Adjustable test tube rack for gene detection

Abstract

The invention belongs to the technical field of gene detection, and particularly relates to an adjustable test tube rack for gene detection, which comprises a base, a protective plate, a middle rack and an upper rack, and test tubes are arranged on the inner side of the base. The test tubes are stored through a limiting structure built by the middle rack and the upper rack, after the test tubes are placed on the base, the cover plate is turned over through supporting of the connecting rods and the swing arms, and the cover plate is located at the tops of the test tubes to cover the test tubes. When more test tubes are temporarily stored, the cover plate is turned over, the cover plate needs to be lifted upwards firstly during turning over, the swing arm moves upwards under the limitation of the first sliding rail on the inner side of the fixing frame, and then the cover plate is turned over. After the cover plate is turned over, the cover plate slides down from the interior of the through hole under the action of gravity and is suspended at the bottom of the cover plate under the support provided by the limiting rod, at the moment, the sealing cover and the limiting rod form a new test tube storage area, and when a test tube is inserted into the new test tube storage area, vibration of the piezoelectric ceramic can be amplified through the resonance plate, so that the content of the test tube obtains an active shaking effect; the reaction is uniform and stable.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of gene detection, in particular to a adjustable test tube rack for gene detection. BACKGROUND

[0002] As the core carrier equipment of molecular diagnostic laboratories, the gene detection test tube rack bears the key hub function in the biological sample processing flow. Its core mission is to replace manual intervention with precise automation, providing a standardized reaction environment for various biological samples (including whole blood, serum, formalin-fixed paraffin-embedded tissue, bronchoalveolar lavage fluid, etc.) and detection reagents, ensuring the standardization of the whole process from sample pretreatment to final detection.

[0003] The prior art has the following disadvantages: The gene detection test tube rack widely used in current laboratories has a serious risk of open pollution. Its basic framework adopts a 2-3 layer horizontal arrangement of injection molded ABS plastic supports, which form a fixed structure through 5 cm high vertical baffles on both sides. Although the 12-15 mm through-hole array CNC processed in the middle of the support is suitable for standard centrifuge tubes, it completely lacks a sealing protection mechanism. This design is particularly dangerous in a biological safety cabinet operating environment - when storing unsealed PCR tubes, 0.3-5 μm bioaerosols (including DNA / RNA fragments) carried by the circulating airflow can directly settle in the tube opening and penetrate through the 0.5 mm assembly gap between the support and the baffle. Laboratory test data shows that this open structure can increase the cross-contamination rate of valuable samples (such as puncture biopsy extract) by 12-15% during the temporary storage stage, directly leading to an abnormal increase in chimera mutation rate in NGS sequencing, seriously affecting the reliability of somatic mutation detection. Tumor samples worth tens of thousands of yuan are therefore at risk of secondary contamination during the pretreatment stage, which is in sharp contradiction with the closed-loop management standards required by modern molecular diagnostic laboratories. SUMMARY

[0004] In view of the deficiencies of the prior art, the present application provides a adjustable test tube rack for gene detection, which solves the problem of simple structure that cannot provide protection for the top of the test tube.

[0005] To achieve the above purpose, the present application provides the following technical solution: A adjustable test tube rack for gene detection, comprising a base, a guard plate, and a middle rack and an upper rack, a test tube is arranged on the inner side of the base, a cover is arranged above the upper rack, and the cover provides shielding for the top of the test tube stored therein when covering above the upper rack.

[0006] A cover plate is arranged on the outer side of the cover, a plurality of groups of through holes are formed in the inner side of the cover plate, and the cover is filled into the through holes as a shielding structure.

[0007] The side end of the cover plate is provided with a positioning block through bolt assembly, the inner side of the guard plate is provided with a fixing frame, the fixing frame and the positioning block are respectively provided with a swing arm and a connecting rod in rotation, and the cover plate realizes overturning action through the swing arm and the connecting rod.

[0008] In some embodiments, the swing arm is in "S" shape structure, the one side end of which is inserted into the fixing frame, and the other side end is connected with the connecting rod through the shaft body, so that stable rotation support is provided.

[0009] In some embodiments, the connecting rod 15 is composed of two parallel plate structures and is clamped on both sides of the swing arm, and the clamping mode on both sides can improve the stability of overall rotation.

[0010] In some embodiments, the side end of the connecting rod is provided with a slide rail two, and the slide rail two can accommodate the embedding of the positioning block after the cover plate is overturned, so that the force arm is shortened, and the influence of the insertion of the test tube on the center of gravity is reduced.

[0011] In some embodiments, a linkage rod is inserted between the two connecting rods, and the linkage rod is used to enhance the correlation between the two connecting rods, so that the synchronization rate is higher when the two connecting rods rotate.

[0012] In some embodiments, slide rails one are formed on both sides of the fixing frame, and a columnar structure is arranged at the end of the swing arm and is inserted into the slide rails one, and the swing arm, the connecting rod and the cover plate can all be vertically moved upward through the longitudinal stroke provided by the slide rails one, so that the cover plate can be vertically moved upward and then overturned when the cover plate is removed.

[0013] In some embodiments, four limiting rods are arranged on the outer side of the cover to ensure the stability of the sliding stroke of the cover, and disc-shaped structures are arranged at the ends of the limiting rods to hook the cover plate when the cover plate is overturned, so that the cover is prevented from falling off.

[0014] In some embodiments, a piezoelectric ceramic is embedded in the middle of the cover plate, and the piezoelectric ceramic is used to provide vibration effect, and a silica gel pad is arranged around the piezoelectric ceramic to embed a resonance plate.

[0015] In some embodiments, a lithium battery is further arranged in the cover plate for power supply.

[0016] Compared with the prior art, the application provides a test tube rack with adjustable cover plate for gene detection.

[0017] The utility model provides a kind of adjustable test tube rack for gene detection, and the test tube is stored by the limiting structure of middle rack and upper layer rack, after test tube is placed on base, it is supported by connecting rod and swing arm to overturn cover plate, cover plate is located at the top of test tube and covers test tube. When temporary expansion storage capacity is needed, operator can manually perform cover plate overturning procedure. The procedure is divided into two steps: first, vertically pull up cover plate, swing arm is limited to slide rail one inside fixed frame at this time, and smoothly lifts along axial direction;Then, implement plane overturning, so that cover plate is rotated 180 ° to reverse position. After overturning is completed, cover plate is slid down along vertical rail by default through hole under the action of gravity, and finally suspended support is provided by limiting rod. At this time, cover and limiting rod jointly constitute secondary storage area, and new test tube can be vertically inserted into the space, to realize dynamic expansion of storage capacity. Cover and limiting rod at this time form new test tube storage area, and test tube is inserted into it, and active shaking effect can be obtained for the content of test tube by resonance plate amplifying vibration of piezoelectric ceramic, to ensure that reaction is uniform and stable;

[0018] The above settings and processes make the structure have the following beneficial effects:

[0019] 1. By adding a 180 ° flip cover plate structure above the test tube rack body, when temporary storage of unsealed test tubes is needed during the experiment, the operator can flip the cover plate to the horizontal closed state. It can achieve physical isolation protection (effectively block airborne particles, droplets and ultraviolet light and other pollution sources), and does not affect visual observation of the liquid state in the test tube.

[0020] 2. By integrating the top flip structure, it can be used as an extended test tube rack to place test tubes after flipping, thereby temporarily providing additional storage space, and providing active vibration function to the internal test tubes, which eliminates reaction dead angles and ensures reaction uniformity, thereby improving the accuracy of detection results. BRIEF DESCRIPTION OF DRAWINGS

[0021] Figure 1 It is a schematic diagram of the overall structure of the utility model;

[0022] Figure 2 It is a schematic diagram of the end surface of the connecting rod side of the utility model;

[0023] Figure 3 It is a schematic diagram of the installation position structure of the connecting rod and swing arm of the utility model;

[0024] Figure 4 It is a schematic diagram of the specific form of the swing arm and connecting rod and the opening position of the slide rail two;

[0025] Figure 5 It is a schematic diagram of the overall structure of the utility model after cover plate overturning;

[0026] Figure 6The schematic diagram of the state of the cover plate of the application bearing the test tube after the rear through hole;

[0027] Figure 7 The schematic diagram of the state of the cover plate of the application after being turned over, the bottom cover and the limiting rod.

[0028] In the figure: 1, base; 2, guard plate; 3, middle rack; 4, upper rack; 5, test tube; 6, cover plate; 7, piezoelectric ceramic; 8, resonance plate; 9, lithium battery; 10, cover; 11, limiting rod; 12, fixing frame; 13, sliding rail one; 14, swing arm; 15, connecting rod; 16, sliding rail two; 17, positioning block; 18, linkage rod; 19, through hole. DETAILED DESCRIPTION

[0029] The technical solutions in the embodiments of the application will be clearly and completely described below with reference to the drawings in the embodiments of the application. Obviously, the described embodiments are only part of the embodiments of the application, rather than all the embodiments of the application. Based on the embodiments in the application, all other embodiments obtained by those skilled in the art without creative work fall within the protection scope of the application.

[0030] In the description of the application, it should be noted that the terms "upper", "lower", "inner", "outer", "front end", "rear end", "two ends", "one end", "the other end" and the like indicate the orientation or positional relationship shown in the drawings, and are only for the convenience of describing the application and simplifying the description, and therefore cannot be understood as indicating or implying that the devices or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as limiting the application. In addition, the terms "first" and "second" are only for descriptive purposes and cannot be understood as indicating or implying relative importance.

[0031] In the description of the application, it should be noted that unless otherwise explicitly specified and limited, the terms "mounting", "provided with", "connection" and the like should be understood broadly, for example, "connection" can be fixed connection, can also be detachable connection, or integrally connected; can be mechanical connection, can also be electrical connection; can be directly connected, can also be indirectly connected through an intermediate medium, can be the communication inside two elements. For those skilled in the art, the specific meaning of the above terms in the application can be understood according to the specific circumstances.

[0032] Please refer to Figures 1-7 In the present embodiment: a test tube rack for gene detection, comprising a base 1, a guard plate 2, and a middle rack 3 and an upper rack 4, a test tube 5 is arranged inside the base 1, a cover 10 is arranged above the upper rack 4, when the cover 10 covers above the upper rack 4, it can provide shielding for the top of the test tube stored therein, so that the test tube 5 temporarily stored without the cover will not be contaminated by the external environment.

[0033] In order to control the plurality of covers 10 uniformly, a cover plate 6 is arranged outside the cover 10, a plurality of through holes 19 are arranged inside the cover plate 6, and the cover 10 is filled into the through hole 19 as a shielding structure.

[0034] The cover 10 adopts a circular plate structure, which can also be a square, triangular or any plate structure capable of providing shielding. It should be noted that the shape of the through hole 19 is consistent with the cover 10 at all times.

[0035] In order to provide flexible shielding for the cover 10 and to smoothly take out the test tube 5, a positioning block 17 is arranged at the side end of the cover plate 6 through bolt assembly, a fixed frame 12 is arranged inside the guard plate 2, and a swing arm 14 and a connecting rod 15 are respectively arranged between the fixed frame 12 and the positioning block 17 (as shown in Figure 3 ), thereby the cover plate 6 can realize the overturning action (the overall state after overturning is shown in Figure 5 ) through the swing arm 14 and the connecting rod 15, so that the cover plate 6 can be flexibly turned open and the test tube 5 can be quickly taken out.

[0036] The swing arm 14 has an "S" shape structure (as shown in Figure 4 ), which is inserted into the inside of the fixed frame 12 at one end of the fixed frame 12, and the other end is rotatably connected to the connecting rod 15 through a shaft body, thereby providing stable rotary support. The connecting rod 15 is composed of two parallel plate structures and is clamped on both sides of the swing arm 14 (as shown in Figure 4 ), and the clamping on both sides can improve the stability of the overall rotation.

[0037] A slide rail two 16 is arranged at the side end of the connecting rod 15, which can accommodate the embedding of the positioning block 17 after the cover plate 6 is overturned (as shown in Figure 5 ), which can shorten the force arm and reduce the impact of the insertion of the test tube 5 inside the cover plate 6 on the center of gravity, thereby further improving the overall stability.

[0038] A linkage rod 18 is inserted between the two connecting rods 15, which is used to enhance the correlation between the two connecting rods 15, so that the synchronization rate is higher when they rotate.

[0039] Since the top of the test tube 5 will be embedded inside the cover plate 6, directly overturning the cover plate 6 will hook the test tube 5 at the side end of the cover plate 6, causing the overturning process to be stuck. In order to prevent this phenomenon, a slide rail one 13 is arranged on both sides of the fixed frame 12 (as shown in Figure 4 ), and a columnar structure is arranged at the end of the swing arm 14 and inserted into the slide rail one 13 on both sides, and the swing arm 14, the connecting rod 15 and the cover plate 6 can all be vertically moved upward through the longitudinal stroke provided by the slide rail one 13, so that the cover plate 6 can be vertically moved upward before being overturned when being taken out, thereby avoiding the side edge from hooking the test tube 5, and improving the smoothness of the cover plate 6.

[0040] Four limiting rods 11 are installed on the outside of the cover 10 (e.g., Figure 7 (As shown) To ensure the stability of the sliding stroke of the cover 10, a disc-shaped structure is provided at the end of the limiting rod 11 to hook the cover 6 when it is flipped, preventing the cover 10 from falling off (as shown). Figure 7 (As shown in the status), in this way, the cap 10 has two effects, as detailed below:

[0041] When the cover plate 6 is placed over the top of the test tube 5, the cap 10 acts as a dustproof shield, which is embedded in and seals the through hole 19 to ensure that the top of the test tube 5 is not contaminated.

[0042] After the cover 6 is flipped open, the test tube 5 can be freely taken out or placed (e.g., Figure 5 As shown in the diagram, the cap 10 is flipped over and slides down from the through hole 19 under the action of gravity, and is suspended from the bottom of the cover plate 6 by the support provided by the limiting rod 11 (as shown in the diagram). Figure 7 As shown), at this time, the cap 10 and the limiting rod 11 form a new storage area for the test tube 5, and the test tube 5 is inserted into it. This can temporarily expand the number of test tubes 5 that can be stored (e.g., Figure 6 (As shown).

[0043] A piezoelectric ceramic 7 is embedded in the center of the cover plate 6 to provide vibration. A resonant plate 8 is embedded inside the cover plate 6 around the piezoelectric ceramic 7 using silicone pads. The resonant plate 8 amplifies the vibration generated by the piezoelectric ceramic 7. A lithium battery 9 is also installed inside the cover plate 6 to provide power. Thus, the cover plate 6 can vibrate regularly from the center outwards. When the cover plate 6 is flipped over to serve as an extended area for placing test tubes 5 (e.g....),... Figure 5 As shown, it can actively provide vibration to test tube 5, thereby eliminating reaction dead zones, ensuring reaction uniformity, and thus improving the accuracy of test results.

[0044] In the embodiment, the storage of the test tubes 5 is achieved by the limiting structure jointly formed by the middle shelf 3 and the upper shelf 4, and the base 1 provides the bottom positioning support for the test tubes 5. After the test tubes 5 are placed on the base 1, the flipping action of the cover plate 6 is performed by the connecting rod 15 driving the swing arm 14, so that the cover plate 6 covers the top of the test tubes 5 to form a sealed barrier. When a plurality of test tubes 5 need to be temporarily stored, the flipping of the cover plate 6 needs to follow a specific operation procedure: first, the cover plate 6 is vertically pulled up, at this time, the swing arm 14 is lifted along the axial direction due to the limitation of the slide rail one 13 on the inner side of the fixed frame 12; then, the planar flipping of the cover plate 6 is performed. After the flipping is completed, the cover plate 6 slides along the vertical direction through the through hole 19 under the action of gravity, and finally is provided with the hanging support by the limiting rod 11. At this time, the cover 10 and the limiting rod 11 cooperatively form a new test tube 5 bearing area, and the test tube 5 can be vertically inserted into the space. The system simultaneously generates mechanical vibration by the piezoelectric ceramic 7, and amplifies the vibration energy by the resonant plate 8, so that the substances in the test tubes 5 obtain controlled oscillation, and the reaction system is ensured to maintain a uniform and stable mixing state.

[0045] Finally, it should be noted that: the above only describes the preferred embodiments of the present application, and is not used to limit the present application, although the foregoing embodiments of the present application are described in detail, for those skilled in the art, the technical solutions recorded in the foregoing embodiments can be modified, or some technical features can be replaced. Any modification, equivalent replacement, improvement, etc. within the spirit and principles of the present application shall be included in the protection scope of the present application.

Claims

1. A height-adjustable test tube rack for genetic testing, comprising a base (1), a cover (2), a middle shelf (3) and an upper shelf (4), test tubes (5) being arranged inside the base (1), characterized in that: The upper layer frame (4) is provided with a cover (10), which can provide shielding for the top of the test tube stored therein when covering the upper layer frame (4); The cover (10) is provided with a cover plate (6) outside, a plurality of through holes (19) are formed in the inner side of the cover plate (6), and the cover (10) is filled into the through holes (19) as a shielding structure; The side end of the cover plate (6) is provided with a positioning block (17) through bolt assembly, the inner side of the guard plate (2) is provided with a fixed frame (12), the fixed frame (12) and the positioning block (17) are respectively provided with a swing arm (14) and a connecting rod (15) rotatingly arranged therebetween, and the cover plate (6) realizes a turnover action through the swing arm (14) and the connecting rod (15).

2. The adjustable tube rack for genetic testing according to claim 1, wherein: The swing arm (14) is in an "S" shape structure, the one side end of which is inserted into the fixed frame (12), and the other side end is rotatably connected with the connecting rod (15) through a shaft body, thereby providing stable rotary support.

3. The adjustable tube rack for genetic testing according to claim 1, wherein: The connecting rod (15) is composed of two parallel plate structures and is clamped on both sides of the swing arm (14), and the overall rotation stability can be improved through the clamping mode on both sides.

4. The adjustable tube rack for genetic testing of claim 1, wherein: The side end of the connecting rod (15) is provided with a second sliding rail (16), which can accommodate the positioning block (17) embedded after the cover plate (6) is turned over, so as to shorten the force arm and reduce the influence of the test tube (5) inserted into the cover plate (6) on the center of gravity.

5. The adjustable tube rack for genetic testing according to claim 4, wherein: The two connecting rods (15) are inserted with a linkage rod (18) therebetween, which is used to enhance the correlation between the two connecting rods (15) and make the synchronous rate higher when they rotate.

6. The height-adjustable test tube rack for genetic testing according to claim 2, wherein: The two sides of the fixed frame (12) are provided with a first sliding rail (13), and the end of the swing arm (14) is provided with a columnar structure inserted into the two sides of the first sliding rail (13) and provided with a longitudinal stroke by the first sliding rail (13), so that the swing arm (14), the connecting rod (15) and the cover plate (6) can all be vertically moved upward, so that the cover plate (6) can be vertically moved upward before being turned over when being removed.

7. The adjustable tube rack for genetic testing according to claim 6, wherein: Four limiting rods (11) are arranged outside the cover (10) to ensure the stability of the sliding stroke of the cover (10), and the end of the limiting rod (11) is provided with a disc structure to hook the cover plate (6) when the cover plate (6) is turned over, preventing the cover (10) from falling off.

8. The height-adjustable test tube rack for genetic testing according to claim 1, wherein: A piezoelectric ceramic (7) is embedded in the middle of the cover plate (6), which is used to provide vibration effect, and a resonance plate (8) is embeddedly installed in the cover plate (6) around the piezoelectric ceramic (7) through the setting of silica gel pad.

9. The adjustable tube rack for genetic testing of claim 8, wherein: A lithium battery (9) for power supply is also arranged in the cover plate (6).

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