component, the first washing driving component is configured to drive the washing liquid from the first washing liquid supply device to flow towards the first liquid path, the third washing control valve is arranged on the first liquid path to control the opening and closing of the first liquid path; the second sample dispensing assembly further comprises a fourth washing control valve and a second liquid path, the second liquid path is connected between the second washing driving component and the first sample suction power component, the second washing driving component is configured to drive the washing liquid from the first washing liquid supply device to flow towards the second liquid path, the fourth washing control valve is arranged on the second liquid path to control the opening and closing of the second liquid path; the first washing driving component and the second washing driving component are the same component, the third washing control valve and the fourth washing control valve are the same component, and the first liquid path and the second liquid path are the same liquid path.

[0017] As an implementation form, the sample analyzer further comprises a controller, the controller is configured to perform the following item calibration process for the first detection item: control the first sample dispensing assembly to suck the item calibration sample from the calibration sample container and dispense it into the reaction container, control the reagent dispensing device to suck the reagent from the reagent container and dispense it into the reaction container; control the detection device to detect the calibration liquid at least made of the item calibration sample and the reagent in the reaction container, and obtain the first calibration data corresponding to the first detection item according to the detection information fed back by the detection device.

[0018] The controller is further configured to perform a second detection procedure of the first detection item, including: controlling the second sample dispensing assembly to perform the sample dispensing action, controlling the reagent dispensing device to perform the reagent dispensing action, controlling the sample detection device to detect the to-be-tested liquid made of at least the sample dispensed by the second sample dispensing assembly and the reagent dispensed by the reagent dispensing device, obtaining second detection data according to detection information fed back by the detection device, and obtaining a second detection result according to the second detection data and the first calibration data corresponding to the first detection item.

[0019] As an implementation form, the sample analyzer pre-stores preset conditions, and the preset conditions at least include one of the following: a preset time length is reached since the last time the item calibration procedure is performed; a preset time point of a preset maintenance period is reached; information of a newly loaded reagent container is obtained; information that a quality control detection result is wrong is obtained.

[0020] The controller is further configured to perform the item calibration procedure when the preset conditions are met.

[0021] As an implementation form, a deviation of sample dispensing accuracy of the first sample dispensing assembly and sample dispensing accuracy of the second sample dispensing assembly is less than or equal to a first preset value, the first preset value is greater than or equal to zero and less than or equal to 5%; and / or,

[0022] The sample analyzer further includes a controller, and the controller is configured to control the first sample dispensing assembly and the second sample dispensing assembly to respectively perform the sample dispensing action of the same detection item of two samples.

[0023] As an implementation form, the first preset value is less than or equal to 2%.

[0024] As an implementation form, the sample analyzer further includes a controller and a reaction device, the reaction device is used to carry a reaction container to perform an incubation action of incubating a liquid containing at least a sample and a reagent; the controller is configured to control the first sample dispensing assembly and the second sample dispensing assembly to respectively perform the sample dispensing action of the same detection item of two samples, control the same reagent dispensing device to respectively perform the reagent dispensing action of the same detection item of the two samples, control the same reaction device to respectively perform the incubation action of the same detection item of the two samples, and control the same detection device to respectively detect to-be-tested liquids made of the two samples and reagents.

[0025] As an implementation form, the reagent dispensing device performs the reagent dispensing action, which includes: sucking the magnetic bead reagent from the first reagent container and dispensing the magnetic bead reagent into the reaction container; and sucking the marker reagent from the second reagent container and dispensing the marker reagent into the reaction container.

[0026] The reaction device is configured to carry the reaction container to perform an incubation action, which includes: incubating at least the sample, the magnetic bead reagent, and the marker reagent to prepare a first reaction liquid.

[0027] The sample analyzer further includes a magnetic separation device and a substrate dispensing device, wherein the magnetic separation device is configured to perform a magnetic separation and cleaning operation on the first reaction liquid to prepare a second reaction liquid.

[0028] The substrate dispensing device is configured to perform a substrate dispensing action, which includes: sucking the luminescent substrate reagent from a substrate reagent container, and dispensing at least part of the sucked luminescent substrate reagent into the reaction container loaded with the second reaction liquid, so that the second reaction liquid and the luminescent substrate reagent prepare the to-be-tested liquid.

[0029] The detection device is configured to detect the luminescent intensity of the to-be-tested liquid.

[0030] The controller is further configured to: control the same magnetic separation device to perform the magnetic separation and cleaning operation of the same detection item of two samples, respectively; and control the same substrate dispensing device to perform the substrate dispensing action of the same detection item of the two samples, respectively.

[0031] As an implementation form, the reagent dispensing device includes at least two reagent dispensing assemblies that are capable of performing the reagent dispensing action independently at least in part and have calibration parameters for calibration; and / or,

[0032] The sample analyzer further includes a reaction device, which is configured to carry a reaction container to perform an incubation action, which includes: incubating at least a liquid containing a sample and a reagent; the reaction device includes at least two incubation assemblies that are capable of performing the incubation action independently at least in part and have calibration parameters for calibration; and / or,

[0033] The detection device includes at least two detection assemblies that are capable of detecting the to-be-tested liquid independently at least in part and have calibration parameters for calibration.

[0034] A third object of the present application is to provide a sample analyzer, which includes:

[0035] A sample dispensing device is configured to perform a sample dispensing action, which includes: sucking a sample from a sample container, and dispensing at least part of the sucked sample into a reaction container.

[0036] A reagent dispensing device for performing a reagent dispensing action of: sucking reagent from a reagent container, and dispensing at least part of the sucked reagent into a reaction container;

[0037] A detection device for detecting a to-be-tested liquid made of at least a sample dispensed by the sample dispensing device and a reagent dispensed by the reagent dispensing device;

[0038] The reagent dispensing device comprises a first reagent dispensing assembly and a second reagent dispensing assembly. The first reagent dispensing assembly comprises a first reagent needle and a third suction power component for providing driving force for the first reagent needle to perform a suction action. The second reagent dispensing assembly comprises a second reagent needle and a fourth suction power component for providing driving force for the second reagent needle to perform a suction action. The first reagent needle and the second reagent needle are two reagent needles capable of independently performing the reagent dispensing action. The third suction power component and the fourth suction power component are the same suction power component.

[0039] As an implementation form, the sample analyzer further comprises a reaction device, a magnetic separation device, a substrate dispensing device, and a controller. The reagent dispensing device performs the reagent dispensing action, which comprises: sucking magnetic bead reagent from a first reagent container and dispensing the magnetic bead reagent into a reaction container, and sucking marker reagent from a second reagent container and dispensing the marker reagent into the reaction container. The reaction device is used to load the reaction container to perform an incubation action of: incubating a liquid containing at least a sample, the magnetic bead reagent, and the marker reagent to make a first reaction liquid. The magnetic separation device is used to perform a magnetic separation and cleaning operation on the first reaction liquid to make a second reaction liquid. The substrate dispensing device is used to perform a substrate dispensing action of: sucking luminescent substrate reagent from a substrate reagent container, and dispensing at least part of the sucked luminescent substrate reagent into a reaction container loaded with the second reaction liquid, so that the fourth reaction liquid and the luminescent substrate reagent make the to-be-tested liquid. The detection device is used to perform a detection action of: detecting the luminescent intensity of the to-be-tested liquid. The controller is configured to: control the same sample dispensing device to perform the sample dispensing action of the same detection item of two samples, respectively; control the first reagent dispensing assembly and the second reagent dispensing assembly to perform the reagent dispensing action of the same detection item of the two samples, respectively; control the same reaction device to perform the incubation action of the same detection item of the two samples, respectively; control the same magnetic separation device to perform the magnetic separation and cleaning operation of the same detection item of the two samples, respectively; control the same substrate dispensing device to perform the substrate dispensing action of the same detection item of the two samples, respectively; and control the same detection device to perform the detection action of the same detection item of the two samples, respectively; and / or,

[0040] The first reagent dispensing assembly further comprises a third cleaning driving component configured to at least drive the cleaning liquid from the second cleaning liquid supply device to flush the first reagent needle; the second reagent dispensing assembly further comprises a fourth cleaning driving component configured to at least drive the cleaning liquid from the second cleaning liquid supply device to flush the second reagent needle; the sample analyzer further comprises a controller configured to: control the fourth cleaning driving component to drive the cleaning liquid to flush the second reagent needle while controlling the third suction driving component to drive the first reagent needle to perform the reagent dispensing action; and / or control the fourth cleaning driving component to drive the cleaning liquid to flush the first reagent needle while controlling the fourth suction driving component to drive the second reagent needle to perform the reagent dispensing action.

[0041] A third object of the present application is to provide a sample analyzer comprising:

[0042] a pipetting device configured to perform a liquid dispensing action of: sucking a sample from a sample container and dispensing at least part of the sucked sample into a reaction container; and sucking a reagent from a reagent container and dispensing at least part of the sucked reagent into the reaction container;

[0043] a detection device configured to detect a to-be-tested liquid made of at least the sample and the reagent dispensed by the pipetting device;

[0044] wherein the pipetting device comprises a first pipetting assembly and a second pipetting assembly, the first pipetting assembly comprises a first pipetting needle and a first pipetting power source configured to provide driving force for the first pipetting needle to perform a suction action, and the second pipetting assembly comprises a second pipetting needle and a second pipetting power source configured to provide driving force for the second pipetting needle to perform a suction action, the first pipetting needle and the second pipetting needle are two pipetting needles capable of independently performing the reagent dispensing action, and the first pipetting power source and the second pipetting power source are the same pipetting power source.

[0045] As an implementation, the sample analyzer further comprises a reaction device, a magnetic separation device, a substrate dispensing device, and a controller; the pipetting device aspirates reagents from reagent containers and dispenses at least part of the aspirated reagents into the reaction container, including: aspirating magnetic bead reagents from a first reagent container and dispensing into the reaction container, aspirating marker reagents from a second reagent container and dispensing into the reaction container; the reaction device is used to carry the reaction container to perform the following incubation actions: incubating a liquid containing at least the sample, the magnetic bead reagents, and the marker reagents to produce a first reaction liquid; the magnetic separation device is used to perform a magnetic separation and washing operation on the first reaction liquid to produce a second reaction liquid; the substrate dispensing device is used to perform the following substrate dispensing action: aspirating luminescent substrate reagents from a substrate reagent container and dispensing at least part of the aspirated luminescent substrate reagents into the reaction container loaded with the second reaction liquid, so that the fourth reaction liquid and the luminescent substrate reagents produce the to-be-tested liquid; the detection device is used to perform the following detection action: detecting the luminescent intensity of the to-be-tested liquid; the controller is configured to: control the first pipetting assembly and the second pipetting assembly to respectively perform the liquid dispensing action of the same detection item of the two samples, control the same reaction device to respectively perform the incubation action of the same detection item of the two samples, control the same magnetic separation device to respectively perform the magnetic separation and washing operation of the same detection item of the two samples, control the same substrate dispensing device to respectively perform the substrate dispensing action of the same detection item of the two samples, and control the same detection device to respectively perform the detection action of the same detection item of the two samples; and / or,

[0046] The first pipetting assembly further comprises a fifth cleaning driving component, which is used to at least drive cleaning liquid from the third cleaning liquid supply device to flush the first pipetting needle; the second pipetting assembly further comprises a sixth cleaning driving component, which is used to at least drive cleaning liquid from the third cleaning liquid supply device to flush the second pipetting needle; the sample analyzer further comprises a controller, which is configured to: when controlling the first pipetting power source to drive the first pipetting needle to perform the liquid dispensing action, control the sixth cleaning driving component to drive cleaning liquid to flush the second pipetting needle; and / or, when controlling the second pipetting power source to drive the second pipetting needle to perform the liquid dispensing action, control the sixth cleaning driving component to drive cleaning liquid to flush the first pipetting needle.

[0047] The sample analyzer provided by the present invention is configured as a sample dispensing device comprising a first sample dispensing assembly and a second sample dispensing assembly, the first sample dispensing assembly comprising a first sample needle and a first aspiration power component, the second sample dispensing assembly comprising a second sample needle and a second aspiration power component, the first sample needle and the second sample needle being configured to be able to independently perform sample dispensing actions, the first aspiration power component and the second aspiration power component being configured to be the same aspiration power component, that is, the first sample needle and the second sample needle share a common aspiration power source, which is equivalent to providing a sample dispensing device with a single aspiration power source and multiple sample needles. In this way, by sharing the common aspiration power source, the number of the first sample dispensing assembly can be reduced. The hardware differences between the first sample dispensing component and the second sample dispensing component are conducive to reducing the accuracy differences in the sample distribution volume between the first sample dispensing component and the second sample dispensing component, thereby meeting the need for consistency in sample distribution volume among multiple sample needles without the need for the entire machine to perform a sample addition calibration process, and enabling the first sample dispensing component and the second sample dispensing component to perform sample distribution actions for the same test item of two samples, thereby meeting the accuracy requirements of the sample distribution volume and the precision requirements of the clinical test item test, thereby facilitating the full utilization of the first sample needle and the second sample needle to achieve the purpose of improving the test efficiency of the sample analyzer, and effectively avoiding the undesirable phenomenon that one sample needle is too busy and the other sample needle is idle. Since the first sample dispensing component and the second sample dispensing component can perform sample distribution actions for the same test item of two samples by sharing the suction and injection power component, there is no need for additional calibration of clinical test items separately, nor is there a need to assign different test items to different sample needles, thereby achieving a good balance between test efficiency and calibration costs. In addition, the first sample needle and the second sample needle share a dispensing power component, which can save the cost of one dispensing power component while improving detection efficiency, thereby balancing the detection efficiency and cost of the sample analyzer. BRIEF DESCRIPTION OF THE DRAWINGS

[0048] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments or the description of the prior art. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on the structures shown in these drawings without paying any creative work.

[0049] Figure 1 1 is a schematic diagram of the composition of a sample analyzer provided in Example 1 of the present invention;

[0050] Figure 2 is a structural diagram of a sample analyzer provided in Example 1 of the present invention;

[0051] Figure 3is a schematic diagram of a liquid path of a sample dispensing device provided by Embodiment One of the present application;

[0052] Figure 4 is a schematic diagram of a liquid path of a first sample dispensing assembly provided by Embodiment One of the present application;

[0053] Figure 5 is a schematic diagram of a liquid path of a second sample dispensing assembly provided by Embodiment One of the present application;

[0054] Figure 6 is a schematic diagram of a liquid path of a sample dispensing device provided by Embodiment Two of the present application;

[0055] Figure 7 is a schematic diagram of a structure of a sample analyzer provided by Embodiment Four of the present application.

[0056] BRIEF DESCRIPTION OF DRAWINGS 10, sample analyzer; 100, sample dispensing device; 110, first sample dispensing assembly; 111, first sample needle; 112, first suction and injection power component; 113, first cleaning driving component; 114, third cleaning control valve; 115, first liquid path; 116, first cleaning control valve; 117, first sample adding control valve; 118, third liquid path; 119, fourth liquid path; 120, second sample dispensing assembly; 121, second sample needle; 122, second suction and injection power component; 123, second cleaning driving component; 124, fourth cleaning control valve; 125, second liquid path; 126, second cleaning control valve; 127, second sample adding control valve; 128, fifth liquid path; 129, sixth liquid path; 200, reagent dispensing device; 210, first reagent dispensing assembly; 220, second reagent dispensing assembly; 300, detection device; 400, controller; 500, magnetic separation device; 600, sample management device; 700, sample conveying device; 800, reagent storage device; 900, reaction device; 101, substrate dispensing device; 102, reaction container providing device; 103, reaction container recycling device; 104, transfer device; 20, first cleaning liquid supply device. DETAILED DESCRIPTION

[0057] The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by a person of ordinary skill in the art without creative work fall within the protection scope of the present application.

[0058] In addition, the technical solutions in each embodiment can be combined with each other, but it must be based on the fact that a person of ordinary skill in the art can realize it.

[0059] The embodiment of the present invention is applicable to a sample analyzer that needs to pipette the same target liquid through at least two pipettes. The target liquid includes but is not limited to samples, reagents, etc.

[0060] Example 1:

[0061] like Figures 1 to 5 As shown, a sample analyzer 10 provided in a first embodiment of the present invention includes a sample dispensing device 100 and a detection device 300. The sample dispensing device 100 is configured to perform the following sample dispensing action: aspirating a sample from a sample container and dispensing at least a portion of the aspirated sample into a reaction container. The reaction container provides a reaction site for the sample. The detection device 300 is configured to perform a detection action: testing a test fluid composed of at least the sample.

[0062] As an embodiment, the sample dispensing device 100 includes a first sample dispensing component 110 and a second sample dispensing component 120. The first sample dispensing component 110 and the second sample dispensing component 120 are respectively used to perform the following sample dispensing actions: aspirating a sample from a sample container and dispensing at least a portion of the aspirated sample into a reaction container. The first sample dispensing component 110 and the second sample dispensing component 120 are two dispensing components whose at least some components can independently perform the sample dispensing action. The first sample dispensing component 110 and the second sample dispensing component 120 share at least some components and at least some components are not shared. In this embodiment, the first sample dispensing component 110 and the second sample dispensing component 120 can both be used to perform the sample dispensing action. In this way, when a batch of samples need to be detected by the sample analyzer 10, the first sample dispensing component 110 can perform the sample dispensing action for a portion of the samples, and the second sample dispensing component 120 can perform the sample dispensing action for another portion of the samples, thereby improving the distribution efficiency of the batch samples and further improving the detection efficiency of the entire machine.

[0063] As an embodiment, the first sample dispensing assembly 110 and the second sample dispensing assembly 120 share at least some components. In this embodiment, the first sample dispensing assembly 110 and the second sample dispensing assembly 120 share at least some components, which can reduce the hardware differences between the first sample dispensing assembly 110 and the second sample dispensing assembly 120, thereby facilitating reducing the differences in the sample amounts dispensed by the first sample dispensing assembly 110 and the second sample dispensing assembly 120. This can further meet the requirement of consistent sample amount dispensing across multiple sample needles without requiring a sample calibration process for the entire machine.

[0064] As an implementation form, the first sample dispensing assembly 110 comprises a first sample needle 111, and the second sample dispensing assembly 120 comprises a second sample needle 121. The first sample needle 111 and the second sample needle 121 are two sample needles capable of independently performing sample dispensing actions. The first sample needle 111 and the second sample needle 121 are two different sample needles. Here, different sample needles mainly refer to different sample needles, and do not refer to different shapes and sizes of the two sample needles. That is, the shapes and sizes of the two sample needles can be the same or different. In this embodiment, the first sample dispensing assembly 110 and the second sample dispensing assembly 120 do not share a sample needle. In this way, the sample dispensing device 100 has at least two sample needles that can work at the same time (here, working at the same time can mean that the two sample needles perform the same action at the same time; or one sample needle performs an action, and the other sample needle performs another action). Therefore, the batch sample dispensing efficiency can be improved.

[0065] As an implementation form, the first sample dispensing assembly 110 further comprises a first suction power component 112 for providing driving force for the first sample needle 111 to perform a suction action. The second sample dispensing assembly 120 further comprises a second suction power component 122 for providing driving force for the second sample needle 121 to perform a suction action. The first suction power component 112 and the second suction power component 122 are the same suction power component. Through analysis, in a multi-sample needle system, the main factor affecting the accuracy difference of the multi-sample needle system is the suction power source, which accounts for more than 70%. In order to reduce the sample dispensing amount difference caused by the suction power source, the sample dispensing device 100 of the present embodiment is designed as a single dispensing power source multi-sample needle channel. The multi-sample needle system shares a dispensing power source to dispense samples, which can effectively reduce the difference between the multi-sample needle channels. The design of the shared power source can reduce more than 70% of the accuracy difference of the multi-sample needle system. After calculation, the precision requirements of sample dispensing and clinical detection projects can be directly met, and there is no need to additionally calibrate or allocate different detection projects to different sample needles. The calibration cost can be greatly saved, and the detection efficiency can be improved.

[0066] As an implementation form, the sample analyzer 10 further comprises a controller 400, which is used to control at least the first sample dispensing assembly 110, the second sample dispensing assembly 120, and the detection device 300 to work.

[0067] As an implementation, the first sample dispensing assembly 110 further comprises a first washing driving component 113, which is configured to drive the washing liquid from the first washing liquid supply device 20 to flush the first sample needle 111; and the second sample dispensing assembly 120 further comprises a second washing driving component 123, which is configured to drive the washing liquid from the first washing liquid supply device 20 to flush the second sample needle 121. The controller 400 is configured to control the second washing driving component 123 to drive the washing liquid to flush the second sample needle 121 when the first sample needle 111 is controlled by the first suction driving component 112 to perform the sample dispensing action; and / or control the first washing driving component 113 to drive the washing liquid to flush the first sample needle 111 when the second sample needle 121 is controlled by the second suction driving component 122 to perform the sample dispensing action. In this embodiment, the first sample dispensing assembly 110 and the second sample dispensing assembly 120 are configured to alternate the sample dispensing and washing, i.e., one of the first sample dispensing assembly 110 and the second sample dispensing assembly 120 performs the sample dispensing action while the other performs the washing action, so that the influence of the sample needle washing time on the sample detection efficiency can be reduced.

[0068] As an implementation, the first sample dispensing assembly 110 further comprises a first washing control valve 116 and a first sample adding control valve 117. The first washing control valve 116 is arranged between the first washing driving component 113 and the first sample needle 111 to control the opening and closing of the liquid path between the first washing driving component 113 and the first sample needle 111. The first sample adding control valve 117 is arranged between the first suction driving component 112 and the first sample needle 111 to control the opening and closing of the liquid path between the first suction driving component 112 and the first sample needle 111.

[0069] As an implementation, the first sample dispensing assembly 110 further comprises a third liquid path 118 and a fourth liquid path 119. The third liquid path 118 is connected between the first washing driving component 113 and the first sample needle 111. The fourth liquid path 119 is connected between the first suction driving component 112 and the first sample needle 111. The first washing control valve 116 is arranged on the third liquid path 118 to control the opening and closing of the third liquid path 118. The first sample adding control valve 117 is arranged on the fourth liquid path 119 to control the opening and closing of the fourth liquid path 119.

[0070] As an implementation, the second sample dispensing assembly 120 further comprises a second washing control valve 126 and a second sample adding control valve 127, the second washing control valve 126 is arranged between the second washing driving component 123 and the second sample needle 121 to control the opening and closing of the liquid path between the second washing driving component 123 and the second sample needle 121, and the second sample adding control valve 127 is arranged between the first suction driving component 112 and the second sample needle 121 to control the opening and closing of the liquid path between the first suction driving component 112 and the second sample needle 121.

[0071] As an implementation, the second sample dispensing assembly 120 further comprises a fifth liquid path 128 and a sixth liquid path 129, the fifth liquid path 128 is connected between the second washing driving component 123 and the second sample needle 121, and the sixth liquid path 129 is connected between the first suction driving component 112 and the second sample needle 121, the second washing control valve 126 is arranged on the fifth liquid path 128 to control the opening and closing of the fifth liquid path 128, and the second sample adding control valve 127 is arranged on the sixth liquid path 129 to control the opening and closing of the sixth liquid path 129.

[0072] As an implementation, the controller 400 is further configured to: when it is required to control the first sample dispensing assembly 110 to perform a sample dispensing action, control the third washing control valve 114, the fourth washing control valve 124, the first washing control valve 116 and the second sample adding control valve 127 to be closed, control the first sample adding control valve 117 and the second washing control valve 126 to be opened, control the first suction driving component 112 to be started to drive the first sample needle 111 to perform the sample dispensing action, and control the second washing driving component 123 to be started to drive the washing liquid to flush the second sample needle 121; when it is required to control the second sample dispensing assembly 120 to perform a sample dispensing action, control the third washing control valve 114, the fourth washing control valve 124, the second washing control valve 126 and the first sample adding control valve 117 to be closed, control the second sample adding control valve 127 and the first washing control valve 116 to be opened, control the second suction driving component 122 to be started to drive the second sample needle 121 to perform the sample dispensing action, and control the first washing driving component 113 to be started to drive the washing liquid to flush the first sample needle 111. With this implementation, the design requirement that one sample needle performs a sample dispensing action and the other sample needle performs a washing action can be met.

[0073] As an implementation, the first sample dispensing assembly 110 and the second sample dispensing assembly 120 can share other components in addition to sharing the dispensing power source, so as to share more components as possible to ensure the consistency of the sample dispensing amount of the two dispensing assemblies.

[0074] As an implementation, the first cleaning driving component 113 and the second cleaning driving component 123 are the same component, i.e. the first sample needle 111 and the second sample needle 121 share the cleaning power source. In this implementation, the first sample dispensing assembly 110 and the second sample dispensing assembly 120 share the dispensing power source and the cleaning power source, which is conducive to further reducing the difference in hardware between the first sample dispensing assembly 110 and the second sample dispensing assembly 120, thereby not only ensuring the consistency of the sample dispensing amount of the first sample dispensing assembly 110 and the second sample dispensing assembly 120, but also reducing the cost of the sample dispensing device 100.

[0075] As an implementation, the first sample dispensing assembly 110 further comprises a third cleaning control valve 114 and a first liquid path 115, the first liquid path 115 is connected between the first cleaning driving component 113 and the first dispensing power component 112, the first cleaning driving component 113 is used at least for driving the cleaning liquid from the first cleaning liquid supply device 20 to flow towards the first liquid path 115, and the third cleaning control valve 114 is arranged on the first liquid path 115 to control the opening and closing of the first liquid path 115; the second sample dispensing assembly 120 further comprises a fourth cleaning control valve 124 and a second liquid path 125, the second liquid path 125 is connected between the second cleaning driving component 123 and the first dispensing power component 112, the second cleaning driving component 123 is used at least for driving the cleaning liquid from the first cleaning liquid supply device 20 to flow towards the second liquid path 125, and the fourth cleaning control valve 124 is arranged on the second liquid path 125 to control the opening and closing of the second liquid path 125; the third cleaning control valve 114 and the fourth cleaning control valve 124 are the same component, and the first liquid path 115 and the second liquid path 125 are the same liquid path. In this implementation, the first sample dispensing assembly 110 and the second sample dispensing assembly 120 share the dispensing power source, the cleaning power source, and at least part of the cleaning control valve and the liquid path, which is conducive to further reducing the difference in hardware between the first sample dispensing assembly 110 and the second sample dispensing assembly 120, and further reducing the cost of the sample dispensing device 100. Of course, as an alternative implementation, the first sample dispensing assembly 110 and the second sample dispensing assembly 120 can not share the cleaning control valve and the liquid path in specific applications, i.e. in the alternative implementation, the third cleaning control valve 114 and the fourth cleaning control valve 124 are two components that control the opening and closing of the liquid path independently of each other, and the first liquid path 115 and the second liquid path 125 are two liquid paths arranged in parallel.

[0076] As an implementation, the controller 400 is configured to: when it is required to control the first sample dispensing assembly 110 to perform a sample dispensing action, control the third washing control valve 114, the fourth washing control valve 124, the first washing control valve 116, and the second sample control valve 127 to be closed, control the first sample control valve 117 and the second washing control valve 126 to be opened, control the first suction power component 112 to be started to drive the first sample needle 111 to perform the sample dispensing action, and control the second washing driving component 123 to be started to drive the washing liquid to flush the second sample needle 121; when it is required to control the second sample dispensing assembly 120 to perform a sample dispensing action, control the third washing control valve 114, the fourth washing control valve 124, the second washing control valve 126, and the first sample control valve 117 to be closed, control the second sample control valve 127 and the first washing control valve 116 to be opened, control the second suction power component 122 to be started to drive the second sample needle 121 to perform the sample dispensing action, and control the first washing driving component 113 to be started to drive the washing liquid to flush the first sample needle 111. With this implementation, the design requirement that one sample needle performs a sample dispensing action and the other sample needle performs a washing action can be met.

[0077] As an implementation, the first sample dispensing assembly 110 further comprises a first movement power component for driving the first sample needle 111 to move in space so as to move the first sample needle 111 to different stations, such as a standby station, a sample suction station, a dispensing station, a washing station, etc.

[0078] As an implementation, the second sample dispensing assembly 120 further comprises a second movement power component for driving the second sample needle 121 to move in space so as to move the second sample needle 121 to different stations, such as a standby station, a sample suction station, a dispensing station, a washing station, etc.

[0079] As an implementation, the controller 400 is configured to control the first sample dispensing assembly 110 and the second sample dispensing assembly 120 to perform a sample dispensing action of the same detection item of two samples, respectively.

[0080] As an implementation form, the deviation of the sample dispensing accuracy of the first sample dispensing assembly 110 and the sample dispensing accuracy of the second sample dispensing assembly 120 is less than or equal to a first preset value, the first preset value is greater than or equal to zero and less than or equal to 5%. In this implementation form, the deviation of the sample dispensing accuracy of the first sample dispensing assembly 110 and the sample dispensing accuracy of the second sample dispensing assembly 120 is reduced mainly by the way that the first sample dispensing assembly 110 shares part of components with the second sample dispensing assembly 120, so that the sample dispensing amount of the first sample dispensing assembly 110 in the sample dispensing action and the sample dispensing amount of the second sample dispensing assembly 120 in the sample dispensing action are basically consistent, thereby facilitating to reduce the influence on the sample detection result when the first sample dispensing assembly 110 and the second sample dispensing assembly 120 respectively perform the sample dispensing action, and further facilitating to ensure the accuracy of the detection result when the first sample needle 111 and the second sample needle 121 are used to perform the sample dispensing action of the same detection item.

[0081] As an implementation form, the first preset value is less than or equal to 2%, so that the difference between the sample dispensing amount of the first sample dispensing assembly 110 in the sample dispensing action and the sample dispensing amount of the second sample dispensing assembly 120 in the sample dispensing action is further reduced, thereby facilitating to ensure the consistency of the sample dispensing amount of the first sample dispensing assembly 110 and the second sample dispensing assembly 120, and further facilitating to further ensure the accuracy of the detection result when the first sample needle 111 and the second sample needle 121 are used to perform the sample dispensing action of the same detection item.

[0082] As an implementation form, the sample analyzer 10 further comprises a reaction device 900, the reaction device 900 is used to carry a reaction container to incubate a sample and a reagent in the reaction container.

[0083] As an implementation form, the sample analyzer 10 further comprises a reagent dispensing device 200, the reagent dispensing device 200 is used to perform a reagent dispensing action of sucking a reagent from a reagent container and dispensing at least part of the sucked reagent into a reaction container. The detection device 300 is used to detect a to-be-detected liquid made of at least a sample dispensed by the sample dispensing device 100 and a reagent dispensed by the reagent dispensing device 200. The sample analyzer 10 of this implementation form is suitable for the scenario that the reagent is dispensed into the reaction container by the reagent dispensing device 200; of course, as an alternative implementation form, the sample analyzer 10 can also not be provided with the reagent dispensing device 200 in specific applications, and this alternative implementation form is suitable for the scenario that the reagent is pre-stored in the reaction container.

[0084] As an implementation, the reagent dispensing device 200 comprises a first reagent dispensing assembly 210, the first reagent dispensing assembly 210 comprising a first reagent needle and a reagent suction power component (i.e., a third suction power component), the reagent suction power component being configured to drive the first reagent needle to suck reagent from the reagent container and to drive the first reagent needle to dispense at least part of the sucked reagent into the reaction container.

[0085] As an implementation, the sample analyzer 10 further comprises a reagent storage device 800, the reagent storage device 800 being configured to store the reagent container, and the reagent dispensing device 200 is configured to suck reagent from the reagent container at the reagent suction position. Of course, as an alternative implementation, the reagent storage device 800 can not be provided in the sample analyzer 10 in specific applications, for example, the reagent container can be placed at the reagent suction position by an operator.

[0086] As an implementation, the controller 400 is configured to perform a first detection procedure as follows: controlling the first sample dispensing assembly 110 to perform a sample dispensing action, controlling the reagent dispensing device 200 to perform a reagent dispensing action, controlling the detection device 300 to detect a to-be-tested liquid made of at least the sample dispensed by the first sample dispensing assembly 110 and the reagent dispensed by the reagent dispensing device 200, obtaining first detection data according to detection information fed back by the detection device 300, and obtaining a first detection result according to the first detection data and the first calibration data. The controller 400 is further configured to perform a second detection procedure as follows: controlling the second sample dispensing assembly 120 to perform a sample dispensing action, controlling the reagent dispensing device 200 to perform a reagent dispensing action, controlling the detection device 300 to detect a to-be-tested liquid made of at least the sample dispensed by the second sample dispensing assembly 120 and the reagent dispensed by the reagent dispensing device 200, obtaining second detection data according to detection information fed back by the detection device 300, and obtaining a second detection result according to the second detection data and the second calibration data. The difference between the first detection procedure and the second detection procedure mainly lies in the sample dispensing assembly used to perform the sample dispensing action, which is embodied in that the sample dispensing action in the first detection procedure is performed by the first sample dispensing assembly 110, and the sample dispensing action in the second detection procedure is performed by the second sample dispensing assembly 120.

[0087] As an implementation, the controller 400 is further configured to control the first sample dispensing assembly 110 and the second sample dispensing assembly 120 to respectively perform sample dispensing actions of the same detection item for two samples, control the same reagent dispensing device 200 to respectively perform reagent dispensing actions of the same detection item for the two samples, control the same reaction device 900 to respectively perform incubation actions of the same detection item for the two samples, and control the same detection device 300 to respectively perform detection on the to-be-tested liquids made of the two samples and reagents. In this implementation, the first detection process and the second detection process share the reagent dispensing device 200, the reaction device 900, and the detection device 300, which helps to ensure the consistency of the reagent system, the reaction system, and the detection system in the first detection process and the second detection process. Thus, as long as the sample amount dispensing difference of the sample dispensing system (i.e., the first sample dispensing assembly 110 and the second sample dispensing assembly 120) is reduced, the consistency of the detection result can be ensured.

[0088] As an implementation, the reaction device 900 includes a first reaction disc for carrying a reaction container to incubate samples and reagents. The detection device 300 includes a first light receiving component for performing optical detection on the to-be-tested liquid in the reaction container. The controller 400 is further configured to control the same reagent suction power component (i.e., the third suction power component) to drive the same first reagent needle to respectively perform reagent dispensing actions of the first detection process and the second detection process, control the same first reaction disc to incubate samples and reagents in the first detection process and samples and reagents in the second detection process, and control the same first light receiving component to respectively perform optical detection of the first detection process and optical detection of the second detection process. In this implementation, the first detection process and the second detection process share the reagent needle, the reagent suction power component, the first reaction disc, and the first light receiving component, which helps to ensure the consistency of the reagent system, the reaction system, and the detection system in the first detection process and the second detection process.

[0089] As an embodiment, the sample analyzer 10 further comprises a magnetic separation device 500 and a substrate dispensing device 101. The reagent dispensing device 200 performs a reagent dispensing action comprising: aspirating a magnetic bead reagent from a first reagent container and dispensing the magnetic bead reagent into a reaction vessel, and aspirating a label reagent from a second reagent container and dispensing the label reagent into the reaction vessel; the reaction device 900 is configured to hold the reaction vessel to perform an incubation action comprising: incubating at least the sample, the magnetic bead reagent, and the label reagent to produce a first reaction solution; the magnetic separation device 500 is configured to perform a magnetic separation and washing operation on the first reaction solution to produce a second reaction solution; the substrate dispensing device 101 is configured to perform a substrate dispensing action comprising: aspirating a luminescent substrate reagent from a substrate reagent container, and dispensing at least a portion of the aspirated luminescent substrate reagent into the reaction vessel holding the second reaction solution to produce a test solution from the second reaction solution and the luminescent substrate reagent; and the detection device 300 is configured to detect the luminescent intensity of the test solution. The magnetic bead reagent is a reagent comprising magnetic beads. The label reagent is an antibody reagent with a luminescent label or an antigen reagent with a luminescent label. Before the magnetic separation and washing operation, the sample and the reagents are subjected to an antigen-antibody binding reaction. During the magnetic separation and washing operation, the following operations are performed: magnetic adsorption, liquid aspiration, addition of a separation solution, mixing, and incubation. The magnetic separation and washing operation is mainly used to wash away impurities in the first reaction solution while retaining a portion of the test solution to obtain a purified second reaction solution. The liquid processed by the magnetic separation device 500 comprises a clear liquid and a magnetic bead liquid. In an embodiment, the clear liquid is treated as waste liquid, and the magnetic bead liquid forms the second reaction solution. In this embodiment, the magnetic bead reagent and the label reagent are two reagents separately packaged in two reagent containers. Of course, in specific applications, as an alternative embodiment, the magnetic bead reagent and the label reagent can be integrated into a single reagent packaged in the same reagent container.

[0090] As an embodiment, the substrate dispensing device 101 is configured to perform a substrate dispensing action on the reaction vessel located in the magnetic separation device 500, and the substrate dispensing device 101 and the reagent dispensing device 200 are two different dispensing devices. Of course, in specific applications, as an alternative embodiment, the reagent dispensing device 200 can perform a substrate dispensing action on the reaction vessel located in the reaction device 900, i.e., the substrate dispensing device 101 and the reagent dispensing device 200 can be the same dispensing device.

[0091] As an implementation, the controller 400 is further configured to control the same magnetic separation device 500 to perform a magnetic separation and washing operation of the same detection item for the two samples respectively, and control the same substrate dispensing device 101 to perform a substrate dispensing action of the same detection item for the two samples respectively. In this embodiment, the first detection process and the second detection process share the reagent dispensing device 200, the reaction device 900, the sample detection device 300, and the magnetic separation device 500 and the substrate dispensing device 101, which helps to ensure the consistency of the reagent system, the reaction system, the magnetic separation system, the substrate system, and the detection system in the first detection process and the second detection process, effectively avoiding the influence of the reagent system, the reaction system, the magnetic separation system, the substrate system, and the detection system on the detection result. Therefore, as long as the sample dispensing system is consistent, the consistency of the detection result can be ensured.

[0092] As an implementation, the reagent suction power component (i.e., the third dispensing power component) is used to drive the first reagent needle to suck the magnetic bead reagent containing magnetic beads from the first reagent container and dispense it into the reaction container, and to drive the first reagent needle to suck the marker reagent containing enzyme from the second reagent container and dispense it into the reaction container. The first reaction disc is used to incubate the sample, the magnetic bead reagent, and the marker reagent in the reaction container. The magnetic separation device 500 is used to perform a magnetic separation and washing action on the liquid in the reaction container after at least the sample, the magnetic bead reagent, and the marker reagent are incubated. The substrate dispensing device 101 includes a substrate needle and a substrate suction power component, and the substrate suction power component is used to drive the substrate needle to perform a substrate dispensing action of sucking the luminescent substrate reagent from the substrate container and dispensing at least part of the sucked luminescent substrate reagent into the reaction container to prepare the to-be-tested liquid. The controller 400 is further configured to control the same reagent suction power component to drive the same first reagent needle to perform the reagent dispensing action of the magnetic bead reagent in the first detection process and the reagent dispensing action of the magnetic bead reagent in the second detection process respectively, control the same reagent suction power component to drive the same first reagent needle to perform the reagent dispensing action of the marker reagent in the first detection process and the reagent dispensing action of the marker reagent in the second detection process respectively, control the same first reaction disc to incubate the sample, the magnetic bead reagent, and the marker reagent in the first detection process and the sample, the magnetic bead reagent, and the marker reagent in the second detection process, control the same magnetic separation device 500 to perform a magnetic separation and washing action on the liquid in the reaction container after at least the sample, the magnetic bead reagent, and the marker reagent are incubated in the first detection process and the second detection process, control the same substrate suction power component to drive the same substrate needle to perform the substrate dispensing action in the first detection process and the substrate dispensing action in the second detection process respectively, and control the same first light receiving component to perform optical detection of the first detection process and optical detection of the second detection process respectively.

[0093] As an implementation, the sample analyzer 10 further comprises a sample management device 600 for placing sample containers to at least implement sample loading, and a sample conveying device 700 for conveying the sample containers output by the sample management device 600 to the sample loading position for sample dispensing by the sample dispensing device 100. The sample management device 600 can implement batch loading of sample containers, specifically, an operator or an operating robot can place sample containers loaded with samples to the sample management device 600, and the sample management device 600 is configured to store the sample containers and dispatch the sample containers loaded with samples to the sample conveying device 700. Of course, in specific applications, the sample analyzer 10 can also not be provided with the sample management device 600 and the sample conveying device 700, for example, as an alternative implementation, the sample containers loaded with samples are placed by an operator to the sample loading position for sample dispensing by the sample dispensing device 100.

[0094] As an implementation, the sample analyzer 10 further comprises a transfer device 104 for transferring reaction containers. The transfer device 104 is configured to perform at least one of the following transfer operations: transferring the sample loading completed reaction containers to the reaction device 900, transferring the incubation completed reaction containers from the reaction device 900 to the magnetic separation device 500; transferring the magnetic separation cleaning completed reaction containers from the magnetic separation device 500 to the detection position for detection; transferring the detection completed reaction containers to the cup throwing position for disposal and recycling.

[0095] As an implementation, the sample analyzer 10 further comprises a reaction container providing device 102 for providing reaction containers and a reaction container recycling device 103 for recycling reaction containers. The sample analyzer 10 further forms a recycling position, and the reaction container recycling device 103 is located below the recycling position. The transfer device 104 is at least configured to transfer the reaction containers from the detection position to the recycling position for release and recycling. In this implementation, the reaction containers are disposable containers, i.e., a reaction container is recycled after completing a detection item. Of course, in specific applications, the reaction containers can also be recycled containers, i.e., a reaction container can be cleaned and reused for other detection items after completing a test item in the sample analyzer 10.

[0096] As an implementation, the controller 400 is further configured to perform a project calibration procedure as follows: controlling one of the first sample dispensing assembly 110 and the second sample dispensing assembly 120 to aspirate a project calibration sample from a calibration sample container and dispense into a reaction container, controlling the reagent dispensing device 200 to aspirate a reagent from a reagent container and dispense into the reaction container; controlling the detection device 300 to detect a calibration solution made at least from the project calibration sample and the reagent in the reaction container, and obtaining calibration data corresponding to the sample detection project according to detection information fed back by the detection device 300. The project calibration procedure is mainly used to obtain calibration data corresponding to the sample detection project, which is used to calibrate the detection information obtained in the first detection procedure and the second detection procedure to obtain the detection result. The sample analyzer 10 can be used to perform multiple different detection projects, and each detection project corresponds to a calibration data. In the present embodiment, since the first sample dispensing assembly 110 and the second sample dispensing assembly 120 perform the same detection project and share the same calibration data, the calibration data of each sample detection project can only need to be performed once by one of the first sample dispensing assembly 110 and the second sample dispensing assembly 120, without the need for the first sample dispensing assembly 110 and the second sample dispensing assembly 120 to perform, and without the need for each clinical project to be calibrated for the first sample dispensing assembly 110 and the second sample dispensing assembly 120 respectively, effectively reducing the calibration cost of the sample analyzer 10.

[0097] As an implementation, the controller 400 is configured to perform a project calibration procedure of the first detection item as follows: control the first sample dispensing assembly 110 to aspirate a project calibration sample from a calibration sample container and dispense into a reaction container, control the reagent dispensing device 200 to aspirate a reagent from a reagent container and dispense into the reaction container; control the detection device 300 to detect a calibration solution made at least from the project calibration sample and the reagent in the reaction container, and obtain first calibration data corresponding to the first detection item according to detection information fed back by the detection device 300; the controller 400 is further configured to perform a second detection procedure of the first detection item as follows: control the second sample dispensing assembly 120 to perform a sample dispensing action, control the reagent dispensing device 200 to perform a reagent dispensing action, control the sample detection device 300 to detect a to-be-detected solution made at least from the sample dispensed by the second sample dispensing assembly 120 and the reagent dispensed by the reagent dispensing device 200, obtain second detection data according to detection information fed back by the detection device 300, and obtain a second detection result according to the second detection data and the first calibration data corresponding to the first detection item. In this implementation, the second sample dispensing assembly 120 can use the calibration data obtained by the first sample dispensing assembly 110 performing the project calibration procedure when performing the second detection procedure, so that one sample detection item does not need to perform the project calibration procedure for both the first sample dispensing assembly 110 and the second sample dispensing assembly 120, but only needs to perform the project calibration procedure for one of the first sample dispensing assembly 110 and the second sample dispensing assembly 120.

[0098] As an implementation, the sample analyzer 10 pre-stores preset conditions, which at least include one of the following: a preset time length since the last execution of the item calibration process; a preset time point of a preset maintenance period; information of a newly loaded reagent container; information of a failed quality control detection result; and the controller 400 is further configured to execute the item calibration process when the preset conditions are met. When the sample analyzer 10 pre-stores at least two of the above preset conditions, the item calibration process is executed as long as any one of the preset conditions is met. The preset time length since the last execution of the item calibration process specifically refers to that after the completion of the execution of the item calibration process, the execution of the item calibration process is performed every preset time length. The preset time point of the preset maintenance period specifically refers to that the execution of the item calibration process is performed at a fixed time point, which is not associated with the interval time length of the last execution of the item calibration process. The information of the newly loaded reagent container can be obtained after the sample analyzer 10 is installed for the first time in a specific application, or after the reagent container is replaced after the sample analyzer 10 is used for a period of time. In this embodiment, the item calibration process is not performed during the execution of the sample detection item, which does not occupy the normal sample detection time of the sample analyzer 10, and is automatically executed according to the set program when the preset conditions are met, which is beneficial to make the operation personnel basically unaware of the execution of the item calibration process, and greatly reduces the interference of the item calibration process on the operation personnel.

[0099] As an implementation, the execution period of the item calibration process is 28 days, that is, the preset maintenance period or the preset time length is 28 days. When the reagent of a certain detection item is replaced, the item calibration process of the detection item is executed. When the quality control result of a certain detection item is wrong, the item calibration process of the detection item is executed.

[0100] As an implementation, the calibration data (including but not limited to the first calibration data) contains a plurality of sets of corresponding relationships between different known detection information and different calibration parameters. The calibration data can be a parameter of a linear function, or a calibration curve of a linear function, or a calibration database or table formed by a plurality of sets of known detection information and calibration parameters.

[0101] As an implementation, the controller 400 is further configured to execute a quality control process, which can be executed once a day, for example, once before sample detection in the morning every day; or the quality control process can be executed twice a day, for example, once before sample detection in the morning and once before sample detection in the afternoon.

[0102] As an implementation, the sample analyzer 10 described above is an immunoassay analyzer. The immunoassay analyzer is used to detect immune-related parameters of a blood sample. Prior to the present application, the related art immunoassay analyzer either uses a single needle system to perform sample dispensing of all samples of the immunoassay analyzer, or uses a multi-needle system to perform sample dispensing of different detection items respectively, or uses a multi-needle system to perform sample dispensing of different samples respectively, which requires separate clinical item calibration. These solutions cannot meet the design requirements of the immunoassay analyzer for high detection efficiency, low calibration cost, and high calibration efficiency. In the immunoassay analyzer provided in the present embodiment, the first sample needle 111 and the second sample needle 121 can be used to detect the same detection item and do not need to be calibrated for the same detection item. In this way, on the one hand, the parallel work of the first sample needle 111 and the second sample needle 121 can improve the efficiency of immune detection. On the other hand, since the first sample needle 111 and the second sample needle 121 do not need to be calibrated for the same detection item, the multi-needle calibration cost of the immunoassay analyzer is reduced, and the calibration efficiency is improved. Of course, in specific applications, the type of the sample analyzer 10 is not limited to this. For example, as an alternative implementation, the sample analyzer 10 can also be a biochemical analyzer or a routine blood cell analyzer or a coagulation analyzer, etc. That is, the high-efficiency, low-cost multi-needle system of the present embodiment can be used not only in the immunoassay analyzer, but also in the biochemical analyzer or the routine blood cell analyzer or the coagulation analyzer and other analyzers.

[0103] As an implementation, the detection items performed by the immunoassay analyzer include at least an immunoassay luminescence detection item. The goal of the immunoassay luminescence detection is to detect the content of a certain specific antigen or antibody in the sample. The reaction container is used to carry out the antigen and antibody binding reaction of the sample and the reagent. The detection device 300 is used to detect the light signal of the to-be-detected liquid. Since there are various impurities in the sample, some impurities, such as endogenous enzymes contained in the blood sample, will affect the final detection system (i.e., the to-be-detected liquid to be finally detected), thereby affecting the accuracy of the detection result. Therefore, the execution process of the immunoassay luminescence detection needs to be purified for the target antigen or the target antibody, and then the level (i.e., the content) of the target antigen or the target antibody in the sample is obtained through the luminescence detection of the marker. In order to detect the level of the target antigen or the target antibody in the sample, the present embodiment converts the concentration of the target antigen or the target antibody into a physical quantity of luminescence. Since the antigen or the antibody itself does not have the ability to emit light, the conversion of light emission can be performed through the antibody with a luminescent marker or the antibody with a luminescent marker.

[0104] As an embodiment, the reaction container is used at least to provide a reaction site for the sample and the reagent, so that the target antigen in the sample and the antibody in the reagent or the target antibody in the sample and the antigen in the reagent are combined to form a first reaction solution containing at least a first antigen-antibody complex by generating an antigen-antibody binding reaction. In this embodiment, the target of at least one sample detection item is to detect the content of the target antigen (a certain specific antigen) or the target antibody (a certain specific antibody) in the sample. When the target of one sample detection item is to detect the target antigen in the sample, the sample contains the target antigen and the reagent contains the antibody, and the first antigen-antibody complex is formed by the target antigen in the sample and the antibody in the reagent through the antigen-antibody binding reaction. When the target of one sample detection item is to detect the target antibody in the sample, the sample contains the target antibody and the reagent contains the antibody, and the first antigen-antibody complex is formed by the target antibody in the sample and the antigen in the reagent through the antigen-antibody binding reaction.

[0105] In the fully automatic immune analyzer, the sample needle is responsible for completing the dispensing work of the sample to be tested. For a fully automatic immune analyzer containing two sample needles, consistent sample adding performance is required between the two sample needles. The measurement and evaluation of the difference in sample adding performance of the double sample needles is the basis for the consistency control of the double sample needles. In the double sample needle system, the consistency of the double sample needles is controlled, that is, when the double sample needles dispense the same volume of liquid, the difference between the actual volumes of the two sample needles is as small as possible.

[0106] As an embodiment, the first antigen-antibody complex contained in the first reaction solution is formed by sandwiching the antigen and the antibody. For example, if the content of the target antigen in the sample is to be detected, the magnetic bead reagent distributed by the reagent distribution device 200 carries the antibody, the marker reagent is an antibody reagent carrying a luminescent marker, and the target antigen in the sample is sandwiched between the antibody of the magnetic bead reagent and the antibody of the marker reagent. In this scheme, the cell surface of the sample has an antigen, the surface of the magnetic bead has an antibody, and the marker reagent has an antibody. The target antigen in the sample can be specifically combined with the magnetic bead carrying a specific antibody and the antibody carrying a luminescent marker, thereby forming a first antigen-antibody complex of magnetic bead-target antigen-luminescent marker antibody. If the content of the target antibody in the sample is to be detected, the magnetic bead reagent distributed by the reagent distribution device 200 carries the antigen, and the marker reagent is an antigen reagent carrying a luminescent marker, and the target antibody in the sample is sandwiched between the antigen of the magnetic bead reagent and the antigen of the marker reagent.

[0107] As an embodiment, when the target antigen in the sample needs to be detected, the sandwich method immunoluminescence detection process includes: in the initial mixing process of the sample and the reagent, the target antigen is first combined with the magnetic beads with specific antibodies, and then the target antigen is specifically combined with the antibody with luminescent markers in the reagent, at this time, the magnetic bead antibody-target antigen-luminescent marker antibody system (i.e. the first antigen antibody combination mentioned above) is generated. After the magnetic bead antibody-target antigen-luminescent marker antibody system is generated, the magnetic separation and cleaning operation step is entered. Before the magnetic separation and cleaning operation step, the reaction system contains impurities, and the magnetic separation and cleaning operation can clean away the impurities through liquid exchange and re-dispersion, while retaining the target antigen to be detected in the reaction container, thereby realizing the purification of the reaction liquid. Finally, the second reaction liquid after purification is mixed with the luminescent substrate reagent, which emits light under the catalysis of the luminescent marker, and is collected and counted by the sample detection device 300 (such as a luminometer, etc.). The controller 400 calculates the concentration value of the corresponding target antigen according to the data fed back by the sample detection device 300, so as to obtain the target antigen level of the corresponding sample, thereby helping to make clinical judgments.

[0108] Of course, in specific applications, the antigen-antibody combination contained in the first reaction liquid is not limited to being formed by the antigen and the antibody combined by the sandwich method. In alternative embodiments, the antigen-antibody combination contained in the first reaction liquid can also be formed by the antigen and the antibody combined by the competition method. In this alternative, the antigen-antibody combination contained in the first reaction liquid includes: the first antigen-antibody combination formed by the target antigen in the sample and the antibody on the surface of the magnetic beads in the magnetic bead reagent, and the second antigen-antibody combination formed by the antigen in the marker reagent and the antibody on the surface of the magnetic beads in the magnetic bead reagent. Because the number of antibodies on the magnetic beads is limited, the target antigen in the sample and the antigen in the marker reagent form a competitive relationship, i.e. the luminescence value is inversely proportional to the concentration of the target in the sample. By measuring the luminescence value, the concentration of the target antigen in the sample can be inversely calculated.

[0109] As an embodiment, the execution process of one detection item in the immunoassay instrument includes: adding the sample, adding the magnetic bead reagent and the marker reagent to form the first mixed liquid, mixing and incubating the first mixed liquid to obtain the first reaction liquid, performing magnetic separation and cleaning on the first reaction liquid to obtain the second reaction liquid, adding the luminescent substrate reagent to the second reaction liquid to obtain the second mixed liquid, mixing and incubating the second mixed liquid to obtain the test liquid, and performing optical measurement on the test liquid to obtain the detection result.

[0110] As an embodiment, the marker reagent is an alkaline phosphatase solution. In the enzyme emission system, the final emission is the chemiluminescence generated by the alkaline phosphatase-labeled antigen or antibody and the magnetic bead coating catalyzing the luminescent substrate reagent. The essence is that the alkaline phosphatase catalyzes the luminescent substrate reagent to emit light. Therefore, the alkaline phosphatase is directly mixed with an excess of luminescent substrate reagent to react. The final emission intensity is positively correlated with the amount of alkaline phosphatase added. When a certain concentration of alkaline phosphatase solution is used, the final emission intensity is positively correlated with the volume of the alkaline phosphatase solution.

[0111] As an embodiment, the implementation of evaluating the volume difference of liquid dispensed by the double-sample needle is as follows: in the immunoassay instrument, the two sample needles are controlled to dispense the same volume of alkaline phosphatase solution into the same amount of excess luminescent substrate reagent under the same working condition. After incubation for a certain time to ensure that the alkaline phosphatase solution and the luminescent substrate reagent are fully reacted, the photometer of the immunoassay instrument is used to measure the light of the two reaction liquids, and the emission intensity of the two reaction liquids obtained by the reaction of the alkaline phosphatase solution and the luminescent substrate reagent dispensed by the two sample needles is obtained. Then, combined with the quantitative relationship between the liquid volume dispensed by the sample needle and the emission value in the enzyme+substrate emission system, the difference in the actual liquid volume dispensed by the two sample needles is calculated. The quantitative relationship between the liquid volume dispensed by the sample needle and the emission value is the key to this method. In the enzyme+substrate reaction system, the sample delivery coefficient can be defined to reflect the quantitative relationship between the deviation of the liquid volume dispensed by the sample needle and the deviation of the final emission value: sample delivery coefficient = relative deviation of emission value / relative deviation of sample needle liquid dispensing volume, wherein the relative deviation of sample needle liquid dispensing volume is the difference in the liquid dispensing volume of the same volume of liquid dispensed by the two sample needles (i.e., the first sample needle 111 and the second sample needle 121), and the relative deviation of the emission value is the difference in the emission intensity of the two reaction liquids obtained by the reaction of the liquid dispensed by the two sample needles with the luminescent substrate reagent. The sample delivery coefficient is an inherent attribute of the quantitative relationship between the liquid volume dispensed by the sample needle and the emission value. Within a certain range of dispensing liquid volume, the sample delivery coefficient can be regarded as a constant, and the relative deviation of the sample needle liquid dispensing volume can be calculated as follows: relative deviation of sample needle liquid dispensing volume = relative deviation of emission value / sample delivery coefficient.

[0112] In the immunodetection scene of the sample, there are various sample volumes. Under different sample volumes, the sample dispensing volume deviation of the double-sample needle is different, and the sample delivery coefficient also differs. Therefore, when quantifying the difference between the double-sample needles for sample dispensing volume calibration, the sample calibration process needs to be performed in different calibration volume sections.

[0113] As an implementation, the sample dispensing device 100 is a double-sample needle system, that is, the sample needle of the sample dispensing device 100 only has the first sample needle 111 and the second sample needle 121, which can avoid the phenomenon of too complex structure and too high cost of the sample dispensing device 100 due to too many sample needles while ensuring efficiency. Of course, in specific applications, the sample dispensing device 100 is not limited to a double-sample needle system. For example, in addition to the first sample dispensing assembly 110 and the second sample dispensing assembly 120 described above, the sample dispensing device 100 can also include a third sample dispensing assembly, and the third sample dispensing assembly includes a third sample needle. The first sample needle 111, the second sample needle 121 and the third sample needle are three sample needles that can independently perform sample dispensing actions.

[0114] In this embodiment, the multi-sample needle system ensures the accuracy consistency of the multi-sample needle system by sharing the dispensing power source, thereby ensuring the consistency of the test results of the multi-sample needle system of the multiple sample dispensing systems. One test item can only be calibrated once, and different sample needles can share the same calibration data. Specifically, in this embodiment, when the multi-sample needle system is used to dispense samples, the multi-sample needle system can only perform a project calibration process once before testing the same test item to obtain a calibration data corresponding to the test item, and the multi-sample needle system can share the same calibration data (such as a calibration curve or a function parameter of the calibration curve) obtained by the project calibration process when performing different samples of the test item.

[0115] Embodiment two:

[0116] Referring to FIGS. 1 and 2, Figures 1 to 3 and Figure 6 The sample analyzer 10 provided in this embodiment is mainly different from the sample analyzer 10 of the first embodiment in whether the first sample needle 111 and the second sample needle 121 share the cleaning power source, which is embodied in that in the first embodiment, the first sample needle 111 and the second sample needle 121 share the cleaning power source, while in this embodiment, the first sample needle 111 and the second sample needle 121 do not share the cleaning power source.

[0117] Specifically, in this embodiment, the first cleaning drive component 113 and the second cleaning drive component 123 are two components that independently drive the flow of cleaning fluid. This means that the first sample dispensing assembly 110 and the second sample dispensing assembly 120 do not share a common cleaning fluid power source. The first aspiration power component 112 and the second aspiration power component 122 are the primary factors affecting the difference in dispensing accuracy between the first sample dispensing assembly 110 and the second sample dispensing assembly 120. Therefore, in this embodiment, the first sample dispensing assembly 110 and the second sample dispensing assembly 120 share a common aspiration power component but do not share a cleaning fluid drive component. This also significantly reduces the deviation in sample dispensing accuracy between the first sample dispensing assembly 110 and the second sample dispensing assembly 120.

[0118] As an embodiment, the first sample dispensing assembly 110 further includes a third cleaning control valve 114 and a first liquid path 115. The first liquid path 115 is connected between the first cleaning drive component 113 and the first suction power component 112. The first cleaning drive component 113 is at least used to drive the cleaning liquid from the first cleaning liquid supply device 20 to flow toward the first liquid path 115. The third cleaning control valve 114 is provided on the first liquid path 115 to control the on-off of the first liquid path 115. The second sample dispensing assembly 120 further includes a fourth cleaning control valve 124 and a second liquid path 125. The second liquid path 125 is connected between the second cleaning drive component 123 and the first suction power component 112. The second cleaning drive component 123 is at least used to drive the cleaning liquid from the first cleaning liquid supply device 20 to flow toward the second liquid path 125. The fourth cleaning control valve 124 is provided on the second liquid path 125 to control the on-off of the second liquid path 125. Third purge control valve 114 and fourth purge control valve 124 are two components that independently control the flow of liquid. First liquid path 115 and second liquid path 125 are two parallel liquid paths. In this embodiment, first sample dispensing assembly 110 and second sample dispensing assembly 120 do not share a common purge liquid power source, nor do they share common purge control valves or purge liquid paths.

[0119] In addition to the above, other parts of the sample analyzer 10 provided in this embodiment can refer to the first embodiment and will not be described in detail here.

[0120] Example 3:

[0121] The sample analyzer 10 provided in this embodiment differs from that in the first embodiment primarily in the different configurations of the reagent system, reaction system, and detection system. Specifically, in the first embodiment, the first detection process and the second detection process share the same reagent system, reaction system, and detection system; whereas in this embodiment, the first detection process and the second detection process do not share at least one of the reagent system, reaction system, and detection system.

[0122] Specifically, in the present embodiment, the at least one device used in the first detection process and the second detection process is a device in which two at least partial components can work independently of each other: the reagent dispensing device 200, the reaction device 900, and the detection device 300. In the present embodiment, in the first detection process and the second detection process, in addition to the sample system, at least partial components of the reagent system, the reaction system, and the detection system can also not be shared, as long as the final detection result deviation is within an acceptable range.

[0123] As an implementation, the at least one device used in the first detection process and the second detection process is a device in which two at least partial components can work independently of each other and have calibration parameters for calibration: the reagent dispensing device 200, the reaction device 900, and the detection device 300. In the present embodiment, for the inconsistent components in the reagent system, the reaction system, and the detection system, a correction parameter identification code can be used to make the performance of the inconsistent components in the reagent system, the reaction system, and the detection system consistent, for example, a component has an identification code, when the component is loaded into the sample analyzer 10, the correction parameter of the component can be obtained by scanning the code, and the component is corrected according to the correction parameter of the component, without the need to perform a calibration process on the whole machine. In the present embodiment, the sample system and the reagent system, the reaction system, and the detection system are respectively corrected to meet the consistency requirement; of course, in specific applications, as an alternative implementation, the sample dispensing amount of the first sample dispensing assembly 110 and the second sample dispensing assembly 120 can also be allowed to be inconsistent, but the detection result consistency can be met by correction of at least one of the reagent system, the reaction system, the detection system, for example, by synchronously correcting the reagent system and / or the reaction system to correct the detection result deviation caused by the inconsistent sample dispensing amount, so as to ensure the consistency of the detection result.

[0124] As an implementation, the reagent dispensing device 200 includes at least two reagent dispensing assemblies that can independently perform reagent dispensing actions and are associated with calibration parameters; and / or, the sample analyzer 10 further includes a reaction device 900, which is used to load a reaction container to perform an incubation action of incubating a liquid containing at least a sample and a reagent; the reaction device 900 includes at least two incubation assemblies that can independently perform incubation actions and are associated with calibration parameters; and / or, the detection device 300 includes at least two detection assemblies that can independently perform detection on a to-be-detected liquid and are associated with calibration parameters.

[0125] As an implementation, the reagent dispensing device 200 comprises a first reagent dispensing assembly 210 and a second reagent dispensing assembly 220, the first reagent dispensing assembly 210 comprises a first reagent needle and a first reagent dispensing power component, the first reagent dispensing power component is used to drive the first reagent needle to suck reagent from a reagent container and drive the first reagent needle to dispense at least part of the sucked reagent into a reaction container, the second reagent dispensing assembly 220 comprises a second reagent needle and a second reagent dispensing power component, the second reagent dispensing power component is used to drive the second reagent needle to suck reagent from a reagent container and drive the second reagent needle to dispense at least part of the sucked reagent into a reaction container; the reaction device 900 comprises a first reaction disc and a second reaction disc, the first reaction disc and the second reaction disc are respectively used to carry a reaction container for incubating a sample and a reagent. The detection device 300 comprises a first light receiving component and a second light receiving component, the first light receiving component is used to perform optical detection on the to-be-detected liquid in the reaction container after incubation by the first reaction disc, and the second light receiving component is used to perform optical detection on the to-be-detected liquid in the reaction container after incubation by the second reaction disc. The deviation of the reagent dispensing accuracy of the first reagent dispensing assembly 210 and the reagent dispensing accuracy of the second reagent dispensing assembly 220 is less than or equal to a second preset value; the deviation of the incubation accuracy of the first reaction disc and the incubation accuracy of the second reaction disc is less than or equal to a third preset value; and the deviation of the light measurement accuracy of the first light receiving component and the light measurement accuracy of the second light receiving component is less than or equal to a fourth preset value. In this implementation, the first reagent dispensing assembly 210 and the second reagent dispensing assembly 220 can work in parallel, the first reaction disc and the second reaction disc can work in parallel, and the first light receiving component and the second light receiving component can work in parallel.

[0126] As an implementation, at least one of the following devices used in the first detection process and the second detection process is two devices that can work independently at least in part and have calibration parameters for calibration: the magnetic separation device 500 and the substrate dispensing device 101, that is, the first detection process and the second detection process can also not share the magnetic separation system and / or the substrate dispensing system.

[0127] As an implementation, for inconsistent components in the magnetic separation system and the substrate dispensing system, a calibration parameter correction method (for example, a method similar to partial component calibration parameter identification coding) can be used to make the performance of the shared parts of the magnetic separation system and the substrate dispensing system consistent.

[0128] In addition to the above differences, other parts of the sample analyzer 10 provided in this embodiment can refer to Embodiment One and Embodiment Two, which will not be described in detail here.

[0129] Embodiment Four:

[0130] Reference Figures 1 to 3 and Figure 7As shown, the sample analyzer 10 provided in the embodiment differs from the sample analyzer 10 provided in the first embodiment mainly in that the multi-needle system is used to dispense different target liquids, which is embodied in that, in the first embodiment, the multi-needle system is used to dispense samples, while in the present embodiment, the multi-needle system is used to dispense reagents.

[0131] Specifically, the sample analyzer 10 provided in the embodiment includes a sample dispensing device 100, a reagent dispensing device 200, and a detection device 300. The sample dispensing device 100 is configured to perform a sample dispensing action of drawing a sample from a sample container and dispensing at least part of the drawn sample into a reaction container. The reagent dispensing device 200 is configured to perform a reagent dispensing action of drawing a reagent from a reagent container and dispensing at least part of the drawn reagent into the reaction container. The detection device 300 is configured to detect a to-be-tested liquid made of at least the sample dispensed by the sample dispensing device 100 and the reagent dispensed by the reagent dispensing device 200. The reagent dispensing device 200 includes a first reagent dispensing assembly 210 and a second reagent dispensing assembly 220. The first reagent dispensing assembly 210 includes a first reagent needle and a third dispensing power component, and the third dispensing power component is configured to provide driving force for the first reagent needle to perform a dispensing action. The second reagent dispensing assembly 220 includes a second reagent needle and a fourth dispensing power component, and the fourth dispensing power component is configured to provide driving force for the second reagent needle to perform a dispensing action. The first reagent needle and the second reagent needle are two reagent needles capable of independently performing a reagent dispensing action. The third dispensing power component and the fourth dispensing power component are the same dispensing power component. In the present embodiment, the first reagent needle and the second reagent needle can be used to perform a reagent dispensing action for the same detection item. When batch detection for a certain detection item is required, the first reagent needle can be controlled to perform a reagent dispensing action for a part of the detection item, the second reagent needle can be controlled to perform a reagent dispensing action for another part of the detection item, and the first reagent needle and the second reagent needle can be controlled to work simultaneously or alternately, so that the first reagent needle and the second reagent needle can be fully utilized to improve the detection efficiency of the sample analyzer 10. In addition, since the first reagent needle and the second reagent needle share the dispensing power source, the difference in hardware between the first reagent dispensing assembly 210 and the second reagent dispensing assembly 220 can be reduced, thereby reducing the difference in the amount of reagent dispensed by the first reagent dispensing assembly 210 and the second reagent dispensing assembly 220.

[0132] As an implementation, the controller 400 is configured to control the first reagent dispensing assembly 210 and the second reagent dispensing assembly 220 to respectively perform a reagent dispensing action for the same detection item of two samples.

[0133] As an implementation, the sample analyzer 10 further comprises a reaction device 900, a magnetic separation device 500, a substrate dispensing device 101 and a controller 400; the reagent dispensing device 200 performs a reagent dispensing action, which comprises: aspirating the magnetic bead reagent from the first reagent container and dispensing it into the reaction container, and aspirating the label reagent from the second reagent container and dispensing it into the reaction container; the reaction device 900 is used to carry the reaction container to perform an incubation action, which comprises: incubating the liquid containing at least the sample, the magnetic bead reagent and the label reagent to prepare a first reaction liquid; the magnetic separation device 500 is used to perform a magnetic separation and washing operation on the first reaction liquid to prepare a second reaction liquid; the substrate dispensing device 101 is used to perform a substrate dispensing action, which comprises: aspirating the luminescent substrate reagent from the substrate reagent container, and dispensing at least part of the aspirated luminescent substrate reagent into the reaction container loaded with the second reaction liquid to prepare a fourth reaction liquid with the luminescent substrate reagent; the detection device 300 is used to perform a detection action, which comprises: detecting the luminescent intensity of the fourth reaction liquid; and the controller 400 is configured to: control the same sample dispensing device 100 to perform a sample dispensing action of the same detection item of two samples, respectively, control the first reagent dispensing assembly 210 and the second reagent dispensing assembly 220 to perform a reagent dispensing action of the same detection item of the two samples, respectively, control the same reaction device 900 to perform an incubation action of the same detection item of the two samples, respectively, control the same magnetic separation device 500 to perform a magnetic separation and washing operation of the same detection item of the two samples, respectively, control the same substrate dispensing device 101 to perform a substrate dispensing action of the same detection item of the two samples, respectively, and control the same detection device 300 to perform a detection action of the same detection item of the two samples, respectively.

[0134] As an implementation, the first reagent dispensing assembly 210 further comprises a third washing driving component, which is used to drive the washing liquid from the second washing liquid supply device to flush the first reagent needle; the second reagent dispensing assembly 220 further comprises a fourth washing driving component, which is used to drive the washing liquid from the second washing liquid supply device to flush the second reagent needle; the sample analyzer 10 further comprises a controller 400, which is configured to: when the third suction and injection power component is controlled to drive the first reagent needle to perform a reagent dispensing action, the fourth washing driving component is controlled to drive the washing liquid to flush the second reagent needle; and / or when the fourth suction and injection power component is controlled to drive the second reagent needle to perform a reagent dispensing action, the fourth washing driving component is controlled to drive the washing liquid to flush the first reagent needle.

[0135] In addition to the above differences, the other parts of the sample analyzer 10 provided by the present embodiment can refer to Embodiments 1 to 3, which will not be described in detail here.

[0136] Embodiment Five:

[0137] The sample analyzer 10 provided by the embodiment is mainly different from the sample analyzer 1 in that the multi-needle system is used for dispensing different target liquids, specifically, in the sample analyzer 1, the multi-needle system is used for dispensing samples; and in the sample analyzer 10, the multi-needle system is used for dispensing samples and reagents.

[0138] Specifically, the sample analyzer 10 provided by the embodiment includes a pipetting device and a detection device 300. The pipetting device is used to perform the following liquid dispensing actions: sucking samples from a sample container and dispensing at least part of the sucked samples into a reaction container; and sucking reagents from a reagent container and dispensing at least part of the sucked reagents into the reaction container. The detection device 300 is used to detect a to-be-tested liquid made of at least the samples and the reagents dispensed by the pipetting device. The pipetting device includes a first pipetting assembly and a second pipetting assembly. The first pipetting assembly includes a first pipetting needle and a first pipetting power source, and the first pipetting power source is used to provide driving force for the first pipetting needle to perform a dispensing action. The second pipetting assembly includes a second pipetting needle and a second pipetting power source, and the second pipetting power source is used to provide driving force for the second pipetting needle to perform a dispensing action. The first pipetting needle and the second pipetting needle are two pipetting needles that can independently perform reagent dispensing actions. The first pipetting power source and the second pipetting power source are the same pipetting power source.

[0139] In the embodiment, the first pipetting needle is used for dispensing samples and reagents, and the second pipetting needle is also used for dispensing samples and reagents. The first pipetting needle and the second pipetting needle can be used to perform sample dispensing actions and reagent dispensing actions of the same detection item. When batch detection of a certain detection item is required, the first pipetting needle can be controlled to perform sample dispensing actions and reagent dispensing actions of a part of the detection items, and the second pipetting needle can be controlled to perform sample dispensing actions and reagent dispensing actions of another part of the detection items, so that the first pipetting needle and the second pipetting needle can be fully utilized to improve the detection efficiency of the sample analyzer 10. In addition, since the first pipetting assembly and the second pipetting assembly share the pipetting power source, the difference in hardware between the first pipetting assembly and the second pipetting assembly can be reduced, thereby facilitating the reduction of the difference in sample dispensing amount and the difference in reagent dispensing amount between the first pipetting assembly and the second pipetting assembly.

[0140] As an implementation, the sample analyzer 10 further comprises a reaction device 900, a magnetic separation device 500, a substrate dispensing device 101 and a controller 400; the pipetting device aspirates reagents from the reagent containers and dispenses at least part of the aspirated reagents into the reaction container, including: aspirating magnetic bead reagents from the first reagent container and dispensing into the reaction container, aspirating marker reagents from the second reagent container and dispensing into the reaction container; the reaction device 900 is used to carry the reaction container to perform the following incubation actions: incubating the liquid containing at least the sample, the magnetic bead reagent and the marker reagent to make a first reaction liquid; the magnetic separation device 500 is used to perform a magnetic separation and washing operation on the first reaction liquid to make a second reaction liquid; the substrate dispensing device 101 is used to perform the following substrate dispensing action: aspirating the luminescent substrate reagent from the substrate reagent container and dispensing at least part of the aspirated luminescent substrate reagent into the reaction container loaded with the second reaction liquid to make a fourth reaction liquid with the luminescent substrate reagent; the detection device 300 is used to perform the following detection action: detecting the luminescent intensity of the test liquid; the controller 400 is configured to: control the first pipetting assembly and the second pipetting assembly to respectively perform the liquid dispensing action of the same detection item of the two samples, control the same reaction device 900 to respectively perform the incubation action of the same detection item of the two samples, control the same magnetic separation device 500 to respectively perform the magnetic separation and washing operation of the same detection item of the two samples, control the same substrate dispensing device 101 to respectively perform the substrate dispensing action of the same detection item of the two samples, and control the same detection device 300 to respectively perform the detection action of the same detection item of the two samples.

[0141] As an implementation, the first pipetting assembly further comprises a fifth cleaning driving component, the fifth cleaning driving component is used to at least drive the cleaning liquid from the third cleaning liquid supply device to flush the first pipetting needle; the second pipetting assembly further comprises a sixth cleaning driving component, the sixth cleaning driving component is used to at least drive the cleaning liquid from the third cleaning liquid supply device to flush the second pipetting needle; the sample analyzer 10 further comprises a controller 400, the controller 400 is configured to: when controlling the first pipetting power source to drive the first pipetting needle to perform the liquid dispensing action, control the sixth cleaning driving component to drive the cleaning liquid to flush the second pipetting needle; and / or, when controlling the second pipetting power source to drive the second pipetting needle to perform the liquid dispensing action, control the sixth cleaning driving component to drive the cleaning liquid to flush the first pipetting needle.

[0142] In addition to the above differences, other parts of the sample analyzer 10 provided by the present embodiment can refer to embodiments one to three and will not be described in detail here.

[0143] The above merely describes the preferred embodiments of the present application, and is not intended to limit the patent scope of the present application. Any equivalent structural changes made according to the content of the present application specification and drawings, or direct / indirect application in other related technical fields, are included in the patent protection scope of the present application.

Claims

1. A sample analyzer, characterized in that: include: A sample dispensing device, the sample dispensing device is used to perform the following sample dispensing actions: aspirating a sample from a sample container and dispensing at least a portion of the aspirated sample into a reaction container; A reagent dispensing device, the reagent dispensing device is used to perform the following reagent dispensing action: sucking the reagent from the reagent container and dispensing at least part of the sucked reagent into the reaction container; a detection device for detecting a test solution made of at least the sample dispensed by the sample dispensing device and the reagent dispensed by the reagent dispensing device; In which, the sample dispensing device includes a first sample dispensing component and a second sample dispensing component, the first sample dispensing component includes a first sample needle and a first suction power component, the first suction power component is used to provide driving force for the first sample needle to perform the suction action; the second sample dispensing component includes a second sample needle and a second suction power component, the second suction power component is used to provide driving force for the second sample needle to perform the suction action, the first sample needle and the second sample needle are two sample needles that can perform the sample dispensing action independently of each other, and the first suction power component and the second suction power component are the same suction power component.

2. The sample analyzer according to claim 1, wherein: The first sample dispensing assembly further includes a first cleaning drive component, the first cleaning drive component being at least used to drive the cleaning fluid from the first cleaning fluid supply device to flush the first sample needle; The second sample dispensing assembly further includes a second cleaning drive component, the second cleaning drive component being at least used to drive the cleaning fluid from the first cleaning fluid supply device to flush the second sample needle; The sample analyzer also includes a controller, which is configured to: control the second cleaning drive component to drive the cleaning fluid to flush the second sample needle when controlling the first aspiration power component to drive the first sample needle to perform the sample dispensing action; and / or control the first cleaning drive component to drive the cleaning fluid to flush the first sample needle when controlling the second aspiration power component to drive the second sample needle to perform the sample dispensing action.

3. The sample analyzer according to claim 2, wherein: The first sample dispensing assembly further includes a first cleaning control valve and a first loading control valve. The first cleaning control valve is provided between the first cleaning drive component and the first sample needle to control the on-off of the fluid path between the first cleaning drive component and the first sample needle. The first loading control valve is provided between the first aspiration power component and the first sample needle to control the on-off of the fluid path between the first aspiration power component and the first sample needle. The second sample dispensing assembly further includes a second cleaning control valve and a second loading control valve, the second cleaning control valve being provided between the second cleaning drive component and the second sample needle for controlling the on-off of the fluid path between the second cleaning drive component and the second sample needle, and the second loading control valve being provided between the first aspiration power component and the second sample needle for controlling the on-off of the fluid path between the first aspiration power component and the second sample needle; The controller is further configured to: when it is necessary to control the first sample dispensing component to perform the sample dispensing action, control the first cleaning control valve and the second loading control valve to close, control the first loading control valve and the second cleaning control valve to open, control the first suction power component to start and run to drive the first sample needle to perform the sample dispensing action, and control the second cleaning drive component to start and run to drive the cleaning liquid to flush the second sample needle; when it is necessary to control the second sample dispensing component to perform the sample dispensing action, control the second cleaning control valve and the first loading control valve to close, control the second loading control valve and the first cleaning control valve to open, control the second suction power component to start and run to drive the second sample needle to perform the sample dispensing action, and control the first cleaning drive component to start and run to drive the cleaning liquid to flush the first sample needle.

4. The sample analyzer according to claim 2 or 3, wherein: The first sample dispensing component also includes a third cleaning control valve and a first liquid circuit, the first liquid circuit is connected between the first cleaning drive component and the first suction power component, the first cleaning drive component is at least used to drive the cleaning liquid from the first cleaning liquid supply device to flow toward the first liquid circuit, and the third cleaning control valve is arranged on the first liquid circuit to control the on-off of the first liquid circuit; the second sample dispensing component also includes a fourth cleaning control valve and a second liquid circuit, the second liquid circuit is connected between the second cleaning drive component and the first suction power component, the second cleaning drive component is at least used to drive the cleaning liquid from the first cleaning liquid supply device to flow toward the second liquid circuit, and the fourth cleaning control valve is arranged on the second liquid circuit to control the on-off of the second liquid circuit; the first cleaning drive component and the second cleaning drive component are the same component, the third cleaning control valve and the fourth cleaning control valve are the same component, and the first liquid circuit and the second liquid circuit are the same liquid circuit.

5. The sample analyzer according to any one of claims 1 to 3, wherein: The sample analyzer further includes a controller configured to execute the following project calibration process for a first test project: controlling the first sample dispensing assembly to draw a project calibrator from a calibrator container and dispense it into a reaction container, controlling the reagent dispensing device to draw a reagent from a reagent container and dispense it into the reaction container; controlling the detection device to detect a calibration solution in the reaction container made of at least the project calibrator and the reagent, and obtaining first calibration data corresponding to the first test project based on detection information fed back by the detection device; The controller is also configured to execute the following second detection process for the first detection item: control the second sample dispensing component to perform the sample dispensing action, control the reagent dispensing device to perform the reagent dispensing action, control the sample detection device to detect the test liquid made of at least the sample dispensed by the second sample dispensing component and the reagent dispensed by the reagent dispensing device, obtain second detection data based on the detection information fed back by the detection device, and obtain a second detection result based on the second detection data and the first calibration data corresponding to the first detection item.

6. The sample analyzer according to claim 5, wherein: The sample analyzer is pre-stored with preset conditions, which include at least one of the following: a preset time period has elapsed since the last execution of the project calibration process; a preset time point of a preset maintenance cycle has arrived; information about a newly loaded reagent container has been obtained; information about an error in a quality control test result has been obtained; The controller is further configured to: execute the project calibration process when the preset condition is met.

7. The sample analyzer according to any one of claims 1 to 3, wherein: The deviation between the sample dispensing accuracy of the first sample dispensing component and the sample dispensing accuracy of the second sample dispensing component is less than or equal to a first preset value, and the first preset value is greater than or equal to zero and less than or equal to 5%; and / or, The sample analyzer further includes a controller configured to control the first sample dispensing component and the second sample dispensing component to respectively perform the sample dispensing action of the same detection item of two samples.

8. The sample analyzer according to claim 7, wherein: The first preset value is less than or equal to 2%.

9. The sample analyzer according to any one of claims 1 to 3, wherein: The sample analyzer also includes a controller and a reaction device, wherein the reaction device is used to carry the reaction container to perform the following incubation actions: incubating a liquid containing at least a sample and a reagent; the controller is configured to: control the first sample dispensing component and the second sample dispensing component to respectively perform the sample dispensing action of the same detection item of two samples, and control the same reagent dispensing device to respectively perform the reagent dispensing action of the same detection item of the two samples; control the same reaction device to respectively perform the incubation action of the same detection item of the two samples; and control the same detection device to respectively detect the test liquid made of the two samples and the reagent.

10. The sample analyzer according to claim 9, wherein: The reagent dispensing device performs the reagent dispensing action including: drawing a magnetic bead reagent from a first reagent container and dispensing it into a reaction container, and drawing a marker reagent from a second reagent container and dispensing it into a reaction container; The reaction device is used to carry the reaction container to perform the following incubation action: incubating at least the sample, the magnetic bead reagent, and the marker reagent to produce a first reaction solution; The sample analyzer further includes a magnetic separation device and a substrate dispensing device, wherein the magnetic separation device is used to perform a magnetic separation and cleaning operation on the first reaction liquid to produce a second reaction liquid; The substrate dispensing device is used to perform the following substrate dispensing action: aspirating the luminescent substrate reagent from the substrate reagent container, and dispensing at least part of the aspirated luminescent substrate reagent into the reaction container loaded with the second reaction liquid, so that the second reaction liquid and the luminescent substrate reagent are combined to form the test liquid; The detection device is used to detect the luminescence intensity of the liquid to be tested; The controller is further configured to: control the same magnetic separation device to respectively perform the magnetic separation and washing operations for the same detection item of two samples; and control the same substrate dispensing device to respectively perform the substrate dispensing operations for the same detection item of the two samples.

11. The sample analyzer according to any one of claims 1 to 3, wherein: The reagent dispensing device comprises at least two reagent dispensing components which are at least partially capable of performing the reagent dispensing action independently of each other and are calibrated with calibration parameters; and / or, The sample analyzer further comprises a reaction device, the reaction device being used to carry a reaction container and perform the following incubation action: incubating a liquid containing at least a sample and a reagent; the reaction device comprising at least two incubation components which are at least partially capable of performing the incubation action independently of each other and having calibration parameters for calibration; and / or, The detection device comprises at least two detection components which are at least partially capable of detecting the liquid to be tested independently of each other and have calibration parameters for calibration.

12. A sample analyzer, characterized in that: include: A sample dispensing device, the sample dispensing device is used to perform the following sample dispensing actions: aspirating a sample from a sample container and dispensing at least a portion of the aspirated sample into a reaction container; A reagent dispensing device, the reagent dispensing device is used to perform the following reagent dispensing action: sucking the reagent from the reagent container and dispensing at least part of the sucked reagent into the reaction container; a detection device for detecting a test solution made of at least the sample dispensed by the sample dispensing device and the reagent dispensed by the reagent dispensing device; In which, the reagent dispensing device includes a first reagent dispensing component and a second reagent dispensing component, the first reagent dispensing component includes a first reagent needle and a third suction and injection power component, the third suction and injection power component is used to provide driving force for the first reagent needle to perform the suction and injection action; the second reagent dispensing component includes a second reagent needle and a fourth suction and injection power component, the fourth suction and injection power component is used to provide driving force for the second reagent needle to perform the suction and injection action, the first reagent needle and the second reagent needle are two reagent needles that can perform the reagent dispensing action independently of each other, and the third suction and injection power component and the fourth suction and injection power component are the same suction and injection power component.

13. The sample analyzer according to claim 12, wherein: The sample analyzer further includes a reaction device, a magnetic separation device, a substrate dispensing device and a controller; the reagent dispensing device performs the reagent dispensing action including: drawing a magnetic bead reagent from a first reagent container and dispensing it into a reaction container, and drawing a marker reagent from a second reagent container and dispensing it into a reaction container; the reaction device is used to carry the reaction container to perform the following incubation action: incubating a liquid containing at least a sample, the magnetic bead reagent and the marker reagent to prepare a first reaction liquid; the magnetic separation device is used to perform a magnetic separation and cleaning operation on the first reaction liquid to prepare a second reaction liquid; the substrate dispensing device is used to perform the following substrate dispensing action: drawing a luminescent substrate reagent from a substrate reagent container, and dispensing at least part of the drawn luminescent substrate reagent into a reaction container loaded with the second reaction liquid, so that the fourth reaction liquid and the luminescent substrate reagent are mixed. The test liquid is prepared; the detection device is used to perform the following detection actions: detecting the luminescence intensity of the test liquid; the controller is configured to: control the same sample dispensing device to respectively perform the sample dispensing action of the same detection item of two samples, control the first reagent dispensing component and the second reagent dispensing component to respectively perform the reagent dispensing action of the same detection item of the two samples; control the same reaction device to respectively perform the incubation action of the same detection item of the two samples, control the same magnetic separation device to respectively perform the magnetic separation and washing operation of the same detection item of the two samples, control the same substrate dispensing device to respectively perform the substrate dispensing action of the same detection item of the two samples, and control the same detection device to respectively perform the detection action of the same detection item of the two samples; and / or, The first reagent dispensing assembly further includes a third cleaning drive component, which is at least used to drive the cleaning liquid from the second cleaning liquid supply device to flush the first reagent needle; the second reagent dispensing assembly further includes a fourth cleaning drive component, which is at least used to drive the cleaning liquid from the second cleaning liquid supply device to flush the second reagent needle; the sample analyzer further includes a controller, which is configured to: when controlling the third aspiration power component to drive the first reagent needle to perform the reagent dispensing action, control the fourth cleaning drive component to drive the cleaning liquid to flush the second reagent needle; and / or, when controlling the fourth aspiration power component to drive the second reagent needle to perform the reagent dispensing action, control the fourth cleaning drive component to drive the cleaning liquid to flush the first reagent needle.

14. A sample analyzer, characterized in that: include: A pipetting device, the pipetting device being used to perform the following liquid dispensing action: aspirating a sample from a sample container and dispensing at least a portion of the aspirated sample into a reaction container; and drawing the reagent from the reagent container and injecting at least a portion of the drawn reagent into the reaction container; a detection device for detecting a test liquid prepared by at least the sample and reagent dispensed by the pipetting device; In which, the pipetting device includes a first pipetting component and a second pipetting component, the first pipetting component includes a first pipetting needle and a first pipetting power source, the first pipetting power source is used to provide driving force for the first pipetting needle to perform the aspiration action; the second pipetting component includes a second pipetting needle and a second pipetting power source, the second pipetting power source is used to provide driving force for the second pipetting needle to perform the aspiration action, the first pipetting needle and the second pipetting needle are two pipetting needles that can independently perform the reagent dispensing action, and the first pipetting power source and the second pipetting power source are the same pipetting power source.

15. The sample analyzer according to claim 14, wherein: The sample analyzer further comprises a reaction device, a magnetic separation device, a substrate dispensing device and a controller; the pipetting device draws reagents from a reagent container and dispenses at least part of the drawn reagents into the reaction container, including: drawing magnetic bead reagents from a first reagent container and dispensing them into the reaction container, and drawing marker reagents from a second reagent container and dispensing them into the reaction container; the reaction device is used to carry the reaction container and perform the following incubation actions: incubating a liquid containing at least a sample, the magnetic bead reagents and the marker reagents to prepare a first reaction liquid; the magnetic separation device is used to perform a magnetic separation and washing operation on the first reaction liquid to prepare a second reaction liquid; the substrate dispensing device is used to perform the following substrate dispensing actions: drawing luminescent substrate reagents from a substrate reagent container and dispensing at least part of the drawn luminescent substrate reagents into a liquid containing a The second reaction liquid is placed in a reaction container so that the fourth reaction liquid and the luminescent substrate reagent are prepared into the liquid to be tested; the detection device is used to perform the following detection action: detecting the luminescence intensity of the liquid to be tested; the controller is configured to: control the first pipetting component and the second pipetting component to respectively perform the liquid dispensing action of the same detection item of the two samples, control the same reaction device to respectively perform the incubation action of the same detection item of the two samples, control the same magnetic separation device to respectively perform the magnetic separation and washing operation of the same detection item of the two samples, control the same substrate dispensing device to respectively perform the substrate dispensing action of the same detection item of the two samples, and control the same detection device to respectively perform the detection action of the same detection item of the two samples; and / or, The first pipetting assembly also includes a fifth cleaning drive component, which is at least used to drive the cleaning liquid from the third cleaning liquid supply device to flush the first pipetting needle; the second pipetting assembly also includes a sixth cleaning drive component, which is at least used to drive the cleaning liquid from the third cleaning liquid supply device to flush the second pipetting needle; the sample analyzer also includes a controller, which is configured to: when controlling the first pipetting power source to drive the first pipetting needle to perform the liquid dispensing action, control the sixth cleaning drive component to drive the cleaning liquid to flush the second pipetting needle; and / or, when controlling the second pipetting power source to drive the second pipetting needle to perform the liquid dispensing action, control the sixth cleaning drive component to drive the cleaning liquid to flush the first pipetting needle.

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