Biological freeze-drying isolation system

Abstract

The utility model discloses a biological freeze-drying isolation system which comprises a sterile isolator body, an observation window and an operation window, the observation window is installed at the position of a machine box of the sterile isolator body, the operation window is formed in the surface of a window body of the observation window, and the biological freeze-drying isolation system further comprises an inner sealing mechanism. The inner sealing mechanism comprises an operation pipe, a ring disc, a U-shaped connecting plate, an arc connecting plate, a U-shaped baffle, a U-shaped wrapping strip, a limiting seat and a supporting bolt, and the pipe body used for installing the glove assembly at the operation window of the sterile isolator body is improved into the inner sealing mechanism; an operation tube, a U-shaped connecting plate and a U-shaped baffle plate of the inner sealing mechanism are assembled at an operation window to form a structure capable of conveniently sealing the tube in the sterile isolator body, and the U-shaped baffle plate can clamp and seal the operation tube after losing support, so that a glove cover is not needed when a glove assembly of the sterile isolator body needs to be replaced; and the operation tube can be directly plugged at the sterile isolator body, so that the glove assembly can be conveniently replaced.

Description

Technical Field

[0001] This utility model relates to the field of biological freeze-drying isolation technology, and in particular to a biological freeze-drying isolation system. Background Technology

[0002] Biological freeze-drying, also known as vacuum freeze-drying or simply freeze-drying, is a drying method that removes moisture by freezing water-containing substances at low temperatures and then sublimating the ice directly into gas in a vacuum environment. During the biological freeze-drying process, a sterile isolator is used to connect the freeze dryer to form a freeze-drying isolation system. The operator opens the movable door between the sterile isolator and the freeze dryer to transfer the biological freeze-dried sample from the transfer chamber of the sterile isolator into the freeze dryer for sterile freeze-drying. After freeze-drying, the sample is also removed from the freeze dryer through the sterile isolator.

[0003] Currently, when using sterile isolators to freeze-dry biological samples in biological freeze-drying isolation systems, technicians typically install glove assemblies at the operating window of the sterile isolator for sample production. Replacing these glove assemblies requires first inserting the glove cover into the isolator, then using another glove assembly to clip the cover onto the operating window, and finally pulling the replacement glove assembly out of the operating window. This makes component replacement inconvenient in biological freeze-drying isolation systems. Therefore, we propose a biological freeze-drying isolation system. Utility Model Content

[0004] The main objective of this invention is to provide a biological freeze-drying isolation system. By modifying the tube for installing the glove assembly at the operating window of the sterile isolator body into an internal sealing mechanism, the operating tube, U-shaped connecting plate, and U-shaped baffle of the internal sealing mechanism are assembled at the operating window to form a structure that allows for convenient sealing within the sterile isolator body. The U-shaped baffle can lock the operating tube after losing support, so that when the sterile isolator body needs to replace the glove assembly, there is no need to use a glove cover. The glove assembly can be conveniently replaced by directly sealing the operating tube at the sterile isolator body, which can effectively solve the problems in the background art.

[0005] To achieve the above objectives, the technical solution adopted by this utility model is as follows:

[0006] A biological freeze-drying isolation system includes a sterile isolator body, an observation window, and an operation window. The observation window is installed in the chassis of the sterile isolator body, and an operation window is formed on the surface of the observation window. The system also includes an inner sealing mechanism, which comprises an operation tube, a ring disc, a U-shaped connecting plate, an arc connecting plate, a U-shaped baffle, a U-shaped strip, a limiting seat, and a support bolt. An operation tube is inserted into the operation window, and a ring disc is fixed to the outer opening of the operation tube. The ring disc is adhered and fixed to the surface of the observation window. The operating tube passes through the observation window and is secured to an arc-shaped connecting plate by bolts. A U-shaped connecting plate is fixed to one side of the arc-shaped connecting plate. A U-shaped vertical groove is vertically formed on the U-shaped connecting plate. The circular slot of the U-shaped vertical groove communicates with the operating tube. A pair of limiting seats are symmetrically fixed to the top of the U-shaped connecting plates on both sides of the U-shaped vertical groove. A U-shaped baffle is inserted between the limiting seats and the U-shaped vertical groove. A U-shaped wrapping strip is wrapped around the edge of the U-shaped baffle. A through-stop hole for inserting a support bolt is formed between the U-shaped baffle and the arc-shaped connecting plate.

[0007] Furthermore, the U-shaped vertical groove has circular cavities on both sides of the U-shaped connecting plate at the circular groove hole, and the diameter of the circular cavity of the U-shaped connecting plate is the same as the diameter of the operating tube cavity.

[0008] By adopting the above technical solution, the U-shaped connecting plate communicates with the U-shaped vertical groove and the operating tube through the circular cavity, which facilitates the glove assembly used in the sterile isolator body to pass through the operating tube and the U-shaped connecting plate for biological freeze-drying isolation operation.

[0009] Furthermore, the inner arc plate surface of the arc connecting plate is pressed against the upper part of the operating tube, and bolts are symmetrically screwed between the arc-shaped plate of the arc connecting plate and the operating tube.

[0010] By adopting the above technical solution, after the arc connecting plate is stuck above the operating tube, it can be locked to the operating tube with bolts to obtain support.

[0011] Furthermore, a U-shaped inner groove is recessed in the inner wall of the U-shaped vertical groove, and a U-shaped wrapping strip is inserted into the U-shaped inner groove of the U-shaped vertical groove;

[0012] By adopting the above technical solution, the U-shaped vertical groove can accommodate the U-shaped strip with the U-shaped inner groove, ensuring that the U-shaped baffle can press the U-shaped strip into the U-shaped inner groove for sealing connection.

[0013] Furthermore, the surface of the arc connecting plate has a raised bump, and a through-stop hole is provided between the raised bump of the arc connecting plate and the U-shaped connecting plate.

[0014] By adopting the above technical solution, the through-hole between the convex bulge of the arc connecting plate and the U-shaped connecting plate can accommodate the insertion of the support bolt.

[0015] Furthermore, the length of the branch bolt is greater than the depth of the through hole, and the branch bolt has an adhesive ridge bonded to its body.

[0016] By adopting the above technical solution, after the bolt body passes through the stop hole, the bolt can be firmly inserted into the stop hole with the rubber edge and protrude outward, making it convenient for operators to remove and dismantle the bolt.

[0017] Compared with the prior art, the present invention has the following beneficial effects:

[0018] This utility model improves the tube for installing the glove assembly at the operation window of the sterile isolator body into an internal sealing mechanism. The operation tube, U-shaped connecting plate and U-shaped baffle of the internal sealing mechanism are assembled at the operation window to form a structure that can be conveniently sealed inside the sterile isolator body. The U-shaped baffle can lock the operation tube after losing support, so that when the sterile isolator body needs to replace the glove assembly, there is no need to use the glove cover. The operation tube can be directly sealed at the sterile isolator body for convenient replacement of the glove assembly.

[0019] Furthermore, the U-shaped baffle is supported by a bolt at the U-shaped connecting plate of the inner sealing mechanism. The bolt is easy to insert at the arc connecting plate and the U-shaped connecting plate, which makes the U-shaped baffle effectively supported and prevents it from falling. At the same time, the bolt is easy to pull out, which also facilitates the lowering and sealing operation of the U-shaped baffle. Attached Figure Description

[0020] Figure 1 This is a schematic diagram of the overall structure of a biological freeze-drying isolation system according to the present invention.

[0021] Figure 2 This is a schematic diagram showing the internal sealing mechanism and operation window of a biological freeze-drying isolation system according to this utility model.

[0022] Figure 3 This is an exploded view of the inner sealing mechanism of a biological freeze-drying isolation system according to this utility model.

[0023] In the diagram: 1. Aseptic isolator body; 2. Observation window; 3. Operation window; 4. Inner sealing mechanism; 5. Operation tube; 6. Ring plate; 7. U-shaped connecting plate; 8. Arc connecting plate; 9. U-shaped vertical groove; 10. U-shaped baffle; 11. U-shaped wrapping strip; 12. Limiting seat; 13. Through hole; 14. Support bolt; 15. Glue edge. Detailed Implementation

[0024] To make the technical means, creative features, objectives and effects of this utility model easier to understand, the present utility model will be further described below in conjunction with specific embodiments.

[0025] like Figure 1-3As shown, a biological freeze-drying isolation system includes a sterile isolator body 1, an observation window 2, and an operation window 3. The observation window 2 is installed in the chassis of the sterile isolator body 1, and the operation window 3 is opened on the surface of the observation window 2. It also includes an inner sealing mechanism 4, which includes an operation tube 5, a ring disc 6, a U-shaped connecting plate 7, an arc connecting plate 8, a U-shaped baffle 10, a U-shaped wrapping strip 11, a limiting seat 12, and a support bolt 14. The operation tube 5 is inserted into the operation window 3, and the ring disc 6 is fixed to the outer opening of the operation tube 5. The disc body of the ring disc 6 is bonded and fixed to the surface of the observation window 2. The operating tube 5 passes through the observation window 2 and is bolted to an arc connecting plate 8. A U-shaped connecting plate 7 is fixed to one side of the arc connecting plate 8. A U-shaped vertical groove 9 is vertically opened on the plate of the U-shaped connecting plate 7. The circular groove hole of the U-shaped vertical groove 9 communicates with the operating tube 5. A limiting seat 12 is symmetrically fixed to the top of the U-shaped connecting plate 7 on both sides of the U-shaped vertical groove 9. A U-shaped baffle 10 is inserted between the limiting seat 12 and the U-shaped vertical groove 9. A U-shaped wrapping strip 11 is wrapped around the edge of the U-shaped baffle 10. A through-stop hole 13 for inserting the support bolt 14 is opened between the U-shaped baffle 10 and the arc connecting plate 8.

[0026] Among them, the U-shaped vertical groove 9 has a circular cavity hole on both sides of the U-shaped connecting plate 7 at the circular groove hole, and the diameter of the circular cavity hole of the U-shaped connecting plate 7 is the same as the diameter of the cavity of the operating tube 5.

[0027] By adopting the above technical solution, the U-shaped connecting plate 7 communicates with the U-shaped vertical groove 9 and the operating tube 5 through the circular cavity, so that the glove assembly used in the sterile isolator body 1 can pass through the operating tube 5 and the U-shaped connecting plate 7 to carry out biological freeze-drying isolation operation.

[0028] The inner arc plate surface of the arc connecting plate 8 is pressed against the upper part of the tube body of the operating tube 5, and bolts are symmetrically screwed between the arc plate body of the arc connecting plate 8 and the operating tube 5.

[0029] By adopting the above technical solution, after the arc connecting plate 8 is clamped above the operating tube 5, the arc connecting plate 8 can be locked at the operating tube 5 with bolts to obtain support.

[0030] The U-shaped vertical groove 9 has a U-shaped inner groove recessed in the inner wall, and a U-shaped wrapping strip 11 is inserted into the U-shaped inner groove of the U-shaped vertical groove 9.

[0031] By adopting the above technical solution, the U-shaped vertical groove 9 can accommodate the U-shaped wrapping strip 11 with the U-shaped inner groove, ensuring that the U-shaped baffle 10 can press the U-shaped wrapping strip 11 into the U-shaped inner groove for sealing connection.

[0032] The surface of the arc connecting plate 8 has a raised bump, and a through hole 13 is provided between the raised bump of the arc connecting plate 8 and the U-shaped connecting plate 7.

[0033] By adopting the above technical solution, the through hole 13 opened between the convex bulge of the arc connecting plate 8 and the U-shaped connecting plate 7 can accommodate the insertion of the support bolt 14.

[0034] Wherein, the length of the bolt body of the branch bolt 14 is greater than the depth of the cavity of the stop hole 13, and the bolt body of the branch bolt 14 is bonded with an adhesive ridge 15.

[0035] By adopting the above technical solution, after the bolt body of the bolt 14 passes through the stop hole 13, the bolt 14 can be firmly inserted into the stop hole 13 with the rubber rib 15 and extend outward, making it convenient for operators to remove and dismantle the bolt 14.

[0036] It should be noted that this utility model is a biological freeze-drying isolation system. By modifying the tube for installing the glove assembly at the operating window 3 of the aseptic isolator body 1 into an inner sealing mechanism 4, when the aseptic isolator body 1 is connected to the freeze dryer for biological freeze-drying production, the operating tube 5 of the inner sealing mechanism 4 can pass through the operating window 3. Then, the ring plate 6 of the operating tube 5 can be glued and fixed outside the observation window 2. At the same time, the tube body of the operating tube 5 passing through the operating window 3 can press the arc connecting plate 8. After the arc connecting plate 8 is locked outside the operating tube 5 with bolts, the arc connecting plate 8 can provide effective support for the U-shaped connecting plate 7. Meanwhile, the U-shaped connecting plate 7 communicates with the operating tube 5 through the U-shaped vertical groove 9. The glove assembly required by the aseptic isolator body 1 can be fitted outside the ring plate 6, and then the glove assembly is tightened outside the ring plate 6 using an elastic hoop. Then, the U-shaped baffle 10 is pulled upward from the U-shaped vertical groove 9 into the limiting seat 12. The operating bolt 14 passes through the stop hole 13 of the U-shaped connecting plate 7 and the arc connecting plate 8 to provide support for the U-shaped baffle 10. The glove assembly can pass through the operating tube 5 and the U-shaped connecting plate 7 to enter the sterile isolator body 1 to operate the biological freeze-dried sample for isolation. When the sterile isolator body 1 needs to replace the glove assembly, pull the glove assembly outward away from the operating tube 5, and pull out the stop hole 13 from the other glove assembly. Then the U-shaped baffle 10 with the U-shaped wrapping strip 11 can fall down, so that the U-shaped baffle 10 and the U-shaped wrapping strip 11 seal the operating tube 5 in the U-shaped vertical groove 9. Then the glove assembly can be removed from the ring plate 6. Then reinstall the glove assembly according to the above steps. Then pull the U-shaped baffle 10 upward again into the limiting seat 12, re-insert the bolt 14 to support the U-shaped baffle 10, and then the glove assembly can be sent into the sterile isolator body 1 for normal use.

[0037] It should be noted that this utility model is a biological freeze-drying isolation system. All components in this utility model are known to those skilled in the art, and their structure and principle can be learned by those skilled in the art through technical manuals or conventional experimental methods.

[0038] The foregoing has shown and described the basic principles, main features, and advantages of this utility model. Those skilled in the art should understand that this utility model is not limited to the above embodiments. The embodiments and descriptions in the specification are merely illustrative of the principles of this utility model. Various changes and modifications can be made to this utility model without departing from its spirit and scope, and all such changes and modifications fall within the scope of the claims. The scope of protection of this utility model is defined by the appended claims and their equivalents.

Claims

1. A biological freeze-drying isolation system, comprising a sterile isolator body (1), an observation window (2), and an operation window (3), wherein the observation window (2) is installed on the chassis of the sterile isolator body (1), and the operation window (3) is provided on the surface of the observation window (2), characterized in that: It also includes an inner sealing mechanism (4), which includes an operating tube (5), a ring disc (6), a U-shaped connecting plate (7), an arc connecting plate (8), a U-shaped baffle (10), a U-shaped wrapping strip (11), a limiting seat (12), and a support bolt (14). The operating tube (5) is inserted into the operating window (3), and the ring disc (6) is fixed at the outer opening of the operating tube (5). The disc body of the ring disc (6) is bonded and fixed to the surface of the observation window (2). The operating tube (5) passes through the tube body of the observation window (2) and is locked with the arc connecting plate (8) by bolts. The plate body of the arc connecting plate (8) is... A U-shaped connecting plate (7) is fixed on one side. A U-shaped vertical groove (9) is vertically opened on the plate body of the U-shaped connecting plate (7). The circular groove hole of the U-shaped vertical groove (9) is connected to the operating pipe (5). A pair of limiting seats (12) are symmetrically fixed at the top of the U-shaped connecting plate (7) on both sides of the U-shaped vertical groove (9). A U-shaped baffle (10) is inserted between the pair of limiting seats (12) and the U-shaped vertical groove (9). A U-shaped wrapping strip (11) is wrapped around the edge of the U-shaped baffle (10). A through-stop hole (13) for inserting the support bolt (14) is opened between the U-shaped baffle (10) and the arc connecting plate (8).

2. The biological freeze-drying isolation system according to claim 1, characterized in that: The U-shaped vertical groove (9) has a circular cavity opening on both sides of the U-shaped connecting plate (7), and the diameter of the circular cavity of the U-shaped connecting plate (7) is the same as the diameter of the cavity of the operating pipe (5).

3. The biological freeze-drying isolation system according to claim 1, characterized in that: The inner arc plate of the arc connecting plate (8) is pressed against the upper part of the operating tube (5), and bolts are symmetrically screwed between the arc plate of the arc connecting plate (8) and the operating tube (5).

4. The biological freeze-drying isolation system according to claim 1, characterized in that: The inner wall of the U-shaped vertical groove (9) is recessed with a U-shaped inner groove, and a U-shaped wrapping strip (11) is inserted into the U-shaped inner groove of the U-shaped vertical groove (9).

5. A biological freeze-drying isolation system according to claim 1, characterized in that: The surface of the arc connecting plate (8) has a raised bump, and a through hole (13) is provided between the raised bump of the arc connecting plate (8) and the U-shaped connecting plate (7).

6. The biological freeze-drying isolation system according to claim 1, characterized in that: The length of the branch bolt (14) is greater than the depth of the cavity of the stop hole (13), and the branch bolt (14) is bonded with a glue ridge (15) on its body.

Images