Sterile split charging isolator based on fluid system optimization

Abstract

The invention discloses a sterile subpackaging isolator based on fluid system optimization, which comprises a sterile isolator body, a belt conveyor, a filling support and a filling hose, and is characterized in that a capsule accumulating mechanism is arranged at the sterile isolator body configured with a fluid filling system and is connected with a filling needle and the filling hose; a conical-head air bag of the bag accumulating mechanism serves as a fluid temporary storage cavity, residual air in a pipeline is discharged through a waterproof breathable film of the breathable mechanism at the initial stage of fluid filling, fluid is collected into a continuous body in the conical-head air bag and then is filled, and the problems that the amount of a first bottle is small due to gas-liquid mixing, and dispersed residual liquid is collected in the conical-head air bag at the final stage of fluid filling, so that the filling efficiency is low are solved. The pressure fluctuation caused by low liquid level is reduced, the filling stability of a tail bottle is guaranteed, and the problem that the initial and final filling pressure of a fluid filling system in the sterile isolator body is abnormal is effectively solved.

Description

Technical Field

[0001] This invention relates to the field of aseptic dispensing isolators, and in particular to an aseptic dispensing isolator based on fluid system optimization. Background Technology

[0002] A sterile isolator is a completely sealed sterile operating environment created through physical barriers. It aims to minimize or eliminate contamination of internal work objects by external microorganisms and particles, while also protecting operators and the environment from harmful substances (such as biological agents and hazardous microorganisms). It is widely used in pharmaceuticals, bioengineering, medical fields, laboratories, and other areas with extremely high sterility requirements.

[0003] Currently, when the fluid filling system is configured inside the sterile isolator, the fluid will pass through a pipe with a valve body in a large container, along with a peristaltic pump and filling head, to fill the bottles placed on the conveyor belt. After filling, the bottles will be transported to the capping equipment inside the isolator for capping. However, there are problems with abnormal filling volume in the initial and final filling states of this fluid filling system.

[0004] Initially, air may remain in the pipeline, pump chamber, or connecting pipe between the container and the pump. Air is much more compressible than fluid. When the pump starts, the force of the roller squeezing the hose will be used to compress the air first, rather than to push the fluid. This causes the initial pressure to fail to be established effectively, and the fluid is delivered to the filling needle in an "intermittent" manner (gas-liquid mixture), causing the initial filling volume of the first few bottles to deviate from the set value.

[0005] In the final stage, the fluid remaining in the container is small and close to being emptied. The path of the fluid from the container to the pump becomes longer, and the suction resistance increases, causing fluctuations in the filling pressure at the filling needle, which affects the abnormal filling volume of the last few bottles.

[0006] To address the issue of abnormal initial and final filling pressures in the fluid filling system of a sterile isolator, we propose a sterile dispensing isolator based on fluid system optimization. Summary of the Invention

[0007] The main objective of this invention is to provide a sterile dispensing isolator based on fluid system optimization. This invention incorporates a bladder mechanism connecting the dispensing needle and dispensing tubing within the sterile isolator body, which is configured with a fluid filling system. The conical air bladder of the bladder mechanism serves as a fluid storage chamber, and a one-way valve enables unidirectional fluid inflow. During the initial fluid filling stage, residual air in the tubing is first discharged through the waterproof and breathable membrane of the venting mechanism. The fluid then gathers into a continuous flow within the conical air bladder before filling, avoiding insufficient initial volume due to gas-liquid mixing. During the final fluid filling stage, the dispersed residual liquid re-gathers within the conical air bladder, reducing pressure fluctuations caused by low liquid levels and ensuring stable final volume filling. This effectively solves the problem of abnormal initial and final filling pressures within the fluid filling system of the sterile isolator body, thus effectively addressing the issues in the background art.

[0008] To achieve the above objectives, the technical solution adopted by the present invention is as follows:

[0009] A sterile dispensing isolator based on fluid system optimization includes a sterile isolator body, a belt conveyor, a filling rack, and a filling hose. The belt conveyor is installed inside the sterile isolator body, and a filling rack driven by a cylinder is installed inside the sterile isolator body on one side of the belt conveyor. A filling needle is installed on the frame of the filling rack, and a filling hose for fluid filling in conjunction with a peristaltic pump and a material container is installed in the sterile isolator body above the filling rack. The device also includes an accumulation mechanism, a venting mechanism, and a bladder contraction mechanism. An accumulation mechanism for containing fluid is installed between the liquid outlet of the filling hose and the filling needle, and a venting mechanism for venting is installed at the accumulation mechanism. A bladder contraction mechanism for clamping the bladder is installed between the accumulation mechanism below the venting mechanism and the filling rack.

[0010] Furthermore, the filling mechanism includes a mini ball valve, a T-shaped hard sleeve, a conical airbag, a one-way valve, and an exhaust airbag tube. The filling needle and the T-shaped hard sleeve are interconnected by a mini ball valve, and the T-shaped hard sleeve is clamped and bonded to the lower airbag tube of the conical airbag. The upper airbag tube of the conical airbag is interconnected with the filling hose through a one-way valve, and the upper airbag surface of the conical airbag is integrally formed with an exhaust airbag tube for venting.

[0011] By adopting the above-mentioned preferred technical solution, after the T-shaped hard sleeve of the accumulating mechanism is bonded and installed at the lower bladder tube of the conical airbag, it can be connected to the filling needle through a mini ball valve to achieve controllable cutoff of the fluid filling path. The upper bladder tube of the conical airbag is connected to the filling hose through a one-way valve for unidirectional fluid passage. When the fluid below enters the conical airbag in the initial and final states, it can be vented outward through the vent tube.

[0012] Furthermore, a venting mechanism is provided at the upper opening of the exhaust bladder tube, and the venting mechanism includes a rigid branch tube, a waterproof and breathable membrane, a central septum spiral tube, and a sealing cap. The upper opening of the exhaust bladder tube is interconnected with the central septum spiral tube through the rigid branch tube, and a central rib ring for supporting the central septum spiral tube is integrally formed on the inner wall of the rigid branch tube. A waterproof and breathable membrane is press-fitted between the central rib ring and the central septum spiral tube, and a sealing cap for sealing is screwed onto the outer part of the central septum spiral tube protruding from the rigid branch tube.

[0013] By adopting the above-mentioned preferred technical solution, after the rigid branch pipe of the venting mechanism is installed on the outside of the exhaust bladder pipe, the exhaust bladder pipe is connected to the middle diaphragm screw pipe by the rigid branch pipe, and the waterproof and breathable membrane is pressed at the middle rib ring, so that the exhaust bladder pipe can achieve waterproof overflow exhaust. When exhaust is not required, the sealing cap can be screwed onto the rigid branch pipe for sealing.

[0014] Furthermore, the hollow body of the cone-shaped airbag below the exhaust bladder tube is symmetrically provided with fork-clamping grooves on both sides for installing the bladder retraction mechanism. The bladder retraction mechanism includes a movable clamping plate, a fixed clamping plate, a straight frame, an angled fixed plate, a long rod guide bolt, a T-shaped pull plate, and an electric push rod. The movable clamping plate and the fixed clamping plate respectively pass through the double sets of grooves in the fork-clamping groove. The fixed clamping plate is installed at the angled fixed plate welded to the top of the straight frame through the long rod guide bolt. The bolt body of the long rod guide bolt away from the fixed clamping plate moves out of the movable clamping plate. The bottom frame plate of the straight frame is installed on the surface of the filling frame outside the filling needle. A C-shaped bracket for mounting the electric push rod with bolts is welded between the double sets of frame plates of the straight frame. A T-shaped pull plate is installed at the telescopic rod head of the electric push rod. The T-shaped pull plate is inserted between the middle plates of the movable clamping plate and the fixed clamping plate. The tail plate of the T-shaped pull plate abuts against the outside of the plate of the movable clamping plate.

[0015] By adopting the above-mentioned preferred technical solution, the moving clamp plate and the fixed clamp plate of the bladder mechanism pass through the double-set slot cavity of the fork clamp groove respectively. Then, the fixed clamp plate is clamped between the straight bar frame and the corner fixed plate. The straight bar frame can be locked to the surface of the irrigation frame with bolts to obtain support. Then, the seat of the electric push rod can be installed at the C-shaped bracket outside the straight bar frame with bolts. At the same time, the long rod guide bolt is screwed into the fixed clamp plate from the corner fixed plate and finally passes through the moving clamp plate as a guide. Then, the T-shaped pull plate passes through the fixed clamp plate from the moving plate and connects to the telescopic rod head of the electric push rod, which is convenient to be pulled. When the T-shaped pull plate pulls the moving clamp plate close to the fixed clamp plate, the distance between the two plates decreases, and the cone-shaped air bladder can be clamped and deformed, thereby compensating for the pressure of the fluid in the bladder during infusion.

[0016] Furthermore, an angle plate is welded to the top of the straight bar frame, and a fixed clamping plate is fitted into the welding groove between the angle plate and the straight bar frame. An installation hole for unscrewing out a long rod guide bolt is provided between the fixed clamping plate and the angle plate, and the bare rod of the long rod guide bolt passes through the guide hole opened on the surface of the moving clamping plate.

[0017] By adopting the above-mentioned preferred technical solution, after the corner plate is welded to the top of the straight frame, a welding frame groove is formed to position and clamp the fixed plate. Then, the long rod guide bolt can be screwed into the mounting holes of the corner plate and the fixed plate, thereby passing through the guide hole of the moving plate and providing guidance for the moving plate.

[0018] Furthermore, a slot for inserting a T-shaped pull plate is provided between the central frame plate of the fixed clamping plate and the moving clamping plate, and the end plate of the T-shaped pull plate that extends out of the fixed clamping plate is locked with an h-shaped connecting seat that is sleeved outside its own plate body by bolts. An installation hole for screwing bolts is provided between the single end plate of the h-shaped connecting seat and the telescopic rod head of the electric actuator.

[0019] By adopting the above-mentioned preferred technical solution, the strip of the T-shaped pull plate can be inserted into the seat cavity of the h-shaped connecting seat after passing through the slots of the fixed clamping plate and the moving clamping plate. The h-shaped connecting seat and the T-shaped connecting plate can be locked together using bolts. At the same time, the single-ended plate of the h-shaped connecting seat is locked together with the telescopic rod head of the electric actuator using bolts.

[0020] Furthermore, the conical airbag between the fixed clamping plate and the moving clamping plate has tubes integrally formed at both ends, and the upper tube of the conical airbag is connected and clamped to the liquid outlet end of the one-way valve, the liquid inlet end of the one-way valve is connected and clamped to the filling hose, the lower tube of the conical airbag is clamped and bonded to the outside, and the lower end of the threaded tube of the T-shaped hard sleeve is screwed into the liquid inlet of the mini ball valve, and the liquid outlet of the mini ball valve is connected and screwed to the liquid inlet threaded tube of the filling needle.

[0021] By adopting the above-mentioned preferred technical solution, after the upper tube of the cone-shaped airbag is fitted with the one-way valve sleeve, a clamp that is locked with bolts can be used to lock it on the outside of the upper tube of the cone-shaped airbag. After the lower tube of the cone-shaped airbag is glued and fixed with the T-shaped hard sleeve, a mini ball valve can be easily screwed on. The mini ball valve can be screwed on and installed at the filling needle for connection.

[0022] Furthermore, the outer side of the exhaust bladder tube of the cone-shaped airbag is bonded with a rigid branch tube, and the central rib ring inside the rigid branch tube is in contact with the exhaust bladder tube and the waterproof and breathable membrane on both sides respectively. The ring opening of the central rib ring is integrally formed with a support rib, and a central diaphragm spiral tube is spun into the rigid branch tube above the central rib ring and the waterproof and breathable membrane. The central diaphragm spiral tube is integrally formed with a diaphragm rib in the middle of its tube body.

[0023] By adopting the above-mentioned preferred technical solution, after the rigid branch tube is bonded to the outer sleeve of the exhaust bladder tube, the rigid branch tube can be supported by the central rib ring to attach the waterproof and breathable membrane. The waterproof and breathable membrane can be press-fitted into the rigid branch tube by using the central diaphragm screw tube. The ribs of the central diaphragm screw tube can be easily clamped and rotated by tools.

[0024] Furthermore, a sealing cap is screwed onto the outside of the threaded tube body extending above the rigid branch tube of the central diaphragm screw tube, and a slotted handle is integrally formed on the top of the sealing cap body.

[0025] By adopting the above-mentioned preferred technical solution, the cap can be rotated and placed on the outside of the central diaphragm tube by pinching the handle of the cap for sealing.

[0026] Compared with the prior art, the present invention has the following beneficial effects:

[0027] This invention solves the problem of abnormal initial and final filling pressure in the aseptic isolator body of the fluid filling system by setting a bladder mechanism to connect the filling needle and the filling tube. The conical air bladder of the bladder mechanism serves as a fluid storage chamber and, together with a one-way valve, enables unidirectional fluid inflow. In the initial stage of fluid filling, residual air in the pipeline is first discharged through the waterproof and breathable membrane of the venting mechanism. The fluid is collected into a continuous volume in the conical air bladder before filling, avoiding the problem of low volume in the first bottle due to gas-liquid mixing. In the final stage of fluid filling, the dispersed residual liquid is re-collected in the conical air bladder, reducing pressure fluctuations caused by low liquid level and ensuring stable filling of the last bottle. This effectively solves the problem of abnormal initial and final filling pressure in the fluid filling system inside the aseptic isolator body.

[0028] Furthermore, the electric actuator of the bladder compression mechanism drives the moving clamp plate to cooperate with the fixed clamp plate to squeeze the conical air bladder, dynamically adjusting the volume of the bladder. Before the initial filling of the fluid, the normal bladder cavity stores more fluid to offset the compression loss of the air in the pipeline. In the final stage of fluid filling, the bladder cavity can be compressed to force the residual liquid out, compensating for the effect of the decrease in suction resistance, ensuring full utilization of the residual liquid, stabilizing the filling pressure, and improving the accuracy of the last bottle.

[0029] Meanwhile, the venting mechanism can be assembled into a controllable sealing venting structure at the venting tube of the cone-shaped airbag, which facilitates venting of the cone-shaped airbag during the initial and final filling stages of the fluid.

[0030] Moreover, the combined operation of the accumulating mechanism, the venting mechanism, and the accumulating mechanism not only solves the core pain points of initial air resistance and final pressure fluctuation in fluid distribution and filling, but also achieves pressure self-compensation, aseptic compatibility, and process automation through structural innovation, which greatly improves the accuracy, stability, and material utilization of aseptic filling. Attached Figure Description

[0031] Figure 1 This is a schematic diagram of the overall structure of a sterile dispensing isolator based on fluid system optimization according to the present invention.

[0032] Figure 2 This is a schematic diagram showing the disassembly of the accumulating and shrinking mechanisms of the aseptic dispensing isolator based on fluid system optimization according to the present invention at the filling tube, filling needle, and filling rack.

[0033] Figure 3 This invention relates to a sterile dispensing isolator based on fluid system optimization. Figure 2 Enlarged view of a specific area.

[0034] Figure 4 This is a schematic diagram showing the disassembly of the sac-forming mechanism, the filling rack, and the sac-forming mechanism of a sterile dispensing isolator based on fluid system optimization according to the present invention.

[0035] Figure 5 This is a schematic diagram showing the disassembly of the sac-filling mechanism, filling tubing, and filling needle of a sterile dispensing isolator based on fluid system optimization according to the present invention.

[0036] Figure 6 This is an exploded view of the sac accumulation mechanism of a fluid system-optimized aseptic dispensing isolator according to the present invention.

[0037] Figure 7 This is an exploded view of the venting mechanism of a sterile dispensing isolator based on fluid system optimization according to the present invention.

[0038] Figure 8 This is a cross-sectional view of the cone-shaped air bladder of a sterile dispensing isolator based on fluid system optimization according to the present invention.

[0039] Figure 9 This is an exploded view of the bladder mechanism of a sterile dispensing isolator based on fluid system optimization according to the present invention.

[0040] Figure 10 This diagram illustrates the connection positions of the straight shelf, corner plate, and C-shaped bracket of a fluid system-optimized aseptic dispensing isolator according to the present invention.

[0041] In the diagram: 1. Aseptic isolator body; 2. Belt conveyor; 3. Filling rack; 4. Filling needle; 5. Filling hose; 6. Accumulation mechanism; 7. Ventilation mechanism; 8. Retraction mechanism; 9. Mini ball valve; 10. T-shaped rigid sleeve; 11. Conical air bladder; 12. One-way valve; 13. Exhaust bladder tube; 14. Fork clamp groove; 15. Rigid branch pipe; 16. Central rib ring; 17. Waterproof and breathable membrane; 18. Central septum spiral tube; 19. Sealing cap; 20. Moving clamp plate; 21. Fixed clamp plate; 22. Straight bar frame; 23. Angle fixed plate; 24. Long rod guide bolt; 25. T-shaped pull plate; 26. H-shaped connecting seat; 27. Electric push rod; 28. C-shaped bracket. Detailed Implementation

[0042] To make the technical means, creative features, objectives and effects of this invention easier to understand, the invention will be further described below in conjunction with specific embodiments.

[0043] like Figure 1-10As shown, a sterile dispensing isolator based on fluid system optimization includes a sterile isolator body 1, a belt conveyor 2, a filling rack 3, and a filling hose 5. The belt conveyor 2 is installed inside the sterile isolator body 1, and the filling rack 3, which is driven by a cylinder, is installed inside the sterile isolator body 1 on one side of the belt conveyor 2. A filling needle 4 is installed on the frame of the filling rack 3, and a filling hose 5 for fluid filling in conjunction with a peristaltic pump and a material container is installed inside the sterile isolator body 1 above the filling rack 3. The device also includes an accumulation mechanism 6, a venting mechanism 7, and a shrinking mechanism 8. The fluid outlet of the filling hose 5 is interconnected with the filling needle 4 and an accumulation mechanism 6 for containing fluid is installed. A venting mechanism 7 for venting is installed at the accumulation mechanism 6. A shrinking mechanism 8 for clamping the bladder is installed between the accumulation mechanism 6 below the venting mechanism 7 and the filling rack 3.

[0044] The filling mechanism 6 includes a mini ball valve 9, a T-shaped hard sleeve 10, a conical airbag 11, a one-way valve 12, and an exhaust airbag tube 13. The filling needle 4 and the T-shaped hard sleeve 10 are interconnected by the mini ball valve 9, and the T-shaped hard sleeve 10 is clamped and bonded to the lower airbag tube of the conical airbag 11. The upper airbag tube of the conical airbag 11 is interconnected with the filling hose 5 through the one-way valve 12, and the upper airbag surface of the conical airbag 11 is integrally formed with an exhaust airbag tube 13 for exhausting air.

[0045] By adopting the above-mentioned preferred technical solution, after the T-shaped hard sleeve 10 of the accumulating mechanism 6 is bonded and installed at the lower bladder tube of the conical airbag 11, it can be connected to the filling needle 4 through the mini ball valve 9 to achieve controllable cutoff of the fluid filling path. The upper bladder tube of the conical airbag 11 is connected to the filling hose 5 through the one-way valve 12 for unidirectional fluid passage. When the fluid below the initial and final states enters the conical airbag 11, it can be vented outward through the exhaust bladder tube 13.

[0046] The upper opening of the exhaust bladder tube 13 is provided with a ventilation mechanism 7, which includes a rigid branch tube 15, a waterproof and breathable membrane 17, a central diaphragm spiral tube 18, and a sealing cap 19. The upper opening of the exhaust bladder tube 13 is interconnected with the central diaphragm spiral tube 18 through the rigid branch tube 15. The inner wall of the rigid branch tube 15 is integrally formed with a central rib ring 16 for supporting the central diaphragm spiral tube 18. The waterproof and breathable membrane 17 is pressed between the central rib ring 16 and the central diaphragm spiral tube 18. The central diaphragm spiral tube 18 is screwed with a sealing cap 19 for sealing the tube body outside the rigid branch tube 15.

[0047] By adopting the above-mentioned preferred technical solution, after the rigid branch pipe 15 of the ventilation mechanism 7 is installed on the outside of the exhaust bladder pipe 13, the exhaust bladder pipe 13 is connected to the middle diaphragm screw pipe 18 by the rigid branch pipe 15, and the waterproof and breathable membrane 17 is pressed at the middle rib ring 16, so that the exhaust bladder pipe 13 can achieve waterproof overflow exhaust. When exhaust is not required, the sealing cap 19 can be screwed onto the rigid branch pipe 15 for sealing.

[0048] The hollow bladder body of the cone-shaped airbag 11 below the exhaust bladder pipe 13 is symmetrically provided with fork-clamping grooves 14 for installing the bladder-shrinking mechanism 8. The bladder-shrinking mechanism 8 includes a movable clamping plate 20, a fixed clamping plate 21, a straight frame 22, an angled fixed plate 23, a long rod guide bolt 24, a T-shaped pull plate 25, and an electric push rod 27. The movable clamping plate 20 and the fixed clamping plate 21 respectively extend from the double-set groove cavities of the fork-clamping groove 14. The fixed clamping plate 21 is installed at the angled fixed plate 23 welded to the top of the straight frame 22 via the long rod guide bolt 24. The guide bolt 24 moves away from the fixed clamp plate 21 and passes through the movable clamp plate 20. The base plate of the straight frame 22 is installed on the surface of the filling needle 4 outside the filling frame 3. A C-shaped bracket 28 for mounting the electric push rod 27 with bolts is welded between the two sets of frame plates of the straight frame 22. A T-shaped pull plate 25 is installed at the telescopic rod head of the electric push rod 27. The T-shaped pull plate 25 is inserted between the middle plate of the movable clamp plate 20 and the fixed clamp plate 21. The tail plate of the T-shaped pull plate 25 abuts against the outside of the plate of the movable clamp plate 20.

[0049] By adopting the above-mentioned preferred technical solution, the movable clamping plate 20 and the fixed clamping plate 21 of the bladder mechanism 8 pass through the double set of slots in the fork clamping groove 14 respectively. Then, the fixed clamping plate 27 is clamped between the straight bar frame 22 and the corner fixed plate 23. The straight bar frame 22 can be locked to the surface of the irrigation frame 3 with bolts to obtain support. Then, the seat of the electric push rod 27 can be installed at the C-shaped bracket 28 outside the straight bar frame 22 with bolts. At the same time, the long rod guide bolt 24 is screwed into the fixed clamping plate 21 from the corner fixed plate 23 and finally passes through the movable clamping plate 20 as a guide. Then, the T-shaped pull plate 25 passes through the fixed clamping plate 21 from the movable and fixed plates 20 and is connected to the telescopic rod head of the electric push rod 27 for easy pulling. When the T-shaped pull plate 25 pulls the movable clamping plate 20 close to the fixed clamping plate 21, the distance between the two plates decreases, and the cone-shaped airbag 11 can be clamped and deformed to compensate for the pressure of the fluid in the bladder during infusion.

[0050] The top of the straight frame 22 is welded with an angle plate 23, and a fixed clamping plate 21 is installed in the welding frame groove between the angle plate 23 and the straight frame 22. An installation hole for unscrewing the long rod guide bolt 24 is provided between the fixed clamping plate 21 and the angle plate 23, and the bare rod of the long rod guide bolt 24 passes through the guide hole opened on the surface of the moving clamping plate 20.

[0051] By adopting the above-mentioned preferred technical solution, after the corner plate 23 is welded to the top of the straight frame 22, a welding frame groove is formed to position and clamp the fixed clamp plate 21. Then, the long rod guide bolt 24 can be screwed into the mounting holes of the corner plate 23 and the fixed clamp plate 21, thereby passing through the guide hole of the moving clamp plate 20 and providing guidance for the moving clamp plate 20.

[0052] Among them, a slot for inserting T-shaped pull plate 25 is provided between the central frame plate of the fixed clamping plate 21 and the moving clamping plate 20, and the T-shaped pull plate 25 extends out of the end plate of the fixed clamping plate 21 and is locked with an h-shaped connecting seat 26 that is sleeved outside its own plate body by bolts. An installation hole for screwing bolts is provided between the single end plate of the h-shaped connecting seat 26 and the telescopic rod head of the electric push rod 27.

[0053] By adopting the above-mentioned preferred technical solution, the strip of the T-shaped pull plate 25 can be inserted into the seat cavity of the h-shaped connecting seat 26 after passing through the slots of the fixed clamping plate 21 and the movable clamping plate 20. The h-shaped connecting seat 26 and the T-shaped connecting plate 25 can be locked together using bolts. At the same time, the single-ended plate of the h-shaped connecting seat 26 is locked together with the telescopic rod head of the electric push rod 27 using bolts.

[0054] The conical airbag 11 between the fixed clamping plate 21 and the movable clamping plate 20 has tubes integrally formed at both ends. The upper tube of the conical airbag 11 is connected and clamped to the liquid outlet end of the one-way valve 12. The liquid inlet end of the one-way valve 12 is connected and clamped to the filling hose 5. The lower tube of the conical airbag 11 is clamped and bonded to the outside. The lower threaded tube of the T-shaped hard sleeve 10 is screwed into the liquid inlet of the mini ball valve 9. The liquid outlet of the mini ball valve 9 is connected and screwed to the liquid inlet threaded tube of the filling needle 4.

[0055] By adopting the above-mentioned preferred technical solution, after the upper tube of the conical airbag 11 is inserted into the one-way valve 12, a clamp that is locked with bolts can be used to lock the upper tube of the conical airbag 11. After the lower tube of the conical airbag 11 is glued and fixed to the T-shaped hard sleeve 10, the mini ball valve 9 can be easily screwed on. The mini ball valve 9 can be screwed on and installed at the filling needle 4 for connection.

[0056] Among them, the outer side of the exhaust bladder tube 13 of the cone-shaped airbag 11 is fitted with a rigid branch tube 15, and the central rib ring 16 inside the rigid branch tube 15 is in contact with the exhaust bladder tube 13 and the waterproof and breathable membrane 17 on both sides respectively. The ring opening of the central rib ring 16 is integrally formed with a support rib, and the rigid branch tube 15 above the central rib ring 16 and the waterproof and breathable membrane 17 is spun with a central diaphragm spiral tube 18. The middle part of the tube body of the central diaphragm spiral tube 18 is integrally formed with a diaphragm rib.

[0057] By adopting the above-mentioned preferred technical solution, after the outer sleeve of the exhaust bladder tube 13 is bonded to the rigid branch tube 15, the rigid branch tube 15 can be supported by the central rib ring 16 to support the waterproof and breathable membrane 17. The waterproof and breathable membrane 17 can be pressed into the rigid branch tube 15 by using the central diaphragm screw tube 18. The ribs of the central diaphragm screw tube 18 are convenient to be clamped and rotated by tools.

[0058] Among them, the threaded tube body of the central diaphragm 18 extending above the rigid branch tube 15 is screwed with a sealing cap 19, and the top of the sealing cap 19 is integrally formed with a straight handle.

[0059] By adopting the above-mentioned preferred technical solution, the handle of the sealing cap 19 can be pinched and rotated to fit the outer side of the central diaphragm screw tube 18 for sealing.

[0060] It should be noted that this invention is a sterile dispensing isolator based on fluid system optimization. By setting a bladder mechanism 6 at the sterile isolator body 1 with a fluid filling system to connect the filling needle 4 and the filling tubing 5, the T-shaped hard sleeve 10 of the bladder mechanism 6 is bonded and installed at the lower bladder tube of the conical air bladder 11. Then, the T-shaped hard sleeve 10 is screwed and installed with a mini ball valve 9. At the same time, the mini ball valve 9 can be screwed and installed at the filling needle 4. The filling needle 4 can be normally clamped and screwed at the filling support frame 3 using a clamping structure. After the upper tube of the conical air bladder 11 is inserted with the one-way valve 12, a clamping sleeve can be used to lock it on the outside of the upper tube of the conical air bladder 11 using bolts. Similarly, after the inlet tube of the one-way valve 12 is inserted with the filling tubing 5, a clamping sleeve can also be used to lock it on the outside of the filling tubing 5 using bolts.

[0061] After the rigid branch tube 15 of the ventilation mechanism 7 is attached to the outside of the exhaust bladder tube 13, the waterproof and breathable membrane 17 can be supported by tweezers by inserting it into the central rib ring 16 of the rigid branch tube 15. Similarly, the waterproof and breathable membrane 17 can be removed by tweezers for easy replacement. Then, the central diaphragm screw tube 18 can be screwed into the rigid branch tube 15 and the waterproof and breathable membrane 17 can be pressed into the central rib ring 16. Then, the outer side of the central diaphragm screw tube 18 can be screwed on and the sealing cap 19 can be installed.

[0062] The movable clamping plate 20 and fixed clamping plate 21 of the venting mechanism 7 are inserted into the fork clamping groove 14 of the conical airbag 11. The fixed clamping plate 27 is clamped between the straight bar frame 22 and the angle fixed plate 23. Then, the long rod guide bolt 24 is screwed into the mounting holes of the angle fixed plate 23 and the fixed clamping plate 21, so that the long rod guide bolt 24 passes through the guide hole of the movable clamping plate 20, providing motion guidance for the movable clamping plate 20. The straight bar frame 22 is secured to the surface of the irrigation bracket 3 by bolts. Then, the C-shaped bracket 28 outside the straight bar frame 22 can be... The seat of the electric actuator 27 is installed with bolts. The strip of the T-shaped pull plate 25 passes through the slots of the fixed clamping plate 21 and the movable clamping plate 20 and can be inserted into the seat cavity of the h-shaped connecting seat 26. The h-shaped connecting seat 26 and the T-shaped connecting plate 25 can be locked together with bolts. At the same time, the single-ended plate of the h-shaped connecting seat 26 is locked together with the telescopic rod head of the electric actuator 27 in the extended state with bolts. The electric actuator 27 can be electrically connected to the controller of the sterile isolator body 1 for wiring control.

[0063] When the filling container is placed on the surface of the belt conveyor 2 and conveyed to below the filling needle 4, a photoelectric sensor can be installed inside the aseptic isolator body 1 to monitor the position of the bottle and the height of the liquid inside. When the fluid filling system is in the initial filling state, a technician can unscrew the cap 19 through the aseptic operating gloves of the aseptic isolator body 1, and then manually operate the mini ball valve 9 to close it. The peristaltic pump, in conjunction with the filling hose 5, can deliver fluid from the discharge position below the container. When the fluid is delivered through an air-containing pipe into the conical air bladder 11, the gas inside the bladder can... The fluid is discharged from the waterproof and breathable membrane 17, while the fluid in the initial filling state is collected in the cone-shaped air bladder 11. At this time, the peristaltic pump can be paused and the sealing cap 19 can be screwed back on to stop the air permeation. After the air permeation is stopped, the peristaltic pump can be restarted and the mini ball valve 9 can be opened simultaneously, so that the fluid in the cone-shaped air bladder 11 enters the filling needle 4 through the mini ball valve 9 to fill the bottle container. This avoids the small amount of fluid and gas in the initial state affecting the initial filling volume of the fluid. The mini ball valve 9 here can be replaced with an electrically controlled liquid valve for convenient and rapid response control.

[0064] After the bottle container is filled, the liquid level is detected by the photoelectric sensor, and then the filling stops. The bottle container can be sent by the belt conveyor 2 to the capping device configured in the sterile isolator body 1 for capping, or it can be capped manually. After the bottle container is filled and capped, it can be sent to the subsequent processing steps for disinfection and packaging.

[0065] When the fluid filling system is in its final state, the liquid in the filling tube 5 gradually decreases. The liquid outlet at the filling needle 4 can be cut off by using the mini ball valve 9 or the electric hydraulic valve, and the sealing cap 19 can be unscrewed to restore ventilation. At this time, the residual fluid in the filling tube 5 can be collected in the cone-shaped air bladder 11 until it is full. Then, the filling of the filling needle 4 can be resumed and the ventilation line can be resealed. This allows the fluid to be discharged and collected together, thus facilitating the fluid to be well filled into the container on the surface of the belt conveyor 2. This effectively solves the problem of abnormal initial and final filling pressure of the fluid filling system inside the sterile isolator body 1.

[0066] During final filling, the electric push rod 27 can drive the T-shaped pull plate 25 to pull the movable clamping plate 20 close to the fixed clamping plate 21, thereby squeezing the conical airbag 11. This allows the conical airbag 11 to quickly squeeze out the residual fluid after being pressurized. In the initial state of fluid filling, the conical airbag 11 can also be squeezed to change the chamber of the conical airbag 11, making it easier to adjust the amount of fluid collected. After the electric push rod 27 extends, the distance between the movable clamping plate 20 and the fixed clamping plate 21 increases, and the conical airbag 11 can elastically recover.

[0067] The sealing cap 19 screwed onto the central diaphragm 17 can be screwed onto and installed with an electric air valve, which is convenient to be controlled as needed in conjunction with the controller of the sterile isolator body 1.

[0068] When the container on the surface of the belt conveyor 2 is filled with a fluid filling system equipped with a sac accumulation mechanism 6, a venting mechanism 7 and a sac contraction mechanism 8, it can be filled and debugged multiple times and the data can be recorded. This allows technicians to operate the fluid filling system and the controller of the sterile isolator body 1 to achieve good control of fluid distribution and filling.

[0069] It should be noted that the present invention is a sterile dispensing isolator based on fluid system optimization. All components in the present invention are known to those skilled in the art, and their structure and principle can be learned by those skilled in the art through technical manuals or conventional experimental methods.

[0070] The foregoing has shown and described the basic principles, main features, and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited to the above embodiments. The embodiments and descriptions in the specification are merely illustrative of the principles of the invention. Various changes and modifications can be made to the invention without departing from its spirit and scope, and all such changes and modifications fall within the scope of the present invention as claimed. The scope of protection of this invention is defined by the appended claims and their equivalents.

Claims

1. A sterile dispensing isolator based on fluid system optimization, comprising a sterile isolator body (1), a belt conveyor (2), a filling rack (3), and a filling hose (5), wherein the belt conveyor (2) is installed inside the sterile isolator body (1), and the filling rack (3), which is driven by a cylinder, is installed inside the sterile isolator body (1) on one side of the belt conveyor (2), a filling needle (4) is installed on the frame of the filling rack (3), and a filling hose (5) for fluid filling in conjunction with a peristaltic pump and a material container is installed inside the sterile isolator body (1) above the filling rack (3), characterized in that: It also includes a bladder filling mechanism (6), a venting mechanism (7), and a bladder shrinking mechanism (8). The bladder filling mechanism (6) for containing fluid is installed between the outlet of the filling hose (5) and the filling needle (4), and a venting mechanism (7) for venting is installed at the bladder filling mechanism (6). A bladder shrinking mechanism (8) for clamping the bladder is installed between the bladder filling mechanism (6) below the venting mechanism (7) and the filling support frame (3).

2. The aseptic dispensing isolator based on fluid system optimization according to claim 1, characterized in that: The filling mechanism (6) includes a mini ball valve (9), a T-shaped hard sleeve (10), a cone-shaped airbag (11), a one-way valve (12), and an exhaust tube (13). The filling needle (4) and the T-shaped hard sleeve (10) are interconnected by the mini ball valve (9), and the T-shaped hard sleeve (10) is clamped and bonded to the lower airbag tube of the cone-shaped airbag (11). The upper airbag tube of the cone-shaped airbag (11) is interconnected with the filling hose (5) through the one-way valve (12), and the upper airbag surface of the cone-shaped airbag (11) is integrally formed with an exhaust tube (13) for exhaust.

3. The aseptic dispensing isolator based on fluid system optimization according to claim 2, characterized in that: The upper opening of the exhaust bladder tube (13) is provided with a ventilation mechanism (7), and the ventilation mechanism (7) includes a rigid branch tube (15), a waterproof and breathable membrane (17), a central septum spiral tube (18), and a sealing cap (19). The upper opening of the exhaust bladder tube (13) is interconnected with the central septum spiral tube (18) through the rigid branch tube (15), and the inner wall of the rigid branch tube (15) is integrally formed with a central rib ring (16) for supporting the central septum spiral tube (18). The waterproof and breathable membrane (17) is pressed between the central rib ring (16) and the central septum spiral tube (18), and the central septum spiral tube (18) protruding from the tube body of the rigid branch tube (15) is screwed with a sealing cap (19) for sealing.

4. The aseptic dispensing isolator based on fluid system optimization according to claim 3, characterized in that: The hollow bladder of the cone-shaped airbag (11) below the exhaust bladder pipe (13) is symmetrically provided with fork-clamping grooves (14) on both sides for installing the bladder shrinking mechanism (8). The bladder shrinking mechanism (8) includes a movable clamping plate (20), a fixed clamping plate (21), a straight frame (22), an angled fixed plate (23), a long rod guide bolt (24), a T-shaped pull plate (25), and an electric push rod (27). The movable clamping plate (20) and the fixed clamping plate (21) respectively pass through the double-set groove cavity of the fork-clamping groove (14). The fixed clamping plate (21) is installed at the angled fixed plate (23) welded to the top of the straight frame (22) through the long rod guide bolt (24). The long rod guide bolt (24) moves away from the fixed clamp plate (21) and passes through the moving clamp plate (20). The bottom frame plate of the straight frame (22) is installed on the surface of the filling needle (4) outside the filling frame (3). A C-shaped bracket (28) for mounting the electric push rod (27) with bolts is welded between the two sets of frame plates of the straight frame (22). A T-shaped pull plate (25) is installed at the telescopic rod head of the electric push rod (27). The T-shaped pull plate (25) is inserted between the moving clamp plate (20) and the central plate of the fixed clamp plate (21). The tail plate of the T-shaped pull plate (25) abuts against the outside of the plate of the moving clamp plate (20).

5. A sterile dispensing isolator based on fluid system optimization according to claim 4, characterized in that: An angle plate (23) is welded to the top of the straight frame (22), and a fixed clamping plate (21) is installed in the welding frame groove between the angle plate (23) and the straight frame (22). An installation hole for unscrewing the long rod guide bolt (24) is provided between the fixed clamping plate (21) and the angle plate (23), and the bare rod of the long rod guide bolt (24) passes through the guide hole opened on the surface of the moving clamping plate (20).

6. A sterile dispensing isolator based on fluid system optimization according to claim 5, characterized in that: A slot for inserting a T-shaped pull plate (25) is provided between the central frame plate of the fixed clamping plate (21) and the moving clamping plate (20). The end plate of the T-shaped pull plate (25) is locked with an h-shaped connecting seat (26) that is sleeved outside its own plate body by bolts. An installation hole for screwing bolts is provided between the single end plate of the h-shaped connecting seat (26) and the telescopic rod head of the electric push rod (27).

7. A sterile dispensing isolator based on fluid system optimization according to claim 6, characterized in that: The conical airbag (11) between the fixed clamping plate (21) and the movable clamping plate (20) has tubes integrally formed at both ends. The upper tube of the conical airbag (11) is connected to the outlet tube of the one-way valve (12). The inlet tube of the one-way valve (12) is connected to the filling hose (5). The lower tube of the conical airbag (11) is connected to the outer side of the tube with a T-shaped hard sleeve (10). The lower end of the threaded tube of the T-shaped hard sleeve (10) is screwed into the inlet valve of the mini ball valve (9). The outlet valve of the mini ball valve (9) is connected to the inlet threaded tube of the filling needle (4).

8. A sterile dispensing isolator based on fluid system optimization according to claim 7, characterized in that: The outer side of the exhaust bladder tube (13) of the cone-shaped airbag (11) is fitted with a rigid branch tube (15), and the central rib ring (16) inside the rigid branch tube (15) is in contact with the exhaust bladder tube (13) and the waterproof and breathable membrane (17) on both sides respectively. The ring opening of the central rib ring (16) is integrally formed with a support rib, and the rigid branch tube (15) above the central rib ring (16) and the waterproof and breathable membrane (17) is spun with a central septum spiral tube (18), and the middle part of the tube body of the central septum spiral tube (18) is integrally formed with a rib.

9. A sterile dispensing isolator based on fluid system optimization according to claim 8, characterized in that: The central diaphragm (18) extends out of the threaded tube body above the rigid branch tube (15) and is screwed with a sealing cap (19), and the top of the sealing cap (19) is integrally formed with a handle.

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