Sampling device for production of 5-fluorouracil intermediate

Abstract

The invention belongs to the technical field of medicine sampling devices, and relates to a sampling device for 5-fluorouracil intermediate production, the sampling device comprises a support frame, one end of the support frame is provided with a first adjusting motor, and a first screw rod in driving connection with the first adjusting motor is arranged between the two ends of the support frame. According to the sampling device disclosed by the invention, through the arrangement of the two groups of semicircular protective barrels, when the sampling barrel is used for sampling, the two groups of semicircular protective barrels automatically keep vertical angles with the sampling barrel, so that the interference of the semicircular protective barrels on sampling and introduced frictional resistance are avoided; the two groups of semicircular protective barrels can be close to each other in a vertical state to wrap the outer wall of the sampling barrel to form an outer-layer sealing barrier, so that when the sampling barrel leaks, the leakage and diffusion of a sample medium in the sampling barrel are quickly prevented, and the pollution to a workshop environment and the harm to the health of nearby personnel caused by continuous diffusion of the medium are reduced.

Description

TECHNICAL FIELD

[0001] The application belongs to the technical field of medicine sampling devices, and relates to a sampling device for 5-fluorouracil intermediate production. BACKGROUND

[0002] Fluorouracil is a pyrimidine antimetabolite chemotherapy drug, which inhibits the proliferation of cancer cells by interfering with DNA synthesis, and belongs to cell cycle-specific drugs. The intermediate refers to a transitional chemical substance generated in the synthesis of 5-fluorouracil, such as sodium fluoride, potassium fluoride and chloroacetic acid. These intermediates are converted into final products through subsequent reactions.

[0003] At present, when sampling 5-fluorouracil intermediates in powder state, in order to ensure the representativeness and uniformity of the sample, a stratified multi-point sampling method is widely used, that is, the sampling cylinder is inserted into different depths of the container, such as the upper, middle and lower layers, to obtain a representative sample. However, part of the 5-fluorouracil intermediates has certain corrosiveness. Although the above method can ensure the representativeness and uniformity of the sample, it needs to insert and take out the sampling cylinder multiple times, which increases the contact frequency of the sampling cylinder and the corrosive medium, and easily causes the corrosion of the valve sealing element of the sampling port and the side wall of the cylinder body. Corrosion can cause the sealing performance of the valve to decrease, and the cylinder body to become thin, perforated or damaged, thereby causing leakage, polluting the workshop environment and harming the health of nearby personnel. SUMMARY

[0004] The technical problem to be solved by the present application is that, at present, when sampling 5-fluorouracil intermediates in powder state, in order to ensure the representativeness and uniformity of the sample, a stratified multi-point sampling method is widely used, that is, the sampling cylinder is inserted into different depths of the container, such as the upper, middle and lower layers, to obtain a representative sample. However, part of the 5-fluorouracil intermediates has certain corrosiveness. Although the above method can ensure the representativeness and uniformity of the sample, it needs to insert and take out the sampling cylinder multiple times, which increases the contact frequency of the sampling cylinder and the corrosive medium, and easily causes the corrosion of the valve sealing element of the sampling port and the side wall of the cylinder body. Corrosion can cause the sealing performance of the valve to decrease, and the cylinder body to become thin, perforated or damaged, thereby causing leakage, polluting the workshop environment and harming the health of nearby personnel.

[0005] The application relates to a sampling device for producing 5-fluorouracil intermediates. The protective assembly is arranged between the sampling cylinder and the receiving seat and is used in cooperation with the sampling cylinder.

[0006] The protective assembly comprises a connecting shell, a plurality of groups of screws are arranged on the outer wall of one end of the connecting shell, the connecting shell is connected to one end of the sampling cylinder away from the limiting sealing ring through the plurality of groups of screws, an electric push rod is arranged on the end of the connecting shell away from the sampling cylinder, a transmission push rod is fixedly connected to the moving end of the electric push rod, and the end of the transmission push rod away from the electric push rod is also connected to the pull rod through screws.

[0007] The protective assembly further comprises a spring column and a rack, the rack is symmetrically fixed on the two sides of the transmission push rod, the spring column is arranged in multiple groups, the fixed ends of the multiple groups of spring columns are symmetrically fixed on the inner wall of the connecting shell, a connecting rod is fixedly connected to the moving end of the spring column, a rotating rod is rotatably connected to the end of the connecting rod away from the spring column, a gear is fixedly connected to the end of the rotating rod away from the connecting rod, a connecting frame is fixedly connected to the middle part of the rotating rod, a semicircular protective cylinder is fixedly connected to the end of the connecting frame away from the rotating rod, and a sealing strip is arranged on the opposite edges of the two groups of semicircular protective cylinders.

[0008] The protective assembly further comprises a first square slide plate and a second square slide plate, the middle part of the first square slide plate is fixedly connected to the connecting rod, a first trapezoidal block is fixedly connected to the end of the first square slide plate away from the sampling cylinder, the middle part of the second square slide plate is fixedly connected to the transmission push rod, and a second trapezoidal block is fixedly connected to the end of the second square slide plate close to the sampling cylinder.

[0009] A switching motor is arranged in the receiving frame, a rotating disc is rotatably connected to the output end of the switching motor, the end of the rotating disc away from the switching motor is fixedly connected to the receiving seat, a controller is arranged at the bottom end of the supporting frame, and a camera is arranged at the top end of the supporting frame.

[0010] A supporting slide rail is slidably connected to the end of the supporting frame away from the first adjusting motor, a second adjusting motor is arranged at one end of the supporting slide rail, a second lead screw is arranged between the two ends of the supporting slide rail and is drivingly connected to the output end of the second adjusting motor, and the second lead screw is in screw-nut pair connection with the supporting frame.

[0011] The support slide rail is fixed at one end with a knocking frame, the knocking frame is installed at one end with a knocking motor, the knocking motor output end is drivenly connected with a protruding block, the knocking frame is slidably connected at the middle with a push plate, the end of the push plate close to the protruding block is circularly arranged, the end of the push plate far from the protruding block is fixedly connected with a knocking rod, the end of the knocking rod far from the push plate penetrates through the inside of the knocking frame and is connected with a knocking ball, and the area of the knocking rod on the knocking frame is sleeved with a return spring.

[0012] The knocking ball is made of rubber and has a hollow inside, and the inside of the knocking ball is provided with a buffer spring.

[0013] The end of the support frame close to the knocking frame is fixedly connected with a placing frame, and the inside of the placing frame is slidably connected with a sample collecting container.

[0014] The two ends of the support slide rail are fixedly connected with mounting frames, and the mounting frames are provided with mounting holes.

[0015] Compared with the prior art, the beneficial effects of the present application are that: through the setting of the two groups of semicircular protection cylinders, when the sampling cylinder is sampling, the two groups of semicircular protection cylinders are automatically kept at a vertical angle with the sampling cylinder, the interference and the introduced frictional resistance of the semicircular protection cylinder to sampling are avoided, and meanwhile, when the sampling cylinder completes sampling and closes the sampling channel, the two groups of semicircular protection cylinders can be close to each other in the vertical state to wrap the outer wall of the sampling cylinder, forming an outer sealing barrier, so that when the sampling cylinder leaks, the leakage and diffusion of the internal sample medium are quickly stopped, the pollution of the continuous diffusion of the medium to the workshop environment and the harm to the health of the nearby personnel are reduced.

[0016] Through the design of the rotating motor, the rotating disc and the receiving seat, efficient rotation of the two groups of sampling cylinders is realized, so that when one group of sampling cylinders is damaged, the other group of sampling cylinders can be immediately put into use to ensure that the sampling work is normally carried out, when the sampling cylinder rotates to the camera position of the camera, the camera will shoot the state of the sampling cylinder, such as the damage of the cylinder body surface, and transmit the image to the monitoring system, so that the operator can view and analyze in real time, so that the personnel can timely switch the standby sampling cylinder, and cooperate with the mechanical sealing structure of the semicircular protection cylinder to reduce the leakage phenomenon caused by corrosion of the sampling cylinder, and further improve the safety of the device.

[0017] Through the starting of the knocking motor, the components such as the protruding block and the push plate can drive the components such as the knocking rod and the knocking ball to reciprocate and knock the outer wall of the sampling cylinder, so as to reduce the sample residue in the inner wall of the sampling cylinder and improve the discharge efficiency of the sample. BRIEF DESCRIPTION OF DRAWINGS

[0018] Figure 1 It is the overall structural schematic diagram of the present application.

[0019] Figure 2It is the structural schematic diagram of the support frame in the application.

[0020] Figure 3 It is the connection schematic diagram of the receiving frame and the rotating disc in the application.

[0021] Figure 4 It is the sectional view structural schematic diagram of the sampling cylinder and the connecting shell in the application.

[0022] Figure 5 It is the unfolded structural schematic diagram of the connecting frame in the application.

[0023] Figure 6 It is the storage structural schematic diagram of the connecting frame in the application.

[0024] Figure 7 It is the running schematic diagram of the second trapezoidal block and the first trapezoidal block in the application.

[0025] Figure 8 It is the structural schematic diagram of the knocking frame in the application.

[0026] Figure 9 It is the sectional view of the knocking ball in the application.

[0027] Figure 10 It is the connection schematic diagram of the placing frame and the sample collecting container in the application.

[0028] In the figure: 1, support frame; 2, first screw rod; 3, first adjusting motor; 4, receiving frame; 5, receiving seat; 6, sampling cylinder; 7, pull rod; 8, sealing block; 9, limiting sealing ring; 10, connecting shell; 11, screw; 12, electric push rod; 13, transmission push rod; 14, spring column; 15, connecting rod; 16, rotating rod; 17, gear; 18, connecting frame; 19, semicircular protective cylinder; 20, rack; 21, first square slide plate; 22, first trapezoidal block; 23, second square slide plate; 24, second trapezoidal block; 25, rotating disc; 26, rotation motor; 27, controller; 28, camera; 29, support slide rail; 30, second adjusting motor; 31, second screw rod; 32, knocking frame; 33, knocking motor; 34, protruding block; 35, push plate; 36, knocking rod; 37, knocking ball; 38, reset spring; 39, placing frame; 40, sample collecting container; 41, buffer spring. DETAILED DESCRIPTION

[0029] In order to make the purpose, technical scheme and advantages of the present application more clear, the present application is further described in detail below in combination with the drawings and examples. It should be understood that the specific examples described herein are only used to explain the present application and do not limit the present application.

[0030] It should be noted that the examples in the present application and the features and technical solutions in the examples can be combined with each other without conflict.

[0031] It should be noted that similar labels and letters in the following figures indicate similar items. Therefore, once an item is defined in one figure, it does not need to be further defined and explained in subsequent figures.

[0032] Example 1 like Figures 1-7 As shown, a sampling device for the production of 5-fluorouracil intermediates includes a support frame 1, a first adjusting motor 3 installed at one end of the support frame 1, a first lead screw 2 connected to the first adjusting motor 3 between the two ends of the support frame 1, a receiving frame 4 connected to the lead screw 2 and its nut pair, a receiving seat 5 installed at one end of the receiving frame 4, multiple sampling cylinders 6 installed on the outer wall of the receiving seat 5, a pull rod 7 slidably connected inside the sampling cylinder 6, a sealing block 8 fixedly connected to one end of the pull rod 7, a limit sealing ring 9 installed on the inner wall of the sampling cylinder 6 near the sealing block 8, and a protective component disposed between the sampling cylinder 6 and the receiving seat 5, the protective component being used in conjunction with the sampling cylinder 6.

[0033] like Figures 1-7 As shown, the protective assembly includes a connecting shell 10. Multiple sets of screws 11 are arranged around the outer wall of one end of the connecting shell 10, connecting it to the end of the sampling cylinder 6 away from the limiting sealing ring 9 via these screws 11. An electric push rod 12 is installed at the end of the connecting shell 10 away from the sampling cylinder 6. A transmission push rod 13 is fixedly connected to the moving end of the electric push rod 12. The end of the transmission push rod 13 away from the electric push rod 12 is also connected to the pull rod 7 via screws 11. A sealing baffle is provided inside the sampling cylinder 6 near the connecting shell 10. A circular groove for the transmission push rod 13 to slide is provided at the center of the sealing baffle to reduce the amount of material entering the connecting shell 10 through the sampling cylinder 6. The protective assembly also includes a spring post 14 and... Racks 20 are symmetrically fixed to both sides of the transmission push rod 13. Multiple sets of spring pillars 14 are arranged, with their fixed ends symmetrically fixed to the inner wall of the connecting shell 10. A connecting rod 15 is fixed to the moving end of each spring pillar 14. A rotating rod 16 is rotatably connected to the end of the connecting rod 15 away from the spring pillar 14. A gear 17 is fixed to the end of the rotating rod 16 away from the connecting rod 15. A connecting frame 18 is fixed to the middle of the rotating rod 16. A semi-circular protective cylinder 19 is fixed to the end of the connecting frame 18 away from the rotating rod 16. Sealing strips are provided at the opposite edges of both sets of semi-circular protective cylinders 19. When the two sets of semi-circular protective cylinders 19 are closed, they form a complete circular cylinder, as described in the instruction manual. Figure Two or Figure ThreeThe protection assembly also includes a first square slide plate 21 and a second square slide plate 23. The first square slide plate 21 is fixedly connected to the connecting rod 15 at the middle portion, and a first trapezoidal block 22 is fixedly connected to the end of the first square slide plate 21 away from the sampling cylinder 6. The second square slide plate 23 is fixedly connected to the transmission push rod 13 at the middle portion, and a second trapezoidal block 24 is fixedly connected to the end of the second square slide plate 23 close to the sampling cylinder 6.

[0034] During operation, the extension of the moving end of the control electric push rod 12 from the fixed end can push the transmission push rod 13 and the pull rod 7 to move away from the connecting shell 10, so that the sealing block 8 slides away from the limiting sealing ring 9 to approach the sampling area, thereby opening the sampling channel of the sampling cylinder 6. During this process, the inclined surface of the second trapezoidal block 24 first contacts the inclined surface of the first trapezoidal block 22. Under the extrusion of the inclined surfaces, the moving end of the spring column 14 gradually and completely extends into the inside of the fixed end. At this time, the second square slide plate 23 contacts the first square slide plate 21 to prevent the moving end of the spring column 14 from resetting, causing mutual interference of the two groups of semicircular protection cylinders 19 due to the joint surface during unfolding. At the same time, under the continuous pushing force of the transmission push rod 13, the rack 20 meshes with the gear 17, and the gear 17 and the rotating rod 16 are continuously rotated, thereby driving the connecting frame 18 to rotate around the rotating rod 16 as the fulcrum, so that the semicircular protection cylinders 19 maintain a perpendicular angle with the sampling cylinder 6, avoiding interference and friction resistance caused by the semicircular protection cylinders 19 during sampling. At this time, the forward rotation of the output end of the first adjusting motor 3 can drive the first screw rod 2 to move the supporting frame 4 vertically close to the sampling area, thereby inserting the sampling cylinder 6 into the sampling area for sampling.

[0035] When the sampling is completed, the first adjusting motor 3 is reversed to rotate, and the first screw rod 2 and the supporting frame 4 are cooperated to vertically move the sampling cylinder 6 away from the sampling area. At the same time, the control electric push rod 12 is moved into the fixed end, and the transmission push rod 13 and the pull rod 7 are cooperated to move the sealing block 8 to the direction close to the limiting sealing ring 9. The sealing block 8 is extruded to the limiting sealing ring 9 to improve the sealing effect of the sampling channel of the sampling cylinder 6. In this process, the second trapezoidal block 24 is gradually moved to the direction close to the second trapezoidal block 24, and the gear 17 is cooperated with the rack 20 to rotate the connecting frame 18 around the rotating rod 16, so that the semi-circular protective cylinder 19 is kept at a horizontal angle with the sampling cylinder 6. When the second trapezoidal block 24 is moved to the initial state, the gear 17 is disengaged from the rack 20, and the spring column 14 is elastically cooperated to push the two groups of semi-circular protective cylinders 19 to be close to each other in the vertical state, and the outer wall of the sampling cylinder 6 is wrapped to form an outer sealing barrier, and a double isolation is formed with the original sealing structure of the sampling cylinder 6 to improve the overall sealing effect. When the sampling cylinder 6 leaks, the leakage and diffusion of the sample medium in the sampling cylinder 6 are quickly stopped, the pollution of the medium to the workshop environment is reduced, and the harm to the health of the nearby personnel is reduced.

[0036] When the sampling cylinder 6 needs to be disassembled, the cross screwdriver is used to remove the screws 11 on the sampling cylinder 6 and the connecting shell 10, and the sampling cylinder 6 is pushed away from the connecting shell 10 to provide space for removing the screws 11 on the pull rod 7 and the transmission push rod 13. Then the screws 11 on the pull rod 7 and the transmission push rod 13 are removed, the overall sampling cylinder 6 is disassembled, and the sealing elements of the sampling cylinder 6, such as the sealing block 8 and the limiting sealing ring 9, are checked and replaced to ensure the sealing performance. Finally, the new or maintained sampling cylinder 6 is reinstalled on the equipment in the reverse order of disassembly, and the screws 11 are tightened.

[0037] As described above, when the sampling cylinder 6 is sampled, the two groups of semi-circular protective cylinders 19 are kept at a vertical angle with the sampling cylinder 6 to avoid interference and friction resistance caused by the semi-circular protective cylinders 19. When the sampling cylinder 6 completes sampling and closes the sampling channel, the two groups of semi-circular protective cylinders 19 can be close to each other in the vertical state to wrap the outer wall of the sampling cylinder 6 to form an outer sealing barrier. When the sampling cylinder 6 leaks, the leakage and diffusion of the sample medium in the sampling cylinder 6 are quickly stopped, the pollution of the medium to the workshop environment is reduced, and the harm to the health of the nearby personnel is reduced.

[0038] Example Two As Figures 1-3As shown, the inside of the receiving frame 4 is mounted with a rotation motor 26, one end of the receiving frame 4 is rotatably connected with a rotating disc 25 drivenly connected with the output end of the rotation motor 26, the end of the rotating disc 25 away from the rotation motor 26 is fixedly connected with the receiving seat 5, the bottom end of the support frame 1 is mounted with a controller 27, and the top end of the support frame 1 is mounted with a camera 28.

[0039] When working, through the design of the rotation motor 26, the rotating disc 25 and the receiving seat 5, efficient rotation of the two groups of sampling cylinders 6 is realized, so that when one group of sampling cylinders 6 is damaged, the other group of sampling cylinders 6 can be immediately put into use, ensuring the normal operation of sampling work. When the sampling cylinder 6 rotates to the camera position of the camera 28, the camera 28 will shoot the state of the sampling cylinder 6, such as the damage of the cylinder body surface, and transmit the image to the monitoring system, so that the operator can view and analyze in real time, so that the personnel can timely switch the standby sampling cylinder 6, and cooperate with the mechanical sealing structure of the above-mentioned semicircular protective cylinder 19 to reduce the leakage phenomenon caused by corrosion of the sampling cylinder 6, and further improve the safety of the device.

[0040] Example three As shown in Figure 1 , Figures 8-10 , one end of the support frame 1 away from the first adjusting motor 3 is slidably connected with a support slide rail 29, one end of the support slide rail 29 is mounted with a second adjusting motor 30, a second lead screw 31 drivenly connected with the output end of the second adjusting motor 30 is arranged between the two ends of the support slide rail 29, and the second lead screw 31 is in screw-nut pair connection with the support frame 1; a knocking frame 32 is fixedly connected to one end of the support slide rail 29, a knocking motor 33 is mounted at one end of the knocking frame 32, a protrusion 34 is drivenly connected to the output end of the knocking motor 33, a push plate 35 is slidably connected to the middle part of the knocking frame 32, one end of the push plate 35 close to the protrusion 34 is circularly arranged, a knocking rod 36 is fixedly connected to one end of the push plate 35 away from the protrusion 34, a knocking ball 37 is connected to one end of the knocking rod 36 away from the push plate 35 through the inside of the knocking frame 32, and a return spring 38 is arranged on the area of the knocking rod 36 located on the knocking frame 32; the knocking ball 37 is made of rubber material and is internally hollow, a buffer spring 41 is arranged in the knocking ball 37, the knocking ball 37 is made of hollow rubber, the internal cavity is filled with silicone oil damping liquid, the buffer spring 41 is combined, the impact energy is converted into heat energy and dissipated, the instantaneous impact force on the sampling cylinder 6 is reduced, and the surface of the knocking ball 37 is preformed with a grid pattern to increase the friction with the cylinder wall and avoid slipping.

[0041] As shown in Figure 10 , one end of the support frame 1 close to the knocking frame 32 is fixedly connected with a placing frame 39, and a sample collection container 40 is slidably connected in the inside of the placing frame 39, wherein the placing frame 39 is a support seat for supporting the sample collection container 40, and the two are arranged in separable sliding mode, so as to quickly position the position of the sample collection container 40 during installation.

[0042] As shown in Figure 1 The mounting frame is fixedly connected with the both ends of the supporting slide rail 29, mounting holes are formed in the mounting frame, the mounting frames on the both sides can increase the contact area between the supporting slide rail 29 and the ground or the table top, improve the stability of the device, and the mounting holes can be further fixed by cooperating with bolts and other fixing members to further improve the stability of the device during sampling.

[0043] During operation, the supporting frame 1 is continuously moved towards the direction of the sample collecting container 40 by controlling the second adjusting motor 30 to rotate in the forward direction, and vice versa, the supporting frame 1 is continuously moved away from the sample collecting container 40 by controlling the second adjusting motor 30 to rotate in the reverse direction, so as to sample intermediates at different positions and improve the diversity of the sampled samples, when the sampling cylinder 6 moves to the specified discharging area of the sample collecting container 40, the discharging channel of the sampling cylinder 6 is opened, at this time, the two groups of semi-circular protective cylinders 19 are automatically opened, at this time, the sample is discharged into the sample collecting container 40 through the discharging channel, during the process, the knocking motor 33 is started, the output end of the knocking motor 33 drives the protruding block 34 to rotate, intermittently presses the one end of the push plate 35 which is circular, and cooperates with the elastic action of the reset spring 38, so that the knocking rod 36 pushes the knocking ball 37 to reciprocate and knocks the outer wall of the sampling cylinder 6, reduces the residue of the sample on the inner wall of the sampling cylinder 6, and improves the discharge efficiency of the sample.

[0044] The working principle of the present application is as follows: when it is necessary to discharge the sample, the insertion position of the sampling cylinder 6 is adjusted by controlling the second adjusting motor 30 to rotate in the reverse direction according to the position of the sampling area, then the moving end of the electric push rod 12 is controlled to extend from the fixed end, the transmission push rod 13 and the pull rod 7 are pushed to move away from the connecting shell 10, the sampling channel of the sampling cylinder 6 is opened, and the two groups of semi-circular protective cylinders 19 are automatically expanded under the elastic action of the second trapezoidal block 24, the first trapezoidal block 22, the rack 20, the gear 17 and the spring column 14, then the sample sampling depth is controlled, the output end of the first adjusting motor 3 is controlled to rotate in the forward direction, so as to drive the sampling cylinder 6 to move vertically towards the sampling area and insert the sampling cylinder 6 into the sampling area for sampling.

[0045] After sampling is completed, the output end of the first adjusting motor 3 is controlled to rotate in the reverse direction, so as to vertically move the sampling cylinder 6 away from the sampling area, at the same time, the moving end of the electric push rod 12 is controlled to extend into the fixed end, the sampling channel of the sampling cylinder 6 is closed under the action of the transmission push rod 13 and the pull rod 7, and the two groups of semi-circular protective cylinders 19 are close to each other in the vertical state under the elastic action of the above-mentioned second trapezoidal block 24, the first trapezoidal block 22, the rack 20, the gear 17 and the spring column 14, so as to wrap the outer wall of the sampling cylinder 6 and form an outer sealing barrier.

[0046] When the sample inside the sampling cylinder 6 needs to be discharged, the second adjusting motor 30 is controlled to rotate in the positive direction, which drives the support frame 1 to continuously move towards the sample collecting container 40. When the sampling cylinder 6 moves to the designated discharging area of the sample collecting container 40, the sampling channel of the sampling cylinder 6 is opened, and the two groups of semicircular protective cylinders 19 are automatically opened. At this time, the sample is discharged into the sample collecting container 40 through the sampling channel, and the discharging operation is completed. In this process, the knocking motor 33 is started, the output end of the knocking motor 33 drives the protruding block 34 to rotate, intermittently presses the circular end of the push plate 35, and cooperates with the elastic action of the reset spring 38, so that the knocking rod 36 pushes the knocking ball 37 to reciprocate and knock the outer wall of the sampling cylinder 6, reduces the sample residue on the inner wall of the sampling cylinder 6, and improves the discharge efficiency of the sample.

[0047] When the sampling cylinder 6 needs to be disassembled, use a cross screwdriver to remove the screws 11 on the sampling cylinder 6 and the connecting shell 10, push the sampling cylinder 6 away from the connecting shell 10 to provide space for removing the screws 11 on the pull rod 7 and the transmission push rod 13, then remove the screws 11 on the pull rod 7 and the transmission push rod 13, complete the overall disassembly of the sampling cylinder 6, and check and replace the sealing elements of the sampling cylinder 6, such as the sealing block 8 and the limiting sealing ring 9, to ensure the sealing performance. Finally, according to the reverse order of disassembly, the new or maintained sampling cylinder 6 is reinstalled on the equipment, and the screws 11 are tightened.

[0048] In the present application, the description of the direction and relative position relationship of the structure, such as front, back, left, right, up and down, does not constitute a limitation on the present application, but is only for convenience of description.

Claims

1. A sampling device for 5-fluorouracil intermediate production, characterized by: The utility model provides a support frame (1) one end is equipped with first adjusting motor (3), be provided with with first adjusting motor (3) drive connection between both ends of support frame (1) first screw rod (2), first screw rod (2) screw nut pair connection has the receiving frame (4), the receiving frame (4) one end is equipped with receiving seat (5), receiving seat (5) outside wall is equipped with multiple groups of sampling cylinder (6), sampling cylinder (6) inside slide connection has pull rod (7), pull rod (7) one end is fixed with sealing block (8), sampling cylinder (6) is close to sealing block (8) one end inner wall installation limit seal ring (9), The protective assembly is arranged between the sampling cylinder (6) and the receiving seat (5), and is used in cooperation with the sampling cylinder (6).

2. A sampling device for the production of 5-fluorouracil intermediates according to claim 1, characterized in that: The protective assembly includes a connecting shell (10), a plurality of screws (11) are arranged around the outer wall of one end of the connecting shell (10), and the connecting shell (10) is connected to one end of the sampling cylinder (6) away from the limit seal ring (9) through the plurality of screws (11). An electric push rod (12) is installed at one end of the connecting shell (10) away from the sampling cylinder (6). A transmission push rod (13) is fixedly connected to the moving end of the electric push rod (12). The transmission push rod (13) is connected to the pull rod (7) through the screw (11) at one end away from the electric push rod (12).

3. A sampling device for the production of 5-fluorouracil intermediates according to claim 2, characterized in that: The protective assembly further includes a spring column (14) and a rack (20). The rack (20) is symmetrically fixed on both sides of the transmission push rod (13). The spring column (14) is arranged in multiple groups. The fixed ends of the multiple spring columns (14) are symmetrically fixed to the inner wall of the connecting shell (10). The moving end of the spring column (14) is fixedly connected to a connecting rod (15). A rotating rod (16) is rotatably connected to one end of the connecting rod (15) away from the spring column (14). A gear (17) is fixedly connected to one end of the rotating rod (16) away from the connecting rod (15). A connecting frame (18) is fixedly connected to the middle of the rotating rod (16). A semicircular protective cylinder (19) is fixedly connected to one end of the connecting frame (18) away from the rotating rod (16). Sealing strips are provided on the opposite edges of the two semicircular protective cylinders (19).

4. A sampling device for the production of 5-fluorouracil intermediates according to claim 3, characterized in that: The protective assembly further includes a first square slide plate (21) and a second square slide plate (23). The first square slide plate (21) is fixedly connected to the connecting rod (15) in the middle. A first trapezoidal block (22) is fixedly connected to one end of the first square slide plate (21) away from the sampling cylinder (6). The second square slide plate (23) is fixedly connected to the transmission push rod (13) in the middle. A second trapezoidal block (24) is fixedly connected to one end of the second square slide plate (23) close to the sampling cylinder (6).

5. A sampling device for the production of 5-fluorouracil intermediates according to claim 1, characterized in that: A wheel changing motor (26) is installed inside the receiving frame (4). A turntable (25) is rotatably connected to one end of the receiving frame (4) and is drive-connected to the output end of the wheel changing motor (26). The turntable (25) is fixedly connected to the receiving seat (5) at one end away from the wheel changing motor (26). A controller (27) is installed at the bottom end of the support frame (1). A camera (28) is installed at the top end of the support frame (1).

6. A sampling device for the production of 5-fluorouracil intermediates according to claim 1, characterized in that: The support frame (1) is slidably connected with a support slide rail (29) at one end away from the first adjusting motor (3), one end of the support slide rail (29) is provided with the second adjusting motor (30), the support slide rail (29) is provided with the second screw rod (31) driven connected with the output end of the second adjusting motor (30) between two ends, and the second screw rod (31) is connected with the support frame (1) in a screw nut pair.

7. A sampling device for the production of 5-fluorouracil intermediates according to claim 6, characterized in that: One end of the support slide rail (29) is fixedly connected with a knocking frame (32), one end of the knocking frame (32) is provided with the knocking motor (33), the output end of the knocking motor (33) is driven connected with the protruding block (34), the knocking frame (32) is slidably connected with the push plate (35) in the middle, one end of the push plate (35) is circularly provided at the end portion close to the protruding block (34), the knocking frame (32) is fixedly connected with the knocking rod (36) at one end away from the protruding block (34), one end of the knocking rod (36) away from the push plate (35) penetrates the inside of the knocking frame (32) and is connected with the knocking ball (37), and the area of the knocking rod (36) on the knocking frame (32) is sleeved with the reset spring (38).

8. A sampling device for the production of 5-fluorouracil intermediates according to claim 7, characterized in that: The knocking ball (37) is made of rubber material and is hollow, and the knocking ball (37) is provided with the buffer spring (41) inside.

9. A sampling device for the production of 5-fluorouracil intermediates according to claim 7, characterized in that: One end of the support frame (1) close to the knocking frame (32) is fixedly connected with the placing frame (39), and the inside of the placing frame (39) is slidably connected with the sample collecting container (40).

10. A sampling device for the production of 5-fluorouracil intermediates according to claim 6, characterized in that: Both ends of the support slide rail (29) are fixedly connected with the mounting frame, and the mounting hole is formed in the mounting frame.

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