Materials and methods for mitigating presence of nitrosamines in packaging using activated carbon or derivatives thereof

By filling the top space of drug packaging with activated carbon or its derivatives, the problem of difficult removal of N-nitroso compounds in drug packaging is solved, thereby reducing health risks and meeting regulatory standards.

CN120813331APending Publication Date: 2025-10-17CSP TECHNOLOGIES INC
14 Cites 0 Cited by

Patent Information

Application Number
CN202480013112.2
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Priority Date
2023-09-05
Filing Date
2024-04-01
Publication Date
2025-10-17

AI Technical Summary

Technical Problem

Existing technologies make it difficult to effectively reduce or remove N-nitroso compounds in pharmaceutical and food packaging, leading to increased health risks, and traditional methods may affect the preparation or storage conditions of pharmaceutical compositions.

Method used

A headspace not occupied by a pharmaceutical dosage form is formed in the outer shell of the pharmaceutical package and filled with activated carbon or a derivative thereof to adsorb and reduce or inhibit the formation of N-nitroso compounds.

Benefits of technology

By using activated carbon or its derivatives in the headspace of pharmaceutical packaging, the formation and concentration of N-nitroso compounds can be significantly reduced, meeting government regulatory standards and reducing patient exposure risks.

✦ Generated by Eureka AI based on patent content.
Patent Text Reader

Abstract

Disclosed herein are materials, articles, and methods for reducing, mitigating, or excluding the formation and / or amount of nitrosylating agents and / or N-nitroso compounds, including N-nitrosamines, in a package containing an active agent and a pharmaceutical dosage form in a shell, wherein the active agent can be effective to reduce, mitigate, or exclude the formation and / or amount of nitrosylating agents and / or N-nitroso compounds in the shell and / or in the pharmaceutical dosage form. There is provided a drug delivery system comprising a blister pack configured to contain a plurality of drug dosage forms, the blister pack comprising an active ingredient, the active ingredient may be effective to reduce, mitigate, or exclude the formation and / or amount of nitrosylating agents and / or N-nitroso compounds in the outer shell of the blister pack and / or in the pharmaceutical dosage form.
Need to check novelty before this filing date? Find Prior Art