Temperature-sensitive hot compress composition based on vegetable wax-traditional Chinese medicine compounding and preparation method thereof

Abstract

The invention discloses a temperature-sensitive hot compress composition based on vegetable wax-traditional Chinese medicine compounding and a preparation method of the temperature-sensitive hot compress composition, and relates to the technical field of thermal therapy materials. The temperature-sensitive hot compress composition based on vegetable wax-traditional Chinese medicine compounding comprises the following components in parts by weight: 25-40 parts of paraffin, 10-18 parts of microcrystalline wax, 15-25 parts of a soft wax compound, 8-15 parts of mineral oil, 5-12 parts of vegetable compound oil, 10-18 parts of a traditional Chinese medicine active system and 0.3-1.5 parts of a natural preservative. The invention further provides a preparation method of the vegetable wax-traditional Chinese medicine compounded temperature-sensitive hot compress composition. The multi-stage phase change temperature zone is constructed, normal-temperature efficient loading of the traditional Chinese medicine is achieved, oxidation and deterioration of the vegetable oil are inhibited, and the problems of traditional Chinese medicine inactivation and vegetable oil oxidation caused by high-temperature preparation of traditional hot compress materials are effectively solved.

Description

Technical Field

[0001] This invention relates to the field of thermotherapy materials technology, specifically to a thermosensitive hot compress composition based on plant wax and traditional Chinese medicine, and its preparation method. Background Technology

[0002] Traditional Chinese medicine (TCM) hot compress compositions are a traditional treatment method that typically utilizes the warming effect and penetrating properties of medicinal herbs to achieve effects such as dispelling cold, relieving pain, and promoting blood circulation. However, when using traditional TCM hot compress compositions, the high temperature can easily cause skin burns. Furthermore, the use of a single paraffin base material in the preparation process of traditional TCM hot compress compositions can lead to low heat melting and a single phase transition temperature. Directly mixing TCM powders at high temperatures can cause pyrolysis of active ingredients; for example, mugwort essential oil loses more than 60% of its components at temperatures above 80℃. The excessively high precipitation rate of plant oils also reduces the product's storage stability. In addition, high-temperature oxidation of plant oils can produce aldehydes, which are irritants. Summary of the Invention

[0003] To address the aforementioned shortcomings in the existing technology, this invention provides a temperature-sensitive hot compress composition based on plant wax and traditional Chinese medicine, and its preparation method, which effectively solves the problems of inactivation of traditional Chinese medicine and oxidation of plant oil caused by high-temperature preparation of traditional hot compress materials.

[0004] To achieve the above objectives, the technical solution adopted by the present invention to solve its technical problem is: to provide a thermosensitive hot compress composition based on plant wax-traditional Chinese medicine compound, comprising the following components by weight: 25-40 parts paraffin wax, 10-18 parts microcrystalline wax, 15-25 parts soft wax complex, 8-15 parts mineral oil, 5-12 parts plant compound oil, 10-18 parts traditional Chinese medicine active system, and 0.3-1.5 parts natural preservative.

[0005] The above-mentioned thermosensitive hot compress composition based on plant wax and traditional Chinese medicine compound includes the following components by weight: 32 parts paraffin wax, 14 parts microcrystalline wax, 20 parts soft wax complex, 12 parts mineral oil, 8 parts plant compound oil, 15 parts traditional Chinese medicine active system and 0.8 parts natural preservative.

[0006] The beneficial effects of adopting the above scheme are as follows: using paraffin wax with a melting point of 50-54 ℃ as the basic thermal conductivity framework, microcrystalline wax with a melting point of 60-85 ℃ can prolong the heat release in the high-temperature range, soft wax complex can enhance the overall flexibility of the composition, mineral oil with a viscosity of 40 cSt can reduce crystal brittleness, and natural preservatives and other components have a synergistic antioxidant effect.

[0007] Furthermore, the soft wax complex comprises the following components in parts by weight: 2-4 parts beeswax, 0.5-1.5 parts candelilla wax, and 0.4-0.6 parts petrolatum.

[0008] Furthermore, the soft wax complex comprises the following components in parts by weight: 3 parts beeswax, 1 part candelilla wax, and 0.5 parts petrolatum.

[0009] The beneficial effects of adopting the above-mentioned further measures are: the three substances of beeswax, candelilla wax and petroleum jelly work together to improve flexibility, resulting in an elongation at break of ≥180%.

[0010] Furthermore, the compound vegetable oil includes the following components by weight: 4-6 parts grape seed oil, 1-3 parts jojoba oil, and 0.5-1.5 parts almond oil.

[0011] Furthermore, the plant-based blended oil comprises the following components by weight: 5 parts grapeseed oil, 2 parts jojoba oil, and 1 part almond oil.

[0012] The beneficial effects of adopting the above-mentioned further measures are that grape seed oil, jojoba oil and almond oil work synergistically to inhibit oxidation, resulting in a peroxide value ≤2.0 meq / kg.

[0013] Furthermore, the active system of traditional Chinese medicine includes the following components by weight: 2-4 parts of traditional Chinese medicine powder and 0.5-1.5 parts of traditional Chinese medicine extract.

[0014] Furthermore, the active system of traditional Chinese medicine includes the following components by weight: 3 parts of traditional Chinese medicine powder and 1 part of traditional Chinese medicine extract.

[0015] Furthermore, the Chinese medicine powder includes the following components by weight: 2-4 parts of Artemisia argyi powder, 1-3 parts of Angelica sinensis powder, 1-3 parts of Ligusticum chuanxiong powder, and 1-3 parts of Phellodendron chinense powder.

[0016] Furthermore, the Chinese medicine powder includes the following components by weight: 3 parts Artemisia argyi powder, 2 parts Angelica sinensis powder, 2 parts Ligusticum chuanxiong powder, and 2 parts Phellodendron chinense powder.

[0017] Furthermore, the Chinese medicine is further pulverized into powder using ultra-fine grinding.

[0018] Furthermore, the particle size D50 of the traditional Chinese medicine powder is ≤20 μm and the contact angle is ≥105°.

[0019] Furthermore, the herbal extract is Artemisia argyi extract.

[0020] Furthermore, the herbal extracts were extracted using subcritical water at 120 ℃ / 15 MPa.

[0021] Furthermore, the quercetin content in the Artemisia argyi extract is ≥8.5 mg / g.

[0022] Furthermore, the traditional Chinese medicine system can be used for other related prescriptions.

[0023] The beneficial effects of adopting the above-mentioned further measures are as follows: In the active system of traditional Chinese medicine, the reasonable ratio of traditional Chinese medicine powder and traditional Chinese medicine extract can synergistically improve the dissolution rate of active ingredients, with a cumulative dissolution rate of ≥75% within 5 minutes.

[0024] Furthermore, the natural preservative is camphor oil.

[0025] Furthermore, the total phenol content in natural preservatives is ≥35mg GAE / g.

[0026] The preparation method of the above-mentioned thermosensitive hot compress composition based on plant wax and traditional Chinese medicine includes the following steps: S1. Mix paraffin wax, microcrystalline wax and mineral oil and melt them. Then add soft wax complex and stir. Then add plant compound oil and stir homogenize to obtain wax oil matrix. S2. Mix the Chinese herbal powder and extract with the wax oil matrix obtained in step S1, cool it down, add natural preservatives, degas under vacuum, and then cast it into shape to obtain a temperature-sensitive hot compress composition based on plant wax and Chinese herbal compound.

[0027] Further, in step S1, the mixture is melted at 59-61 ℃, then stirred at 62-64 ℃, and then homogenized at 64-65 ℃.

[0028] Furthermore, in step S1, the mixture is melted at 60 °C, then stirred at 63 °C, and then homogenized at 65 °C.

[0029] Furthermore, in step S2, the mixture is prepared at 51-53 °C.

[0030] Furthermore, in step S2, the mixture is prepared at 52 °C.

[0031] Furthermore, in step S2, the shear rate during mixing is 700-900 rpm.

[0032] Furthermore, in step S2, the shear rate during mixing is 800 rpm.

[0033] Furthermore, in step S2, the temperature is lowered to 44-46 ℃.

[0034] Furthermore, in step S2, the temperature is lowered to 45 ℃.

[0035] Furthermore, in step S2, vacuum degassing is performed at -0.09 to -0.07 MPa.

[0036] Furthermore, in step S2, vacuum degassing is performed at -0.08 MPa.

[0037] In summary, the present invention has the following beneficial effects: 1. This invention employs a low-temperature preparation process. During the premixing of the wax oil matrix (≤65 ℃), loading of traditional Chinese medicine (52±1 ℃), and addition of essential oil (45 ℃), the temperature remains ≤65 ℃. This cold processing technique achieves a 93% retention rate of Artemisia argyi essential oil, 120% higher than the high-temperature process. Adding camphor oil after cooling to 45 ℃ retains volatile antibacterial components (1,8-cineole retention rate 91%). Furthermore, the ultrafine powder of traditional Chinese medicine (D 50≤20 μm) and subcritical water extract (quercetin ≥8.5 mg / g) are compounded in a specific ratio, achieving an active ingredient dissolution rate ≥75% within 5 minutes. The hydrophobic properties of the traditional Chinese medicine powder (contact angle ≥105°) reduce surface energy (surface tension ≤28 mN / m), solving the residue problem.

[0038] 2. This invention constructs a multi-stage phase transition temperature zone (45-60 ℃) to enhance the duration of thermal activity. The combination of paraffin wax (50-54 ℃) and microcrystalline wax (60-85 ℃) has a synergistic effect, increasing the duration of thermal activity by 150%. The soft wax composite achieves an elongation at break of ≥180%, solving the brittleness problem of traditional materials. The combination of beeswax and candelilla wax synergistically enhances adhesion (cohesive work ≥18J / m). 2 And increase the melting point (ΔT↑5 ℃).

[0039] 3. In the compound plant oil, grape seed oil, jojoba oil and almond oil are combined in a specific ratio to synergistically resist oxidation, resulting in a peroxide value ≤2.0 meq / kg. Camphor oil and traditional Chinese medicine powder have a synergistic antibacterial effect, with an inhibition zone of ≥18 mm against Staphylococcus aureus. Detailed Implementation

[0040] The principles and features of this invention are described below. The examples given are for illustrative purposes only and are not intended to limit the scope of the invention. Unless otherwise specified in the examples, conventional conditions or conditions recommended by the manufacturer should be followed. Reagents or instruments whose manufacturers are not specified are all commercially available products.

[0041] Example 1 The thermosensitive hot compress composition based on plant wax and traditional Chinese medicine compound includes the following components by weight: 32 parts paraffin wax, 14 parts microcrystalline wax, 20 parts soft wax complex, 12 parts mineral oil, 8 parts plant compound oil, 15 parts traditional Chinese medicine active system and 0.8 parts natural preservative (camphor oil).

[0042] The above-mentioned soft wax complex includes the following components in parts by weight: 3 parts beeswax, 1 part candelilla wax, and 0.5 parts petrolatum.

[0043] The above-mentioned compound vegetable oil comprises the following components by weight: 5 parts grape seed oil, 2 parts jojoba oil, and 1 part almond oil.

[0044] The above-mentioned active system of traditional Chinese medicine includes the following components by weight: 3 parts of traditional Chinese medicine powder and 1 part of traditional Chinese medicine extract (Artemisia argyi extract).

[0045] The above-mentioned Chinese herbal powder includes the following components by weight: 3 parts of Artemisia argyi powder, 2 parts of Angelica sinensis powder, 2 parts of Ligusticum chuanxiong powder, and 2 parts of Phellodendron chinense powder.

[0046] The preparation method of the above-mentioned thermosensitive hot compress composition based on plant wax and traditional Chinese medicine includes the following steps: S1. Mix paraffin wax, microcrystalline wax and mineral oil and melt at 60 ℃. Add beeswax, candelilla wax and petrolatum and stir at 63 ℃. Then add grapeseed oil, jojoba oil and almond oil and homogenize at 65 ℃ to obtain the wax oil matrix. S2. Artemisia argyi, Angelica sinensis, Ligusticum chuanxiong, and Phellodendron chinense are ultra-finely pulverized to obtain traditional Chinese medicine powder. The particle size D50 of the above traditional Chinese medicine powder is ≤20μm and the contact angle is ≥105°. Artemisia argyi is extracted with subcritical water at 120 ℃ / 15 MPa to obtain Artemisia argyi extract. The quercetin content in the above Artemisia argyi extract is ≥8.5 mg / g. The traditional Chinese medicine powder and Artemisia argyi extract are mixed with the wax oil matrix obtained in step S1 at 52 ℃ with a shear rate of 800 rpm. The mixture is cooled to 45 ℃, and camphor oil is added. The total phenol content in the above camphor oil is ≥35 mgGAE / g. After vacuum degassing at -0.08 MPa, the mixture is cast into shape to obtain a thermosensitive hot compress composition based on plant wax and traditional Chinese medicine compound.

[0047] Example 2 The thermosensitive hot compress composition based on plant wax and traditional Chinese medicine compound includes the following components by weight: 25 parts paraffin wax, 10 parts microcrystalline wax, 15 parts soft wax complex, 8 parts mineral oil, 5 parts plant compound oil, 10 parts traditional Chinese medicine active system and 0.3 parts natural preservative (camphor oil).

[0048] The above-mentioned soft wax complex includes the following components in parts by weight: 2 parts beeswax, 0.5 parts candelilla wax, and 0.4 parts petrolatum.

[0049] The above-mentioned compound vegetable oil includes the following components by weight: 4 parts grape seed oil, 1 part jojoba oil, and 0.5 parts almond oil.

[0050] The above-mentioned active system of traditional Chinese medicine includes the following components by weight: 2 parts of traditional Chinese medicine powder and 0.5 parts of traditional Chinese medicine extract (Artemisia argyi extract).

[0051] The above-mentioned Chinese herbal powder includes the following components by weight: 2 parts of Artemisia argyi powder, 1 part of Angelica sinensis powder, 1 part of Ligusticum chuanxiong powder, and 1 part of Phellodendron chinense powder.

[0052] The preparation method of the above-mentioned thermosensitive hot compress composition based on plant wax and traditional Chinese medicine includes the following steps: S1. After mixing paraffin wax, microcrystalline wax and mineral oil, melt at 59 ℃, add beeswax, candelilla wax and petrolatum and stir at 62 ℃, then add grapeseed oil, jojoba oil and almond oil and homogenize at 64 ℃ to obtain wax oil matrix; S2. Artemisia argyi, Angelica sinensis, Ligusticum chuanxiong, and Phellodendron chinense are ultra-finely pulverized to obtain traditional Chinese medicine powder. The particle size D50 of the above traditional Chinese medicine powder is ≤20μm and the contact angle is ≥105°. Artemisia argyi is extracted with subcritical water at 120 ℃ / 15 MPa to obtain Artemisia argyi extract. The quercetin content in the above Artemisia argyi extract is ≥8.5 mg / g. The traditional Chinese medicine powder and Artemisia argyi extract are mixed with the wax oil matrix obtained in step S1 at 51 ℃ with a shear rate of 700 rpm. The mixture is cooled to 44 ℃, and camphor oil is added. The total phenol content in the above camphor oil is ≥35 mgGAE / g. After vacuum degassing at -0.09 MPa, the mixture is cast into shape to obtain a thermosensitive hot compress composition based on plant wax and traditional Chinese medicine compound.

[0053] Example 3 The thermosensitive hot compress composition based on plant wax and traditional Chinese medicine compound includes the following components by weight: 40 parts paraffin wax, 18 parts microcrystalline wax, 25 parts soft wax complex, 15 parts mineral oil, 12 parts plant compound oil, 18 parts traditional Chinese medicine active system, and 1.5 parts natural preservative (camphor oil).

[0054] The aforementioned soft wax complex comprises the following components in parts by weight: 4 parts beeswax, 1.5 parts candelilla wax, and 0.6 parts petrolatum.

[0055] The above-mentioned compound vegetable oil includes the following components by weight: 6 parts grape seed oil, 3 parts jojoba oil, and 1.5 parts almond oil.

[0056] The above-mentioned active system of traditional Chinese medicine includes the following components by weight: 4 parts of traditional Chinese medicine powder and 1.5 parts of traditional Chinese medicine extract (Artemisia argyi extract).

[0057] The above-mentioned Chinese herbal powder includes the following components by weight: 4 parts of Artemisia argyi powder, 3 parts of Angelica sinensis powder, 3 parts of Ligusticum chuanxiong powder, and 3 parts of Phellodendron chinense powder.

[0058] The preparation method of the above-mentioned thermosensitive hot compress composition based on plant wax and traditional Chinese medicine includes the following steps: S1. Mix paraffin wax, microcrystalline wax and mineral oil and melt at 61 °C. Add beeswax, candelilla wax and petrolatum and stir at 64 °C. Then add grapeseed oil, jojoba oil and almond oil and homogenize at 65 °C to obtain the wax oil matrix. S2. Artemisia argyi, Angelica sinensis, Ligusticum chuanxiong, and Phellodendron chinense are ultra-finely pulverized to obtain traditional Chinese medicine powder. The particle size D50 of the above traditional Chinese medicine powder is ≤20μm and the contact angle is ≥105°. Artemisia argyi is extracted with subcritical water at 120 ℃ / 15 MPa to obtain Artemisia argyi extract. The quercetin content in the above Artemisia argyi extract is ≥8.5 mg / g. The traditional Chinese medicine powder and Artemisia argyi extract are mixed with the wax oil matrix obtained in step S1 at 53 ℃ with a shear rate of 900 rpm. The mixture is cooled to 46 ℃, and camphor oil is added. The total phenol content in the above camphor oil is ≥35 mgGAE / g. After vacuum degassing at -0.07 MPa, the mixture is cast into shape to obtain a thermosensitive hot compress composition based on plant wax and traditional Chinese medicine compound.

[0059] Comparative Example 1 The difference between Comparative Example 1 and Example 1 is that the Chinese medicine powder in Comparative Example 1 contains only Artemisia argyi powder and does not contain Angelica sinensis, Ligusticum chuanxiong, or Phellodendron chinense powder.

[0060] Comparative Example 2 The difference between Comparative Example 2 and Example 1 is that the soft wax complex in Comparative Example 2 contains only beeswax and does not contain candelilla wax or petrolatum.

[0061] Comparative Example 3 The difference between Comparative Example 3 and Example 1 is that in step S2 of Comparative Example 3, the traditional Chinese medicine powder and Artemisia argyi extract are mixed with the wax oil matrix at 80 °C.

[0062] Experimental Example 1 To evaluate the performance and safety of the thermosensitive hot compress composition based on plant wax and traditional Chinese medicine provided by this invention under storage (room temperature) and use (35-45℃) conditions, a three-dimensional evaluation model is provided, as shown in Tables 1-3, corresponding to the physical performance dimension (weight: 40%), appearance characteristics dimension (weight: 20%), and user experience dimension (weight: 40%), respectively.

[0063] Table 1 Physical Performance Dimensions

[0064] Table 2 Appearance Characteristics Dimensions

[0065] Table 3 User Experience Dimensions

[0066] (1) Comparing some performance of Example 1 with Comparative Examples 1-3, the results are shown in Table 4.

[0067] Table 4. Partial Performance Comparison

[0068] As shown in Table 4, the retention rate of Artemisia argyi essential oil in Example 1 reached 93%, which is 35-120% higher than that of the comparative example; the heat duration at 45-50℃ was extended to 25 min, an improvement of 150%; the antibacterial effect of Example 1 was higher than that of the comparative example; the spreading efficiency was improved by 185%; the skin oiliness was reduced by 68%, and the oiliness was ≤3%, which is much lower than that of the comparative example; the dissolution efficiency reached 75% in 5 minutes. It can be seen that Example 1 shows comprehensive advantages in product performance.

[0069] (2) The evaluation dimensions of the thermosensitive hot compress composition based on plant wax and traditional Chinese medicine prepared in Example 1 are compared with those of commercially available traditional paraffin hot compress plasters, as shown in Table 5.

[0070] Table 5 Comparison Results of Evaluation Dimensions

[0071] As shown in Table 5, the thermosensitive hot compress composition based on plant wax and traditional Chinese medicine provided by the present invention has a 185% improvement in spreadability and a 118% improvement in heat duration compared with commercially available traditional paraffin hot compress paste. In terms of skin stickiness, the greasiness is reduced by 68%.

[0072] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A thermosensitive hot compress composition based on plant wax and traditional Chinese medicine compound, characterized in that, It includes the following components by weight: 25-40 parts paraffin wax, 10-18 parts microcrystalline wax, 15-25 parts soft wax complex, 8-15 parts mineral oil, 5-12 parts plant compound oil, 10-18 parts traditional Chinese medicine active system, and 0.3-1.5 parts natural preservative.

2. The thermosensitive hot compress composition based on plant wax and traditional Chinese medicine compound as described in claim 1, characterized in that, It includes the following components by weight: 32 parts paraffin wax, 14 parts microcrystalline wax, 20 parts soft wax complex, 12 parts mineral oil, 8 parts plant compound oil, 15 parts traditional Chinese medicine active system, and 0.8 parts natural preservative.

3. The thermosensitive hot compress composition based on plant wax and traditional Chinese medicine compound as described in claim 1 or 2, characterized in that, The soft wax complex comprises the following components in parts by weight: 2-4 parts beeswax, 0.5-1.5 parts candelilla wax, and 0.4-0.6 parts petrolatum.

4. The thermosensitive hot compress composition based on plant wax and traditional Chinese medicine compound as described in claim 1 or 2, characterized in that, The compound plant oil comprises the following components by weight: 4-6 parts grape seed oil, 1-3 parts jojoba oil, and 0.5-1.5 parts almond oil.

5. The thermosensitive hot compress composition based on plant wax and traditional Chinese medicine compound as described in claim 1 or 2, characterized in that, The active system of traditional Chinese medicine includes the following components by weight: 2-4 parts of traditional Chinese medicine powder and 0.5-1.5 parts of traditional Chinese medicine extract.

6. The thermosensitive hot compress composition based on plant wax and traditional Chinese medicine compound as described in claim 1 or 2, characterized in that, The natural preservative is camphor oil.

7. The method for preparing the thermosensitive hot compress composition based on plant wax and traditional Chinese medicine compound according to any one of claims 1-6, characterized in that, Includes the following steps: S1. Mix paraffin wax, microcrystalline wax and mineral oil and melt them. Then add soft wax complex and stir. Then add plant compound oil and stir homogenize to obtain wax oil matrix. S2. Mix the Chinese herbal powder and extract with the wax oil matrix obtained in step S1, cool it down, add natural preservatives, degas under vacuum, and then cast it into shape to obtain a temperature-sensitive hot compress composition based on plant wax and Chinese herbal compound.

8. The preparation method of the thermosensitive hot compress composition based on plant wax and traditional Chinese medicine compound as described in claim 7, characterized in that, In step S1, the mixture is melted at 59-61 ℃, then stirred at 62-64 ℃, and then homogenized at 64-66 ℃.

9. The preparation method of the thermosensitive hot compress composition based on plant wax and traditional Chinese medicine compound as described in claim 7, characterized in that, In step S2, the shear rate during mixing is 700-900 rpm.

10. The preparation method of the thermosensitive hot compress composition based on plant wax and traditional Chinese medicine compound as described in claim 7, characterized in that, In step S2, the temperature is lowered to 44-46 ℃.

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