A visualizing needle assembly and system for stem cell injection

Abstract

The application discloses a visual puncture needle assembly and system for stem cell injection, and belongs to the technical field of stem cell treatment surgical instruments. The visual puncture needle system comprises a visual puncture needle assembly and a collection display system. The visual puncture needle assembly comprises a puncture needle, a visual sleeve, a plurality of camera probes and a plurality of laser ranging probes. The collection display system is in communication connection with the plurality of camera probes and the plurality of laser ranging probes. The collection display system is used for acquiring internal image picture information of a lesion cavity and displaying the internal image picture of the lesion cavity. Not only can the internal condition of the lesion cavity be observed, but also the position of the laser ranging probe in the lesion cavity can be adjusted. The collection display system is also used for acquiring internal size information of the lesion cavity, calculating the volume of the lesion cavity according to the internal size information of the lesion cavity, and then obtaining the dosage of stem cell injection, so that the purpose of precise treatment is achieved.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of stem cell treatment surgical instruments, and particularly relates to a visual puncture needle assembly and system for stem cell injection. BACKGROUND

[0002] Spinal cord injury and brain injury seriously affect the quality of life of patients, and the traditional treatment method has limited effect, stem cell treatment as a new treatment method brings new hope for patients with spinal cord injury and brain injury. Stem cell treatment has achieved certain results in preclinical research and part of clinical trials, and has great potential, such as promoting nerve regeneration and improving local microenvironment. However, in actual clinical application, how to accurately and effectively implant stem cells into the lesion capsule (target area) is a difficult problem.

[0003] At present, the common method for implanting stem cells into the lesion capsule is to implant through open spine or craniotomy surgery, but the open spine or craniotomy surgery has a large incision, the patient has a large amount of bleeding, and the postoperative discomfort is strong, and the operation is complex and difficult. SUMMARY

[0004] One of the purposes of the present application is to provide a visual puncture needle assembly and system for stem cell injection, which is used for injection and administration of the lesion capsule under local anesthesia, and has smaller surgical incision, less bleeding of the patient and weaker postoperative discomfort.

[0005] The second purpose of the present application is to provide a visual puncture needle assembly and system for stem cell injection, which collects internal image picture information of the lesion capsule through the camera probe, and displays the internal image picture of the lesion capsule through the collection and display system, so as to not only observe the internal condition of the lesion capsule, but also assist in adjusting the position of the laser ranging probe in the lesion capsule.

[0006] The third purpose of the present application is to provide a visual puncture needle assembly and system for stem cell injection, which can fit the lesion capsule as an ellipsoid and calculate the volume of the lesion capsule based on the multiple groups of data detected by the laser ranging probe, so as to obtain the dosage of stem cell injection and achieve the purpose of precise treatment.

[0007] In order to achieve the above purposes, the present application adopts the following technical solutions:

[0008] A visual puncture needle assembly for stem cell injection, comprising:

[0009] A puncture needle, the puncture needle comprising a puncture needle core and a puncture needle sleeve, for constructing a channel from outside to the lesion capsule;

[0010] A visualization sleeve, an outer diameter of the visualization sleeve is matched with an inner diameter of the puncture needle sleeve, a first limiter connected with the visualization sleeve is arranged on the visualization sleeve, and the first limiter is movable along an axial direction of the visualization sleeve;

[0011] A plurality of camera probes arranged at a front end of the visualization sleeve and used for collecting internal image information of the lesion cavity;

[0012] A plurality of laser ranging probes arranged at the front end of the visualization sleeve and used for detecting internal size information of the lesion cavity.

[0013] Further, the system further comprises:

[0014] A limiting injection needle, the limiting injection needle comprises a needle and a needle tube, the needle is fixed at one end of the needle tube and in communication with the needle tube, an outer diameter of the needle is matched with an inner diameter of the visualization sleeve, an injector connector is arranged at an end of the needle tube away from the needle, a second limiter connected with the needle tube is arranged on the needle tube, and the second limiter is movable along an axial direction of the needle tube.

[0015] Further, the system further comprises:

[0016] A flusher, the flusher comprises a flush tube and first and second branch tubes, the flush tube is a double-channel tube, an outer diameter of the flush tube is matched with an inner diameter of the visualization sleeve, the flush tube is made of soft material, and the first and second branch tubes are in communication with the double channels of the flush tube respectively.

[0017] Further, the first limiter and the visualization sleeve are in threaded connection.

[0018] Further, the second limiter and the needle tube are in threaded connection.

[0019] Further, a limiting scale is arranged on the needle tube.

[0020] A visualization puncture needle system for stem cell injection, comprising:

[0021] The visualization puncture needle assembly described above;

[0022] A collection and display system, the collection and display system is in communication connection with the plurality of camera probes and the plurality of laser ranging probes, the collection and display system is used for acquiring internal image information of the lesion cavity and displaying the internal image of the lesion cavity, the collection and display system is also used for acquiring internal size information of the lesion cavity and calculating a volume of the lesion cavity according to the internal size information of the lesion cavity, so as to determine a dosage of stem cell injection.

[0023] Further, the acquisition display system acquires internal size information of the lesion cavity, including the following steps:

[0024] S101, along the channel from outside to the lesion cavity, based on the internal image of the lesion cavity displayed by the acquisition display system, the visualization sleeve is placed into the target area in the lesion cavity, and then the first position limiter is moved to abut against the puncture needle sleeve;

[0025] S102, the visualization sleeve is rotated, and before the visualization sleeve is rotated, the acquisition display system acquires the straight line distance D from each laser ranging probe to the corresponding position on the inner wall of the lesion cavity, to obtain a group of data in the internal size information of the lesion cavity;

[0026] S103, the visualization sleeve is rotated multiple times, and the acquisition display system acquires multiple groups of data according to S102 to form the internal size information of the lesion cavity.

[0027] Further, in S102, the calculation formula of the straight line distance D from the laser ranging probe to the corresponding position on the inner wall of the lesion cavity is as follows:

[0028] D=Bf / x, wherein B is the baseline distance of the transmitter and receiver in the laser ranging probe, f is the focal length of the optical lens in the receiver of the laser ranging probe, and x is the offset of the light spot in the receiver of the laser ranging probe.

[0029] Further, the acquisition display system calculates the volume of the lesion cavity according to the internal size information of the lesion cavity, including the following steps:

[0030] S201, based on a modeling tool, the lesion cavity is fitted as an ellipsoid by the internal size information of the lesion cavity composed of multiple groups of data, and the long axis a, the medium axis b and the short axis c of the lesion cavity are obtained;

[0031] S202, based on the long axis a, the medium axis b and the short axis c of the lesion cavity, the volume V of the lesion cavity is calculated according to the formula V=π / 6abc.

[0032] The present application has the following advantages:

[0033] 1. The application provides a visual puncture needle assembly and system for stem cell injection, which is used for injection and administration of lesions in a local anesthesia state, has smaller surgical wound, less bleeding of patients and weaker postoperative discomfort, and simultaneously, a camera probe and a laser ranging probe are designed at the front end of the visualization sleeve, and the camera probe and the laser ranging probe are both in communication connection with the collection and display system, on the one hand, the camera probe collects internal image picture information of the lesion cavity, and then the internal image picture of the lesion cavity is displayed through the collection and display system, so that the internal condition of the lesion cavity can be observed, and the position of the laser ranging probe in the lesion cavity can be adjusted, on the other hand, based on a plurality of data detected by the laser ranging probe, the collection and display system can fit the lesion cavity as an ellipsoid and calculate the volume of the lesion cavity, so as to obtain the drug dosage of stem cell injection, and the purpose of precise treatment is achieved.

[0034] 2. The application provides a visual puncture needle assembly and system for stem cell injection, wherein the second limiter in the limiting injection needle head can move along the axial direction of the needle tube, so that the needle insertion length can be accurately limited to avoid too deep or too shallow needle insertion, and simultaneously, the needle head of the limiting injection needle head is inserted after passing through the visualization sleeve, and the whole process of needle insertion and injection can be observed based on the camera probe, so that the purpose of real-time monitoring is achieved.

[0035] 3. The application provides a visual puncture needle assembly and system for stem cell injection, wherein the internal part of the lesion cavity can be pretreated through the flusher before stem cell injection, and simultaneously, the flush tube in the flusher is inserted after passing through the visualization sleeve, and the whole process of flushing can be observed based on the camera probe, so that the purpose of real-time monitoring is achieved. BRIEF DESCRIPTION OF DRAWINGS

[0036] Figure 1 It is a structural schematic view of the visual puncture needle assembly for stem cell injection.

[0037] Figure 2 It is a combination schematic view of the visual puncture needle assembly for stem cell injection (puncture needle sleeve and visualization sleeve).

[0038] Figure 3 It is a combination schematic view of the visual puncture needle assembly for stem cell injection (puncture needle sleeve, visualization sleeve and limiting injection needle head).

[0039] Figure 4 It is a structural schematic view of the flusher in the visual puncture needle assembly for stem cell injection.

[0040] Figure 5 It is a combination schematic view of the visual puncture needle assembly for stem cell injection (puncture needle sleeve, visualization sleeve and flusher).

[0041] Figure 6 A use state diagram of a visual puncture needle assembly for stem cell injection (for stem cell injection of the brain).

[0042] Figure 7 A use state diagram of a visual puncture needle assembly for stem cell injection (for stem cell injection of the brain).

[0043] Legend: 1, puncture needle sleeve, 2, puncture needle core, 3, visualization sleeve, 4, first limiter, 5, needle, 6, needle tube, 7, syringe connector, 8, second limiter, 9, flushing tube, 10, first branch tube, 11, second branch tube. DETAILED DESCRIPTION

[0044] In order to make the purpose, technical scheme and advantages of the present application more clear, the present application is further described in detail below in combination with the drawings and examples. It should be understood that the specific examples described herein are only used to explain the present application and do not limit the present application.

[0045] Example 1:

[0046] Please refer to Figure 1 , 2 , a visual puncture needle system for stem cell injection, which comprises a visual puncture needle assembly and a collection display system.

[0047] The visual puncture needle assembly comprises:

[0048] The puncture needle comprises a puncture needle core 2 and a puncture needle sleeve 1, which are used to form a channel from outside to the lesion cavity (after the puncture needle completes puncture, the puncture needle core 2 is pulled out, thereby forming a channel from outside to the lesion cavity);

[0049] The visualization sleeve 3 has an outer diameter matched with the inner diameter of the puncture needle sleeve 1, and the visualization sleeve 3 is provided with a first limiter 4 connected thereto, and the first limiter 4 can move along the axial direction of the visualization sleeve 3;

[0050] A plurality of miniature camera probes are arranged at the front end (end face and side face) of the visualization sleeve 3, which are used to collect internal image information of the lesion cavity;

[0051] A plurality of miniature laser ranging probes are arranged at the front end (end face and side face) of the visualization sleeve 3, which are used to detect internal size information of the lesion cavity.

[0052] In this embodiment, the first limiter 4 and the visualization sleeve 3 are threadedly connected.

[0053] The acquisition and display system is in communication connection with the plurality of camera probes and the plurality of laser ranging probes, and is used to acquire internal image picture information of the lesion cavity and display the internal image picture of the lesion cavity, and is also used to acquire internal size information of the lesion cavity, and calculate the volume of the lesion cavity according to the internal size information of the lesion cavity, so as to determine the dosage of stem cell injection.

[0054] Specifically, the acquisition and display system acquires the internal size information of the lesion cavity, including the following steps:

[0055] S101, along the channel from outside to the lesion cavity, based on the internal image picture of the lesion cavity displayed by the acquisition and display system, the visualization sleeve 3 is placed into the target area in the lesion cavity, the target area refers to the central position or the position near the center of the lesion cavity, and then the first position limiter 4 is moved to abut against the puncture needle sleeve 1;

[0056] S102, the visualization sleeve 3 is rotated, and before the visualization sleeve 3 is rotated, the acquisition and display system acquires the straight line distance D from each laser ranging probe to the corresponding position on the inner wall of the lesion cavity, to obtain a group of data in the internal size information of the lesion cavity;

[0057] S103, the visualization sleeve 3 is rotated multiple times, and the acquisition and display system acquires multiple groups of data according to S102 to form the internal size information of the lesion cavity.

[0058] In S102, the calculation formula of the straight line distance D from the laser ranging probe to the corresponding position on the inner wall of the lesion cavity is as follows:

[0059] D=Bf / x, wherein B is the baseline distance of the transmitter and the receiver in the laser ranging probe, f is the focal length of the optical lens in the receiver of the laser ranging probe, and x is the offset of the light spot in the receiver of the laser ranging probe.

[0060] More specifically, the acquisition and display system calculates the volume of the lesion cavity according to the internal size information of the lesion cavity, including the following steps:

[0061] S201, based on the modeling tool, the lesion cavity is fitted as an ellipsoid by the internal size information of the lesion cavity composed of multiple groups of data, and the long axis a, the middle axis b and the short axis c of the lesion cavity are obtained;

[0062] S202, based on the long axis a, the middle axis b and the short axis c of the lesion cavity, the volume V of the lesion cavity is calculated according to the formula V=π / 6abc.

[0063] In this embodiment, the acquisition and display system includes a data acquisition unit, a PC end (including a display) and the like; the camera probe and the laser ranging probe are in communication connection with the acquisition and display system through a wire harness.

[0064] The internal size information of the lesion cavity obtained by the acquisition and display system is described below in combination with data:

[0065] The acquisition and display system obtains the straight-line distance D from each laser ranging probe to the corresponding position on the inner wall of the lesion cavity, for example:

[0066] When B is 1 mm, f is 800 px / mm, and x is 40 px, D is calculated to be 20 mm;

[0067] The visual sleeve 3 is rotated multiple times, and the acquisition and display system obtains multiple sets of data to form the internal size information of the lesion cavity, for example:

[0068] The visual sleeve 3 is rotated 11 times, each time by about 30°, to obtain 12 sets of data;

[0069] The acquisition and display system calculates the volume of the lesion cavity based on the internal size information of the lesion cavity, for example:

[0070] Based on MATLAB software, a is fitted to be 80 mm, b is fitted to be 12 mm, and c is fitted to be 10 mm;

[0071] The volume V of the lesion cavity is calculated to be π / 6abc = π / 6·80·12·10 ≈ 5024 mm 3 ≈ 5 cm 3 .

[0072] According to the above design, the lesion cavity is injected with medicine under local anesthesia, the surgical wound is smaller, the amount of bleeding of the patient is less, and the postoperative discomfort is weaker. At the same time, the internal image information of the lesion cavity is collected by the camera probe, and the internal image of the lesion cavity is displayed by the acquisition and display system. Not only can the internal situation of the lesion cavity be observed, but also the position of the laser ranging probe in the lesion cavity can be adjusted. Based on the multiple sets of data detected by the laser ranging probe, the acquisition and display system can fit the lesion cavity as an ellipsoid and calculate the volume of the lesion cavity, and then the amount of stem cell injection is obtained, so as to achieve the purpose of precise treatment.

[0073] Example 2:

[0074] Please refer to Figure 1 , 3As shown, on the basis of Embodiment 1, the visual puncture needle assembly further comprises a limiting injection needle, the limiting injection needle comprises a needle 5 (with an opening at the front end) and a needle tube 6, the needle 5 is fixed at one end of the needle tube 6 and communicates with the needle tube 6, and the outer diameter of the needle 5 is matched with the inner diameter of the visual sleeve 3, the end of the needle tube 6 away from the needle 5 is provided with a syringe connector 7, and the second limiter 8 connected with the needle tube 6 is movably arranged on the needle tube 6. In use, the syringe with stem cell suspension is communicated with the limiting injection needle through the syringe connector 7.

[0075] Preferably, the needle tube 6 is provided with a limiting scale to achieve the purpose of accurately adjusting the second limiter 8.

[0076] In this embodiment, the second limiter 8 and the needle tube 6 are threadedly connected.

[0077] Since the needle 5 and the needle tube 6 in the limiting injection needle will remain stem cell suspension, when preparing stem cell suspension by the syringe, the dose of stem cell injection should be at least the sum of the volume of the lesion cavity and the volume of the needle 5 and the needle tube 6 (known).

[0078] According to the above design, the second limiter 8 in the limiting injection needle can move along the axial direction of the needle tube 6, so that the needle insertion length can be accurately limited to avoid too deep or too shallow needle insertion. At the same time, the needle 5 in the limiting injection needle is inserted after passing through the visual sleeve 3, and the whole process of needle insertion and injection can be observed based on the camera probe, so as to achieve the purpose of real-time monitoring.

[0079] In addition, it should be further pointed out that the visual puncture needle assembly can be used for stem cell injection of the spinal cord, such as Figure 6 As shown, and can also be used for stem cell injection of the brain, such as Figure 7 As shown.

[0080] Embodiment 3:

[0081] Please refer to Figure 1 , 4 and 5, on the basis of Embodiment 1, the visual puncture needle assembly further comprises a flusher, the flusher comprises a flush pipe 9 and first and second branch pipes 10 and 11, the flush pipe 9 is a double-channel pipe, the outer diameter of the flush pipe 9 is matched with the inner diameter of the visual sleeve 3, and the flush pipe 9 is made of soft material, and the first and second branch pipes 10 and 11 are respectively communicated with the double channels of the flush pipe 9. In use, the syringe with flushing liquid is communicated with the first branch pipe 10, and the flushed liquid is discharged through the second branch pipe 11.

[0082] According to the above design, before the stem cell injection, the inside of the lesion cavity can be pretreated through the flusher, meanwhile, the flush tube 9 in the flusher is inserted into the needle after passing through the visualization sleeve 3, the whole flush process can be observed based on the camera probe, and the real-time monitoring purpose is achieved.

[0083] The present application is not limited to the above specific embodiments, and those skilled in the art can implement the present application by using other various specific embodiments according to the disclosed content of the present application, therefore, any design falling into the protection scope of the present application by using the design structure and idea of the present application and making some simple changes or modifications is also within the protection scope of the present application.

Claims

1. A visualizing puncture needle system for stem cell injection, characterized by: The utility model relates to a kind of medical device for stem cell injection, including: Puncture needle, which includes a puncture needle needle core and a puncture needle sleeve, is used to construct a channel from outside to lesion cavity; A visualization sleeve with an outer diameter matching the inner diameter of the puncture needle sleeve, the visualization sleeve is provided with a first limiter connected thereto, and the first limiter can move axially along the visualization sleeve; A plurality of camera probes are provided at the front end of the visualization sleeve for collecting internal image information of the lesion cavity; A plurality of laser ranging probes are provided at the front end of the visualization sleeve for detecting internal size information of the lesion cavity; A collection and display system is in communication with the plurality of camera probes and the plurality of laser ranging probes, the collection and display system is used to obtain internal image information of the lesion cavity and display the internal image of the lesion cavity, and the collection and display system is also used to obtain internal size information of the lesion cavity and calculate the volume of the lesion cavity according to the internal size information of the lesion cavity to determine the dosage of stem cell injection; The collection and display system obtains internal size information of the lesion cavity, including the following steps: S101, along the channel from outside to the lesion cavity, based on the internal image of the lesion cavity displayed by the collection and display system, place the visualization sleeve into the target area inside the lesion cavity, then move the first limiter to abut against the puncture needle sleeve; S102, rotate the visualization sleeve, and before rotating the visualization sleeve, the collection and display system obtains the straight-line distance D from each laser ranging probe to the corresponding position on the inner wall of the lesion cavity, obtaining a set of data of the internal size information of the lesion cavity; S103, rotate the visualization sleeve multiple times, and the collection and display system obtains multiple sets of data according to S102 to form the internal size information of the lesion cavity; The collection and display system calculates the volume of the lesion cavity according to the internal size information of the lesion cavity, including the following steps: S201, based on a modeling tool, fit the lesion cavity as an ellipsoid by the internal size information of the lesion cavity composed of multiple sets of data, and obtain the major axis a, the middle axis b, and the minor axis c of the lesion cavity; S202, based on the major axis a, the middle axis b, and the minor axis c of the lesion cavity, calculate the volume V of the lesion cavity according to the formula V=π / 6abc.

2. The visualizing needle system for stem cell injection according to claim 1, wherein: In S102, the calculation formula of the straight-line distance D from the laser ranging probe to the corresponding position on the inner wall of the lesion cavity is as follows: D=Bf / x, where B is the baseline distance between the transmitter and receiver in the laser ranging probe, f is the focal length of the optical lens in the receiver of the laser ranging probe, and x is the offset of the light spot in the receiver of the laser ranging probe.

3. The visualizing biopsy needle system for stem cell injection according to claim 1, wherein: Further comprising: The limiting injection needle comprises a needle and a needle tube, the needle is fixed at one end of the needle tube and communicates with the needle tube, the outer diameter of the needle is matched with the inner diameter of the visualization sleeve, the end of the needle tube away from the needle is provided with a syringe connector, the second limiter connected with the needle tube is movably arranged along the axial direction of the needle tube.

4. The visualizing biopsy needle system for stem cell injection of claim 1, wherein: Further comprising: The flusher comprises a flush pipe and first and second branch pipes, the flush pipe is a double-channel pipe, the outer diameter of the flush pipe is matched with the inner diameter of the visualization sleeve, the flush pipe is made of soft material, and the first and second branch pipes respectively communicate with the double channels of the flush pipe.

5. The visualized needle system for stem cell injection according to any one of claims 1, 3, 4, wherein: The first limiter is in threaded connection with the visualization sleeve.

6. The visualizing biopsy needle system for stem cell injection according to claim 3, wherein: The second limiter is in threaded connection with the needle tube.

7. The visualized needle system for stem cell injection according to claim 3 or 6, wherein: The needle tube is provided with a limiting scale.

Images