Sterilizing high-stability defoaming agent and preparation method thereof

Abstract

The invention discloses a sterilizing high-stability defoaming agent and a preparation method thereof, and particularly relates to the technical field of high-stability defoaming agents. The invention relates to a sterilizing high-stability defoaming agent which is prepared from the following raw materials in parts by mass: 20-40 parts of carrier oil, 5-15 parts of an emulsifying agent, 0.5-5 parts of a thickening agent, 0.5-2 parts of an antibacterial agent, 3-10 parts of a dispersing agent and 20-30 parts of deionized water. The antibacterial agent with a specific structure is introduced into the defoaming agent, so that the growth of bacteria and microorganisms can be effectively inhibited, the defoaming agent is prevented from going bad and decaying, the service life of the defoaming agent is prolonged, and the quality problem and the production cost increase caused by microbial pollution are reduced.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of high-stability defoamers, and particularly relates to a bactericidal high-stability defoamer and a preparation method thereof. BACKGROUND

[0002] In today's industrial production and daily life, defoamers, as a kind of key additive, play an indispensable role. It is mainly used to inhibit and eliminate the foam in various liquid systems, prevent excessive foam from causing production efficiency to decline, product quality to be damaged, and resources to be wasted, and so on. However, the existing defoamers have many problems to be solved in practical application.

[0003] On the one hand, the stability of many defoamers is poor. Under the complex industrial environment and long-term storage conditions, the components of the defoamer are prone to stratification, precipitation or metamorphism, etc., so that the defoaming performance of the defoamer is greatly reduced. For example, in some high-temperature, strong acid and alkali or high shear force systems, the stability of the defoamer is difficult to maintain, and the defoaming effect cannot be sustained and effectively exerted, which brings many uncertainties to the production process. On the other hand, the bactericidal performance is also a big shortcoming of the existing defoamers. Most defoamers do not have good antibacterial ability, and are prone to bacterial and microbial growth, which not only pollutes the production system and affects the product quality, but also causes the defoamer to deteriorate and corrupt, shortens its service life, and increases the production cost and quality control difficulty of enterprises. In addition, some defoamers also have the problems of poor compatibility with other components and poor dispersibility, which are difficult to uniformly disperse in the liquid system, affect the exertion of the defoaming effect, and even may cause adverse effects on the production system, such as equipment blockage, residue, etc.

[0004] Based on the problems of the existing defoamers in stability, bactericidal property and compatibility, a defoamer with bactericidal function and high stability and a preparation method thereof are developed to meet the urgent needs of high-quality defoamers in industrial production, improve production efficiency and product quality, reduce production cost and quality risk, and promote the healthy development of related industries. SUMMARY

[0005] The purpose of the present application is to solve the problems of poor stability and no good antibacterial ability in the prior art, and to provide a bactericidal high-stability defoamer with high stability and good bactericidal performance and a preparation method thereof.

[0006] To achieve the above-mentioned purpose, the technical scheme adopted by the present application is: a bactericidal high-stability defoamer, characterized by being made of the following mass parts of raw materials: carrier oil: 20-40 parts, emulsifier: 5-15 parts, thickening agent: 0.5-5 parts, antibacterial agent: 0.5-2 parts, dispersant: 3-10 parts, deionized water: 20-30 parts. The antibacterial agent is a compound shown in formula 1: Formula 1 In formula 1, R1 is a substituent, and specifically R1 is: methyl, methoxy, carboxyl, phenyl.

[0007] Preferably, the carrier oil is at least one of white mineral oil and vegetable oil.

[0008] Preferably, the emulsifier is at least one of dimethicone or Span 80.

[0009] Preferably, the thickening agent is fumed silica.

[0010] Preferably, the antibacterial agent is any one of the compounds shown in the following structures: ; .

[0011] Preferably, the dispersing agent is at least one of polyethylene glycol or polypropylene glycol.

[0012] A method for preparing a bactericidal high-stability defoaming agent, comprising the following steps: a. mixing and stirring the carrier oil and the thickening agent at 60-80°C for 1 hour to obtain a mixture A; b. adding the emulsifier and the dispersing agent to the mixture A, and shearing and dispersing at high speed for 30 minutes to obtain a mixture B; c. cooling the mixture B to 40°C, and then adding the antibacterial agent and deionized water, and continuing to stir for 20 minutes to obtain a mixture C; d. homogenizing the mixture C to obtain a bactericidal high-stability defoaming agent.

[0013] Preferably, in step b, a shearing emulsifier is used for shearing and dispersing, and the rotation speed is 8000-12000 rpm.

[0014] Preferably, in step d, a homogenizer is used for homogenization, and the homogenization pressure is 10-20 MPa.

[0015] Preferably, step d is carried out in a nitrogen atmosphere.

[0016] The antibacterial agent described in the present application has a heterocyclic ring and a polar group, which can achieve sterilization by destroying bacterial cell membrane integrity or interfering with metabolic enzyme activity. Groups such as carboxyl or phenyl can enhance interaction with bacterial surface proteins, leading to cell lysis; the heterocyclic structure may block bacterial DNA replication. The hydrophobic group in the molecule may be embedded in the bacterial cell membrane, interfering with the lipid bilayer structure, leading to leakage of cell contents. The heterocyclic structure may target key bacterial enzymes, blocking their biosynthetic pathways. In the defoaming agent system, the antibacterial agent cooperates with the carrier oil and emulsifier to ensure uniform dispersion of the molecule and prolong the persistence of the sterilization effect.

[0017] In the present application, the components collectively enhance stability through physical and chemical interactions. The carrier oil, thickening agent and emulsifier form a stable oil-water emulsion matrix to prevent delamination and precipitation. The antibacterial agent inhibits microbial growth and prevents deterioration; the dispersant ensures uniform dispersion of the components, reducing aggregation.

[0018] The carrier oil serves as the base medium, carrying other components, providing defoaming activity and preventing system delamination. In step a, it is mixed with the thickening agent at high temperature to form a uniform matrix, reducing precipitation. The thickening agent can increase the viscosity of the system, inhibit component precipitation and foam regeneration, and form a structured network in step a by mixing with the carrier oil at high temperature, strengthening the system strength and preventing delamination during storage. The emulsifier can reduce the oil-water interfacial tension, promote emulsification and ensure uniform distribution of components. By cooperating with the dispersant, a stable oil-in-water emulsion is formed through high-speed shearing to prevent phase separation. The antibacterial agent can inhibit the growth of bacteria and microorganisms, prevent the defoamer from deteriorating and prolong its service life. The specific structure of the antibacterial agent (heterocyclic ring and polar group) destroys the bacterial cell membrane or interferes with metabolic enzymes, and cooperates with the carrier oil and emulsifier to ensure uniform dispersion of the molecule. The dispersant promotes uniform dispersion of solid particles (such as thickening agents) and liquid components, improving compatibility, and in step b, it cooperates with the emulsifier to strengthen the high-speed shearing emulsification effect, ensuring stable suspension of the antibacterial agent and thickening agent, reducing aggregation or precipitation. Deionized water as a solvent or carrier adjusts the flowability of the system and assists in forming an oil-in-water structure.

[0019] Compared with the prior art, the present application has the following advantages: 1. Significant improvement in sterilization performance: By introducing an antibacterial agent with a specific structure into the defoamer, the growth of bacteria and microorganisms can be effectively inhibited, preventing the defoamer from deteriorating and prolonging its service life, reducing quality problems and increased production costs caused by microbial contamination.

[0020] 2. Greatly improved stability: The use of a special preparation process and component combination makes the defoamer exhibit better stability in complex industrial environments and long-term storage conditions, reducing delamination, precipitation or deterioration, ensuring the sustained effectiveness of the defoaming performance and reducing uncertainty in the production process.

[0021] 3. Compatibility and dispersion optimization: By selecting appropriate carrier oil, emulsifier, thickener and dispersant components, and through a fine preparation process, the defoamer can be better compatible with other system components, uniformly dispersed in the liquid system, and fully exert the defoaming effect, reducing the adverse effects on the production system, such as equipment blockage and residual problems. BRIEF DESCRIPTION OF DRAWINGS

[0022] Figure 1 For the antibacterial agent 1 of the present application 1 HNMR chart. DETAILED DESCRIPTION

[0023] The technical solutions of the present application will be described clearly and completely below in combination with the drawings in the present application. Obviously, the described embodiments are only a part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor fall within the scope of protection of the present application.

[0024] Synthesis Example 1 Synthesis of the antibacterial agent 1: ; First step: under nitrogen atmosphere, 20 g of raw material 1, 22.65 g of raw material 2 and 300 g of toluene solution were added into the reaction system, 21.57 g of sodium tert-butyl alcohol, 1.03 g of tris(dibenzylideneacetone) palladium and 1.14 g of tri-tert-butyl phosphine were added into the reaction system, stirred uniformly, heated to 120℃, refluxed for 12 h; after the reaction was completed, the temperature was slightly lowered, diatomite was used for filtration to remove the salt and catalyst, the filtrate was cooled to room temperature, washed with water for three times, the organic phase was reserved, then the water phase was extracted with ethyl acetate; the combined organic phase was dried with anhydrous magnesium sulfate, and the solvent was removed using a rotary evaporator; rotary evaporation, column chromatography, using a mixture of petroleum ether and ethyl acetate as eluent, 18.36 g of intermediate 1 was obtained. Mass spectrum MS+1=298.

[0025] Second step: under nitrogen atmosphere, 18.36 g of intermediate 1, 14.24 g of raw material 3, 25.44 g of anhydrous potassium carbonate, 2.13 g of tetrakis(triphenylphosphine)palladium and 300 g of toluene were added into the reaction system, heated to 95℃, refluxed for 10 h, the heating was turned off, cooled to room temperature, and left to stand for liquid separation, the water phase was extracted with ethyl acetate twice, the combined organic phase was dried with anhydrous magnesium sulfate, filtered, rotary evaporated, and subjected to silica gel column chromatography, using a mixture of petroleum ether and ethyl acetate as eluent, rotary evaporation, 17.15 g of intermediate 2 was obtained. Mass spectrum MS+1=386.

[0026] Third step: under nitrogen atmosphere, 17.15 g of intermediate 2, 8.41 g of raw material 4 and 250 g of toluene solution were added into the reaction system, 8.55 g of sodium tert-butoxide, 0.4 g of tris (dibenzylideneacetone) dipalladium and 0.45 g of tri-tert-butyl phosphine were added into the reaction system, stirred uniformly, heated to 120℃, refluxed for 12 h; after the reaction was completed, the temperature was slightly lowered, diatomite was used for filtration to remove the salt and catalyst, the filtrate was cooled to room temperature, washed with water for three times, the organic phase was reserved, then the water phase was extracted with ethyl acetate; the combined organic phase was dried with anhydrous magnesium sulfate, and the solvent was removed using a rotary evaporator; rotary evaporation, column chromatography, using petroleum ether and ethyl acetate mixture as eluent, 15.99 g of antibacterial agent 1 was obtained. Mass spectrum MS+1=494.

[0027] Synthesis examples 2-4 Antibacterial agents 2-4 were synthesized in synthesis examples 2-4 in turn, referring to the synthesis method of synthesis example 1, replacing raw material 1 therein, and the rest being the same as synthesis example 1. The structure of raw material 1, the structure of antibacterial agents 2-4 and the mass spectrum MS+1 data are shown in Table 1.

[0028] Table 1. Structure of raw material 1, structure of antibacterial agents 2-4 and mass spectrum MS+1 data.

[0029]

[0030] Example 1 Preparation of a bactericidal and highly stable defoaming agent 1. Raw materials: Carrier oil: 30 parts, selected from white mineral oil; Emulsifier: 10 parts, selected from Span 80; Thickening agent: 3 parts, selected from fumed silica; Antibacterial agent: 1 part, selected from antibacterial agent 1 synthesized in synthesis example 1; Dispersant: 8 parts, selected from polyethylene glycol, Deionized water: 26 parts; 2. Preparation method: a. The carrier oil (30 parts of white mineral oil) and the thickening agent (3 parts of fumed silica) were added into the reaction kettle, heated to 70℃, mixed and stirred at a stirring speed of 500 rpm for 1 hour to obtain a uniform mixture A; b. The emulsifier (10 parts of Span 80) and the dispersant (8 parts of polyethylene glycol) were added into the mixture A, and a high-speed shearing emulsifier was used to perform high-speed shearing dispersion at 10000 rpm for 30 minutes to obtain a uniformly emulsified mixture B; c. The mixture B is cooled to 40℃, the antimicrobial agent (1 part of antimicrobial agent 1) and deionized water (26 parts) are added, and stirred at a stirring speed of 500 rpm for 20 minutes to obtain mixture C; d. The mixture C is transferred to a homogenizer, and homogenized under a nitrogen atmosphere at a pressure of 15 MPa for 10 minutes to obtain a bactericidal and highly stable defoaming agent.

[0031] Examples 2-4 A bactericidal and highly stable defoaming agent is prepared according to the preparation method of Example 1, wherein the antimicrobial agent is replaced by antimicrobial agents 2-4 synthesized in Synthetic Examples 2-4, respectively, and the rest remains the same as Example 1.

[0032] Comparative Example 1 A bactericidal and highly stable defoaming agent is prepared according to the preparation method of Example 1, wherein the antimicrobial agent is replaced by Comparative Compound 1, and the rest remains the same as Example 1. Comparative Compound 1: .

[0033] Comparative Example 2 A bactericidal and highly stable defoaming agent is prepared according to the preparation method of Example 1, wherein the antimicrobial agent is replaced by Comparative Compound 2, and the rest remains the same as Example 1. Comparative Compound 2: .

[0034] Comparative Example 3 A bactericidal and highly stable defoaming agent is prepared according to the preparation method of Example 1, wherein the antimicrobial agent is not added, and the rest remains the same as Example 1.

[0035] Comparative Example 4 A bactericidal and highly stable defoaming agent is prepared according to the preparation method of Example 1, wherein the mass fraction of the carrier oil is changed to 10 parts, and the rest remains the same as Example 1. Performance Test: 1. Defoaming performance test: The defoaming rate and bubble suppression rate of the bactericidal and highly stable defoaming agent prepared in the examples and comparative examples are tested according to GB / T 21885-2008, and the data are shown in Table 2.

[0036] 2. Antimicrobial performance test: The antimicrobial performance of the bactericidal and highly stable defoaming agent prepared in the examples and comparative examples is tested according to GB / T 21866-2008, and the data are shown in Table 2.

[0037] 3. Stability test: the antifoam agent with bactericidal high stability prepared in the example and the comparative example was placed in a 40℃ constant temperature box for 48 hours, and the performance decay rate (comparing the initial antifoam rate) of the antifoam agent was tested, and the data are shown in Table 2.

[0038] Table 2. Performance test results of the antifoam agent with bactericidal high stability prepared in the example and the comparative example.

[0039]

[0040] The data show that the antifoam agent in the example has overall higher antifoam rate, foam inhibition rate and bacteriostasis rate, and lower performance decay rate, higher stability, and shows good comprehensive performance. The antifoam agent in the comparative example has relatively lower antifoam rate, foam inhibition rate and bacteriostasis rate, higher performance decay rate, and lower stability. It is proved that the present application can significantly improve the bacteriostasis effect and stability of the antifoam agent by adding specific antibacterial agent and optimizing the formula, and at the same time, better antifoam performance is achieved.

[0041] Although the embodiments of the present application have been shown and described, it can be understood by those skilled in the art that various changes, modifications, replacements and variations can be made to the embodiments without departing from the principles and spirits of the present application, and the scope of the present application is defined by the appended claims and their equivalents.

Claims

1. A bactericidal high-stability defoaming agent, characterized by, It is made of the following raw materials by mass fraction: carrier oil: 20-40 parts, emulsifier: 5-15 parts, thickening agent: 0.5-5 parts, antibacterial agent: 0.5-2 parts, dispersing agent: 3-10 parts, deionized water: 20-30 parts; The antibacterial agent is a compound shown in formula 1: Formula 1; In formula 1, R1 is a substituent group, and specifically R1 is: methyl, methoxy, carboxyl, phenyl.

2. The high-stability antiseptic defoamer according to claim 1, characterized in that, The carrier oil is at least one of white mineral oil and vegetable oil.

3. The high-stability antiseptic defoamer according to claim 1, characterized in that, The emulsifier is at least one of polydimethylsiloxane or Span 80.

4. The high-stability antifoaming agent according to claim 1, characterized by, The thickening agent is fumed silica.

5. The high-stability antifoaming agent according to claim 1, characterized by comprising: The antibacterial agent is any one of the compounds shown in the following structure: ； 。 6. The high-stability antifoaming agent according to claim 1, characterized by, The dispersing agent is at least one of polyethylene glycol or polypropylene glycol.

7. A process for the preparation of a bactericidal, highly stable antifoam agent according to any one of claims 1 to 6, characterized in that It comprises the following steps: a. Mix and stir the carrier oil and thickening agent at 60-80 DEG C for 1 hour to obtain mixture A; b. Add the emulsifier and dispersing agent to the mixture A, and shear disperse at high speed for 30 minutes to obtain mixture B; c. After the mixture B is cooled to 40 DEG C, add the antibacterial agent and deionized water, and continue to stir for 20 minutes to obtain mixture C; d. Homogenize the mixture C to obtain a bactericidal high-stability defoaming agent.

8. The method of claim 7, wherein the method is characterized by, In step b, a shear emulsifier is used for shearing dispersion, and the rotation speed is 8000-12000 rpm.

9. The method of claim 7, wherein the method is characterized by, In step d, a homogenizer is used for homogenization, and the homogenization pressure is 10-20 MPa.

10. The method of claim 7, wherein the method is characterized by, Step d is carried out in a nitrogen atmosphere.

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