Chrysanthemum blasting bead as well as preparation method and application thereof

Abstract

The invention provides a preparation method of chrysanthemum blasting beads, which comprises the following steps: adding sodium alginate powder into hydrogen-rich water for swelling, adding glycerol and span 20, and uniformly mixing to obtain a forming solution; mixing the sodium carboxymethyl cellulose with the hydrogen-rich water a to obtain a mixed solution a; uniformly mixing glycine, glycerol, calcium chloride and hydrogen-rich water b to obtain a mixed solution, and mixing the mixed solution a with the mixed solution to obtain a water phase; adding Arabic gum, chrysanthemum essential oil and menthol into liquid paraffin, and grinding to obtain an oil phase; mixing the water phase and the oil phase, and emulsifying by a grinding method to obtain O / W type emulsion; then preparing a chitosan solution; gelatin and tannic acid are added into purified water, glycerin is added after water-bath heating, and a gelatin liquid is obtained; dropwise adding the O / W type emulsion into the forming liquid, sequentially putting the obtained young blasting beads into a chitosan solution, a rubber liquid and dimethyl silicone oil, and washing to obtain the chrysanthemum blasting beads. The invention further provides application of the prepared chrysanthemum blasting beads in replaceable chrysanthemum blasting bead constant-temperature eyeshades.

Description

TECHNICAL FIELD

[0001] The application belongs to the technical field of explosive bead preparation, and particularly relates to a chrysanthemum explosive bead and a preparation method and application thereof. BACKGROUND

[0002] At present, there are various products on the market for relieving dry eye syndrome, but mainly in the form of taking and eye drops. It should be pointed out that the taking form has the limitation of slow effect, and often needs to be taken for a long time to see the effect, and the effect is not significant enough; and the eye drops may cause irritation or dependence to the eyes.

[0003] Therefore, there is an urgent need for an economical and efficient chrysanthemum explosive bead for relieving dry eye syndrome. SUMMARY

[0004] The technical problem to be solved by the application is to provide a chrysanthemum explosive bead and a preparation method and application thereof, which can solve the problems of the prior art.

[0005] To solve the above technical problems, the technical scheme adopted by the application is as follows: a preparation method of a chrysanthemum explosive bead, the preparation method comprising the following steps:

[0006] S1, preparation of a forming liquid: sodium alginate powder is added to hydrogen-rich water and swelled for a certain time, then stirred to a transparent gel, and then glycerol and Span 20 are added, and the mixture is continuously stirred and dispersed to obtain a forming liquid;

[0007] S2, preparation of an aqueous phase: first, glycine, glycerol, calcium chloride and hydrogen-rich water b are uniformly mixed to obtain a mixed liquid; carboxymethyl cellulose sodium is dissolved in hydrogen-rich water a to obtain a mixed liquid a; the mixed liquid a is added to the mixed liquid and uniformly mixed to obtain an aqueous phase;

[0008] S3, preparation of an oil phase: gum arabic, chrysanthemum essential oil and menthol are added to liquid paraffin, and the mixture is uniformly mixed by grinding to obtain an oil phase;

[0009] S4, preparation of a core material: the aqueous phase obtained in S2 is added to the oil phase obtained in S3, and then emulsified by a rapid grinding method to obtain an O / W emulsion;

[0010] S5, preparation of a chitosan solution: chitosan is added to purified water, and then the pH value is adjusted, and the mixture is stirred to dissolve to obtain a chitosan solution;

[0011] S6, the rubber liquid preparation: the gelatin and tannic acid into purified water, placed in a water bath constant temperature heating to the gelatin dissolves, then add glycerol a and stir evenly, get rubber liquid; the rubber liquid constant temperature storage for standby;

[0012] S7, the formation and curing of the explosion beads: the O / W emulsion obtained in S4 slowly into the forming liquid obtained in S1 crosslinking curing, get the explosion beads; the explosion beads are transferred to the chitosan solution obtained in S5 soak for a certain time, then placed in the rubber liquid obtained in S6 continue to soak, get the initial product; the initial product is placed in dimethyl silicone oil cooling, then washing, get the chrysanthemum explosion beads.

[0013] Preferably, the mass ratio of sodium alginate powder, hydrogen-rich water, glycerol and Span 20 in S1 is 1:50:2.5:0.1, the mass fraction of the hydrogen-rich water is 90-98%, the mass fraction of the glycerol is 1-10%; the swelling time is 2h, the magnetic stirring speed is 800rpm until the transparent gel, the dispersion stirring time is 5min.

[0014] Preferably, the mass ratio of glycine, glycerol, calcium chloride and hydrogen-rich water b in S2 is 0.2:4:0.4:10; the mass ratio of sodium carboxymethyl cellulose and hydrogen-rich water a is 0.4:30; the volume ratio of the mixed liquid a and the mixed liquid is 1:3.

[0015] Preferably, the mass ratio of gum arabic, chrysanthemum essential oil, menthol and liquid paraffin in S3 is 20:1:1:60, the mass fraction of the chrysanthemum essential oil is 0.1-2%; the mass fraction of the menthol is 0.1-2%; the preparation method of the chrysanthemum essential oil is: removing impurities and moldy parts from good quality chrysanthemum, then crushing to 40-60 mesh, then loading into the extraction kettle, using supercritical CO2 extraction, then resolving, obtaining the extract, separating the extract by reduced pressure distillation, obtaining the chrysanthemum essential oil; the extraction pressure is 25MPa, the temperature is 45℃, the time is 3-5h, the CO2 flow rate is set to 20L / h, and anhydrous ethanol is used as the entrainer; the resolving pressure is 5.5Mpa, the temperature is 40℃; the reduced pressure distillation temperature is 40-60℃, the time is 2-4h, the pressure is 0.05-0.1MPa.

[0016] Preferably, the volume ratio of the water phase and the oil phase in S4 is 1.2:1, the emulsification time is 5min.

[0017] Preferably, the mass fraction of chitosan in the chitosan solution in S5 is 1-10%, the pH value is adjusted to 5-6 with acetic acid, the stirring is magnetic stirring with a speed of 800rpm, and the stirring time is 1h.

[0018] Preferably, the mass fraction of the gelatin in the rubber solution in S6 is 10-40%, the mass fraction of the tannic acid in the rubber solution is 0-1%, the mass fraction of the glycerol a in the rubber solution is 10-30%, the temperature of the constant temperature heating of the water bath is 70 DEG C, and the rubber solution is stored at a constant temperature at 70 DEG C.

[0019] Preferably, the volume ratio of the O / W emulsion, the forming liquid, the chitosan solution and the rubber solution in S7 is 1:10:10:5; the O / W emulsion is slowly dropped into the forming liquid through a dropper at a rate of 2s / drop; the cross-linking and solidification time is 1h at 25 DEG C; the soaking time in the chitosan solution is 30min at 25 DEG C; the continuous soaking time in the rubber solution is 1min at 70 DEG C; the cooling temperature is 25 DEG C and the time is 30min; and the washing uses purified water.

[0020] The application further provides a chrysanthemum pearl prepared by the preparation method.

[0021] The application further provides application of the chrysanthemum pearl prepared by the preparation method in a replaceable chrysanthemum pearl constant-temperature eye cover.

[0022] Compared with the prior art, the application has the following advantages:

[0023] 1. The application forms a hydrogen-rich water-chrysanthemum essential oil-menthol-glycine-glycerol synergistic system, retains anti-inflammatory components (HPLC detection purity is greater than or equal to 95%) such as luteolin and chlorogenic acid in chrysanthemum by using supercritical CO2 extraction; glycine has multiple effects such as antioxidant, osmotic pressure regulation, and anti-inflammatory; glycerol has the effects of moisturizing, stabilizing and enhancing the stability of tear film, and prolonging the tear film break-up time; menthol can stimulate tear secretion by activating the cold-sensitive primary afferent neurons in the cornea, thereby increasing the amount of tear fluid and improving dry eye symptoms; the synergistic antioxidant and anti-inflammatory effects of hydrogen-rich water, and the formula can effectively relieve dry eye symptoms.

[0024] 2. The preparation method of the present application first mixes the water phase and the oil phase in a certain proportion through a specific emulsion pre-emulsification step, and emulsifies through a grinding method to form an O / W type emulsion, i.e. the core material. During the emulsification process, the ratio of the oil phase to the water phase is 1.2:1, and an O / W type emulsion is formed during the emulsification process. The calcium ions are distributed in the outer layer of the emulsion, which promotes the cross-linking reaction between the calcium ions and the sodium alginate in the forming liquid, so that the stable capsule skin is more easily formed. This process helps to improve the uniformity and stability of the burst beads, and the quality is better than that of the burst beads prepared by the conventional emulsification process.

[0025] 3. The preparation method of the present application uses hydrogen-rich water as a solvent in the preparation of the forming liquid, and liquid paraffin as a carrier in the oil phase. The selection of these natural raw materials not only meets the green environmental protection concept, but also matches the characteristics of chrysanthemum essential oil, and better plays its efficacy, which is different from the chemical synthetic solvent or carrier commonly used in the prior art.

[0026] 4. The preparation method of the present application combines the grinding method and the chemical gel method to prepare the burst beads, which does not need to use emulsifiers and drop pills, reduces the conditions and costs of preparing the burst beads, and at the same time, compared with the traditional burst beads containing only oily ingredients, the chrysanthemum burst beads prepared by the method of the present application innovatively contain oil phase and water phase at the same time, the components are more diversified, and the function of the burst beads can be expanded and strengthened.

[0027] 5. In the preparation method of the present application, liquid paraffin emulsion is used as a carrier, and by optimizing its prescription process, it is suitable for the preparation of burst beads. Unlike traditional emulsions that rely on high-speed shearing emulsification, this emulsion can achieve efficient emulsification only by grinding method, and the stability is significantly improved, and stratification phenomenon is not easy to occur. This not only greatly reduces the complexity and cost of experimental operation, but also provides a new idea and method for the preparation of burst beads by traditional chemical cross-linking method, which has important innovative significance.

[0028] 6. The present application uses the principle of electrostatic effect to realize the multi-layer coating of the burst beads. First, the prepared burst bead is placed in a chitosan solution. Since sodium alginate is an anionic polysaccharide and chitosan is a cationic polysaccharide, the two interact through electrostatic interaction, so that the chitosan layer is successfully coated on the surface of the burst bead, and a composite layer is constructed. This process not only makes up for the defects of the sodium alginate gel layer, such as poor mechanical properties and easy leakage, but also significantly enhances the mechanical strength and stability of the burst beads, and makes the surface layer of the burst beads have a positive charge. Subsequently, the burst beads coated with chitosan are placed in a mixed rubber solution containing gelatin and tannic acid. Both gelatin and tannic acid are negatively charged, and they adhere to the positively charged surface layer of the burst beads through electrostatic adsorption, forming a dense antibacterial film layer. This film layer not only endows the burst beads with antibacterial properties, but also further improves the flexibility of the burst beads due to the addition of glycerol in the gelatin, and reduces water evaporation, thereby preventing the burst beads from drying out due to water loss, and ensuring that the burst beads maintain good appearance and performance during storage and use. The preparation method of the present application has not been reported in the preparation of existing plant essential oil sustained-release burst beads.

[0029] 7. The specific amount and addition order of sodium alginate powder, glycerol and span 20 in the forming liquid, the ratio of sodium carboxymethyl cellulose, glycine, calcium chloride, glycerol and hydrogen-rich water in the aqueous phase, and the ratio of chrysanthemum essential oil, menthol and gum arabic in the oil phase in the preparation method of the present application are precisely optimized, which is crucial for realizing the excellent performance of the burst beads.

[0030] The present application will be further described in detail below in conjunction with the accompanying drawings and examples. BRIEF DESCRIPTION OF DRAWINGS

[0031] Figure 1 is a schematic diagram of the internal structure of the chrysanthemum burst beads prepared by the present application.

[0032] Figure 2 is a photograph of the chrysanthemum burst beads prepared by the present application.

[0033] Figure 3 is a schematic diagram of the replaceable chrysanthemum burst bead constant temperature eye mask in the present application.

[0034] Figure 4 is a particle size diagram of the burst bead, the burst bead immersed in the chitosan solution to form a chitosan film layer and the initial product prepared in Example 1 of the present application.

[0035] Figure 5 is a resilience diagram of the burst bead, the burst bead immersed in the chitosan solution to form a chitosan film layer and the initial product prepared in Example 1 of the present application. DETAILED DESCRIPTION

[0036] With reference to the accompanying drawings on the basis of the embodiments of the present application, the technical solutions in the embodiments of the present application will be clearly and completely described. Obviously, the described embodiments are only a part of the embodiments of the present application, rather than all the embodiments of the present application. Based on the embodiments of the present application, all the other embodiments obtained by a person of ordinary skill in the art without creative work fall within the protection scope of the present application.

[0037] Embodiment 1

[0038] The preparation method of the chrysanthemum explosion beads in the embodiment comprises the following steps:

[0039] S1, preparation of a molding liquid: sodium alginate powder is added into hydrogen-rich water to swell for 2 hours, then magnetically stirred at a speed of 800 rpm until transparent gel is obtained, then glycerol and Span 20 are added, and the stirring is continued for 5 minutes to disperse, and then a molding liquid is obtained;

[0040] The mass ratio of the sodium alginate, the hydrogen-rich water, the glycerol and the Span 20 is 1:50:2.5:0.1; the mass fraction of the hydrogen-rich water is 95%, and the mass fraction of the glycerol is 5%;

[0041] S2, preparation of an aqueous phase: first, glycine, glycerol, calcium chloride and hydrogen-rich water b are mixed uniformly according to a mass ratio of 0.2:4:0.4:10 to obtain a mixed liquid; then carboxymethyl cellulose sodium is dissolved in hydrogen-rich water a according to a mass ratio of 0.4:30 to obtain a mixed liquid a; the mixed liquid a is added into the mixed liquid and mixed uniformly to obtain an aqueous phase;

[0042] The volume ratio of the mixed liquid a to the mixed liquid is 1:3;

[0043] S3, preparation of an oil phase: gum arabic, chrysanthemum essential oil and menthol are added into liquid paraffin, and then mixed uniformly by grinding to obtain an oil phase;

[0044] The mass ratio of the gum arabic, the chrysanthemum essential oil, the menthol and the liquid paraffin is 20:1:1:60; the mass fraction of the chrysanthemum essential oil is 0.5%; and the mass fraction of the menthol is 0.5%;

[0045] The preparation method of the chrysanthemum essential oil is as follows: good quality chrysanthemum is removed from impurities and moldy parts, then crushed to a particle size of 50 mesh, then loaded into an extraction kettle, and then extracted by supercritical CO2, and then resolved to obtain an extract, and then the extract is separated by reduced pressure distillation to obtain chrysanthemum essential oil; the extraction pressure is 25 MPa, the temperature is 45℃, the time is 3-5 hours, the flow rate of CO2 is set to 20 L / h, and anhydrous ethanol is used as an entraining agent, the resolution pressure is 5.5 MPa, and the temperature is 40℃; the reduced pressure distillation temperature is 50℃, the time is 3 hours, and the pressure is 0.08 MPa.

[0046] S4, core material preparation: the water phase obtained in S2 is added to the oil phase obtained in S3 at a volume ratio of 1.2:1, and then emulsified by a rapid grinding method for 5 min to obtain an O / W emulsion;

[0047] The rapid grinding method is manual grinding with a mortar;

[0048] S5, chitosan solution preparation: chitosan is added to purified water, and then the pH value is adjusted to 5-6 with acetic acid, and the magnetic stirring is carried out at a speed of 800 rpm until the chitosan is dissolved to obtain a chitosan solution;

[0049] The mass fraction of chitosan in the chitosan solution is 5%;

[0050] S6, rubber solution preparation: gelatin and tannic acid are added to purified water, and then the water bath is placed in a water bath at a temperature of 70°C, and after the gelatin is dissolved, glycerol a is added and stirred uniformly to obtain a rubber solution; in order to prevent the rubber solution from solidifying, the rubber solution is stored at a constant temperature of 70°C for standby;

[0051] The mass fraction of gelatin in the rubber solution is 30%, the mass fraction of tannic acid in the rubber solution is 0.5%, and the mass fraction of glycerol a in the rubber solution is 20%;

[0052] S7, forming and curing of the blasting bead: the O / W emulsion obtained in S4 is slowly dropped into the forming liquid obtained in S1 through a dropper at a rate of 2 s / drop, and cross-linked and cured at a temperature of 25°C for 1 h to obtain a blasting bead embryo; the blasting bead embryo is transferred to the chitosan solution obtained in S5, soaked at a temperature of 25°C for 30 min to form a chitosan film layer, and then placed in the rubber solution obtained in S6 and soaked at a temperature of 70°C for 1 min to obtain a primary product; the primary product is placed in dimethyl silicone oil at a temperature of 25°C for 1 h, and then washed with purified water to remove the surface dimethyl silicone oil to obtain a chrysanthemum blasting bead;

[0053] The volume ratio of the O / W emulsion, the forming liquid, the chitosan solution and the rubber solution is 1:10:10:5. The chrysanthemum blasting bead prepared in the embodiment is as shown in Figure 2The mass fraction of the hydrogen-rich water in the embodiment S1 can also be 90%, 91%, 92%, 93%, 94%, 96%, 97% or 98%, the mass fraction of the glycerol can also be 1%, 2%, 3%, 4%, 6%, 7%, 8%, 9% or 10%; the mass fraction of the chrysanthemum essential oil in S3 can also be 0.1%, 0.2%, 0.3%, 0.4%, 0.6%, 0.7%, 0.8%, 0.9% or 2%; the mass fraction of the menthol can also be 0.1%, 0.2%, 0.3%, 0.4%, 0.6%, 0.7%, 0.8%, 0.9% or 2%; the mass fraction of the chitosan in S4 can also be 1%, 2%, 3%, 4%, 6%, 7%, 8%, 9% or 10%; the temperature of the reduced pressure distillation in S4 can also be 40℃, 41℃, 42℃, 44℃, 45℃, 47℃, 48℃, 49℃, 51℃, 53℃, 54℃, 55℃, 56℃, 57℃, 58℃, 59℃ or 60℃, the time can also be 2h, 2.2h, 2.3h, 2.5h, 2.6h, 2.7h, 2.8h, 2.9h, 3.1h, 3.3h, 3.5h, 3.6h, 3.7h, 3.8h, 3.9h or 4h, the pressure can also be 0.05MPa, 0.06MPa, 0.07MPa, 0.09MPa or 0.1MPa; the mass fraction of the gelatin in the gelatin solution in S6 can also be 10%, 12%, 13%, 14%, 15%, 17%, 19%, 20%, 25%, 27%, 29%, 32%, 33%, 34%, 35%, 36%, 38%, 39%, 40%, 41%, 42%, 43%, 44%, 45%, 46%, 47%, 48%, 49% or 50%, the mass fraction of the tannic acid in the gelatin solution can also be 0.1%, 0.2%, 0.3%, 0.4%, 0.6%, 0.7%, 0.8%, 0.9% or 2%, the mass fraction of the glycerol a in the gelatin solution can also be 10%, 11%, 12%, 13%, 15%, 17%, 18%, 19%, 21%, 22%, 23%, 24%, 25%, 26%, 27%, 28%, 29% or 30%.

[0054] The present application drops O / W emulsion into a forming liquid for cross-linking and curing, forms a calcium alginate gel layer on the outside as a wall material, transfers the formed blast bead to a chitosan solution, forms a uniform chitosan coating on the surface of the calcium alginate gel by virtue of the electrostatic interaction between calcium alginate and chitosan. Subsequently, it is further transferred to a rubber solution prepared from gelatin and tannic acid, and a tannic acid and gelatin film layer is formed by virtue of the electrostatic adsorption principle, which is tightly attached to the surface layer of the blast bead. The blast bead is not only provided with effective antibacterial performance, but also the dense rubber film layer significantly enhances the toughness and mechanical properties of the blast bead, and effectively prevents the evaporation of internal moisture. Finally, it is cooled in a dimethyl silicone oil cooling liquid, and after washing with purified water, a chrysanthemum blast bead with a particle size of (9.17±0.25) mm and an elasticity of (3±0.29) N is obtained. The elasticity of the blast bead is increased by 273% (p<0.001) relative to the unmodified blast bead, and is increased by 134% (p<0.05) relative to the chitosan-modified intermediate product, as shown in Figure 5 , and the particle size is increased due to the modification, as shown in Figure 4 .

[0055] Example 2

[0056] The present embodiment provides the application of the chrysanthemum blast bead prepared in Example 1 in a replaceable chrysanthemum blast bead constant-temperature eye mask. The replaceable chrysanthemum blast bead constant-temperature eye mask (as shown in Figure 3 ) comprises a replaceable blast bead bin, a plurality of chrysanthemum blast beads are placed in the replaceable blast bead bin, a PID temperature control element is arranged in the replaceable blast bead bin, a temperature display screen and a rotary switch are arranged on the outer surface of the replaceable blast bead bin, and a fixed elastic band is arranged between the two ends of the replaceable chrysanthemum blast bead constant-temperature eye mask.

[0057] The above is only a preferred embodiment of the present application, and does not limit the present application in any way. Any simple modification, change and equivalent change made on the basis of the technical essence of the present application to the above embodiment are still within the protection scope of the technical solution of the present application.

Claims

1. A method for preparing chrysanthemum popping beads, characterized in that, The preparation method comprises the following steps: S1, preparation of a molding liquid: sodium alginate powder is added to hydrogen-rich water to swell for a certain time, then stirred to a transparent gel, then glycerol and Span 20 are added, and after continuous stirring and dispersion, a molding liquid is obtained; S2, preparation of an aqueous phase: first, glycine, glycerol, calcium chloride and hydrogen-rich water b are mixed uniformly to obtain a mixed liquid; carboxymethyl cellulose sodium is dissolved in hydrogen-rich water a to obtain a mixed liquid a; the mixed liquid a is added to the mixed liquid and mixed uniformly to obtain an aqueous phase; S3, preparation of an oil phase: gum arabic, chrysanthemum essential oil and menthol are added to liquid paraffin, and mixed uniformly by grinding to obtain an oil phase; S4, preparation of a core material: the aqueous phase obtained in S2 is added to the oil phase obtained in S3, and then emulsified by a rapid grinding method to obtain an O / W emulsion; S5, preparation of a chitosan solution: chitosan is added to purified water, and then the pH value is adjusted, stirred to dissolve, and a chitosan solution is obtained; S6, preparation of a rubber skin liquid: gelatin and tannic acid are added to purified water, and heated in a water bath to dissolve the gelatin, then glycerol a is added and stirred uniformly to obtain a rubber skin liquid; the rubber skin liquid is stored at constant temperature for standby; S7, molding and curing of the burst beads: the O / W emulsion obtained in S4 is slowly dropped into the molding liquid obtained in S1 for cross-linking and curing to obtain burst bead embryos; the burst bead embryos are transferred to the chitosan solution obtained in S5 for soaking for a certain time, then soaked in the rubber skin liquid obtained in S6, and an initial product is obtained; the initial product is cooled in dimethyl silicone oil, then washed, and chrysanthemum burst beads are obtained.

2. The method for preparing chrysanthemum burst beads according to claim 1, characterized in that, The mass ratio of the sodium alginate powder, hydrogen-rich water, glycerol and Span 20 in S1 is 1:50:2.5:0.1, the mass fraction of the hydrogen-rich water is 90-98%, and the mass fraction of the glycerol is 1-10%; the swelling time is 2h, and the transparent gel is obtained by magnetic stirring at a speed of 800rpm; the continuous stirring and dispersion time is 5min. The mass ratio of the glycine, glycerol, calcium chloride and hydrogen-rich water b in S2 is 0.2:4:0.4:10; the mass ratio of the carboxymethyl cellulose sodium and the hydrogen-rich water a is 0.4:30; and the volume ratio of the mixed liquid a and the mixed liquid is 1:

3.

3. The method for preparing chrysanthemum burst beads according to claim 1, characterized in that, ​ 4. The method for preparing chrysanthemum burst beads according to claim 1, characterized in that, The mass ratio of the gum arabic, chrysanthemum essential oil, menthol and liquid paraffin in S3 is 20:1:1:60, the mass fraction of the chrysanthemum essential oil is 0.1-2%, the mass fraction of the menthol is 0.1-2%, the preparation method of the chrysanthemum essential oil is as follows: removing impurities and moldy parts from good quality chrysanthemum, crushing to a particle size of 40-60 mesh, then loading into an extraction kettle for extraction with supercritical CO2, then performing resolution to obtain an extract, and then performing separation by reduced pressure distillation to obtain the chrysanthemum essential oil; the extraction pressure is 25 MPa, the temperature is 45℃, the time is 3-5 h, the CO2 flow rate is set to 20 L / h, and anhydrous ethanol is used as the entraining agent; the resolution pressure is 5.5 MPa, the temperature is 40℃; the reduced pressure distillation temperature is 40-60℃, the time is 2-4 h, and the pressure is 0.05-0.1 MPa.

5. The method for preparing chrysanthemum burst beads according to claim 1, characterized in that, In S4, the volume ratio of the water phase to the oil phase is 1.2:1, and the emulsification time is 5 min.

6. The method for preparing chrysanthemum burst beads according to claim 1, characterized in that, In S5, the mass fraction of chitosan in the chitosan solution is 1-10%, the pH value is adjusted to 5-6 with acetic acid, the stirring is magnetic stirring at a rotation speed of 800 rpm, and the stirring time is 1 h.

7. The method for preparing chrysanthemum burst beads according to claim 1, characterized in that, In S6, the mass fraction of gelatin in the gelatin solution is 10-40%, the mass fraction of tannic acid in the gelatin solution is 0.1-1%, the mass fraction of glycerol a in the gelatin solution is 10-30%, the temperature of the constant temperature heating of the water bath is 70℃, and the gelatin solution is stored at a constant temperature of 70℃.

8. The method for preparing chrysanthemum burst beads according to claim 1, characterized in that, In S7, the volume ratio of the O / W emulsion, the forming liquid, the chitosan solution and the gelatin solution is 1:10:10:5; the O / W emulsion is slowly dropped into the forming liquid through a dropper at a rate of 2 s / drop; the crosslinking and solidification time is 1 h at a temperature of 25℃; the soaking time in the chitosan solution is 30 min at a temperature of 25℃; the continuous soaking time in the gelatin solution is 1 min at a temperature of 70℃; the cooling temperature is 25℃, and the cooling time is 30 min; and the washing uses purified water.

9. A chrysanthemum pop ball, characterized by, A chrysanthemum pearl is prepared by the preparation method of any one of claims 1-8.

10. The use of a replaceable daisy pearl in a daisy pearl constant temperature eye mask, characterized in that, The replaceable chrysanthemum pearl constant temperature eye mask comprises a replaceable pearl bin, a PID temperature control element arranged in the replaceable pearl bin, a temperature display screen and a rotary knob switch arranged on the outer surface of the replaceable pearl bin, and a fixed elastic band arranged between the two ends of the replaceable chrysanthemum pearl constant temperature eye mask.

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