A high-calcium-content, highly absorbable calcium-vitamin D composition and its preparation method

Abstract

This invention relates to the field of food technology, specifically to a high-calcium-content, highly absorbable calcium-vitamin D composition and its preparation method. The high-calcium-content, highly absorbable calcium-vitamin D composition, by weight, comprises the following components per 1000 parts of calcium-vitamin D composition: 100-300 parts calcium citrate, 60-130 parts xylitol, 0.1-5 parts L-calcium lactate, 0.001-0.01 parts vitamin D3, 2-7 parts pH adjuster, 5-17 parts colloid, 1-10 parts caprylic / capric triglyceride, and 1-5 parts vitamin C, with the balance being water; the colloid includes triazine gum, gum arabic, and xanthan gum. The calcium-vitamin D composition of this invention has the advantages of higher calcium content, better stability and taste, and higher absorption rate.

Description

Technical Field

[0001] This invention relates to the field of food technology, specifically to a high-calcium-content, highly absorbable calcium-vitamin D composition and its preparation method. Background Technology

[0002] Calcium is crucial for human growth and development, but the body cannot synthesize it and must rely entirely on external supplementation. Calcium deficiency can easily lead to various diseases, such as rickets in children, premature aging in adults, pregnancy-induced hypertension in pregnant women, and osteoporosis and bone hyperplasia in the elderly, increasing the risk of fractures. Nutritional surveys indicate that calcium intake is generally low, averaging around 400mg per person per day, while the "Chinese Dietary Reference Intakes: 2023 Edition" recommends a daily calcium intake of 800mg for adults and 1000mg for adolescents. Therefore, calcium supplementation has become a key concern for all population groups.

[0003] Currently, most calcium-supplementing health foods or foods on the market are in tablet or capsule form. These products often have large particles that are difficult to swallow. Powder and granule calcium supplements are also common, but they require dissolving in water. Liquid dosage forms offer the advantage of convenience, but are relatively rare on the market. The main reasons include: ① Solubility and stability: Most calcium-derived compounds are insoluble or sparingly soluble in water, such as calcium carbonate, calcium sulfate, and calcium citrate. Some organic calcium compounds, such as calcium gluconate and calcium lactate, are soluble in hot water, but their solubility decreases as the temperature decreases. Some amino acid chelated calcium compounds, such as calcium glycinate and calcium aspartate, have good water solubility, but their stability deteriorates when the calcium content reaches 30 mg / ml, and they are prone to precipitation after prolonged storage. ② Flavor: Most calcium-derived compounds have unpleasant flavors, and liquid dosage forms result in large doses and poor sensory acceptance.

[0004] Chinese Patent Publication No. CN107411096A discloses a liquid calcium supplement functional food with a calcium content of 50-70 mg / mL and good flavor and texture. It is mainly made from the following ingredients in parts by weight: microencapsulated calcium containing 5000-7000 parts calcium, 0.5-1 part vitamin K, 0.2-0.4 parts xanthan gum, 10-15 parts sucrose, 4-6 parts fructose, 0.1-0.3 parts citric acid, 0.1-0.3 parts edible flavoring, and 0.1-0.2 parts potassium sorbate. However, this food requires microencapsulation of the calcium, making the preparation process relatively complex, and its stability and taste need further improvement.

[0005] Chinese patent publication No. CN116616449A discloses an acidic antibacterial system stable carrying high calcium and vitamin D drink and a preparation method thereof, the drink includes the following components by mass fraction: colloid 0.5-5 parts, acidity regulator 2-15 parts, antioxidant 0.1-5 parts, calcium source 40-230 parts, embedded vitamin D 0.01-1 part, sweetener 100-300 parts, flavoring agent 0.01-2 parts; water 200-800 parts; the pH value of the acidic antibacterial system stable carrying high calcium and vitamin D drink is 3-4.5, the vitamin D content is ≥50ug / 100mL, and the calcium content is ≥2500mg / 100mL. The drink improves the calcium content that can be long-term stably suspended and carried under a single colloid acidic system by adjusting the amount of acid and colloid; the addition of antioxidant in the system and the embedding of vitamin D can realize high content of vitamin D under an acidic system, and the vitamin D content is stable and not easy to degrade. However, the drink needs to embed vitamin D, and the calcium content, stability and taste need to be further improved.

[0006] Therefore, it is necessary to develop a high calcium content, high absorption type calcium vitamin D composition and a preparation method thereof which can solve the above technical problems. SUMMARY

[0007] The purpose of the present application is to overcome the shortcomings of the prior art and provide a high calcium content, high absorption type calcium vitamin D composition and a preparation method thereof which have higher calcium content, better stability and taste, and higher absorption rate.

[0008] The present application is realized by the following technical solutions:

[0009] The present application provides a high calcium content, high absorption type calcium vitamin D composition in the first aspect, which includes the following components by weight fraction: 100-300 parts of calcium citrate, 60-130 parts of xylitol, 0.1-5 parts of L-calcium lactate, 0.001-0.01 parts of vitamin D3, 2-7 parts of pH regulator, 5-17 parts of colloid, 1-10 parts of caprylic capric glyceride, and 1-5 parts of vitamin C, and the balance is water; the colloid includes trizan gum, acacia gum and xanthan gum.

[0010] As an embodiment of the present application, the mass ratio of the trizan gum, acacia gum and xanthan gum is (1-4):(5-8):(1-3).

[0011] As an embodiment of the present application, the calcium vitamin D composition further includes oligoisomaltose.

[0012] Preferably, the amount of oligoisomaltose is 5-30 parts.

[0013] As an embodiment of the present application, the calcium vitamin D composition further comprises a flavoring substance, preferably in an amount of 1-5 parts.

[0014] Preferably, the flavoring substance comprises at least one of blood orange concentrate and kaman orange concentrate.

[0015] As an embodiment of the present application, the calcium vitamin D composition has a pH of 4.0-5.0, preferably 4.0-4.5.

[0016] As an embodiment of the present application, the pH regulator comprises at least one of citric acid, malic acid and lactic acid. A richer taste can be obtained when citric acid is combined with malic acid.

[0017] The second aspect of the present application provides a preparation method of the high calcium content, high absorption calcium vitamin D composition as described above, comprising the following steps:

[0018] (1) mixing vitamin D3 with part of caprylic acid and capric acid glyceride, homogenizing to obtain a pre-emulsion;

[0019] (2) dissolving vitamin C in water to obtain a vitamin C solution;

[0020] (3) mixing calcium citrate and L-calcium lactate to obtain calcium powder, adding water and homogenizing to obtain a mixture A;

[0021] (4) mixing the colloid and xylitol, adding or not adding low oligomeric isomalt, to obtain material a, adding water and homogenizing to obtain a mixture B;

[0022] (5) adding the pre-emulsion to the mixture B, and then adding the mixture A, the remaining caprylic acid and capric acid glyceride and the vitamin C solution to obtain a mixture C;

[0023] (6) adding or not adding the flavoring substance to the mixture C, then adding the pH regulator, adding water to constant volume, adjusting the pH, sterilizing and cooling to obtain the product.

[0024] As an embodiment of the present application, the homogenization parameters in step (1) are: temperature 40-50℃, time 8-15min, pressure 140-160MPa.

[0025] As an embodiment of the present application, the particle size of the lipid droplets in the pre-emulsion in step (1) is ≤0.5μm.

[0026] As an embodiment of the present application, the mass ratio of the part of caprylic acid and capric acid glyceride to vitamin D3 in step (1) is 300-500:1.

[0027] As an embodiment of the present application, the mass ratio of vitamin C to water in step (2) is 1:2-5.

[0028] As an embodiment of the present application, the mass ratio of calcium powder to water in step (3) is 1:1.3-3.

[0029] As an embodiment of the present application, the temperature of the water in step (4) is 60-70℃.

[0030] As an embodiment of the present application, the mass ratio of the material a to water in step (4) is 1:1.3-3.

[0031] As an embodiment of the present application, the pH regulator is added in the form of a solution in step (6), and the mass ratio of the pH regulator to water in the solution is 1:2-5.

[0032] Preferably, the preparation method comprises the following steps:

[0033] (1) Vitamin D3 is mixed with 300-500 times of caprylic acid and capric acid glyceride, and homogenized at 40-50℃ and 140-160 MPa for 8-15 min, so that the fat droplets are refined to ≤0.5 μm, the taste fineness is improved, and a pre-emulsion is obtained;

[0034] (2) Vitamin C is dissolved in purified water by stirring until clear, to obtain a vitamin C solution, and the mass ratio of vitamin C to water is 1:2-5;

[0035] (3) Calcium citrate and L-calcium lactate are mixed to obtain calcium powder, which is added to water, and the mass ratio of calcium powder to water is 1:1.3-3, and homogenized at 25-35 MPa for 8-15 min to obtain a mixture A;

[0036] (4) Water is added to a tank, and heated to 60-70℃, and a material a is obtained by mixing a colloid and xylitol with or without the addition of low oligomaltose, and then added to the tank (the mass ratio of the material a to water is 1:1.3-3), and homogenized at 25-35 MPa for 10-20 min to disperse uniformly without obvious particles, and then the temperature is reduced to 40-50℃ to protect the heat sensitivity of the colloid and prevent degradation, and filtered through a 200-mesh filter screen to obtain a mixture B; the colloid and xylitol are dissolved after dry mixing to avoid caking; homogenization circulation realizes sufficient hydration and dispersion, and forms a uniform colloid mesh structure.

[0037] (5) The pre-emulsion is added to the mixture B and stirred uniformly, and then the mixture A and the remaining caprylic acid and capric acid glyceride are added, and homogenized at 50 MPa for 45 min to break the calcium powder particles to 5 μm, and then the vitamin C solution is added to obtain a mixture C.

[0038] (6) The mixture C is added with or without flavoring substances, and then a pH regulator is added into 2-5 times of water to be stirred and dissolved, and then is put into the mixture C, and is stirred for 15 min, and is added with water to 1000 parts by weight, and is stirred for 30 min, and the pH is between 4-5, and is sterilized, and is cooled to obtain.

[0039] The beneficial effects of the present application are:

[0040] The present application adds caprylocaproyl glycerides for dispersing fat-soluble vitamin D3 and calcium source, which ensures high calcium content, improves the suspension stability and chemical stability of the composition, and also improves the sensory effect and absorption effect of the composition.

[0041] The present application uses xanthan gum, gum arabic and traganth to form a colloidal space network, which is beneficial to locking the specific calcium source and the lipid droplets formed by caprylocaproyl glycerides and vitamin D3, and preventing precipitation and stratification. Especially, the xanthan gum, gum arabic and traganth in a specific ratio can ensure high calcium content (the calcium content is as high as 30%), significantly improve the suspension stability and chemical stability of the composition, and also improve the sensory effect of the composition.

[0042] The present application uses calcium citrate and L-calcium lactate as calcium sources, which has high solubility in an acidic environment, high bioavailability, and good taste compared with other calcium sources. The L-calcium lactate is absorbed quickly, and the calcium citrate can be absorbed for a long time. The use of the absorption characteristics of both is beneficial to realize rapid and long-acting absorption of calcium source.

[0043] In the preparation process of the present application, by optimizing the mixing order of each raw material and the homogenization process parameters, the product has high stability under high calcium content and high vitamin D3 content, prevents product stratification and product degradation, and improves the sensory effect of the product. DETAILED DESCRIPTION

[0044] The advantages and characteristics of the present application will be more apparent with the description. However, these examples are only exemplary and do not constitute any limitation on the scope of the present application. Those skilled in the art should understand that the details and forms of the technical solutions of the present application can be modified or replaced without departing from the spirit and scope of the present application, and such modifications and replacements all fall within the protection scope of the present application.

[0045] Example 1

[0046] A high calcium content, high absorption type calcium vitamin D composition, according to the weight fraction, each 1000 parts of calcium vitamin D composition, the components are as follows: 235 parts of calcium citrate, 130 parts of xylitol, 0.1 parts of L-calcium lactate, 0.008 parts of vitamin D3, 3 parts of citric acid, 10.5 parts of colloid, 5.2 parts of caprylic capric glyceride and 3 parts of vitamin C, the balance is water, the colloid includes gum arabic, gum arabic and xanthan gum, the mass ratio of the three is 1:5:1.

[0047] The preparation method of the high calcium content, high absorption type calcium vitamin D composition comprises the following steps:

[0048] (1) Mix vitamin D3 with 400 times of caprylic capric glyceride, homogenize at 45℃, 150 MPa for 10 min, and the lipid droplets are refined to ≤0.5μm to obtain a pre-emulsion;

[0049] (2) Dissolve vitamin C in purified water to obtain a vitamin C solution, the mass ratio of vitamin C to water is 1:3;

[0050] (3) Mix calcium citrate and L-calcium lactate to obtain calcium powder, add water, the mass ratio of calcium powder to water is 1:1.5, homogenize at 30 MPa for 10 min to obtain mixture A;

[0051] (4) Add water to the tank, heat to 65℃, mix the colloid and xylitol to obtain material a, put into the tank (the mass ratio of material a to water is 1:1.5), homogenize at 30 MPa for 15 min to disperse uniformly without obvious particles, reduce the temperature to 45℃, filter through a 200 mesh filter screen to obtain mixture B;

[0052] (5) Add the pre-emulsion to mixture B, stir uniformly, add mixture A and the remaining caprylic capric glyceride, homogenize at 50 MPa for 45 min to break the calcium powder particles to 5μm, add the vitamin C solution to obtain mixture C.

[0053] (6) Dissolve citric acid in 3 times of water, put into mixture C, stir for 15 min, add water to 1000 parts by weight, stir for 30 min, the pH is between 4.4-4.6, sterilize, cool, and obtain the product.

[0054] Example 2

[0055] A high calcium content, high absorption type calcium vitamin D composition, according to the weight parts, the components in 1000 parts of the calcium vitamin D composition are as follows: 100 parts of calcium citrate, 100 parts of xylitol, 5 parts of calcium L-lactate, 0.001 parts of vitamin D3, 2 parts of lactic acid, 5 parts of colloid, 1.3 parts of caprylic capric glyceride and 1 part of vitamin C, 5 parts of isomalto-oligosaccharide, and the rest is water, the colloid includes gum tragacanth, gum arabic and xanthan gum, and the mass ratio of the three is 4:8:3.

[0056] The preparation method of the high calcium content, high absorption type calcium vitamin D composition comprises the following steps:

[0057] (1) Vitamin D3 is mixed with 300 times of caprylic capric glyceride, homogenized at 40℃ and 160MPa for 8min, the fat droplets are refined to ≤0.5μm, the taste fineness is improved, and a pre-emulsion is obtained;

[0058] (2) Vitamin C is stirred and dissolved in purified water until clear to obtain a vitamin C solution, and the mass ratio of vitamin C to water is 1:2;

[0059] (3) Calcium citrate and calcium L-lactate are mixed to obtain calcium powder, which is added into water, and the mass ratio of calcium powder to water is 1:3, and homogenized at 35MPa for 8min to obtain a mixture A;

[0060] (4) Water is added into a tank, heated to 60℃, and colloid and xylitol are mixed to obtain material a, which is put into the tank (the mass ratio of material a to water is 1:3), and homogenized at 35MPa for 10min until uniformly dispersed without obvious particles, and then the temperature is reduced to 40℃ to protect the heat sensitivity of the colloid and prevent degradation, and filtered through a 200 mesh filter screen to obtain a mixture B;

[0061] (5) The pre-emulsion is added into the mixture B and stirred uniformly, the mixture A and the remaining caprylic capric glyceride are added, and homogenized at 50MPa for 45min to break the calcium powder particles to 5μm, and then the vitamin C solution is added to obtain a mixture C.

[0062] (6) Lactic acid is added into 2 times of water and stirred and dissolved, and then put into the mixture C, stirred for 15min, supplemented with water to 1000 parts by weight, and stirred for 30min, and the pH is between 4.0-4.2, sterilized, and cooled to obtain the product.

[0063] Example 3

[0064] A high calcium content, high absorption type calcium vitamin D composition, according to the weight parts, the components in 1000 parts of the calcium vitamin D composition are as follows: 300 parts of calcium citrate, 60 parts of xylitol, 0.1 parts of calcium L-lactate, 0.01 parts of vitamin D3, 7 parts of malic acid, 16.5 parts of glue, 10 parts of caprylic capric glyceride and 5 parts of vitamin C, 30 parts of isomalto-oligosaccharide, and the balance is water, and the glue includes gum tragacanth, gum arabic and xanthan gum, and the mass ratio of the three is 3:6:2.

[0065] The preparation method of the high calcium content, high absorption type calcium vitamin D composition comprises the following steps:

[0066] (1) Vitamin D3 is mixed with 500 times of caprylic capric glyceride, homogenized at 50°C and 140MPa for 15min, the fat droplets are refined to ≤0.5μm, the taste fineness is improved, and a pre-emulsion is obtained;

[0067] (2) Vitamin C is dissolved in purified water until clear to obtain a vitamin C solution, and the mass ratio of vitamin C to water is 1:5;

[0068] (3) Calcium citrate and calcium L-lactate are mixed to obtain calcium powder, the calcium powder is added into water, the mass ratio of calcium powder to water is 1:1.3, and homogenization is carried out at 25MPa for 15min to obtain a mixture A;

[0069] (4) Water is added into a tank, heated to 70°C, glue and xylitol are mixed to obtain material a, which is put into the tank (the mass ratio of material a to water is 1:1.3), and homogenization is carried out at 25MPa for 20min until the material is uniformly dispersed without obvious particles, the temperature is reduced to 50°C, the heat sensitivity of the glue is protected, degradation is prevented, and the mixture is filtered through a 200 mesh filter screen to obtain a mixture B;

[0070] (5) The pre-emulsion is added into the mixture B and stirred uniformly, the mixture A and the remaining caprylic capric glyceride are added, homogenization is carried out at 50MPa for 45min to break the calcium powder particles to 5μm, the vitamin C solution is added, and a mixture C is obtained.

[0071] (6) Malic acid is added into 5 times of water and stirred to dissolve, the mixture C is added, stirred for 15min, the water is added to 1000 parts by weight, stirred for 30min, the pH is between 4.8 and 5.0, sterilized, and cooled to obtain the product.

[0072] Example 4

[0073] The main difference between example 1 and example 4 is the different formula, and the specific formula is as follows:

[0074] A high calcium content, high absorption type calcium vitamin D composition, according to the weight parts, the components in 1000 parts of the calcium vitamin D composition are as follows: 235 parts of calcium citrate, 130 parts of xylitol, 0.1 parts of calcium L-lactate, 0.008 parts of vitamin D3, 3 parts of citric acid, 10.5 parts of colloid, 5.2 parts of caprylic capric glycerin, 3 parts of vitamin C, 18 parts of isomalto-oligosaccharide, 2 parts of blood orange concentrate and 2 parts of kumquat concentrate, and the balance is water, and the colloid includes gum tragacanth, gum arabic and xanthan gum, and the mass ratio of the three is 1:5:1.

[0075] The preparation method of the high calcium content, high absorption type calcium vitamin D composition comprises the following steps:

[0076] (1) Vitamin D3 is mixed with 400 times of caprylic capric glycerin, homogenized at 45°C and 150 MPa for 10 min, the fat droplets are refined to ≤0.5 μm, and a pre-emulsion is obtained;

[0077] (2) Vitamin C is stirred and dissolved in purified water until clear to obtain a vitamin C solution, and the mass ratio of vitamin C to water is 1:3;

[0078] (3) Calcium citrate and calcium L-lactate are mixed to obtain calcium powder, which is added into water, and the mass ratio of calcium powder to water is 1:1.5, and homogenized at 30 MPa for 10 min to obtain a mixture A;

[0079] (4) Water is added into a tank, heated to 65°C, the colloid and xylitol are mixed, isomalto-oligosaccharide is added, a material a is obtained, which is put into the tank (the mass ratio of material a to water is 1:1.5), and homogenized at 30 MPa for 15 min until uniformly dispersed without obvious particles, the temperature is reduced to 45°C, filtered through a 200 mesh filter screen to obtain a mixture B;

[0080] (5) The pre-emulsion is added into the mixture B and stirred uniformly, the mixture A and the remaining caprylic capric glycerin are added, and homogenized at 50 MPa for 45 min to break the calcium powder particles to 5 μm, the vitamin C solution is added to obtain a mixture C.

[0081] (6) The blood orange concentrate and the kumquat concentrate are added into the mixture C, citric acid is added into 3 times of water and stirred and dissolved, put into the mixture C, stirred for 15 min, the water is added to 1000 parts by weight, stirred for 30 min, the pH is between 4.4-4.6, sterilized, and cooled to obtain the product.

[0082] Comparative Example 1

[0083] The difference from Example 1 is only that the colloid composition is different, only xanthan gum and gum arabic are contained, the mass ratio of the two is 1:5, the total amount of the colloid is unchanged, and the other conditions are the same.

[0084] Comparative Example 2

[0085] The difference from Example 1 is only in the colloid composition, only containing triazin gum and arabic gum, the mass ratio of which is 1:5, the total amount of the colloid is unchanged, and the rest of the conditions are the same.

[0086] Comparative Example 3

[0087] The difference from Example 1 is only in the colloid composition, only containing triazin gum and xanthan gum, the mass ratio of which is 1:1, the total amount of the colloid is unchanged, and the rest of the conditions are the same.

[0088] Comparative Example 4

[0089] The difference from Example 1 is only in the colloid composition, the mass ratio of triazin gum, arabic gum and xanthan gum is 0.2:4:1, the total amount of the colloid is unchanged, and the rest of the conditions are the same.

[0090] Comparative Example 5

[0091] The difference from Example 1 is only in the colloid composition, the mass ratio of triazin gum, arabic gum and xanthan gum is 2:9:1, the total amount of the colloid is unchanged, and the rest of the conditions are the same.

[0092] Comparative Example 6

[0093] The difference from Example 1 is only that octanoic acid and decanoic acid glycerides are not added, and the rest of the conditions are the same.

[0094] Comparative Example 7

[0095] The difference from Example 1 is only in the timing of adding octanoic acid and decanoic acid glycerides, which is only added in step (1), and not added in step (5).

[0096] Comparative Example 8

[0097] The difference from Example 1 is only in the composition of the calcium source, calcium citrate and L-calcium lactate are replaced by calcium gluconate and calcium phosphate, the total amount of the calcium source is unchanged, and the rest of the conditions are the same, as follows:

[0098] A high-calcium, high-absorption calcium vitamin D composition, according to weight parts, the components in 1000 parts of the calcium vitamin D composition are as follows: 235 parts of calcium gluconate, 130 parts of xylitol, 0.1 parts of calcium phosphate, 0.008 parts of vitamin D3, 3 parts of citric acid, 10.5 parts of colloid, 5.2 parts of octanoic acid and decanoic acid glycerides, and 3 parts of vitamin C, the balance being water, the colloid including triazin gum, arabic gum and xanthan gum, the mass ratio of which is 1:5:1.

[0099] Comparative Example 9

[0100] The difference from Example 1 is only in the composition of calcium source, and calcium gluconate and calcium phosphate are added, the total amount of calcium source is unchanged, and the rest of the conditions are the same, as follows:

[0101] A high calcium content and high absorption type calcium vitamin D composition, in terms of weight fraction, the components in 1000 parts of the calcium vitamin D composition are as follows: 227 parts of calcium citrate, 2.7 parts of calcium gluconate, 2.7 parts of calcium phosphate, 130 parts of xylitol, 2.7 parts of calcium L-lactate, 0.008 parts of vitamin D3, 3 parts of citric acid, 10.5 parts of colloid, 5.2 parts of caprylic capric glyceride and 3 parts of vitamin C, and the balance is water, and the colloid includes gum tragacanth, gum arabic and xanthan gum, and the mass ratio of the three is 1:5:1.

[0102] Suspension stability test of Test Example 1

[0103] The high calcium content and high absorption type calcium vitamin D compositions prepared in Examples 1-4 and Comparative Examples 1-7 are put into test tubes for accelerated test to test the suspension stability, and the conditions of the accelerated test are 50℃ and 75% relative humidity, and the appearance is detected every month, and the results are shown in Table 1.

[0104] Table 1 Suspension stability test results

[0105]

[0106] Note: "Layering" means that calcium precipitate appears at the bottom, indicating that the suspension state formed by calcium and colloid is destroyed; "water separation" means that a transparent water layer containing neither colloid nor calcium appears in the upper layer of the composition in the test tube, and the lower layer is a concentrated gel precipitate that loses fluidity, which may be related to the agglomeration, excessive amount and unevenness of the colloid; "yes" indicates that there is obvious layering or obvious water separation; "no" indicates that there is no layering or water separation.

[0107] Microbial test of Test Example 2

[0108] The high calcium content and high absorption type calcium vitamin D compositions prepared in Examples 1-4 are subjected to accelerated test to test the number of microorganisms, and the conditions of the accelerated test are 50℃ and 75% relative humidity, and the test is performed once a month, and the results are shown in Table 2.

[0109] Table 2 Microbial test results

[0110]

[0111] Note: n is the number of samples; C is the number of samples with allowable colony count value between m and M; m is the qualified limit, and all results below this limit are qualified; M is the unqualified limit, and all results above this limit are unqualified.

[0112] Vitamin D3 content test of Test Example 3

[0113] The high calcium content, high absorbability calcium vitamin D compositions prepared in Examples 1-4 and Comparative Examples 1-7 were subjected to accelerated test to test the content of vitamin D3, and the conditions of the accelerated test were 50°C, 75% relative humidity, and the test was performed once a month, and the results are shown in Table 3.

[0114] Retention rate of vitamin D3 content = value detected at a specific time / theoretical feeding value x 100%.

[0115] Table 3 Test results of vitamin D3 content

[0116]

[0117] Test Example 4 Taste test

[0118] Thirty sensory evaluators were selected, and the taste, aroma and preference of the products were subjected to sensory evaluation according to the evaluation criteria shown in Table 4, and the taste and aroma were evaluated using 0-3 points, and the preference was evaluated using 0-6 points, and the results are shown in Table 5.

[0119] Table 4 Sensory evaluation criteria

[0120]

[0121] Table 5 Sensory evaluation results

[0122]

[0123] Test Example 5 In vitro simulated digestion test

[0124] The high calcium content, high absorption type calcium vitamin D compositions prepared from Examples 1-4 and Comparative Examples 6, 8 and 9 were subjected to in vitro simulated digestion testing. Before testing, the calcium content and vitamin D3 content of each product were determined. Then, 1 g of the calcium vitamin D composition was added to 50 mL of water, the pH was adjusted to 1.5 using 1 mol / L HCl solution, and the mixture was allowed to stand at 37°C for 10 min. Then, 0.2 mL of simulated gastric juice (1 mol / L HCl solution + 5 wt% pepsin, based on the total weight of the gastric juice) was added, and the mixture was allowed to digest for 2 h under the following conditions: constant temperature water bath and magnetic stirring pot, 37°C, 100 r / min. Then, 0.01 mol / L PBS buffer and 1 mol / L NaOH were added to adjust the pH to 7.4, and 0.02 wt% (based on the total weight of the digestion solution) was added, and the mixture was allowed to digest for 4 h under the same conditions as described above. After digestion, the mixture was centrifuged, the enzyme was inactivated, filtered, and the calcium content and vitamin D3 content of the digestion solution were determined. The calcium absorption rate (%) = calcium content in the digestion solution / calcium content before digestion x 100%; the vitamin D3 absorption rate (%) = vitamin D3 content in the digestion solution / vitamin D3 content before digestion x 100%. The results are shown in Table 6.

[0125] Table 6: Results of calcium and vitamin D3 absorption rate testing

[0126]

[0127] In summary, the colloid composition, the amount and ratio of each component in the colloid, and the addition of caprylic acid and capric acid glycerides and the timing of the addition have a significant effect on the suspension stability, chemical stability and sensory effect of the high calcium content, high absorption type calcium vitamin D composition. Furthermore, the composition of the calcium source and the addition of caprylic acid and capric acid glycerides improve the absorption rate of calcium and vitamin D3.

[0128] The above detailed description is directed to one possible embodiment of the present application, and is not intended to limit the scope of the patent. Any equivalent implementation or modification that does not depart from the present application should be included within the scope of the technical solution of the present application.

Claims

1. A high calcium content, high absorbable calcium vitamin D composition characterized in that, The calcium vitamin D composition comprises the following components in 1000 parts by weight: 100-300 parts of calcium citrate, 60-130 parts of xylitol, 0.1-5 parts of calcium L-lactate, 0.001-0.01 parts of vitamin D3, 2-7 parts of a pH regulator, 5-17 parts of a colloid, 1-10 parts of capryl capryl glyceride, and 1-5 parts of vitamin C, with the balance being water; The colloid comprises gum tragacanth, gum arabic, and xanthan gum, and the mass ratio of the gum tragacanth, gum arabic, and xanthan gum is 1-4:5-8:1-3; The preparation method of the high-calcium-content and high-absorption calcium vitamin D composition comprises the following steps: (1) mixing vitamin D3 with part of capryl capryl glyceride, homogenizing to obtain a pre-emulsion; (2) dissolving vitamin C in water to obtain a vitamin C solution; (3) mixing calcium citrate and calcium L-lactate to obtain calcium powder, adding the calcium powder into water, and homogenizing to obtain a mixture A; (4) mixing a colloid and xylitol to obtain material a, adding the material a into water, and homogenizing to obtain a mixture B; (5) adding the pre-emulsion into the mixture B, and then adding the mixture A, the remaining capryl capryl glyceride, and the vitamin C solution into the mixture B to obtain a mixture C; (6) adding a pH regulator into the mixture C, supplementing the remaining water to a constant volume, adjusting the pH, sterilizing, and cooling to obtain the calcium vitamin D composition.

2. The high calcium content, highly absorbable calcium vitamin D composition according to claim 1, characterized in that, The calcium vitamin D composition further comprises at least one of isomalto-oligosaccharide and a flavoring substance.

3. The high calcium content, highly absorbable calcium vitamin D composition according to claim 2, wherein, The isomalto-oligosaccharide is used in an amount of 5-30 parts.

4. The high calcium content, highly absorbable calcium vitamin D composition according to claim 2, wherein, The flavoring substance comprises at least one of blood orange concentrate and camman orange concentrate.

5. The high calcium content, highly absorbable calcium vitamin D composition according to claim 1, wherein, The pH regulator comprises at least one of citric acid, malic acid, and lactic acid.

6. The high calcium content, highly absorbable calcium vitamin D composition according to claim 1, wherein, The pH of the calcium vitamin D composition is 4.0-5.

0.

7. A process for the preparation of a high calcium, highly absorbable calcium vitamin D composition according to any one of claims 1 to 6, characterized in that, The preparation method comprises the following steps: (1) mixing vitamin D3 with part of capryl capryl glyceride, homogenizing to obtain a pre-emulsion; (2) dissolving vitamin C in water to obtain a vitamin C solution; (3) mixing calcium citrate and calcium L-lactate to obtain calcium powder, adding the calcium powder into water, and homogenizing to obtain a mixture A; (4) mixing a colloid and xylitol, and adding or not adding isomalto-oligosaccharide to obtain material a, adding the material a into water, and homogenizing to obtain a mixture B; (5) adding the pre-emulsion into the mixture B, and then adding the mixture A, the remaining capryl capryl glyceride, and the vitamin C solution into the mixture B to obtain a mixture C; (6) adding or not adding a flavoring substance into the mixture C, adding a pH regulator into the mixture C, supplementing the remaining water to a constant volume, adjusting the pH, sterilizing, and cooling to obtain the calcium vitamin D composition.

8. The production method according to claim 7, characterized by, In step (1), the homogenization parameters are: a temperature of 40-50℃, a time of 8-15 min, and a pressure of 140-160 MPa; and / or the particle size of lipid droplets in the pre-emulsion is ≤0.5 μm; and / or the mass ratio of the part of capryl capryl glyceride to vitamin D3 is 300-500:1; and / or in step (2), the mass ratio of vitamin C to water is 1:2-5.

9. The preparation method according to claim 7, characterized in that, The mass ratio of calcium powder to water in step (3) is 1:1.3-3; and / or the temperature of the water in step (4) is 60-70℃, and the mass ratio of the material a to water is 1:1.3-3; and / or the pH regulator in step (6) is added in the form of a solution, and the mass ratio of the pH regulator to water in the solution is 1:2-5.

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