51 results about "Neuro development" patented technology

The invention discloses a nutritional composition for promoting neurodevelopment and application, and provides a nutritional composition for promoting neurodevelopment, which comprises the following necessary components: a sialylated substance component comprising one or more of N-acetylneuraminic acid, sialylated oligosaccharide, sialylated protein and sialylated lipid; the whey protein component comprises alpha-lactalbumin; and a peptide component from casein, including a hydrolysate of casein; the nutritional composition comprises a sialylated substance component, a whey protein component and a casein-derived peptide component, and the mass ratio of the sialylated substance component, the whey protein component and the casein-derived peptide component in the nutritional composition is (0.5-10): (300-1): (100-0.5). The nutritional composition provided by the invention can promote brain development and cognitive functions, and can significantly promote neurodevelopment by scientifically matching the sialylated substance component, the whey protein component and the peptide component from casein.

The invention discloses a nutritional composition for promoting central nervous system development and application. The invention provides a nutritional composition for promoting the development of a central nervous system. The nutritional composition comprises the following necessary components: a breast milk oligosaccharide component and a casein phosphopeptide component, moreover, in the composition, the mass ratio of the breast milk oligosaccharide component to the casein phosphopeptide component is (1-100): (500-1). According to the invention, the breast milk oligosaccharide component and the casein phosphopeptides are matched to prepare the nutritional composition, and the nutritional composition can significantly promote nerve development such as neuronal maturation, synaptic generation and myelin sheath formation.

The invention discloses a nutritional composition for promoting neurodevelopment. The invention provides a nutritional composition, the nutritional composition comprises the following necessary components: a grease component, a phospholipid component and a sialylated substance component, and in the nutritional composition, the molar ratio of the grease component to the phospholipid component to the sialylated substance component is (1-5): (1-10): (0.01-5). The composition provided by the invention has the advantages that the components are synergistic, the nerve development is effectively promoted, the application range is wide, and various foods or health-care products can be conveniently added or prepared.

The invention relates to the field of neurodevelopmental disorders, and discloses an electro-oculogram signal analysis and diagnosis system based on neurodevelopmental disorders, which extracts signal features from pre-processed electro-oculogram signals, and analyzes inter-group differences between signal features of a child patient group and signal features of a healthy child group. The method comprises the following steps: preliminarily screening out signal features with significant statistical difference between two groups, then carrying out severity correlation analysis on the screened signal features, screening and forming a feature list highly related to ADHD severity, and then comparing eye movement features of a child patient group under natural behaviors with eye movement features of a healthy child group, so as to obtain a feature list related to ADHD severity. The method comprises the following steps of: identifying and forming an abnormal signal feature list, fusing the feature list highly related to the ADHD severity and the abnormal signal feature list, calculating a comprehensive abnormal score, drawing an ROC curve according to the calculated comprehensive abnormal score, and carrying out grading evaluation on the ADHD severity of a child patient, so that accurate diagnosis and severity judgment on the ADHD disease are realized.

The present invention relates to a composition for treating or preventing neurodevelopmental disorders, particularly autism spectrum disorder, by selectively activating brain-resident regulatory T cells (Tregs). The present composition comprises IL-2 or an IL-2 gene (AAV-GFAP-IL-2) as an active ingredient, and induces Treg proliferation in the brain to alleviate neuroinflammation and improve behavioral defects.

The invention relates to the field of child neural development training, and discloses a child neural development collaborative four-dimensional dynamic training method and system, and the system comprises hardware such as a central processing unit, a multi-modal evaluation input end and an electroencephalogram signal collection device, and software modules such as a mapping analysis module and a scheme generation module. The method comprises the following steps: acquiring initial data such as age and traditional Chinese medicine syndrome characteristics of a trained object, modeling based on a four-dimensional state space vector, determining a target intervention brain region by utilizing a five-element viscera-brain region attribute mapping matrix, and constructing a training execution vector in combination with an age division control strategy; through closed-loop monitoring of electroencephalogram signals and action data, nerve relaxation and concentration indexes and action execution precision are calculated, and training parameters are dynamically adjusted through a PID (Proportion Integration Differentiation) algorithm; a multi-dimensional safety fusing mechanism is fused, and a comprehensive development index is generated and recorded after training. According to the method, traditional Chinese and western medicine theories are fused, age-based precise adaptation and nerve and movement coordinated regulation are achieved, the training pertinence and safety are improved, and the method is suitable for nerve development intervention of 12-36-month-old children.

The presently disclosed subject matter relates to a play environment for children and infants for detecting motor delays or impairments, evaluating neurological development, and for diagnosing developmental disorders, and methods and systems of using the same.

The presently disclosed subject matter relates to a play environment for children and infants for detecting motor delays or impairments, evaluating neurological development, and for diagnosing developmental disorders, and methods and systems of using the same.

The invention relates to the technical field of functional foods, and particularly discloses a dietary therapy composition for promoting repair of cranial nerve damaged cells and a preparation method. The composition is prepared from the following raw materials in parts by weight: artichoke peptide, taurine, phosphatidylserine, natural nicotinic acid, guarana extract, collagen peptide, acerola cherry fruit powder, inulin, yak bone marrow powder, vitamin B family, sialic acid and sucralose. The preparation method comprises the following steps: S1, pretreating the raw materials; s2, performing nano crushing; s3, low-temperature drying; s4, embedding the inulin; and S5, mixing and forming. The artichoke peptide and the phosphatidylserine are synergistically matched, and a compound component with liver and brain axis functions is taken into consideration, so that a multi-target synergistic effect is achieved, the requirements of cell repair and neural development are synchronously met, and compared with single-component supplement or neglect of the influence of liver detoxification on brain repair in the prior art, the brain repair effect is greatly improved. The problems of low repairing efficiency and insufficient component utilization rate are solved.

The invention discloses a method for constructing a social anomaly mouse model, relates to the technical field of animal model construction, and constructs a social anomaly model of a filial generation mouse by performing bisphenol S exposure on a female mouse in a pregnancy and nursing period. According to the mouse model constructed by the invention, in the pregnancy and nursing period, BPS is exposed, and the development of left secondary motor cortex neurons is damaged, so that progeny is induced to have social behavior disorder; the activity of neurons in the left M2 brain region is activated, so that social behavior disorders can be effectively relieved. The invention not only clarifies the neural development mechanism of the environmental endocrine disrupter-induced autism-like social disorder, but also provides a new thought of activating left M2 neurons as a potential intervention means, and can be used for developing drugs for treating the social behavior disorder induced by the environmental endocrine disrupter; the invention provides a new direction for etiological research and treatment strategy exploration of neurodevelopment disorder diseases taking social defects as core symptoms, and is beneficial to promoting deep development of related medical research.

The present technology relates to sensory apparatuses that are useful for individuals who need assistance with neurodevelopmental conditions such as autism spectrum disorder (ASD), sensory processing disorder (SPD), attention deficit disorder (ADD) and attention deficit hyperactivity disorder (ADHD). Such apparatuses can include a top cover connected to or integral with a top base plate, and a bottom cover connected to or integral with a bottom base plate, about which projections or wings having different visual or tactile properties, such as different textures, are rotatably attached. The present technology is also directed to systems and methods for the management of a neurodevelopmental condition.

The invention discloses a dietary therapy formula for repairing damaged cells and promoting cranial nerve development and a preparation method, and the dietary therapy formula comprises the following components in parts by weight: 1-2 parts of bone collagen peptide, 1-2 parts of taurine, 1-2 parts of bovine bone marrow powder, 2-4 parts of inulin, 2-4 parts of acerola cherry fruit powder, 3-4 parts of guarana extract and 4-6 parts of N-acetylneuraminic acid. 4-5 parts of vitamin B6, 2-4 parts of vitamin B1 and 2-4 parts of vitamin B2; the traditional Chinese medicine composition is capable of repairing damaged cells and promoting cranial nerve development, and has remarkable effects of inhibiting the onset of neurological diseases, promoting the repair of nerve cells and promoting nerve development.

This invention provides the application of a nutritional composition in the preparation of products that promote neural development and support the improvement of neural function. The research of this invention found that intervention in the body using a nutritional composition comprising *Bifidobacterium animalis* subsp. *lactobacterium* CP-9 and 3'-sialic acid lactose can promote the development of amygdala neuronal structure, improve neural plasticity, and enhance synaptic function, thereby promoting the formation and functional maturation of the normal amygdala structure. As a core brain region regulating emotional responses, social cognition, and stress responses, the normal development of the amygdala plays a crucial role in an individual's emotional regulation ability, social interaction behavior, cognitive function, and mental health. Therefore, this invention promotes the structural and functional development of the amygdala through nutritional intervention, ultimately improving an individual's emotional regulation ability, social interaction behavior, cognitive function, and mental health.

The application discloses application of a TPP2 mutant zebrafish in an ASD neurodevelopment-related disease model and belongs to the technical field of biological medicines. It is found for the first time that a TPP2 gene deletion type zebrafish has the following phenotypes: developmental retardation, developmental deformity, abnormal motor function, social dysfunction, stereotyped behavior, anxiety-like behavior and the like, has the core characteristics of ASD-related neurodevelopment-related diseases and can be used as an animal model for researching ASD neurodevelopment-related diseases, thereby providing an effective approach for diagnosing or treating ASD neurodevelopment-related diseases.

The invention discloses a dietary therapy formula for repairing damaged cells and promoting cranial nerve development and a preparation method, and the dietary therapy formula comprises the following components in parts by weight: 1-2 parts of bone collagen peptide, 1-2 parts of taurine, 1-2 parts of bovine bone marrow powder, 2-4 parts of inulin, 2-4 parts of acerola cherry fruit powder, 3-4 parts of guarana extract and 4-6 parts of N-acetylneuraminic acid. 4-5 parts of vitamin B6, 2-4 parts of vitamin B1 and 2-4 parts of vitamin B2; the traditional Chinese medicine composition is capable of repairing damaged cells and promoting cranial nerve development, and has remarkable effects of inhibiting the onset of neurological diseases, promoting the repair of nerve cells and promoting nerve development.

An infant developmental platform includes a bassinet configured to support an infant, a plurality of sensors integrated into the bassinet and a processor operatively connected to the plurality of sensors configured to receive sensor data from the plurality of sensors and utilize the sensor data in analyzing neurodevelopmental milestones to generate real-time infant care strategies and developmental insights for neurodevelopment of the infant. The platform may include a graphical user interface operatively connected to the processor, wherein the graphical user interface is configured to display the real-time infant care strategies and developmental insights and receive caregiver feedback data. The platform may include a feedback module operatively connected to the processor and configured to adjust processor inference models based on the caregiver feedback data received via the graphical user interface or on changes in sensor data corresponding to infant physiological or behavioral patterns indicative of neurodevelopmental milestones.

The present disclosure relates to nerve growth factor (NGF) for use in the prevention or treatment of neurodevelopmental disabilities associated with neonatal hypoxic-ischemic encephalopathy in a subject, wherein the NGF is administered intranasally to the subject.

The application belongs to the technical field of regenerative medicine, and discloses a kind of organoid culture method derived from human and non-human primate subventricular zone neural stem cells. By optimizing the medium formula and regulating transcription factors, the organoid is successfully induced to differentiate into CRABP1-expressing neuronal precursors. These cells express TAC3, and the application overcomes the limitations of existing technologies in simulating primate-specific neural lineages and complex brain structures, providing a breakthrough in vitro model for studying neural development, neurological diseases and drug development. The established system not only provides a new tool for studying the development of primate nervous system and disease mechanism, but also provides a reliable experimental platform and transplantable cell source for developing targeted drugs, constructing advanced disease models and conducting cell replacement therapy.

This invention provides a neurodevelopmental drug screening system and its applications based on a set of microglia markers. Specifically, this invention provides a neurodevelopmental supportive microglia subset that expresses markers of neurogenesis and development, as well as energy metabolism. This invention also provides a neurodevelopmental drug screening system and method using changes in the state of this cell subset as the core evaluation indicator. The system of this invention can sensitively and quantitatively reflect the regulatory effect of candidate drugs on the pro-neural maturation function of microglia in developmental brain injury, filling the technical gap in existing drug screening systems that lack "developmental immune-metabolic-synaptic linkage indicators."

One variation of a method for modeling neurological development includes: aggregating electroencephalography (EEG) data that comprise multiple EEG signals of each user in a set of users, EEG signals of each user recorded on multiple distinct dates, the set of users comprising a plurality of users of various known neurological statuses; identifying a synchronization pattern trend within the EEG data of the set of users; and correlating the synchronization pattern trend with neurological development within the set of users.

The invention discloses a medicine for treating neurodevelopment disorder diseases. The invention provides a etiological treatment method capable of crossing a blood brain barrier and directly targeting neural synaptic function repair, stable expression of an exogenous TBL1XR1 gene in a plurality of key brain regions (including hippocampus, prefrontal lobe, basal ganglion and the like) can be realized, and the TBL1XR1 gene has good brain targeting property and tissue affinity, and can be applied to the field of brain diagnosis and treatment. The synaptic disorder in the nervous system and the related nerve development process can be improved, and the composition has good safety in the aspects of system and nerve immunity. The application opens up a new intervention path for the neurodevelopment disorder diseases, especially the neurodevelopment disorder diseases caused by TBL1XR1 gene mutation.

One variation of a method for modeling neurological development includes: aggregating electroencephalography (EEG) data that comprise multiple EEG signals of each user in a set of users, EEG signals of each user recorded on multiple distinct dates, the set of users comprising a plurality of users of various known neurological statuses; identifying a synchronization pattern trend within the EEG data of the set of users; and correlating the synchronization pattern trend with neurological development within the set of users.

The invention belongs to the technical field of regenerative medicine, and discloses an organoid culture method derived from neural stem cells in subventricular regions of human and non-human primates. By optimizing a culture medium formula and regulating and controlling transcription factors, the organoid is successfully induced to be differentiated into the neuron precursor for expressing the CRABP1. The cell expresses TAC3, the limitation of the prior art in simulation of special neuropedigree and complex brain structure of primates is overcome, and a breakthrough in-vitro model is provided for research on neurodevelopment and nervous system diseases and drug development. The established system not only can provide a new tool for researching the development law and disease mechanism of the primate nervous system, but also can provide a reliable experimental platform and a transplantable cell source for developing targeted drugs, constructing advanced disease models and developing cell replacement therapy.

The invention discloses a micro electrical stimulation nerve conduit and a preparation method thereof. The nerve conduit prepared by the invention has good medical value on nerve injury repair and nerve transplantation function repair through various ways of establishing a mechanical space, supplementing nerve growth factors, performing electrical stimulation on nerve development and the like. The whole nerve conduit is made of a degradable material and is degraded in vivo after the effect is achieved, and a secondary mechanical taking operation is avoided. Metal is embedded in the two ends of the catheter, micro-current stimulation is generated in a self-source mode by utilizing the corrosion potential difference of different metals and taking body fluid as electrolyte, nerve development is promoted, and the safety and miniaturization of the catheter with the same effect are improved. The fiber membrane is arranged on the inner-layer tube body, so that the carried nerve growth factors can be slowly released, and nutrients required by nerve growth can be provided; the fiber membrane is rolled to be cylindrical, so that the nerve can grow along the catheter in an adhesion manner, and the regeneration efficiency of nervous tissues is improved.

The invention relates to a construction method and application of a zebrafish reln gene knockout model. According to the method, a sixth exon of a reln gene of the zebra fish is targeted through a CRISPR / Cas9 technology, and a stable passage reln mutant zebra fish model is generated. The method comprises the steps of gene knockout, mutant identification, expression pattern analysis, microscopic morphology observation and nerve electrophysiology testing. The model can be used for researching neurodevelopment abnormality caused by Reelin protein deletion, such as neuron migration defect and epilepsy phenotype, and an efficient and stable platform is provided for nervous system disease mechanism research and drug screening. The method integrates multi-dimensional verification means, is easy and convenient to operate and high in repeatability, and has important application value.

This invention provides a polypeptide and hydrolyzed casein with neuroprotective effects. The polypeptide AWPQ of this invention can be absorbed by the intestines after ingestion and crosses the blood-brain barrier to enter the central nervous system, thereby promoting the growth, development, and differentiation of nerve cells and ultimately exerting its neuroprotective effect. It has good development prospects in the fields of functional foods or bioactive peptides related to brain health, neuroprotection, and nerve development.

The application discloses a new-born brain function evaluation and neural development prognosis prediction system, relates to the technical field of new-born brain function evaluation, and comprises an EEG electrode module, an fNIRS optical electrode module and a prediction module. The EEG electrode module is used for collecting EEG signals of a new-born in real time within a set time period. The fNIRS optical electrode module is used for collecting rSO2 signals of the new-born in real time within the set time period. The prediction module is used for performing signal preprocessing on EEG signals of the whole brain of the new-born and the rSO2 signals of the new-born, obtaining preprocessed EEG signals and preprocessed rSO2 signals, generating a dynamic brain function connection network sequence capable of representing the time evolution characteristics of brain function connection structures by using the preprocessed EEG signals and the preprocessed rSO2 signals, obtaining a time-varying feature vector by using the dynamic brain function connection network sequence, and obtaining a prediction result of new-born brain function evaluation and neural development prognosis based on the time-varying feature vector and a prediction model established in advance.

A method for treating or reducing the severity of neurodevelopmental defects in a developing nervous system after exposure to an anesthetic by modulating or inhibiting caspase activity, for example, by administering a pan-caspase inhibitor such as pan-caspase inhibitor Q-VD-OPh to a subject having or at risk of congestive heart disease and / or having a ciliopathic disorder.

The invention discloses a neurodevelopmental disorder risk prediction system based on a structural magnetic resonance image and cortex-subcortex joint representation learning. The system comprises a cortex feature extraction module, a subcortex feature extraction module, a semantic consistency constraint module and a diagnosis output module. The cortex feature extraction module is responsible for processing cortex surface data and extracting cortex morphological features through a spherical convolutional neural network; the sub-cortex feature extraction module is responsible for processing sub-cortex volume data and extracting sub-cortex structure features through a three-dimensional convolutional neural network; the two modules both adopt a metadata-perceived text encoder, clinical metadata is converted into text embedding, heterogeneous cortex features and sub-cortex features are mapped into a unified semantic space through a contrast learning strategy, and cross-characterization semantic alignment is achieved; through a semantic consistency constraint module, it is ensured that specific projection heads of the two areas generate semantic consistency explanations, and finally a corresponding prediction result is output through a diagnosis output module. According to the invention, the system has higher accuracy and generalization ability in neurodevelopment disorder detection.

The invention relates to the technical field of basic medicine, and discloses a base and dynamic monitoring system for newborn mouse stereotactic injection, the base comprises a stereotactic instrument, the stereotactic instrument also comprises a test platform, the upper surface of the test platform is provided with a base, the contact surface of the base and the test platform is provided with a connecting mechanism, and the connecting mechanism is connected with the stereotactic instrument. The base is used for detachably fixing the base to the upper surface of a test platform, an anesthesia module is arranged at the front end of the base, and a monitoring module is arranged in the base. Through cooperative work of the base and a dynamic monitoring system, the stability and the operation precision of the injection process are remarkably improved, the injury risk of experimental animals is effectively reduced, and the safety of the experimental animals is improved. Reliable technical support is provided for development of stereotactic intervention research of early brain development, and a solid experimental foundation is laid for deep exploration of pathological mechanisms of neurodevelopment-related diseases.