Analysis device

Abstract

An analysis device (100) includes at least one of a chromatograph and a mass spectrometer, and is provided with sensors (16, 25, 26), a storage unit (32), and a comparison processing unit (311). The sensors (16, 25, 26) detect the state of the analysis device (100) and output sensor values corresponding to the state. The storage unit (32) stores sensor value data indicating a change over time in the sensor value accompanying the elapse of analysis time. A comparison processing unit (311) compares, with a threshold value, a difference between the sensor values at the same analysis time or a difference between values indicating changes in the sensor values within the same analysis time range, with respect to a plurality of pieces of sensor value data obtained by performing a plurality of times of analysis under the same analysis condition.

Description

TECHNICAL FIELD

[0001] The present application relates to an analysis device including at least one of a chromatograph and a mass analysis device. BACKGROUND

[0002] In a case where analysis is performed using an analysis device, depending on the state of the analysis device, it can not be possible to obtain an accurate analysis result. Therefore, an analysis device is proposed that has a function of determining whether the analysis device is in a normal state by comparing each control value in the analysis device with a reference value. In this case, the reference value is an absolute value.

[0003] In Patent Literature 1 described below, regarding a method of confirming whether the performance of an analysis device remains a reference value, a technology is proposed that easily recognizes a change in the performance of an analysis device in which the performance is slowly decreasing. Specifically, a technology is proposed that arranges and outputs index information that is an index of the performance of an analysis device in chronological order, and performs notification of a prescribed warning depending on a determination result of whether the index information exceeds a threshold value that is set in advance.

[0004] Further, in Patent Literature 2 described below, a technology is proposed that, for a space charge effect that is a phenomenon that affects mass analysis, calculates a reliability in a case where the space charge effect is corrected based on a mass spectrum, and compares the reliability with a prescribed threshold value.

[0005] PRIOR ART DOCUMENTS

[0006] PATENT LITERATURE

[0007] Patent Literature 1: Japanese Patent Application Publication No. 2020-193824

[0008] Patent Literature 2: Japanese Patent Application Publication No. 2014-59964 SUMMARY

[0009] PROBLEMS TO BE SOLVED BY THE INVENTION

[0010] However, even in a case where each parameter is compared with a threshold value composed of an absolute value and determined to be normal, cases where accurate analysis results cannot be obtained if the analysis results are confirmed are not uncommon. Therefore, in order to more reliably obtain accurate analysis results, a technology capable of more highly accurately determining the state of an analysis device is required.

[0011] The present application was made in view of the above-described actual circumstances, and aims to provide an analysis device capable of more highly accurately determining the state of an analysis device.

[0012] MEANS FOR SOLVING THE PROBLEMS

[0013] A first aspect of the present application is an analysis device including at least one of a chromatograph and a mass spectrometer, and having a sensor, a storage unit, and a comparison processing unit. The sensor detects a state of the analysis device and outputs a sensor value corresponding to the state. The storage unit stores sensor value data indicating a chronological change in the sensor value along with the passage of analysis time. The comparison processing unit compares, for a plurality of pieces of the sensor value data obtained by performing analysis a plurality of times under the same analysis conditions, a difference in the sensor value at the same analysis time or a difference in a value indicating a change in the sensor value within the same analysis time range with a threshold value.

[0014] A second aspect of the present application is an analysis device including at least one of a chromatograph and a mass spectrometer, and having a sensor, a storage unit, and a comparison processing unit. The sensor detects a state of the analysis device and outputs a sensor value corresponding to the state. The storage unit stores sensor value data indicating a chronological change in the sensor value along with the passage of analysis time. The comparison processing unit compares, for a plurality of pieces of the sensor value data obtained by performing analysis a plurality of times under the same analysis conditions, a difference in an image of each piece of the sensor value data within the same analysis time range with a threshold value.

[0015] Effects of Invention

[0016] According to the present application, the state of the analysis device can be determined with higher accuracy based on the comparison result of the comparison processing unit. BRIEF DESCRIPTION OF DRAWINGS

[0017] Figure 1 is a schematic diagram showing an embodiment of an analysis device.

[0018] Figure 2 is a block diagram showing an example of an electrical configuration of an analysis device.

[0019] Figure 3A is a graph for explaining an example of the processing of the comparison processing unit, showing sensor value data of a vacuum degree in a case where the analysis device is normal.

[0020] Figure 3B is a graph for explaining an example of the processing of the comparison processing unit, showing sensor value data of a vacuum degree in a case where the analysis device is abnormal.

[0021] Figure 4A is a graph for explaining another example of the processing of the comparison processing unit, showing sensor value data of an interface current in a case where the analysis device is normal.

[0022] Figure 4B is a graph for explaining another example of the processing of the comparison processing unit, showing sensor value data of an interface current in a case where the analysis device is abnormal.

[0023] Figure 5 is a view for explaining one example of the processing of the display processing section.

[0024] Figure 6 is a view for explaining another example of the processing of the display processing section. DETAILED DESCRIPTION

[0025] 1. Overall configuration of analysis device

[0026] Figure 1 is a schematic view showing one embodiment of an analysis device 100. The analysis device 100 is a device that combines a liquid chromatograph 1 and a mass spectrometer 2, and introduces a liquid sample into the mass spectrometer 2 via the liquid chromatograph 1.

[0027] The liquid chromatograph 1 is provided with a mobile phase storage section 11, a pump 12, a sample injection device 13, a chromatographic column 14, and a column oven 15, and the like. In the mobile phase storage section 11, for example, a mobile phase composed of a liquid such as an organic solvent is stored. The mobile phase in the mobile phase storage section 11 is sent out by driving of the pump 12, and is supplied to the chromatographic column 14. The pump 12 is, for example, a liquid sending pump composed of a high-pressure pump, and sends out the mobile phase from the mobile phase storage section 11 at a set pressure.

[0028] The mobile phase supplied to the chromatographic column 14 is injected with a liquid sample at an arbitrary timing from the sample injection device 13. By this, the liquid sample is supplied to the chromatographic column 14 together with the mobile phase. The chromatographic column 14 is housed in the column oven 15. The column oven 15 is heated by a heater (not shown), and in the process in which the liquid sample passes through the chromatographic column 14 in the column oven 15 that is heated, the components in the liquid sample are separated over time.

[0029] The liquid sample that has passed through the chromatographic column 14 is introduced into the mass spectrometer 2 in a state in which the components in the liquid sample are separated. That is, the components in the separated liquid sample are sequentially introduced from the liquid chromatograph 1 into the mass spectrometer 2.

[0030] The mass spectrometer 2 is provided with an ionization section 21, a detector 22, and the like. The components in the liquid sample introduced from the liquid chromatograph 1 into the mass spectrometer 2 are ionized in the ionization section 21, and are supplied into a vacuum chamber 24 via an interface 23. By applying a voltage to the interface 23, analysis is performed in a state in which a set current (interface current) flows through the interface 23.

[0031] In the analysis, the inside of the vacuum chamber 24 is brought to a vacuum state by reducing the pressure by a vacuum pump (not shown). In the vacuum chamber 24, in addition to the detector 22, for example, an ion lens, a quadrupole mass spectrometer, and the like (all not shown) are provided. The ions introduced into the vacuum chamber 24 from the ionization section 21 via the interface 23 are separated according to the mass-to-charge ratio, and detected by the detector 22. Thereby, a chromatogram as analysis data is obtained.

[0032] In addition, the set pressure of the pump 12, the set temperature in the column oven 15, the set current of the interface 23, or the set pressure in the vacuum chamber 24, and the like are examples of parameters of the analysis conditions, but various other parameters can be included in the analysis conditions.

[0033] 2. Electrical configuration of the analysis device

[0034] Figure 2 is a block diagram showing an example of the electrical configuration of the analysis device 100. The operation of the analysis device 100 is controlled by the control device 3. The control device 3 is provided with a control section 31, a storage section 32, a display section 33, and the like.

[0035] The control section 31 is electrically connected to the storage section 32 and the display section 33. The storage section 32 includes, for example, a ROM (Read Only Memory), a RAM (Random Access Memory), or a hard disk, and stores necessary data in addition to a computer program. The display section 33 is, for example, a configuration including a liquid crystal display.

[0036] In the storage section 32, signals (sensor values) output from various sensors provided in the liquid chromatograph 1 and the mass spectrometer 2 are stored. The sensor values are output values from sensors for detecting the state of the analysis device 100 (the liquid chromatograph 1 or the mass spectrometer 2, or the like), and are distinguished from output values (analysis data) from the detector 22 in that they are values corresponding to the state of the analysis device 100.

[0037] As the above-described sensors, the pressure gauge 16 provided in the liquid chromatograph 1, or the vacuum gauge 25 or the ammeter 26 provided in the mass spectrometer 2, or the like can be exemplified. The pressure gauge 16 detects the pump pressure (discharge pressure) of the pump 12. The vacuum gauge 25 detects the degree of vacuum based on the pressure in the vacuum chamber 24. The ammeter 26 detects the current (interface current) flowing through the interface 23.

[0038] The sensor value output from these sensors is associated with the elapsed time in the analysis (analysis time), whereby it is stored in the storage section 32 as data (sensor value data) representing the chronological change in the sensor value accompanying the passage of the analysis time. That is, in the storage section 32, the sensor value data is stored separately from the analysis data. In the case where a plurality of analyses are performed, the analysis data and the sensor value data for each analysis are stored in association with each other in the storage section 32.

[0039] The control section 31 is constituted, for example, by a processor including a CPU (Central Processing Unit). By executing a computer program by the processor, the control section 31 functions as a comparison processing section 311, a report processing section 312, a display processing section 313, and the like.

[0040] The comparison processing section 311 performs comparison processing using the sensor value data stored in the storage section 32 in order to determine the state of the analysis device 100. The specific processing of the comparison processing section 311 will be described later.

[0041] The report processing section 312 performs processing of reporting the abnormality of the analysis device 100 based on the comparison result of the comparison processing section 311. Specifically, in the case where the comparison result of the comparison processing section 311 is that the state of the analysis device 100 is determined to be abnormal, processing is performed to cause the display section 33 to display this. However, the reporting of the report processing section 312 is not limited to being performed by the display to the display section 33, and can be performed by other means such as sound, for example. Furthermore, it can be configured such that the report processing section 312 reports not only in the case where the state of the analysis device 100 is determined to be abnormal, but also in the case where it is determined to be normal.

[0042] The display processing section 313 performs display to the display section 33 based on the data stored in the storage section 32. Specifically, in addition to being able to cause the analysis data (chromatogram) stored in the storage section 32 to be displayed to the display section 33, it is also able to display an image based on the sensor value data stored in the storage section 32.

[0043] 3. Example of processing by comparison processing section

[0044] Figure 3A and Figure 3B is a graph for explaining an example of the processing by the comparison processing section 311. Figure 3A sensor value data of the vacuum degree in the case where the analysis device 100 is normal, Figure 3BThe sensor value data of the vacuum degree in the case where the analysis device 100 is abnormal is shown. This vacuum degree indicates the chronological change of the sensor value output from the vacuum gauge 25 at each analysis. The processing of the comparison processing section 311 can be performed using any one of the methods exemplified by (3-1) to (3-3) below using a plurality of sensor value data obtained by performing a plurality of analyses under the same analysis conditions.

[0045] (3-1) Processing using the difference in sensor value at the same analysis time

[0046] The difference between the sensor value at an arbitrary time T11 in the analysis under the reference state as shown in Figure 3A by the comparison processing section 311, and the sensor value at the same time T11 in the analysis of the sensor value data to be compared as shown in Figure 3B is calculated, and the difference is compared with the threshold value. That is, for a plurality of sensor value data obtained by performing a plurality of analyses under the same analysis conditions, the difference in sensor value at the same analysis time (time T11) is compared with the threshold value, whereby the processing of the comparison processing section 311 is performed.

[0047] For a plurality of sensor value data obtained by performing a plurality of analyses under the same analysis conditions, in the case where the difference in sensor value at the same analysis time (time T11) is compared with the threshold value, the "same analysis time" can be an arbitrary time in the analysis, or can be a time set in advance.

[0048] (3-2) Processing using a value indicating the change in sensor value within the same analysis time range

[0049] The difference between the value indicating the change in sensor value within an arbitrary time range T12 in the analysis under the reference state as shown in Figure 3A by the comparison processing section 311, and the value indicating the change in sensor value within the same time range T12 in the analysis of the sensor value data to be compared as shown in Figure 3B is calculated, and the difference is compared with the threshold value. That is, for a plurality of sensor value data obtained by performing a plurality of analyses under the same analysis conditions, the difference in the value indicating the change in sensor value within the same analysis time range (time range T12) is compared with the threshold value, whereby the processing of the comparison processing section 311 is performed.

[0050] In this case, the value indicating the change in sensor value can be calculated using, for example, the average value or the standard deviation of the sensor value within the time range T12, but is not limited to such a method, and can be calculated using any other arbitrary method.

[0051] For a plurality of sensor value data obtained by performing a plurality of analyses under the same analysis conditions, in a case where a difference of values indicating a change in the sensor value within the same analysis time range (time range T12) is compared with a threshold value, the "same analysis time range" can be all of the time range from the start to the end of the analysis, or can be a part of the time range. In a case where it is a part of the time range, it can be an arbitrary time range in the analysis, or can be a time range set in advance.

[0052] (3-3) Processing using an image indicating sensor value data within the same analysis time range

[0053] The normal state of the analysis device 100 as shown in Figure 3A is taken as a reference state, and the comparison processing section 311 calculates a difference of images indicating the sensor value data within an arbitrary time range T12 in the analysis in the reference state, as shown in Figure 3B , from an image of the sensor value data within the same time range T12 in the analysis which becomes a comparison target, and compares the difference with a threshold value. That is, for a plurality of sensor value data obtained by performing a plurality of analyses under the same analysis conditions, a difference of images indicating each of the sensor value data within the same analysis time range (time range T12) is compared with a threshold value, and thus the processing of the comparison processing section 311 is performed.

[0054] In this case, the difference of the images indicating each of the sensor value data can be calculated, for example, by finding a difference based on values of each of the images which are numerically converted using image recognition or machine learning or the like, but is not limited to such a method, and can be calculated using any other arbitrary method.

[0055] For a plurality of sensor value data obtained by performing a plurality of analyses under the same analysis conditions, in a case where a difference of values indicating a change in the sensor value within the same analysis time range (time range T12) is compared with a threshold value, the "same analysis time range" can be all of the time range from the start to the end of the analysis, or can be a part of the time range. In a case where it is a part of the time range, it can be an arbitrary time range in the analysis, or can be a time range set in advance.

[0056] According to the processing like (3-1) or (3-2), although the state of the analysis device 100 is abnormal, even in a case where it is determined to be normal by comparing the sensor value with the threshold value, by comparing the difference of the sensor values, or the difference of the values indicating the change of the sensor values, with the threshold value, it is possible to determine that the state of the analysis device 100 is abnormal with high precision. Further, according to the processing like (3-3), although the state of the analysis device 100 is abnormal, even in a case where it is determined to be normal by comparing the sensor value with the threshold value, by comparing the difference of the images of the sensor value data with the threshold value, it is possible to determine that the state of the analysis device 100 is abnormal with high precision.

[0057] In addition, the sensor value data in the reference state corresponding to Figure 3A may be the sensor value data at the first analysis in the plurality of analyses, can be the sensor value data at the first analysis before the analysis in which the sensor value data to be compared is obtained, or can be arbitrary sensor value data selected by the user. Further, the sensor value data in the reference state can be calculated by image recognition or machine learning based on the images of the sensor value data at the plurality of analyses.

[0058] 4. Another example of the processing of the comparison processing section

[0059] Figure 4A and Figure 4B is a view for explaining another example of the processing of the comparison processing section 311. Figure 4A sensor value data of the interface current in a case where the analysis device 100 is normal, Figure 4B sensor value data of the interface current in a case where the analysis device 100 is abnormal. The interface current indicates the chronological change of the sensor value output from the ammeter 26 at each analysis. The processing of the comparison processing section 311 can be performed by any one of the methods exemplified by (4-1) to (4-3) below using a plurality of sensor value data obtained by a plurality of analyses performed under the same analysis conditions.

[0060] (4-1) Processing using the difference of the sensor values at the same analysis time

[0061] The state of the analysis device 100 shown in Figure 4A is assumed to be the reference state, and the sensor value at an arbitrary time T21 in the analysis in the reference state is calculated by the comparison processing section 311, and the sensor value at the same time T21 in the analysis in the state shown in Figure 4BThe difference between sensor values ​​at the same time T21 in the analysis of sensor value data that are shown as comparison objects is compared with a threshold. That is, for multiple sensor value data obtained by performing multiple analyses under the same analysis conditions, the difference between sensor values ​​at the same analysis time (time T21) is compared with a threshold, thereby performing the processing of the comparison processing unit 311.

[0062] For multiple sensor value data obtained by performing multiple analyses under the same analytical conditions, when comparing the difference of sensor values ​​at the same analysis time (time T21) with a threshold, "same analysis time" can be any time during the analysis or a pre-set time.

[0063] (4-2) Processing using values ​​representing changes in sensor values ​​within the same analysis time range

[0064] Will as Figure 4A The analysis apparatus 100 shown is in its normal state as a reference state. The comparison processing unit 311 calculates the value representing the change of sensor values ​​within any time range T22 in the analysis under the reference state, and the value representing... Figure 4B The difference between the values ​​representing the changes in sensor values ​​within the same time range T22 in the analysis of the sensor value data shown as the comparison object is compared with a threshold. That is, for multiple sensor value data obtained by performing multiple analyses under the same analysis conditions, the difference between the values ​​representing the changes in sensor values ​​within the same analysis time range (time range T22) is compared with a threshold, thereby performing the processing of the comparison processing unit 311.

[0065] In this case, the value representing the change in sensor value can be calculated, for example, using the average or standard deviation of the sensor values ​​within the time range T22, but is not limited to such a method; any other method can be used to calculate it.

[0066] For multiple sensor value data obtained through multiple analyses under the same analytical conditions, when comparing the difference of the values ​​representing the changes in sensor values ​​within the same analytical time range (time range T22) with a threshold, the "same analytical time range" can be the entire time range from the beginning to the end of the analysis, or it can be a partial time range. If it is a partial time range, it can be any time range within the analysis, or it can be a pre-set time range.

[0067] (4-3) Processing of images representing sensor value data within the same analysis time range

[0068] Will as Figure 4AThe state of the analysis device 100 shown as normal is taken as a reference state, and the comparison processing section 311 calculates the difference in the image representing the sensor value data in an arbitrary time range T22 in the analysis in the reference state from the image representing the sensor value data in the same time range T22 in the analysis as Figure 4B the same time range T22 in the analysis shown as the sensor value data to be compared, and compares the difference with a threshold value. That is, for a plurality of sensor value data obtained by performing a plurality of analyses under the same analysis conditions, the difference in the image representing each of the sensor value data in the same analysis time range (time range T22) is compared with a threshold value, and thus the processing of the comparison processing section 311 is performed.

[0069] In this case, the difference in the image representing each of the sensor value data can be calculated, for example, by finding the difference in the value based on each of the images that is numerically converted using image recognition or machine learning or the like, but is not limited to such a method, and can be calculated using any other method.

[0070] For a plurality of sensor value data obtained by performing a plurality of analyses under the same analysis conditions, in the case where the difference in the image representing each of the sensor value data in the same analysis time range (time range T22) is compared with a threshold value, the "same analysis time range" can be all of the time range from the start to the end of the analysis, or can be a part of the time range. In the case of being a part of the time range, it can be an arbitrary time range in the analysis, or can be a time range set in advance.

[0071] According to the processing like (4-1) or (4-2), although the state of the analysis device 100 is abnormal, even in the case where the sensor value is determined to be normal by comparing the sensor value with a threshold value, by comparing the difference in the sensor value, or the difference in the value representing the change in the sensor value, with a threshold value, it is possible to accurately determine that the state of the analysis device 100 is abnormal. Further, according to the processing like (4-3), although the state of the analysis device 100 is abnormal, even in the case where the sensor value is determined to be normal by comparing the sensor value with a threshold value, by comparing the difference in the image representing each of the sensor value data with a threshold value, it is possible to accurately determine that the state of the analysis device 100 is abnormal.

[0072] In addition, the sensor value data in the reference state corresponding to Figure 4A may be the sensor value data at the first analysis in a plurality of analyses, can be the sensor value data at the first analysis before the analysis of the sensor value data to be compared, or can be an arbitrary sensor value data selected by the user. Further, the sensor value data in the reference state can be calculated based on image recognition or machine learning or the like of the sensor value data at a plurality of analyses.

[0073] 5. One example of the processing of the display processing section

[0074] Figure 5 is a view for explaining one example of the processing of the display processing section 313. In this example, images representing a plurality of sensor value data obtained by performing a plurality of analyses under the same analysis condition are displayed by the display processing section 313 so as to be overlaid on the display section 33. Here, "overlaid display" means display based on the same vertical and horizontal axes, and the "images" representing the sensor value data are charts displayed based on the same vertical and horizontal axes.

[0075] Specifically, the images representing the sensor value data are overlaid on the display section 33 by plotting each sensor value in the same analysis time range obtained by performing the five analyses of Measurement 1 to Measurement 5 at fixed intervals (for example, every 0.5 min) with the vacuum degree as the vertical axis and the analysis time as the horizontal axis. However, the vertical axis is not limited to the vacuum degree, and can be another sensor value such as the interface current.

[0076] The "same analysis time range" can be the entire time range from the start to the end of the analysis, or a partial time range. In the case of a partial time range, it can be an arbitrary time range in the analysis, or a time range set in advance.

[0077] Based on the images illustrated above, the state of the analysis device 100 can be determined. For example, the user can determine the state of the analysis device 100 by visually observing the images, or can determine the state of the analysis device 100 by image processing. As the above image processing, a process of comparing the peak value or peak area in the image with a threshold value can be exemplified, but is not limited thereto. Figure 5 As described above, the state of the analysis device 100 is determined based on the images illustrated above, and by combining the result of this determination with the result of the processing of the comparison processing section 311, the state of the analysis device 100 can be determined with further higher precision.

[0078] Figure 5

[0079] 6. Another example of the processing of the display processing section

[0080] Figure 6 is a view for explaining another example of the processing of the display processing section 313. In this example, for a plurality of sensor value data obtained by performing a plurality of analyses under the same analysis condition, the display processing section 313 displays an image representing the amount of change in the sensor value at the same analysis time in time series on the display section 33. The "same analysis time" can be an arbitrary time in the analysis, or a time set in advance.

[0081] ​​Specifically, in association with the horizontal axis in which the respective measurements of Measurement 1 to Measurement 4 are arranged in time series, the amount of change in the sensor value with respect to the reference is shown in the vertical axis. As the sensor value, the output value from each of the sensors 1 to 3 is plotted, but the output value from each of the sensors can also be plotted for 2 or fewer sensors, or 4 or more sensors. In addition, as the sensors 1 to 3, the pressure gauge 16, the vacuum gauge 25, or the ammeter 26, or the like can be exemplified.

[0082] Based on Figure 6 The exemplified image enables determination of the state of the analysis device 100. For example, the user can determine the state of the analysis device 100 by visually observing the image, or can determine the state of the analysis device 100 by image processing. As the above image processing, a process of comparing the peak value or the peak area in the image with a threshold value can be exemplified, but is not limited thereto.

[0083] As such, based on Figure 6 the exemplified image determining the state of the analysis device 100, by combining the result of this determination with the result of the processing of the comparison processing section 311, the state of the analysis device 100 can be further accurately determined.

[0084] 7. Modification

[0085] In the above embodiment, the analysis device 100 in which the liquid chromatograph 1 and the mass spectrometer 2 are combined is described. However, the present application can be applied to the analysis device 100 including at least one of a chromatograph and a mass spectrometer. Therefore, the analysis device 100 can also be a device in which a gas chromatograph and a mass spectrometer are combined. In addition, the analysis device 100 can be a device constituted only by a liquid chromatograph or a gas chromatograph, or can be a device constituted only by a mass spectrometer.

[0086] As for the sensor value data to be compared, the processing of the comparison processing section 311 can be performed after the analysis by reading out from the storage section 32, or can be performed in real time during the analysis by reading out from the storage section 32.

[0087] The sensor value data is not limited to the pump pressure detected by the pressure gauge 16, the vacuum degree detected by the vacuum gauge 25, or the interface current detected by the ammeter 26, but can also be constituted by the output value from various other sensors.

[0088] 8. Scheme

[0089] Those skilled in the art will appreciate that the above-described multiple exemplary embodiments are specific examples of the following scheme.

[0090] (1) An analysis device according to a first aspect includes at least one of a chromatograph and a mass spectrometer, and can include:

[0091] a sensor that detects a state of the analysis device and outputs a sensor value corresponding to the state;

[0092] a storage unit that stores sensor value data indicating a temporal change in the sensor value over time;

[0093] a comparison processing unit that compares, for a plurality of pieces of the sensor value data obtained by performing multiple analyses under the same analysis conditions, a difference in the sensor value at the same analysis time or a difference in a value indicating a change in the sensor value within the same analysis time range with a threshold value.

[0094] According to the analysis device according to the first aspect, instead of comparing the sensor value with the threshold value, for a plurality of pieces of the sensor value data obtained by performing multiple analyses under the same analysis conditions, by comparing a difference in the sensor value at the same analysis time or a difference in a value indicating a change in the sensor value within the same analysis time range with the threshold value, the state of the analysis device can be determined with higher accuracy. That is, even in a case where the state of the analysis device is abnormal, but is determined to be normal by comparing the sensor value with the threshold value, by comparing a difference in the sensor value or a difference in a value indicating a change in the sensor value with the threshold value, the state of the analysis device can be determined to be abnormal with high accuracy.

[0095] (2) An analysis device according to a second aspect includes at least one of a chromatograph and a mass spectrometer, and can include:

[0096] a sensor that detects a state of the analysis device and outputs a sensor value corresponding to the state;

[0097] a storage unit that stores sensor value data indicating a temporal change in the sensor value over time;

[0098] a comparison processing unit that compares, for a plurality of pieces of the sensor value data obtained by performing multiple analyses under the same analysis conditions, a difference in a graph of each piece of the sensor value data within the same analysis time range with a threshold value.

[0099] According to the analysis device of item 2, instead of comparing the sensor value with the threshold value, by comparing the difference of the images representing each sensor value data within the same analysis time range with the threshold value for a plurality of sensor value data obtained by performing a plurality of analyses under the same analysis condition, the state of the analysis device can be determined with higher accuracy. That is, even in a case where the analysis device is abnormal, by comparing the difference of the images representing each sensor value data with the threshold value, the state of the analysis device can be determined with high accuracy as abnormal even in a case where it is determined as normal by comparing the sensor value with the threshold value.

[0100] (3) In the analysis device according to item 1 or 2, it can be that

[0101] Further, a reporting processing section reports abnormality of the analysis device based on the comparison result of the comparison processing section.

[0102] According to the analysis device of item 3, in a case where the state of the analysis device is determined as abnormal, the case is reported to the user. Thus, the user can be easily informed of the case where accurate analysis result is not obtained.

[0103] (4) In the analysis device according to item 1 or 2, it can be that

[0104] Further, a display processing section superimposes and displays images representing each sensor value data within the same analysis time range for a plurality of the sensor value data obtained by performing a plurality of analyses under the same analysis condition.

[0105] According to the analysis device of item 4, by superimposing and displaying the images representing each sensor value data within the same analysis time range, the state of the analysis device can be determined based on the images. By combining the determination result with the processing result of the comparison processing section, the state of the analysis device can be further determined with higher accuracy.

[0106] (5) In the analysis device according to item 1 or 2, it can be that

[0107] Further, a display processing section displays images representing the amount of change of the sensor value at the same analysis time in time series for a plurality of the sensor value data obtained by performing a plurality of analyses under the same analysis condition.

[0108] According to the analysis device of item 5, by displaying the images representing the amount of change of the sensor value at the same analysis time in time series, the state of the analysis device can be determined based on the images. By combining the determination result with the processing result of the comparison processing section, the state of the analysis device can be further determined with higher accuracy.

[0109] Explanation of Reference Signs

[0110] 1 liquid chromatograph

[0111] 2 mass spectrometer

[0112] 3 control device

[0113] 16 pressure gauge

[0114] 25 vacuum gauge

[0115] 26 ammeter

[0116] 31 control section

[0117] 32 storage section

[0118] 33 display section

[0119] 100 analysis device

[0120] 311 comparison processing section

[0121] 312 report processing section

[0122] 313 display processing section

Claims

1. An analytical apparatus comprising at least one of a chromatograph and a mass analysis device, characterized in that, have: A sensor detects the state of the analysis device and outputs a sensor value corresponding to that state. The storage unit stores sensor value data, which represents the temporal change of the sensor values ​​over the course of the analysis period. The comparison processing unit compares the difference between the sensor values ​​at the same analysis time, or the difference of the value representing the change of the sensor values ​​within the same analysis time range, with a threshold for multiple sensor value data obtained by performing multiple analyses under the same analysis conditions.

2. An analytical apparatus comprising at least one of a chromatograph and a mass analysis device, characterized in that, have: A sensor detects the state of the analysis device and outputs a sensor value corresponding to that state. The storage unit stores sensor value data, which represents the temporal change of the sensor values ​​over the course of the analysis period. The comparison processing unit compares the difference between the images representing the sensor value data within the same analysis time range with a threshold for multiple sensor value data obtained by performing multiple analyses under the same analysis conditions.

3. The analytical apparatus as described in claim 1 or 2, characterized in that, Furthermore, it includes a report processing unit that reports any abnormalities in the analysis device based on the comparison results from the comparison processing unit.

4. The analytical apparatus as described in claim 1 or 2, characterized in that, Furthermore, it includes a display processing unit that overlays images representing the sensor value data within the same analysis time range for multiple sensor value data obtained by performing multiple analyses under the same analysis conditions.

5. The analytical apparatus as described in claim 1 or 2, characterized in that, It further includes a display processing unit that displays an image representing the change in the sensor values ​​over the same analysis time, based on multiple sensor value data obtained through multiple analyses under the same analysis conditions.

Images