A food-medicine composition and its use in the preparation of a treatment for lung injury

Abstract

This invention belongs to the field of traditional Chinese medicine technology, specifically relating to a food-medicine homology composition and its use in the preparation of a treatment for lung injury. The food-medicine homology composition of this invention comprehensively considers the overall state of the body and the intrinsic physiological functions of the lungs. Its main active ingredients are lung-protecting food-medicine homology materials and small-molecule collagen peptides. Specifically, *Siraitia grosvenorii* (monk fruit) and *Lilium brownii* (lily bulb) are the principal ingredients, while *Eriobotrya japonica* (loquat leaf), *Platycodon grandiflorus* (platycodon root), *Lonicera japonica* (honeysuckle flower), and *Morus alba* (mulberry leaf) are the assistant ingredients. The adjuvant ingredients include *Dioscorea opposita* (Chinese yam), *Codonopsis pilosula* (codonopsis root), *Astragalus membranaceus* (astragalus root), *Pyrus pyrifolia* (snow pear), *Tremella fuciformis* (white fungus), and olive. These ingredients have the effects of clearing heat and moistening the lungs, invigorating qi and strengthening the spleen, and nourishing yin and moistening dryness. Combined with small-molecule collagen peptides, it comprehensively regulates lung tissue, helps improve lung function, promotes lung repair, and achieves lung-protecting effects, making it suitable for the treatment of lung injury.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine technology. Specifically, it relates to a food-medicine homology composition and its use in the preparation of a treatment for lung injury. Background Technology

[0002] The lungs, located at the highest position among the five viscera and connected to the skin and hair, are a delicate organ, intolerant of both cold and heat. As a organ responsible for cleansing and purifying, they are also susceptible to damage from external and internal factors, leading to disease. The lungs govern qi and respiration; therefore, lung diseases are primarily characterized by abnormal qi circulation, with common symptoms including lung qi deficiency, yin deficiency, invasion of the lungs by cold pathogens, invasion of the lungs by pathogenic heat, and obstruction of the lungs by phlegm. The basic pathogenesis of lung injury is due to external pathogens or phlegm obstructing the flow of qi, impairing the lung's function of dispersing and purifying qi, or due to overwork or prolonged illness leading to deficiency of lung qi and yin, resulting in the lungs' inability to govern qi. Because the lungs fail to disperse and descend qi, cough and wheezing are common symptoms. Because the lungs do not govern qi, shortness of breath, spontaneous sweating, and susceptibility to colds are common symptoms. The lungs govern all the blood vessels and assist the heart in regulating qi. If the lung qi is imbalanced and fails to govern all the blood vessels, it can lead to poor blood circulation in the heart, resulting in palpitations, chest tightness, and purplish lips and nails. The lungs regulate water metabolism. If the lungs fail to disperse and descend qi and fail to regulate water metabolism, it can lead to edema and difficulty urinating.

[0003] For lung heat toxicity syndrome, treatment focuses on clearing heat, detoxifying, and resolving phlegm. Commonly used herbs include honeysuckle, forsythia, scutellaria, coptis, phellodendron, and houttuynia cordata. Formulas such as Qingwen Baidu Decoction and Qingjin Huatan Decoction are used to clear heat, resolve phlegm, regulate qi, and stop coughing. For lung phlegm and blood stasis syndrome, treatment focuses on removing phlegm, resolving blood stasis, unblocking meridians, and stopping coughing. Formulas such as Ditan Decoction and Xuefu Zhuyu Decoction can be used with modifications. Blood-activating and stasis-resolving herbs such as peach kernel, safflower, and salvia miltiorrhiza can improve pulmonary microcirculation, promote qi and blood circulation, and reduce pulmonary congestion. For lung qi and yin deficiency syndrome, the main symptoms are dry cough with little phlegm, dry throat, and dry nose. A representative formula is Sha Shen Mai Dong Decoction, which clears and nourishes the lungs and stomach, and replenishes both qi and yin; Shengmai Powder can replenish qi and yin, astringe yin and stop sweating, improve the body's immunity, and promote the recovery of lung function. For lung qi deficiency syndrome, the main symptoms are weak cough, shortness of breath, and spontaneous sweating. For lung deficiency, it is advisable to tonify the lungs and replenish qi, using herbs such as ginseng and astragalus to strengthen the lungs and enhance lung function, thereby improving the body's resistance. For lung yin deficiency, commonly manifested as dry cough with little sputum and hemoptysis, it is advisable to nourish yin and moisten the lungs, using the Sha Shen Mai Dong Tang formula as a common prescription to nourish lung yin, clear heat, and moisten the lungs. For chronic cough due to lung deficiency, the main symptoms are persistent cough, shortness of breath, and fatigue. It is advisable to astringe the lungs and stop coughing, using herbs such as schisandra and dried plum to astringe lung qi, stop coughing, and relieve asthma.

[0004] For daily lung care, lung health can be maintained through dietary adjustments, regular daily routines, appropriate exercise, and mood regulation. In addition, Traditional Chinese Medicine (TCM) is characterized by significant efficacy and high safety. It can maintain lung physiological function and thus play a protective role through the combined effects of multiple components, multiple targets, multiple effects, and integrated coordination. Summary of the Invention

[0005] The present invention aims to develop new and effective lung-protecting compositions to protect lung and respiratory health, for the treatment of lung injury, and using food-grade medicinal materials, which are highly safe, inexpensive and have no toxic side effects.

[0006] The purpose of this invention is to provide a food-medicine homology composition.

[0007] Another objective of this invention is to provide a method for preparing a food-medicine homology composition.

[0008] Another object of the present invention is to provide the application of the aforementioned food-medicine homology composition in the preparation of products for treating lung injury.

[0009] The above-mentioned objective of this invention is achieved through the following technical solution:

[0010] In a first aspect, the present invention provides a food-medicine composition comprising the following components: lung-protecting food-medicine materials and small molecule collagen peptides;

[0011] The ratio of the lung-protecting food-derived material to small molecule collagen peptides is 100:4~9;

[0012] The unit of the lung-protecting food-medicine homology material is parts by weight; the unit of small molecule collagen peptide is grams (g).

[0013] The lung-protecting medicinal and edible ingredients include snow pear, lily bulb, Chinese yam, monk fruit, loquat leaf, honeysuckle, white fungus, mulberry leaf, platycodon root, codonopsis root, astragalus root, and olive.

[0014] Preferably, the ratio of the lung-protecting food-medicine homology material to the small molecule collagen peptide is 100:4~9;

[0015] The unit of the lung-protecting food-medicine homology material is parts by weight; the unit of small molecule collagen peptide is grams (g).

[0016] The lung-protecting medicinal and edible materials include the following components in parts by weight: 5-9 parts snow pear, 12-35 parts lily bulb, 4-10 parts Chinese yam, 12-35 parts monk fruit, 5-8 parts loquat leaf, 8-12 parts honeysuckle, 6-10 parts white fungus, 5-8 parts mulberry leaf, 5-10 parts platycodon root, 8-12 parts codonopsis root, 8-12 parts astragalus root, and 3-6 parts olive.

[0017] Most preferably, the ratio of the lung-protecting food-derived material to the small molecule collagen peptide is 100:5~8;

[0018] The unit of the lung-protecting food-medicine homology material is parts by weight; the unit of small molecule collagen peptide is grams (g).

[0019] The lung-protecting medicinal and edible materials include the following components in parts by weight: 6-8 parts snow pear, 20-30 parts lily bulb, 5-8 parts Chinese yam, 20-30 parts monk fruit, 6-7 parts loquat leaf, 9-10 parts honeysuckle, 7-9 parts white fungus, 6-7 parts mulberry leaf, 6-8 parts platycodon root, 8-10 parts codonopsis root, 8-10 parts astragalus root, and 4-5 parts olive.

[0020] Secondly, the present invention provides a method for preparing the aforementioned food-medicine homology composition, comprising the following steps:

[0021] (1) Weigh the lung-protecting food-medicine homologous material and small molecule collagen peptides accurately according to the dosage ratio of 100:4~9, and set aside;

[0022] (2) Soak the lung-protecting food and medicine materials in 5 to 10 times the volume of pure water for 30 minutes, boil over high heat until boiling, then simmer over low heat for 20 to 40 minutes, remove the residue and keep the filtrate;

[0023] (3) After the obtained filtrate is concentrated 4 to 7 times, it is mixed with the small molecule collagen peptide to obtain the final product;

[0024] The unit of the lung-protecting food-medicine homology material is parts by weight; the unit of small molecule collagen peptide is grams (g).

[0025] Preferably, the preparation method of the food-medicine homology composition includes the following steps:

[0026] (1) Weigh the lung-protecting food-medicine homologous material and small molecule collagen peptides accurately according to the dosage ratio of 100:5~8, and set aside;

[0027] (2) Soak the lung-protecting food and medicine materials in 5 to 10 times the volume of pure water for 30 minutes, boil over high heat until boiling, then simmer over low heat for 20 to 40 minutes, remove the residue and keep the filtrate;

[0028] (3) After the obtained filtrate is concentrated 4 to 7 times, it is mixed with the small molecule collagen peptide to obtain the final product;

[0029] The unit of the lung-protecting food-medicine homology material is parts by weight; the unit of small molecule collagen peptide is grams (g).

[0030] Most preferably, the preparation method of the food-medicine homology composition includes the following steps:

[0031] (1) Weigh the lung-protecting food-medicine homologous material and small molecule collagen peptides accurately according to the dosage ratio of 100:5~8, and set aside;

[0032] (2) Soak the lung-protecting food and medicine materials in 5 to 10 times the volume of pure water for 30 minutes, boil over high heat until boiling, then simmer over low heat for 20 to 40 minutes, remove the residue and keep the filtrate;

[0033] (3) After the obtained filtrate is concentrated 5 times, it is mixed with the small molecule collagen peptide to obtain the final product;

[0034] The unit of the lung-protecting food-medicine homology material is parts by weight; the unit of small molecule collagen peptide is grams (g).

[0035] Thirdly, the present invention provides the application of the above-mentioned food-medicine homology composition in the preparation of products for treating lung injury.

[0036] Preferably, the product for treating lung injury is a pharmaceutical product.

[0037] Analysis of the formulation of the food-medicine homology composition of the present invention: Luo Han Guo (monk fruit) and lily bulb are the principal ingredients, playing a key role in clearing heat, moistening the lungs, nourishing yin, and relieving cough. The assistant ingredients are loquat leaf, platycodon root, honeysuckle, and mulberry leaf, which assist the principal ingredients in enhancing their effects of clearing heat, detoxifying, resolving phlegm, and relieving cough, thus alleviating lung inflammation and phlegm problems. Chinese yam, codonopsis root, astragalus root, and snow pear mainly play a role in invigorating qi and strengthening the spleen, providing nutritional support to the body, enhancing the body's resistance, and assisting in the recovery of lung function. Tremella and olive enhance the effect of nourishing yin and moistening dryness, assisting the principal and assistant ingredients in relieving lung dryness symptoms. The heat-clearing and lung-moistening materials and the phlegm-resolving and cough-relieving materials work together to effectively relieve lung discomfort symptoms; the qi-invigorating and spleen-strengthening materials enhance the body's vital energy, improve the body's resistance and repair ability, and are beneficial to the recovery of lung function; the yin-nourishing and dryness-moistening materials can help improve insufficient yin fluid in the lungs and maintain normal lung physiological function.

[0038] Modern medical research shows that small molecule collagen peptides can improve airway elasticity, enhance the generation and distribution of lung qi, and alleviate symptoms such as difficulty breathing by ensuring sufficient lung qi. They can also serve as an important substance for repairing damaged tissues, nourishing lung tissues, and promoting the repair and regeneration of lung tissues. Furthermore, they have antioxidant functions, which help delay the aging process of lung tissues and maintain normal lung physiological functions.

[0039] The food-medicine composition of the present invention takes into account the overall condition of the body and the inherent physiological function of the lungs. Through the effects of invigorating qi and strengthening the spleen, nourishing yin and moistening dryness, and combined with small molecule collagen peptides, it comprehensively regulates lung tissue, helps improve lung function, promotes lung repair, and achieves lung protection effects. It can be used to treat lung injury.

[0040] The medicinal and edible homologous compositions of the present invention use the following medicinal and edible homologous materials:

[0041] Snow pear: It is sweet and cool in nature, and can clear heat and moisten the lungs, promote body fluid and quench thirst. It can relieve symptoms such as dry cough with little phlegm and dry throat caused by lung dryness.

[0042] Lily bulb: It has a sweet taste and cold nature. It enters the heart and lung meridians and has the effects of moistening the lungs and relieving cough, clearing the heart and calming the mind. It is good at nourishing lung yin and has a good effect on cough and hemoptysis due to yin deficiency and lung dryness.

[0043] Chinese yam: It is sweet in taste and neutral in nature. It enters the spleen, lung and kidney meridians. It can nourish the spleen and stomach, promote body fluid and benefit the lungs, and nourish the kidneys and astringe essence. It has a tonic effect on symptoms such as spleen deficiency and poor appetite, and lung qi deficiency. It can provide nutritional support to the human body and enhance the body's resistance.

[0044] Monk fruit: It has a sweet taste and cool nature. It enters the lung and large intestine meridians. It has the functions of clearing heat and detoxifying, resolving phlegm and relieving cough, nourishing the voice and moistening the lungs. It has a certain relieving effect on lung heat cough, dry cough and other conditions.

[0045] Loquat leaves: bitter in taste, slightly cold in nature, enter the lung and stomach meridians, have the effects of clearing the lungs and relieving cough, and suppressing nausea and vomiting. They are often used to treat symptoms such as lung heat cough and shortness of breath.

[0046] Honeysuckle: It is cold in nature and sweet in taste. It enters the lung, heart and stomach meridians. It is good at clearing heat and detoxifying, and dispersing wind-heat. It is often used to treat the initial stage of febrile diseases, carbuncles and other diseases caused by heat toxins. It is also helpful for sore throat, cough and phlegm caused by lung heat.

[0047] White fungus: It has a sweet and bland taste, and is neutral in nature. It enters the lung, stomach, and kidney meridians. It has the effects of nourishing yin and moistening the lungs, nourishing the stomach and promoting body fluids, and moisturizing the skin and beautifying the complexion. It can relieve symptoms such as dry cough and thirst caused by lung dryness.

[0048] Mulberry leaves: They are cold in nature, sweet and bitter in taste, and enter the lung and liver meridians. They have the effects of dispersing wind-heat, clearing the lungs and moistening dryness, and clearing the liver and improving eyesight. They are suitable for lung heat cough, dry cough, etc.

[0049] Platycodon grandiflorus: It tastes bitter and pungent, is neutral in nature, and enters the lung meridian. It has the effects of clearing the lungs, relieving sore throat, eliminating phlegm, and draining pus. It has a good therapeutic effect on cough with excessive phlegm and sore throat, and can promote the expulsion of phlegm and relieve respiratory discomfort.

[0050] Codonopsis pilosula: It is neutral in nature and sweet in taste. It enters the spleen and lung meridians and has the effects of tonifying the middle energizer and replenishing qi, strengthening the spleen and benefiting the lungs. It is suitable for symptoms such as spleen and lung qi deficiency, fatigue, loss of appetite and loose stools. It can enhance the body's immune function.

[0051] Astragalus: It is slightly warm in nature and sweet in taste. It enters the lung and spleen meridians. It has the effects of tonifying qi and raising yang, consolidating the exterior and stopping sweating, promoting diuresis and reducing swelling, generating fluids and nourishing blood, promoting circulation and relieving pain, promoting detoxification and draining pus, and promoting wound healing and tissue regeneration. It can enhance the body's immunity and improve the functional state of organs such as the lungs and spleen. It has a good effect on improving symptoms such as cough, shortness of breath and fatigue caused by lung qi deficiency.

[0052] Olives are neutral in nature, sweet and sour in taste, and enter the lung and stomach meridians. They have the effects of clearing the lungs and relieving sore throat, promoting body fluid production and quenching thirst, and detoxifying and sobering up. They also have a certain auxiliary therapeutic effect on sore throat, cough and other ailments.

[0053] The present invention has the following beneficial effects:

[0054] The medicinal and edible composition of this invention takes into account the overall state of the body and the inherent physiological functions of the lungs. It uses monk fruit and lily as the principal ingredients, loquat leaf, platycodon root, honeysuckle, and mulberry leaf as the assistant ingredients, and Chinese yam, codonopsis root, astragalus root, snow pear, white fungus, and olive as adjuvant ingredients. It has the effects of clearing heat and moistening the lungs, invigorating qi and strengthening the spleen, and nourishing yin and moistening dryness. Combined with small molecule collagen peptides, it comprehensively regulates lung tissue, helps improve lung function, promotes lung repair, and achieves lung protection effects. It can be used to treat lung injury.

[0055] Validated in chronic lung injury studies, the food-medicine homology composition of this invention significantly reduces the inflammatory marker IL-1β, the pulmonary fibrosis marker α-SMA, and the relative expression level of Cyclin D1, a key marker of lung injury and pulmonary fibrosis. Validated in inflammatory lung injury studies, the food-medicine homology composition of this invention significantly improves the cell viability of bronchial epithelial cells. Attached Figure Description

[0056] Figure 1 The values ​​represent the relative expression levels of IL-1β, α-SMA, and Cyclin D1 in mouse lung tissue. Detailed Implementation

[0057] The present invention will be further described below with reference to the accompanying drawings and specific embodiments, but the embodiments do not limit the present invention in any way.

[0058] Unless otherwise specified, the reagents, methods and equipment used in this invention are conventional reagents, methods and equipment in this technical field.

[0059] Unless otherwise specified, all reagents and materials used in the following examples are commercially available.

[0060] Example 1

[0061] A food-medicine composition comprising the following components: lung-protecting food-medicine materials and small molecule collagen peptides;

[0062] The ratio of the lung-protecting food-derived material to small molecule collagen peptides is 100:6.

[0063] The unit of the lung-protecting food-medicine homology material is parts by weight; the unit of small molecule collagen peptide is grams (g).

[0064] The lung-protecting medicinal and edible materials include the following components in parts by weight: 7 parts snow pear, 25 parts lily bulb, 7 parts Chinese yam, 25 parts monk fruit, 6 parts loquat leaf, 9 parts honeysuckle, 8 parts white fungus, 7 parts mulberry leaf, 8 parts platycodon root, 10 parts codonopsis root, 10 parts astragalus root, and 5 parts olive.

[0065] The amino acid sequence of the small molecule collagen peptide is shown in SEQ ID NO.1.

[0066] The preparation method of the medicinal and edible homology composition includes the following steps:

[0067] (1) Weigh the lung-protecting food-medicine homologous material and the small molecule collagen peptide accurately according to the dosage ratio of 100:6, and set aside;

[0068] (2) Soak the lung-protecting medicinal and edible materials in 8 times the volume of purified water for 30 minutes, boil them over high heat until boiling, then simmer over low heat for 25 minutes, remove the residue and keep the filtrate.

[0069] (3) After the obtained filtrate is concentrated by 5 times, it is mixed with the small molecule collagen peptide to obtain the final product.

[0070] Example 2

[0071] A food-medicine composition comprising the following components: lung-protecting food-medicine materials and small molecule collagen peptides;

[0072] The ratio of the lung-protecting food-derived material to small molecule collagen peptides is 100:8.

[0073] The unit of the lung-protecting food-medicine homology material is parts by weight; the unit of small molecule collagen peptide is grams (g).

[0074] The lung-protecting medicinal and edible materials include the following components by weight: 8 parts snow pear, 30 parts lily bulb, 8 parts Chinese yam, 30 parts monk fruit, 7 parts loquat leaf, 10 parts honeysuckle, 9 parts white fungus, 7 parts mulberry leaf, 8 parts platycodon root, 10 parts codonopsis root, 10 parts astragalus root, and 5 parts olive.

[0075] The amino acid sequence of the small molecule collagen peptide is shown in SEQ ID NO.1.

[0076] The preparation method of the medicinal and edible homology composition includes the following steps:

[0077] (1) Weigh the lung-protecting food-medicine homologous material and the small molecule collagen peptide accurately at a ratio of 100:8, and set aside;

[0078] (2) Soak the lung-protecting food-medicine material in 10 times its volume of purified water for 30 minutes, boil it over high heat until boiling, then simmer over low heat for 35 minutes, remove the residue and keep the filtrate.

[0079] (3) After the obtained filtrate is concentrated by 5 times, it is mixed with the small molecule collagen peptide to obtain the final product.

[0080] Example 3

[0081] A food-medicine composition comprising the following components: lung-protecting food-medicine materials and small molecule collagen peptides;

[0082] The ratio of the lung-protecting food-derived material to the small molecule collagen peptide is 100:5.

[0083] The unit of the lung-protecting food-medicine homology material is parts by weight; the unit of small molecule collagen peptide is grams (g).

[0084] The lung-protecting medicinal and edible materials include the following components in parts by weight: 6 parts snow pear, 20 parts lily bulb, 5 parts Chinese yam, 20 parts monk fruit, 6 parts loquat leaf, 9 parts honeysuckle, 7 parts white fungus, 6 parts mulberry leaf, 6 parts platycodon root, 8 parts codonopsis root, 8 parts astragalus root, and 4 parts olive.

[0085] The amino acid sequence of the small molecule collagen peptide is shown in SEQ ID NO.1.

[0086] The preparation method of the medicinal and edible homology composition includes the following steps:

[0087] (1) Weigh the lung-protecting food-medicine homologous material and the small molecule collagen peptide accurately according to the dosage ratio of 100:5, and set aside;

[0088] (2) Soak the lung-protecting food and medicine materials in 6 times the volume of purified water for 30 minutes, boil over high heat until boiling, then simmer over low heat for 20 minutes, remove the residue and keep the filtrate.

[0089] (3) After the obtained filtrate is concentrated 5 times, it is mixed with the small molecule collagen peptide to obtain the final product;

[0090] The unit of the lung-protecting food-medicine homology material is parts by weight; the unit of small molecule collagen peptide is grams (g).

[0091] Comparative Example 1

[0092] A food-medicine composition comprising the following components: lung-protecting food-medicine materials and small molecule collagen peptides;

[0093] The ratio of the lung-protecting food-derived material to small molecule collagen peptides is 100:8.

[0094] The unit of the lung-protecting food-medicine homology material is parts by weight; the unit of small molecule collagen peptide is grams (g).

[0095] The lung-protecting medicinal and edible materials include the following components by weight: 8 parts snow pear, 30 parts lily bulb, 8 parts Chinese yam, 30 parts monk fruit, 7 parts loquat leaf, 10 parts honeysuckle, 9 parts white fungus, 7 parts mulberry leaf, 8 parts platycodon root, 10 parts codonopsis root, 10 parts astragalus root, and 5 parts olive.

[0096] The amino acid sequence of the small molecule collagen peptide is shown in SEQ ID NO.2.

[0097] The preparation method of the medicinal and edible homologous composition is the same as in Example 2.

[0098] Comparative Example 2

[0099] A food-medicine composition comprising the following components: lung-protecting food-medicine materials and small molecule collagen peptides;

[0100] The ratio of the lung-protecting food-derived material to small molecule collagen peptides is 100:6.

[0101] The unit of the lung-protecting food-medicine homology material is parts by weight; the unit of small molecule collagen peptide is grams (g).

[0102] The lung-protecting medicinal and edible materials include the following components by weight: 7 parts snow pear, 7 parts Chinese yam, 50 parts monk fruit, 11 parts honeysuckle, 8 parts white fungus, 9 parts mulberry leaf, 10 parts platycodon, 10 parts codonopsis, 10 parts astragalus, and 5 parts olive.

[0103] The amino acid sequence of the small molecule collagen peptide is shown in SEQ ID NO.1.

[0104] The preparation method of the medicinal and edible homology composition is the same as in Example 1.

[0105] Experimental Example 1: Validation of the effect on chronic lung injury

[0106] Following the method of Wang Ye et al. (Wang Ye et al. Chronic lung injury induced by gasoline engine exhaust in rats and its effect on the expression of different types of collagen [J]. Journal of Environment and Health, 2012), a chronic lung injury animal model induced by gasoline engine exhaust was prepared using male Kunming mice.

[0107] SPF-grade male adult Kunming mice, weighing 30-40g, were randomly divided into 6 groups: a control group and a negative control group (n=3 per group), and a treatment group (n=5 per group). The control group received no treatment. The mice in the negative control group and the treatment group were placed in a toxic fumes chamber. Exhaust fumes from a gasoline engine were introduced into the chamber through an opening on the side of the chamber. The mice received this fumes for 2 hours daily for 8 weeks. After daily fumes treatment, the treatment groups were administered the food-medicine homologous compositions of Examples 1-2 and Comparative Examples 1-2 via gavage at a dose of 0.2ml / 10g. The mice were sacrificed within 24 hours after the last fumes treatment, and tissue samples were collected to detect the expression of IL-1β, α-SMA, and Cyclin D1 proteins in the lung tissue, using GAPDH as an internal control. Results are shown below. Figure 1*** Compared with the negative group, p<0.001; # Compared with the corresponding treatment group, p<0.05; ## Compared with the corresponding treatment group, p<0.01; ### Compared with the corresponding treatment group, p<0.01.

[0108] In an animal model of chronic lung injury caused by gasoline engine exhaust, the expression levels of IL-1β, α-SMA, and Cyclin D1 were significantly elevated in lung tissue. IL-1β is a common inflammatory marker of lung injury, α-SMA is a marker of pulmonary fibrosis, and Cyclin D1 can simultaneously characterize the occurrence of lung injury and pulmonary fibrosis. The food-medicine homology composition of this invention can significantly improve the elevated expression levels of IL-1β, α-SMA, and Cyclin D1 in model mice. The results of Example 2 and Comparative Example 1 confirm that the selection of small molecule collagen peptides is closely related to the conditioning effect on lung tissue. The small molecule collagen peptides in the food-medicine homology composition of this invention help improve lung function, promote lung repair, achieve lung protection effects, and can treat lung injury. The results of Example 1 and Comparative Example 2 confirm that the formulation structure, with Luo Han Guo and Lily as the principal herbs and Loquat Leaf, Platycodon, Honeysuckle, and Mulberry Leaf as the assistant herbs, affects the overall therapeutic effect of the composition on lung injury and is the key to its efficacy.

[0109] Experimental Example 2: Validation of the effect on inflammatory lung injury

[0110] Human normal bronchial epithelial cells BEAS-2B were selected and cultured stably in 96-well plates until 80% confluence. Then, 5 μg / mL LPS was added for 18 h to establish an inflammatory lung injury cell model. The blank group received an equal volume of PBS buffer. The treatment groups, while establishing the inflammatory lung injury cell model, received 30 μg / mL of the food-medicine homologous compositions from Examples 1-3 and Comparative Examples 1-2. Each group had 5 replicates, and cell viability was measured using the CCK-8 assay. Results are shown in Table 1. * Significant difference compared to the model group (p<0.05); # Significant difference compared to the corresponding example group (p<0.05).

[0111] Table 1 Cell Viability

[0112] Group Sample size Cell viability (%) blank 6 100 Model 6 61.85±8.64 Example 1 6 84.40±5.91* Example 2 6 86.12±7.66* Example 3 6 83.91±8.04* Comparative Example 1 6 72.63±7.18# Comparative Example 2 6 74.19±6.72#

[0113] In a cell model of LPS-induced inflammatory lung injury, the food-derived composition of the present invention can significantly enhance the vitality of bronchial epithelial cells, thereby helping to improve lung function and promote lung repair.

[0114] The basic principles, main features, and advantages of this invention have been described above. Those skilled in the art should understand that this invention is not limited to the above embodiments. The embodiments and descriptions in the specification are merely principles of the invention. Various changes and modifications can be made without departing from the spirit and scope of the invention, and all such changes and modifications fall within the scope of the invention as claimed. The scope of protection claimed by this invention is defined by the appended claims and their equivalents.

Claims

1. A medicinal and edible composition, characterized in that, It includes the following components: lung-protecting medicinal and edible materials, and small molecule collagen peptides; The ratio of the lung-protecting food-derived material to small molecule collagen peptides is 100:4~9; The unit of the lung-protecting food-medicine homology material is parts by weight; the unit of small molecule collagen peptide is grams (g). The amino acid sequence of the small molecule collagen peptide is shown in SEQ ID NO.1; The lung-protecting medicinal and edible materials include the following components in parts by weight: 5-9 parts snow pear, 12-35 parts lily bulb, 4-10 parts Chinese yam, 12-35 parts monk fruit, 5-8 parts loquat leaf, 8-12 parts honeysuckle, 6-10 parts white fungus, 5-8 parts mulberry leaf, 5-10 parts platycodon root, 8-12 parts codonopsis root, 8-12 parts astragalus root, and 3-6 parts olive.

2. The medicinal and edible composition according to claim 1, characterized in that, The lung-protecting medicinal and edible materials include the following components in parts by weight: 6-8 parts snow pear, 20-30 parts lily bulb, 5-8 parts Chinese yam, 20-30 parts monk fruit, 6-7 parts loquat leaf, 9-10 parts honeysuckle, 7-9 parts white fungus, 6-7 parts mulberry leaf, 6-8 parts platycodon root, 8-10 parts codonopsis root, 8-10 parts astragalus root, and 4-5 parts olive.

3. The medicinal and edible composition according to claim 1, characterized in that, The ratio of the lung-protecting food-derived material to the small molecule collagen peptide is 100:5~8.

4. The method for preparing the food-medicine homology composition according to claim 1, comprising the following steps: (1) Weigh the lung-protecting food-medicine homologous material and small molecule collagen peptides accurately according to the dosage ratio of 100:4~9, and set aside; (2) Soak the lung-protecting food and medicine materials in 5 to 10 times the volume of pure water for 30 minutes, boil over high heat until boiling, then simmer over low heat for 20 to 40 minutes, remove the residue and keep the filtrate; (3) After the obtained filtrate is concentrated by 4 to 7 times, it is mixed with the small molecule collagen peptide to obtain the final product.

5. The preparation method according to claim 4, characterized in that, Includes the following steps: (1) Weigh the lung-protecting food-medicine homologous material and small molecule collagen peptides accurately according to the dosage ratio of 100:5~8, and set aside; (2) Soak the lung-protecting food and medicine materials in 5 to 10 times the volume of pure water for 30 minutes, boil over high heat until boiling, then simmer over low heat for 20 to 40 minutes, remove the residue and keep the filtrate; (3) After the obtained filtrate is concentrated by 4 to 7 times, it is mixed with the small molecule collagen peptide to obtain the final product.

6. The preparation method according to claim 4, characterized in that, In step (3), the obtained filtrate is concentrated 5 times and then mixed with the small molecule collagen peptide.

7. The use of the food-medicine homology composition according to claim 1 in the preparation of products for treating lung injury; The product described for treating lung injury is a pharmaceutical product.

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