A traditional Chinese medicine composition for treating androgenetic alopecia

Abstract

This invention provides a traditional Chinese medicine composition for treating androgenetic alopecia, formulated from the following raw materials in parts by weight: 1.5-3 parts of processed Polygonum multiflorum, 1.5-3 parts of Drynaria fortunei, 0.5-1.5 parts of Glycyrrhiza uralensis, 2.5-3 parts of raw Platycladus orientalis leaves, 2.5-3 parts of Salvia miltiorrhiza, 1.5-3 parts of Angelica sinensis, and 1-2 parts of Ligusticum chuanxiong. The above-mentioned traditional Chinese medicine composition is obtained by decocting and concentrating the herbs after soaking them in cold water for 20-30 minutes. This invention uses traditional Chinese medicinal materials that promote blood circulation, nourish blood and essence, and have anti-inflammatory and anti-allergic effects as raw materials. It has multiple effects, including improving blood circulation and nourishing hair follicles, thus curing hair loss from the root cause. The synergistic effect of the above-mentioned herbs not only nourishes hair but also prevents hair loss and moisturizes the skin.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine composition technology, specifically relating to a traditional Chinese medicine composition for treating androgenetic alopecia. Background Technology

[0002] Androgenetic alopecia, also known as male pattern baldness, is mainly caused by genetic factors and the attack of hair follicles by dihydrotestosterone (DHT), leading to hair follicle miniaturization and hair cycle disorder.

[0003] Traditional Chinese medicine has been used in the treatment of androgenetic alopecia. For example, patent application number CN202411935165.8 discloses a traditional Chinese medicine active composition to improve the efficiency of hair loss prevention, comprising the following components: 8-10% Platycladus orientalis leaves, 1-3% Polygonum multiflorum, 1-3% ginseng, 13% Sophora flavescens, 1-3% Ligusticum chuanxiong, and 78-88% deionized water. However, this formula focuses on prevention, and the dosage and compatibility logic of the principal, assistant, adjuvant, and guide herbs fail to address both the symptoms and the root cause. While patent application number 202411261511.9 discloses a traditional Chinese medicine composition for preventing hair loss, comprising the following components by weight: 20-50 parts of processed Polygonum multiflorum, 20-50 parts of Platycladus orientalis leaves, 5-30 parts of Spirodela polyrhiza, 10-30 parts of Clematis chinensis, 10-30 parts of Ligusticum chuanxiong, 10-30 parts of Alisma plantago-aquatica, 10-35 parts of Lycium chinense root bark, 15-40 parts of Drynaria fortunei, 10-40 parts of Gleditsia sinensis, and 5-40 parts of Forsythia suspensa, this patent only verifies the external effects and does not demonstrate the therapeutic effect of the formula from the perspective of internal hormone levels and inflammation levels. Furthermore, Chinese patent application number CN202211050850.3 discloses a traditional Chinese medicine composition, its preparation method, and its application, specifically disclosing an application that can promote hair growth and assist in the treatment of hair loss. The aforementioned traditional Chinese medicine composition for treating hair loss is made from the following raw materials: 0.01-15 parts black sesame seeds, 2.5-100 parts Polygonum multiflorum vine, 2.5-100 parts Eclipta prostrata, 2.5-100 parts Platycladus orientalis leaves, 0.4-10 parts Lycopus lucidus, 2.5-100 parts Dioscorea hypoglauca, 1.5-60 parts Scutellaria baicalensis, 1.5-60 parts Phellodendron chinense, 1.5-50 parts Cinnamomum cassia, 0.75-30 parts Panax notoginseng, 0.75-30 parts Dalbergia odorifera, and 0.075-3 parts Styrax benzoin. However, the above composition still has some drawbacks, such as a large number of medicinal ingredients, complex formulation, cumbersome preparation process, difficulty in quality control, and challenges in clinical application. Furthermore, some of the medicinal materials are predominantly cold or warm in nature, and long-term use may burden the spleen and stomach, limiting the suitable population.

[0004] In summary, each combination of traditional Chinese medicine has its own advantages and disadvantages. The challenge in designing traditional Chinese medicine prescriptions lies in how to combine them rationally, avoid side effects and adverse reactions on the skin, and effectively treat androgenetic alopecia. Summary of the Invention

[0005] The purpose of this invention is to provide a traditional Chinese medicine compound to overcome the shortcomings of the rational combination and symptomatic treatment of androgenetic alopecia described in the background art.

[0006] To achieve the above objectives, the present invention adopts the following technical solution:

[0007] In a first aspect, the present invention provides a traditional Chinese medicine composition for treating androgenetic alopecia, which is formulated from the following raw materials in parts by weight: 1.5-3 parts of processed Polygonum multiflorum, 1.5-3 parts of Drynaria fortunei, 0.5-1.5 parts of Glycyrrhiza uralensis, 2.5-3 parts of raw Platycladus orientalis leaves, 2.5-3 parts of Salvia miltiorrhiza, 1.5-3 parts of Angelica sinensis, and 1-2 parts of Ligusticum chuanxiong.

[0008] Preferably, the traditional Chinese medicine composition is formulated from the following raw materials in parts by weight:

[0009] Prepared Polygonum multiflorum 2 parts, Drynaria fortunei 2 parts, Glycyrrhiza uralensis 1 part, raw Platycladus orientalis 3 parts, Salvia miltiorrhiza 3 parts, Angelica sinensis 2 parts, Ligusticum chuanxiong 1.5 parts.

[0010] Secondly, the present invention provides a method for preparing the above-mentioned traditional Chinese medicine composition, comprising the following steps:

[0011] After weighing the Chinese herbs according to the specified weight, soak them in cold water for 20-30 minutes, then decoct them at 110℃ and concentrate them to obtain the Chinese herbal composition.

[0012] Thirdly, the present invention provides the application of the above-mentioned traditional Chinese medicine composition in the preparation of a drug for treating androgenetic alopecia.

[0013] Fourthly, the present invention provides a pharmaceutical preparation for treating androgenetic alopecia, which is prepared using the above-mentioned traditional Chinese medicine composition.

[0014] The main pathogenesis of hair loss lies in the dysfunction of internal organs (especially the liver, kidneys, and spleen) and the imbalance of qi and blood. "Hair is the surplus of blood," meaning that deficiency of qi and blood prevents nourishment of the hair, leading to hair loss due to malnourishment of the hair roots. A constitution prone to blood heat and dryness easily damages yin blood, resulting in hair loss due to malnourishment of the hair roots. Therefore, the core idea of ​​this invention's compound herbal formula is: nourishing and invigorating blood, cooling blood and strengthening hair, and tonifying the liver and kidneys. First, Angelica sinensis is a holy medicine for nourishing and invigorating blood, aiming to directly replenish yin blood; hair is the surplus of blood, and sufficient blood nourishes the hair, while also improving blood circulation in the scalp to deliver nutrients to the hair follicles. Processed Polygonum multiflorum tonifies the "root of hair," the liver and kidneys, benefits essence and blood, blackens the hair, and consolidates the foundation for hair growth. These two herbs work together as the principal herbs, forming the core force for nourishing blood and benefiting essence. Salvia miltiorrhiza can invigorate blood, remove blood stasis, cool blood, and calm the mind, assisting Angelica sinensis in enhancing its blood-invigorating and stasis-removing effects, allowing the tonifying herbs to reach the hair roots smoothly. Chuanxiong (Ligusticum striatum) acts as a guiding herb, effectively promoting blood circulation, dispelling wind, and relieving pain. It directs the medicinal power directly to the scalp lesions, significantly improving local blood circulation. Gusuibu (Drynaria fortunei) invigorates blood, heals injuries, tonifies the kidneys, and strengthens bones. Its warm nature promotes blood circulation and hair follicle metabolism; it also enters the kidney meridian, warming and tonifying kidney yang. Together with He Shou Wu (Polygonum multiflorum), one warm and one neutral, they tonify kidney qi. Danshen (Salvia miltiorrhiza), Chuanxiong, and Gusuibu serve as assistant herbs, enhancing the overall efficacy. Sheng Cebaiye (Platycladus orientalis) cools the blood, stops bleeding, and promotes hair growth and darkening, making it a key adjuvant for treating hair loss (especially blood-heat type). Its cold nature clears blood heat, alleviating scalp oiliness, itching, and hair loss caused by blood heat and wind dryness. Gancao (Glycyrrhiza uralensis) invigorates qi, strengthens the middle jiao, and aids in the generation of qi and blood. Its heat-clearing and detoxifying effects help Cebaiye clear heat toxins while harmonizing the properties of the other herbs. Sheng Cebaiye and Gancao (Glycyrrhiza uralensis) serve as adjuvant herbs, coordinating the medicinal properties. In summary, this traditional Chinese medicine compound can effectively treat hair loss, nourish hair follicles, and also has anti-inflammatory and anti-allergic effects. It can be used both internally and externally.

[0015] The uniqueness and approach of the prescription formulation provided by this invention lies in:

[0016] First, it combines blood-tonifying and blood-activating methods: Angelica sinensis and Polygonum multiflorum vigorously tonify blood, while Salvia miltiorrhiza and Ligusticum chuanxiong actively activate blood, embodying the principles of "treating wind by first treating blood, for when blood flows smoothly, wind will naturally subside" and "tonifying blood without causing stagnation." Sufficient and smooth blood flow ensures adequate nourishment for hair roots. Second, it addresses both the symptoms and the root cause: Raw Platycladus orientalis leaves clear heat and cool the blood, addressing the "evil qi" of blood heat that directly leads to hair loss, thus treating the symptoms; Polygonum multiflorum and Drynaria fortunei tonify the liver and kidneys, while Angelica sinensis tonifies blood, addressing the root cause by addressing the fundamental issues of liver, kidney, qi, and blood. Third, it combines ascending and guiding methods: Ligusticum chuanxiong acts as a "guiding herb," ​​ensuring the entire formula's power is concentrated on the head. Fourth, it combines cold and warm properties: The formula contains both cold Platycladus orientalis leaves and Salvia miltiorrhiza, as well as warming Ligusticum chuanxiong and Drynaria fortunei, with licorice harmonizing the balance, making the entire formula mild and neither too cold nor too hot, suitable for long-term treatment.

[0017] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0018] The raw materials used in this invention are all derived from the Chinese Pharmacopoeia. The key focus is on using traditional Chinese medicinal herbs that promote blood circulation, nourish blood and essence, and have anti-inflammatory and anti-allergic properties. These herbs possess multiple effects, including improving blood circulation and nourishing hair follicles, thus treating hair loss from a fundamental perspective. The synergistic effect of these herbs not only nourishes hair but also prevents hair loss and moisturizes the skin. This formula is based on nourishing and promoting blood circulation, strengthening the liver and kidneys, and addressing the symptoms by clearing heat and cooling the blood. The core principle is to create a suitable internal environment (abundant Qi and blood, good circulation) and a suitable scalp environment (free from heat, stagnation, and wind) for hair growth through a multi-pronged approach of unblocking, clearing, and nourishing. Animal experiments have verified that its efficacy effectively overcomes the various defects described in the background art. The traditional Chinese medicine composition prepared by this invention can be directly applied to the scalp, effectively acting directly on the scalp to slow the progression of the disease and promote hair growth. Preparation and use are both very convenient. Attached Figure Description

[0019] Figure 1 Hair growth in mice from different experimental groups.

[0020] Figure 2 The levels of testosterone and estrogen in the serum of mice in different experimental groups were shown.

[0021] Figure 3 The expression levels of inflammatory factors in the dorsal tissues of mice in different experimental groups.

[0022] Figure 4 The expression levels of apoptosis-related factors in the dorsal tissues of mice in different experimental groups. Detailed Implementation

[0023] The present invention will be further described below with reference to the embodiments and accompanying drawings.

[0024] Example 1: Preparation of Traditional Chinese Medicine Composition

[0025] Weigh each Chinese herb according to the following weights: 280g of processed Polygonum multiflorum, 280g of dried Drynaria fortunei, 140g of licorice root slices, 420g of raw Platycladus orientalis leaves, 420g of Salvia miltiorrhiza, 280g of Angelica sinensis, and 210g of Ligusticum chuanxiong.

[0026] Place the prepared medicinal materials in a special decoction bag and tie the bag tightly. Place the decoction bag in a decoction pot and add an appropriate amount of cold water to soak the medicinal materials for 30 minutes. After soaking, cover the pot and decoct at 110°C. After decoction, the decoction machine mechanically squeezes the bag to improve the extraction rate of the medicinal liquid. Finally, heat and concentrate the mixed medicinal liquid to obtain the Chinese herbal composition, which will be used as the drug for subsequent Chinese herbal treatment.

[0027] Example 2: By establishing a mouse model of male baldness (AGA), the significant therapeutic effect of traditional Chinese medicine preparations was verified.

[0028] This embodiment used 45 male C57BL / 6 mice, which were divided into 5 groups of 9 mice each: healthy control group, model group, minoxidil treatment group, low-dose traditional Chinese medicine treatment group, and high-dose traditional Chinese medicine treatment group.

[0029] In the healthy control group, testosterone was dissolved by daily gavage with saline and application of saline to the skin on the back. In the model group, testosterone was applied and saline was administered daily. In the minoxidil treatment group, testosterone, minoxidil, and saline were applied and administered daily. In the low-dose traditional Chinese medicine treatment group, testosterone was applied and 0.1 mL of the traditional Chinese medicine composition was mixed with 0.1 mL of drinking water was administered daily. In the high-dose traditional Chinese medicine treatment group, testosterone was applied and 0.2 mL of the traditional Chinese medicine composition was administered daily. The mice were grouped and fed for 28 days.

[0030] After animal modeling and treatment, three mice were randomly selected from each group for back tissue sampling, eyeball removal for blood collection, and the mouse carcasses were properly disposed of.

[0031] The levels of testosterone and estrogen in the serum of mice in each group were measured.

[0032] The expression levels of inflammatory factors in the dorsal tissues of mice in each group were detected.

[0033] The expression levels of apoptosis-related factors in various mouse dorsal tissues were detected.

[0034] Experimental results:

[0035] like Figure 1 As shown, hair growth on the backs of mice in the model group was the slowest, while hair growth was the most significant in the minoxidil treatment group and the high-dose traditional Chinese medicine treatment group.

[0036] like Figure 2 As shown, the experimental results indicate that, compared with the AGA model group (DHT group), the DHT concentration in the serum of AGA mice was significantly reduced after treatment with traditional Chinese medicine (TCM), while the high-dose TCM treatment group showed the best therapeutic effect. Simultaneously, the E2 concentration in the serum of AGA mice was significantly increased after TCM treatment, with the high-dose TCM treatment group approaching the level of the healthy control group. Combined with the hair growth in each group, this suggests that the TCM compound treatment effectively alleviated hair loss in mice by regulating the balance of estrogen and androgen in their bodies.

[0037] like Figure 3 As shown, the concentrations of mRNA in the skin tissue and protein in the serum of inflammatory cytokines in the male pattern baldness mouse model group were significantly upregulated, and both showed a downward trend after minoxidil treatment and traditional Chinese medicine treatment, with the high-dose traditional Chinese medicine treatment group showing a significant therapeutic effect. In conclusion, this traditional Chinese medicine compound has a significant alleviating effect on inflammation caused by male pattern baldness in mice.

[0038] like Figure 4 As shown, compared with the AGA model group, after treatment with traditional Chinese medicine, the mRNA expression levels of Bax and caspase9 in the skin tissue of AGA mice were significantly downregulated, while the mRNA expression level of Bcl-2 was significantly upregulated, indicating that traditional Chinese medicine treatment significantly inhibited skin cell apoptosis, and the high-dose treatment group had the best treatment effect.

[0039] Based on all the above experimental results, it can be concluded that the traditional Chinese medicine compound in this invention has significant therapeutic effects in regulating the balance of estrogen and androgen, and in anti-inflammatory effects.

Claims

1. A traditional Chinese medicine composition for treating androgenetic alopecia, characterized in that, Made from the following parts by weight of active pharmaceutical ingredient: Prepared Polygonum multiflorum 1.5-3 parts, Drynaria fortunei 1.5-3 parts, Glycyrrhiza uralensis 0.5-1.5 parts, raw Platycladus orientalis leaves 2.5-3 parts, Salvia miltiorrhiza 2.5-3 parts, Angelica sinensis 1.5-3 parts, Ligusticum chuanxiong 1-2 parts.

2. The traditional Chinese medicine composition according to claim 1, characterized in that, Made from the following parts by weight of active pharmaceutical ingredient: Prepared Polygonum multiflorum 2 parts, Drynaria fortunei 2 parts, Glycyrrhiza uralensis 1 part, raw Platycladus orientalis 3 parts, Salvia miltiorrhiza 3 parts, Angelica sinensis 2 parts, Ligusticum chuanxiong 1.5 parts.

3. A method for preparing the traditional Chinese medicine composition as described in claim 1 or 2, characterized in that, The preparation method includes the following steps: Weigh out the Chinese herbs according to the specified weight, soak them in cold water, then decoct them at 110°C, and concentrate them to obtain the Chinese herbal composition.

4. The preparation method according to claim 3, characterized in that, The Chinese herbs are placed in a decoction bag for soaking and decoction. After decoction, the decoction bag is squeezed to improve the extraction rate of the medicinal liquid.

5. The preparation method according to claim 3, characterized in that, Soaking time in cold water is 20-30 minutes.

6. The use of the traditional Chinese medicine composition as described in claim 1 in the preparation of a drug for treating androgenetic alopecia.

7. A pharmaceutical preparation for treating androgenetic alopecia, characterized in that, It is prepared using the traditional Chinese medicine composition as described in claim 1 or 2.

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