Camellia whitening soft mask

Abstract

The invention discloses a camellia whitening soft mask which is prepared from the following components in percentage by weight: a camellia extract, nicotinamide, sodium hyaluronate, a glycyrrhiza glabra root extract, carboxymethyl cellulose, glycerol, a preservative and the balance of deionized water. A triple whitening pathway is formed by compounding the camellia extract, the nicotinamide and the glycyrrhiza glabra root extract, and long-acting slow release is achieved in cooperation with the carboxymethyl cellulose / glycerin colloid matrix. In the preparation process, supercritical extraction and cold preparation processes are adopted, active ingredients are reserved to the maximum extent, and the product has a remarkable whitening effect and good skin compatibility.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of biotechnology and cosmetic technology, and particularly relates to a camellia white soft mask. BACKGROUND

[0002] With the existing whitening mask mostly using chemical synthetic ingredients (such as arbutin, hydroquinone derivatives), there are problems of great irritation and high risk of sensitization.

[0003] The plant whitening mask disclosed in patent CN202010789012.3 relies on vitamin C derivatives, but its light stability is poor and excessive preservatives need to be added. Traditional soft mask preparation adopts high-temperature sterilization process, resulting in a large loss of heat-sensitive active ingredients (such as polyphenols). A camellia white soft mask with natural sources, mildness, no irritation and synergistic effect is developed, and the active ingredients are preserved through low-temperature cold preparation process. SUMMARY

[0004] In order to solve the technical problems in the background art, the present application provides a camellia white soft mask, particularly relates to a whitening soft mask taking camellia extract as a core component and a low-temperature cold preparation process thereof, which is particularly suitable for facial skin whitening, moisturizing and antioxidant care.

[0005] A camellia white soft mask, which contains the following components in percentage by weight:

[0006] Camellia extract 3-15%

[0007] Nicotinamide 1-5%

[0008] Sodium hyaluronate 0.1-2%

[0009] Glycyrrhiza glabra root extract 0.5-3%

[0010] Carboxymethyl cellulose 2-8%

[0011] Glycerin 5-15%

[0012] Preservative 0.1-0.5%

[0013] and the balance is deionized water.

[0014] Further, the camellia white soft mask contains the following components in percentage by weight:

[0015] Camellia extract 3-15%

[0016] Nicotinamide 1-5%

[0017] Sodium hyaluronate 0.1-2%

[0018] Glycyrrhiza glabra root extract 0.5-3%

[0019] Carboxymethyl cellulose 2-8%

[0020] Glycerin 5-15%

[0021] Preservative 0.1-0.5%

[0022] and the balance is deionized water.

[0023] Further, the Camellia white soft film contains the following components by weight percentage:

[0024] Camellia extract 3-15%

[0025] Nicotinamide 1-5%

[0026] Sodium hyaluronate 0.1-2%

[0027] Glycyrrhiza glabra root extract 0.5-3%

[0028] Carboxymethyl cellulose 2-8%

[0029] Glycerin 5-15%

[0030] Preservative 0.1-0.5%

[0031] and the balance is deionized water.

[0032] Further, the Camellia extract is obtained by supercritical CO2 extraction process, with extraction pressure of 20-30 MPa and temperature of 30-40℃.

[0033] A preparation method of a Camellia white soft film, the component preparation of the Camellia white soft film includes the following steps:

[0034] (1) Pre-dispersion

[0035] Carboxymethyl cellulose as a water-soluble polymer, plays a role in building the framework in the soft film, and its dosage is controlled at 2-8% to form a three-dimensional network structure with appropriate viscosity;

[0036] Glycerin as a small molecule humectant, mixed with carboxymethyl cellulose at a ratio of 5-15%, promotes the stretching of carboxymethyl cellulose molecular chain through hydrogen bonding, reduces the viscosity of the system and improves the plasticity;

[0037] Carboxymethyl cellulose and glycerin are pre-mixed in a water bath at 40-45℃, which can accelerate the swelling of carboxymethyl cellulose and avoid molecular chain degradation caused by high temperature;

[0038] The stirring speed is controlled at 200-500 rpm for 15-20 min, until the system presents a uniform translucent colloidal state without visible particulate matter.

[0039] (2) Low temperature extraction

[0040] Using supercritical CO2 fluid, set pressure 25 MPa, temperature 35℃, its diffusion coefficient is 10-100 times of ordinary solvent, can penetrate plant cell wall to realize full component extraction;

[0041] Carrier selection: add 5% volume fraction of ethanol as a polarity regulator to improve the dissolution rate of polar substances such as flavonoids and tea polyphenols;

[0042] The whole process temperature is controlled to be less than 40℃ to avoid thermal decomposition of heat-sensitive components (such as sasanquasaponin), and the retention rate of polyphenols in the extract can reach 98.2%;

[0043] The extraction time is set to 120 min, and HPLC detection shows that the content of characteristic components such as kaempferol and quercetin reaches the peak value under this condition;

[0044] (3) Cold preparation process

[0045] The operating environment temperature is strictly controlled to be less than 30℃ to prevent the hydrolysis of nicotinamide to generate nicotinic acid at high temperature, resulting in increased irritation;

[0046] Addition sequence: preferentially add glycyrrhiza glabra root extract (pH sensitive component), and then add sodium hyaluronate (shear sensitive component) to avoid local concentration too high causing aggregation;

[0047] Use high shear homogenizer (3000 rpm, 10 min), shear rate reaches 10^4 s -1 , so that the particle size distribution D90≤50μm, ensuring uniform dispersion of active ingredients;

[0048] Dynamic viscosity detection: the system viscosity should be maintained at 8000-12000 mPa·s at 25℃ after homogenization, meeting the requirements of soft film spreading and film forming;

[0049] (4) Defoaming treatment

[0050] The vacuum degree is set to -0.08 MPa, under this pressure the bubble volume expands to 12 times of the original volume, accelerating the rupture and escape;

[0051] Defoaming time 20 min, microscopic observation shows that the residual rate of bubbles is less than 0.1%, meeting the requirements of optical transparency of the paste;

[0052] Centrifugal test: no stratification phenomenon after 3000 rpm centrifugation for 30 min, proving that the colloidal structure after defoaming is dense, and the stability of solid-liquid two phases meets the requirements;

[0053] Rheological property: the Thixotropy Index of the paste after defoaming is 1.2-1.5, indicating that the paste has suitable shear thinning property and is easy to be coated.

[0054] Further, the low-temperature cold mixing process step: the temperature of adding all active ingredients is controlled at 25-30℃, and the homogenization speed is 2500-3500 rpm.

[0055] Beneficial effects:

[0056] After one month of use by a plurality of volunteers, the average melanin index (MI) decreased by 18.7% (p<0.01); after storage at 40℃ / 75% RH for 3 months, the paste was not layered, and the retention rate of the active ingredients was >95%. DETAILED DESCRIPTION

[0057] In order to make the purpose, technical scheme and advantages of the present application more clear, the present application is further described in detail. It should be understood that the specific examples described herein are only used to explain the present application, and are not used to limit the present application.

[0058] Example 1: A Camellia white soft film, which comprises the following components by weight percentage:

[0059] Camellia extract 3%

[0060] Nicotinamide 1%

[0061] Sodium hyaluronate 0.1%

[0062] Glycyrrhiza glabra root extract 0.5%

[0063] Carboxymethyl cellulose 2%

[0064] Glycerol 5%

[0065] Preservative 0.1%

[0066] and the balance is deionized water.

[0067] Further, the Camellia extract is obtained by supercritical CO2 extraction process, the extraction pressure is 20 MPa, and the temperature is 30℃.

[0068] A preparation method of a Camellia white soft film, the component preparation of the Camellia white soft film comprises the following steps:

[0069] (1) Pre-dispersion

[0070] Carboxymethyl cellulose, as a water-soluble polymer, plays a role in building a framework in the soft film, and when its amount is controlled at 2%, a three-dimensional network structure with suitable viscosity can be formed;

[0071] Glycerin, as a small molecule humectant, mixed with carboxymethyl cellulose at a ratio of 5%, promotes the stretching of carboxymethyl cellulose molecular chains through hydrogen bonding, reducing the viscosity of the system and increasing plasticity;

[0072] Carboxymethyl cellulose and glycerin are pre-mixed in a 40°C water bath. This temperature range can accelerate the swelling of carboxymethyl cellulose and avoid molecular chain degradation caused by high temperature;

[0073] The stirring speed is controlled at 200 rpm for 15 minutes, until the system presents a uniform translucent gel state without visible particulate matter;

[0074] (2) Low temperature extraction

[0075] Supercritical CO2 fluid (pressure 25 MPa, temperature 35°C) is used, with a diffusion coefficient 10-100 times that of ordinary solvents, which can penetrate plant cell walls to achieve full component extraction;

[0076] Carrier selection: Add 5% volume fraction of ethanol as a polarity regulator to improve the dissolution rate of polar substances such as flavonoids and tea polyphenols;

[0077] The temperature is controlled throughout the process to be less than 40°C to avoid thermal decomposition of heat-sensitive components such as camellia saponins, and the retention rate of polyphenols in the extract can reach 98.2%;

[0078] The extraction time is set to 120 minutes, and HPLC detection shows that the content of characteristic components such as kaempferol and quercetin reaches a peak under this condition;

[0079] (3) Cold preparation process

[0080] The operating environment temperature is strictly controlled at <30°C to prevent the hydrolysis of nicotinamide to generate nicotinic acid at high temperature, leading to increased irritation;

[0081] Addition sequence: Preferably add Glycyrrhiza glabra root extract (pH-sensitive components), then add sodium hyaluronate (shear-sensitive components) to avoid local concentration too high causing aggregation;

[0082] Use a high-shear homogenizer (3000 rpm, 10 min) with a shear rate of 10^4 s -1 to ensure uniform dispersion of active ingredients with a particle size distribution D90 ≤ 50 μm;

[0083] Dynamic viscosity detection: The system viscosity should be maintained at 8000-12000 mPa·s at 25°C after homogenization, meeting the requirements of soft film spreading and film forming;

[0084] (4) Defoaming treatment

[0085] The vacuum degree is set to -0.08 MPa, at which pressure the bubble volume expands to 12 times the original volume, accelerating the rupture and escape;

[0086] Debubbling time 20 min, residual bubble rate <0.1% by microscope observation, meeting the requirement of optical transparency of the paste;

[0087] Centrifugal test: no delamination after 3000 rpm centrifugation for 30 min, proving that the colloidal structure is compact after debubbling and the stability of solid-liquid two phases meets the standard;

[0088] Rheological property: Thixotropy Index of the paste after debubbling is 1.2-1.5, indicating that it has suitable shear thinning property and is convenient for coating.

[0089] Further, the low-temperature cold preparation process step: the temperature of all active ingredients is controlled at 25-30℃, and the homogenization speed is 2500 rpm.

[0090] Example 2: A Camellia white soft film, which comprises the following components by weight percentage:

[0091] Camellia extract 9%

[0092] Nicotinamide 3%

[0093] Sodium hyaluronate 1%

[0094] Glycyrrhiza glabra root extract 1.75%

[0095] Carboxymethyl cellulose 5%

[0096] Glycerol 10%

[0097] Preservative 0.3%

[0098] and the balance is deionized water.

[0099] Further, the Camellia extract is obtained by supercritical CO2 extraction process, with extraction pressure of 25 MPa and temperature of 35℃.

[0100] A preparation method of a Camellia white soft film, the component preparation of the Camellia white soft film comprising the following steps:

[0101] (1) Pre-dispersion

[0102] Carboxymethyl cellulose as a water-soluble polymer, plays a role in building the framework in the soft film, and when its amount is controlled at 2-8%, a three-dimensional network structure with suitable viscosity can be formed;

[0103] Glycerol as a small molecule humectant, when mixed with carboxymethyl cellulose at a ratio of 10%, promotes the stretching of carboxymethyl cellulose molecular chain through hydrogen bonding, reduces the viscosity of the system and improves plasticity;

[0104] Carboxymethyl cellulose and glycerol were premixed in a water bath at 42.5℃, which can accelerate the swelling of carboxymethyl cellulose and avoid molecular chain degradation caused by high temperature;

[0105] The stirring speed was controlled at 250 rpm for 18 min, until the system appeared uniform and translucent colloidal, and no visible particulate matter was observed;

[0106] (2) Low temperature extraction

[0107] Supercritical CO2 fluid (pressure 25 MPa, temperature 35℃) was used, with a diffusion coefficient 10-100 times that of ordinary solvents, which can penetrate plant cell walls to achieve full component extraction;

[0108] Carrier selection: Add 5% volume fraction of ethanol as a polarity regulator to improve the dissolution rate of polar substances such as flavonoids and tea polyphenols;

[0109] The whole process was controlled at a temperature <40℃ to avoid thermal decomposition of heat-sensitive components (such as sasanquasaponin), and the retention rate of polyphenols in the extract can reach 98.2%;

[0110] The extraction time was set to 120 min, and HPLC detection showed that the content of characteristic components such as kaempferol and quercetin reached a peak under this condition;

[0111] (3) Cold preparation process

[0112] The operating environment temperature was strictly controlled at <30℃ to prevent the hydrolysis of nicotinamide to generate nicotinic acid at high temperature, resulting in increased irritation;

[0113] Addition sequence: Preferably add Glycyrrhiza glabra root extract (pH sensitive component), then add sodium hyaluronate (shear sensitive component) to avoid local concentration too high causing aggregation;

[0114] High shear homogenizer (3000 rpm, 10 min) was used, with a shear rate of 10^4 s -1 , so that the particle size distribution D90≤50μm, ensuring uniform dispersion of active ingredients;

[0115] Dynamic viscosity detection: The viscosity of the system after homogenization at 25℃ should be maintained at 8000-12000 mPa·s, meeting the requirements of soft film spreading and film forming;

[0116] (4) Defoaming treatment

[0117] The vacuum degree was set to -0.08 MPa, at which pressure the bubble volume expanded to 12 times the original volume, accelerating the rupture and escape;

[0118] Defoaming time 20 min, microscopic observation showed that the residual rate of bubbles was <0.1%, meeting the requirements of optical transparency of the paste;

[0119] Centrifugal test: no delamination phenomenon after centrifugation at 3000 rpm for 30 min, which proves that the colloidal structure is compact after defoaming, and the stability of solid-liquid two phases meets the standard;

[0120] Rheological property: the Thixotropy Index of the paste after defoaming is 1.2-1.5, which indicates that it has suitable shear thinning properties and is easy to coat.

[0121] Further, the low-temperature cold preparation process step: the temperature of all active ingredients is controlled at 25-30℃, and the homogenization speed is 3000 rpm.

[0122] Example 3: A Camellia white soft film, which comprises the following components by weight percentage:

[0123] Camellia extract 15%

[0124] Nicotinamide 5%

[0125] Sodium hyaluronate 2%

[0126] Glycyrrhiza glabra root extract 3%

[0127] Carboxymethyl cellulose 8%

[0128] Glycerol 15%

[0129] Preservative 0.5%

[0130] and the balance is deionized water.

[0131] Further, the Camellia extract is obtained by supercritical CO2 extraction process, the extraction pressure is 30 MPa, and the temperature is 40℃.

[0132] A preparation method of a Camellia white soft film, the component preparation of the Camellia white soft film comprises the following steps:

[0133] (1) Pre-dispersion

[0134] Carboxymethyl cellulose as a water-soluble polymer, plays a role in building the framework in the soft film, and when its amount is controlled at 8%, a three-dimensional network structure with suitable viscosity can be formed;

[0135] Glycerol as a small molecule humectant, when mixed with carboxymethyl cellulose at a ratio of 15%, promotes the stretching of carboxymethyl cellulose molecular chain through hydrogen bond interaction, reduces the viscosity of the system and improves the plasticity;

[0136] Carboxymethyl cellulose and glycerol are pre-mixed in a water bath at 45℃, which can accelerate the swelling of carboxymethyl cellulose and avoid molecular chain degradation caused by high temperature;

[0137] Stirring speed control at 500 rpm, 20 min, to the system presents a uniform translucent gel, no visible particles;

[0138] (2) Low temperature extraction

[0139] The use of supercritical CO2 fluid (pressure 25 MPa, temperature 35 ℃), its diffusion coefficient is 10-100 times of ordinary solvents, can penetrate the plant cell wall to achieve full component extraction;

[0140] The entrainer is selected: add 5% volume fraction of ethanol as a polar modifier to improve the dissolution rate of flavonoids, tea polyphenols and other polar substances;

[0141] The whole process temperature control <40 ℃, to avoid the thermal decomposition of heat-sensitive components (such as sasanquasaponin), the retention rate of polyphenols in the extract can reach 98.2%;

[0142] The extraction time is set to 120 min, and HPLC detection shows that the content of characteristic components such as kaempferol and quercetin reaches the peak under this condition;

[0143] (3) Cold configuration process

[0144] The operating environment temperature is strictly controlled at <30 ℃ to prevent the hydrolysis of nicotinamide to generate nicotinic acid at high temperature, resulting in increased irritation;

[0145] The addition sequence is: preferentially adding Glycyrrhiza glabra root extract (pH sensitive component), and then adding sodium hyaluronate (shear sensitive component), to avoid local concentration too high causing aggregation;

[0146] The high shear homogenizer (3000 rpm, 10 min) is used, and the shear rate reaches 10^4 s -1 , so that the particle size distribution D90≤50 μm, ensuring uniform dispersion of active ingredients;

[0147] Dynamic viscosity detection: the viscosity of the system after homogenization at 25 ℃ should be maintained at 8000-12000 mPa·s, meeting the requirements of soft film spreading and film forming;

[0148] (4) Defoaming treatment

[0149] The vacuum degree is set to -0.08 MPa, and under this pressure, the bubble volume expands to 12 times the original volume, accelerating the rupture and escape;

[0150] The defoaming time is 20 min, and the microscope observation shows that the residual rate of bubbles is <0.1%, meeting the requirements of optical transparency of the paste;

[0151] Centrifugal test: no stratification phenomenon after 3000 rpm centrifugation for 30 min, proving that the colloidal structure after defoaming is dense, and the stability of solid-liquid two phases meets the standard;

[0152] Rheological properties: the Thixotropy Index of the paste after defoaming is 1.2-1.5, indicating that it has suitable shear thinning properties and is easy to coat.

[0153] Further, the low-temperature cold preparation process step: the temperature of all active ingredients is controlled at 30°C, and the homogenization speed is 3500 rpm.

[0154] Example 4

[0155] A camellia white soft film, which comprises the following components by weight percentage:

[0156] Camellia extract 5%

[0157] Nicotinamide 2%

[0158] Sodium hyaluronate 0.5%

[0159] Glycyrrhiza glabra root extract 1%

[0160] Carboxymethyl cellulose 3%

[0161] Glycerol 8%

[0162] Preservative 0.2%

[0163] and the balance is deionized water.

[0164] Further, the camellia extract is obtained by supercritical CO2 extraction process, the extraction pressure is 22 MPa, and the temperature is 34°C.

[0165] A preparation method of a camellia white soft film, the component preparation of the camellia white soft film comprises the following steps:

[0166] (1) Pre-dispersion

[0167] Carboxymethyl cellulose as a water-soluble polymer, plays a role in building the framework in the soft film, and when the amount is controlled at 3%, a three-dimensional network structure with suitable viscosity can be formed;

[0168] Glycerol as a small molecule humectant, mixed with carboxymethyl cellulose at a ratio of 8%, promotes the stretching of carboxymethyl cellulose molecular chain through hydrogen bonding, reduces the viscosity of the system and improves the plasticity;

[0169] Carboxymethyl cellulose and glycerol are pre-mixed in a water bath at 42°C, this temperature range can accelerate the swelling of carboxymethyl cellulose and avoid molecular chain degradation caused by high temperature;

[0170] The stirring speed is controlled at 250 rpm for 17 min, until the system presents a uniform translucent colloidal state without visible particulate matter;

[0171] (2) Low temperature extraction

[0172] Supercritical CO2 fluid (25 MPa pressure, 35℃ temperature) is used, which has a diffusion coefficient 10-100 times that of ordinary solvents, and can penetrate plant cell walls to achieve full component extraction;

[0173] Carrier selection: Add 5% volume fraction of ethanol as a polarity regulator to improve the dissolution rate of polar substances such as flavonoids and tea polyphenols;

[0174] The whole process is temperature controlled at <40℃ to avoid thermal decomposition of heat-sensitive components (such as sasanquasaponin), and the retention rate of polyphenols in the extract can reach 98.2%;

[0175] The extraction time is set to 120 minutes, and HPLC detection shows that the content of characteristic components such as kaempferol and quercetin reaches a peak under this condition;

[0176] (3) Cold preparation process

[0177] The operating environment temperature is strictly controlled at <30℃ to prevent the hydrolysis of nicotinamide to generate nicotinic acid at high temperature, resulting in increased irritation;

[0178] Addition sequence: Preferentially add Glycyrrhiza glabra root extract (pH-sensitive components), and then add sodium hyaluronate (shear-sensitive components) to avoid local concentration too high causing aggregation;

[0179] Use a high-shear homogenizer (3000 rpm, 10 min) with a shear rate of 10^4 s -1 , so that the particle size distribution D90≤50μm, ensuring uniform dispersion of active ingredients;

[0180] Dynamic viscosity detection: The system viscosity should be maintained at 8000-12000 mPa·s at 25℃ after homogenization, meeting the requirements of soft film spreading and film forming;

[0181] (4) Defoaming treatment

[0182] The vacuum degree is set to -0.08 MPa, at which pressure the bubble volume expands to 12 times the original volume, accelerating the escape of the bubble;

[0183] Defoaming time 20 min, microscopic observation shows that the bubble residual rate is <0.1%, meeting the requirements of optical transparency of the paste;

[0184] Centrifugal test: No stratification phenomenon after 3000 rpm centrifugation for 30 min, proving that the colloidal structure after defoaming is dense, and the stability of solid-liquid two phases meets the standard;

[0185] Rheological property: the Thixotropy Index of the paste after defoaming is 1.2-1.5, indicating that it has suitable shear thinning property and is easy to be coated.

[0186] Further, the low-temperature cold preparation process step: the temperature of all active ingredients is controlled at 26℃, and the homogenization speed is 2800rpm.

[0187] Example 5

[0188] A camellia white soft film, which comprises the following components by weight percentage:

[0189] Camellia extract 12%

[0190] Nicotinamide 4%

[0191] Sodium hyaluronate 1.5%

[0192] Glycyrrhiza glabra root extract 2%

[0193] Carboxymethyl cellulose 6%

[0194] Glycerol 12%

[0195] Preservative 0.4%

[0196] and the balance is deionized water.

[0197] Further, the camellia extract is obtained by supercritical CO2 extraction process, the extraction pressure is 28MPa, and the temperature is 38℃.

[0198] A preparation method of a camellia white soft film, the component preparation of the camellia white soft film comprises the following steps:

[0199] (1) Pre-dispersion

[0200] Carboxymethyl cellulose, as a water-soluble polymer, plays a role in building the framework in the soft film, and when its amount is controlled at 6%, a three-dimensional network structure with suitable viscosity can be formed;

[0201] Glycerol, as a small molecule humectant, is mixed with carboxymethyl cellulose at a proportion of 12%, and then promotes the stretching of carboxymethyl cellulose molecular chain through hydrogen bond interaction, reduces the viscosity of the system and improves the plasticity;

[0202] Carboxymethyl cellulose and glycerol are pre-mixed in a water bath at 44℃, which can accelerate the swelling of carboxymethyl cellulose and avoid molecular chain degradation caused by high temperature;

[0203] The stirring speed is controlled at 450rpm for 18min, until the system presents a uniform translucent colloidal state without visible particulate matter;

[0204] (2) Low temperature extraction

[0205] Supercritical CO2 fluid (pressure 25 MPa, temperature 35℃) is used, which has a diffusion coefficient 10-100 times that of ordinary solvents, can penetrate plant cell walls and achieve full component extraction;

[0206] Carrier selection: Add 5% volume fraction of ethanol as a polarity regulator to improve the dissolution rate of polar substances such as flavonoids and tea polyphenols;

[0207] The whole process is temperature controlled <40℃, to avoid thermal decomposition of heat-sensitive components (such as sasanquasaponin), and the retention rate of polyphenols in the extract can reach 98.2%;

[0208] The extraction time is set to 120 minutes, and HPLC detection shows that the content of characteristic components such as kaempferol and quercetin reaches a peak under this condition;

[0209] (3) Cold preparation process

[0210] The operating environment temperature is strictly controlled at <30℃ to prevent the hydrolysis of nicotinamide to generate nicotinic acid at high temperature, resulting in increased irritation;

[0211] Addition sequence: Preferably add Glycyrrhiza glabra root extract (pH sensitive component), then add sodium hyaluronate (shear sensitive component), to avoid local concentration too high causing aggregation;

[0212] Use a high-shear homogenizer (3000 rpm, 10 min), with a shear rate of 10^4 s -1 , so that the particle size distribution D90≤50μm, to ensure uniform dispersion of active ingredients;

[0213] Dynamic viscosity detection: The system viscosity should be maintained at 8000-12000 mPa·s at 25℃ after homogenization, meeting the requirements of soft film spreading and film forming;

[0214] (4) Defoaming treatment

[0215] The vacuum degree is set to -0.08 MPa, at which pressure the bubble volume expands to 12 times the original volume, accelerating the rupture and escape;

[0216] Defoaming time 20 min, microscopic observation shows that the bubble residual rate is <0.1%, meeting the optical transparency requirements of the paste;

[0217] Centrifugal test: No stratification phenomenon after 3000 rpm centrifugation for 30 min, proving that the colloidal structure after defoaming is dense, and the stability of solid-liquid two phases meets the standard;

[0218] Rheological properties: The Thixotropy Index of the paste after defoaming is 1.2-1.5, indicating that it has suitable shear thinning properties and is easy to coat.

[0219] Further, the low temperature cold process step: all active ingredients are added at a temperature control of 28°C, homogenization speed 3200 rpm.

[0220] The above description is merely preferred embodiments of the present application, and is not used to limit the present application. Any modification, equivalent replacement, and improvement made within the spirit and principle of the present application shall fall within the scope of protection of the present application.

Claims

1. A Camellia white soft film, characterized in that, The Camellia white soft film comprises the following components by weight percentage: Camellia extract 3-15% Nicotinamide 1-5% Sodium hyaluronate 0.1-2% Glycyrrhiza glabra root extract 0.5-3% Carboxymethyl cellulose 2-8% Glycerin 5-15% Preservative 0.1-0.5% and the balance is deionized water.

2. The Camellia white soft film according to claim 1, characterized in that, The Camellia white soft film comprises the following components by weight percentage: Camellia extract 5-12% Nicotinamide 2-4% Sodium hyaluronate 0.5-1.5% Glycyrrhiza glabra root extract 1-2% Carboxymethyl cellulose 3-6% Glycerin 8-12% Preservative 0.2-0.4% and the balance is deionized water.

3. The Camellia white soft film according to claim 1 or 2, characterized in that, The Camellia white soft film comprises the following components by weight percentage: Camellia extract 9% Nicotinamide 3% Sodium hyaluronate 1% Glycyrrhiza glabra root extract 1.75% Carboxymethyl cellulose 5% Glycerin 10% Preservative 0.3% and the balance is deionized water.

4. The Camellia white soft film according to claim 1, 2 or 3, characterized in that, The Camellia extract is obtained by supercritical CO2 extraction process, with extraction pressure of 20-30 MPa and temperature of 30-40℃.

5. A method of preparing the Camellia white soft film according to claim 1, 2 or 3, characterized in that, The preparation of the components of the Camellia white soft film comprises the following steps: (1) Pre-dispersion Add 2-8% carboxymethyl cellulose as a water-soluble polymer to form a three-dimensional network structure with suitable viscosity; Add 5-15% glycerin as a small molecule humectant, which promotes the carboxymethyl cellulose molecular chain after mixing with carboxymethyl cellulose through hydrogen bonding; Pre-mix carboxymethyl cellulose and glycerin in a water bath at 40-45℃ according to the proportion; Control the stirring speed at 200-500 rpm for 15-20 min, until the system presents a uniform translucent gel state without visible particulate matter; (2) Low-temperature extraction Use supercritical CO2 fluid, set the pressure to 25 MPa and the temperature to 35℃; Choose a carrier: add 5% volume fraction of ethanol as a polarity regulator; Control the temperature throughout the process to be <40℃; Set the extraction time to 120 min; (3) Cold compounding process Strictly control the operating environment temperature to be <30℃; Add the components in the following order: preferentially add the Glycyrrhiza glabra root extract (pH sensitive component), and then add the sodium hyaluronate; A high shear homogenizer was used, set at 3000 rpm for 10 min, with a shear rate of 10^4 s -1 to give a particle size distribution D90≤ 50 μm; Dynamic viscosity detection: the system viscosity should be maintained at 8000-12000 mPa·s after homogenization at 25℃, meeting the requirements of soft film spreadability and film-forming property; (4) Defoaming treatment Set the vacuum degree to -0.08 MPa, at which pressure the bubble volume expands to 12 times the original volume, accelerating the escape of the bubbles; Defoaming time is 20 min, and microscopic observation shows that the residual bubble rate is <0.1%, meeting the optical transparency requirements of the paste; Centrifugal test: no stratification phenomenon after centrifugation at 3000 rpm for 30 min; Rheological property: the Thixotropy Index of the paste after defoaming is 1.2-1.

5.

6. The method of claim 8, wherein, Low-temperature cold compounding process step: control the temperature of all active ingredients to be added to 25-30℃, and the homogenization speed to be 2500-3500 rpm.