Mental health evaluation method and system based on brain region electrical stimulation

Abstract

The invention discloses a mental health evaluation method and system based on brain region electrical stimulation, relates to the technical field of medical care informatics, creatively integrates brain region electrical stimulation into mental health evaluation, and objectively quantifies the basic cognitive level and neuroplasticity potential of a testee through comprehensive scores before and after brain region electrical stimulation. On the basis, a corresponding appropriate psychological health evaluation test question is selected, so that the accuracy and sensitivity of a corresponding psychological test and the psychological comfort of a testee are remarkably improved; an attenuation quantification model of stimulation current from the electrode to the brain is given, the power supply amount is accurately controlled according to the attenuation quantification model, and the maximization of the beneficial effect is realized under the condition of ensuring health and safety; historical data accumulated in the application process can be effectively used for solving the medical problems of influence of brain region electrical stimulation on child neurodevelopment evaluation, mental disease early warning, brain function enhancement and the like.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of healthcare informatics, in particular to a mental health evaluation method and system based on brain area electrical stimulation. BACKGROUND

[0002] The internationally recognized non-invasive brain stimulation technology is transcranial direct current stimulation technology. This technology continuously delivers low-intensity (≤2 mA) direct current to the cortex of a specific brain area, thereby changing the resting potential of the brain and promoting the cognitive ability of an individual. As a new, effective, simple and convenient non-invasive brain stimulation method, transcranial direct current stimulation technology has made remarkable research and development in improving the clinical symptoms of patients and enhancing the cognitive ability of healthy individuals.

[0003] Attention is a core element of individual cognitive ability and a prerequisite for performing higher cognitive functions. The efficiency, mode (such as bias, deviation, etc.) and stability of attention and cognitive ability deeply affect an individual's emotional experience, ability to cope with stress, and overall mental health level. The level of an individual's attention can be evaluated by the Shulte square test. The Shulte square is a square table with 5x5, a total of 25 small squares, filled with numbers 1 to 25 in random order. The subject needs to count from 1 to 25 as fast as possible and point out while reading, and the examiner records the time (or a computer program can be designed to record the time). The shorter the time, the stronger the attention of the subject.

[0004] By applying transcranial direct current stimulation technology to the Shulte square test, the brain potential of the subject can be evaluated by the time it takes for the subject to complete the Shulte square test before and after electrical stimulation. By combining the time it takes for the subject to complete the Shulte square test before electrical stimulation and the evaluation results of the subject's brain potential, a comprehensive score of the subject is obtained. By using the comprehensive score of the subject as a reference, suitable mental health evaluation questions are selected for the subject to test, which significantly improves the scientificity and accuracy of the test. SUMMARY

[0005] The purpose of the present application is to provide a mental health evaluation method and system that introduces dynamic Shulte square testing and transcranial direct current stimulation technology, based on comprehensive evaluation of the attention level and brain potential of the subject.

[0006] To solve the above technical problems, the technical solution adopted by the present application is as follows: a mental health evaluation method based on brain area electrical stimulation, comprising the following steps: Step Step 1: three rounds of dynamic Shulte square test are performed on the subject, and after the subject clicks a square in the Shulte square, the numbers in all the squares are randomly redistributed; the average time of the three rounds of dynamic Shulte square test is recorded as the reference time. Step Step 2: according to the gender, age, body fat rate, bone density and head diameter data of the subject in three directions, the current application scheme of the brain region electric stimulation of the subject is calculated and determined; Step Step 3: the discharge electrode for brain region electric stimulation is arranged in the head region corresponding to the dorsolateral prefrontal cortex of the subject, and according to the current application scheme of the subject, the brain region electric stimulation is continuously performed for 15-30 minutes; Step Step 4: after the brain region electric stimulation is completed, the subject is tested again for three rounds of dynamic Shulte square test, and the average time of the three rounds of dynamic Shulte square test is taken as the reference time; Step Step 5: according to the reference time and the reference time of the subject, the brain potential index of the subject is calculated; the mental health evaluation test is divided into high, medium and low three levels, the high level test has the largest number of questions, and the low level test has the smallest number of questions; according to the comprehensive score of the reference time and the brain potential index of the subject, the mental health evaluation test of the corresponding level is selected for answering test, and according to the answering test result, the mental health of the subject is evaluated, and the data and evaluation results of the whole test are archived.

[0007] Further, let the current directly acting on the brain of the subject at the moment t after the brain region electric stimulation starts be , t , the unit is second; in step Step 2, the current application scheme includes static application scheme, dynamic application scheme and pulse application scheme, when the current application scheme is static application scheme, there is , , wherein is a constant, the value range is [0, 2], the unit is mA; when the current application scheme is dynamic application scheme, there is , , wherein is the basic current, the value range is [0.5, 1], the unit is mA; H is the oscillation amplitude, the unit is mA; the basic current and the oscillation amplitude satisfy the relationship formula: ; is the oscillation frequency, the unit is Hz; is a phase shift angle, in radian; when the current application scheme is a pulse application scheme, has , wherein, is a pulse peak current, in mA, and the value range is [1.5, 2]; N is a burst number; P is a pulse interval period, in s; w is a pulse width, in s; is a carrier frequency, in Hz.

[0008] Further, the current released by the discharge electrode at the time of t after the brain area electrical stimulation starts is In step Step2, according to , the formula for calculating is , wherein, is an equivalent scalp conductivity, in s / m; is an equivalent skull conductivity, in s / m; is an equivalent scalp thickness, in mm; is an equivalent skull thickness, in mm; K is a compensation factor; G is a geometric factor, and the calculation formula of the geometric factor G is , wherein, Z is a head diameter factor, in cm -1 ; is a reference head diameter, in cm; is a longitudinal head diameter, and the longitudinal head diameter is the measurement distance from the forehead to the back of the head of the measured person, in cm; is a transverse head diameter, and the transverse head diameter is the measurement distance between the two temples of the measured person, in cm; is a vertical head diameter, and the vertical head diameter is the measurement distance from the top of the head to the junction of the occipital bone and the spine of the measured person, in cm.

[0009] Further, the calculation formula of the equivalent scalp conductivity is , wherein, is a reference scalp conductivity, in s / m; F is a body fat rate; b is a scalp attenuation factor.

[0010] Further, the calculation formula of the equivalent skull conductivity is , wherein, c is the reference skull conductivity, with the unit of s / m; d is the skull attenuation factor, with the unit of ; is the bone density, with the unit of .

[0011] Further, the calculation formula of the equivalent scalp thickness is , wherein, E is the reference scalp thickness, with the unit of mm; S is the gender coefficient, the value of S is 0 when the subject is female, and the value of S is 1 when the subject is male; A is the age value of the subject; is the first gender factor, with the unit of mm; is the first age factor, with the unit of mm; is the body fat factor, with the unit of mm.

[0012] Further, the calculation formula of the equivalent skull thickness is , wherein, J is the reference skull thickness, with the unit of mm; is the second gender factor, with the unit of mm; is the second age factor, with the unit of mm; is the bone density factor, with the unit of .

[0013] Further, assuming that the brain potential index of the subject is , the calculation formula of is , wherein, is the pre-reference time of the subject, with the unit of s; is the post-reference time of the subject, with the unit of s.

[0014] Further, assuming that the comprehensive score of the pre-reference time of the subject and the brain potential index is , the calculation formula of is , wherein, For time scoring, there are , For time scoring, there are , When The value is greater than 0, the high-grade test questions are selected for the testees to answer the test; when The value is equal to 0, the middle-grade test questions are selected for the testees to answer the test; when The value is less than 0, the low-grade test questions are selected for the testees to answer the test.

[0015] The application further provides a psychological health evaluation system based on brain area electric stimulation, adopts the psychological health evaluation method based on brain area electric stimulation, and comprises a computer, an electric stimulation device and an interactive module; the electric stimulation device and the interactive module are electrically connected with the computer; the electric stimulation device and the interactive module are in data interaction with the computer; an evaluation module and a storage module are arranged in the computer; the evaluation module is used for providing dynamic Cattell test and answering test; and the storage module is used for archiving and retaining data and evaluation results in the whole test process.

[0016] Compared with the prior art, the application has the following beneficial effects: (1) the application innovatively integrates brain area electric stimulation into psychological health evaluation, objectively quantifies the basic cognitive level and neural plasticity potential of the testees before and after brain area electric stimulation through comprehensive scores, and uses the same as a basis to select corresponding suitable psychological health evaluation test questions, thereby significantly improving the accuracy, sensitivity of corresponding psychological test and the psychological comfort of the testees; (2) the application provides a quantitative model of the attenuation of the stimulation current from the electrode to the brain, accurately controls the electric quantity according to the quantitative model of the attenuation, and maximizes the beneficial effects under the condition of health and safety; (3) the application not only provides a new psychological health evaluation method, but also effectively solves medical problems such as the influence of brain area electric stimulation on child neural development evaluation, early warning of mental illness and brain function strengthening through historical data accumulated in the process of using the method. BRIEF DESCRIPTION OF DRAWINGS

[0017] Figure 1 It is a schematic diagram of the principle of the steps of the psychological health evaluation method based on brain area electric stimulation.

[0018] Figure 2 It is a schematic diagram of the principle of the modules of the psychological health evaluation system based on brain area electric stimulation.

[0019] Figure 3 It is a schematic diagram of the layout area marking of the discharge electrode.

[0020] In the figure: 1-computer; 2-electric stimulation device; 3-interactive module; 4-evaluation module; 5-storage module. DETAILED DESCRIPTION

[0021] The technical solutions of the present application are further illustrated below in conjunction with the accompanying drawings and by specific embodiments, wherein the drawings are only used for illustrative purposes, represent only schematic diagrams, and cannot be understood as limitations to the present application; in order to better illustrate the embodiments of the present application, some components in the drawings are omitted, enlarged or reduced, and do not represent the actual product size; it is understandable for those skilled in the art that some well-known structures and their descriptions in the drawings can be omitted.

[0022] Figure 1 and Figure 2 Preferred embodiments of the present application are given.

[0023] As Figure 1 shown, the step principle of the mental health evaluation method based on brain area electrical stimulation is given, specifically: Step Step1: The measured person is subjected to three rounds of dynamic Shulte square test, and after the measured person clicks a square in the Shulte square, the numbers in all squares are randomly redistributed; after recording the time required by the measured person to complete each round of dynamic Shulte square test, the average time of the three rounds of dynamic Shulte square test is taken as the reference time; Step Step2: According to the gender, age, body fat rate, bone density and head diameter data in three directions of the measured person, the current application scheme of brain area electrical stimulation of the measured person is calculated and determined; the current directly acting on the brain of the measured person at the time after the brain area electrical stimulation starts is t , , t the unit is second; the current application scheme includes static application scheme, dynamic application scheme and pulse application scheme, when the current application scheme is the static application scheme, there is , in the formula, is a constant, the value range is [0, 2], the unit is mA; when the current application scheme is the dynamic application scheme, there is , in the formula, is the basic current, the value range is [0.5, 1], the unit is mA; H is the oscillation amplitude, the unit is mA; the basic current and the oscillation amplitude need to satisfy the relationship formula: ; is the oscillation frequency, the value range is [4, 50], the unit is Hz; is the phase shift angle, the unit is rad; when the current application scheme is the pulse application scheme, there is , in the formula, This represents the peak pulse current, with a value range of [1.5, 2], and the unit is mA. N The number of bursts, with a value range of [180, 900]; P The pulse interval period has a value range of [2,5] and is measured in seconds. w The pulse width is defined as [0.1, 0.3], and the unit is seconds (s). The carrier frequency has a value range of [100, 200] and is in Hz; in this embodiment, a static current application scheme is selected. The value is constant at 1.5 mA; assuming the electrical stimulation of the brain region begins after... t The current released by the discharge electrode at time is In step 2, according to calculate The formula is , In the formula, Equivalent scalp conductivity, in units of S / m; Equivalent skull conductivity, in units of S / m; Equivalent scalp thickness, in mm; Equivalent skull thickness, in mm; K As a compensation factor, its value ranges from [0.1, 0.5]. In this embodiment, K The value is 0.3; G Geometric factor G The calculation formula is , In the formula, Z This is the head diameter factor, with a value range of [0.01, 0.03]. In this embodiment, Z The value is 0.01, and the unit is cm. -1 ; The reference head diameter has a value range of [50, 60]. In this embodiment, The value is 55, and the unit is cm; The longitudinal head diameter is the distance from the forehead to the back of the head of the subject, measured in cm. The transverse head diameter is the distance between the two temples of the subject, measured in cm. The vertical head diameter is the distance measured from the top of the subject's head to the point where the occipital bone connects to the spine, and the unit is cm.

[0024] Specifically, equivalent scalp conductivity The calculation formula is , In the formula, The baseline scalp conductivity is used, with a value range of [0.28, 0.33]. In this embodiment, The value is 0.3, and the unit is s / m; F Body fat percentage; b The scalp attenuation factor has a value range of [0.01, 0.03]. In this embodiment, b The value is set to 0.02; equivalent skull conductivity. The calculation formula is , In the formula, c The baseline skull conductivity is used, with a value range of [0.008, 0.015]. In this embodiment, c The value is 0.01, and the unit is s / m; d The skull attenuation factor has a value range of [0.01, 0.03]. In this embodiment, d The value is 0.02, and the unit is... ; Bone mineral density, unit: Equivalent scalp thickness The calculation formula is , In the formula, E The baseline scalp thickness is [4.5, 5.5]. In this embodiment, E The value is 5, and the unit is mm; S This is the gender coefficient; when the subject is female, S When the value is 0, and the test subject is male, S The value is 1; A The age value of the test subject; The first gender factor has a value range of [0.4, 0.6]. In this embodiment, The value is 0.5, and the unit is mm; The first age factor has a value range of [0.01, 0.03]. In this embodiment, The value is 0.02, and the unit is mm; The body fat factor has a value range of [0.02, 0.05]. In this embodiment, The value is taken as 0.03, and the unit is mm; equivalent skull thickness. The calculation formula is , In the formula, J The baseline skull thickness is [6, 8]. In this embodiment, J The value is 7, and the unit is mm; The second gender factor has a value range of [0.5, 0.8]. In this embodiment, The value is 0.6, and the unit is mm; For the second age factor, the value range is [0.02, 0.05], in this embodiment, The value is 0.03, and the unit is mm; For the bone density factor, the value range is [1.8, 2.1], in this embodiment, The value is 2, and the unit is .

[0025] Step Step3: Place the discharge electrode for brain region electrical stimulation on the head region corresponding to the dorsolateral prefrontal cortex of the subject, and according to the current current application scheme of the subject, continuously perform brain region electrical stimulation for 15-30 minutes, in this embodiment, the duration of brain region electrical stimulation is set to 20 minutes; Step Step4: After the subject completes the brain region electrical stimulation, the subject is tested again for three rounds of dynamic Cylert Square test, and the average time of the time consumed in this three-round dynamic Cylert Square test is taken as the post-reference time; Step Step5: According to the pre-reference time and the post-reference time of the subject, the brain potential index of the subject is calculated, and the brain potential index of the subject is set to Then The calculation formula of , In the formula, The pre-reference time of the subject is s; The post-reference time of the subject is s; The psychological health evaluation test is divided into high, medium and low three levels, the high-level test has the largest number of questions, with 30 questions; The number of questions of the medium-level test is between the high-level and the low-level, with 20 questions; The number of questions of the low-level test is the smallest, with 10 questions; The pre-reference time and the comprehensive score of the brain potential index of the subject are set to Then The calculation formula of , In the formula, The time score is , The time score is , When the value of is greater than 0, the subject selects the high-level test for answering test; When the value of is equal to 0, the subject selects the medium-level test for answering test; When the value of is less than 0, the subject selects the low-level test for answering test; According to the answering test result, the psychological health of the subject is evaluated, and the data and evaluation results of the whole test are archived.

[0026] For example, Figure 2As shown, the psychological health evaluation system based on brain area electric stimulation provided by the present application is electrically connected with the computer 1, and the electric stimulation device 2 and the interactive module 3 are both in data interaction with the computer 1; the interactive module 3 includes a computer display, a mouse, a keyboard and an audio device; the computer 1 is provided with an evaluation module 4 and a storage module 5; the evaluation module 4 is used for providing dynamic Shulte square test and answering test; and the storage module 5 is used for archiving and retaining the data and evaluation results of the whole test.

[0027] The working principle of the present application: the electric stimulation device 2 of the present embodiment adopts the high-precision transcranial direct current stimulation device (model 1300A&4×1-C3A) of the American Soterix Medical Company, and the brain area of the measured person is selected as the left dorsolateral prefrontal cortex, such as Figure 3 As shown, F3 is selected as the anode discharge electrode site, and the cathode sites are AF3, F1, F5 and FC3. The electric stimulation device 2 is directly connected with the computer 1 with Windows system, the measured person sits in front of the computer 1 before the test, inputs and confirms his personal information, and then performs the work of step Step1; at the same time, the psychological test teacher starts to perform the work of step Step2, and determines the current application scheme, after the measured person completes the work of step Step1, the psychological teacher performs the work of step Step3 according to the decision result of step Step2, after the work of step Step3 is completed, the measured person repeats the work of step Step1 once, that is, the work of step Step4, after the work of step Step4 is completed, the computer 1 automatically calculates the comprehensive score, at the same time, the measured person is allowed to rest for a few minutes, then the test of step Step5 is completed, after the measured person completes the test, the psychological test teacher gives the evaluation result and operates the computer 1 to save the information data of the whole test.

Claims

1. A method for assessing mental health based on brain region electrical stimulation, characterized in that: Step 1: Conduct three rounds of dynamic Schulte grid test on the test subject. After the test subject clicks on a square in the Schulte grid, the numbers in all the squares will be randomly redistributed. Record the time required for the test subject to complete each round of dynamic Schulte grid test, and take the average time of the three rounds of dynamic Schulte grid test as the previous reference time. Step 2: Based on the subject's gender, age, body fat percentage, bone density, and head diameter data in three directions, calculate and determine the current application scheme for the subject's brain region electrical stimulation. Step 3: Place the discharge electrodes for brain region electrical stimulation in the head area corresponding to the dorsolateral prefrontal cortex of the subject, and perform brain region electrical stimulation for 15 to 30 minutes according to the current application plan of the subject. Step 4: After the subject completes the brain region electrical stimulation, the subject will undergo three rounds of dynamic Schulte grid test again, and the average time taken for these three rounds of dynamic Schulte grid test will be used as the subsequent reference time. Step 5: Calculate the subject's brain potential index based on the subject's pre-reference time and post-reference time; The mental health assessment test questions are divided into three levels: high, medium, and low. The high level test has the most questions, and the low level test has the fewest questions. Based on the comprehensive score of the test subject's pre-reference time and brain potential index, the corresponding level of mental health assessment test questions are selected for the test. The test results are used to evaluate the test subject's mental health status, and the data and evaluation results of the entire test process are archived and retained.

2. The mental health assessment method based on brain region electrical stimulation as described in claim 1, characterized in that: Assuming the brain region electrical stimulation begins after t The electrical current that directly affects the brain of the test subject at any given moment is , t The unit is seconds; In Step 2, the current application schemes include static application, dynamic application, and pulse application. When the current application scheme is a static application scheme, there are... ， In the formula, It is a constant with a value range of [0,2] and a unit of mA; when the current application scheme is a dynamic application scheme, we have ， In the formula, The base current has a range of [0.5, 1] ​​and is measured in mA. H The oscillation amplitude is expressed in mA; the base current and the oscillation amplitude must satisfy the following relationship: ; The oscillation frequency is expressed in Hz. This is the phase offset angle, in rad; when the current application scheme is a pulse application scheme, we have ， In the formula, This represents the peak pulse current, with a value range of [1.5, 2], and the unit is mA. N Number of outbreaks; P The pulse interval period is expressed in seconds (s). w The pulse width is expressed in seconds (s). The carrier frequency is expressed in Hz.

3. The mental health assessment method based on brain region electrical stimulation as described in claim 2, characterized in that: Assuming the brain region electrical stimulation begins after t The current released by the discharge electrode at time is In step 2, according to calculate The formula is ， In the formula, Equivalent scalp conductivity, in units of S / m; Equivalent skull conductivity, in units of S / m; Equivalent scalp thickness, in mm; Equivalent skull thickness, in mm; K As a compensation factor; G Geometric factor G The calculation formula is ， In the formula, Z This is the head diameter factor, in cm. -1 ; The reference head diameter is in cm. The longitudinal head diameter is the distance from the forehead to the back of the head of the subject, measured in cm. The transverse head diameter is the distance between the two temples of the subject, measured in cm. The vertical head diameter is the distance measured from the top of the subject's head to the point where the occipital bone connects to the spine, and the unit is cm.

4. The mental health assessment method based on brain region electrical stimulation as described in claim 3, characterized in that: Equivalent scalp conductivity The calculation formula is ， In the formula, The baseline scalp conductivity is expressed in s / m. F Body fat percentage; b It is a scalp attenuation factor.

5. A method for evaluating mental health based on brain region electrical stimulation as described in claim 4, characterized in that: Equivalent skull conductivity The calculation formula is ， In the formula, c The baseline skull conductivity is expressed in s / m. d This is the skull attenuation factor, in units of ; Bone mineral density, unit: .

6. The mental health assessment method based on brain region electrical stimulation as described in claim 5, characterized in that: Equivalent scalp thickness The calculation formula is ， In the formula, E The reference scalp thickness is in mm. S This is the gender coefficient; when the subject is female, S When the value is 0, and the test subject is male, S The value is 1; A The age value of the test subject; The first gender factor, in mm; The first age factor is expressed in mm. This refers to body fat factor, measured in mm.

7. A method for evaluating mental health based on brain region electrical stimulation as described in claim 6, characterized in that: Equivalent skull thickness The calculation formula is ， In the formula, J The baseline skull thickness is in mm. The second sex factor is expressed in mm. The second age factor is expressed in mm. Bone mineral density factor, unit: .

8. A method for evaluating mental health based on brain region electrical stimulation as described in claim 7, characterized in that: [The method is described in the original text, but the provided text is incomplete and cannot be translated accurately.] The brain potential index of the test subjects is ,but The calculation formula is ， In the formula, The previous reference time for the test subject is expressed in seconds. The post-reference time for the test subject is expressed in seconds.

9. A method for evaluating mental health based on brain region electrical stimulation as described in claim 8, characterized in that: Let the combined score of the test subject's pre-reference time and brain potential indicators be: ,but The calculation formula is ， In the formula, Rate the time, there are ， Rate the time, there are ， when When the value is greater than 0, advanced test questions are selected for the test subject to answer; when... When the value is 0, the test subject is given a medium-difficulty test question; when... When the value is less than 0, the test subject is given a lower difficulty level of questions to answer.

10. A mental health evaluation system based on brain region electrical stimulation, employing the mental health evaluation method based on brain region electrical stimulation as described in claim 9, comprising a computer (1), an electrical stimulation device (2), and an interactive module (3), characterized in that: Both the electrical stimulation device (2) and the interaction module (3) are electrically connected to the computer (1); both the electrical stimulation device (2) and the interaction module (3) interact with the computer (1) for data exchange; the computer (1) is equipped with an evaluation module (4) and a storage module (5); the evaluation module (4) is used to provide dynamic Schulte grid test and answer test; the storage module (5) is used to archive and retain the data and evaluation results of the entire test process.

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