Traditional Chinese medicine composition for treating various difficult miscellaneous diseases and preparation method and application thereof

Abstract

The invention belongs to the field of traditional Chinese medicines, and relates to a traditional Chinese medicine composition for treating various difficult miscellaneous diseases, and a preparation method and application thereof. The traditional Chinese medicine composition comprises the following components in parts by weight: folium artemisiae argyi, frankincense, rhizoma acori graminei, saponin, fructus aurantii, ligusticum wallichii, cassia twig, eucommia ulmoides, scorpio, radix angelicae, asarum, rosin, realgar, radix angelicae pubescentis, loofah sponge, clove, safflower carthamus, dandelion, oldenlandia diffusa, sculellaria barbata, rose, Chinese lobelia, radix paeoniae rubra, bamboo shavings, radix clematidis, perilla leaf, radix bupleuri and rhizoma corydalis. Through compatibility and component optimization of various traditional Chinese medicinal materials, the safety, the drug effect exertion and the sustainability are remarkably improved.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine technology, specifically to a traditional Chinese medicine composition for treating various intractable diseases, its preparation method, and its application. Background Technology

[0002] Traditional Chinese medicine (TCM) mainly consists of plant-based medicines, such as roots, stems, leaves, and fruits; animal-based medicines, such as internal organs, skin, bones, and viscera; and mineral-based medicines. Because plant-based medicines constitute the majority of TCM, it is also called Chinese herbal medicine. Around 5,000 kinds of TCM are used throughout China, and countless prescriptions are formed by combining various medicinal materials. After thousands of years of research, it has developed into an independent science—herbal medicine.

[0003] With industrial development and environmental pollution, more and more people are suffering from arthralgia, atrophy, epilepsy, asthma, tumors, and other ailments. The medications used to treat these conditions are generally Western medicines, but these have significant side effects and are not suitable for long-term use. Therefore, there is a need to develop a traditional Chinese medicine formula that can treat various intractable diseases such as arthralgia, atrophy, epilepsy, asthma, and tumors.

[0004] To address the aforementioned issues, patent application CN106924576A provides a formula capable of treating various intractable diseases. Its components include mugwort, sulfur, frankincense, musk, soapberry, immature bitter orange peel, chuanxiong rhizome, cinnamon twig, eucommia bark, scorpion, angelica root, asarum, rosin, realgar, angelica pubescens root, pangolin scales, clove, safflower, dandelion, oldenlandia diffusa, scutellaria barbata, rose, lobelia chinensis, red peony root, bamboo shavings, clematis root, perilla leaf, bupleurum root, and corydalis rhizome.

[0005] However, the above-mentioned solution still has some obvious drawbacks. First, the formula contains sulfur, which may produce toxic and irritating substances during the burning process of moxibustion sticks, posing a potential threat to human health and posing a safety hazard.

[0006] Secondly, the efficacy of this formula in practical applications is still insufficient, especially when used as moxibustion sticks. Its drug penetration is weak, making it difficult to deliver the effective ingredients quickly and deeply to the lesion site, resulting in a longer treatment time and affecting the overall efficacy and the patient's treatment experience.

[0007] In addition, the formula contains pangolin, which is a protected rare wild animal. Its use not only faces high costs, but also involves ethical controversies related to animal protection.

[0008] Therefore, there is a need for a formula that is safer, has stronger drug penetration, and is more ethically compliant for treating a variety of intractable diseases. Summary of the Invention

[0009] (a) Technical problems to be solved

[0010] To address the safety concerns, insufficient drug penetration, high costs, and ethical controversies related to animal protection in existing formulations for treating various intractable diseases, this invention provides a traditional Chinese medicine composition for treating various intractable diseases, its preparation method, and its application.

[0011] (II) Technical Solution

[0012] To achieve the above objectives, the main technical solutions adopted by the present invention include:

[0013] In a first aspect, the present invention provides a traditional Chinese medicine composition for treating various intractable diseases, comprising, by weight, 30-150 parts of Artemisia argyi, 3-15 parts of frankincense, 8-12 parts of Acorus tatarinowii, 3-15 parts of Gleditsia sinensis, 5-30 parts of Citrus aurantium, 5-20 parts of Ligusticum chuanxiong, 5-20 parts of Cinnamomum cassia, 5-20 parts of Eucommia ulmoides, 1-3 parts of Buthus martensii, 3-15 parts of Angelica dahurica, 1-3 parts of Asarum heterotropoides, and 1-3 parts of rosin. Realgar 1-3 parts, Angelica pubescens 3-15 parts, Luffa sponge 1-3 parts, Clove 3-15 parts, Safflower 3-15 parts, Dandelion 3-15 parts, Hedyotis diffusa 3-15 parts, Scutellaria barbata 3-15 parts, Rose 3-15 parts, Lobelia chinensis 3-15 parts, Red peony 3-15 parts, Bamboo shavings 5-12 parts, Clematis chinensis 5-12 parts, Perilla frutescens 3-5 parts, Bupleurum chinense 5-12 parts, Corydalis yanhusuo 5-12 parts.

[0014] The traditional Chinese medicine composition for treating various intractable diseases as described above preferably has the following weight ratio: (40-130):(5-12):(9-11) based on the weight of Artemisia argyi, frankincense and Acorus tatarinowii.

[0015] The traditional Chinese medicine composition for treating various intractable diseases as described above preferably has the following weight ratios: (5-12):(8-25):(7-18):(7-18):(7-18) based on the weight of the following ingredients: Gleditsia sinensis, Citrus aurantium, Ligusticum chuanxiong, Cinnamomum cassia and Eucommia ulmoides.

[0016] The traditional Chinese medicine composition for treating various intractable diseases as described above preferably has the following weight ratio: (1.5-2.5):(5-12):(1.5-2.5):(1.5-2.5).

[0017] The traditional Chinese medicine composition for treating various intractable diseases as described above preferably has the following weight ratio: realgar, angelica pubescens, loofah sponge and cloves: (1.5-2.5):(5-12):(1.5-2.5):(5-12).

[0018] The traditional Chinese medicine composition for treating various intractable diseases as described above, preferably, has the following mass ratio by weight: safflower, dandelion, oldenlandia diffusa, scutellaria barbata, rose, lobelia chinensis and red peony root (5-12):(5-12):(5-12):(5-12):(5-12):(5-12):(5-12):(5-12):(5-12):(5-12).

[0019] The traditional Chinese medicine composition for treating various intractable diseases as described above preferably has the following mass ratio by weight: (7-10):(7-10):(3.5-4.5):(7-10):(7-10).

[0020] The traditional Chinese medicine composition for treating various intractable diseases, as described above, preferably comprises, by weight, 40-130 parts of Artemisia argyi, 5-12 parts of frankincense, 9-11 parts of Acorus tatarinowii, 5-12 parts of Gleditsia sinensis, 8-25 parts of Citrus aurantium, 7-18 parts of Ligusticum chuanxiong, 7-18 parts of Cinnamomum cassia, 7-18 parts of Eucommia ulmoides, 1.5-2.5 parts of Buthus martensii, 5-12 parts of Angelica dahurica, 1.5-2.5 parts of Asarum heterotropoides, 1.5-2.5 parts of rosin, and male... Yellow 1.5-2.5 parts, Angelica pubescens 5-12 parts, Luffa sponge 1.5-2.5 parts, Syzygium aromaticum 5-12 parts, Carthamus tinctorius 5-12 parts, Taraxacum mongolicum 5-12 parts, Hedyotis diffusa 5-12 parts, Scutellaria barbata 5-12 parts, Rosa rugosa 5-12 parts, Lobelia chinensis 5-12 parts, Paeonia lactiflora 5-12 parts, Bambusa textilis 7-10 parts, Clematis chinensis 7-10 parts, Perilla frutescens 3.5-4.5 parts, Bupleurum chinense 7-10 parts, Corydalis yanhusuo 7-10 parts.

[0021] Secondly, the present invention provides a method for preparing the above-mentioned traditional Chinese medicine composition for treating various intractable diseases, comprising the following steps:

[0022] S1: Weigh out the following ingredients according to the specified proportions: Artemisia argyi, frankincense, Acorus tatarinowii, Gleditsia sinensis, Citrus aurantium, Ligusticum chuanxiong, Cinnamomum cassia, Eucommia ulmoides, Buthus martensii, Angelica dahurica, Asarum heterotropoides, Rosin, Realgar, Angelica pubescens, Luffa cylindrica, Clove, Carthamus tinctorius, Taraxacum mongolicum, Hedyotis diffusa, Scutellaria barbata, Rosa rugosa, Lobelia chinensis, Paeonia lactiflora, Bambusa textilis, Clematis chinensis, Perilla frutescens, Bupleurum chinense, and Corydalis yanhusuo.

[0023] S2: Pulverize the medicinal materials obtained in step S1, mix them evenly, and pass them through a 30-40 mesh sieve to obtain a traditional Chinese medicine composition.

[0024] Thirdly, the present invention also provides the application of the above-mentioned traditional Chinese medicine composition or the traditional Chinese medicine composition prepared by the above-mentioned preparation method in moxibustion sticks or medicinal bath powder.

[0025] As described above, preferably, the preparation method of the moxibustion stick is as follows: add water or binder to the traditional Chinese medicine composition, stir evenly, add the mixture into the moxibustion stick mold, and obtain the moxibustion stick after solidification;

[0026] The application method of the medicinal bath powder is as follows: add water to the traditional Chinese medicine composition, heat at 80-90℃ for 2-4 hours, filter to obtain the washing solution; the mass ratio of the traditional Chinese medicine composition to sterile water is 1:20-1:50.

[0027] (III) Beneficial Effects

[0028] This invention significantly improves safety, efficacy, and sustainability by combining and optimizing various traditional Chinese medicinal materials. Through the synergistic effect of multiple components and the rational control of their content, the formula offers advantages such as ease of use, strong permeability, material conservation, and high medicinal value. It can directly target the lesion, treating various diseases including arthritis, atrophy, epilepsy, asthma, and tumors, and significantly improving symptoms of many intractable diseases. Specifically, this invention eliminates the sulfur component, which may pose safety hazards in traditional formulas, avoiding the risk of producing toxic and harmful substances during combustion, reducing the risk of irritation to the respiratory tract and skin mucous membranes, and improving safety and environmental friendliness.

[0029] This invention also uses Acorus tatarinowii to replace musk in traditional formulas. Compared to musk, in the herbal composition of this invention, Acorus tatarinowii and frankincense have a good synergistic effect, which can effectively enhance the penetration of the drug, allowing the efficacy to act on the lesion site more quickly, shortening the treatment time, and improving the efficiency of clinical application and patient acceptance. In addition, by using the more inexpensive and readily available Acorus tatarinowii to replace natural musk, not only can production costs be significantly reduced, but the supply bottleneck caused by the scarcity, low yield and high price of natural musk resources can also be effectively overcome. This greatly improves the feasibility of large-scale production and clinical application of the herbal composition, ensuring the sustainability and economy of the drug source.

[0030] This invention also uses loofah sponge instead of pangolin scales, resolving the ethical controversies arising from the utilization of rare animal resources, aligning with modern ecological protection principles. Furthermore, loofah sponge is inexpensive, significantly reducing the difficulty and economic burden of obtaining raw materials while ensuring efficacy. The introduction of loofah sponge not only resolves ethical issues, but its porous fiber structure also optimizes the combustion characteristics of the herbal composition used as moxibustion sticks. Compared to pangolin scales, loofah sponge burns more evenly, generating stable and prolonged heat while reducing ash residue, making it more suitable for moxibustion stick applications and contributing to the stable release of medicinal effects. Detailed Implementation

[0031] To better explain and facilitate understanding of the present invention, the present invention will be described in detail below with reference to specific embodiments.

[0032] This invention provides a traditional Chinese medicine composition for treating various intractable diseases, comprising, by weight, 30-150 parts of Artemisia argyi, 3-15 parts of frankincense, 8-12 parts of Acorus tatarinowii, 3-15 parts of Gleditsia sinensis, 5-30 parts of Citrus aurantium, 5-20 parts of Ligusticum chuanxiong, 5-20 parts of Cinnamomum cassia, 5-20 parts of Eucommia ulmoides, 1-3 parts of Buthus martensii, 3-15 parts of Angelica dahurica, 1-3 parts of Asarum heterotropoides, 1-3 parts of rosin, and realgar. 1-3 parts, Angelica pubescens 3-15 parts, Luffa sponge 1-3 parts, Clove 3-15 parts, Safflower 3-15 parts, Dandelion 3-15 parts, Hedyotis diffusa 3-15 parts, Scutellaria barbata 3-15 parts, Rose 3-15 parts, Lobelia chinensis 3-15 parts, Paeonia lactiflora 3-15 parts, Bambusa textilis 5-12 parts, Clematis chinensis 5-12 parts, Perilla frutescens 3-5 parts, Bupleurum chinense 5-12 parts, Corydalis yanhusuo 5-12 parts.

[0033] This invention significantly improves safety, efficacy, and sustainability by combining and optimizing various Chinese medicinal herbs. Through the synergistic effect of multiple components and the rational control of the content of each component, the formula has the advantages of being easy to use, highly permeable, material-saving, and having high medicinal value. It can directly reach the lesion and treat a variety of diseases such as arthralgia, atrophy, epilepsy, asthma, and tumors.

[0034] Specifically, this invention eliminates the sulfur component, which may pose safety hazards in traditional formulations, thus avoiding the risk of producing toxic and harmful substances during combustion, reducing the risk of irritation to the respiratory tract and skin mucous membranes, and improving safety and environmental friendliness. Furthermore, even though this invention removes the sulfur component, realgar is retained in the formulation. Since sulfur and realgar have relatively similar effects, the insecticidal and bactericidal effects of the traditional Chinese medicine composition are still preserved and unaffected.

[0035] This invention also uses Acorus tatarinowii to replace musk in traditional formulas. In the herbal composition of this invention, Acorus tatarinowii and frankincense have a good synergistic effect, which can effectively enhance the penetration of the drug, allowing the efficacy to act on the lesion site more quickly, shortening the treatment time, and improving the efficiency of clinical application and patient acceptance. In addition, by using the more inexpensive and readily available Acorus tatarinowii to replace natural musk, not only can production costs be significantly reduced, but the supply bottleneck caused by the scarcity, low yield and high price of natural musk resources can also be effectively overcome. This greatly improves the feasibility of large-scale production and clinical application of the herbal composition, ensuring the sustainability and economy of the drug source.

[0036] Although both Acorus tatarinowii and frankincense are common Chinese medicinal herbs, their medicinal properties and indications differ. Those skilled in the art generally believe that their mechanisms of action are different and unlikely to produce a synergistic effect. However, through long-term research and practice, the researchers of this invention have discovered that, under the specific prescription and proportions of this invention, Acorus tatarinowii and frankincense exhibit an unexpected synergistic effect. This discovery breaks through the conventional understanding of traditional Chinese medicine compatibility.

[0037] This invention also uses loofah sponge instead of pangolin scales, resolving the ethical controversies arising from the utilization of rare animal resources, aligning with modern ecological protection principles. Furthermore, loofah sponge is inexpensive, significantly reducing the difficulty and economic burden of obtaining raw materials while ensuring efficacy. The introduction of loofah sponge not only resolves ethical issues, but its porous fiber structure also optimizes the combustion characteristics of the herbal composition used as moxibustion sticks. Compared to pangolin scales, loofah sponge burns more evenly, generating stable and prolonged heat while reducing ash residue, making it more suitable for moxibustion stick applications and contributing to the stable release of medicinal effects.

[0038] The detailed pharmacological properties of each raw material component in this invention are as follows:

[0039] Artemisia argyi: Its medicinal properties are pungent, bitter, and warm; it is slightly toxic and enters the liver, spleen, and kidney meridians. It has the effects of warming the meridians and dispelling cold, expelling parasites and killing bacteria, soothing the meridians and promoting blood circulation, aiding digestion, and regulating menstruation. It is widely used in diseases caused by cold pathogens.

[0040] Frankincense: It is the oleoresin exuded from the bark of the small shrub Boswellia carterii and related plants of the Burseraceae family. It has the effects of promoting blood circulation and relieving pain, reducing swelling and promoting tissue regeneration, and regulating menstruation. It is suitable for rheumatic pain, abdominal pain, traumatic injuries, carbuncles and boils, urticaria and itchy skin diseases.

[0041] Acorus tatarinowii: It is warm in nature, pungent and bitter in taste, and enters the heart and stomach meridians. It has the effects of opening the orifices and refreshing the mind, refreshing the mind and improving intelligence, resolving dampness and harmonizing the stomach, regulating qi and relieving bloating, dispelling wind and unblocking the meridians, and relieving pain. It is suitable for symptoms such as delirium, epilepsy, forgetfulness, insomnia and dementia caused by phlegm obstructing the heart orifices, abdominal distension, loss of appetite and diarrhea caused by dampness obstructing the middle jiao, wind-cold-dampness bi syndrome, headache and toothache.

[0042] In this invention, the combination of Acorus tatarinowii and frankincense enhances the effects of clearing the meridians and activating collaterals, refreshing the mind and opening the orifices, promoting blood circulation and removing blood stasis, reducing swelling and relieving pain, dispelling wind and dampness, warming the meridians and dispelling cold, dispersing goiter and tumors, and supporting the body's resistance and eliminating pathogenic factors. It is characterized by its potent medicinal effect, strong heat, strong penetration, and wide applicability in moxibustion. Compared to musk, Acorus tatarinowii can also be used to treat diseases caused by cold and heat pathogens, making it more widely applicable, easier to obtain, and lower in cost. Compared to musk, Acorus tatarinowii and frankincense have a better synergistic effect; they can interact to improve drug penetration, enhance efficacy, and shorten treatment time.

[0043] Soapberry: Also known as soapberry, it has the effects of expectorant and antitussive, opening the orifices and clearing blockages, killing parasites and dispersing nodules. It is often used to treat stubborn phlegm obstructing the lungs, cough with excessive phlegm, stroke, epilepsy, sore throat with phlegm obstruction, intestinal bleeding, carbuncles, scabies and other diseases.

[0044] Citrus aurantium: The mature fruit of Citrus medica, Citrus aurantium, etc. After drying, it can be used as medicine. It has the effects of regulating qi, relieving chest tightness, promoting digestion and relieving bloating. It is often used to treat symptoms such as chest and rib stagnation, abdominal distension and pain, indigestion, phlegm retention, and organ prolapse.

[0045] Chuanxiong (Ligusticum striatum): It has the effects of promoting blood circulation, regulating qi, dispelling wind and relieving pain. It is often used to treat pain syndromes, headaches, and rheumatic pain caused by blood stasis and qi stagnation.

[0046] Cinnamon twig: It has the effects of inducing sweating and relieving muscle tension, warming and unblocking the meridians, and assisting yang and promoting qi circulation. It is often used to treat colds caused by wind and cold, abdominal pain due to cold, amenorrhea due to blood stasis, joint pain, phlegm retention and edema, palpitations and abdominal distension, etc.

[0047] Eucommia ulmoides: It has the effects of tonifying the liver and kidneys, strengthening tendons and bones, and calming the fetus. It is often used to treat symptoms such as kidney deficiency and lower back pain, weakness of tendons and bones, bleeding during pregnancy, and threatened miscarriage.

[0048] Whole scorpion: It has the effects of calming wind and relieving spasms, clearing the meridians and relieving pain, and attacking toxins and dispersing nodules. It is often used to treat diseases such as internal wind in the liver, spasms and convulsions, infantile convulsions, facial paralysis due to stroke, hemiplegia, tetanus, stubborn rheumatism, migraine, carbuncles and boils, scrofula and tuberculosis.

[0049] Angelica dahurica: It has the effects of relieving exterior syndromes and dispelling cold, dispelling wind and relieving pain, clearing nasal passages, drying dampness and stopping leukorrhea, and reducing swelling and draining pus. It is often used to treat colds caused by wind and cold, headaches, toothaches, sinusitis, leukorrhea, carbuncles and boils.

[0050] Asarum: It has the effects of relieving exterior syndromes and dispelling cold, dispelling wind and relieving pain, clearing the orifices, warming the lungs and resolving phlegm. It is often used to treat colds caused by wind and cold, headaches, toothaches, rheumatic pain, sinusitis, cough and asthma due to lung cold, and other diseases.

[0051] Rosin: It has the effects of dispelling wind and dampness, draining pus and removing toxins, promoting tissue regeneration and relieving pain. It is often used to treat carbuncles, malignant sores, scrofula, fistulas, scabies, alopecia areata, sprains, rheumatic pain, thromboangiitis obliterans and other diseases.

[0052] Realgar: It has the effects of detoxifying, killing parasites, drying dampness and eliminating phlegm, and treating malaria. It is often used to treat boils, carbuncles, snake and insect bites, abdominal pain due to intestinal parasites, epilepsy, malaria, and other diseases.

[0053] Angelica pubescens: It has the effects of dispelling wind and dampness, relieving pain and numbness. It is often used to treat diseases such as wind-cold-dampness arthralgia, lower back and knee pain, and headache due to latent wind in the Shaoyin meridian.

[0054] Loofah sponge: It is neutral in nature and sweet in taste. It enters the lung, stomach and liver meridians. It has the effects of dispelling wind and unblocking the meridians, promoting blood circulation and relieving pain, resolving phlegm and dissipating nodules, promoting lactation and reducing swelling, diuresis and detoxification, promoting lactation, clearing heat and resolving phlegm, cooling blood and stopping bleeding. It can relieve pain by unblocking the meridians and promoting blood circulation. It is suitable for symptoms such as chest and rib pain, rheumatic arthralgia, insufficient lactation, cough with lung heat, and hematochezia.

[0055] Cloves: They have the effects of warming the middle jiao and relieving nausea, tonifying the kidneys and assisting yang. They are often used to treat symptoms such as spleen and stomach deficiency and cold, hiccups and vomiting, poor appetite and diarrhea, cold pain in the heart and abdomen, and impotence due to kidney deficiency.

[0056] Safflower: It has the effects of promoting blood circulation, regulating menstruation, removing blood stasis, and relieving pain. It is often used to treat amenorrhea due to blood stasis, dysmenorrhea, postpartum abdominal pain due to blood stasis, abdominal masses, chest pain, abdominal pain due to blood stasis, hypochondriac pain, traumatic injuries, swelling and pain due to blood stasis, and dark-colored rashes.

[0057] Dandelion: It has the effects of clearing heat and detoxifying, reducing swelling and dissipating nodules, and promoting diuresis and relieving strangury. It is often used to treat boils, carbuncles, mastitis, scrofula, red eyes, sore throat, lung abscess, intestinal abscess, damp-heat jaundice, and painful urination due to heat.

[0058] Hedyotis diffusa: It has the effects of clearing heat and detoxifying, promoting diuresis and relieving jaundice. It is often used to treat lung heat cough, sore throat, intestinal abscess, boils and sores, snake bites, painful urination, edema, dysentery, enteritis, damp-heat jaundice and other diseases.

[0059] Scutellaria barbata: It has the effects of clearing heat and detoxifying, removing blood stasis and promoting diuresis. It is often used to treat boils and carbuncles, sore throat, traumatic injuries, edema, jaundice, snake and insect bites and other diseases.

[0060] Rose: It has the effects of regulating qi and relieving depression, harmonizing blood, and relieving pain. It is often used to treat liver and stomach qi pain, poor appetite and nausea, irregular menstruation, and injuries from falls.

[0061] Lobelia chinensis: It has the effects of clearing heat and detoxifying, promoting diuresis and reducing swelling. It is often used to treat snake and insect bites, carbuncles and boils, eczema, damp sores, abdominal distension and edema, jaundice and oliguria.

[0062] Red peony root: It has the effects of clearing heat and cooling blood, dispersing blood stasis and relieving pain. It is often used to treat febrile diseases with rashes, hematemesis and epistaxis, red and swollen eyes, liver stagnation and hypochondriac pain, amenorrhea and dysmenorrhea, abdominal masses and pain, traumatic injuries, carbuncles and sores, etc.

[0063] Bamboo shavings: They have the effects of clearing heat and resolving phlegm, relieving irritability and stopping vomiting. They are often used to treat phlegm-heat cough, phlegm due to gallbladder fire, irritability and vomiting, palpitations and insomnia, phlegm-induced coma due to stroke, aphasia due to stiff tongue, vomiting due to stomach heat, morning sickness during pregnancy, and threatened abortion.

[0064] Clematis chinensis: It has the effects of dispelling wind and dampness, clearing the meridians and relieving pain, and dissolving fishbone stuck in the throat. It is often used to treat rheumatic pain, numbness of limbs, muscle contracture, difficulty in flexion and extension, fishbone stuck in the throat, and other diseases.

[0065] Perilla leaves: also known as purple perilla leaves, have the effects of relieving exterior syndromes and dispelling cold, regulating qi and harmonizing the stomach. They are commonly used to treat symptoms such as colds due to wind-cold, coughs and nausea, stagnation of qi in the spleen and stomach, chest tightness, and vomiting.

[0066] Bupleurum: It has the effects of harmonizing the exterior and interior, soothing the liver and relieving depression, raising yang and lifting prolapse, and reducing fever and stopping malaria. It is often used to treat colds with fever, alternating chills and fever, chest and rib pain, irregular menstruation, uterine prolapse, rectal prolapse and other diseases.

[0067] Corydalis Rhizome (also known as Yanhusuo) has the effects of promoting blood circulation, regulating qi, and relieving pain. It is often used to treat chest and rib pain, abdominal pain, angina pectoris, amenorrhea, dysmenorrhea, postpartum blood stasis, and swelling and pain from falls and injuries.

[0068] Preferably, the weight ratio of Artemisia argyi, frankincense, and Acorus tatarinowii is (40-130):(5-12):(9-11), that is, the traditional Chinese medicine composition for treating various intractable diseases includes, by weight, 40-130 parts Artemisia argyi, 5-12 parts frankincense, 9-11 parts Acorus tatarinowii, 3-15 parts Gleditsia sinensis, 5-30 parts Citrus aurantium, 5-20 parts Ligusticum chuanxiong, 5-20 parts Cinnamomum cassia, 5-20 parts Eucommia ulmoides, 1-3 parts Buthus martensii, and 3-15 parts Angelica dahurica. Asarum 1-3 parts, rosin 1-3 parts, realgar 1-3 parts, Angelica pubescens 3-15 parts, loofah sponge 1-3 parts, clove 3-15 parts, safflower 3-15 parts, dandelion 3-15 parts, Hedyotis diffusa 3-15 parts, Scutellaria barbata 3-15 parts, rose 3-15 parts, Lobelia chinensis 3-15 parts, Paeonia lactiflora 3-15 parts, bamboo shavings 5-12 parts, Clematis chinensis 5-12 parts, Perilla frutescens 3-5 parts, Bupleurum chinense 5-12 parts, Corydalis yanhusuo 5-12 parts.

[0069] As a preferred embodiment, the weight ratio of Gleditsia sinensis, Citrus aurantium, Ligusticum chuanxiong, Cinnamomum cassia, and Eucommia ulmoides is (5-12):(8-25):(7-18):(7-18):(7-18), that is, the traditional Chinese medicine composition for treating various intractable diseases includes, by weight, 30-150 parts of Artemisia argyi, 3-15 parts of Boswellia carterii, 8-12 parts of Acorus tatarinowii, 5-12 parts of Gleditsia sinensis, 8-25 parts of Citrus aurantium, 7-18 parts of Ligusticum chuanxiong, 7-18 parts of Cinnamomum cassia, 7-18 parts of Eucommia ulmoides, and 1 part of Scorpion. -3 parts, Angelica dahurica 3-15 parts, Asarum 1-3 parts, Rosin 1-3 parts, Realgar 1-3 parts, Angelica pubescens 3-15 parts, Luffa sponge 1-3 parts, Clove 3-15 parts, Safflower 3-15 parts, Dandelion 3-15 parts, Hedyotis diffusa 3-15 parts, Scutellaria barbata 3-15 parts, Rose 3-15 parts, Lobelia chinensis 3-15 parts, Paeonia lactiflora 3-15 parts, Bambusa textilis 5-12 parts, Clematis chinensis 5-12 parts, Perilla frutescens 3-5 parts, Bupleurum chinense 5-12 parts, Corydalis yanhusuo 5-12 parts.

[0070] As a preferred embodiment, the weight ratio of scorpion, angelica dahurica, asarum, and rosin is (1.5-2.5):(5-12):(1.5-2.5):(1.5-2.5), that is, the traditional Chinese medicine composition for treating various intractable diseases includes, by weight, 30-150 parts of mugwort, 3-15 parts of frankincense, 8-12 parts of acorus tatarinowii, 3-15 parts of gleditsia sinensis, 5-30 parts of immature bitter orange, 5-20 parts of chuanxiong rhizome, 5-20 parts of cinnamon twig, 5-20 parts of eucommia bark, and 1.5-2.5 parts of scorpion. Angelica dahurica 5-12 parts, Asarum 1.5-2.5 parts, Rosin 1.5-2.5 parts, Realgar 1-3 parts, Angelica pubescens 3-15 parts, Luffa sponge 1-3 parts, Clove 3-15 parts, Safflower 3-15 parts, Dandelion 3-15 parts, Hedyotis diffusa 3-15 parts, Scutellaria barbata 3-15 parts, Rose 3-15 parts, Lobelia chinensis 3-15 parts, Paeonia lactiflora 3-15 parts, Bambusa textilis 5-12 parts, Clematis chinensis 5-12 parts, Perilla frutescens 3-5 parts, Bupleurum chinense 5-12 parts, Corydalis yanhusuo 5-12 parts.

[0071] As a preferred embodiment, the weight ratio of realgar, Angelica pubescens, loofah sponge, and clove is (1.5-2.5):(5-12):(1.5-2.5):(5-12), that is, the traditional Chinese medicine composition for treating various intractable diseases includes, by weight, 30-150 parts of Artemisia argyi, 3-15 parts of frankincense, 8-12 parts of Acorus tatarinowii, 3-15 parts of Gleditsia sinensis, 5-30 parts of Citrus aurantium, 5-20 parts of Ligusticum chuanxiong, 5-20 parts of Cinnamomum cassia, 5-20 parts of Eucommia ulmoides, 1-3 parts of Buthus martensii, and white peony root. Angelica dahurica 3-15 parts, Asarum heterotropoides 1-3 parts, Rosin 1-3 parts, Realgar 1.5-2.5 parts, Angelica pubescens 5-12 parts, Luffa cylindrica 1.5-2.5 parts, Clove 5-12 parts, Carthamus tinctorius 3-15 parts, Taraxacum mongolicum 3-15 parts, Hedyotis diffusa 3-15 parts, Scutellaria barbata 3-15 parts, Rosa rugosa 3-15 parts, Lobelia chinensis 3-15 parts, Paeonia lactiflora 3-15 parts, Bambusa textilis 5-12 parts, Clematis chinensis 5-12 parts, Perilla frutescens 3-5 parts, Bupleurum chinense 5-12 parts, Corydalis yanhusuo 5-12 parts.

[0072] As a preferred embodiment, the mass ratio of safflower, dandelion, white-flowered hedyotis diffusa, scutellaria barbata, rose, lobelia chinensis, and red peony root is (5-12):(5-12):(5-12):(5-12):(5-12):(5-12):(5-12), that is, the traditional Chinese medicine composition for treating various intractable diseases includes, by weight, 30-150 parts of mugwort, 3-15 parts of frankincense, 8-12 parts of acorus tatarinowii, 3-15 parts of soapberry, 5-30 parts of immature bitter orange peel, 5-20 parts of chuanxiong rhizome, and 5-2 parts of cinnamon twig. 0 parts, Eucommia ulmoides 5-20 parts, Scorpion 1-3 parts, Angelica dahurica 3-15 parts, Asarum 1-3 parts, Rosin 1-3 parts, Realgar 1-3 parts, Angelica pubescens 3-15 parts, Luffa cylindrica 1-3 parts, Clove 3-15 parts, Safflower 5-12 parts, Dandelion 5-12 parts, Hedyotis diffusa 5-12 parts, Scutellaria barbata 5-12 parts, Rose 5-12 parts, Lobelia chinensis 5-12 parts, Paeonia lactiflora 5-12 parts, Bambusa textilis 5-12 parts, Clematis chinensis 5-12 parts, Perilla frutescens 3-5 parts, Bupleurum chinense 5-12 parts, Corydalis yanhusuo 5-12 parts.

[0073] As a preferred formulation, the mass ratio of bamboo shavings, clematis root, perilla leaf, bupleurum root, and corydalis rhizome is (7-10):(7-10):(3.5-4.5):(7-10):(7-10), meaning that the traditional Chinese medicine composition for treating various intractable diseases includes, by weight, 30-150 parts of mugwort leaf, 3-15 parts of frankincense, 8-12 parts of acorus tatarinowii rhizome, 3-15 parts of soapberry fruit, 5-30 parts of immature bitter orange peel, 5-20 parts of chuanxiong rhizome, 5-20 parts of cinnamon twig, 5-20 parts of eucommia bark, and 1- scorpion. 3 parts, Angelica dahurica 3-15 parts, Asarum 1-3 parts, Rosin 1-3 parts, Realgar 1-3 parts, Angelica pubescens 3-15 parts, Luffa sponge 1-3 parts, Clove 3-15 parts, Safflower 3-15 parts, Dandelion 3-15 parts, Hedyotis diffusa 3-15 parts, Scutellaria barbata 3-15 parts, Rose 3-15 parts, Lobelia chinensis 3-15 parts, Paeonia lactiflora 3-15 parts, Bambusa textilis 7-10 parts, Clematis chinensis 7-10 parts, Perilla frutescens 3.5-4.5 parts, Bupleurum chinense 7-10 parts, Corydalis yanhusuo 7-10 parts.

[0074] Further, according to weight parts, the traditional Chinese medicine composition of the present invention for treating various intractable diseases preferably includes 40-130 parts of Artemisia argyi, 5-12 parts of frankincense, 9-11 parts of Acorus tatarinowii, 5-12 parts of Gleditsia sinensis, 8-25 parts of Citrus aurantium, 7-18 parts of Ligusticum chuanxiong, 7-18 parts of Cinnamomum cassia, 7-18 parts of Eucommia ulmoides, 1.5-2.5 parts of Buthus martensii, 5-12 parts of Angelica dahurica, 1.5-2.5 parts of Asarum heterotropoides, 1.5-2.5 parts of rosin, and male... Yellow 1.5-2.5 parts, Angelica pubescens 5-12 parts, Luffa sponge 1.5-2.5 parts, Syzygium aromaticum 5-12 parts, Carthamus tinctorius 5-12 parts, Taraxacum mongolicum 5-12 parts, Hedyotis diffusa 5-12 parts, Scutellaria barbata 5-12 parts, Rosa rugosa 5-12 parts, Lobelia chinensis 5-12 parts, Paeonia lactiflora 5-12 parts, Bambusa textilis 7-10 parts, Clematis chinensis 7-10 parts, Perilla frutescens 3.5-4.5 parts, Bupleurum chinense 7-10 parts, Corydalis yanhusuo 7-10 parts.

[0075] The present invention also provides a method for preparing the above-mentioned traditional Chinese medicine composition for treating various intractable diseases, comprising the following steps:

[0076] S1: Weigh out the following ingredients according to the specified proportions: Artemisia argyi, frankincense, Acorus tatarinowii, Gleditsia sinensis, Citrus aurantium, Ligusticum chuanxiong, Cinnamomum cassia, Eucommia ulmoides, Scorpion, Angelica dahurica, Asarum heterotropoides, Rosin, Realgar, Angelica pubescens, Luffa cylindrica, Clove, Safflower, Dandelion, Hedyotis diffusa, Scutellaria barbata, Rose, Lobelia chinensis, Paeonia lactiflora, Bambusa textilis, Clematis chinensis, Perilla frutescens, Bupleurum chinense, and Corydalis yanhusuo.

[0077] S2: Pulverize the medicinal materials obtained in step S1, mix them evenly, and pass them through a 30-40 mesh sieve to obtain a traditional Chinese medicine composition.

[0078] In step S1 above, if there is dirt or impurities on the surface of the medicinal material, it needs to be washed for 20-25 minutes and dried for 30 minutes. For larger pieces of medicinal material, it needs to be cut into smaller pieces with a length of 2-3 cm to facilitate better crushing.

[0079] In step S2, the medicinal materials can be put into a mixing and crushing instrument for crushing, such as a pulverizer or grinder. The medicinal materials can be added to the mixing and crushing instrument in sequence, or the harder medicinal materials can be added first, followed by the softer medicinal materials.

[0080] After placing the medicinal materials into the mixing and grinding instrument, start the instrument and adjust the speed to 500-700 r / min for 15-30 minutes to mix and grind the materials into powder. During the grinding process, the speed and time can be adjusted appropriately to ensure the materials are thoroughly pulverized and have a uniform particle size.

[0081] After being pulverized, the powder is sieved through a 30-40 mesh screen. The resulting powder can be used to make moxa sticks / moxa rods using a moxa stick mold, or it can be wrapped and packaged with non-woven fabric or similar materials to be used as a medicinal bath powder.

[0082] Moxibustion sticks can be prepared by adding water or a binder to a traditional Chinese medicine composition, stirring until homogeneous, then adding the mixture into a moxibustion stick mold, and solidifying to obtain the moxibustion stick.

[0083] The application method of the medicinal bath powder is as follows: Add water to the traditional Chinese medicine composition, heat at 80-90℃ for 2-4 hours, and filter to obtain the bath solution. The mass ratio of the traditional Chinese medicine composition to sterile water can be 1:20-1:50.

[0084] To further clarify the present invention and its technological advancements, the following description is provided in conjunction with specific embodiments and technical effects.

[0085] Example 1

[0086] This embodiment provides a traditional Chinese medicine composition for treating various intractable diseases, comprising, by weight, 85 parts of Artemisia argyi, 8 parts of frankincense, 10 parts of Acorus tatarinowii, 8 parts of Gleditsia sinensis, 17 parts of Citrus aurantium, 18 parts of Ligusticum chuanxiong, 17 parts of Cinnamomum cassia, 18 parts of Eucommia ulmoides, 2 parts of Buthus martensii, 8 parts of Angelica dahurica, 2 parts of Asarum heterotropoides, 2 parts of rosin, 2 parts of realgar, 8 parts of Angelica pubescens, 2 parts of Luffa cylindrica, 8.5 parts of clove, 8.5 parts of safflower, 8.5 parts of dandelion, 8.5 parts of Hedyotis diffusa, 8 parts of Scutellaria barbata, 8 parts of Rosa rugosa, 8.5 parts of Lobelia chinensis, 8 parts of Paeonia lactiflora, 8.5 parts of bamboo shavings, 8 parts of Clematis chinensis, 4 parts of Perilla frutescens, 8.5 parts of Bupleurum chinense, and 8 parts of Corydalis yanhusuo.

[0087] Example 2

[0088] This embodiment provides a traditional Chinese medicine composition for treating various intractable diseases, comprising, by weight, 40 parts of Artemisia argyi, 5 parts of frankincense, 9 parts of Acorus tatarinowii, 5 parts of Gleditsia sinensis, 8 parts of Citrus aurantium, 7 parts of Ligusticum chuanxiong, 7 parts of Cinnamomum cassia, 7 parts of Eucommia ulmoides, 1.5 parts of Buthus martensii, 5 parts of Angelica dahurica, 1.5 parts of Asarum heterotropoides, 1.5 parts of rosin, 1.5 parts of realgar, 5 parts of Angelica pubescens, 1.5 parts of Luffa cylindrica, 5 parts of clove, 5 parts of Carthamus tinctorius, 5 parts of Taraxacum mongolicum, 5 parts of Hedyotis diffusa, 5 parts of Scutellaria barbata, 5 parts of Rosa rugosa, 5 parts of Lobelia chinensis, 5 parts of Paeonia lactiflora, 7 parts of Bambusa textilis, 7 parts of Clematis chinensis, 3.5 parts of Perilla frutescens, 7 parts of Bupleurum chinense, and 7 parts of Corydalis yanhusuo.

[0089] Example 3

[0090] This embodiment provides a traditional Chinese medicine composition for treating various intractable diseases, comprising, by weight, 130 parts of Artemisia argyi, 12 parts of frankincense, 11 parts of Acorus tatarinowii, 12 parts of Gleditsia sinensis, 25 parts of Citrus aurantium, 18 parts of Ligusticum chuanxiong, 18 parts of Cinnamomum cassia, 18 parts of Eucommia ulmoides, 2.5 parts of Buthus martensii, 12 parts of Angelica dahurica, 2.5 parts of Asarum heterotropoides, 2.5 parts of rosin, 2.5 parts of realgar, 12 parts of Angelica pubescens, 2.5 parts of Luffa cylindrica, 12 parts of clove, 12 parts of Carthamus tinctorius, 12 parts of Taraxacum mongolicum, 12 parts of Hedyotis diffusa, 12 parts of Scutellaria barbata, 12 parts of Rosa rugosa, 12 parts of Lobelia chinensis, 12 parts of Paeonia lactiflora, 10 parts of Bambusa textilis, 10 parts of Clematis chinensis, 4.5 parts of Perilla frutescens, 10 parts of Bupleurum chinense, and 10 parts of Corydalis yanhusuo.

[0091] Example 4

[0092] This embodiment provides a traditional Chinese medicine composition for treating various intractable diseases, comprising, by weight, 30 parts of Artemisia argyi, 3 parts of frankincense, 8 parts of Acorus tatarinowii, 3 parts of Gleditsia sinensis, 5 parts of Citrus aurantium, 5 parts of Ligusticum chuanxiong, 5 parts of Cinnamomum cassia, 5 parts of Eucommia ulmoides, 1 part of Buthus martensii, 3 parts of Angelica dahurica, 1 part of Asarum heterotropoides, 1 part of rosin, 1 part of realgar, 3 parts of Angelica pubescens, 1 part of Luffa cylindrica, 3 parts of clove, 3 parts of safflower, 3 parts of dandelion, 3 parts of Hedyotis diffusa, 3 parts of Scutellaria barbata, 3 parts of Rosa rugosa, 3 parts of Lobelia chinensis, 3 parts of Paeonia lactiflora, 5 parts of bamboo shavings, 5 parts of Clematis chinensis, 3 parts of Perilla frutescens, 5 parts of Bupleurum chinense, and 5 parts of Corydalis yanhusuo.

[0093] Example 5

[0094] This embodiment provides a traditional Chinese medicine composition for treating various intractable diseases, comprising, by weight, 150 parts of Artemisia argyi, 15 parts of frankincense, 12 parts of Acorus tatarinowii, 15 parts of Gleditsia sinensis, 30 parts of Citrus aurantium, 20 parts of Ligusticum chuanxiong, 20 parts of Cinnamomum cassia, 20 parts of Eucommia ulmoides, 3 parts of Buthus martensii, 15 parts of Angelica dahurica, 3 parts of Asarum heterotropoides, 3 parts of rosin, 3 parts of realgar, 15 parts of Angelica pubescens, 3 parts of Luffa cylindrica, 15 parts of clove, 15 parts of safflower, 15 parts of dandelion, 15 parts of Hedyotis diffusa, 15 parts of Scutellaria barbata, 15 parts of Rosa rugosa, 15 parts of Lobelia chinensis, 15 parts of Paeonia lactiflora, 12 parts of bamboo shavings, 12 parts of Clematis chinensis, 5 parts of Perilla frutescens, 12 parts of Bupleurum chinense, and 12 parts of Corydalis yanhusuo.

[0095] Example 6

[0096] This embodiment provides a traditional Chinese medicine composition for treating various intractable diseases. The difference from Embodiment 4 is that the composition contains 40 parts of Artemisia argyi, 5 parts of frankincense, and 9 parts of Acorus tatarinowii.

[0097] Example 7

[0098] This embodiment provides a traditional Chinese medicine composition for treating various intractable diseases. The difference from Embodiment 5 is that the composition contains 130 parts of Artemisia argyi, 12 parts of frankincense, and 11 parts of Acorus tatarinowii.

[0099] Example 8

[0100] This embodiment provides a traditional Chinese medicine composition for treating various intractable diseases. The difference from Embodiment 4 is that the composition contains 5 parts of Gleditsia sinensis, 8 parts of Citrus aurantium, 7 parts of Ligusticum chuanxiong, 7 parts of Cinnamomum cassia, and 7 parts of Eucommia ulmoides.

[0101] Example 9

[0102] This embodiment provides a traditional Chinese medicine composition for treating various intractable diseases. The difference from Embodiment 5 is that the composition contains 12 parts of Gleditsia sinensis, 25 parts of Citrus aurantium, 18 parts of Ligusticum chuanxiong, 18 parts of Cinnamomum cassia, and 18 parts of Eucommia ulmoides.

[0103] Example 10

[0104] This embodiment provides a traditional Chinese medicine composition for treating various intractable diseases. The difference from Embodiment 4 is that the composition contains 1.5 parts of whole scorpion, 5 parts of angelica dahurica, 1.5 parts of asarum, and 1.5 parts of rosin.

[0105] Example 11

[0106] This embodiment provides a traditional Chinese medicine composition for treating various intractable diseases. The difference from Embodiment 5 is that the composition contains 2.5 parts of whole scorpion, 12 parts of angelica dahurica, 2.5 parts of asarum, and 2.5 parts of rosin.

[0107] Example 12

[0108] This embodiment provides a traditional Chinese medicine composition for treating various intractable diseases. The difference from Embodiment 4 is that the composition contains 1.5 parts realgar, 5 parts Angelica pubescens, 1.5 parts loofah sponge, and 5 parts cloves.

[0109] Example 13

[0110] This embodiment provides a traditional Chinese medicine composition for treating various intractable diseases. The difference from Example 5 is that the composition contains 2.5 parts realgar, 12 parts Angelica pubescens, 2.5 parts loofah sponge, and 12 parts cloves.

[0111] Example 14

[0112] This embodiment provides a traditional Chinese medicine composition for treating various intractable diseases. The difference from Embodiment 4 is that the composition consists of 5 parts safflower, 12 parts dandelion, 5 parts oldenlandia diffusa, 12 parts scutellaria barbata, 5 parts rose, 12 parts lobelia chinensis, and 5 parts red peony root.

[0113] Example 15

[0114] This embodiment provides a traditional Chinese medicine composition for treating various intractable diseases. The difference from Embodiment 5 is that the composition contains 12 parts safflower, 5 parts dandelion, 12 parts oldenlandia diffusa, 5 parts scutellaria barbata, 12 parts rose, 5 parts lobelia chinensis, and 12 parts red peony root.

[0115] Example 16

[0116] This embodiment provides a traditional Chinese medicine composition for treating various intractable diseases. The difference from Embodiment 4 is that the composition contains 7 parts bamboo shavings, 10 parts clematis root, 3.5 parts perilla leaf, 7 parts bupleurum root, and 10 parts corydalis rhizome.

[0117] Example 17

[0118] This embodiment provides a traditional Chinese medicine composition for treating various intractable diseases. The difference from Embodiment 5 is that the composition contains 10 parts of bamboo shavings, 7 parts of clematis root, 4.5 parts of perilla leaf, 10 parts of bupleurum root, and 7 parts of corydalis rhizome.

[0119] Comparative Example 1

[0120] This comparative example provides a traditional Chinese medicine composition for treating various intractable diseases, comprising 150 parts of Artemisia argyi, 15 parts of sulfur, 15 parts of frankincense, 0.5 parts of musk, 15 parts of Gleditsia sinensis, 30 parts of Citrus aurantium, 20 parts of Ligusticum chuanxiong, 20 parts of Cinnamomum cassia, 20 parts of Eucommia ulmoides, 3 parts of Buthus martensii, 15 parts of Angelica dahurica, 3 parts of Asarum heterotropoides, 3 parts of rosin, 3 parts of realgar, 15 parts of Angelica pubescens, 3 parts of pangolin scales, 15 parts of clove, 15 parts of safflower, 15 parts of dandelion, 15 parts of Hedyotis diffusa, 15 parts of Scutellaria barbata, 15 parts of Rosa rugosa, 15 parts of Lobelia chinensis, 15 parts of Paeonia lactiflora, 12 parts of bamboo shavings, 12 parts of Clematis chinensis, 5 parts of Perilla frutescens, 12 parts of Bupleurum chinense, and 12 parts of Corydalis yanhusuo.

[0121] Comparative Example 2

[0122] This comparative example provides a traditional Chinese medicine composition for treating various intractable diseases. The difference from Example 1 is that the amount of Acorus tatarinowii is 0.5 parts.

[0123] The Chinese herbal combinations of Examples 1-17 and Comparative Examples 1-2 were cut into pieces, then crushed in a pulverizer, and then sieved through a 35-mesh sieve to obtain herbal powder. The powder was then used to make moxa sticks of the same size using a moxa stick mold, and was designated as Products 1-17 and Controls 1-2, respectively.

[0124] Products 1-17 and reference samples 1-2 were ignited separately. A comparison revealed that reference sample 1 exhibited a distinctly pungent odor during combustion, likely due to its sulfur content. Furthermore, compared to reference sample 1, products 1-17 and reference sample 2 burned more evenly, produced more stable heat, lasted longer, and generated less ash.

[0125] Clinical treatment cases

[0126] Case 1

[0127] Mr. Xu, 55 years old, male, office worker, has had protruding eyes for more than 5 years.

[0128] Present Illness: The patient began experiencing bulging eyes 5 years ago. The patient reports symptoms including irritability, excessive sweating while walking, sitting, or lying down, and itchy skin. The tongue is red with a greasy coating, and there is phlegm under the tongue. The pulse is thready and rapid.

[0129] The patient presented with hyperthyroidism, with elevated T3 and T4 levels. Self-administered methimazole was ineffective and the condition worsened. Later, renal and pancreatic cysts were discovered, the largest measuring 3.0*3.9 cm. After one month of treatment with this formula, the cyst shrank to 2.7 cm, and after two months, a follow-up examination showed it had further shrunk to 1.5*1.4*1.1 cm. The patient also presented with benign prostatic hyperplasia (BPH) with calcification and high uric acid. After several treatments, bowel movements and urination returned to normal (clinical symptoms of BPH with calcification include frequent urination, urgency, painful urination, and frequent nocturnal urination). The patient's legs regained strength, and all the aforementioned clinical symptoms disappeared. The tongue was red with a white coating, and the pulse was strong.

[0130] The patient had no medical history or drug allergies. Physical examination revealed that the patient was in fair condition. Traditional Chinese medicine diagnosis showed a red tongue with a greasy coating, phlegm under the tongue, and a thready and rapid pulse.

[0131] Preliminary diagnosis: 1. Goiter; 2. Qi stagnation and blood stasis syndrome; 3. Hyperthyroidism.

[0132] Patient 1 in Case 1 received moxibustion treatment twice a week, for 30-60 minutes each time. The patient's mental state was good, emotions were stable, and irritability was significantly reduced. Protrusion of both eyes was significantly alleviated, with no obvious photophobia, tearing, or blurred vision. Skin itching had largely disappeared, and sweating had returned to normal. Bowel movements decreased in frequency, became formed, and regular; urination was smooth, with reduced nocturia. Lower limb movement was free and strong. The tongue was pale red with a thin, greasy coating, and sublingual petechiae had decreased; the pulse was thready and slow, showing significant improvement. Follow-up thyroid function tests showed that T3 and T4 levels had returned to normal, and TSH had risen back to the normal range. Kidney and pancreatic cysts further shrank, showing no significant enlargement trend and no compressive symptoms. Prostatic hyperplasia was stable, and calcifications showed no progression. Uric acid levels decreased, trending towards the normal range.

[0133] As can be seen from the above, after moxibustion treatment with product 1, the patient's hyperthyroidism was well controlled, related complications and systemic symptoms were significantly improved, quality of life was significantly improved, TCM syndrome was also significantly improved, and the patient was in a stable period overall.

[0134] Case 2

[0135] Ms. Wu, 48 years old, female, office worker, has been suffering from dysmenorrhea for several months.

[0136] Present Illness: The patient began experiencing dysmenorrhea several months ago. An external hospital diagnosed her with adenomyosis. She has a history of dysmenorrhea, which has improved after treatment with traditional Chinese medicine and acupuncture. Current symptoms include thyroid nodules, liver cysts, dizziness, anemia, good appetite, good sleep, good bowel movements, red tongue with dark coating, and weak pulse.

[0137] The patient had no medical history or drug allergies. Physical examination revealed that the patient was in fair condition. Traditional Chinese medicine diagnosis showed that the tongue was red with a dark coating and the pulse was weak.

[0138] Preliminary diagnosis: 1. Adenomyosis; 2. Thyroid nodules; 3. Liver stagnation and phlegm accumulation syndrome.

[0139] Patient 2 in Case 2 received moxibustion treatment using Product 2, 2-3 times per week, 30 minutes each time, for 4 consecutive weeks. After 4 weeks, the patient's mental state was good, emotions were stable, dysmenorrhea symptoms were significantly relieved, menstrual cycles became regular, menstrual flow increased, menstrual color turned red, no blood clots, and menstrual discomfort decreased or disappeared. A follow-up ultrasound showed that the adenomyosis had shrunk in size. The thyroid nodule decreased in size, with clear borders and regular shape; the liver cyst shrank and no longer caused significant compression symptoms. In addition, the patient's dizziness lessened, complexion became rosier, fatigue improved, and a follow-up blood test showed an improvement in anemia indicators. Appetite and sleep were good, bowel movements were regular and smooth. The tongue was pale red with a thin white coating, and the pulse was stronger, with improvement in weak pulse.

[0140] As can be seen from the above, after moxibustion treatment with product 2, the patient's symptoms related to adenomyosis were significantly relieved, her endocrine and overall condition improved, and her TCM symptoms also showed significant improvement. Overall, she was in a stable condition.

[0141] Case 3

[0142] Ms. Shen, 71 years old, retired, has had facial lip movements for over 10 years.

[0143] Present Illness: The patient began experiencing lip tremors more than 10 years ago, along with a history of headaches. The tremors worsened after COVID-19. The patient has a family history of stroke, swollen lymph nodes behind the ear, right shoulder pain, constipation, a white tongue with petechiae, and a weak, rapid pulse. After treatment with traditional Chinese medicine and acupuncture, the lip tremors have significantly improved. Appetite is fair, sleep quality has improved, bowel movements are normal, the tongue is red with a white coating, and the pulse is even and strong.

[0144] The patient had no medical history or drug allergies. Physical examination revealed that the patient was in fair condition. Traditional Chinese medicine diagnosis showed that the tongue had petechiae and a white coating, and the pulse was soft and rapid.

[0145] Preliminary diagnosis: 1. Tremor; 2. Internal wind syndrome; 3. Parkinson's syndrome.

[0146] Patient 3 in Case 3 received moxibustion treatment using Product 3, several times a day for a total of 4 hours, for 4 consecutive weeks. After 4 weeks, the patient's mental state was good and emotions were stable. The previously present lip tremor completely disappeared and did not recur. Headache symptoms were significantly relieved, and right shoulder pain also improved markedly. The swelling of the lymph nodes behind the ear returned to normal, without tenderness or other discomfort. The patient's sleep quality improved. Appetite remained good, and weight remained stable. Constipation was relieved, and bowel movements became smooth and at normal frequency. Tongue examination revealed the disappearance of petechiae, and the tongue coating was white and thin; the pulse changed from the previous soft and rapid to a steady and strong pulse, indicating that the internal environment was approaching balance.

[0147] As can be seen from the above, after moxibustion treatment with product 3, the patient's tremor, liver wind syndrome, and Parkinson's syndrome-related clinical manifestations have been well controlled and improved, and the quality of life has been significantly improved.

[0148] Case 4

[0149] Mr. Zhou, 54 years old, male, office worker, suffered from insomnia for more than 14 years. His condition worsened the day before his visit, and he had not slept for nearly 36 hours.

[0150] Present Illness: The patient reported experiencing anxiety and insomnia 14 years ago due to family changes. In 2023, after being exposed to cold while working in a mine, his sleep continued to worsen. He experienced severe insomnia one day before seeking medical attention. He is currently experiencing lethargy, emotional breakdown, phlegm, loose stools, a dark purple tongue with a white and greasy coating and teeth marks, and a deep and weak pulse.

[0151] No medical history, no history of drug allergies. Physical examination: general condition is fair. Traditional Chinese medicine diagnosis: dark purple tongue with white and greasy coating and teeth marks; deep and weak pulse.

[0152] Preliminary diagnosis: 1. Insomnia; 2. Liver Qi stagnation syndrome.

[0153] Patient 4 in Case 4 received moxibustion treatment using Product 4. On the day of the consultation, the treatment lasted one hour, during which the patient fell asleep. Moxibustion was administered every other day for one hour each time. After two weeks of continuous treatment, the patient's mental state was good, emotions were stable, and anxiety was significantly relieved. Insomnia symptoms improved significantly; falling asleep was easier, sleep duration was longer, and the patient was less likely to wake up at night, waking up refreshed in the morning. Additionally, the patient's sputum production significantly decreased, and coughing was essentially eliminated; bowel movements became formed, loose stools disappeared, and defecation became regular; urination was normal and smooth. The tongue changed from dark purple to pale red, the white, greasy coating lessened, teeth marks decreased, and the pulse changed from deep and weak to moderate and forceful.

[0154] As shown above, after moxibustion treatment with product 4, the patient's anxiety was largely relieved, sleep returned to normal, stress resistance was enhanced, and quality of life significantly improved. Traditional Chinese medicine diagnosis indicated a marked improvement in symptoms of liver qi stagnation and phlegm-dampness obstruction, indicating the patient is generally in a stable condition.

[0155] Case 5

[0156] Ms. Wu, 69 years old, retired, has had coldness in both lower groins and feet for several years, which has worsened in the past year.

[0157] Present Illness: The patient began experiencing coldness in both lower limbs and feet several years ago, which worsened a year ago. Western medicine diagnosed femoral head necrosis, and on July 31, 2023, underwent a right femoral head replacement surgery. Post-operatively, the patient experienced pain in the right lower limb, and prolonged bed rest led to bedsores, making standing difficult. The patient wakes up around 11 PM, 1 AM, and 3 AM every night, suffering from insomnia and an inability to fall asleep normally. The patient has also experienced constipation for several years. The tongue is red with petechiae, the coating is white, and the pulse is wiry and rapid.

[0158] Past medical history: Hypertension for 30 years, diabetes for 20 years, and gallstones. No history of drug allergies. Physical examination: General condition is fair. Traditional Chinese medicine diagnosis: Red tongue with petechiae, white coating, and wiry, rapid pulse.

[0159] Preliminary diagnosis: 1. Arthralgia; 2. Liver stagnation and blood stasis syndrome.

[0160] Patient 5 in Case 5 received moxibustion treatment with product 5, twice daily for 30-120 minutes each time, for four consecutive weeks. After four weeks, the patient's mental state was good, and the coldness in both lower limbs and feet was significantly reduced, with no further persistent cold discomfort. Nighttime sleep improved, with fewer nighttime awakenings (now only occasionally waking once), and faster sleep quality. Constipation was significantly relieved, with smooth and regular bowel movements, and no obvious abdominal distension or hardening. Appetite was good, and weight remained stable. The tongue changed from red to pale, with fewer petechiae, a thin white coating, and a milder, more wiry pulse. Underlying conditions of hypertension and diabetes were well controlled, with no significant worsening of complications; gallstones were stable, with no acute attacks. Overall quality of life significantly improved, mobility increased, and basic self-care was achieved. At the follow-up visit after seven weeks of moxibustion treatment, the patient reported significant pain reduction and was able to walk.

[0161] As can be seen from the above, after moxibustion treatment with product 5, the patient's "liver stagnation and blood stasis" symptoms were significantly improved, the flow of qi and blood became smoother, and the symptoms of cold stagnation in the blood vessels were relieved.

[0162] Case 6

[0163] Ms. Zhao, 46 ​​years old, female, office worker, has a sleep deficit of 10 years.

[0164] Present Illness: The patient had poor sleep after going 7 days and nights without sleep due to some event several decades ago. After treatment with traditional Chinese medicine and acupuncture, her sleep time has been prolonged. She also has scanty menstruation, good appetite, constipation, a red tongue with a white coating and a depression in the middle, and a rapid pulse.

[0165] No medical history, no history of drug allergies. Physical examination: general condition is fair. Traditional Chinese medicine diagnosis: red tongue with white coating, concave in the middle, rapid pulse.

[0166] Preliminary diagnosis: 1. Insomnia; 2. Liver stagnation transforming into fire syndrome.

[0167] Patient 6 in Case 6 received moxibustion treatment using Product 6, once every other day for one hour each time, for four consecutive weeks. After four weeks, the patient's mental state was good, emotions were stable, insomnia symptoms significantly improved, sleep duration was extended and quality improved, and problems such as difficulty falling asleep and frequent awakenings at night were basically resolved. Currently, the patient is able to maintain a relatively regular sleep schedule and feels energetic upon waking. Menstrual flow has improved, menstrual cycles are more regular, and blood color is more rosy than before. Appetite is good, and weight is stable. Constipation has been relieved, bowel movements are gradually returning to normal, and defecation is smooth with no significant abdominal distension or discomfort. Tongue examination revealed that the tongue body changed from red to pale, the tongue coating was white and thin, and the central depression was reduced; the pulse rate also eased, presenting an overall more balanced state. This indicates that the symptoms of liver stagnation transforming into fire have been effectively controlled, and the flow of qi and blood is trending towards balance.

[0168] As can be seen from the above, after moxibustion treatment with product 6, the patient's insomnia, liver stagnation with fire syndrome and related symptoms have been well controlled and improved.

[0169] Case 7

[0170] Ms. Li, 59 years old, a worker, has suffered from stomach pain for several years.

[0171] Present Illness: The patient began experiencing stomach pain several years ago. Previous hospital findings included chronic non-ablative gastritis with erosion, multiple polyps in the duodenum and stomach, a lipoma on the back (more than 10 years post-surgery), back throbbing pain, post-cholecystectomy, post-hysterectomy and adnexectomy, bilateral pulmonary nodules, ground-glass opacity in the left lung, eye swelling, lacunar infarction, fatigue, and bitter taste in the mouth. After treatment with traditional Chinese medicine and acupuncture, and discontinuation of bismuth magnesium granules, bowel movements have improved, reflux has lessened, and appetite is good. The tongue is red with a yellow, greasy coating and cracks. The left pulse is slippery, and the right pulse is weak.

[0172] The patient had no medical history or drug allergies. Physical examination revealed that the patient was in fair condition. Traditional Chinese medicine diagnosis showed that the tongue was red with a yellow and greasy coating and cracks, the left pulse was slippery, and the right pulse was weak.

[0173] Preliminary diagnosis: 1. Stomach pain; 2. Stomach yin deficiency and qi stagnation syndrome; 3. Erosive gastritis.

[0174] Patient 7 in Case 7 received moxibustion treatment with Product 7, three times a week for 40 minutes each time, for four consecutive weeks. After four weeks, the patient's mental state was good, stomach pain symptoms were significantly relieved, with occasional mild discomfort, no obvious burning sensation or persistent pain. Appetite was good, with no obvious abdominal distension or acid reflux after eating, and digestive function was significantly improved compared to before. The tongue changed from red to pale, the yellow and greasy coating lessened, and the cracks decreased; the left pulse was smoother, and the right pulse was stronger than before, indicating that the damp heat in the body was gradually clearing, the stomach yin was recovering, and the circulation of qi and blood was approaching balance. The bitter taste in the mouth was reduced or disappeared, fatigue was relieved, and energy was more abundant than before. The swelling of the eyes improved, with no obvious edema. The original back pain symptoms were relieved, and the quality of life improved. The nodules in both lungs were stable, with no obvious progression; the ground-glass nodule in the left lung was being followed up regularly, and there were no signs of malignancy so far. There was no recurrence or complications in the patient's previous surgical history (cholecystectomy, hysterectomy, post-lipoma surgery). The patient has multiple polyps in the gastrointestinal tract and is undergoing regular check-ups; the condition is stable.

[0175] As can be seen from the above, after moxibustion treatment with product 7, the patient's stomach pain and related TCM symptoms were significantly relieved, the condition of chronic erosive gastritis was stabilized, the underlying diseases of multiple systems throughout the body were under control, and the overall health status was significantly improved.

[0176] Case 8

[0177] Ms. Zhang, 32 years old, female, worker, has been experiencing recurrent body aches for several months, which have worsened in the past two days.

[0178] Present Illness: The patient began experiencing recurrent body aches several months ago, which have worsened in the past two days. An external hospital report indicated hypothyroidism, Staphylococcus aureus resistance, and a 7cm uterine fibroid. She is currently taking levothyroxine. She also has boils on her skin and conjunctivitis. Her appetite and vision are good, and her bowel movements and urination are normal. Her tongue is red with a slightly yellow coating, and her pulse is deep.

[0179] The patient had no medical history or drug allergies. Physical examination revealed that the patient was in fair condition. Traditional Chinese medicine diagnosis showed that the tongue was red with a slightly yellow coating and the pulse was deep.

[0180] Preliminary diagnosis: 1. Goiter; 2. Qi stagnation and blood stasis syndrome; 3. Hypothyroidism.

[0181] Patient 8 in Case 8 received moxibustion treatment twice a week for 30 minutes each time for four consecutive weeks. After four weeks, the patient's mental state was good and emotions were stable. The previously recurring symptoms of general pain were significantly relieved, and no further significant general discomfort occurred. The recent worsening of symptoms was effectively controlled, and physical strength gradually recovered. Thyroid function returned to the normal range, with no obvious hypothyroidism-related symptoms such as fatigue and cold intolerance. Skin boils healed well, and no new lesions appeared; conjunctivitis symptoms completely disappeared, vision was clear, and there was no foreign body sensation or redness. Appetite was good, and weight was stable. Bowel movements were regular and smooth, with no constipation or diarrhea. Tongue examination revealed that the tongue body changed from red to pale, the slightly yellow coating lessened, and the pulse was deeper and stronger than before, indicating that the inflammatory response and endocrine imbalance in the body had been effectively corrected, and the overall health condition was trending towards stability. The uterine fibroid size was monitored, and the 7cm fibroid showed no significant growth trend, nor did it cause any compression symptoms or other complications.

[0182] As can be seen from the above, after moxibustion treatment with product 8, the patient's symptoms such as whole-body pain, skin boils, and ocular colitis have been well controlled and improved, thyroid function has returned to normal, and the condition of uterine fibroids has stabilized.

[0183] Case 9

[0184] Ms. Li, 46 years old, female, office worker, had been experiencing irregular vaginal bleeding for more than 20 days.

[0185] Present Illness: The patient experienced amenorrhea for 2 months, followed by menstruation that lasted 20 days. An external hospital report indicated thickened endometrium. Following a curettage, bleeding has stopped for 2 weeks. The patient also has anemia, a fractured right hand, good appetite, loose stools, a red tongue with teeth marks, a white tongue coating, and a wiry pulse.

[0186] No medical history, no history of drug allergies. Physical examination: general condition is fair. Traditional Chinese medicine diagnosis: red tongue with teeth marks, white coating, and wiry pulse.

[0187] Preliminary diagnosis: 1. Metrorrhagia; 2. Liver Qi stagnation and blood deficiency syndrome; 3. Irregular menstruation.

[0188] Patient 9 in Case 9 received moxibustion treatment with Product 9, three times a week for 60 minutes each time, for four consecutive weeks. After four weeks, the patient's mental state was good and her emotions were stable. Irregular vaginal bleeding had stopped, her menstrual cycle became more regular, and there was no continuous or intermittent abnormal bleeding. Her original anemia symptoms improved significantly, her complexion was rosier than before, and her fatigue was reduced. A follow-up blood test showed that her hemoglobin level had returned to near the normal range. Her right hand fracture healed well, with no obvious swelling or functional impairment. Her loose stools were significantly relieved, and her bowel movements became formed and regular, with improved digestive function. Her appetite was good, and her weight was stable. Tongue examination showed that the tongue body changed from red to pale, the teeth marks decreased, and the coating was thin and white; the pulse was more wiry and gentler than before, indicating that the symptoms of liver stagnation and blood deficiency had been significantly relieved, and the circulation of qi and blood was becoming more harmonious.

[0189] As can be seen from the above, after moxibustion treatment with product 9, the patient's "metrorrhagia" symptoms were well controlled, the menstrual cycle gradually returned to normal, and the TCM diagnosis of "liver stagnation and blood deficiency syndrome" also showed significant improvement, with the overall condition remaining stable.

[0190] Case 10

[0191] Ms. Meng, 37 years old, female, office worker, has had nasal congestion and yellow nasal discharge for several months.

[0192] Present illness: The patient began experiencing nasal congestion and yellow nasal discharge several months ago. Other hospitals reported sinusitis, buttock pain, and improved cold extremities. Appetite was good, but sleep was poor and easily awakened. Constipation was present. The tongue was red with a white, slippery coating, and the pulse was rapid.

[0193] No medical history, no history of drug allergies. Physical examination: general condition is fair. Traditional Chinese medicine diagnosis: red tongue with white and slippery coating, rapid pulse.

[0194] Preliminary diagnosis: 1. Nasal congestion; 2. Phlegm-dampness accumulation in the lungs; 3. Chronic rhinitis.

[0195] Patient 10 received moxibustion treatment using product 10, three times a week for 50 minutes each time, for four consecutive weeks. After four weeks, the patient's mental state was good and emotions were stable. Nasal congestion and yellow nasal discharge were significantly relieved, breathing was smooth, and there was no obvious nasal blockage or yellow discharge. The previous buttock pain completely disappeared, and the temperature of the extremities returned to normal, with no longer feeling cold. Sleep quality improved, although there were still occasional awakenings, but the overall sleep time was longer and the depth increased. Appetite was good, and weight was stable. Constipation was significantly improved, stools gradually became formed, bowel movements were smooth, and there was no obvious abdominal distension or discomfort. Tongue observation showed that the tongue body changed from red to pale, and the white and slippery coating was reduced; the pulse was slower and stronger than before, indicating that the phlegm and dampness accumulation in the lungs was effectively controlled, and the overall health status was approaching balance.

[0196] As can be seen from the above, after moxibustion treatment with product 10, the patient's nasal congestion, phlegm-dampness accumulation in the lungs, and related symptoms have been well controlled and improved.

[0197] Case 11

[0198] Wang, female, 3 years and 6 months old, has been suffering from indigestion for several months.

[0199] Present illness: The child began to have food stagnation several months before the start of treatment. The child was born prematurely at 27 weeks with a birth weight of 1.9 pounds. The child had a history of weakness, periumbilical pain, constipation, and two episodes of mycoplasma pneumonia. The child had a good appetite, a red tongue with a white coating, and a thready pulse.

[0200] No medical history, no history of drug allergies. Physical examination: general condition is fair. Traditional Chinese medicine diagnosis: red tongue with white coating, thready pulse.

[0201] Preliminary diagnosis: 1. Food stagnation; 2. Spleen and stomach disharmony.

[0202] Patient 11 in Case 11 received moxibustion treatment three times a week for 30 minutes each time, for four consecutive weeks. After four weeks, the child's mental state was good, activity level increased, appetite was more stable than before, and there was no obvious abdominal distension, belching, or refusal to eat after meals; symptoms of food stagnation were significantly reduced. Periumbilical pain had basically disappeared, with occasional mild discomfort but no persistent abdominal pain. Bowel movements were smooth, soft, and formed, with regular defecation; there was no recurrence of constipation or difficulty in defecation. The tongue was pale red with a thin white coating, and the pulse was thready but stronger than before, indicating that spleen and stomach function was gradually recovering and qi and blood production was gradually increasing. The previous weakness had improved, weight gain was more stable, energy was more abundant than before, and there were no recurring mycoplasma pneumonia infections. Compared with children of the same age, growth and development showed significant progress, and nutritional status improved.

[0203] As can be seen from the above, after moxibustion treatment with product 11, the child's "food stagnation" symptoms were well controlled, the "spleen and stomach disharmony" was significantly relieved, and the digestive and absorption functions gradually returned to normal.

[0204] Case 12

[0205] Mr. Gao, 65 years old, male, retired, has been experiencing abdominal discomfort for more than 10 years.

[0206] Present Illness: The patient began experiencing abdominal discomfort more than 10 years ago. An external hospital diagnosed gallstones with a sludge-like appearance. After treatment with traditional Chinese medicine and acupuncture, the patient's bloating and precordial discomfort have improved. Hemorrhoids, appetite, sleep, and bowel movements are normal. The tongue is deviated, red, with a yellow and greasy coating at the root. The pulse is deep.

[0207] No medical history, no history of drug allergies. Physical examination: general condition is fair. Traditional Chinese medicine diagnosis: tongue is deviated, red, with a yellow and greasy coating at the root of the tongue, and the pulse is deep.

[0208] Preliminary diagnosis: 1. Cholelithiasis; 2. Damp-heat syndrome of liver and gallbladder; 3. Cholelithiasis; 4. Qi deficiency syndrome of liver and gallbladder.

[0209] Patient 12 in Case 12 received moxibustion treatment three times a week for 40 minutes each time, for four consecutive weeks. After four weeks, the patient's mental state was good and emotions were stable. The previously long-standing abdominal discomfort significantly decreased or disappeared, with no significant right upper quadrant bloating or dull pain, and no significant discomfort after eating. Follow-up examination showed a reduction in gallstones or the expulsion of sludge-like stones; the gallbladder wall was smooth with no obvious signs of inflammation. Hemorrhoids had healed, with no local symptoms such as redness, swelling, heat, or pain. Appetite remained good, sleep was stable, and bowel movements were regular, with no alternating constipation or diarrhea. Tongue examination showed a more upright tongue, reduced deviation, a change from red to pale, and a reduced yellow and greasy coating at the root of the tongue. The pulse was deeper and stronger than before, indicating relief of damp-heat in the liver and gallbladder, and improvement in qi deficiency constitution.

[0210] As can be seen from the above, after moxibustion treatment with product 12, the patient's "gallstone disease" condition stabilized, and both "liver and gallbladder damp-heat syndrome" and "liver and gallbladder qi deficiency syndrome" showed significant improvement, with the overall health condition tending to be stable.

[0211] Case 13

[0212] Ms. Qian, 69 years old, retired, has had discomfort in the precordial region for several years.

[0213] Present Illness: The patient began experiencing discomfort in the precordial region several years ago. Examinations at other hospitals indicated myocardial infarction and coronary heart disease. The precordial discomfort has been relieved after treatment with traditional Chinese medicine. The patient also has a night cough, good appetite, good sleep, light yellow urine, and one bowel movement per day. The tongue is red with a greasy coating, the right pulse is thready, and the left pulse is rapid.

[0214] Past medical history: Coronary heart disease, diabetes for 20 years, no history of drug allergies. Physical examination: General condition is fair. Traditional Chinese medicine diagnosis: Red tongue with greasy coating, thin pulse on the right, and rapid pulse on the left.

[0215] Preliminary diagnosis: 1. Chest pain; 2. Qi and blood stagnation syndrome; 3. Coronary heart disease with arrhythmia.

[0216] Patient 13 in Case 13 received moxibustion therapy via Product 13, once every other day for one hour each time, for four consecutive weeks. After four weeks, the patient's mental state was good and emotions were stable. The original discomfort in the precordial region had largely disappeared, with no obvious chest tightness, chest pain, or shortness of breath. Symptoms such as palpitations and shortness of breath, similar to angina, no longer occurred after daily activities. Night cough symptoms were significantly reduced, with occasional mild coughing, no sputum or a small amount of white sputum, which did not affect sleep. Appetite was normal, sleep was fair, urine was pale yellow and plentiful, and bowel movements were once daily, formed and smooth. The tongue changed from red to pale, the greasy coating lessened, and the pulse was faster on the left and thinner on the right, becoming more moderate and forceful than before, indicating that the flow of Qi and blood was becoming smoother, the heart Yang was being promoted, and the symptoms of phlegm and blood stasis obstructing the meridians were alleviated. Previous coronary heart disease and diabetes were stable, blood sugar was well controlled, and no acute cardiovascular events occurred. Electrocardiogram or Holter monitoring showed improvement in arrhythmias, with no significant ST-T abnormalities.

[0217] As can be seen from the above, after moxibustion treatment with product 13, the patient's symptoms of "chest pain and heart pain" were significantly relieved, "qi and blood stagnation syndrome" was effectively improved, and the coronary heart disease was in a stable period overall.

[0218] Case 14

[0219] Mr. Meng, 64 years old, male, retired, has been feeling weak for several months.

[0220] Present Illness: Several months ago, the patient experienced fatigue for several months after contracting COVID-19. Other hospitals reported hepatic hemangioma, elevated total bilirubin, high blood lipids, mitral and tricuspid regurgitation, and normal appetite, improved sleep with easy awakening, normal bowel movements, red tongue with white and greasy coating, and slow pulse.

[0221] No medical history, no history of drug allergies. Physical examination: general condition is fair. Traditional Chinese medicine diagnosis: red tongue with white and greasy coating, slow pulse.

[0222] Preliminary diagnosis: 1. Fatigue; 2. Qi and blood deficiency syndrome.

[0223] Patient 14 in Case 14 received moxibustion therapy three times a week for 60 minutes each time, for four consecutive weeks. After four weeks, the patient's mental state was good, and they reported a significant recovery in physical strength. The fatigue that had persisted for several months after COVID-19 was significantly relieved, and their tolerance for daily activities increased, with no significant fatigue or weakness. The hepatic hemangioma was stable, with no enlargement or compression symptoms observed; the total bilirubin level decreased and approached the normal range; hyperlipidemia improved through dietary control and medication. Echocardiography showed that the mitral and tricuspid regurgitation was stable, with no worsening of regurgitation and no significant palpitations, shortness of breath, or other discomfort. Sleep quality further improved, with fewer nighttime awakenings and occasional light sleep that did not affect daytime energy recovery. Appetite was fair, weight was stable, and bowel movements were regular and formed. Tongue examination showed that the tongue had changed from red to pale, and the white, greasy coating had lessened; the pulse was slower but stronger than before, indicating a significant improvement in qi and blood deficiency, and some resolution of dampness and turbidity in the body, with the overall constitution approaching balance.

[0224] As can be seen from the above, after moxibustion treatment with product 14, the patient's "fatigue" symptoms were significantly relieved, the "deficiency of qi and blood" was effectively treated, the sequelae of COVID-19 gradually recovered, and all underlying diseases were under control.

[0225] Case 15

[0226] Mr. Zhang, male, 48 years old, worker, has suffered from stomach pain for several years.

[0227] Present Illness: The patient began experiencing stomach pain several years ago. An external hospital diagnosed him with chronic nonatrophic gastritis with erosion, and multiple polyps in the duodenum and stomach. After treatment with traditional Chinese medicine and acupuncture, he stopped taking bismuth magnesium granules and his bowel movements improved, reflux improved, and his appetite returned to normal.

[0228] No medical history, no history of drug allergies. Physical examination: general condition is fair. Traditional Chinese medicine diagnosis: red tongue with yellow and greasy coating and cracks; slippery pulse on the left and weak pulse on the right.

[0229] Preliminary diagnosis: 1. Stomach pain; 2. Stomach yin deficiency and qi stagnation syndrome; 3. Erosive gastritis.

[0230] Patient 15 in Case 15 received moxibustion treatment three times a week for 40 minutes each time, for four consecutive weeks. After four weeks, the patient's long-term stomach pain symptoms were significantly reduced, with no obvious burning pain or postprandial discomfort, and constipation disappeared. Digestive function improved compared to before. Appetite was fair, meals were regular, and weight was stable. Follow-up examination showed that the chronic non-atrophic gastritis with erosion was stable, and the mucosal repair was good under gastroscopy; the multiple polyps in the duodenum and stomach did not increase in size, and regular follow-up is ongoing. The tongue changed from red to pale, the yellow and greasy coating lessened, and the cracks did not deepen; the pulse on the left was slippery and had eased, while the pulse on the right was weaker but stronger than before, indicating that the stomach yin was gradually recovering, the symptoms of qi stagnation and damp heat were easing, and the circulation of qi and blood was becoming more harmonious.

[0231] As can be seen from the above, after moxibustion treatment with product 15, the patient's "stomach pain" and related TCM syndrome "stomach yin deficiency and qi stagnation syndrome" were significantly relieved, and the condition of erosive gastritis tended to stabilize.

[0232] Case 16

[0233] Sun, male, 52 years old, teacher, suffers from weakness in his lower limbs.

[0234] Present Illness: The patient began experiencing weakness in both lower limbs one year ago, which gradually worsened, making walking difficult and requiring the use of crutches or assistance to move. Initially, symptoms manifested as mild numbness and weakness in the toes, which then gradually spread to the entire lower limbs, severely impacting daily living activities. The patient was diagnosed with "cervical spondylotic myelopathy" at another hospital, but conservative treatment was ineffective. Physical Examination: The patient's general condition is fair, and they are alert. Muscle strength in both upper limbs is normal, while muscle strength in both lower limbs is grade 3. Tendon reflexes are diminished, and pathological reflexes are positive. Traditional Chinese Medicine Diagnosis: The tongue is pale red with a thin white coating; the pulse is thready and weak.

[0235] Preliminary diagnosis: atrophy.

[0236] Symptoms: The main symptoms are weakness in both lower limbs, muscle atrophy, unsteady gait, and frequent falls. The patient reports numbness in the soles of both feet, as if walking on cotton, with a noticeable heaviness. As the condition progresses, the patient develops urinary problems, including urinary frequency and urgency, but without significant dysuria or hematuria.

[0237] Patient 16 in Case 16 received moxibustion treatment via Product 16, once every other day for 60 minutes each time, for four consecutive weeks. After four weeks, the patient's mental state was good, emotions were stable, weakness in both lower limbs was significantly reduced, walking ability was significantly improved, and the patient no longer needed crutches or assistance to walk relatively long distances independently and slowly. Gait was more stable than before, frequency of falls decreased, and balance improved. Muscle atrophy in the lower limbs had recovered somewhat, with muscle strength improving from grade 3 to around grade 4. Tendon reflexes were more active than before, and pathological reflexes were weakened or disappeared. Numbness and heaviness in the soles of the feet were significantly relieved, and sensory function gradually recovered. Urinary disorders were significantly improved, with reduced urinary frequency and urgency, decreased nocturia, improved quality of life, and restoration of normal living abilities. The tongue was pale red with a thin white coating, and the pulse was thready and weak but stronger than before, indicating that qi and blood were gradually replenished, liver and kidney function was recovering, and meridian flow was becoming smoother.

[0238] As can be seen from the above, after moxibustion treatment with product 16, the patient's atrophy was significantly relieved, the strength of the patient's lower limbs was restored, and the patient was able to walk independently for short distances. The nerve function related to cervical spondylosis of the spinal cord type was restored.

[0239] Case 17

[0240] Ms. Liu, 68 years old, retired, suffers from asthma.

[0241] Present Illness: The patient has a history of chronic bronchitis for over ten years, with recurrent episodes of wheezing and dyspnea in the past six months, especially severe at night, accompanied by cough and sputum production; the sputum is thick and difficult to expectorate. Recently, a cold exacerbated the symptoms, resulting in significant shortness of breath, inability to lie flat, and the need to sit up to breathe for relief. Physical Examination: The patient is in poor general condition, exhibiting an orthopneic posture. Widespread wheezing is audible on auscultation of both lungs. The heart rate is tachycardia, and mild pitting edema is present in both lower extremities. Traditional Chinese Medicine Diagnosis: The tongue is dark red with a yellow, greasy coating; the pulse is slippery and rapid.

[0242] Preliminary diagnosis: Asthma, phlegm-heat obstructing the lungs.

[0243] Symptoms: The main symptom is severe shortness of breath, especially at night or in the early morning, often requiring a semi-recumbent or even upright position to alleviate the difficulty breathing. Frequent coughing produces large amounts of thick, yellow sputum, occasionally with traces of blood. Patients experience chest tightness and shortness of breath, which worsens with exertion, and even slight activity leads to shortness of breath and fatigue.

[0244] Patient 17 in Case 17 received moxibustion therapy every other day for 90 minutes each time, for four consecutive weeks. After four weeks, the patient's mental state was good, physical strength recovered, and dyspnea symptoms were significantly relieved. The frequency of nocturnal wheezing attacks decreased significantly, and the patient was able to fall asleep lying flat without significant awakening due to shortness of breath. Severe shortness of breath or chest tightness did not recur after daily activities. Cough frequency decreased, sputum volume decreased, and the sputum changed from thick yellow to thin white, easily expectorated; occasional blood streaks disappeared. Wheezing on auscultation of both lungs significantly decreased, with only occasional dry rales heard after strenuous activity. Heart rate stabilized, and pitting edema in both lower extremities subsided. The tongue changed from dark red to pale red, and the yellow, greasy coating lessened, appearing thin yellow or thin white; the pulse was less slippery and rapid than before, indicating a significant relief of phlegm-heat accumulation in the lungs and improved lung function. Sputum expectoration was smooth, self-care ability improved, and quality of life significantly improved. Recent follow-up pulmonary function tests showed improvement, with no signs of acute infection.

[0245] As can be seen from the above, after moxibustion treatment with product 17, the patient's "asthma" and "phlegm-heat obstructing the lungs" were significantly relieved, the acute exacerbation of chronic bronchitis was effectively controlled, the patient was able to lie flat to rest, the quality of sleep at night improved, the patient's daily activity ability was also restored, and the overall condition was stable.

[0246] The patients in the above cases all underwent long-term hospital treatment and / or other treatments, but their symptoms did not improve significantly. The intractable diseases described in this invention, in addition to the art-related conditions such as arthralgia, atrophy, epilepsy, and asthma, also include hyperthyroidism, chronic insomnia, and chronic gastritis in the cases mentioned in the examples. In this invention, diseases that are difficult to diagnose, have unknown causes, and whose symptoms have not significantly improved after long-term treatment all fall under the category of intractable diseases.

[0247] In addition, statistical analysis showed that for the same symptoms, compared with Examples 1-17, the therapeutic effect of Control Product 1 was significantly less than that of Products 1-17 within the same treatment time. Control Product 1 required a longer treatment time to achieve the therapeutic effect of Products 1-17, indicating that the drug penetration of Products 1-17 was significantly higher than that of Control Product 1. This proves that the combination of Acorus tatarinowii and frankincense can effectively enhance the drug penetration, allowing the drug to act on the lesion site more quickly and shortening the treatment time.

[0248] For the same symptom, compared to Examples 1-17, within the same time period, the therapeutic effect of Control Product 2 was significantly inferior to that of Products 1-17. Furthermore, with increasing treatment time, the improvement in symptoms by Control Product 2 was less than that of Products 1-17 and also less than that of Control Product 1. This indicates that the mass ratio of Acorus tatarinowii to frankincense also affects their compatibility. The improvement of this invention is not merely a simple component substitution, but also involves optimizing the proportions between components. This adjustment plays a crucial role in enhancing the therapeutic effect. By replacing musk with Acorus tatarinowii and correspondingly re-proportioning the components of Acorus tatarinowii, this invention enables the pharmaceutical composition to exhibit superior synergistic effects.

[0249] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, and not to limit them; although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some or all of the technical features; and these modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. A traditional Chinese medicine composition for treating various intractable diseases, characterized in that, The ingredients, by weight, include 30-150 parts of Artemisia argyi, 3-15 parts of Frankincense, 8-12 parts of Acorus tatarinowii, 3-15 parts of Gleditsia sinensis, 5-30 parts of Citrus aurantium, 5-20 parts of Ligusticum chuanxiong, 5-20 parts of Cinnamomum cassia, 5-20 parts of Eucommia ulmoides, 1-3 parts of Buthus martensii, 3-15 parts of Angelica dahurica, 1-3 parts of Asarum heterotropoides, 1-3 parts of Rosin, 1-3 parts of Realgar, 3-15 parts of Angelica pubescens, 1-3 parts of Luffa cylindrica, 3-15 parts of Clove, 3-15 parts of Carthamus tinctorius, 3-15 parts of Taraxacum mongolicum, 3-15 parts of Hedyotis diffusa, 3-15 parts of Scutellaria barbata, 3-15 parts of Rosa rugosa, 3-15 parts of Lobelia chinensis, 3-15 parts of Paeonia lactiflora, 5-12 parts of Bambusa textilis, 5-12 parts of Clematis chinensis, 3-5 parts of Perilla frutescens, 5-12 parts of Bupleurum chinense, and 5-12 parts of Corydalis yanhusuo.

2. The traditional Chinese medicine composition for treating various intractable diseases according to claim 1, characterized in that, The weight ratio of Artemisia argyi, frankincense and Acorus calamus is (40-130):(5-12):(9-11).

3. The traditional Chinese medicine composition for treating various intractable diseases according to claim 1, characterized in that, The weight ratio of soapberry, immature bitter orange, chuanxiong, cinnamon twig and eucommia bark is (5-12):(8-25):(7-18):(7-18):(7-18).

4. The traditional Chinese medicine composition for treating various intractable diseases according to claim 1, characterized in that, The weight ratio of scorpion, angelica, asarum and rosin is (1.5-2.5):(5-12):(1.5-2.5):(1.5-2.5).

5. The traditional Chinese medicine composition for treating various intractable diseases according to claim 1, characterized in that, The weight ratio of realgar, angelica pubescens, loofah sponge and clove is (1.5-2.5):(5-12):(1.5-2.5):(5-12).

6. The traditional Chinese medicine composition for treating various intractable diseases according to claim 1, characterized in that, The mass ratio of safflower, dandelion, white flower snake tongue grass, scutellaria barbata, rose, lobelia chinensis and red peony, by weight, is (5-12):(5-12):(5-12):(5-12):(5-12):(5-12):(5-12):(5-12):(5-12).

7. The traditional Chinese medicine composition for treating various intractable diseases according to claim 1, characterized in that, The mass ratio of bamboo shavings, clematis root, perilla leaf, bupleurum root, and corydalis root, by weight, is (7-10):(7-10):(3.5-4.5):(7-10):(7-10).

8. A method for preparing a traditional Chinese medicine composition for treating various intractable diseases as described in any one of claims 1-7, characterized in that, Includes the following steps: S1: Weigh out the following ingredients according to the specified proportions: Artemisia argyi, frankincense, Acorus tatarinowii, Gleditsia sinensis, Citrus aurantium, Ligusticum chuanxiong, Cinnamomum cassia, Eucommia ulmoides, Buthus martensii, Angelica dahurica, Asarum heterotropoides, Rosin, Realgar, Angelica pubescens, Luffa cylindrica, Clove, Carthamus tinctorius, Taraxacum mongolicum, Hedyotis diffusa, Scutellaria barbata, Rosa rugosa, Lobelia chinensis, Paeonia lactiflora, Bambusa textilis, Clematis chinensis, Perilla frutescens, Bupleurum chinense, and Corydalis yanhusuo. S2: Pulverize the medicinal materials obtained in step S1, mix them evenly, and pass them through a 30-40 mesh sieve to obtain a traditional Chinese medicine composition.

9. The use of a traditional Chinese medicine composition according to any one of claims 1-7 or a traditional Chinese medicine composition prepared by the preparation method according to claim 8 in moxibustion sticks or medicinal bath powder.

10. The application according to claim 9, characterized in that, The preparation method of the moxibustion stick is as follows: add water or binder to the traditional Chinese medicine composition, stir evenly, add the mixture into the moxibustion stick mold, and obtain the moxibustion stick after solidification; The application method of the medicinal bath powder is as follows: add water to the traditional Chinese medicine composition, heat at 80-90℃ for 2-4 hours, filter to obtain the washing solution; the mass ratio of the traditional Chinese medicine composition to sterile water is 1:20-1:50.