Efficient mixing device for pharmaceutic adjuvants

Abstract

The invention discloses an efficient mixing device for pharmaceutic adjuvants, and belongs to the technical field of material stirring. Comprising a mixing cylinder, supporting leg bases arranged on the four sides of the bottom of the mixing cylinder, a mounting bottom frame arranged at the bottoms of the supporting leg bases, a heating coil arranged in an inner hollow layer of the mixing cylinder, a lower discharging pipe arranged at the bottom of the mixing cylinder in a communicating mode and a discharging pipe connected with the lower end of the lower discharging pipe, and a rotor shaft of a motor penetrates through a top cover and is connected with a rotating pipe. A connecting head is connected to the bottom of the rotating pipe, and an outer supporting and stirring frame and an inner supporting and stirring frame are mounted on the two sides of the connecting head; the inner wall of the inner cylinder of the mixing cylinder is provided with a top position sealing mechanism, the top position sealing mechanism is used for controlling and adjusting the upper space of the pharmaceutic adjuvants, and a top gas suction mechanism is arranged on the rotary pipe; a liquid level discharge control mechanism is mounted on the top plugging mechanism; and an air pressure sensor and a liquid level meter are respectively arranged on the top plugging mechanism. According to the invention, full-time vacuumizing operation is not needed, and part of micromolecular active ingredients and water generated by reaction between feed liquid are retained in the stirring process, so that the quality of the auxiliary material product is guaranteed.

Description

TECHNICAL FIELD

[0001] The application belongs to the technical field of material mixing, and particularly relates to a high-efficiency mixing device for medicinal excipients. BACKGROUND

[0002] A medicinal excipient is a substance contained in a medicinal preparation except for an active ingredient. In addition to excipient, serving as a carrier and improving stability, the medicinal excipient has important functions such as solubilization, solubilization aid, controlled release, etc., and the use and preparation quality of the medicinal excipient affect the quality, safety and effectiveness of the medicinal product.

[0003] In the production process of part of liquid medicinal excipients, different solid raw materials are mixed with pure water to prepare liquid, and then stored in different pressurized tanks for standby. When production is needed, the liquid in the different pressurized tanks is added to the mixing tank according to the proportion and stirred to prepare the liquid medicinal excipient. In this production mode, the process of mixing the solid raw materials with the pure water in a certain amount is concentrated in the off-season, the liquid can be stored in a large sterile pressurized tank, and the mixing of the liquid is more rapid and uniform, the production efficiency is high, and it is particularly suitable for supplying excipients for medicines in urgent need of large quantities; secondly, compared with the traditional production mode, the mixing and preparation of the liquid medicinal excipient can effectively avoid the situation that the inner wall of the mixing tank is solidified, the period for cleaning the inner wall of the mixing tank can be prolonged, thereby further providing conditions for high-efficiency production of liquid medicinal excipients.

[0004] When the liquid in the pressurized tank is quantitatively discharged into the mixing tank by the quantitative discharge pump, the gas in the mixing tank is entrained and the material of the liquid is affected, a large amount of bubbles will be generated in the process of mixing and stirring the liquid, and compared with the bubbles generated by stirring the pure water, the liquid mixture has a smaller surface tension than the bubbles, and the bubbles are more persistent after formation.

[0005] As known, in the production of excipients, the bubbles generated by stirring will hinder the mixing and mass transfer process of the reaction materials, and affect the mixing and reaction efficiency of the effective components in the liquid. Therefore, in addition to controlling the stirring speed, the mixing tank needs to be subjected to full-time vacuum pumping during stirring. In this way, the gas entrained in the liquid during mixing can be discharged, thereby effectively reducing the amount of bubbles generated during stirring.

[0006] However, this full-time vacuum pumping operation tests the inner layer material of the mixing tank, especially some small molecular effective components and water generated by the reaction between the liquids are quickly taken out, which has a certain influence on the quality of the excipient product. SUMMARY

[0007] The purpose of the present application is to provide a high-efficiency mixing device for medicinal excipients to solve the problems in the prior art.

[0008] In order to achieve the above object, the present application provides the following technical scheme: the pharmaceutical excipient high-efficiency mixing device comprises a mixing cylinder, support leg seats arranged at the four sides of the bottom of the mixing cylinder, a mounting chassis arranged at the bottom of the support leg seat, a heating coil arranged in the empty layer of the mixing cylinder, a lower discharge pipe communicated with the bottom of the mixing cylinder and a discharge pipe connected with the lower end of the lower discharge pipe, a plug discharge mechanism is arranged in the discharge pipe, and the plug discharge mechanism is used for plugging the bottom of the mixing cylinder and discharging the mixed pharmaceutical excipient in the mixing cylinder;

[0009] An ultrasonic vibrator is mounted on the inner side wall of the inner layer of the mixing cylinder, a top cover is arranged at the top of the mixing cylinder, a top cover is mounted on the top of the top cover, a motor is mounted on the top of the top cover, the rotor shaft of the motor penetrates through the top cover and is connected with a spiral pipe, a connecting head is connected with the bottom of the spiral pipe, outer and inner support stirring frames are mounted on the two sides of the connecting head;

[0010] A top sealing plug mechanism is mounted on the inner wall of the inner cylinder of the mixing cylinder, the top sealing plug mechanism is used for controlling and adjusting the upper space of the pharmaceutical excipient, a top gas suction mechanism is arranged on the spiral pipe, and the top gas suction mechanism is used for suction of the space between the upper liquid level of the pharmaceutical excipient in the mixing cylinder and the top sealing plug mechanism;

[0011] A liquid level control discharge mechanism is mounted on the top sealing plug mechanism, the liquid level control discharge mechanism is used for controlled discharge of the raw materials into the inner cylinder of the mixing cylinder, a gas pressure sensor and a liquid level meter are arranged on the top sealing plug mechanism respectively, the gas pressure sensor is used for gas-liquid pressure between the upper liquid level of the pharmaceutical excipient in the mixing cylinder and the top sealing plug mechanism, and the liquid level meter is used for detecting the liquid level height of the pharmaceutical excipient in the mixing cylinder;

[0012] A control mechanism is mounted on one side of the mixing cylinder, the control mechanism is used for analyzing the real-time input liquid level signal of the liquid level meter and the real-time input gas pressure signal of the gas pressure sensor, controlling the lifting height of the top sealing plug mechanism, the suction action of the top gas suction mechanism and the discharge and stop operation of the liquid level control discharge mechanism, and calculating the stirring time to control the operation of the plug discharge mechanism.

[0013] Compared with the prior art, the present application has the following beneficial effects:

[0014] The medicinal auxiliary material high-efficiency mixing device in the application, after the liquid level control and discharge mechanism controls the batch addition of the liquid, the top gas suction mechanism sucks away the gas in the upper part of the liquid in the mixing cylinder, cooperates with the ultrasonic vibrator operation to cause the ultrasonic vibration of the liquid, the gas originally carried in the liquid is also effectively sucked away, and then the vacuum state is formed, and then the top sealing mechanism moves down to isolate the liquid in the space with only the liquid, when stirring, the bubbles in the liquid can be effectively avoided, and under such setting, the vacuum operation is not needed in the whole period, and in the stirring process, part of the small molecule effective components and water generated by the reaction between the liquids are reserved, so that the quality of the auxiliary material product is guaranteed.

[0015] The medicinal auxiliary material high-efficiency mixing device in the application, under the auxiliary control of the control mechanism, the top gas suction mechanism, the top sealing mechanism and the liquid level control and discharge mechanism alternately and orderly operate according to the set instructions, the degree of automation is high, and the use is convenient. BRIEF DESCRIPTION OF DRAWINGS

[0016] Figure 1 It is a front view schematic diagram of the application;

[0017] Figure 2 It is a front view schematic diagram of the application; Figure 1

[0018] Figure 3 It is an enlarged structure schematic diagram of the discharge cylinder connection of the application;

[0019] Figure 4 It is an enlarged structure schematic diagram of the discharge cylinder of the application; Figure 2

[0020] Figure 5 It is an enlarged structure schematic diagram of a of the application; Figure 2

[0021] Figure 6 It is an enlarged structure schematic diagram of b of the application; Figure 2

[0022] Figure 7 It is an enlarged structure schematic diagram of c of the application; Figure 2

[0023] Figure 8 It is an enlarged structure schematic diagram of the control mechanism of the application; Figure 2

[0024] It is an enlarged structure schematic diagram of the control mechanism of the application; Figure 9

[0025] ​​​​​​In the figure: 1 mixing cylinder, 2 support leg seat, 3 pipe, 4 lower pipe, 5 support plate, 6 electric telescopic rod, 7 connecting plate, 8 cylinder, 9 sealing ring, 10 material guide hole, 11 heating coil, 12 ultrasonic vibrator, 13 top cover, 14 top cover, 15 motor, 16 rotary pipe, 17 connecting head, 18 outer stirring frame, 19 inner stirring frame, 20 suction hole, 21 sealing bearing, 22 cover, 23 pipe, 24 pump, 25 sealing plate, 26 sealing ring, 27 sealing ring, 28 sealing ring, 29 convex ring, 30 force screw, 31 locking nut, 32 outer sealing ring, 33 discharge port, 34 electromagnetic valve, 35 telescopic pipe, 36 inlet pipe, 37 electric telescopic rod, 38 air pressure sensor, 39 liquid level meter, 40 temperature sensor, 41 inner support plate, 42 plug, 43 soft sleeve, 44 connecting rod, 45 air hole, 46 support connecting rod, 47 movable sealing ring, 48 inner support plate, 49 support plate, 50 spring, 51 fixed rod, 52 control box, 53 development board, 54 integrated relay, 55 driver group, 56 industrial computer, 101 mounting chassis, 701 movable opening. DETAILED DESCRIPTION

[0026] The technical solutions in the embodiments of the application will be clearly and completely described below with reference to the drawings in the embodiments of the application.

[0027] Referring to Figure 1 and Figure 2 The pharmaceutical excipient high-efficiency mixing device comprises a mixing cylinder 1, support leg seats 2 fixed by bolts on the four sides of the bottom of the mixing cylinder 1, a mounting chassis 101 welded on the bottom of the support leg seats 2, a heating coil 11 welded in the inner space of the mixing cylinder 1, a lower pipe 4 arranged at the bottom of the mixing cylinder 1, and a pipe 3 connected to the lower end flange of the lower pipe 4, and a plug discharge mechanism arranged in the pipe 3, which is used to block the bottom of the mixing cylinder 1 and discharge the mixed pharmaceutical excipient in the mixing cylinder 1.

[0028] The power connection end of the heating coil 11 is connected to the power output end of the temperature controller through a cable, the main power input end of the temperature controller is connected to an external power source through a cable, and the heating coil 11 is 2 cm away from the outer layer of the mixing cylinder 1.

[0029] The other end of the pipe 3 is connected to an industrial suction pump, and the industrial suction pump is used to suck the product tank on the filling line.

[0030] When the plug discharge mechanism operates, the pharmaceutical excipient stirred into a product can be effectively discharged; and when the plug discharge mechanism is disconnected, the inner bottom of the mixing cylinder 1 is flattened, so that part of the liquid cannot be effectively mixed and stirred.

[0031] The ultrasonic vibrator 12 is fixed to the inner side wall of the inner layer of the mixing cylinder 1 by bolts, and the power supply line of the ultrasonic vibrator 12 is connected to the electric signal output end of the ultrasonic generator by a cable; the top cover 13 is arranged on the top of the mixing cylinder 1, the outer edge of the top of the mixing cylinder 1 and the lower end of the outer edge of the top cover 13 are both provided with a sealing ring groove, a rubber ring is tightly pressed in the sealing ring groove, and the mixing cylinder 1 and the top cover 13 are uniformly locked in the circumferential direction by bolts; the top cover 13 is integrally provided with a top cover 14 on the top, the motor 15 is fixed to the top cover 14 by bolts at the center position of the top of the top cover 14, the motor 15 is a servo motor, the rotor shaft of the motor 15 penetrates through the top cover 14 and is flange-connected to the rotary pipe 16, the bottom flange of the rotary pipe 16 is flange-connected to the connecting head 17, and the connecting head 17 is fixed to the outer stirring frame 18 and the inner stirring frame 19 by bolts on both sides;

[0032] The top cover 14 is also provided with an air filter net on one side, so that the inside and outside of the top cover 14 can flow with air, and conditions are provided for the upward movement of the pressure sealing plate 25 without obstruction.

[0033] It is worth noting that when the stirring is not performed, the rotation angle of the motor 15 is controlled by the servo motor controller to meet the condition that the outer stirring frame 18 is located at the front and the inner stirring frame 19 is located at the rear, which does not affect the sensing of the liquid level by the liquid level meter 39.

[0034] The operation of the motor 15 drives the rotary pipe 16 to rotate, thereby driving the outer stirring frame 18 and the inner stirring frame 19 to rotate, so that the liquid in the mixing cylinder 1 can be fully stirred. The ultrasonic vibrator 12 is selected to be 40KHZ, and when it is operated, it can cause high-frequency vibration of the liquid in the mixing cylinder 1, thereby accelerating the fragmentation of the gas bubbles, improving the flow of the gas, and accelerating the floating of the gas, thereby providing conditions for the top gas suction mechanism to remove the gas in the liquid.

[0035] The inner wall of the inner cylinder of the mixing cylinder is provided with a top sealing plug mechanism, the top sealing plug mechanism is used for controlling and adjusting the upper space of the medicinal materials, the top gas suction mechanism is arranged on the rotary pipe 16, and the top gas suction mechanism is used for sucking the gas in the space between the upper liquid level of the medicinal materials in the mixing cylinder 1 and the top sealing plug mechanism;

[0036] The top gas suction mechanism first sucks the vacuum in the area of the mixing cylinder 1 which is not filled with liquid, and after completion, the top sealing plug mechanism continuously lowers the area which is not filled with liquid until it is attached to the liquid surface, so that the vacuum in the mixing cylinder 1 does not need to be maintained for a long time, and the gas mixed into the liquid can also be effectively avoided.

[0037] The liquid level control and discharge mechanism is arranged on the top sealing plug mechanism, and the liquid level control and discharge mechanism is used for discharging the raw materials into the inner cylinder of the mixing cylinder 1 in a controlled amount; the gas pressure sensor 38 and the liquid level meter 39 are arranged on the top sealing plug mechanism respectively, and the liquid level meter 39 is a radar liquid level meter; the gas pressure sensor 38 is used for detecting the gas-liquid pressure between the upper liquid level of the medicinal materials in the mixing cylinder 1 and the top sealing plug mechanism, and the liquid level meter 39 is used for detecting the liquid level height of the medicinal materials in the mixing cylinder 1;

[0038] The right side of the mixing cylinder 1 is provided with a control mechanism for analyzing the real-time input liquid level signal of the liquid level gauge 39 and the real-time input air pressure signal of the air pressure sensor 38, and controlling the lifting height of the top sealing plug mechanism, the suction action of the top air suction mechanism and the discharge stop operation of the liquid level control discharge mechanism, and calculating the stirring time to control the operation of the plug discharge mechanism.

[0039] Under the action of the control mechanism, the top sealing plug mechanism and the top air suction mechanism automatically perform the top air suction and discharge and the lowering of the space.

[0040] Referring to Figure 1 , Figure 2 , Figure 3 and Figure 4 , the plug discharge mechanism includes a support plate 5 bolted to the upper right side of the discharge pipe 3, an electric telescopic rod 1 6 bolted to the support plate 5, the electric telescopic rod 1 6 being a step motor driven electric telescopic rod, a top rod of the electric telescopic rod 1 6 being bolted to a connecting plate 7, a discharge cylinder 8 being slidably arranged in the lower discharge pipe 4, the discharge cylinder 8 being a cylindrical structure with an open lower end and a closed upper end, the discharge cylinder 8 being provided with annular grooves on the upper and lower sides of the outer side, and a sealing ring 9 being adhered and sealed in the annular grooves by resin, the sealing ring 9 being a rubber soft ring, and the outer wall of the rubber soft ring being closed and pressed against the inner wall of the lower discharge pipe 4, the upper part of the discharge cylinder 8 being uniformly provided with guide holes 10 in a ring shape, the inner diameter of the guide holes 10 being 10 cm; the middle right side of the lower discharge pipe 4 being provided with a movable opening 701, the connecting plate 7 penetrating through the movable opening 701 and being bolted to the right side of the discharge cylinder 8.

[0041] When the top rod of the electric telescopic rod 1 6 is extended, the discharge cylinder 8 is lifted up, and the guide holes 10 are exposed to the inside of the mixing cylinder 1, so that the liquid material stirred in the mixing cylinder 1 can be discharged; when the top rod of the electric telescopic rod 1 6 is retracted, the discharge cylinder 8 is lowered to the top surface being flush with the bottom layer in the mixing cylinder 1, which can effectively prevent the material liquid from entering the discharge pipe 3 and ensure that the lower material liquid is fully stirred.

[0042] Referring to Figure 2 , Figure 5 and Figure 7 , the top air suction mechanism includes suction holes 20 uniformly arranged on the upper part of the spiral pipe 16 in a ring shape, sealing bearings 21 being sealingly and interference fitted on the upper and lower parts of the spiral pipe 16, outer rings of the sealing bearings 21 being sealingly and interference fitted with cover shells 22, the left side of the cover shells 22 being integrally provided with a connecting discharge pipe 23, the left end of the connecting discharge pipe 23 penetrating through the left side of the top cover 14 and being flange connected to the suction end of a suction and discharge pump 24.

[0043] With such a configuration, the suction and discharge pump 24 can perform vacuum suction on the non-material space in the mixing cylinder 1 through the spiral pipe 16 without affecting the rotation of the spiral pipe 16 driven by the motor 15.

[0044] The top gas suction mechanism further comprises an inner support plate I 41 integrally arranged on the inner wall of the coil pipe 16, the inner support plate I 41 is provided with a plug hole which is a tapered circular hole with a wide upper part and a narrow lower part, the plug hole is tightly pressed with a pressing plug 42 which is a circular cone structure with a wide upper part and a narrow lower part, the pressing plug 42 is tightly sleeved with a soft sleeve 43 which is made of rubber, the lower end of the soft sleeve 43 is integrally provided with a connecting rod 44, the middle part of the coil pipe 16 is uniformly provided with gas suction holes 45 in a ring shape, the upper part of the connecting rod 44 is uniformly welded with a support connecting rod 46 in a ring shape, the outer side of the support connecting rod 46 is fixedly provided with a movable sealing ring 47 through screws, the movable sealing ring 47 is a circular ring structure, the movable sealing ring 47 seals the ports of the gas suction holes 45, the inner wall of the coil pipe 16 and the lower part of the gas suction holes 45 are seamlessly welded with an inner support plate II 48, one end of the connecting rod 44 is slidably penetrated through the inner support plate II 48 and is fixedly provided with a support plate 49 through bolts, the connecting rod 44 is sleeved with a spring 50 and the two ends of the spring 50 are respectively supported on the inner support plate II 48 and the support plate 49.

[0045] And a gas connection pipe is further arranged on one side of the mixing cylinder 1, and one end of the gas connection pipe is connected with the helium pressurized tank through an electromagnetic valve, when the pressure sealing plate 25 covers the gas suction holes 45, the port of the gas connection pipe on one side of the mixing cylinder 1 is sealed, when the electromagnetic valve is opened, the helium in the helium pressurized tank will quickly enter the mixing cylinder 1, thereby providing conditions for the work of discharging the stirred liquid.

[0046] The spring 50 is a compression and rebound type, the initial compression and rebound force of the spring 50 is 20 Newton, through the elastic support force of the spring 50, the movable sealing ring 47 is kept sealed, and the soft sleeve 43 is tightly sealed in the inner wall of the plug hole, thereby effectively ensuring that the gas in the mixing cylinder 1 enters the coil pipe 16; when the suction pump 24 is operated, the pressing plug 42 and the movable sealing ring 47 are driven to move upward under the action of suction force, thereby extracting the gas from the mixing cylinder 1 through the gas suction holes 45.

[0047] It is worth noting that in the actual operation process, the control liquid level of the liquid needs to be at a position 3mm below the lower side of the gas suction holes 45.

[0048] Referring to Figure 2 and Figure 6 , the top sealing plug mechanism comprises a pressure sealing plate 25 slidably arranged in the mixing cylinder 1, the sealing installation hole is provided with a sealing support ring I 26, a sealing support ring II 27 and a pressure sealing ring 28 from bottom to top, the material of the sealing support ring I 26 is neoprene, the material of the sealing support ring II 27 is silica gel, the bottom of the pressure sealing ring 28 is integrally provided with a pressure convex ring 29, the coil pipe 16 is tightly attached by the sealing support ring I 26 and the sealing support ring II 27, and is slidably fitted with the pressure sealing ring 28, the outer edge of the pressure sealing plate 25 and the sealing installation hole is uniformly and circularly screwed with a bearing screw 30, one end of the bearing screw 30 penetrates through the pressure sealing ring 28 and is locked by a locking nut 31.

[0049] When the lock nut 31 locks the lock of the force screw 30, the embossing ring 29 is pressed into the sealing support ring 2, so that the sealing support ring 2 is pressed downward and expanded laterally, so that the sealing support ring 1 and the sealing support ring 2 seal and cover the outer edge of the rotary pipe 16. When the pressure sealing plate 25 moves up and down under the drive of the electric telescopic rod 2, gas cannot pass through the cooperation part of the rotary pipe 16 and the pressure sealing plate 25.

[0050] The outer edge of the pressure sealing plate 25 is vertically and uniformly provided with an outer ring groove, and the inner wall of the outer ring groove is adhered to the outer sealing ring 32 by resin glue. The material of the outer sealing ring 32 is rubber, and the outer sealing ring 32 is pressed and sealed in the inner wall of the inner layer of the mixing cylinder 1.

[0051] When the pressure sealing plate 25 moves up and down under the drive of the electric telescopic rod 2, gas cannot pass through the cooperation part of the pressure sealing plate 25 and the mixing cylinder 1.

[0052] Under the overall arrangement, the mixing cylinder 1 is effectively divided into a liquid mixing environment and a gas environment by the pressure sealing plate 25, and the two do not interfere with each other, so as to effectively avoid the gas being involved in the mixing and stirring process of the liquid.

[0053] The inner top right side of the top cover 14 is bolted to the electric telescopic rod 2, which is a step motor driven electric telescopic rod. The top rod of the electric telescopic rod 2 is fixed to the pressure sealing plate 25 by annular bolts.

[0054] Driven by the electric telescopic rod 2, the pressure sealing plate 25 can move up and down in the mixing cylinder 1 in a closed manner.

[0055] Referring to Figure 1 and Figure 2 , the liquid level control discharge mechanism includes a discharge port 33 arranged on the pressure sealing plate 25. The top of the discharge port 33 is flange-connected to an electromagnetic valve 34. The liquid inlet end of the electromagnetic valve 34 is flange-connected to the lower end of a telescopic pipe 35. The upper end of the telescopic pipe 35 is flange-connected to a through port arranged annularly on the top of the top cover 14. The upper end of the through port is flange-connected to a feeding pipe 36. The feeding pipe 36 is flange-connected to the liquid outlet end of an externally arranged quantitative pump. The liquid inlet end of a liquid defoaming machine is connected to the lower discharge end of an externally arranged pressurized tank through a pipeline.

[0056] It is worth noting that the electromagnetic valve 34 is first opened, and after completion, the quantitative pump is started. After the quantitative pump is operated by suction, the top pump is controlled to stop running, reaches the preset liquid level, and the electromagnetic valve 34 is closed.

[0057] Referring to Figure 2 , the bottom of the pressure sealing plate 25 is sealingly fixed with a temperature sensor 40, which is used to detect the temperature of the medicinal material.

[0058] Referring toFigure 1 、 Figure 2 and Figure 8 The control mechanism includes a fixed rod 51 bolted to the right side of the mixing cylinder 1, the right end of the fixed rod 51 is bolted to a control box 52, the upper part of the control box 52 is bolted to a development board 53 using an insulating pad, the lower part of the control box 52 is provided with an integrated relay 54 and a driver group 55, and the panel of the control box 52 is provided with an industrial computer 56.

[0059] The controlled end of the power supply of the motor 15 is connected to the power control end of an external servo controller through a cable, the main power supply of the external servo controller is connected to an external power supply through a cable; the controlled end of the power supply of the electric telescopic rod one 6 is connected to the power control end of one of the drivers in the driver group 55 through a cable, the controlled end of the power supply of the electric telescopic rod two 37 is connected to the power control end of another driver in the driver group 55 through a cable, the main power input end of each driver in the driver group is connected to an external power supply through a cable, and the power connection end of the pump 24, the potential connection end of the electromagnetic valve 34 and the power control connection end of the ultrasonic generator are connected to the connection end of the integrated relay 54 through a cable, and the power input end of the integrated relay is connected to an external power supply through a cable; the main power connection end of the industrial computer 56 is connected to an external power supply through a cable.

[0060] In addition, the connection end of the integrated relay 54 is also connected to the control connection end of the electromagnetic valve through a cable.

[0061] Referring to Figure 9 The development board 53 includes a temperature signal receiving module, an air pressure signal receiving module, a liquid level signal receiving module and a relay signal receiving module, the transmission line of the temperature sensor 40 is connected to the signal input pin of the temperature signal receiving module, the temperature signal receiving module is used to receive the temperature signal input by the temperature sensor 40 in real time; the signal line of the air pressure sensor 38 is connected to the signal input pin of the air pressure signal receiving module, the air pressure signal receiving module is used to receive the air pressure signal input by the air pressure sensor 38 in real time; the signal line of the liquid level meter is connected to the signal input pin of the liquid level signal receiving module, the liquid level signal receiving module is used to receive the liquid level signal input by the liquid level meter 39 in real time; the shared connection end of the ultrasonic generator is connected to the signal connection pin of the relay signal receiving module through a transmission line, and the relay signal receiving module is used to receive the process signal of the ultrasonic generator in real time.

[0062] The temperature signal receiving module, the air pressure signal receiving module, the liquid level signal receiving module and the relay signal receiving module are connected to a signal analysis module, the signal analysis module is connected to a temperature control signal output module, a relay signal control output module one, a relay signal control output module two, a relay signal control output module three, a steering speed control output module, a steering number control output module one and a steering number control output module two.

[0063] The signal analysis module processes the real-time received temperature signal into temperature data, and compares the processed temperature data with the set temperature action threshold value, and issues a temperature control instruction to the temperature control signal output module according to the comparison result;

[0064] The signal output pin of the temperature control signal output module is connected to the control signal input end of the temperature controller through a signal line, the set temperature action threshold value is W, when the pressure sealing plate 25 moves to the set position, and the temperature sensing end of the temperature sensor 40 is inserted into the liquid, the actual measured temperature value is R, when R > W, the temperature control signal output module issues a stop heating instruction to the temperature controller, when R = W, the temperature control signal output module issues a constant temperature control instruction to the temperature controller, and when R < W, the temperature control signal output module issues a continuous heating instruction to the temperature controller.

[0065] The signal analysis module processes the real-time acquired air pressure signal and liquid level signal into air pressure data and liquid level data, and analyzes the processed air pressure data and liquid level data in combination with the set standard liquid level data, the action liquid level data and the action air pressure data, respectively, and issues a control air suction mechanism suction instruction to the second relay control output module, a top sealing mechanism lifting instruction to the first relay control output module, and a liquid level control and drainage mechanism on-off instruction to the third relay control output module, after the control air suction mechanism, the top sealing mechanism and the liquid level control and drainage mechanism instructions are executed, a motor 15 running instruction is issued to the first relay control output module to time the motor 15 running time, and when the preset stirring time is reached, a plug and drain mechanism lifting operation instruction is issued to the second relay control output module;

[0066] The standard liquid level data U includes U1, U2, U3, U4,..., Un, wherein U1 is the liquid level data after the first liquid is added according to the calibration amount, U2 is the liquid level data after the second liquid is added according to the calibration amount, and so on to the last liquid level data Un, the signal output pin of the third relay control output module is connected to the control signal input end of the micro control unit of each quantitative pump through a signal line, when the signal analysis module receives the external quantitative feeding instruction, the electromagnetic valve 34 is opened according to the feeding sequence, and a running instruction is issued to the micro control unit of the quantitative pump according to the feeding sequence, and each time a standard liquid level data is reached, the corresponding electromagnetic valve 34 is closed by the third relay control output module, and the next electromagnetic valve 34 is opened and closed after a delay of 8 seconds, until the last electromagnetic valve 34 is closed from the open state, and the liquid feeding program is completed;

[0067] The action air pressure data L needs to meet: when the pressure sealing plate 25 does not act and vacuum is extracted, the space above the liquid in the mixing cylinder 1 is extracted to 0.08 MPa;

[0068] The full position liquid level data P needs to meet: the electric telescopic rod 37 drives the pressure sealing plate 25 to move downwards until the lower surface of the pressure sealing plate 25 contacts with the liquid surface in the mixing cylinder 1;

[0069] In addition, the signal analysis module also stores empty tank liquid level data K, which is the liquid level data obtained when the liquid in the mixing cylinder 1 is effectively discharged when the pressure sealing plate 25 is reset.

[0070] The rotation speed control module controls the rotation speed of the motor 15 to be 1500 r / min.

[0071] The operation mode is: after the liquid level control discharge mechanism is operated according to the operation mode, all the electromagnetic valves 34 are closed, the relay control module II is instructed to operate the gas suction mechanism, the discharge pump 24 operates until the gas pressure value input by the gas pressure sensor 38 is L, the relay control module II is instructed to stop operating the gas suction mechanism, the discharge pump 24 stops operating and the one-way valve at the port thereof is closed; after a delay of 5 seconds, the full position sealing mechanism is instructed to extend, the electric telescopic rod 37 drives the pressure sealing plate 25 to move downwards until the real-time input liquid level data reaches P, the full position sealing mechanism is instructed to stop operating, and the electric telescopic rod 37 stops moving; after a delay of 3 seconds, the rotation speed control module is instructed to control the motor 15 to operate, the operation time of the motor 15 is counted, and when the preset stirring time is reached, the rotation speed control module is instructed to reset the motor 15; after a delay of 5 seconds, the full position sealing mechanism is instructed to retract and reset, the electric telescopic rod 37 drives the pressure sealing plate 25 to move upwards and reset; after a delay of 1 second, the relay signal control module II is instructed to control the electromagnetic gas valve to open, and helium enters the upper space of the mixing cylinder 1; after a delay of 2 seconds, the rotation number control module II is instructed to control the sealing and discharging mechanism to open, the electric telescopic rod 6 extends, drives the discharge cylinder 8 to move upwards, the guide hole 10 moves upwards into the mixing cylinder 1, the stirred liquid is discharged into the discharge cylinder 8 through the guide hole 10, and is discharged into the discharge pipe 3, and under the action of the industrial discharge pump, the stirred liquid is sucked into the finished product tank on the filling line; when the liquid level data input by the liquid level meter 39 returns to K, the relay signal control module II is instructed to control the electromagnetic gas valve to close, and the rotation number control module II is instructed to control the sealing and discharging mechanism to close, and the electric telescopic rod 6 retracts and resets, and the discharge cylinder 8 retracts into the lower discharge pipe 4.

[0072] When the liquid level control discharge mechanism is initially operated, the signal analysis module instructs the relay signal control module to operate the ultrasonic generator, and after the sealing and discharging mechanism is operated, the signal analysis module instructs the relay signal control module to stop operating the ultrasonic generator;

[0073] The signal analysis module is bidirectionally connected with the signal processing module, and the signal processing module is bidirectionally connected with the mapping processing module.

[0074] In this way, the processing process of the signal analysis module can be dynamically viewed through the industrial computer 56, and the industrial computer 56 can also be used to issue operation instructions to the signal analysis module and input corresponding preset parameters into the signal analysis module.

[0075] The working principle of the embodiment is as follows:

[0076] The ultrasonic vibrator 12, the liquid level control discharge mechanism, the top sealing mechanism and the top gas suction mechanism: after the batch of liquid is added by the liquid level control discharge mechanism, the gas above the liquid in the mixing cylinder 1 is sucked away by the top gas suction mechanism, and the ultrasonic vibration caused by the operation of the ultrasonic vibrator 12 causes the liquid to vibrate, and the gas originally contained in the liquid is also effectively sucked away, thereby forming a vacuum state, and then the top sealing mechanism moves down to isolate the liquid in the space containing only the liquid, so that the bubbles in the liquid can be effectively avoided during stirring, and in this way, the vacuum operation is not required all the time, and during the stirring process, part of the small molecules of effective components and water generated by the reaction between the liquids are reserved, thereby ensuring the quality of the auxiliary material product.

[0077] The temperature sensor 40, the control mechanism: the temperature value of the liquid obtained by the temperature sensor 40 is used as a comparison parameter to control the heating of the liquid by the heating coil 11 according to the comparison with the action temperature threshold value; the gas pressure signal and the liquid level signal obtained by the gas pressure sensor 38 and the liquid level meter 39 are used as comparison parameters to control the top gas suction mechanism, the top sealing mechanism and the liquid level control discharge mechanism to alternately and orderly operate according to the set instructions, thereby achieving high automation and convenient use.

[0078] The above only describes the preferred embodiment of the present application, and is not used to limit the protection scope of the present application.

Claims

1. A high-efficiency mixing device for pharmaceutical excipients, comprising a mixing cylinder (1), support leg seats (2) arranged on the four sides of the bottom of the mixing cylinder (1), a mounting chassis (101) arranged at the bottom of the support leg seats (2), heating coils (11) arranged in the inner empty layer of the mixing cylinder (1), a lower discharge pipe (4) communicated with the bottom of the mixing cylinder (1), and a discharge pipe (3) connected to the lower end of the lower discharge pipe (4), characterized in that: The drain pipe (3) is provided with a plugging mechanism, which is used to block the bottom of the mixing cylinder (1) and discharge the mixed pharmaceutical excipients in the mixing cylinder (1); An ultrasonic transducer (12) is installed on the inner side wall of the mixing cylinder (1). A top cover (13) is provided on the top of the mixing cylinder (1). A top cover (14) is installed on the top of the top cover (13). A motor (15) is installed on the top of the top cover (14). The rotor shaft of the motor (15) passes through the top cover (14) and is connected to a spiral tube (16). A connector (17) is connected to the bottom of the spiral tube (16). An outer stirring frame (18) and an inner stirring frame (19) are installed on both sides of the connector (17). The inner wall of the mixing cylinder is equipped with a top sealing mechanism, which is used to control and adjust the upper space of the pharmaceutical excipients. The spiral tube (16) is equipped with a top air suction mechanism, which is used to evacuate the space between the liquid level of the pharmaceutical excipients in the mixing cylinder (1) and the top sealing mechanism. The top sealing mechanism is equipped with a liquid level control and discharge mechanism, which is used to control the amount of raw materials discharged into the inner cylinder of the mixing cylinder (1); the top sealing mechanism is respectively equipped with a pressure sensor (38) and a level gauge (39). The pressure sensor (38) is used to measure the gas-liquid pressure between the liquid level of the pharmaceutical excipients in the mixing cylinder (1) and the top sealing mechanism, and the level gauge (39) is used to detect the liquid level height of the pharmaceutical excipients in the mixing cylinder (1); A control mechanism is installed on one side of the mixing cylinder (1). The control mechanism is used to analyze the real-time liquid level signal input by the liquid level gauge (39) and the real-time air pressure signal input by the air pressure sensor (38), and to control the lifting and lowering height of the top sealing mechanism, the suction action of the top air suction mechanism, and the discharge and stop operation of the liquid level control and discharge mechanism. The operation of the plug discharge mechanism is controlled by calculating the stirring time.

2. The pharmaceutical material high-efficiency mixing device according to claim 1, characterized in that: The plugging mechanism includes a support plate (5) on one side of the upper part of the drain pipe (3), an electric telescopic rod (6) is provided on the support plate (5), the top rod of the electric telescopic rod (6) is connected to a connecting plate (7), a drain cylinder (8) is slidably provided inside the lower drain pipe (4), a sealing ring (9) is provided on the upper and lower parts of the outer side of the drain cylinder (8), a guide hole (10) is uniformly provided in the upper circumference of the drain cylinder (8), a movable opening (701) is provided on one side of the middle part of the lower drain pipe (4), and the connecting plate (7) passes through the movable opening (701) and is connected to one side of the drain cylinder (8).

3. The pharmaceutical material high-efficiency mixing device according to claim 2, characterized in that: The top air suction mechanism includes suction holes (20) evenly arranged in a circumferential direction on the upper part of the spiral tube (16). Sealed bearings (21) are provided on the spiral tube (16) at both the upper and lower parts of the suction holes (20). A cover (22) is provided on the sealed bearing (21). A drain pipe (23) is provided on one side of the cover (22). One end of the drain pipe (23) is connected to a suction pump (24). The top gas suction mechanism further comprises an inner support plate one (41) arranged on the inner wall of the rotary pipe (16), the inner support plate one (41) is internally provided with a plug hole, the plug hole is tightly provided with a compression plug (42), the compression plug (42) is provided with a soft sleeve (43), the lower end of the soft sleeve (43) is connected with a connecting rod (44), the middle part of the rotary pipe (16) is uniformly provided with gas suction holes (45) in a ring shape, the upper part of the connecting rod (44) is uniformly provided with support connecting rods (46) in a ring shape, the outer side of the support connecting rods (46) is provided with movable sealing rings (47), the movable sealing rings (47) seal the ports of the gas suction holes (45), the inner part of the rotary pipe (16) and the lower part of the gas suction holes (45) are provided with an inner support plate two (48), one end of the connecting rod (44) penetrates the inner support plate two (48) and is provided with a support sheet (49), the connecting rod (44) is sleeved with a spring (50), and the two ends of the spring (50) are respectively supported on the inner support plate two (48) and the support sheet (49).

4. The pharmaceutical material high-efficiency mixing device according to claim 3, characterized in that: The top sealing mechanism comprises a compression sealing plate (25) slidingly arranged in the mixing cylinder (1), the sealing mounting hole is provided with a sealing support ring one (26), a sealing support ring two (27) and a compression sealing ring (28) from bottom to top, the bottom of the compression sealing ring (28) is provided with a compression convex ring (29), the rotary pipe (16) penetrates the sealing support ring one (26), the sealing support ring two (27) and the compression sealing ring (28), the outer edge of the compression sealing plate (25) is uniformly connected with force bearing screws (30) in a ring shape, one end of the force bearing screws (30) penetrates the compression sealing ring (28) and is locked by a locking nut (31), the outer edge of the compression sealing plate (25) is vertically and uniformly provided with outer sealing rings (32), and the outer sealing rings (32) are compressed in the inner layer of the inner wall of the mixing cylinder (1). The inner top of the top cover (14) is provided with an electric telescopic rod two (37), and the top rod of the electric telescopic rod two (37) is connected to the compression sealing plate (25).

5. The pharmaceutical material high-efficiency mixing device according to claim 4, characterized in that: The liquid level control discharge mechanism comprises a discharge port (33) arranged on the compression sealing plate (25), the top of the discharge port (33) is connected with a solenoid valve (34), the liquid inlet end of the solenoid valve (34) is connected with a telescopic pipe (35), the upper end of the telescopic pipe (35) is connected to the through port arranged in a ring shape on the top of the top cover (14), and one end of the through port is connected with an inlet pipe (36) outside the pressurized tank.

6. The pharmaceutical excipient high efficiency mixing device of claim 5, wherein: The bottom of the compression sealing plate (25) is provided with a temperature sensor (40), and the temperature sensor (40) is used for detecting the temperature of the medicinal excipients.

7. The pharmaceutical excipient high efficiency mixing apparatus of any one of claims 1-6, wherein: The control mechanism comprises a fixed rod (51) connected to one side of the mixing cylinder (1), one end of the fixed rod (51) is connected with a control box (52), the upper part of the control box (52) is provided with a development board (53), the control box (52) and the lower part of the development board (53) are respectively provided with an integrated relay (54) and a driver group (55), and the panel of the control box (52) is provided with an industrial computer (56).

8. The pharmaceutical material high-efficiency mixing device according to claim 7, characterized in that: The development board (53) includes a temperature signal receiving module, an air pressure signal receiving module, a liquid level signal receiving module, and a relay signal receiving module. The temperature signal receiving module is used to receive the temperature signal input by the temperature sensor (40) in real time. The air pressure signal receiving module is used to receive the air pressure signal input by the air pressure sensor (38) in real time. The liquid level signal receiving module is used to receive the liquid level signal input by the liquid level meter (39) in real time. The relay signal receiving module is used to receive the process signal of the ultrasonic wave generator in real time. The temperature signal receiving module, the air pressure signal receiving module, the liquid level signal receiving module, and the relay signal receiving module are connected to a signal analysis module. The signal analysis module is connected to a temperature control signal output module, a relay signal control output module one, a relay signal control output module two, a relay signal control output module three, a steering rotation speed control output module, a steering rotation number control output module one, and a steering rotation number control output module two. The signal analysis module processes the temperature signal received in real time into temperature data, compares the processed temperature data with the set temperature action threshold, and issues a temperature control instruction to the temperature control signal output module based on the comparison result. The signal analysis module processes the air pressure signal and the liquid level signal obtained in real time into air pressure data and liquid level data, respectively, and analyzes the processed air pressure data and liquid level data in combination with the set standard liquid level data, the set liquid level data, and the set action air pressure data. The signal analysis module issues a control suction instruction to the relay control output module two to control the top air suction mechanism, a top position sealing mechanism lifting instruction to the steering rotation number control output module one, a control liquid level control and discharge mechanism on-off instruction to the relay control output module three, and a motor (15) operation instruction to the steering rotation speed control output module after the operation of the top air suction mechanism, the top position sealing mechanism, and the liquid level control and discharge mechanism is completed. The motor (15) operation time is timed, and a control plug discharge mechanism lifting operation instruction is issued to the steering rotation number control output module two when the preset stirring time is reached. When the liquid level control and discharge mechanism is initially operated, the signal analysis module issues an ultrasonic wave generator operation instruction to the relay signal control output module one, and issues an ultrasonic wave generator stop operation instruction to the relay signal control output module one after the plug discharge mechanism lifting operation instruction is completed. The signal analysis module is bidirectionally connected to a signal processing module, and the signal processing module is bidirectionally connected to a mapping processing module. The signal processing module batches the processing process information of the signal analysis module to the mapping processing module, and the mapping processing module constructs the processing process information to the signal receiving unit of the industrial computer (56) in real time. The preset parameters programmed in the industrial computer (56) are programmed in the preset storage area of the signal analysis module by the signal processing module.

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