High performance liquid chromatographic column filling tank

Abstract

The invention relates to the technical field of liquid chromatographic column filling tanks, in particular to a high-performance liquid chromatographic column filling tank which comprises a base plate, a mounting seat is fixedly mounted in the middle of the base plate, and a tank body is fixedly mounted on the inner side of the mounting seat. Materials can be easily added into the tank body through the feeding mechanism, after a second motor is started, a stirring auger enables a solution to roll over, the stirring and mixing efficiency is improved, meanwhile, the second motor drives a rotating shaft to rotate, an upper scraping frame and a lower scraping frame are driven to rotate, the inner wall of the tank body is evenly cleaned, adhesion of a high-viscosity solution is avoided, and during cleaning, cleaning liquid is added, and the scraping frames assist in stirring; the cleaning efficiency is improved, and after stirring is completed, an electromagnetic valve is opened to discharge materials; during cleaning, the electromagnetic valves on the side faces are opened to discharge the cleaning liquid, the cleaning liquid and the mobile phase are separated, mistaken discharge is avoided, the equipment is ingenious in design and easy and convenient to operate, the stirring, mixing and cleaning efficiency is greatly improved, and different use requirements are met.

Description

Technical Field

[0001] This application relates to the technical field of liquid chromatography column packing containers, and in particular to a high performance liquid chromatography column packing container. Background Technology

[0002] Currently, the chromatographic column is the core component in chromatographic analysis, primarily responsible for separating mixtures. In gas chromatography, the column diameter is several millimeters, filled with a solid adsorbent or liquid solvent, known as the stationary phase. Corresponding to the stationary phase is a mobile phase. The stationary phase has different affinities for the components in the sample. When the carrier gas continuously carries the sample through the column, components with higher affinities move slowly, while components with lower affinities move quickly. Qualitative and quantitative analysis results can be obtained by detecting the separated components using a detector. The high-performance liquid chromatography (HPLC) column system consists of several parts, including a reservoir, pump, injector, column, detector, and recorder. The mobile phase in the reservoir is pumped into the system by a high-pressure pump. The sample solution enters the mobile phase through the injector and is carried into the column (stationary phase). Because the components in the sample solution have different partition coefficients in the two phases, they undergo repeated adsorption and desorption processes during relative motion between the two phases. As a result, the components are separated into individual components that flow out of the column sequentially. When passing through the detector, the sample concentration is converted into an electrical signal and transmitted to the recorder. The data is then printed out in the form of a chromatogram.

[0003] Existing homogenizing tanks for packing high performance liquid chromatography columns have a high viscosity slurry that adheres to the inner wall of the tank and is not easy to drain. Most of the tanks are not easy to disassemble, and the inner wall of the tank is not easy to clean after use, which makes it inconvenient for the next use.

[0004] A search revealed Chinese patent publication number "CN218917294U" which discloses a filling device for a homogenizing tank used for filling a high-performance liquid chromatography column. The device includes a support, a tank body at the top of the support, and a feeding pipe on the right side of the tank body. A water pipe is located at the top of the tank body, and a solenoid valve is connected to the bottom of the support. The bottom of the solenoid valve is connected to the column tube. A cleaning mechanism is located on the left side of the tank body, and a stirring mechanism is located inside the tank body. After the sample solution is filled, water is injected back into the tank body. A drive motor rotates the paddle again via a rotating shaft, and a scraper dissolves any residue on the inner wall of the tank body in the water. A cylinder in the cleaning mechanism moves the plunger upward, drawing air from the piston cylinder to create a negative pressure inside, allowing waste liquid to automatically flow into the piston cylinder and then be discharged outwards. This facilitates automatic cleaning of the tank body and solves the problem of inconvenient cleaning caused by the difficult disassembly of the tank body structure in existing technologies.

[0005] Regarding the aforementioned related technologies, the inventors have discovered the following drawbacks:

[0006] While the aforementioned device possesses some cleaning capabilities, its internal cleaning structure cannot completely cover the inside of the tank during actual application. Gaps exist in the scraper's work, preventing complete coverage of the bottom, top, and sides of the tank, resulting in poor overall cleaning efficiency. Furthermore, the device utilizes a screw conveyor for loading and unloading, but the auger structure within the screw conveyor lacks a cleaning mechanism, making cleaning inconvenient. Additionally, the vertical auger is ill-suited for conveying liquid flow phases, causing the liquid to flow downwards during loading, leading to low overall loading efficiency and a tendency for liquid to overflow. Clearly, the aforementioned device has certain shortcomings and therefore requires improvement. Summary of the Invention

[0007] To improve the overall ease of operation and use of this equipment, this application provides a high-performance liquid chromatography column packing tank.

[0008] This application provides a high-performance liquid chromatography (HPLC) column packing container, which adopts the following technical solution: It includes a base plate, a mounting base fixedly installed in the middle of the base plate, a container body fixedly installed inside the mounting base, a drive mechanism fixedly installed in the middle of the rear side of the base plate, a stirring mechanism fixedly installed on the top of the drive mechanism, the bottom of the stirring mechanism extending into the interior of the container body, a feeding mechanism fixedly installed in the middle of one side of the base plate, the output end of the feeding mechanism communicating with the upper end of the container body, a discharge hopper fixedly installed at the bottom of the container body, a discharge pipe fixedly installed at the bottom of the discharge hopper, a solenoid valve fixedly installed at the bottom and one side of the discharge pipe, a chromatographic column tube fixedly installed at the bottom of the solenoid valve at the bottom of the discharge pipe, and a drain pipe fixedly installed at the outer end of the solenoid valve on one side of the discharge pipe.

[0009] Optionally, the driving mechanism includes a guide rail, which is fixedly installed in the middle of the back side of the substrate. A mounting bracket is fixedly installed on the top of the guide rail, and a driving assembly is fixedly installed on the back of the mounting bracket. A slide rod is slidably connected inside the guide rail, and the top of the slide rod is fixedly connected to the top of the stirring mechanism. The output end of the driving assembly is engaged with the slide rod.

[0010] Optionally, the drive assembly includes a first motor and a strip groove. The strip groove is formed on the back of the slide bar. The first motor is fixedly installed in the middle of one side of the mounting bracket. A transmission gear is fixedly installed through the mounting bracket at the output end of the first motor. A rack is fixedly installed inside the strip groove, and the rack and the transmission gear are meshed together.

[0011] Optionally, a support plate is fixedly installed on both sides of the bottom of the substrate, and an mounting plate is fixedly installed on the outer end of the support plate.

[0012] Optionally, mounting holes are provided at both ends of the mounting plate, and the mounting holes are countersunk holes.

[0013] Optionally, the stirring mechanism includes a fixing block, which is fixedly installed on the top of the slide rod. A top cover is fixedly installed on the bottom of the fixing block. A second motor is fixedly installed in the middle of the top of the top cover. The output end of the second motor passes through the top cover and is fixedly installed with a stirring assembly.

[0014] Optionally, the stirring assembly includes a rotating shaft, which is fixedly installed at the output end of the second motor. An upper scraper is fixedly installed at equal intervals on the outer surface of the rotating shaft, and a lower scraper is fixedly installed at equal intervals on the lower end of the outer surface of the rotating shaft. The overall cross-sectional shape of the lower scraper is an isosceles trapezoid. The outer inclined surface of the lower scraper is fitted and connected to the inner inclined surface of the discharge hopper. The outer side and top of the upper scraper are fitted and connected to the inner wall of the tank and the bottom of the top cover, respectively.

[0015] Optionally, a stirring auger is fixedly installed on the outer surface of the rotating shaft. The stirring auger is located inside the upper scraper and the lower scraper, and the lower end of the stirring auger is also set to be conical.

[0016] Optionally, the feeding mechanism includes a side rail, which is fixedly installed in the middle of one side of the base plate. A third motor is fixedly installed at the bottom of the side rail, and a lead screw is fixedly installed at the output end of the third motor. The lead screw is rotatably connected to the inside of the side rail, and a sliding plate is threadedly connected to the outer surface of the lead screw. A feeding assembly is fixedly installed at the outer end of the sliding plate.

[0017] Optionally, the feeding assembly includes a side frame and a threaded interface. The side frame is fixedly installed on the upper outer side of the slide plate. A placement seat is fixedly installed on the outer side of the side frame. A placement groove is opened in the middle of the inner side of the placement seat. A feeding cylinder is inserted into the placement groove. A regulating valve is fixedly installed at the bottom of the feeding cylinder. A hose is fixedly installed at the output end of the regulating valve. The threaded interface is fixedly installed on the upper side of the tank body. The output end of the threaded interface is connected to the inside of the tank body. The outer end of the hose is connected to the upper inside of the tank body through the threaded interface.

[0018] In summary, this application includes the following beneficial technical effects:

[0019] 1. This equipment features a stirring mechanism that facilitates material feeding. Upon starting the second motor, the auger rotates, causing the solution inside the tank to tumble and significantly improving mixing efficiency. Simultaneously, the second motor, located at the top of the cover, drives the rotating shaft, which in turn rotates the upper and lower scrapers. The upper scraper adheres to the inner wall of the tank and the bottom of the cover, while the lower scraper adheres to the bottom of the tank and the bottom of the discharge hopper, achieving uniform scraping and cleaning of any area within the tank. This effectively prevents the adhesion of high-viscosity solutions. During cleaning, simply add cleaning fluid; the upper and lower scrapers assist in stirring, improving cleaning efficiency and uniformity. After stirring, the material is discharged through the solenoid valve at the bottom of the discharge pipe. During cleaning, the cleaning fluid is discharged through the side solenoid valve, achieving separate discharge of the cleaning fluid and the mobile phase liquid to avoid accidental discharge. This equipment is ingeniously designed, easy to operate, and significantly improves mixing and cleaning efficiency, meeting diverse usage needs.

[0020] 2. By setting up a drive mechanism, this equipment can be easily cleaned and maintained after cleaning. When the first motor is started, the transmission gear rotates and meshes with the rack, driving the slide rod to slide in the guide rail. This design allows the fixed block to move upward quickly, causing the top cover to detach from the tank, thus easily pulling out the stirring mechanism. After the stirring mechanism is fully exposed, the user can easily perform deep cleaning and maintenance. This not only simplifies the cleaning process but also improves the convenience of equipment maintenance and enhances the overall operational efficiency. This equipment is ingeniously designed, highly practical, and brings great convenience to users.

[0021] 3. By setting up a feeding mechanism, this equipment achieves convenient material conveying and cleaning maintenance. Using a threaded interface to connect a hose, after the material is added to the feeding cylinder, the third motor is started to drive the lead screw to rotate, causing the slide plate to slide upwards, making the feeding cylinder higher than the threaded interface. The material then flows into the tank adaptively through the hose. During cleaning, the lead screw is driven in the opposite direction to retract the slide plate into the side rail, the hose is removed, and the feeding cylinder is taken out for cleaning. Compared with the traditional bolt-type conveyor, this design is not only more convenient for cleaning and maintenance, but also lower in cost and simpler and more efficient in operation. In addition, the feeding mechanism has a compact structure, occupies little space, and is suitable for various scenarios. This equipment improves the overall convenience and efficiency of operation by optimizing the feeding mechanism. Attached Figure Description

[0022] Figure 1 This is a schematic diagram of the overall structure in an embodiment of this application;

[0023] Figure 2 This is a schematic diagram of the feeding mechanism in the descending state in an embodiment of this application;

[0024] Figure 3 This is a schematic diagram of the feeding mechanism in the rising state in the embodiments of this application;

[0025] Figure 4This is a rear-view structural schematic diagram of an embodiment of this application;

[0026] Figure 5 This is a schematic diagram of the feeding mechanism in the embodiments of this application;

[0027] Figure 6 This is a schematic diagram of the overall structure of the stirring mechanism in the embodiments of this application;

[0028] Figure 7 This is a bottom view of the stirring mechanism in an embodiment of this application;

[0029] Figure 8 This is an embodiment of the present application. Figure 4 A magnified structural diagram at point A.

[0030] Reference numerals: 1. Base plate; 2. Mounting base; 3. Tank body; 4. Drive mechanism; 41. Guide rail; 42. Mounting bracket; 43. Drive assembly; 431. First motor; 432. Slotted groove; 433. Transmission gear; 434. Rack; 44. Slide rod; 5. Discharge hopper; 6. Feeding mechanism; 61. Side rail; 62. Third motor; 63. Lead screw; 64. Slide plate; 65. Feeding assembly; 651. Side frame; 652. Threaded interface; 65 3. Placement seat; 654. Placement trough; 655. Feeding cylinder; 656. Regulating valve; 657. Hose; 7. Stirring mechanism; 71. Fixing block; 72. Top cover; 73. Second motor; 74. Stirring assembly; 741. Rotating shaft; 742. Upper scraper; 743. Lower scraper; 744. Stirring auger; 8. Discharge pipe; 9. Solenoid valve; 10. Chromatographic column tube; 11. Drain pipe; 12. Support plate; 13. Mounting plate; 14. Mounting hole. Detailed Implementation

[0031] The following is in conjunction with the appendix Figure 1-8 This application will be described in further detail.

[0032] This application discloses a high-performance liquid chromatography column packing container. For example... Figure 1As shown, the system includes a substrate 1, a mounting base 2 fixedly mounted in the middle of the substrate 1, a tank 3 fixedly mounted inside the mounting base 2, a drive mechanism 4 fixedly mounted in the middle of the rear side of the substrate 1, a stirring mechanism 7 fixedly mounted on the top of the drive mechanism 4, the bottom of the stirring mechanism 7 extending into the interior of the tank 3, a feeding mechanism 6 fixedly mounted in the middle of one side of the substrate 1, the output end of the feeding mechanism 6 being connected to the upper end of the tank 3, a discharge hopper 5 fixedly mounted at the bottom of the tank 3, a discharge pipe 8 fixedly mounted at the bottom of the discharge hopper 5, a solenoid valve 9 fixedly mounted at the bottom and one side of the discharge pipe 8, and a chromatographic column tube 10 fixedly mounted at the bottom of the solenoid valve 9 at the bottom of the discharge pipe 8. A drain pipe 11 is fixedly installed on the outer end of the solenoid valve 9 on one side of the discharge pipe 8. The base plate 1 serves as the supporting structure for the entire equipment, stably supporting other components. The mounting base 2 is responsible for fixing the tank 3, ensuring its stability during operation. The drive mechanism 4 is located in the middle of the rear side of the base plate 1. The drive mechanism 4 can control the stirring mechanism 7, precisely controlling its lifting and lowering, allowing it to easily enter or exit the tank 3 for material stirring and cleaning. The stirring mechanism 7 is the core part of the filling tank, with its bottom extending into the tank 3. Driven by the drive mechanism 4, the stirring mechanism 7 can... The stirring mechanism 7 is designed to perform efficient stirring within the tank 3, promoting uniform mixing of materials. It also prioritizes ease of cleaning, allowing for convenient cleaning of the tank 3's interior and preventing residue from affecting subsequent experiments. The feeding mechanism 6 is located in the middle of one side of the substrate 1, with its output end connected to the upper part of the tank 3. The feeding mechanism 6 allows for convenient and rapid addition of materials to the tank 3, reducing the complexity of manual operation and improving work efficiency. The bottom of the tank 3 is equipped with a discharge hopper 5 and a discharge pipe 8, with a solenoid valve 9 installed on the discharge pipe 8. When it is necessary to discharge materials from the tank 3, the valve can be controlled... The solenoid valve 9 is switched on and off. The bottom of the solenoid valve 9 at the bottom of the discharge pipe 8 is connected to the column tube 10, which allows the stirred material to be directly delivered to the column for analysis. At the same time, the outer end of the solenoid valve 9 on one side of the discharge pipe 8 is connected to the drain pipe 11 for discharging the cleaning solution or other liquids, realizing the separation of the cleaning solution and the mobile phase and avoiding accidental discharge. This high-performance liquid chromatography column packing tank design fully considers the needs of multiple stages such as stirring, mixing, feeding, discharging and cleaning. Through the coordinated work of various components, efficient and convenient experimental operation is achieved. This equipment has broad prospects for application in the fields of chemistry and biology.

[0033] Please refer to Figure 3The drive mechanism 4 includes a guide rail 41, which is fixedly mounted on the back center of the substrate 1. A mounting bracket 42 is fixedly mounted on the top of the guide rail 41, and a drive assembly 43 is fixedly mounted on the back of the mounting bracket 42. A slide rod 44 is slidably connected inside the guide rail 41, and the top of the slide rod 44 is fixedly connected to the top of the stirring mechanism 7. The output end of the drive assembly 43 is engaged with the slide rod 44. The guide rail 41 is fixedly mounted on the back center of the substrate 1, providing a stable and precise sliding path for the slide rod 44. The mounting bracket 42 is firmly fixed to the top of the guide rail 41 to support and fix the drive assembly 43. The drive assembly 43 is mounted on the back of the mounting bracket 42, and its output end is engaged with the slide rod 44. By operating the drive assembly 43, the slide rod 44 can be driven, thereby controlling the lifting and lowering of the stirring mechanism 7. The slide rod 44 is fixedly connected to the top of the stirring mechanism 7. When the drive assembly 43 is engaged, the slide rod 44 can be driven, thereby controlling the lifting and lowering of the stirring mechanism 7. When component 43 is in operation, slide bar 44 slides up and down along guide rail 41, driving stirring mechanism 7 to perform corresponding lifting and lowering movements. This design allows stirring mechanism 7 to easily enter the tank 3 for stirring operations and quickly exit after stirring, facilitating subsequent cleaning. In addition, the design of drive mechanism 4 also considers the convenience and stability of operation. By precisely controlling the operation of drive component 43, the lifting speed and position of stirring mechanism 7 can be precisely adjusted, ensuring efficient stirring and cleaning processes. At the same time, the sliding connection between guide rail 41 and slide bar 44 uses high-quality wear-resistant material, ensuring smooth sliding and durability. This drive mechanism 4 is reasonably designed and fully functional, capable of efficiently and stably controlling the lifting and lowering movements of stirring mechanism 7, providing strong support for the stirring and cleaning operations of high-performance liquid chromatography column packing tanks.

[0034] Please refer to Figure 3The drive assembly 43 includes a first motor 431 and a strip groove 432. The strip groove 432 is formed on the back of the slide bar 44. The first motor 431 is fixedly installed in the middle of one side of the mounting bracket 42. The output end of the first motor 431 passes through the mounting bracket 42 and is fixedly installed with a transmission gear 433. A rack 434 is fixedly installed inside the strip groove 432. The rack 434 and the transmission gear 433 are meshed and connected. The first motor 431 is fixedly installed in the middle of one side of the mounting bracket 42 and is the power source for the drive assembly 43. When the motor starts, its output end rotates, driving the connected transmission gear 433 to rotate as well. The transmission gear 433 is installed at the output end of the first motor 431, passes through the mounting bracket 42, and meshes with the rack 434. This meshing connection ensures a tight fit between the transmission gear 433 and the rack 434, allowing the motor's power to be efficiently transmitted to the rack 434. The rack 434 is fixedly installed inside the slot 432, which is open... Located on the back of the slide bar 44, the rack 434 is designed to mesh with the transmission gear 433, thereby converting the rotational motion of the motor into the linear motion of the slide bar 44. When the first motor 431 starts, the transmission gear 433 begins to rotate, and through its meshing with the rack 434, it pushes the rack 434 to move up and down within the strip groove 432. Since the rack 434 and the slide bar 44 are fixedly connected, the slide bar 44 will also slide up and down accordingly. This design not only realizes the lifting and lowering control of the stirring mechanism 7, but also ensures the smoothness and accuracy of the movement. In addition, the drive assembly 43 has the advantages of simple structure, convenient operation, and high reliability. By adjusting the speed and direction of the motor, the lifting speed and direction of the stirring mechanism 7 can be precisely controlled to meet different experimental needs. This drive assembly 43, through motor drive and gear and rack 434 transmission, realizes the precise control of the lifting and lowering motion of the stirring mechanism 7, providing a strong guarantee for the efficient operation of the high-performance liquid chromatography column packing tank.

[0035] Please refer to Figure 1Support plates 12 are fixedly installed on both sides of the bottom of the substrate 1, and mounting plates 13 are fixedly installed on the outer ends of the support plates 12. This design allows the entire device to be easily installed and fixed on the laboratory bench or other work platform. The mounting plates 13 usually have sufficient area and strength to withstand the weight of the device itself and the vibration and impact that may occur during use. In addition, mounting holes 14 are usually provided on the mounting plates 13. These mounting holes 14 can be easily bolted to the laboratory bench or other fixed structures to ensure the safe fixation of the device. The mounting holes 14 are countersunk holes, which allows the bolt heads to be recessed into the holes after installation, avoiding any impact on the appearance and use of the device. The design of the support plates 12 and mounting plates 13 provides a stable and reliable installation base for the high-performance liquid chromatography column packing tank, ensuring the stability and safety of the device during operation. At the same time, this design also makes the installation and maintenance of the device more convenient.

[0036] Please refer to Figure 2 Mounting plate 13 has mounting holes 14 at both ends. These mounting holes 14 are countersunk holes. To ensure the firmness and stability of the installation, mounting holes 14 are provided at both ends of mounting plate 13. These mounting holes 14 are specially designed as countersunk holes. The characteristic of countersunk holes is that their opening has a large diameter, while the depth of the hole gradually narrows, eventually matching the shank of the bolt or screw. This design allows the mounting plate 13 to be tightly connected to the experimental table or other fixed structures using bolts or screws during installation. At the same time, the head of the bolt or screw can be completely recessed into the hole and will not protrude from the surface of the mounting plate 13. The advantages of using countersunk holes as mounting holes 14 are obvious. First, it avoids the bolt or screw head protruding from the surface of the mounting plate 13, thus ensuring the neatness and aesthetics of the equipment appearance. Second, the countersunk hole design can reduce the friction and collision caused by the bolt or screw head contacting external objects, which helps to extend the service life of the equipment. Finally, this design can also reduce the shaking or loosening of the equipment caused by improper installation to a certain extent, improving the stability and safety of the equipment.

[0037] Please refer to Figure 6The stirring mechanism 7 includes a fixed block 71, which is fixedly installed on the top of the slide rod 44. A top cover 72 is fixedly installed on the bottom of the fixed block 71, and a second motor 73 is fixedly installed in the middle of the top of the top cover 72. The output end of the second motor 73 passes through the top cover 72 and is fixedly installed with a stirring assembly 74. The stirring mechanism 7 is a key part of the high-performance liquid chromatography column packing tank. Its main function is to stir and mix the materials in the tank 3 to ensure the uniformity of the materials and the fullness of the reaction. The stirring mechanism 7 includes key components such as the fixed block 71, the top cover 72, the second motor 73, and the stirring assembly 74. They work together to complete the stirring task. The fixed block 71, as the support structure of the stirring mechanism 7, is firmly fixedly installed on the top of the slide rod 44. This ensures the stability of the stirring mechanism 7 during the lifting process and avoids operational errors or equipment damage caused by shaking or vibration. The top cover 72 is located at the bottom of the fixed block 71. It not only plays a role in sealing and protection but also serves as the mounting base for the second motor 73. The top cover 72 is designed to fit the tank 3, ensuring no interference or friction occurs between it and the interior of the tank 3 during stirring. The second motor 73 is the power source for the entire stirring mechanism 7. It is fixedly installed at the top center of the top cover 72. When the motor starts, its output end rotates, driving the connected stirring component 74 to perform stirring. This design allows the stirring mechanism 7 to work independently, facilitating precise control of stirring speed and time. The stirring component 74 is the core part of the stirring mechanism 7, directly participating in the stirring process. Driven by the second motor 73, the stirring component 74 rotates to thoroughly stir the materials inside the tank 3. Its design considers factors such as stirring effect, stirring uniformity, and material characteristics to ensure the efficiency and reliability of the stirring process. This stirring mechanism 7 is reasonably designed and fully functional, enabling uniform stirring of materials inside the tank 3, improving reaction efficiency and the accuracy of experimental results. At the same time, it has a compact structure and is easy to operate.

[0038] Please refer to Figure 6The mixing assembly 74 includes a rotating shaft 741, which is fixedly installed at the output end of the second motor 73. Upper scrapers 742 are fixedly installed at equal intervals on the outer surface of the rotating shaft 741, and lower scrapers 743 are fixedly installed at equal intervals on the lower end of the outer surface of the rotating shaft 741. The overall cross-sectional shape of the lower scraper 743 is an isosceles trapezoid. The outer inclined surface of the lower scraper 743 is fitted and connected to the inner inclined surface of the discharge hopper 5. The outer side and top of the upper scraper 742 are fitted and connected to the inner wall of the tank 3 and the bottom of the top cover 72, respectively. As the power transmission component of the stirring assembly 74, it is fixedly installed at the output end of the second motor 73. When the motor starts, the rotating shaft 741 rotates accordingly, driving the stirring component installed on it to perform stirring operations. This design ensures efficient transmission of stirring power and provides a stable and reliable power source for stirring operations. The upper scraper 742 is fixedly installed at equal intervals on the upper part of the outer surface of the rotating shaft 741. During the stirring process, the upper scraper 742 rotates with the rotation of the rotating shaft 741, and its outer side is in close contact with the inner wall of the tank 3. The top is fitted to the bottom of the top cover 72. This design allows the upper scraper 742 to effectively scrape off the material adhering to the inner wall of the tank 3, preventing material accumulation and waste, while improving the uniformity of mixing. The lower scraper 743 is also fixedly installed at equal intervals on the lower part of the outer surface of the rotating shaft 741. Its overall cross-sectional shape is an isosceles trapezoid. This design allows the outer inclined surface of the lower scraper 743 to fit tightly against the inner inclined surface of the discharge hopper 5. During the mixing process, the lower scraper 743 rotates with the rotation of the rotating shaft 741, which not only... It can effectively scrape off the material adhering to the inner wall of the discharge hopper 5 and guide the material to flow towards the discharge port, thereby accelerating the material discharge process. The design of this stirring component 74 fully considers the uniformity of stirring and the fluidity of the material. Through the combined use of the upper scraper 742 and the lower scraper 743, it can achieve comprehensive scraping of the inner wall of the tank 3 and the inner wall of the discharge hopper 5, avoiding material residue and waste. At the same time, the rotational motion of the stirring component 74 can also promote the uniform mixing of materials in the tank 3, improve stirring efficiency and reaction effect.

[0039] Please refer to Figure 6A stirring auger 744 is fixedly mounted on the outer surface of the rotating shaft 741. The stirring auger 744 is located inside the upper scraper 742 and the lower scraper 743. The lower end of the stirring auger 744 is also conical. Its spiral design effectively pushes and mixes materials. When the rotating shaft 741 rotates, the stirring auger 744 rotates accordingly, pushing the material upwards from the bottom of the tank 3, while simultaneously creating a rotating flow within the tank 3, thus achieving uniform mixing. Notably, the lower end of the stirring auger 744 is specially designed as a cone shape. This design allows the stirring auger 744 to... When the auger 744 contacts the inner wall of the discharge hopper 5, it can guide the material to the discharge port more smoothly, reducing material residue and blockage. At the same time, the conical design can also reduce the friction between the auger 744 and the inner wall of the discharge hopper 5 to a certain extent, improving the durability and service life of the equipment. The addition of the auger 744 and its conical design at the lower end not only enhances the stirring effect of the stirring mechanism 7 and improves the mixing uniformity of the material, but also optimizes the flow path of the material, reducing material residue and waste. This design makes the high-performance liquid chromatography column packing tank more efficient and reliable in stirring and mixing, providing a strong guarantee for the smooth progress of experiments and production.

[0040] Please refer to Figure 5 The feeding mechanism 6 includes a side rail 61, which is fixedly installed in the middle of one side of the base plate 1. A third motor 62 is fixedly installed at the bottom of the side rail 61, and a lead screw 63 is fixedly installed at the output end of the third motor 62. The lead screw 63 is rotatably connected to the inside of the side rail 61, and a slide plate 64 is threadedly connected to the outer surface of the lead screw 63. A feeding assembly 65 is fixedly installed at the outer end of the slide plate 64. The side rail 61, as a support and guide component of the feeding mechanism 6, is fixedly installed in the middle of one side of the base plate 1. It ensures the stability and accuracy of the slide plate 64 during movement and avoids wobbling or deviation. In case of feeding error, the third motor 62, which serves as the power source for the feeding mechanism 6, is installed at the bottom of the side rail 61. When the motor starts, its output drives the lead screw 63 to rotate. The lead screw 63 is rotatably connected to the inside of the side rail 61, converting the rotational motion of the motor into the linear motion of the slide plate 64. The slide plate 64 is connected to the outer surface of the lead screw 63 by a thread. When the lead screw 63 rotates, the slide plate 64 will move linearly along the direction of the lead screw 63. This design allows the slide plate 64 to move precisely to the designated position under the drive of the motor, thereby achieving precise control of the feeding component 65.

[0041] Please refer to Figure 6The feeding assembly 65 includes a side frame 651 and a threaded interface 652. The side frame 651 is fixedly installed on the upper outer side of the slide plate 64. A placement seat 653 is fixedly installed on the outer side of the side frame 651. A placement groove 654 is opened in the middle of the inner side of the placement seat 653. A feeding cylinder 655 is inserted into the placement groove 654. A regulating valve 656 is fixedly installed at the bottom of the feeding cylinder 655. A hose 657 is fixedly installed at the output end of the regulating valve 656. The threaded interface 652 is fixedly installed on the upper side of the tank body 3. The output end of the threaded interface 652 is connected to the inside of the tank body 3. The outer end of the hose 657 is connected to the upper inside of the tank body 3 through the threaded interface 652. The side frame 651, serving as the support structure for the feeding assembly 65, is fixedly installed on the upper outer side of the slide plate 64. It not only provides a stable mounting base for the placement seat 653 but also ensures the stability of the feeding assembly 65 during movement. The placement seat 653 is fixedly installed on the outer side of the side frame 651, and its inner center has a placement groove 654 for placing the feeding cylinder 655. This design allows the feeding cylinder 655 to be easily inserted and removed, facilitating replacement and cleaning. The feeding cylinder 655, as a component for storing and conveying materials, has a regulating valve 656 fixedly installed at its bottom. By adjusting the opening and closing degree of the regulating valve 656, the material conveying speed and flow rate can be controlled. To achieve precise control of the feeding process, a flexible hose 657 is fixedly installed at the output end of the regulating valve 656. The hose 657 has a certain degree of flexibility, allowing it to be easily bent and stretched to adapt to different installation positions and angles. The other end of the hose 657 is connected to the inside of the tank 3 via a threaded interface 652, ensuring that the material can smoothly enter the tank 3. The threaded interface 652 is fixedly installed on the upper side of the tank 3, and its design takes into account the tightness and sealing of the connection. Through the threaded connection, a reliable connection is formed between the hose 657 and the tank 3, avoiding leakage and waste of materials during the conveying process. During operation, the user only needs to... The material cylinder 655 is placed in the placement slot 654 of the placement seat 653. The material conveying speed and flow rate are controlled by the regulating valve 656. Then, the feeding mechanism 6 is started, and the slide plate 64 drives the feeding assembly 65 to move to the appropriate position. At this time, the hose 657 is connected to the inside of the tank 3 through the threaded interface 652. The material enters the inside of the tank 3 through the hose 657 under the action of gravity or pressure. This feeding assembly 65 is reasonably designed and easy to operate, and can realize the efficient and accurate delivery of materials, providing a strong guarantee for the efficient operation of the high-performance liquid chromatography column packing tank. At the same time, its compact structure and easy cleaning and maintenance improve the practicality and durability of the equipment.

[0042] The implementation principle of a high-performance liquid chromatography (HPLC) column packing tank according to this application embodiment is as follows: This device, by incorporating a stirring mechanism 7, allows materials to be added into the tank body 3 via a feeding mechanism 6 during use. At this time, the second motor 73 is activated, driving the stirring auger 744 to rotate. This auger 744 causes the solution inside the tank body 3 to tumble, resulting in higher overall mixing efficiency and improved material mixing efficiency. Simultaneously, the second motor 73, located at the top of the top cover 72, drives the rotating shaft 741 to rotate. The rotation of the shaft 741 drives the upper scraper 742 and the lower scraper 743 to rotate. The upper scraper 742 is attached to the inside of the tank body 3 and the bottom of the top cover 72, while the lower scraper 743 is attached to the bottom of the tank body 3. The bottom of the tank 3 and the bottom of the discharge hopper 5 are driven by the rotating shaft 741 to rotate the upper scraper 742 and the lower scraper 743. The upper scraper 742 and the lower scraper 743 can evenly scrape and clean any position inside the tank 3, which can prevent high viscosity solutions from adhering to the inside of the tank 3. During this cleaning process, the cleaning solution is simply added to the inside of the tank 3. The upper scraper 742 and the lower scraper 743 assist in stirring and mixing, which can improve the cleaning efficiency and uniformity inside the tank 3 of this equipment. After the material is stirred and mixed, the solenoid valve 9 located at the bottom of the discharge pipe 8 can be opened to discharge the material. When it is necessary to discharge the cleaning solution during the cleaning process, the solenoid valve 9 on the displacement side can be opened to discharge the cleaning solution. The cleaning solution and the mobile phase liquid are discharged separately, which can prevent the material from being discharged into the mobile phase when cleaning is required, and facilitate the quick discharge of the mobile phase liquid or the quick discharge of the cleaning solution.

[0043] By setting the drive mechanism 4, after the device is cleaned, the first motor 431 can be started during use. The first motor 431 drives the transmission gear 433 to rotate. The transmission gear 433 and the rack 434 mesh and connect. At this time, the drive gear abuts against the rack 434, which causes the slide rod 44 to slide inside the guide rail 41. This helps to adjust the vertical displacement of the slide rod 44, allowing the device to quickly pull the fixed block 71 upward, causing the fixed block 71 to drive the top cover 72 out of the tank 3. This allows the stirring mechanism 7 to be quickly pulled out of the tank 3. At this time, the stirring mechanism 7 is pulled out, the tank 3 is opened, and the stirring mechanism 7 is exposed to the outside. This makes it easy to clean and maintain the entire device. On the basis of easy cleaning, it further improves the convenience of further cleaning and maintenance of the entire device, and improves the overall ease of operation and use of the device.

[0044] By setting up the feeding mechanism 6, during the operation of this equipment, the hose 657 is first connected to the threaded interface 652, which connects the hose 657 to the upper end of the tank 3. Then, material is added into the feeding cylinder 655. At this time, the third motor 62 is started, which drives the lead screw 63 to rotate. The lead screw 63 rotates inside the side rail 61, which drives the slide plate 64 inside the side rail 61 to slide up and down. When the slide plate 64 moves upward, it raises the height of the feeding cylinder 655 above the threaded interface 652, and the material inside the feeding cylinder 655 can then be fed through the threaded interface 652. The hose 657 and threaded interface 652 adaptively convey the flow into the tank 3. When cleaning and maintenance are required, simply reverse the drive screw 63 of the third motor 62 to retract the slide plate 64 into the side rail 61. At this time, loosen the threaded interface 652 to remove the hose 657. Then, remove the feeding cylinder 655 placed in the placement slot 654 for disassembly and reassembly. This facilitates cleaning and maintenance of the feeding cylinder 655 and hose 657. Compared with the bolt-type conveying design in the prior art, this device is more convenient for overall cleaning and maintenance, has lower overall application costs, and is simple to operate and highly efficient.

[0045] The above are all preferred embodiments of this application, and are not intended to limit the scope of protection of this application. Therefore, all equivalent changes made in accordance with the structure, shape and principle of this application should be covered within the scope of protection of this application.

Claims

1. A high-performance liquid chromatography column packing container, characterized in that, The system includes a substrate (1), a mounting base (2) fixedly mounted in the middle of the substrate (1), a tank (3) fixedly mounted on the inner side of the mounting base (2), a drive mechanism (4) fixedly mounted in the middle of the rear side of the substrate (1), a stirring mechanism (7) fixedly mounted on the top of the drive mechanism (4), the bottom of the stirring mechanism (7) extending into the interior of the tank (3), a feeding mechanism (6) fixedly mounted in the middle of one side of the substrate (1), the output end of the feeding mechanism (6) being connected to the upper end of the tank (3), a discharge hopper (5) fixedly mounted at the bottom of the tank (3), a discharge pipe (8) fixedly mounted at the bottom of the discharge hopper (5), a solenoid valve (9) fixedly mounted on the bottom and one side of the discharge pipe (8), a chromatographic column tube (10) fixedly mounted at the bottom of the solenoid valve (9) at the bottom of the discharge pipe (8), and a drain pipe (11) fixedly mounted on the outer end of the solenoid valve (9) on one side of the discharge pipe (8).

2. The high-performance liquid chromatography column packing container according to claim 1, characterized in that, The driving mechanism (4) includes a guide rail (41), which is fixedly installed in the middle of the back side of the substrate (1). A mounting bracket (42) is fixedly installed on the top of the guide rail (41), and a driving assembly (43) is fixedly installed on the back side of the mounting bracket (42). A slide rod (44) is slidably connected inside the guide rail (41). The top of the slide rod (44) is fixedly connected to the top of the stirring mechanism (7). The output end of the driving assembly (43) is engaged with the slide rod (44).

3. A high-performance liquid chromatography column packing container according to claim 2, characterized in that, The drive assembly (43) includes a first motor (431) and a strip groove (432). The strip groove (432) is opened on the back of the slide bar (44). The first motor (431) is fixedly installed in the middle of one side of the mounting bracket (42). The output end of the first motor (431) passes through the mounting bracket (42) and is fixedly installed with a transmission gear (433). A rack (434) is fixedly installed inside the strip groove (432). The rack (434) and the transmission gear (433) are meshed and connected.

4. A high-performance liquid chromatography column packing container according to claim 1, characterized in that, Support plates (12) are fixedly installed on both sides of the bottom of the substrate (1), and mounting plates (13) are fixedly installed on the outer ends of the support plates (12).

5. A high-performance liquid chromatography column packing container according to claim 4, characterized in that, The mounting plate (13) has mounting holes (14) at both ends, and the mounting holes (14) are countersunk holes.

6. A high-performance liquid chromatography column packing container according to claim 1, characterized in that, The stirring mechanism (7) includes a fixing block (71), which is fixedly installed on the top of the slide rod (44). A top cover (72) is fixedly installed on the bottom of the fixing block (71). A second motor (73) is fixedly installed in the middle of the top of the top cover (72). The output end of the second motor (73) passes through the top cover (72) and is fixedly installed with a stirring assembly (74).

7. A high-performance liquid chromatography column packing container according to claim 6, characterized in that, The stirring assembly (74) includes a rotating shaft (741), which is fixedly installed at the output end of the second motor (73). An upper scraper (742) is fixedly installed at equal intervals on the outer surface of the rotating shaft (741), and a lower scraper (743) is fixedly installed at equal intervals on the lower end of the outer surface of the rotating shaft (741). The overall cross-sectional shape of the lower scraper (743) is an isosceles trapezoid. The outer inclined surface of the lower scraper (743) is fitted and connected to the inner inclined surface of the discharge hopper (5). The outer side and top of the upper scraper (742) are fitted and connected to the inner wall of the tank (3) and the bottom of the top cover (72), respectively.

8. A high-performance liquid chromatography column packing container according to claim 7, characterized in that, A stirring auger (744) is fixedly installed on the outer surface of the rotating shaft (741). The stirring auger (744) is located inside the upper scraper (742) and the lower scraper (743). The lower end of the stirring auger (744) is also set as a cone shape.

9. A high-performance liquid chromatography column packing container according to claim 1, characterized in that, The feeding mechanism (6) includes a side rail (61), which is fixedly installed in the middle of one side of the base plate (1). A third motor (62) is fixedly installed at the bottom of the side rail (61). A lead screw (63) is fixedly installed at the output end of the third motor (62). The lead screw (63) is rotatably connected to the inside of the side rail (61). A sliding plate (64) is threadedly connected to the outer surface of the lead screw (63). A feeding assembly (65) is fixedly installed at the outer end of the sliding plate (64).

10. A high-performance liquid chromatography column packing container according to claim 9, characterized in that, The feeding assembly (65) includes a side frame (651) and a threaded interface (652). The side frame (651) is fixedly installed on the upper outer side of the slide plate (64). A placement seat (653) is fixedly installed on the outer side of the side frame (651). A placement groove (654) is opened in the middle of the inner side of the placement seat (653). A feeding cylinder (655) is inserted into the placement groove (654). A regulating valve (656) is fixedly installed at the bottom of the feeding cylinder (655). A hose (657) is fixedly installed at the output end of the regulating valve (656). The threaded interface (652) is fixedly installed on the upper side of the tank (3). The output end of the threaded interface (652) is connected to the inside of the tank (3). The outer end of the hose (657) is connected to the upper inner end of the tank (3) through the threaded interface (652).

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