Application of Occludin gene in preparation of medicine for regulating porcine deltacoronavirus infection

Abstract

The invention discloses an application of an Occludin gene or an Occludin protein in preparation of a medicine for regulating and controlling porcine deltacoronavirus infection. The invention discovers that the expression level of Occludin is related to porcine deltacoronavirus infection for the first time, and overexpression of the Occludin gene can significantly promote porcine deltacoronavirus infection. The expression of the Occludin gene is knocked down by the interference of shRNA, so that the porcine delta coronavirus infection can be obviously inhibited; furthermore, the Occludin is used as a drug target, and the gridding protein and the macropinocytosis inhibitor can weaken the promotion effect of the Occludin on virus infection. The Occludin and the inhibitor thereof provided by the invention can regulate and control the infection process of the porcine deltacoronavirus, and are of great significance to research on the pathogenesis of the porcine deltacoronavirus, vaccine production and research and development of prevention and / or treatment drugs.

Images