Plastic hot compress film compounded with traditional Chinese medicine essential oil, preparation method and hot compress method

Abstract

The invention provides a plastic hot compress film compounded with traditional Chinese medicine essential oil, a preparation method and a hot compress method. The plastic hot compress film comprises a plastic film body and a functional composition dispersed in the plastic film body, the functional composition comprises the following components in parts by mass: 6-15 parts of a traditional Chinese medicine essential oil composition, 0.5-3 parts of far infrared powder and 0.5-3 parts of a penetration enhancer; wherein the traditional Chinese medicine essential oil composition at least comprises five of musk essential oil, ginger essential oil, cinnamon essential oil, clove essential oil, garden balsam stem essential oil, ligusticum wallichii essential oil and safflower essential oil. A traditional Chinese medicine essential oil composition for wind-cold-dampness arthralgia is dispersed and manufactured in a plastic film body, and the plastic film body is used as a functional composition carrier, so that a windable mechanical basis is provided; the prepared hot covering film can be wound on the joint in multiple layers, and the falling rate of the film is greatly reduced when the joint moves and is far smaller than that of a plaster patch. The traditional Chinese medicine essential oil composition is helpful for treating wind-cold-dampness arthralgia, and the far infrared powder can achieve a hot compress effect by means of the body temperature of a human body during use.

Description

Technical Field

[0001] This invention relates to the field of medical polymer composite materials, specifically to a plastic heat-coating film made of composite Chinese herbal essential oils, its preparation method, and its heat-coating method. Background Technology

[0002] Currently, many diseases such as wind-cold-dampness arthralgia are treated with medicated plasters. For example, Chinese invention patent CN107050118B provides a traditional Chinese medicine plaster for treating wind-cold-dampness arthralgia and its preparation method. It uses ingredients such as clove, cinnamon, borneol, angelica, and plaster base. The plaster base is heated and melted, and then mixed with medicinal powder and stirred evenly. After 30 minutes, a certain amount of plaster is applied to a breathable dressing or plaster cloth, and then oil paper is applied to the plaster to make it.

[0003] When this plaster is applied to a joint, it is easy to fall off during joint movement, causing inconvenience. If a strong adhesive layer is applied to the plaster, it may cause skin allergies and damage to the user.

[0004] In view of the above, this application is hereby submitted. Summary of the Invention

[0005] This invention provides a plastic heat-compressing film with compound Chinese herbal essential oils to solve at least one of the above-mentioned technical problems.

[0006] To address the above problems, as one aspect of the present invention, a plastic heat compress film containing composite Chinese herbal essential oils includes a plastic film body and a functional composition dispersed in the plastic film body.

[0007] The functional composition comprises the following components in parts by weight: 15-25 parts of traditional Chinese medicine essential oil composition, 1-2 parts of far-infrared powder, and 1.5-3 parts of penetration enhancer;

[0008] The herbal essential oil composition contains at least five of the following: musk essential oil, ginger essential oil, cinnamon essential oil, clove essential oil, Clematis chinensis essential oil, Ligusticum chuanxiong essential oil, and safflower essential oil.

[0009] Preferably, the herbal essential oil composition comprises 1-1.5 parts of musk essential oil, 1-1.5 parts of ginger essential oil, 1-1.5 parts of cinnamon essential oil, 1-1.5 parts of clove essential oil, 1-1.5 parts of Clematis chinensis essential oil, 1-1.5 parts of Ligusticum chuanxiong essential oil, 1-1.5 parts of safflower essential oil, 1-1.5 parts of Salvia miltiorrhiza essential oil, 1-1.5 parts of Notopterygium incisum essential oil, 1-1.5 parts of Angelica pubescens essential oil, 1-1.5 parts of Artemisia argyi essential oil, 1-1.5 parts of Panax notoginseng essential oil, 1-1.5 parts of Achyranthes bidentata essential oil, 1-1.5 parts of Corydalis yanhusuo essential oil, 1-1.5 parts of Angelica sinensis essential oil, 1-1.5 parts of myrrh essential oil, 1-1.5 parts of frankincense essential oil, and 1-1.5 parts of grape seed essential oil.

[0010] Preferably, the functional composition further comprises 1.5 parts of medical glycerin.

[0011] Preferably, the plastic film body is PE, PP and / or TPU.

[0012] Preferably, the plastic film body comprises 70-90 parts by weight, and the functional composition comprises 10-30 parts by weight.

[0013] Preferably, the penetration enhancer is a mixture of azone and vanillyl butyl ether at a ratio of 1:0.2 to 1:1.

[0014] This application also provides a method for preparing a plastic heat-compressing film, comprising:

[0015] S1, 10-30 parts by weight of the functional composition described above are melt-blended and granulated with 20-40 parts by weight of plastic particles to obtain masterbatch;

[0016] S2, melt-blend and granulate 40-50 parts by mass of masterbatch and 50-70 parts by mass of plastic particles to obtain film particles;

[0017] S3, membrane particles are processed into thin films using a blown film machine or casting equipment;

[0018] S4, slitting and packaging.

[0019] Preferably, the processing temperature for melt blending and granulation is 160-200℃.

[0020] This application also provides a method for applying heat with a plastic heat-applying film, wherein the plastic heat-applying film as described above is wrapped in multiple layers around a human joint or abdomen, and the functional composition is activated by body temperature heating.

[0021] This invention disperses a traditional Chinese medicine essential oil composition for wind-cold-dampness arthralgia within a plastic film body, using the plastic film body as a carrier for the functional composition, providing a mechanical basis for winding; the resulting heat-coated film can be wrapped in multiple layers around the joint, greatly reducing the film shedding rate during joint movement, which is far less than that of medicated plasters.

[0022] The herbal essential oil composition (15-25 parts) activates the TRPV1 thermal receptor through volatile terpenes (such as gingerol and muscone) and inhibits the COX-2 inflammatory pathway. The far-infrared powder (1-2 parts) converts human body heat energy into 8-14μm wavelength radiation via germanium / ceramic compounds, resonating with water molecules. The penetration enhancer (1.5-3 parts) disrupts the lipid bilayer of the stratum corneum through azone and opens instantaneous water channels with vanillyl butyl ether. This significantly improves the transdermal penetration rate of the essential oil and increases the temperature 3mm below the skin during application, achieving a heat therapy effect, which is particularly beneficial for the treatment and pain relief of wind-cold-dampness syndrome. Attached Figure Description

[0023] Figure 1This is a schematic flowchart of the preparation method of the plastic heat-coating film according to an embodiment of the present invention. Detailed Implementation

[0024] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only a part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention. Therefore, the following detailed description of the embodiments of the present invention provided in the accompanying drawings is not intended to limit the scope of the claimed invention, but merely to represent selected embodiments of the invention. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0025] In the description of this invention, it should be understood that the terms "center," "longitudinal," "lateral," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," and "outer," etc., indicating orientation or positional relationships, are based on the orientation or positional relationships shown in the accompanying drawings and are only for the convenience of describing this invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this invention. In the description of this invention, unless otherwise stated, "a plurality of" means two or more.

[0026] The specific embodiments of the present invention will be described in detail below with reference to the accompanying drawings.

[0027] A plastic heat compress film containing compound Chinese herbal essential oils includes a plastic film body and a functional composition dispersed in the plastic film body.

[0028] The functional composition comprises the following components in parts by weight: 15-25 parts of a traditional Chinese medicine essential oil composition, 1-2 parts of far-infrared powder, and 1.5-3 parts of a penetration enhancer; wherein the traditional Chinese medicine essential oil composition comprises at least five of the following: musk essential oil, ginger essential oil, cinnamon essential oil, clove essential oil, Clematis chinensis essential oil, Ligusticum chuanxiong essential oil, and safflower essential oil.

[0029] By dispersing a traditional Chinese medicine essential oil composition for wind-cold-dampness arthralgia within a plastic film, and using the plastic film itself as a carrier for the functional composition, a mechanical basis for winding is provided. The resulting heat-coated film can be wrapped in multiple layers around the joint, and the film shedding rate during joint movement is greatly reduced, far less than that of medicated plasters.

[0030] The herbal essential oil composition (15-25 parts) activates the TRPV1 thermal receptor through volatile terpenes (such as gingerol and muscone) and inhibits the COX-2 inflammatory pathway. The far-infrared powder (1-2 parts) converts human body heat energy into 8-14μm wavelength radiation via germanium / ceramic compounds, resonating with water molecules. The penetration enhancer (1.5-3 parts) disrupts the lipid bilayer of the stratum corneum through azone and opens instantaneous water channels with vanillyl butyl ether. This significantly improves the transdermal penetration rate of the essential oil and increases the temperature 3mm below the skin during application, achieving a heat therapy effect, which is particularly beneficial for the treatment and pain relief of wind-cold-dampness syndrome.

[0031] Furthermore, the herbal essential oil composition includes 1-1.5 parts of musk essential oil, 1-1.5 parts of ginger essential oil, 1-1.5 parts of cinnamon essential oil, 1-1.5 parts of clove essential oil, 1-1.5 parts of Clematis chinensis essential oil, 1-1.5 parts of Ligusticum chuanxiong essential oil, 1-1.5 parts of safflower essential oil, 1-1.5 parts of Salvia miltiorrhiza essential oil, 1-1.5 parts of Notopterygium incisum essential oil, 1-1.5 parts of Angelica pubescens essential oil, 1-1.5 parts of Artemisia argyi essential oil, 1-1.5 parts of Panax notoginseng essential oil, 1-1.5 parts of Achyranthes bidentata essential oil, 1-1.5 parts of Corydalis yanhusuo essential oil, 1-1.5 parts of Angelica sinensis essential oil, 1-1.5 parts of myrrh essential oil, 1-1.5 parts of frankincense essential oil, and 1-1.5 parts of grape seed essential oil.

[0032] Further optimization of the herbal essential oil composition improved its effectiveness against wind-cold-dampness syndrome, clarifying the compatibility of 18 essential oils. Grape seed oil was utilized to prevent oxidation, while ferulic acid and tetramethylpyrazine from angelica and chuanxiong essential oils promoted capillary opening and accelerated microcirculation. Furaniculane and boswellic acid from myrrh and frankincense essential oils synergistically inhibited TNF-α; the combination of myrrh and frankincense essential oils enhanced the anti-inflammatory effect by 1.7 times.

[0033] Preferably, the functional composition further comprises 1-1.5 parts of medical-grade glycerin. Medical-grade glycerin can form a hydrogen bond network to lock in moisture, which can prolong the sustained-release time of the herbal essential oil composition; and by inserting glycerin molecules into the polymer chain, it can lower the glass transition temperature, thereby effectively improving the flexibility of the plastic film itself.

[0034] Preferably, the plastic film body is PE, PP, or TPU. TPU forms hydrogen bonds with the carbonyl groups of essential oils through urethane bonds, preventing volatilization and significantly improving the retention rate of essential oils; the β-crystal structure of the PP substrate enhances the dispersion of far-infrared powder, effectively increasing far-infrared radiation power.

[0035] In other embodiments, more preferably, the plastic film body is a mixture of PP and TPU, with a mass fraction of 1-3 parts PP and 1-3 parts TPU. This allows for simultaneous achievement of essential oil retention and enhanced far-infrared radiation effects.

[0036] In other embodiments, more preferably, the plastic film body is a mixture of PE and TPU, with a mass fraction of 1-3 parts PE and 1-3 parts TPU. This allows for simultaneous achievement of essential oil retention and enhanced far-infrared radiation effects.

[0037] In other embodiments, more preferably, the plastic film body is a mixture of PE, PP, and TPU, with the mass fractions being 1-3 parts PE, 1-3 parts PP, and 1-3 parts TPU. This allows for the simultaneous achievement of high essential oil retention, enhanced far-infrared radiation, and improved plastic film toughness.

[0038] Furthermore, the plastic film body comprises 70-90 parts by weight, and the functional composition comprises 10-30 parts by weight. This ensures the tensile strength of the film, and the content of the functional composition can be determined at the critical percolation threshold to ensure continuous component distribution. When the functional composition is less than 10 parts, the infrared radiation intensity drops sharply. When the functional composition is greater than 30 parts, the tear strength of the film decreases.

[0039] Furthermore, the permeation enhancer is a mixture of azone and vanillyl butyl ether at a ratio of 1:0.2 to 1:1. When azone:vanillyl butyl ether is mixed at a ratio of 1:0.2, it preferentially opens the intercellular lipid pathway; when mixed at a ratio of 1:1, it simultaneously activates the aquaporin AQP3, thereby increasing capillary density.

[0040] A method for preparing a plastic heat-compressing film is also provided, comprising:

[0041] S1, 10-30 parts by weight of the functional composition described above are melt-blended and granulated with 20-40 parts by weight of plastic particles to obtain masterbatch; the functional composition is coated by a low proportion of substrate (20-40 parts) and the dispersion uniformity of far-infrared powder is improved.

[0042] In this embodiment, the plastic particles are a mixture of PP and TPU, with a mass fraction of 1-3 parts PP and 1-3 parts TPU.

[0043] In another preferred embodiment, the plastic particles are a mixture of PE, PP, and TPU, with a mass fraction of 1-3 parts PP and 1-3 parts TPU. This allows for the simultaneous achievement of high essential oil retention, enhanced far-infrared radiation, and improved plastic film toughness.

[0044] In other embodiments, the plastic particles may also be one of PE, PP or TPU.

[0045] S2, melt-blend 40-50 parts by weight of masterbatch and 50-70 parts by weight of plastic particles to obtain film particles; by using a high proportion of substrate (50-70 parts), the functional composition is prevented from being thermally decomposed during the subsequent blown film process, thus reducing the heat loss rate of essential oil.

[0046] S3, membrane particles are processed into thin films using a blown film machine or casting equipment;

[0047] S4, Slitting and Packaging: The large roll of film is divided into smaller rolls, and the smaller rolls are slit and packaged according to specifications to form a plastic heat-compression film that is easy to wrap around joints or abdomen.

[0048] Furthermore, the processing temperature for melt blending and granulation is 160-200℃. This processing temperature is lower than the boiling point of essential oils (such as muscarine 254℃) and higher than the melting point of PE (120℃). Preferably, it is 170℃, which can increase the melt flow rate of TPU and ensure that the haze of the film during processing is <15%, thereby guaranteeing transparency.

[0049] In a basic embodiment:

[0050] The functional composition formulation, by weight, is as follows:

[0051] The penetration enhancer consists of 1 part azone, 0.5 parts vanillyl butyl ether, and 1 part medical glycerin.

[0052] And a composition of traditional Chinese medicine essential oils: 1 part musk essential oil, 1 part ginger essential oil, 1 part cinnamon essential oil, 1 part clove essential oil, 1 part Clematis chinensis essential oil, 1 part Ligusticum chuanxiong essential oil, 1 part safflower essential oil, 1 part Salvia miltiorrhiza essential oil, 1 part Notopterygium incisum essential oil, 1 part Angelica pubescens essential oil, 1 part Artemisia argyi essential oil, 1 part Panax notoginseng essential oil, 1 part Achyranthes bidentata essential oil, 1 part Corydalis yanhusuo essential oil, 1 part Angelica sinensis essential oil, 1 part myrrh essential oil, 1 part frankincense essential oil, and 1 part grape seed essential oil, totaling 18 ingredients, with 1 part of each ingredient as the standard. Far-infrared powder: 1.5 parts germanium oxide / ceramic composite powder, with a particle size of 50-80 nm and a normal total emissivity ≥0.88.

[0053] The plastic film body material is as follows: base material: LDPE (low density polyethylene) resin (melt index MI = 2-4 g / 10 min), additives: antioxidant 1010 (0.1 parts), ultraviolet absorber UV-531 (0.05 parts).

[0054] In a preferred embodiment, the best effect is achieved when the components are formulated in the following proportions: 1.2 parts musk essential oil, 1.3 parts ginger essential oil, 1.1 parts cinnamon essential oil, 1.4 parts clove essential oil, 1.2 parts Clematis chinensis essential oil, and 1 part each of the remaining essential oils. The far-infrared powder particle size is optimized to 60-70 nm, and the penetration enhancer is a 3:1 mixture of azone and menthol.

[0055] This preferred embodiment has the following advantages compared to the basic embodiment:

[0056] 1. The transdermal absorption rate of the herbal essential oil components is increased by 40%-60% compared to the basic embodiment. The principle is as follows: Nano-far-infrared powder (60-70nm): Enhances the penetration depth of far-infrared radiation through the quantum size effect (experimentally measured radiation intensity in the 8-14μm band increased by 22%), promotes the oscillation of the lipid bilayer of the stratum corneum, and expands the drug penetration channels. Menthol compound for enhanced penetration: Azone (penetration enhancer) and menthol (cooling agent and penetration enhancer) form a synergistic effect, doubly enhancing skin permeability by interfering with the lipid arrangement of the stratum corneum (action of azone) and activating the TRPM8 cold receptor (action of menthol).

[0057] 2. The thermal effect is optimized, and the temperature at 3mm below the skin is stably maintained at 40.5-42.8℃ (2-3℃ higher than the basic embodiment), with a temperature fluctuation range of <1.5℃. The principle is that germanium / ceramic composite powder with a particle size of 60-70nm has a higher photothermal conversion efficiency (the energy conversion rate measured in the experiment reaches 91%), and it is easier to form a uniformly dispersed infrared radiation network, reducing the risk of local overheating.

[0058] 3. Enhanced anti-inflammatory effects: The inhibition rate of inflammatory factors such as IL-6 and TNF-α is increased by 30%-45% compared to the basic embodiment. In the optimized blend of 18 essential oils, the ratio of frankincense to myrrh is adjusted to 1:1.2 (originally 1:1). Through the synergistic effect of furanoic acid and boswellic acid, the inhibition of NF-κB inflammatory pathway activity is increased by 1.7 times. Constant temperature hot compresses at 40-42℃ can promote local blood circulation (increasing blood flow by 3 times) and accelerate the metabolism of inflammatory mediators.

[0059] 4. Improved comfort and safety are achieved through the antioxidant properties of grape seed oil: increasing the dosage from 1 part to 1.2 parts effectively slows down the oxidation and decomposition of the compound essential oils, reducing the peroxide value by 62% and decreasing the release of irritating aldehydes. The cooling effect of menthol neutralizes some of the warming sensation, enhancing user comfort.

[0060] This application also provides a method for applying a plastic heat-compressing film, wherein multiple layers of the plastic heat-compressing film described above are wrapped around human joints, and the functional composition is activated by body temperature heating. Preferably, 2-5 layers are wrapped; more preferably, 3 layers are wrapped, in which the peak blood flow velocity is greatly increased, which can effectively target rheumatic arthritis.

[0061] Alternatively, multiple layers of the plastic heat-applying film described above can be wrapped around the abdomen to activate the functional composition through body heat.

[0062] The above are merely preferred embodiments of the present invention. The scope of protection of the present invention is not limited to the above embodiments. All technical solutions that fall within the scope of the present invention are within the scope of protection of the present invention.

Claims

1. A plastic heat compress film containing composite Chinese herbal essential oils, characterized in that, Includes a plastic film body and a functional composition dispersed in the plastic film body; The functional composition comprises the following components in parts by weight: 15-25 parts of traditional Chinese medicine essential oil composition, 1-2 parts of far-infrared powder, and 1.5-3 parts of penetration enhancer; The herbal essential oil composition contains at least five of the following: musk essential oil, ginger essential oil, cinnamon essential oil, clove essential oil, Clematis chinensis essential oil, Ligusticum chuanxiong essential oil, and safflower essential oil.

2. The plastic heat-compressing film of compound traditional Chinese medicine essential oil according to claim 1, characterized in that, The herbal essential oil composition comprises 1-1.5 parts of musk essential oil, 1-1.5 parts of ginger essential oil, 1-1.5 parts of cinnamon essential oil, 1-1.5 parts of clove essential oil, 1-1.5 parts of Clematis chinensis essential oil, 1-1.5 parts of Ligusticum chuanxiong essential oil, 1-1.5 parts of safflower essential oil, 1-1.5 parts of Salvia miltiorrhiza essential oil, 1-1.5 parts of Notopterygium incisum essential oil, 1-1.5 parts of Angelica pubescens essential oil, 1-1.5 parts of Artemisia argyi essential oil, 1-1.5 parts of Panax notoginseng essential oil, 1-1.5 parts of Achyranthes bidentata essential oil, 1-1.5 parts of Corydalis yanhusuo essential oil, 1-1.5 parts of Angelica sinensis essential oil, 1-1.5 parts of myrrh essential oil, 1-1.5 parts of frankincense essential oil, and 1-1.5 parts of grape seed essential oil.

3. The plastic heat-compressing film of compound traditional Chinese medicine essential oil according to claim 2, characterized in that, The functional composition also contains 1-1.5 parts of medical glycerin.

4. The plastic heat-compressing film of compound traditional Chinese medicine essential oil according to claim 1, characterized in that, The plastic film body is made of PE, PP and / or TPU.

5. The plastic heat-compressing film of the compound traditional Chinese medicine essential oil according to claim 5, characterized in that, The plastic film body comprises 70-90 parts by weight, and the functional composition comprises 10-30 parts by weight.

6. The plastic heat-compressing film of the compound Chinese herbal essential oil according to claim 1, characterized in that, The penetration enhancer is a mixture of azone and vanillyl butyl ether at a ratio of 1:0.2 to 1:

1.

7. A method for preparing a plastic heat-compressing film, characterized in that, include: S1, 10-30 parts by weight of the functional composition as described in any one of claims 1 to 6 are melt-blended and granulated with 20-40 parts by weight of plastic particles to obtain masterbatch; S2, melt-blend and granulate 40-50 parts by mass of masterbatch and 50-70 parts by mass of plastic particles to obtain film particles; S3, membrane particles are processed into thin films using a blown film machine or casting equipment; S4, slitting and packaging.

8. The method for preparing the plastic heat-compressing film according to claim 7, characterized in that, The processing temperature for melt blending and granulation is 160-200℃.

9. A method for applying heat with a plastic heat-compressing film, characterized in that, The plastic heat-coating film as described in any one of claims 1 to 6 is wrapped in multiple layers around a human joint or abdomen, and the functional composition is activated by body temperature heating.

Images