Wood vinegar traditional Chinese medicine composition for treating infertility as well as preparation method and application of wood vinegar traditional Chinese medicine composition

Abstract

The invention relates to the technical field of traditional Chinese medicines, in particular to a wood vinegar traditional Chinese medicine composition for treating infertility and a preparation method and application thereof. The pyroligneous liquor traditional Chinese medicine composition is prepared from the following components: a channel warming decoction concentrated extract, a folium artemisiae argyi-fennel co-extract, a caulis spatholobi and radix salviae miltiorrhizae water extract, zedoary turmeric oil and refined pyroligneous liquor. The meridian-warming decoction extract in the wood vinegar traditional Chinese medicine composition provided by the invention has the effects of warming meridians, dispelling cold, nourishing blood and regulating menstruation; the folium artemisiae argyi-fennel co-extract is used for warming uterus, relieving pain and improving uterus blood flow; caulis Spatholobi and Salvia miltiorrhiza aqueous extract can activate collaterals, promote blood circulation and resist The zedoary turmeric oil breaks blood, eliminates diseases and promotes intima repair; the refined wood vinegar promotes permeation and adjusts the pH value, and the cold stasis type female infertility is treated through the combined action. The pyroligneous liquor traditional Chinese medicine composition provided by the invention can be used for effectively treating the cold stasis type female infertility.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of traditional Chinese medicine, in particular to a wood vinegar traditional Chinese medicine composition for treating infertility and a preparation method and application thereof. BACKGROUND

[0002] The medical definition of infertility is that there is no successful pregnancy for 1-2 years without taking any contraceptive measures and normal sexual life. According to this strict definition, infertility is a common problem, which affects at least 10-15% of couples of childbearing age. Infertility of cold stasis type can be clinically manifested as menstrual abnormalities, menstrual period: postmenstrual period (cycle delay > 7 days), little amount of menstruation, dark purple color; menstrual quality: many blood clots (clot pain is reduced), blood is as thick as asphalt; dysmenorrhea: cold pain in the small abdomen, which is relieved by heat, and pain usually starts 1 week before menstruation. Local signs are small abdominal palpation: cold small abdomen, hard knot or cord feeling (indicating stasis) upon pressing; tongue appearance: purple tongue or ecchymosis, tortuous sublingual collaterals; pulse: tight or stringy pulse (typical pulse of cold and blood stasis) and the like. The existing commonly used traditional Chinese medicine or western medicine has unsatisfactory treatment effect. Therefore, it is necessary to provide a traditional Chinese medicine composition for treating infertility of cold stasis type. SUMMARY

[0003] In order to solve the above problems, the present application provides a wood vinegar traditional Chinese medicine composition for treating infertility and a preparation method and application thereof. The wood vinegar traditional Chinese medicine composition provided by the present application can effectively treat female infertility caused by cold stasis type.

[0004] In order to achieve the above purpose, the present application provides the following technical scheme:

[0005] The present application provides a wood vinegar traditional Chinese medicine composition for treating infertility, which comprises the following components in parts by weight: concentrated extract of Wanjing decoction 50-60 parts, co-extract of folium artemisiae argyi and cumin 10-15 parts, water extract of combined morindae officinalis and salvia miltiorrhiza 10-15 parts, zedoary oil 5-8 parts and refined wood vinegar 15-20 parts.

[0006] Preferably, the composition comprises the following components in parts by weight: concentrated extract of Wanjing decoction 55 parts, co-extract of folium artemisiae argyi and cumin 12 parts, water extract of combined morindae officinalis and salvia miltiorrhiza 12 parts, zedoary oil 7 parts and refined wood vinegar 18 parts.

[0007] Preferably, the preparation method of the concentrated extract of Wanjing decoction comprises the following steps:

[0008] 1) mixing medical gelatin, paeonia, cinnamomum, cortex moutan, evodia, syzygium aromaticum, ligusticum wallichii, angelica sinensis, prepared pinellia, ginger and licorice to obtain a mixture;

[0009] The mass ratio of the medicinal donkey-hide gelatin, paeonia, cassia twig, cortex moutan, evodia, clove, chuanxiong, angelica, prepared pinellia, ginger and licorice is 15:15:10:10:10:10:10:10:10:6:5;

[0010] 2) After mixing the mixture with water, decocting for 40-50 min, filtering, and concentrating the obtained filtrate to a density of 1.4-1.5 g / ml, a concentrated extract of Wending decoction is obtained;

[0011] The mass ratio of the mixture to water is 1:10.

[0012] Preferably, the preparation method of the Artemisia argyi-Foeniculum vulgare co-extract in step 1) comprises the following steps: supercritical carbon dioxide extraction is adopted, the temperature is 55-65 ℃, the pressure is 20-25 MPa, CO2 circulation extraction is carried out for 1.5-2.5 h, and the extract is concentrated to a density of 1.4-1.8 g / ml to obtain the Artemisia argyi-Foeniculum vulgare co-extract.

[0013] Preferably, the preparation method of the Morinda officinalis combined with Salvia miltiorrhiza water extract in step 1) comprises the following steps: Morinda officinalis, Salvia miltiorrhiza and water are mixed and decocted, and the obtained filtrate is the Morinda officinalis combined with Salvia miltiorrhiza water extract.

[0014] The mass ratio of Morinda officinalis, Salvia miltiorrhiza and water is 1-2:5-7:60-90.

[0015] Preferably, the preparation method of the refined pyroligneous liquid in step 1) comprises the following steps:

[0016] The rice straw is pyrolyzed, and the gas generated by pyrolysis is condensed to obtain a crude pyroligneous liquid; the pyrolysis conditions comprise: the temperature is 400-500 ℃, the heating rate is 5-8 ℃ / min, and the holding time is 2-3 h;

[0017] The obtained crude pyroligneous liquid is placed for more than 1 month, and the upper liquid is the refined pyroligneous liquid.

[0018] The application further provides a preparation method of the pyroligneous liquid traditional Chinese medicine composition.

[0019] The application further provides an application of the pyroligneous liquid traditional Chinese medicine composition in the preparation of a medicine for treating infertility.

[0020] The application further provides a patch for treating infertility, which comprises a base layer, a medicine coated on the base layer and an anti-sticking layer.

[0021] The base layer is pure cotton cloth, and the anti-sticking layer is silicone oil paper.

[0022] The medicine is the wood vinegar traditional Chinese medicine composition and the matrix in the above technical solution, and the mass ratio of the wood vinegar traditional Chinese medicine composition and the matrix is 3:7; the thickness of the medicine is 2-3 mm.

[0023] The matrix is rosin, beeswax and vegetable oil, and the mass ratio of the rosin, beeswax and vegetable oil is 3:1:1.

[0024] The application further provides a suppository for treating infertility, which comprises the following components in parts by weight: the wood vinegar traditional Chinese medicine composition in the above technical solution 30 parts, cocoa butter 45 parts, PEG6000 20 parts and glycerol gelatin 5 parts.

[0025] The application has the following beneficial effects:

[0026] The wood vinegar traditional Chinese medicine composition provided by the application has the following effects: the concentrated extract of Wenjing Decoction can warm the meridians and dispel cold, nourish blood and regulate menstruation; the co-extract of folium artemisiae argyi and cumin can warm the uterus and relieve pain and improve uterine blood flow; the water extract of combined morindae officinalis and salvia miltiorrhiza can activate the meridians and blood, and resist fibrosis; the zedoary oil can break blood and remove stasis, and promote endometrial repair; and the refined wood vinegar can promote penetration and regulate pH. DETAILED DESCRIPTION

[0027] The application provides a wood vinegar traditional Chinese medicine composition for treating infertility, which comprises the following components in parts by weight: concentrated extract of Wenjing Decoction 50-60 parts, co-extract of folium artemisiae argyi and cumin 10-15 parts, water extract of combined morindae officinalis and salvia miltiorrhiza 10-15 parts, zedoary oil 5-8 parts and refined wood vinegar 15-20 parts. In the application, the wood vinegar traditional Chinese medicine composition preferably comprises the following components in parts by weight: concentrated extract of Wenjing Decoction 55 parts, co-extract of folium artemisiae argyi and cumin 12 parts, water extract of combined morindae officinalis and salvia miltiorrhiza 12 parts, zedoary oil 7 parts and refined wood vinegar 18 parts. In the application, the concentrated extract of Wenjing Decoction can warm the meridians and dispel cold, nourish blood and regulate menstruation. In the application, the co-extract of folium artemisiae argyi and cumin can warm the uterus and relieve pain and improve uterine blood flow. In the application, the water extract of combined morindae officinalis and salvia miltiorrhiza can activate the meridians and blood, and resist fibrosis. In the application, the zedoary oil can break blood and remove stasis, and promote endometrial repair. In the application, the refined wood vinegar can promote penetration and regulate pH (4.0-5.0).

[0028] In the application, the preparation method of the concentrated extract of Wenjing Decoction preferably comprises the following steps:

[0029] 1) mixing medicinal gelatin, paeony, cassia twig, peony root, evodia, clove, chuanxiong, angelica, prepared pinellia, ginger and licorice to obtain a mixture; the mass ratio of the medicinal gelatin, paeony, cassia twig, peony root, evodia, clove, chuanxiong, angelica, prepared pinellia, ginger and licorice is 15:15:10:10:10:10:10:10:10:6:5; 2) mixing the mixture in step 1) with water and then decocting for 40-50 min, filtering, and concentrating the obtained filtrate to a density of 1.4-1.5 g / ml (at room temperature 25 DEG C) to obtain a concentrated extract of Wenjing decoction; the mass ratio of the mixture to water is 1:10.

[0030] In the present application, the preparation method of the Artemisia argyi-Foeniculum vulgare co-extract preferably comprises the following steps: using supercritical carbon dioxide extraction, the temperature is 55-65 DEG C, the pressure is 20-25 MPa, CO2 circulation extraction is carried out for 1.5-2.5 h, and the extract is concentrated to a density of 1.4-1.8 g / ml (at room temperature 25 DEG C) to obtain the Artemisia argyi-Foeniculum vulgare co-extract.

[0031] In the present application, the preparation method of the Spatholobi caulis and Salvia miltiorrhiza water extract preferably comprises the following steps: mixing Spatholobi caulis, Salvia miltiorrhiza and water, decocting, and filtering to obtain the Spatholobi caulis and Salvia miltiorrhiza water extract; the mass ratio of the Spatholobi caulis, Salvia miltiorrhiza and water is 1-2:5-7:60-90.

[0032] In the present application, the preparation method of the refined pyroligneous liquid comprises the following steps: pyrolyzing water rice straw, and condensing the gas produced by pyrolysis to obtain a crude pyroligneous liquid; the pyrolysis conditions comprise: the temperature is 400-500 DEG C, the heating rate is 5-8 DEG C / min, and the holding time is 2-3 h; the obtained crude pyroligneous liquid is left to stand for more than 1 month, and the upper liquid is the refined pyroligneous liquid.

[0033] The present application also provides a preparation method of the pyroligneous liquid traditional Chinese medicine composition described in the above technical solution, which comprises mixing the concentrated extract of Wenjing decoction, the Artemisia argyi-Foeniculum vulgare co-extract, the Spatholobi caulis and Salvia miltiorrhiza water extract, turmeric oil and the refined pyroligneous liquid to obtain the pyroligneous liquid traditional Chinese medicine composition.

[0034] The present application also provides the use of the pyroligneous liquid traditional Chinese medicine composition described in the above technical solution in the preparation of a medicine for treating infertility.

[0035] The application further provides a patch for treating infertility, comprising a base layer, a drug coated on the base layer, and an anti-sticking layer; the base layer is pure cotton cloth, and the anti-sticking layer is silicone oil paper; the drug is the traditional Chinese medicine composition in vinegar of deal wood and a base, the mass ratio of the traditional Chinese medicine composition in vinegar of deal wood and the base is 3:7; the thickness of the drug is 2-3 mm; the base is rosin, beeswax and vegetable oil, and the mass ratio of the rosin, the beeswax and the vegetable oil is 3:1:1. The application is not limited to the preparation method of the patch, and the conventional method can be used, for example, the base is melted, mixed with the traditional Chinese medicine composition in vinegar of deal wood, stirred at 120 DEG C for 30 min, quickly coated on the base layer, and then covered with the anti-sticking layer. In the application, the size of the patch is 8*10 cm. In the application, the use method of the patch is preferably that the patch is attached to Shenjue acupoint once a day. The infrared thermal imaging shows that the local temperature is above 12.5 DEG C after 30 min of patching.

[0036] The application further provides a suppository for treating infertility, comprising the following components in parts by weight: the traditional Chinese medicine composition in vinegar of deal wood 30 parts, cocoa butter 45 parts, PEG6000 20 parts and glycerol gelatin 5 parts. The application is not limited to the preparation method of the suppository, and the conventional method can be used, for example, the cocoa butter and PEG6000 are melted in water bath at 40 DEG C, then mixed with the traditional Chinese medicine composition in vinegar of deal wood, glycerol gelatin and homogenized, and injection molded into a suppository, each suppository weighing 3.5 g and containing 1.2 g of the drug. In the application, the use method of the suppository is preferably that one suppository is used every night after cleaning the vagina, once a day, the suppository is released in the cervix, and the drug concentration in the uterus is 8 times of the blood drug concentration (HPLC detection).

[0037] In the application, the infertility is preferably cold and stasis type infertility.

[0038] In order to further illustrate the application, the application is described in detail below in combination with examples, but they should not be understood as limiting the protection scope of the application.

[0039] Example 1

[0040] A traditional Chinese medicine composition in vinegar of deal wood for treating infertility, comprising the following components in parts by weight: concentrated extract of Wening decoction 55 parts, co-extract of folium artemisiae argyi and cumin 12 parts, co-water extract of Caulis Spatholobi and Salvia miltiorrhiza 12 parts, zedoary oil 7 parts and refined vinegar of deal wood 18 parts.

[0041] The preparation method of the concentrated extract of Wening decoction is the following steps:

[0042] 1) Mix medical donkey-hide gelatin, peony root, cinnamon twig, peony bark, evodia fruit, clove, chuanxiong rhizome, angelica root, prepared pinellia tuber, fresh ginger, and raw licorice root to obtain a mixture; the mass ratio of medical donkey-hide gelatin, peony root, cinnamon twig, peony bark, evodia fruit, clove, chuanxiong rhizome, angelica root, prepared pinellia tuber, fresh ginger, and raw licorice root is 15:15:10:10:10:10:10:10:10:6:5;

[0043] 2) After mixing the mixture from step 1) with water, boil for 40 minutes, filter, and concentrate the filtrate to a density of 1.5 g / ml to obtain the concentrated extract of Wenjing Decoction; the mass ratio of the mixture to water is 1:10.

[0044] The preparation method of the Artemisia argyi-fennel co-extract is as follows: supercritical carbon dioxide extraction is performed at a temperature of 55℃ and a pressure of 25MPa. CO2 is circulated for 2.5h, and the extract is concentrated to a density of 1.8g / ml to obtain the Artemisia argyi-fennel co-extract.

[0045] The preparation method of the aqueous extract of chicken blood vine and salvia miltiorrhiza is as follows: chicken blood vine, salvia miltiorrhiza and water are mixed and decocted, filtered, and the filtrate is the aqueous extract of chicken blood vine and salvia miltiorrhiza; the mass ratio of chicken blood vine, salvia miltiorrhiza and water is 2:7:90.

[0046] The preparation method of refined wood vinegar is as follows:

[0047] Rice straw is pyrolyzed, and the gas produced by pyrolysis is condensed to obtain crude wood vinegar. The pyrolysis conditions include: a temperature of 500℃, a heating rate of 8℃ / min, and a holding time of 3 hours. The obtained crude wood vinegar is left to stand for 1 month, and the upper liquid is refined wood vinegar.

[0048] The preparation method of the wood vinegar traditional Chinese medicine composition is as follows: the concentrated extract of Wenjing Decoction, the co-extract of Artemisia argyi and Fennel, the water extract of Spatholobus suberectus and Salvia miltiorrhiza, Curcuma zedoaria oil and refined wood vinegar are mixed to obtain the wood vinegar traditional Chinese medicine composition.

[0049] Example 2

[0050] A traditional Chinese medicine composition for treating infertility using wood vinegar comprises the following components in parts by weight: 50 parts of concentrated extract of Wenjing Decoction, 10 parts of Artemisia argyi-Fennel co-extract, 10 parts of water extract of Spatholobus suberectus and Salvia miltiorrhiza, 5 parts of Curcuma zedoaria oil, and 20 parts of refined wood vinegar.

[0051] The rest is the same as in Example 1.

[0052] Example 3

[0053] A traditional Chinese medicine composition for treating infertility using wood vinegar comprises the following components in parts by weight: 60 parts of concentrated extract of Wenjing Decoction, 15 parts of Artemisia argyi-Fennel co-extract, 15 parts of water extract of Spatholobus suberectus and Salvia miltiorrhiza, 8 parts of Curcuma zedoaria oil, and 15 parts of refined wood vinegar.

[0054] The rest is the same as in Example 1.

[0055] Example 4

[0056] A patch for treating infertility consists of a base layer, a drug applied to the base layer, and an anti-adhesive layer;

[0057] The base layer is made of pure cotton cloth, and the anti-adhesive layer is made of silicone paper.

[0058] The drug is the wood vinegar traditional Chinese medicine composition and matrix prepared in Example 1, with a mass ratio of traditional Chinese medicine composition to matrix of 3:7; the thickness of the drug on the matrix is ​​3 mm;

[0059] The matrix consists of rosin, beeswax, and vegetable oil, with a mass ratio of 3:1:1.

[0060] The patch measures 8×10cm.

[0061] After melting the matrix, it is mixed with the wood vinegar herbal composition, stirred at 120°C for 30 minutes, quickly applied to the base layer, and then covered with an anti-sticking layer.

[0062] Example 5

[0063] The difference from Example 4 is that the wood vinegar herbal composition of Example 2 is used.

[0064] Example 6

[0065] The difference from Example 4 is that the wood vinegar herbal composition of Example 3 is used.

[0066] Example 7

[0067] A suppository for treating infertility comprises the following components in parts by weight: 30 parts of the wood vinegar herbal composition prepared in Example 1, 45 parts of cocoa butter, 20 parts of PEG6000, and 5 parts of glycerin gelatin.

[0068] Preparation method: The cocoa butter and PEG6000 are melted in a water bath at 40°C, then mixed with the wood vinegar traditional Chinese medicine composition and glycerin gelatin, homogenized, and injection molded, with each suppository weighing 3.5g.

[0069] Example 8

[0070] The difference from Example 7 is that the wood vinegar herbal composition of Example 2 is used.

[0071] Example 9

[0072] The difference from Example 7 is that the wood vinegar herbal composition of Example 3 is used.

[0073] Application examples

[0074] 1. In 2024, 300 female patients with infertility due to cold stagnation were selected as the research subjects. They were aged 25 to 40 years and were randomly divided into 6 groups with 50 patients in each group. The patches prepared in Examples 4 to 6 and the patches prepared in Examples 7 to 9 were used respectively.

[0075] Symptoms of infertility in women with cold-blood stasis type:

[0076] I. Core Clinical Manifestations

[0077] 1. Menstrual irregularities

[0078] Menstrual period: Late menstrual period (cycle delayed by more than 7 days), scanty menstrual flow, dark purple color;

[0079] Menstrual blood quality: Many blood clots (pain decreases after clots are passed), menstrual blood is thick and tarry;

[0080] Menstrual cramps: lower abdominal pain that is aggravated by pressure and relieved by warmth; pain often begins one week before menstruation.

[0081] 2. Local signs

[0082] Lower abdominal palpation: The lower abdomen is cold, and pressing it reveals nodules or cord-like sensations (suggesting blood stasis);

[0083] Tongue appearance: The tongue is dark purple or has ecchymosis, and the sublingual veins are bluish-purple and tortuous;

[0084] Pulse characteristics: The pulse is deep and tight or wiry and hesitant (a typical pulse characteristic of cold stagnation and blood stasis).

[0085] 3. Systemic symptoms

[0086] Feeling cold and having cold limbs: especially cold lower limbs, which worsens in autumn and winter;

[0087] Dull complexion: dark circles under the eyes, dry and flaky skin;

[0088] Depression: Those with qi stagnation may experience chest and rib distension and frequent sighing.

[0089] II. Pathological Features of the Reproductive System

[0090] Table 1 Pathological features of the reproductive system

[0091] Modern medical manifestations TCM pathogenesis explanation Thin endometrium / high blood flow resistance (ultrasound) Blood stasis due to cold accumulation, loss of nourishment of the uterus Tubal patency but not smooth or adhesion Blood stasis blocking the Chong and Ren channels, unsmooth collaterals Delayed follicular development (B-mode ultrasound monitoring) Deficiency of kidney yang and cold accumulation leading to follicular maturation disorder Luteal dysfunction (low progesterone) Inadequate blood reaching the uterus, insufficient warming during the luteal phase

[0092] 2. Treatment methods

[0093] The patch is to be applied to the Shenque acupoint once a day for 3 months.

[0094] The suppository is to be used as follows: use one suppository after cleaning the vagina each night, once a day, for 3 months.

[0095] Pregnancy status will be tracked within one year after the use ends.

[0096] Table 2 Treatment Effects

[0097] Group Number of cases Pregnancy Abortion Infertility Example 4 50 46 4 0 Example 5 50 44 5 1 Example 6 50 42 6 2 Example 7 50 45 4 1 Example 8 50 43 4 3 Example 9 50 42 3 5

[0098] As can be seen from Table 2, the traditional Chinese medicine composition provided by the present invention can effectively treat female infertility caused by cold stagnation.

[0099] Although the above embodiments have provided a detailed description of the present invention, they are only some embodiments of the present invention, and not all embodiments. People can obtain other embodiments based on these embodiments without creative effort, and these embodiments all fall within the protection scope of the present invention.

Claims

1. A traditional Chinese medicine composition for treating infertility using wood vinegar, characterized in that, It includes the following components in parts by weight: 50-60 parts of concentrated extract of Wenjing Decoction, 10-15 parts of Artemisia argyi-Fennel co-extract, 10-15 parts of water extract of Spatholobus suberectus and Salvia miltiorrhiza, 5-8 parts of Curcuma zedoaria oil, and 15-20 parts of refined wood vinegar.

2. The wood vinegar traditional Chinese medicine composition according to claim 1, characterized in that, The components include the following parts by weight: 55 parts of concentrated extract of Wenjing Decoction, 12 parts of Artemisia argyi-Fennel co-extract, 12 parts of water extract of Spatholobus suberectus and Salvia miltiorrhiza, 7 parts of Curcuma zedoaria oil, and 18 parts of refined wood vinegar.

3. The wood vinegar traditional Chinese medicine composition according to claim 1 or 2, characterized in that, The preparation method of the concentrated extract of Wenjing Decoction includes the following steps: 1) Mix medical donkey-hide gelatin, peony root, cinnamon twig, peony bark, evodia fruit, clove, chuanxiong rhizome, angelica root, prepared pinellia tuber, fresh ginger, and raw licorice root to obtain a mixture; The mass ratio of the medicinal donkey-hide gelatin, peony root, cinnamon twig, peony bark, evodia fruit, clove, chuanxiong rhizome, angelica root, prepared pinellia tuber, fresh ginger, and raw licorice root is 15:15:10:10:10:10:10:10:10:6:

5. 2) After mixing the mixture described in step 1) with water, decoct for 40-50 minutes, filter, and concentrate the filtrate to a density of 1.4-1.5 g / ml to obtain the concentrated extract of Wenjing Decoction. The mass ratio of the mixture to water is 1:

10.

4. The wood vinegar traditional Chinese medicine composition according to claim 1 or 2, characterized in that, Step 1) The preparation method of the Artemisia argyi-fennel co-extract includes the following steps: supercritical carbon dioxide extraction is performed at a temperature of 55-65℃ and a pressure of 20-25MPa. CO2 is circulated for 1.5-2.5 hours, and the extract is concentrated to a density of 1.4-1.8g / ml to obtain the Artemisia argyi-fennel co-extract.

5. The wood vinegar traditional Chinese medicine composition according to claim 1 or 2, characterized in that, Step 1) The preparation method of the aqueous extract of chicken blood vine and salvia miltiorrhiza includes the following steps: chicken blood vine, salvia miltiorrhiza and water are mixed and decocted, filtered, and the filtrate is the aqueous extract of chicken blood vine and salvia miltiorrhiza. The mass ratio of chicken blood vine, salvia miltiorrhiza and water is 1-2:5-7:60-90.

6. The wood vinegar traditional Chinese medicine composition according to claim 1 or 2, characterized in that, Step 1) The preparation method of the refined wood vinegar includes the following steps: Rice straw is pyrolyzed, and the gas produced by pyrolysis is condensed to obtain crude wood vinegar. The pyrolysis conditions include: a temperature of 400-500℃, a heating rate of 5-8℃ / min, and a holding time of 2-3 hours. The crude wood vinegar solution is left to stand for more than one month, and the liquid on top is the refined wood vinegar solution.

7. A method for preparing the wood vinegar traditional Chinese medicine composition according to any one of claims 1 to 6, characterized in that, The concentrated extract of Wenjing Decoction, the co-extract of Artemisia argyi and Fennel, the aqueous extract of Spatholobus suberectus and Salvia miltiorrhiza, Curcuma zedoaria oil and refined wood vinegar were mixed to obtain a wood vinegar traditional Chinese medicine composition.

8. The use of the wood vinegar traditional Chinese medicine composition according to any one of claims 1 to 6 in the preparation of a drug for treating infertility.

9. A patch for treating infertility, characterized in that, This includes the base layer, the medication applied to the base layer, and the anti-adhesion layer; The base layer is pure cotton cloth, and the anti-stick layer is silicone paper; The drug is the wood vinegar traditional Chinese medicine composition and matrix according to any one of claims 1 to 6, wherein the mass ratio of the traditional Chinese medicine composition and the matrix is ​​3:7; the thickness of the drug is 2 to 3 mm; The matrix is ​​composed of rosin, beeswax, and vegetable oil, with a mass ratio of rosin, beeswax, and vegetable oil of 3:1:

1.

10. A suppository for treating infertility, characterized in that, The components include the following parts by weight: The wood vinegar traditional Chinese medicine composition according to any one of claims 1 to 6 comprises 30 parts, cocoa butter 45 parts, PEG6000 20 parts, and glycerin gelatin 5 parts.