Non-invasive neural feedback regulation and control equipment for deep brain stimulation

Abstract

The invention is applicable to the technical field of current regulation and control, and provides non-invasive neural feedback regulation and control equipment for deep brain stimulation, which comprises an upper computer, a processor, a neural current regulation and control module, an electroencephalogram signal acquisition module and an acquisition and regulation and control change-over switch, the upper computer is connected with the processor, the processor is connected with the neural current regulation and control module, the neural current regulation and control module is connected with the acquisition and regulation and control change-over switch, the acquisition and regulation and control change-over switch is connected with the electroencephalogram signal acquisition module, and the electroencephalogram signal acquisition module is connected with the processor. According to the application, a multipath isolation and time division multiplexing technology is adopted, deep brain precise stimulation and real-time monitoring are realized, crosstalk and overvoltage can be effectively prevented, and the treatment safety and curative effect are improved.

Description

Technical Field

[0001] This application belongs to the field of current regulation technology, and in particular relates to a non-invasive neurofeedback regulation device for deep brain stimulation. Background Technology

[0002] In the treatment of neurological and psychiatric disorders, neuromodulation is often used to target the lesion area. Commonly used modulation methods include tDCS (telectrical direct current stimulation) and TMS (thermal direct current stimulation). Electrical stimulation is commonly used non-invasively to treat diseases caused by functional cortical damage (e.g., aphasia, dysphagia) and invasively to treat motor dysfunction (e.g., Parkinson's disease, dystonia). Magnetic stimulation is commonly used non-invasively to treat cortical developmental disorders and psychiatric disorders. While both electrical and magnetic stimulation can address some functional cortical-related diseases in non-invasive neuromodulation, if the lesion is located below the cortex, such as in the hypothalamus (which contains many disease-related functional subregions), existing non-invasive modulation methods may not be able to modulate specific deep brain regions.

[0003] Current technologies employ traditional non-invasive electromagnetic stimulation methods, but their current output is affected by the human body's load and multiple signals are prone to crosstalk, resulting in the inability to accurately focus on deep brain target areas and issues such as signal interference and safety hazards. Summary of the Invention

[0004] This application provides a non-invasive neurofeedback modulation device for deep brain stimulation, which can solve the problems of current related technologies using traditional non-invasive electromagnetic stimulation methods, where the current output is affected by the human body load and multiple signals are prone to crosstalk, resulting in the inability to accurately focus on the deep brain target area and the existence of signal acquisition interference and safety hazards.

[0005] This application provides a non-invasive neurofeedback modulation device for deep brain stimulation, including: a host computer, a processor, a neural current modulation module, an electroencephalogram (EEG) signal acquisition module, and an acquisition and modulation switching switch; the host computer is connected to the processor, the processor is connected to the neural current modulation module, the neural current modulation module is connected to the acquisition and modulation switching switch, the acquisition and modulation switching switch is connected to the EEG signal acquisition module, and the EEG signal acquisition module is connected to the processor. The host computer is used to set the control parameters and send them to the processor; The processor is used to process the modulation parameters, generate control signals, and send the control signals to the neural current modulation module. A neural current modulation module is used to generate a stimulation current signal based on a control signal during the stimulation phase. The EEG signal acquisition module is used to acquire EEG signals from the scalp during the acquisition phase and send the EEG signals to the processor; The acquisition and control switching switch is used to set the device to the stimulation phase or the acquisition phase using the time-division multiplexing method.

[0006] In one possible implementation of the first aspect, the aforementioned neural current regulation module includes a current intensity control circuit and a voltage-controlled current source, wherein the current intensity control circuit is connected to the voltage-controlled current source; the current intensity control circuit includes a first digital isolator, a first digital-to-analog converter, a first amplifier, and a filter, wherein the first digital isolator is connected to the first digital-to-analog converter, the first digital-to-analog converter is connected to the first amplifier, and the first amplifier is connected to the filter; The current intensity control circuit is used to process the control signal in sequence through a first digital isolator, a first digital-to-analog converter, a first amplifier, a filter, and a voltage-controlled current source during the stimulation phase, and then generate a stimulation current signal after electromagnetic interference filtering.

[0007] Optionally, in another possible implementation of the first aspect, the aforementioned neural current regulation module further includes a power isolation and boost circuit, which is connected to a voltage-controlled current source. Power isolation and boost circuitry is used to provide power to the neural current regulation module.

[0008] Optionally, in another possible implementation of the first aspect, the power isolation and boost circuit includes a power isolation circuit and a boost circuit, with the power isolation circuit connected to the boost circuit; the power isolation circuit includes a power supply, a DC / DC driver U1, and a transformer T1; the boost circuit includes n capacitors Cn, n capacitors Cn', and n rectifiers Bn, where n is a positive integer. The power supply is connected to the input terminal of DC / DC driver U1, and the output terminal of DC / DC driver U1 is connected to the input terminal of transformer T1. The output terminal of transformer T1 is connected to the AC+ and AC- terminals of rectifier B1 through capacitors C1 and C1', respectively. The DC- terminal of rectifier B1 is connected to ground, the DC+ terminal of rectifier B1 is connected to the DC- terminal of rectifier B2, the AC+ terminal of rectifier B1 is connected to the AC+ terminal of rectifier B2 through capacitor C2, and the AC- terminal of rectifier B1 is connected to the AC- terminal of rectifier B2 through capacitor C2', thus superimposing the power supply onto rectifier Bn.

[0009] Optionally, in another possible implementation of the first aspect, the aforementioned neural current regulation module further includes a monitoring circuit, the processor is connected to the monitoring circuit, and the monitoring circuit is connected to a voltage-controlled current source; the monitoring circuit includes a load, a second amplifier, a second digital-to-analog converter, and a second digital isolator; the load is connected to the second amplifier, the second amplifier is connected to the second digital-to-analog converter, and the second digital-to-analog converter is connected to the second digital isolator; The monitoring circuit is used to process the voltage signal generated by connecting the output terminal of the voltage-controlled current source to the load through the second amplifier, the second digital-to-analog converter and the second digital isolator in sequence, and then send it to the processor.

[0010] Optionally, in another possible implementation of the first aspect, the above-mentioned EEG signal acquisition module includes a third amplifier, a third digital-to-analog converter, a third digital isolator, and a power isolation circuit; the power isolation circuit is connected to the third amplifier, the third digital-to-analog converter, and the third digital isolator respectively; the acquisition and control switching switch is connected to the third amplifier; the third amplifier is connected to the third digital-to-analog converter; the third digital-to-analog converter is connected to the third digital isolator; and the third digital isolator is connected to the processor.

[0011] The technical solution of this application includes a host computer, a processor, a neural current modulation module, an electroencephalogram (EEG) signal acquisition module, and an acquisition and modulation switching switch. The host computer is connected to the processor, the processor is connected to the neural current modulation module, the neural current modulation module is connected to the acquisition and modulation switching switch, the acquisition and modulation switching switch is connected to the EEG signal acquisition module, and the EEG signal acquisition module is connected to the processor. The host computer is used to set modulation parameters and send them to the processor; the processor is used to process the modulation parameters, generate control signals, and send the control signals to the neural current modulation module; the neural current modulation module is used to generate stimulation current signals according to the control signals during the stimulation phase; the EEG signal acquisition module is used to acquire EEG signals from the scalp during the acquisition phase and send the EEG signals to the processor; the acquisition and modulation switching switch is used to set the device to the stimulation phase or the acquisition phase using a time-division multiplexing method. This application uses multi-channel isolation and time-division multiplexing technology to achieve precise deep brain stimulation and real-time monitoring, effectively preventing crosstalk and overvoltage, and improving treatment safety and efficacy. Attached Figure Description

[0012] To more clearly illustrate the technical solutions in the embodiments of this application, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0013] Figure 1 This is a schematic diagram of the structure of a non-invasive neurofeedback modulation device for deep brain stimulation provided in an embodiment of this application; Figure 2 This is a schematic diagram of the structure of a neural current regulation module provided in one embodiment of this application; Figure 3 This is a schematic diagram of the structure of a neural current regulation module provided in another embodiment of this application; Figure 4This is a schematic diagram of the power isolation and boost circuit provided in one embodiment of this application; Figure 5 This is a schematic diagram of the structure of a neural current regulation module provided in another embodiment of this application; Figure 6 This is a schematic diagram of the structure of an EEG signal acquisition module provided in one embodiment of this application. Detailed Implementation

[0014] In the following description, specific details such as particular system architectures and techniques are set forth for illustrative purposes and not for limitation, in order to provide a thorough understanding of the embodiments of this application. However, those skilled in the art will understand that this application may also be implemented in other embodiments without these specific details. In other instances, detailed descriptions of well-known systems, apparatuses, circuits, and methods have been omitted so as not to obscure the description of this application with unnecessary detail.

[0015] It should be understood that, when used in this application specification and the appended claims, the term "comprising" indicates the presence of the described features, integrals, steps, operations, elements and / or components, but does not exclude the presence or addition of one or more other features, integrals, steps, operations, elements, components and / or a collection thereof.

[0016] It should also be understood that the term “and / or” as used in this application specification and the appended claims means any combination of one or more of the associated listed items and all possible combinations, and includes such combinations.

[0017] As used in this application specification and the appended claims, the term "if" may be interpreted, depending on the context, as "when," "once," "in response to determination," or "in response to detection." Similarly, the phrase "if determined" or "if detected [the described condition or event]" may be interpreted, depending on the context, as meaning "once determined," "in response to determination," "once detected [the described condition or event]," or "in response to detection [the described condition or event]."

[0018] Furthermore, in the description of this application and the appended claims, the terms "first," "second," "third," etc., are used only to distinguish descriptions and should not be construed as indicating or implying relative importance.

[0019] References to "one embodiment" or "some embodiments" as described in this specification mean that one or more embodiments of this application include a specific feature, structure, or characteristic described in connection with that embodiment. Therefore, the phrases "in one embodiment," "in some embodiments," "in other embodiments," "in still other embodiments," etc., appearing in different parts of this specification do not necessarily refer to the same embodiment, but rather mean "one or more, but not all, embodiments," unless otherwise specifically emphasized. The terms "comprising," "including," "having," and variations thereof mean "including but not limited to," unless otherwise specifically emphasized.

[0020] The following is a detailed description of a non-invasive neurofeedback modulation device for deep brain stimulation provided in this application, with reference to the accompanying drawings.

[0021] Figure 1 This illustration shows a structural schematic diagram of a non-invasive neurofeedback modulation device for deep brain stimulation provided in an embodiment of this application.

[0022] like Figure 1 As shown, the non-invasive neurofeedback modulation device 100 for deep brain stimulation includes: a host computer 101, a processor 102, a neural current modulation module 103, an electroencephalogram (EEG) signal acquisition module 104, and an acquisition and modulation switching switch 105; the host computer 101 is connected to the processor 102, the processor 102 is connected to the neural current modulation module 103, the neural current modulation module 103 is connected to the acquisition and modulation switching switch 105, the acquisition and modulation switching switch 105 is connected to the EEG signal acquisition module 104, and the EEG signal acquisition module 104 is connected to the processor 102; The host computer 101 is used to set the control parameters and send them to the processor 102; The processor 102 is used to process the regulation parameters, generate control signals, and send the control signals to the neural current regulation module 103; The neural current modulation module 103 is used to generate a stimulation current signal according to the control signal during the stimulation phase. The EEG signal acquisition module 104 is used to acquire EEG signals from the scalp during the acquisition phase and send the EEG signals to the processor 102. The acquisition and control switching switch 105 is used to set the device to the stimulation phase or the acquisition phase using the time-division multiplexing method.

[0023] Furthermore, in the embodiments of this application, such as Figure 2 The schematic diagram of the neural current modulation module shown above, the neural current modulation module 103, includes: The current intensity control circuit 1031 and the voltage-controlled current source 1032 are connected to the voltage-controlled current source 1032. The current intensity control circuit 1031 includes a first digital isolator, a first digital-to-analog converter, a first amplifier, and a filter. The first digital isolator is connected to the first digital-to-analog converter, the first digital-to-analog converter is connected to the first amplifier, and the first amplifier is connected to the filter. The current intensity control circuit 1031 is used to process the control signal in sequence through a first digital isolator, a first digital-to-analog converter, a first amplifier, a filter, and a voltage-controlled current source during the stimulation phase, and then generate a stimulation current signal after electromagnetic interference filtering.

[0024] In this embodiment, the processor's control signal is connected to the digital input of the first digital-to-analog converter (DAC) via a first digital isolator. The DAC outputs a small voltage signal based on the parameters of the control signal. This output signal is then connected to the input of a first amplifier to amplify the voltage signal. The output of the first amplifier is connected to the input of a filter for filtering, removing voltage steps caused by the communication gap between the processor and the DAC and the DAC's setup time, as well as high-frequency oscillations caused by power supply ripple. The filter outputs a high-quality voltage for use by a voltage-controlled current source.

[0025] Furthermore, in the embodiments of this application, such as Figure 3 The schematic diagram of the neural current modulation module shown above, the aforementioned neural current modulation module 103, further includes: The power isolation and boost circuit 1033 is connected to the voltage-controlled current source 1032. Power isolation and boost circuitry is used to provide power to the neural current regulation module.

[0026] In this application embodiment, during interference modulation, the multiple current source signals participating in the interference modulation need to be isolated from each other and not interfere with each other in order to form a modulation signal that can act on the target area in the deep brain. In terms of implementation, output signal isolation is required to ensure the isolation requirements of the current signal. Signal isolation at the signal output end often attenuates the strength of the output signal. This application mainly solves the output signal isolation and high voltage requirements by power isolation followed by voltage boosting. Power isolation boosting designs often involve passing a DC voltage signal through a power isolator and then boosting it through a boost chip to obtain the voltage required by the device, or obtaining the required high voltage through rectification of AC 220V by an isolation transformer. The former method results in a smaller operating current, while the latter method makes the device too bulky to accommodate multiple channels. This application designs a method that uses a push-pull DC / DC driver, a transformer (which also provides isolation), and then multiple stages of superimposed full-bridge rectification to obtain the ideal high voltage. This boost circuit has the advantages of high voltage, high current, and small size.

[0027] Furthermore, in the embodiments of this application, such as Figure 4 The schematic diagram of the power isolation and boost circuit shown above, the power isolation and boost circuit 1033, includes: The circuit consists of a power isolation circuit and a boost circuit. The power isolation circuit is connected to the boost circuit. The power isolation circuit includes a power supply, a DC / DC driver U1, and a transformer T1. The boost circuit includes n capacitors Cn, n capacitors Cn', and n rectifiers Bn, where n is a positive integer. The power supply is connected to the input terminal of DC / DC driver U1, and the output terminal of DC / DC driver U1 is connected to the input terminal of transformer T1. The output terminal of transformer T1 is connected to the AC+ and AC- terminals of rectifier B1 through capacitors C1 and C1', respectively. The DC- terminal of rectifier B1 is connected to ground, the DC+ terminal of rectifier B1 is connected to the DC- terminal of rectifier B2, the AC+ terminal of rectifier B1 is connected to the AC+ terminal of rectifier B2 through capacitor C2, and the AC- terminal of rectifier B1 is connected to the AC- terminal of rectifier B2 through capacitor C2', thus superimposing the power supply onto rectifier Bn.

[0028] Furthermore, in the embodiments of this application, such as Figure 5 The schematic diagram of the neural current modulation module shown above, the aforementioned neural current modulation module 103, further includes: The monitoring circuit 1034 is connected to the processor 102, and the monitoring circuit 1034 is connected to the voltage-controlled current source 1032. The monitoring circuit 1034 includes a load, a second amplifier, a second digital-to-analog converter, and a second digital isolator. The load is connected to the second amplifier, the second amplifier is connected to the second digital-to-analog converter, and the second digital-to-analog converter is connected to the second digital isolator. The monitoring circuit is used to process the voltage signal generated by connecting the output terminal of the voltage-controlled current source to the load through the second amplifier, the second digital-to-analog converter and the second digital isolator in sequence, and then send it to the processor.

[0029] In this embodiment, the output terminal of the voltage-controlled current source is connected to the load to generate a voltage signal. The voltage signal is amplified and then converted into a digital signal by an analog-to-digital converter and transmitted to the processor via a digital isolator. The processor identifies the strength of the voltage signal to determine the risk of electric shock to the operator and user, and controls the analog-to-digital converter to stop the signal output.

[0030] Furthermore, in the embodiments of this application, such as Figure 6 The schematic diagram of the EEG signal acquisition module shown above, the EEG signal acquisition module 104, includes: The system comprises a third amplifier, a third digital-to-analog converter, a third digital isolator, and a power isolation circuit. The power isolation circuit is connected to the third amplifier, the third digital-to-analog converter, and the third digital isolator. The acquisition and control switch 105 is connected to the third amplifier, the third amplifier is connected to the third digital-to-analog converter, the third digital-to-analog converter is connected to the third digital isolator, and the third digital isolator is connected to the processor 102.

[0031] In this embodiment, by designing power isolation and digital signal isolation for the acquisition and control systems respectively, and by using a switching switch to avoid the acquisition and control from acting on the same human body point at the same time, the system can still normally acquire microvolt-level EEG signals while performing high current (voltage in the range of tens to hundreds of volts) control.

[0032] The power supply used for EEG signal acquisition is isolated within the device. The EEG signal acquisition module and processor communicate via a digital isolator. The ground and power supply within this module do not share a common voltage reference with other modules within the device. Similarly, for current-controlled signals, the operating power supply is isolated within the device. The current source generation circuit and processor communicate via a digital isolator. The ground and power supply within this module also do not share a common voltage reference with other modules within the device. When applied to the same human body location, a channel switching switch is used to prevent short circuits between the acquisition circuit and the current control circuit, thus avoiding the formation of a common voltage reference.

[0033] This application provides a non-invasive neurofeedback modulation device for deep brain stimulation. It can achieve multi-channel, mutually isolated current modulation signals at high voltages (tens to hundreds of volts). During multi-channel modulation, the channels do not interfere with each other. When placed on the scalp, it can form interference signals deep within the brain, acting on the target area. The device monitors the contact impedance between the output terminal and the human body in real time. When high impedance (corresponding to high voltage) is detected, it alerts the user or operator and stops the current signal output, avoiding the risk of electric shock. During EEG acquisition, the acquisition circuit and stimulation circuit are power-isolated, with no common voltage reference, ensuring that the weak EEG signals are not affected by high-voltage modulation signals. When acquisition and modulation are applied to the same body location, a switch automatically switches between them to prevent short circuits between the acquisition and modulation circuits, thus improving signal quality.

[0034] In the embodiments provided in this application, it should be understood that the disclosed devices / terminal equipment and methods can be implemented in other ways. For example, the device / terminal equipment embodiments described above are merely illustrative. For instance, the division of modules or units is only a logical functional division, and in actual implementation, there may be other division methods. For example, multiple units or components may be combined or integrated into another system, or some features may be ignored or not executed. Furthermore, the displayed or discussed mutual coupling or direct coupling or communication connection may be through some interfaces; the indirect coupling or communication connection between devices or units may be electrical, mechanical, or other forms.

[0035] The units described as separate components may or may not be physically separate. The components shown as units may or may not be physical units; that is, they may be located in one place or distributed across multiple network units. Some or all of the units can be selected to achieve the purpose of this embodiment according to actual needs.

[0036] The above-described embodiments are only used to illustrate the technical solutions of this application, and are not intended to limit them. Although this application has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some of the technical features. Such modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the spirit and scope of the technical solutions of the embodiments of this application, and should all be included within the protection scope of this application.

Claims

1. A non-invasive neurofeedback modulation device for deep brain stimulation, characterized in that, The device includes a host computer, a processor, a neural current modulation module, an electroencephalogram (EEG) signal acquisition module, and an acquisition and modulation switching switch; the host computer is connected to the processor, the processor is connected to the neural current modulation module, the neural current modulation module is connected to the acquisition and modulation switching switch, the acquisition and modulation switching switch is connected to the EEG signal acquisition module, and the EEG signal acquisition module is connected to the processor; The host computer is used to set the control parameters and send them to the processor; The processor is used to process the modulation parameters, generate a control signal, and send the control signal to the neural current modulation module. The neural current modulation module is used to generate a stimulation current signal according to the control signal during the stimulation phase. The EEG signal acquisition module is used to acquire EEG signals from the scalp during the acquisition phase and send the EEG signals to the processor. The acquisition and control switching switch is used to set the device to either the stimulation phase or the acquisition phase using a time-division multiplexing method.

2. The device as described in claim 1, characterized in that, The neural current regulation module includes a current intensity control circuit and a voltage-controlled current source. The current intensity control circuit is connected to the voltage-controlled current source. The current intensity control circuit includes a first digital isolator, a first digital-to-analog converter, a first amplifier, and a filter. The first digital isolator is connected to the first digital-to-analog converter, the first digital-to-analog converter is connected to the first amplifier, and the first amplifier is connected to the filter. The current intensity control circuit is used to process the control signal sequentially through the first digital isolator, the first digital-to-analog converter, the first amplifier, the filter, and the voltage-controlled current source during the stimulation phase, and then generate the stimulation current signal after electromagnetic interference filtering.

3. The device as described in claim 2, characterized in that, The neural current regulation module also includes a power isolation and boost circuit, which is connected to the voltage-controlled current source; The power isolation and boost circuit is used to provide power to the neural current regulation module.

4. The device as described in claim 3, characterized in that, The power isolation and boost circuit includes a power isolation circuit and a boost circuit, wherein the power isolation circuit is connected to the boost circuit; the power isolation circuit includes a power supply, a DC / DC driver U1, and a transformer T1; the boost circuit includes n capacitors Cn, n capacitors Cn', and n rectifiers Bn, where n is a positive integer. The power supply is connected to the input terminal of the DC / DC driver U1, and the output terminal of the DC / DC driver U1 is connected to the input terminal of the transformer T1. The output terminal of the transformer T1 is connected to the AC+ and AC- terminals of the rectifier B1 through capacitors C1 and C1', respectively. The DC- terminal of the rectifier B1 is connected to ground. The DC+ terminal of the rectifier B1 is connected to the DC- terminal of the rectifier B2. The AC+ terminal of the rectifier B1 is connected to the AC+ terminal of the rectifier B2 through capacitor C2. The AC- terminal of the rectifier B1 is connected to the AC- terminal of the rectifier B2 through capacitor C2', and so on, superimposed on the rectifier Bn.

5. The device as described in claim 2, characterized in that, The neural current regulation module further includes a monitoring circuit, the processor is connected to the monitoring circuit, and the monitoring circuit is connected to a voltage-controlled current source; the monitoring circuit includes a load, a second amplifier, a second digital-to-analog converter, and a second digital isolator; the load is connected to the second amplifier, the second amplifier is connected to the second digital-to-analog converter, and the second digital-to-analog converter is connected to the second digital isolator; The monitoring circuit is used to connect the output terminal of the voltage-controlled current source to the load to generate a voltage signal, which is then processed sequentially by the second amplifier, the second digital-to-analog converter, and the second digital isolator before being sent to the processor.

6. The device as described in claim 4, characterized in that, The EEG signal acquisition module includes a third amplifier, a third digital-to-analog converter, a third digital isolator, and a power isolation circuit; the power isolation circuit is connected to the third amplifier, the third digital-to-analog converter, and the third digital isolator respectively; the acquisition and control switching switch is connected to the third amplifier; the third amplifier is connected to the third digital-to-analog converter; the third digital-to-analog converter is connected to the third digital isolator; and the third digital isolator is connected to the processor.

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