Sterile sampling device and sampling method

Abstract

The invention relates to the field of pharmaceutical sampling, and discloses a sterile sampling device which comprises a liquid medicine pipe, a sampling mechanism is arranged on the liquid medicine pipe, a first connecting nozzle, a second connecting nozzle and a branch pipe located between the first connecting nozzle and the second connecting nozzle are arranged on the outer circle face of the liquid medicine pipe, and the tail end of the first connecting nozzle is communicated with the sampling mechanism, and a first one-way valve is arranged at the communication position. The tail end of the second connecting nozzle is connected with a side pipe, the tail end of the side pipe is communicated with the sampling mechanism, a second one-way valve is arranged at the communication position, the first one-way valve is used for enabling fluid in the liquid medicine pipe to flow into the sampling mechanism in a one-way mode, and the second one-way valve is used for enabling fluid in the sampling mechanism to flow into the liquid medicine pipe in a one-way mode. One end of the branch pipe is open and is connected with the liquid medicine pipe, the other end of the branch pipe is closed, the valve plug is sleeved with the branch pipe, and the valve plug partially extends into the liquid medicine pipe. According to the scheme, accurate quantification and sterile sampling of the liquid medicine can be achieved, and after sampling is finished, the liquid medicine flowing to the next pharmaceutical procedure does not make contact with the external environment in the whole process.

Description

[0001] The present invention relates to the pharmaceutical field, in particular to the pharmaceutical sampling field, and in particular to an aseptic sampling device and a sampling method. Background Art

[0002] During the manufacturing process of liquid medicine, in order to ensure the quality of the liquid medicine, it is generally necessary to sample and test the liquid medicine. In the existing technology, sampling valve technology is generally used for sampling. Specifically, a valve is set on the medicine tank or the liquid medicine flow pipeline. When sampling, the valve is opened and the liquid medicine can flow out through the valve. After sampling, the valve is closed. This sampling method has some shortcomings. For example, when the liquid medicine flows out through the valve, the flow rate is uncontrollable and the sampling volume is uncontrollable. For example, there are dead corners in the internal structure of the existing valve. When sampling, it is easy for the liquid medicine to remain in the dead corners inside the valve, which is difficult to clean and easy to deteriorate over time. For example, when sampling, the liquid medicine is connected to the outside world, and it is difficult to achieve sterile sampling, which is easy to cause contamination of the liquid medicine in the medicine tank.

[0003] Based on the above, the present invention proposes a sterile sampling device and a sampling method. Summary of the Invention

[0004] To solve the problems mentioned in the above background, the present invention provides a sterile sampling device and a sampling method.

[0005] In order to achieve the above technical objectives, the technical solutions adopted by the present invention are as follows.

[0006] A sterile sampling device includes a medicine liquid tube, which is provided with a sampling mechanism. The outer surface of the medicine liquid tube is provided with a nozzle 1, a nozzle 2 and a branch pipe located between the two. The end of the nozzle 1 is connected to the sampling mechanism and a one-way valve 1 is provided at the connection point. The end of the nozzle 2 is connected to a side tube, and the end of the side tube is connected to the sampling mechanism and a one-way valve 2 is provided at the connection point. The one-way valve 1 is used to allow the fluid in the medicine liquid tube to flow unidirectionally toward the sampling mechanism. The one-way valve 2 is used to allow the fluid in the sampling mechanism to flow unidirectionally toward the medicine liquid tube. One end of the branch pipe is open and connected to the medicine liquid tube, and the other end is closed. A valve plug is sleeved inside the branch pipe, and the valve plug partially extends into the medicine liquid tube.

[0007] Furthermore, a threaded hole is provided at the closed end of the branch pipe, a sliding seat is provided inside the branch pipe, a spring is provided between the valve plug and the sliding seat, and a threaded shaft is installed in the threaded hole.

[0008] Furthermore, the sampling mechanism includes a cylindrical shell 1 and a cylindrical shell 2, the end of the nozzle 1 is connected to the nozzle 3 arranged on the cylindrical shell 1, and the end of the side tube is connected to the nozzle 4 arranged on the cylindrical shell 2.

[0009] Furthermore, a sleeve hole 1 is provided on the cylinder cover of the cylinder shell 1, a sleeve 1 is sleeved in the sleeve hole 1, one end of the sleeve 1 is closed and extends into the cylinder shell 1, and a sampling hole is provided on the outer circumferential surface of the portion of the sleeve 1 extending into the cylinder shell 1; A second sleeve hole is provided on the cylinder cover of the second cylinder shell, and a second sleeve is provided in the second sleeve hole. An external step and an internal bracket are provided at one end of the second sleeve extending into the second cylinder shell. A second spring is provided between the external step and the cylinder cover of the second cylinder shell. A sealed sliding guide is formed between the external step and the second cylinder shell, and the second sleeve and the first sleeve are connected through a connecting pipe.

[0010] Furthermore, a piston is sleeved in the second cylinder shell, a piston hole is opened on the end face of the piston, and a piston rod is sleeved in the piston hole. Initially, the piston rod contacts the inner bracket. The sampling mechanism also includes an air pump for driving the piston and the piston rod to move.

[0011] Furthermore, the air pump includes a pump casing, in which a pump plug is sleeved, a pump plug rod extending from the end of the pump plug, the end of the pump plug rod extending into the barrel casing 2 and connected to the piston, the interior of the pump plug rod is hollow, one end of the piston rod extends into the pump plug rod and forms a sealed sliding guide fit, a spring 3 is installed inside the pump plug rod and is located between the piston rod and the pump plug, a damping assembly is provided between the piston rod and the pump plug rod, and the damping assembly is configured to switch between a no-load state and a damping state.

[0012] Furthermore, a connecting rod is extended from the end of the piston rod extending into the pump plug rod, and a damping groove in the shape of an annular groove is provided on the outer circumference of the connecting rod. The damping assembly includes a mounting hole provided through the outer circumference of the pump plug rod, a collar is provided on the outside of the pump plug rod, a damping block is provided in the mounting hole, a spring 4 is provided between the damping block and the collar, and the end of the damping block extending into the pump plug rod is chamfered at two sides along the axis direction of the pump plug rod; An unlocking rod is installed on the end of the pump piston rod connected to the pump piston, which is slidable along its own axial center line. A spring five is provided between the unlocking rod and the pump piston rod to drive the unlocking rod to move away from the piston rod. A pressure plate is provided after one end of the unlocking rod passes through the pump piston.

[0013] Furthermore, it also includes a sampling chamber, the liquid medicine tube passes through the sampling chamber, the sampling mechanism is located in the sampling chamber, and the sampling chamber is provided with an air inlet valve for steam to enter and an exhaust valve for steam to discharge.

[0014] When the liquid medicine passes through the liquid medicine pipe, a stream will be separated and enter the cylinder shell one through the one-way valve one, and then flow into the cylinder shell two through the sampling hole, sleeve one, connecting pipe and sleeve two in sequence, and then flow back to the liquid medicine pipe through the one-way valve two and the side pipe.

[0015] A sampling method for a sterile sampling device: Step 1: The pump plug moves closer to the second barrel shell. During this movement, the pump plug first moves with the pump plug rod, piston, and piston rod. The movement of the piston rod moves the second sleeve, connecting tube, and the first sleeve together. The second spring is compressed, causing the sampling hole to gradually move away from the first barrel shell. When the compression of the second spring reaches the maximum and the second sleeve cannot move further, the sampling hole is located directly above the test tube. Step 2: The pump plunger continues to move, the piston rod cannot move, the spring 3 is compressed, and the piston continues to move with the pump plunger, pushing the liquid in the sampling mechanism out. The liquid falls into the test tube through the sampling hole. When the piston contacts the sleeve 2, the sampling is completed, and the damping block is inserted into the damping groove. Step 3: The pump plug moves in the opposite direction. During this movement, the pump plug moves with the pump plug rod, piston and piston rod. Spring 2 releases its elastic force to reset sleeve 2, connecting pipe and sleeve 1. When the pressure plate contacts the pump housing, the pump plug continues to move in the opposite direction. The unlocking rod does not move and squeezes the connecting rod to disengage the damping block from the damping groove. Spring 3 releases its elastic force to reset the piston rod.

[0016] Compared with the prior art, the present invention has the following beneficial effects: 1. In this solution, the liquid medicine is separated into one stream, which enters the first cartridge through the one-way valve, then flows into the second cartridge through the sampling hole, the first sleeve, the connecting pipe and the second sleeve in sequence, and then flows back to the liquid medicine pipe through the second one-way valve and the side pipe. Therefore, this solution does not have the problem of residual liquid medicine in dead corners. 2. In this scheme, the amount of liquid medicine obtained by sampling is a fixed value, which can achieve accurate quantitative sampling; 3. In this solution, during the resetting process of the sampling mechanism, the liquid medicine at the sampling hole is similar to the liquid at the end of the syringe needle. Although it will not flow out, there will be a downward bulge, which is in contact with the outside air. When the sampling mechanism is reset, the sleeve and the barrel shell will cooperate to scrape off the protruding liquid medicine bulge. That is to say, after the sampling is completed, the part of the liquid medicine in contact with the outside world will be scraped off, and the liquid medicine flowing to the next pharmaceutical process has no contact with the external environment throughout the process, thus achieving sterile sampling. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 It is a structural schematic diagram of the present invention; Figure 2 It is an internal schematic diagram of the present invention; Figure 3 Cross-section of the liquid medicine tube and sampling mechanism Figure 1 ; Figure 4 Cross-section of the liquid medicine tube and sampling mechanism Figure 2 ; Figure 5 Cross-section of the liquid medicine tube and sampling mechanism Figure 3 ; Figure 6 is a cross-sectional view of the liquid medicine tube; Figure 7 It is a partial cross-sectional view of the sampling mechanism; Figure 8 is a cross-sectional view of the air pump; Figure 9 A cross-sectional view of the damping assembly.

[0018] The reference numerals in the accompanying drawings are: 100, sampling chamber; 101, cover plate; 102, inlet valve; 103, exhaust valve; 200, liquid medicine pipe; 201, branch pipe; 202, valve plug; 203, slide seat; 204, spring 1; 205, threaded shaft; 206, one-way valve 1; 207, side pipe; 208, one-way valve 2; 300, sampling mechanism; 301, cylinder shell 1; 302, sleeve 1; 303, sampling hole ; 304, cylinder shell two; 305, sleeve two; 306, spring two; 307, inner bracket; 308, connecting pipe; 309, pump shell; 310, pump plug; 311, piston; 312, pump plug rod; 313, piston rod; 314, spring three; 315, damping groove; 316, collar; 317, damping block; 318, spring four; 319, unlocking rod; 320, spring five. DETAILED DESCRIPTION

[0019] In order to further illustrate the technical means and effects adopted by the present invention to achieve the predetermined purpose of the invention, the specific implementation methods, structures, features and effects of the present invention are described in detail below in conjunction with the accompanying drawings and preferred embodiments.

[0020] This plan is attached Figure 2 In the figure, a refers to the test tube containing the liquid sample.

[0021] Reference Figure 1-Figure 5 A sterile sampling device includes a liquid medicine tube 200. In the pharmaceutical process, the liquid medicine needs to go through several processes. There is generally a pipeline between two adjacent processes to supply the liquid medicine of the previous process to the next process. In this solution, the liquid medicine tube 200 can be a pipeline between two adjacent processes. This solution is used to sample and test the liquid medicine after completing a certain process.

[0022] The liquid medicine tube 200 is provided with a sampling mechanism 300 , which is used to perform precise, aseptic, and quantitative sampling of the liquid medicine in the liquid medicine tube 200 .

[0023] In a preferred embodiment, a sampling chamber 100 can be set up, and the liquid medicine tube 200 passes through the sampling chamber 100. The sampling mechanism 300 is located in the sampling chamber 100. The sampling chamber 100 is provided with an air inlet valve 102 and an exhaust valve 103. The former is used for steam to enter and the latter is used for steam to discharge. The internal environment of the sampling chamber 100 is disinfected and sterilized by steam sterilization. The significance of this is that when sampling, the cover 101 of the sampling chamber 100 is opened, the test tube is placed directly under the sampling end of the sampling mechanism 300, and the cover 101 is closed. After the sampling is completed, the test tube is removed, so that the entire sampling process takes place in a sterile environment.

[0024] One of the core aspects of this solution is the precise, sterile, and quantitative sampling of the sampling mechanism 300. Specifically: Reference Figure 6 and Figure 7 The sampling mechanism 300 includes a cartridge case 1 301 and a cartridge case 2 304 .

[0025] The outer circumferential surface of the medicine liquid tube 200 is provided with a nozzle 1, a nozzle 2 and a branch pipe 201 located between the nozzle 1 and the nozzle 2, wherein the end of the nozzle 1 is connected to the nozzle 3 provided on the cylinder shell 1 301 and a one-way valve 1 206 is provided at the connection point, the end of the nozzle 2 is connected to the side tube 207, the end of the side tube 207 is connected to the nozzle 4 provided on the cylinder shell 2 304 and a one-way valve 208 is provided at the connection point, the one-way valve 1 206 is used to make the fluid in the medicine liquid tube 200 flow unidirectionally toward the cylinder shell 1 301, and the one-way valve 208 is used to make the flow in the cylinder shell 2 304 flow unidirectionally toward the medicine liquid tube 200.

[0026] One end of the branch pipe 201 is open and connected to the liquid medicine pipe 200, and the other end is closed and has a threaded hole. A valve plug 202 and a slide seat 203 are sleeved inside the branch pipe 201. The valve plug 202 partially extends into the liquid medicine pipe 200. A spring 204 is provided between the valve plug 202 and the slide seat 203. A threaded shaft 205 is threadedly installed in the threaded hole.

[0027] By screwing the threaded shaft 205, the volume of the valve plug 202 extending into the medicine liquid tube 200 can be changed. If the valve plug 202 extends into a larger volume, the flow rate of the medicine liquid through the valve plug 202 will decrease, and then it will push the one-way valve 206 to open it, and the medicine liquid will flow into the cylinder shell 301 through the one-way valve 206. On the contrary, if the valve plug 202 extends into a smaller volume, the medicine liquid will only flow in the medicine liquid tube 200. In this solution, the valve plug 202 extends into a larger volume, which can enable the medicine liquid to not only flow in the medicine liquid tube 200, but also separate a stream to flow to the sampling mechanism 300 and then flow back into the medicine liquid tube 200.

[0028] It should be noted that the valve plug 202 and the branch pipe 201 are in sealed sliding guide cooperation, so no liquid medicine will penetrate into the branch pipe 201 and will not cause any adverse effects on the liquid medicine in the liquid medicine pipe 200 .

[0029] Reference Figure 7 A sleeve hole 1 is provided on the cylinder cover of the cylinder shell 301, and a sleeve 1 302 is provided in the sleeve hole 1. One end of the sleeve 1 302 is closed and extends into the cylinder shell 1 301. A sampling hole 303 is provided on the outer circumferential surface of the part of the sleeve 1 302 extending into the cylinder shell 1 301. The aperture of the sampling hole 303 is relatively small. It is drawn larger in the drawings of this scheme for clarity. Under no pressure conditions, the liquid medicine in the sleeve 1 302 cannot flow out through the sampling hole 303, which is similar to the syringe technology.

[0030] A second sleeve hole is provided on the cylinder cover of the second cylinder shell 304, and a second sleeve 305 is sleeved in the second sleeve hole. An end of the second sleeve 305 extending into the second cylinder shell 304 is provided with an external step and an internal bracket 307. A second spring 306 is provided between the external step and the cylinder cover of the second cylinder shell 304, and a sealed sliding guide is formed between the external step and the second cylinder shell 304.

[0031] The second sleeve 305 and the first sleeve 302 are connected through the connecting pipe 308; a stream of liquid medicine separated from the liquid medicine tube 200 enters the cylindrical shell 1 301 through the one-way valve 1 206, and then flows into the cylindrical shell 2 304 through the sampling hole 303, the first sleeve 302, the connecting pipe 308 and the second sleeve 305 in sequence, and then flows back to the liquid medicine tube 200 through the one-way valve 2 208 and the side pipe 207. It should be noted that since the liquid medicine always flows in the sampling mechanism 300, there will be no dead corner residual liquid medicine in the one-way valve 1 206 and the one-way valve 2 208.

[0032] Reference Figure 3-Figure 5 and Figure 8 A piston 311 is also sleeved in the cylinder shell 304 . The end surface of the piston 311 is provided with a piston hole, and a piston rod 313 is sleeved in the piston hole. Initially, the piston rod 313 is in contact with the inner bracket 307 .

[0033] The sampling mechanism 300 further includes an air pump for driving the piston 311 and the piston rod 313 to move.

[0034] Reference Figure 8 and Figure 9The air pump includes a pump housing 309, in which a pump plug 310 is sleeved. A pump plug rod 312 extends from the end of the pump plug 310. The end of the pump plug rod 312 extends into the cylinder housing 304 and is connected to the piston 311. The interior of the pump plug rod 312 is hollow, and one end of the piston rod 313 extends into the pump plug rod 312 to form a sealed sliding guide fit. A spring 314 is installed inside the pump plug rod 312 and is located between the piston rod 313 and the pump plug 310.

[0035] Furthermore, a damping assembly is provided between the piston rod 313 and the pump plug rod 312, and the damping assembly is configured to switch between a no-load state and a damping state. Initially, it is in a no-load state and no damping is applied to the piston rod 313. When it is in the damping state, damping is applied to the piston rod 313, thereby causing the pump plug rod 312 to move along with the piston rod 313.

[0036] Specifically, refer to Figure 9 The piston rod 313 extends into the end of the pump plug rod 312 and is extended with a connecting rod. The connecting rod and the piston rod 313 can be processed as one piece, and the outer circular surface of the connecting rod is provided with a damping groove 315 in the shape of an annular groove.

[0037] The damping assembly includes a mounting hole that passes through the outer circumferential surface of the pump plug rod 312. A collar 316 is sleeved on the outside of the pump plug rod 312 to seal the opening of the mounting hole. A damping block 317 is sleeved in the mounting hole. A spring 318 is provided between the damping block 317 and the collar 316. The end of the damping block 317 that extends into the pump plug rod 312 is chamfered at two sides along the axial direction of the pump plug rod 312 to form two inclined surfaces.

[0038] An unlocking rod 319 is installed on the end of the pump piston rod 312 connected to the pump piston 310, sliding along its own axial direction. A spring 320 is arranged between the unlocking rod 319 and the pump piston rod 312, and its elastic force is used to drive the unlocking rod 319 to move away from the piston rod 313. A pressure plate is provided after one end of the unlocking rod 319 passes through the pump piston 310.

[0039] Reference Figure 8 Two air nozzles, which are far away from each other, are provided on the pump housing 309. One is located on the side of the pump plug 310 away from the pump plug rod 312, and the other is close to the piston 311. Compressed air enters the pump housing 309 through one air nozzle and drives the air in the pump housing 309 to be discharged from the other air nozzle, thereby causing the pump plug 310 to move in the pump housing 309.

[0040] Working principle of the present invention: When the liquid medicine passes through the liquid medicine tube 200, a stream is separated and enters the cartridge housing 1 301 through the one-way valve 1 206. Then, it flows through the sampling hole 303, the cannula 1 302, the connecting tube 308, and the cannula 2 305 into the cartridge housing 2 304. Then, it flows back to the liquid medicine tube 200 through the one-way valve 208 and the side tube 207. When sampling is required, the cover 101 is opened and the test tube is placed in the sterilized sampling chamber 100. Then, the air pump is started. Specifically: The pump plunger 310 moves closer to the second cartridge case 304. During this movement, the pump plunger 310 first moves with the pump plunger rod 312, piston 311, and piston rod 313. The movement of the piston rod 313 then moves with the second sleeve 305, connecting tube 308, and first sleeve 302. The second spring 306 is compressed, causing the sampling hole 303 to gradually move away from the first cartridge case 301. When the second spring 306 reaches its maximum compression and the second sleeve 305 cannot move further, the sampling hole 303 is located directly above the test tube. At this time, the second one-way valve 208 is separated by the piston 311, and the liquid medicine cannot return to the liquid medicine pipe 200 through the second one-way valve 208. In other words, the liquid medicine in the sampling mechanism 300 remains unchanged at this time, with neither new liquid medicine entering nor liquid medicine flowing out. Afterwards, the pump plunger 310 continues to move, the piston rod 313 cannot move, the spring 314 is compressed, and the piston 311 continues to move with the pump plunger 310. During this process, the liquid medicine in the sampling mechanism 300 is pushed out, similar to the injection action of a syringe. The liquid medicine falls into the test tube through the sampling hole 303. During this process, the damping assembly gradually switches to the damping state. When the piston 311 contacts the sleeve 305, the sampling is completed. At this time, the damping block 317 is inserted into the damping groove 315, and the damping assembly switches to the damping state. Then, the pump plug 310 moves in the opposite direction, that is, it moves away from the second barrel shell 304. During this movement, since the damping assembly switches to the damping state, at the beginning, the pump plug 310 moves with the pump plug rod 312, the piston 311 and the piston rod 313, and the spring 2 306 releases the elastic force to reset the sleeve 2 305, the connecting pipe 308 and the sleeve 1 302. After that, the pump plug 310 continues to move in the opposite direction until the pressure plate contacts the pump shell 309, the unlocking rod 319 moves relative to the connecting rod, and the damping block 317 is disengaged from the damping groove 315. The damping assembly switches to the no-load state, and the spring 314 releases the elastic force to reset the piston rod 313. This time, the sampling mechanism 200 completes the reset.

[0041] In the above process, on the one hand, quantitative sampling can be achieved during the entire sampling process, and on the other hand, there will be no problem of residual liquid medicine in dead corners. In addition, during the resetting process of the sampling mechanism 200, the liquid medicine at the sampling hole 303 is similar to the liquid in the syringe. Although it will not flow out, there will be a downward protrusion, which is in contact with the outside air. When the sampling mechanism 200 is reset, the sleeve 302 cooperates with the cylinder shell 301 to scrape off the protruding liquid medicine protrusion. That is to say, after the sampling is completed, the part of the liquid medicine in contact with the outside world will be scraped off, and the liquid medicine flowing to the next pharmaceutical process has no contact with the external environment throughout the process, thereby achieving the purpose of sterile sampling.

[0042] The above description is merely a preferred embodiment of the present invention and does not constitute any form of limitation to the present invention. Although the present invention has been disclosed as above in terms of a preferred embodiment, it is not intended to limit the present invention. Any person skilled in the art can, without departing from the scope of the technical solution of the present invention, make some changes or modifications to equivalent embodiments using the technical contents disclosed above. However, any brief modifications, equivalent changes and modifications made to the above embodiments based on the technical essence of the present invention without departing from the content of the technical solution of the present invention are still within the scope of the technical solution of the present invention.

Claims

1. A sterile sampling device, comprising a liquid medicine tube (200), characterized in that: A sampling mechanism (300) is provided on the liquid medicine tube (200). The outer circumferential surface of the liquid medicine tube (200) is provided with a nozzle 1, a nozzle 2, and a branch pipe (201) located between the nozzle 1 and the branch pipe (201). The end of the nozzle 1 is connected to the sampling mechanism (300) and a one-way valve 1 (206) is provided at the connection point. The end of the nozzle 2 is connected to a side tube (207). The end of the side tube (207) is connected to the sampling mechanism (300) and a one-way valve 2 (208) is provided at the connection point. One-way valve 1 (206) is used to allow the fluid in the liquid medicine tube (200) to flow in one direction toward the sampling mechanism (300), and one-way valve 2 (208) is used to allow the fluid in the sampling mechanism (300) to flow in one direction toward the liquid medicine tube (200). One end of the branch pipe (201) is open and connected to the liquid medicine tube (200), and the other end is closed. A valve plug (202) is provided inside the branch pipe (201), and the valve plug (202) partially extends into the liquid medicine tube (200).

2. A sterile sampling device according to claim 1, characterized in that: A threaded hole is provided at the closed end of the branch pipe (201), a sliding seat (203) is provided inside the branch pipe (201), a spring (204) is provided between the valve plug (202) and the sliding seat (203), and a threaded shaft (205) is installed in the threaded hole.

3. A sterile sampling device according to claim 1, characterized in that: The sampling mechanism (300) includes a cylindrical shell (301) and a cylindrical shell (304). The end of the nozzle (1) is connected to the nozzle (3) provided on the cylindrical shell (301). The end of the side tube (207) is connected to the nozzle (4) provided on the cylindrical shell (304).

4. A sterile sampling device according to claim 3, characterized in that: A sleeve hole 1 is provided on the cylinder cover of the cylinder shell 1 (301), a sleeve pipe 1 (302) is sleeved in the sleeve hole 1, one end of the sleeve pipe 1 (302) is closed and extends into the cylinder shell 1 (301), and a sampling hole (303) is provided on the outer circumferential surface of the portion of the sleeve pipe 1 (302) extending into the cylinder shell 1 (301); The cover of the second cylindrical shell (304) is provided with a second sleeve hole, and the second sleeve hole is provided with a second sleeve (305). The end of the second sleeve (305) extending into the second cylindrical shell (304) is provided with an external step and an internal bracket (307). A second spring (306) is provided between the external step and the cover of the second cylindrical shell (304). A sealed sliding guide is formed between the external step and the second cylindrical shell (304). The second sleeve (305) and the first sleeve (302) are connected through a connecting pipe (308).

5. A sterile sampling device according to claim 4, characterized in that: A piston (311) is also sleeved in the second cylinder shell (304), and a piston hole is opened on the end surface of the piston (311). A piston rod (313) is sleeved in the piston hole. Initially, the piston rod (313) contacts the inner bracket (307). The sampling mechanism (300) also includes an air pump for driving the piston (311) and the piston rod (313) to move.

6. A sterile sampling device according to claim 5, characterized in that: The air pump includes a pump housing (309), a pump plug (310) is sleeved in the pump housing (309), a pump plug rod (312) extends from the end of the pump plug (310), the end of the pump plug rod (312) extends into the second cylinder housing (304) and is connected to the piston (311), the interior of the pump plug rod (312) is hollow, one end of the piston rod (313) extends into the pump plug rod (312) and forms a sealed sliding guide fit, a spring (314) is installed inside the pump plug rod (312) and is located between the piston rod (313) and the pump plug (310), a damping component is provided between the piston rod (313) and the pump plug rod (312), and the damping component is configured to switch between a no-load state and a damping state.

7. A sterile sampling device according to claim 6, characterized in that: A connecting rod is extended from the end of the piston rod (313) extending into the pump plug rod (312), and a damping groove (315) in the shape of an annular groove is provided on the outer circumferential surface of the connecting rod. The damping assembly includes a mounting hole penetrating the outer circumferential surface of the pump plug rod (312), a collar (316) is sleeved on the outside of the pump plug rod (312), a damping block (317) is sleeved in the mounting hole, a spring (318) is provided between the damping block (317) and the collar (316), and the end of the damping block (317) extending into the pump plug rod (312) is chamfered at two sides along the axis direction of the pump plug rod (312); An unlocking rod (319) is slidably mounted on the end portion of the pump plug rod (312) connected to the pump plug (310) along its own axial centerline direction. A spring (320) is provided between the unlocking rod (319) and the pump plug rod (312) for driving the unlocking rod (319) to move away from the piston rod (313). A pressure plate is provided after one end of the unlocking rod (319) passes through the pump plug (310).

8. A sterile sampling device according to claim 1 or 7, characterized in that: The device further comprises a sampling chamber (100), a liquid medicine tube (200) passing through the sampling chamber (100), a sampling mechanism (300) located in the sampling chamber (100), and an air inlet valve (102) for steam entry and an air exhaust valve (103) for steam exhaust.

9. The sampling method of a sterile sampling device according to claim 7, characterized in that: When the liquid medicine passes through the liquid medicine tube (200), a stream is separated and enters the barrel shell (301) through the one-way valve (206). Then, it flows into the barrel shell (304) through the sampling hole (303), the sleeve (302), the connecting pipe (308) and the sleeve (305) in sequence, and then flows back to the liquid medicine tube (200) through the one-way valve (208) and the side pipe (207). The sampling process of the sampling mechanism (200) includes the following steps: Step 1: The pump plug (310) moves closer to the second shell (304). During this movement, the pump plug (310) first moves with the pump plug rod (312), the piston (311) and the piston rod (313). The movement of the piston rod (313) moves with the second sleeve (305), the connecting tube (308) and the first sleeve (302). The second spring (306) is compressed, so that the sampling hole (303) gradually leaves the first shell (301). When the compression of the second spring (306) reaches the maximum and the second sleeve (305) can no longer move, the sampling hole (303) is located directly above the test tube. Step 2: The pump plug (310) continues to move, the piston rod (313) cannot move, the spring (314) is compressed, and the piston (311) continues to move with the pump plug (310), pushing out the liquid medicine in the sampling mechanism (300), and the liquid medicine falls into the test tube through the sampling hole (303). When the piston (311) contacts the sleeve (305), the sampling is completed, and the damping block (317) is inserted into the damping groove (315); Step 3: The pump plug (310) moves in the reverse direction. During this movement, the pump plug (310) moves together with the pump plug rod (312), the piston (311) and the piston rod (313). The second spring (306) releases its elastic force, causing the second sleeve (305), the connecting pipe (308) and the first sleeve (302) to return to their original positions. When the pressure plate contacts the pump housing (309), the pump plug (310) continues to move in the reverse direction. The unlocking rod (319) remains stationary and squeezes the connecting rod, causing the damping block (317) to disengage from the damping groove (315). The third spring (314) releases its elastic force, causing the piston rod (313) to return to its original position.

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