106 results about "Neuro development" patented technology

The subject matter described herein includes methods, systems, and computer readable media for early detection of a neurodevelopmental or psychiatric disorder using scalable computational behavioral phenotyping. According to one method for early detection of a neurodevelopmental or psychiatric disorder using scalable computational behavioral phenotyping includes obtaining user related information, wherein the user related information includes metrics derived from a user interacting with one or more applications executing on at least one user device; generating, using the user related information and a machine learning based model, a user assessment report including a prediction value indicating a likelihood that the user has a neurodevelopmental or psychiatric (neurodevelopmental / psychiatric) disorder and a prediction confidence value computed using relative contributions of the metrics to the prediction value generated using the machine learning based model; and providing the user assessment report to a display or a data store.

The invention discloses a nutritional composition for promoting neurodevelopment and application, and provides a nutritional composition for promoting neurodevelopment, which comprises the following necessary components: a sialylated substance component comprising one or more of N-acetylneuraminic acid, sialylated oligosaccharide, sialylated protein and sialylated lipid; the whey protein component comprises alpha-lactalbumin; and a peptide component from casein, including a hydrolysate of casein; the nutritional composition comprises a sialylated substance component, a whey protein component and a casein-derived peptide component, and the mass ratio of the sialylated substance component, the whey protein component and the casein-derived peptide component in the nutritional composition is (0.5-10): (300-1): (100-0.5). The nutritional composition provided by the invention can promote brain development and cognitive functions, and can significantly promote neurodevelopment by scientifically matching the sialylated substance component, the whey protein component and the peptide component from casein.

The invention provides a neural developmental disorder prediction model construction method, system and device and a medium, and the method comprises the steps: obtaining the clinical information of a child patient, the clinical information comprises severity of developmental retardation / dyspepsia, complexity of syndromic neurodevelopmental disorder, autism spectrum disorder, epilepsy, attention deficit hyperactivity disorder, head circumference deformity, brain development deformity, hearing / visual function impairment and related ear-eye development deformity; applying logistic regression analysis to screen out predictive factors significantly related to the positive diagnosis rate of third-generation whole exon genome sequencing in the clinical information; constructing a neural developmental disorder prediction model based on binary logistic regression according to the prediction factor; and verifying the neurodevelopmental disorder prediction model by applying data of the internal verification group and the external verification group so as to evaluate the prediction efficiency of the neurodevelopmental disorder prediction model, so that the probability of obtaining positive diagnosis after the child patient receives trio-WES detection can be accurately evaluated, and the prediction efficiency is remarkably improved.

The application discloses a mental health evaluation method and system based on brain area electric stimulation, relates to the technical field of medical and health information science, and creatively integrates brain area electric stimulation into mental health evaluation. The basic cognitive level and neural plasticity potential of a measured person are objectively quantified through comprehensive scores before and after brain area electric stimulation, so that corresponding suitable mental health evaluation test questions are selected based on the basic cognitive level and neural plasticity potential, and the precision, sensitivity of corresponding mental tests and the mental comfort of the measured person are significantly improved. A decay quantization model of a stimulating current from an electrode to the brain is given, the decay quantization model is used to accurately control the electric quantity, and the maximum beneficial effect is realized under the condition of guaranteeing health and safety. Historical data accumulated in the application process can be effectively used to solve medical problems, such as the influence of brain area electric stimulation on child neural development evaluation, early warning of mental illness and brain function reinforcement.

The invention belongs to the technical field of microbial engineering, discloses a composition for promoting infant brain development and application thereof, and provides a composition containing lactobacillus paracasei N1115, breast milk oligosaccharide and whey protein powder, the composition can promote infant brain and nerve development, all the components have a synergistic effect, and the effect of promoting infant brain and nerve development is achieved. The conversion from latent TGF-beta in the whey protein powder to activated TGF-beta is activated, so that the aims of promoting neurodevelopment, improving memory and promoting brain development of infants are fulfilled. The preparation method is suitable for preparing milk powder, cheese, yoghourt, plant-based yoghourt and derivative products or other foods for promoting brain development of infants.

The invention discloses a nutritional composition for promoting central nervous system development and application. The invention provides a nutritional composition for promoting the development of a central nervous system. The nutritional composition comprises the following necessary components: a breast milk oligosaccharide component and a casein phosphopeptide component, moreover, in the composition, the mass ratio of the breast milk oligosaccharide component to the casein phosphopeptide component is (1-100): (500-1). According to the invention, the breast milk oligosaccharide component and the casein phosphopeptides are matched to prepare the nutritional composition, and the nutritional composition can significantly promote nerve development such as neuronal maturation, synaptic generation and myelin sheath formation.

The invention discloses a neural development disorder co-disease identification system based on a residual image neural network. Belongs to the technical field of neurodevelopment disorder co-disease recognition, and particularly relates to the technical field of co-disease recognition based on a neural network. The system comprises a data acquisition module for acquiring a resting-state fMRI image; the data preprocessing module is used for extracting standardized time sequences of 116 brain regions of the set resting state fMRI image; the multi-band division and feature extraction module is used for performing frequency band filtering on the standardized time sequence of each brain region to obtain a time sequence after each frequency band filtering; in each frequency band, constructing a binary topological matrix based on the PLV matrix and calculating a PLV feature vector based on the PLV matrix; the neurodevelopmental disorder co-disease recognition module is used for analyzing the brain function connection diagram through a residual image neural network model to obtain diagnostic information of neurodevelopmental disorder co-diseases; and the interpretable output module is used for outputting an abnormal brain region by taking the amplitude low-frequency fluctuation as a reference index.

The invention belongs to the technical field of nutritional compositions, and particularly relates to a composition, a preparation method thereof and application of the composition in protecting brain health. The composition provided by the invention is prepared from docosahexaenoic acid, 3-sialic acid lactose and phosphatidylserine. The composition is clear in sleep improvement effect, can effectively solve the problem of sleep maintenance caused by sleep deprivation, has the effects of protecting neural functions, improving memory and relieving anxiety from multiple dimensions, and can repair brain tissue damage and protect brain health. Based on the composition, products for assisting in improving memory, preventing and treating insomnia and anxiety, regulating neurodevelopmental disorders, protecting brain health and improving concentration can be developed, the health requirements of different people are comprehensively met, and the application value is high.

Provided are platforms, methods, and systems to customize virtual or augmented reality (collectively, XR) content for an individual or a group of individuals, such as to treat a user having a mental or neurodevelopmental disorder (e.g., autism), train or educate an individual (e.g., student) or a group of individuals, or otherwise attend to a special need of an individual or a group of individuals. A graphical user interface may be used to edit the XR content.

The invention disclosed herein relates to metal-catalyst free, green enantioselective synthesis of sulfoxide compounds of Formula-I. Particularly, the present invention relates to in situ process to obtain enantioselective sulfoxide compounds of Formula-I with high yield and purity and specific optical rotation. Further, the enantioselective sulfoxide compounds of Formula-I are useful in the treatment of neurological, neuropsychiatric, metabolic and neurodevelopmental disorder.

The invention discloses a nutritional composition for promoting neurodevelopment. The invention provides a nutritional composition, the nutritional composition comprises the following necessary components: a grease component, a phospholipid component and a sialylated substance component, and in the nutritional composition, the molar ratio of the grease component to the phospholipid component to the sialylated substance component is (1-5): (1-10): (0.01-5). The composition provided by the invention has the advantages that the components are synergistic, the nerve development is effectively promoted, the application range is wide, and various foods or health-care products can be conveniently added or prepared.

To provide an execution function evaluation device capable of evaluating an execution function related to a symptom of a neurodevelopmental disease group.SOLUTION: An execution function evaluation device 1 is an evaluation device for an execution function related to a symptom of a neurodevelopmental disease group, and includes: a memory 12 for storing operation information showing an operation by an evaluation object person A, the operation being for a virtual space in which a task is set, displayed in a user terminal 3; and an arithmetic part 11 for evaluating an execution function of the evaluation object person. An index of the execution function of the evaluation object person is calculated using relationships among a plurality of virtual spaces of the operation information by the evaluation object person in each of the plurality of virtual spaces with different set tasks, displayed in the user terminal.SELECTED DRAWING: Figure 1

The invention discloses a composition for treating dysgnosia, application thereof and a medicine screening method. According to the invention, the AAV virus carrying the hCAPZA2 gene is introduced into a CAPZA2 heterozygous knockout or mutated mouse model, and the effectiveness of the AAV virus in the aspects of improving the CAPZA2 expression level, recovering the synaptic function and improving the neural behavior is verified. The invention not only provides a new hope for treating the mental disorder related to the CAPZA2 gene, but also opens up a new direction for the application of gene therapy in neurodevelopment diseases.

Provided are oligomeric agents, oligomeric compounds, methods, and pharmaceutical compositions for reducing the amount or activity of Protocadherin 19 (PCDH19) RNA in a cell or subject, and in certain instances reducing the amount of PCDH19 protein in a cell or subject. Such oligomeric agents, oligomeric compounds, methods, and pharmaceutical compositions are useful to ameliorate at least one symptom or hallmark of a neurodevelopmental disease or disorder. Such neurodevelopmental diseases or disorders include PCDH19 Epilepsy. Such symptoms or hallmarks include seizures, cognitive impairment, intellectual disabilities, autism spectrum disorder, behavioral problems, aggression, anxiety, obsessive-compulsive disorder, hyperactivity, attention deficit disorder (ADD), and attention deficit hyperactivity disorder (ADHD).

The application provides a child neuropsychological development monitoring and management system. The system uses brain physiological parameters, brain MRI images, development scale characteristics and corresponding child neuropsychological development suffering grades to construct a child neuropsychological development evaluation model. The constructed child neuropsychological development evaluation model generates a current child neuropsychological development suffering grade of a user according to real-time brain physiological parameters collected by a system terminal, real-time brain MRI images monitored by a hospital and corresponding real-time development scale characteristics, provides a basis for whether the corresponding child needs further monitoring according to the current child neuropsychological development suffering grade, and improves the probability of finding potential abnormal development children. The application uses three kinds of fusion parameters related to child brain nerves, such as brain physiological parameters, brain image characteristics and subjective measurement table characteristics, to construct a high-precision real-time processing model, realizes intelligent monitoring of the morbidity of child neuropsychological development disorders by doctors, and reduces the burden on families.

The invention relates to the field of neurodevelopmental disorders, and discloses an electro-oculogram signal analysis and diagnosis system based on neurodevelopmental disorders, which extracts signal features from pre-processed electro-oculogram signals, and analyzes inter-group differences between signal features of a child patient group and signal features of a healthy child group. The method comprises the following steps: preliminarily screening out signal features with significant statistical difference between two groups, then carrying out severity correlation analysis on the screened signal features, screening and forming a feature list highly related to ADHD severity, and then comparing eye movement features of a child patient group under natural behaviors with eye movement features of a healthy child group, so as to obtain a feature list related to ADHD severity. The method comprises the following steps of: identifying and forming an abnormal signal feature list, fusing the feature list highly related to the ADHD severity and the abnormal signal feature list, calculating a comprehensive abnormal score, drawing an ROC curve according to the calculated comprehensive abnormal score, and carrying out grading evaluation on the ADHD severity of a child patient, so that accurate diagnosis and severity judgment on the ADHD disease are realized.

The present invention relates to a composition for treating or preventing neurodevelopmental disorders, particularly autism spectrum disorder, by selectively activating brain-resident regulatory T cells (Tregs). The present composition comprises IL-2 or an IL-2 gene (AAV-GFAP-IL-2) as an active ingredient, and induces Treg proliferation in the brain to alleviate neuroinflammation and improve behavioral defects.

The invention relates to the field of child neural development training, and discloses a child neural development collaborative four-dimensional dynamic training method and system, and the system comprises hardware such as a central processing unit, a multi-modal evaluation input end and an electroencephalogram signal collection device, and software modules such as a mapping analysis module and a scheme generation module. The method comprises the following steps: acquiring initial data such as age and traditional Chinese medicine syndrome characteristics of a trained object, modeling based on a four-dimensional state space vector, determining a target intervention brain region by utilizing a five-element viscera-brain region attribute mapping matrix, and constructing a training execution vector in combination with an age division control strategy; through closed-loop monitoring of electroencephalogram signals and action data, nerve relaxation and concentration indexes and action execution precision are calculated, and training parameters are dynamically adjusted through a PID (Proportion Integration Differentiation) algorithm; a multi-dimensional safety fusing mechanism is fused, and a comprehensive development index is generated and recorded after training. According to the method, traditional Chinese and western medicine theories are fused, age-based precise adaptation and nerve and movement coordinated regulation are achieved, the training pertinence and safety are improved, and the method is suitable for nerve development intervention of 12-36-month-old children.

The presently disclosed subject matter relates to a play environment for children and infants for detecting motor delays or impairments, evaluating neurological development, and for diagnosing developmental disorders, and methods and systems of using the same.

The presently disclosed subject matter relates to a play environment for children and infants for detecting motor delays or impairments, evaluating neurological development, and for diagnosing developmental disorders, and methods and systems of using the same.

The invention discloses a premature infant apnea early-warning intervention device and method, and relates to the technical field of medical equipment, and the premature infant apnea early-warning intervention device comprises an apnea monitor and a warm-keeping box. Through the arrangement of the plurality of stimulation soft rods, the plurality of insertion rods, the plurality of hollow rods, a main pipe, a driving shaft, a driving motor, a communicating pipe, a third piston column and a pipe sleeve, the extending length of the insertion rods is adaptively adjusted according to the weight of a premature infant, so that the collision force of the stimulation soft rods to the back of the premature infant is changed according to the weight of the premature infant; for the premature infant with light weight, the tactile nerve development is not mature enough, tactile stimulation slightly larger than that of the premature infant with heavy weight is needed, the retraction distance of the corresponding inserting rod is synchronously increased along with the increase of the weight of the premature infant, and under the condition that the driving motor drives the driving shaft to keep the rotating speed unchanged, the premature infant can be driven to rotate. Correspondingly, the conflict frequency of the stimulation soft rod is slightly increased, and discomfort of the premature infant caused by too large adjustment amplitude is avoided.

The invention relates to the technical field of functional foods, and particularly discloses a dietary therapy composition for promoting repair of cranial nerve damaged cells and a preparation method. The composition is prepared from the following raw materials in parts by weight: artichoke peptide, taurine, phosphatidylserine, natural nicotinic acid, guarana extract, collagen peptide, acerola cherry fruit powder, inulin, yak bone marrow powder, vitamin B family, sialic acid and sucralose. The preparation method comprises the following steps: S1, pretreating the raw materials; s2, performing nano crushing; s3, low-temperature drying; s4, embedding the inulin; and S5, mixing and forming. The artichoke peptide and the phosphatidylserine are synergistically matched, and a compound component with liver and brain axis functions is taken into consideration, so that a multi-target synergistic effect is achieved, the requirements of cell repair and neural development are synchronously met, and compared with single-component supplement or neglect of the influence of liver detoxification on brain repair in the prior art, the brain repair effect is greatly improved. The problems of low repairing efficiency and insufficient component utilization rate are solved.

The invention provides a USVs-based juvenile mouse model sensory perception quantitative evaluation method and application, the evaluation method can evaluate the sensory perception ability of a juvenile mouse model, a juvenile mouse can give out ultrasonic waves in the maternal and infant separation period, cold stimulation lower than a comfortable temperature is performed on the juvenile mouse in the maternal and infant separation period, and the sensory perception ability of the juvenile mouse model can be evaluated. Different sound production expressions caused by cold stimulation are analyzed, and the perceptual ability is evaluated. Based on the evaluation method, firstly, the perceptual ability of the juvenile autism mouse model can be effectively evaluated in the early stage of the disease; secondly, abnormal perception of a neurodevelopment disorder patient taking autism as an example on pain can be effectively simulated; the experiment device is easy to obtain, and the damage to the mouse is small.

The invention discloses a method for constructing a social anomaly mouse model, relates to the technical field of animal model construction, and constructs a social anomaly model of a filial generation mouse by performing bisphenol S exposure on a female mouse in a pregnancy and nursing period. According to the mouse model constructed by the invention, in the pregnancy and nursing period, BPS is exposed, and the development of left secondary motor cortex neurons is damaged, so that progeny is induced to have social behavior disorder; the activity of neurons in the left M2 brain region is activated, so that social behavior disorders can be effectively relieved. The invention not only clarifies the neural development mechanism of the environmental endocrine disrupter-induced autism-like social disorder, but also provides a new thought of activating left M2 neurons as a potential intervention means, and can be used for developing drugs for treating the social behavior disorder induced by the environmental endocrine disrupter; the invention provides a new direction for etiological research and treatment strategy exploration of neurodevelopment disorder diseases taking social defects as core symptoms, and is beneficial to promoting deep development of related medical research.

The invention relates to the technical field of health information analysis, in particular to a neuropediatric clinical potential safety hazard analysis method and system.The method comprises the steps that based on real-time monitoring of patient data, neural development monitoring indexes including reflection intensity and sensory response are captured, neural development characteristics of a patient are analyzed in combination with medical records, and a neural development characteristic analysis result is obtained; and analyzing the abnormality of the neural behavior according to the neural development feature analysis result to obtain an abnormal neural behavior recognition result. According to the method, through real-time monitoring and original medical record data analysis, neural development characteristics are deeply analyzed, abnormal behaviors are accurately recognized, information integration is optimized, the sensitivity and diagnosis speed of neuropathy are improved, risk level and disease risk factor analysis is introduced, individuation of prevention measures is enhanced, the pertinence and success rate of a treatment scheme are improved, and the method is suitable for popularization and application. A real-time feedback mechanism ensures the optimization of treatment measures, and the treatment safety and effect are remarkably improved.

The present technology relates to sensory apparatuses that are useful for individuals who need assistance with neurodevelopmental conditions such as autism spectrum disorder (ASD), sensory processing disorder (SPD), attention deficit disorder (ADD) and attention deficit hyperactivity disorder (ADHD). Such apparatuses can include a top cover connected to or integral with a top base plate, and a bottom cover connected to or integral with a bottom base plate, about which projections or wings having different visual or tactile properties, such as different textures, are rotatably attached. The present technology is also directed to systems and methods for the management of a neurodevelopmental condition.

The invention discloses a dietary therapy formula for repairing damaged cells and promoting cranial nerve development and a preparation method, and the dietary therapy formula comprises the following components in parts by weight: 1-2 parts of bone collagen peptide, 1-2 parts of taurine, 1-2 parts of bovine bone marrow powder, 2-4 parts of inulin, 2-4 parts of acerola cherry fruit powder, 3-4 parts of guarana extract and 4-6 parts of N-acetylneuraminic acid. 4-5 parts of vitamin B6, 2-4 parts of vitamin B1 and 2-4 parts of vitamin B2; the traditional Chinese medicine composition is capable of repairing damaged cells and promoting cranial nerve development, and has remarkable effects of inhibiting the onset of neurological diseases, promoting the repair of nerve cells and promoting nerve development.

The present invention generally relates to methods and systems for predicting one or more a kinetic biomarkers associated with one or more neurodevelopmental disorder, such as autism spectrum disorder, by monitoring and analysing various movement behaviours. Specifically, the present invention can be applied to monitor and record data on atypical movement behaviours, such as tiptoe behaviour and axis-spinning, when observed in subjects including children and adults. An aspect of the invention relates to a computer-implemented method for predicting a kinetic biomarker associated with a neurodevelopmental disorder; the method comprising: - receiving a first data flow indicative of a movement and orientation of the lower leg of the subject; - receiving a second data flow indicative of a movement and orientation of the foot of the subject; - determining using at least one machine learning model that the first data flow and second data flow correspond to an atypical movement event; - determining, based on a frequency of occurrence of the atypical movement event during a predetermined time window, that the first data flow and the second data flow correspond to at least one kinetic biomarker associated with the neurodevelopmental disorder; and, - generating a report comprising the kinetic biomarker.

This invention provides the application of a nutritional composition in the preparation of products that promote neural development and support the improvement of neural function. The research of this invention found that intervention in the body using a nutritional composition comprising *Bifidobacterium animalis* subsp. *lactobacterium* CP-9 and 3'-sialic acid lactose can promote the development of amygdala neuronal structure, improve neural plasticity, and enhance synaptic function, thereby promoting the formation and functional maturation of the normal amygdala structure. As a core brain region regulating emotional responses, social cognition, and stress responses, the normal development of the amygdala plays a crucial role in an individual's emotional regulation ability, social interaction behavior, cognitive function, and mental health. Therefore, this invention promotes the structural and functional development of the amygdala through nutritional intervention, ultimately improving an individual's emotional regulation ability, social interaction behavior, cognitive function, and mental health.

Provided are apparatuses, a non-transitory computer-readable medium or media, for enhancing prediction of neurodevelopmental disorder using a fundus image of a subject. In certain aspects, disclosed a method including the steps of: receiving the fundus image; segmenting a region of interest for the fundus image based on a machine learning model; mapping an adversarial noise to the region of interest; processing the fundus image to classify one or more features contained in the region of interest, which is mapped by the adversarial noise, using the machine learning model; and predicting, based on a classification, whether the fundus image is indicative of presence of neurodevelopmental disorder in the subject.