Edible and medicinal composition oral thick paste with efficacy of reducing hypertension, hyperglycemia and hyperlipidemia and preparation method of edible and medicinal composition oral thick paste

Abstract

The invention discloses an edible and medicinal composition oral thick paste with efficacy of reducing hypertension, hyperglycemia and hyperlipidemia and a preparation method thereof, and belongs to the technical field of health-care food, the oral thick paste comprises the following components in percentage by weight: 50% of tangerine, platycodon grandiflorum, pericarpium citri reticulatae, allium macrostemon, kelp, semen brassicae and selfheal; 30% of abelmoschus esculentus, cassia seed, trichosanthes kirilowii maxim, gardenia, sophora flower and mulberry leaf; 20% of Poria cocos, Radix Puerariae, white hyacinth bean, Hericium erinaceus, raw licorice, honey, and potassium sorbate with the addition amount not exceeding 0.1% of the weight of the concentrate. The preparation method comprises the following steps: proportioning the raw materials in proportion, decocting the medicinal materials with clean water, performing negative-pressure low-temperature concentration on decoction, and finally adding auxiliary materials and stirring for dissolving. The oral thick paste can specifically improve cell membrane substance exchange barrier in body tissue cell microcirculation and promote cell metabolism, and the core mechanism acts on the essence of the three-high problem, so that the oral thick paste takes effect within one hour after being taken by people suffering from the three-high, and is safe and free of side effects.

Description

Technical Field

[0001] This invention relates to the field of health food technology, and in particular to a food and medicine homologous composition paste with the effect of lowering blood pressure, blood sugar, and cholesterol, and its preparation method. Background Technology

[0002] Hypertension, hyperglycemia, and hyperlipidemia are the most common chronic metabolic diseases in clinical practice, with a persistently high incidence rate among middle-aged and elderly populations. In recent years, they have shown a trend of affecting younger people due to changes in lifestyle. As core risk factors for cardiovascular and cerebrovascular diseases, chronic kidney disease, and peripheral vascular disease, if the "three highs" are not well controlled in the long term, they will gradually damage the function of important target organs such as the heart, brain, and kidneys, not only reducing patients' quality of life but also potentially triggering acute complications that endanger life. They have become one of the major public health problems affecting national health.

[0003] In clinical interventions for hypertension, hyperlipidemia, and hyperglycemia, treatment often relies on chemical drugs such as antihypertensive drugs, hypoglycemic drugs, and lipid-lowering drugs for symptomatic relief. While these drugs can quickly lower the levels, long-term use can easily lead to side effects such as increased metabolic burden on the liver and kidneys, gastrointestinal discomfort, and electrolyte imbalances. On the other hand, while lifestyle interventions have no side effects, they are slow to take effect, require long-term adherence, and have poor patient compliance, making it difficult to meet the public's demand for a "safe, efficient, and gentle" approach to managing hypertension, hyperlipidemia, and hyperglycemia.

[0004] Traditional Chinese medicine pastes, or "gaozi," are one of the eight major dosage forms in traditional Chinese medicine, with a long history of use. They are characterized by their nourishing, health-preserving, strengthening, anti-aging, and longevity-promoting properties. Despite their benefits, the complex manufacturing process of gaozi has led to its near extinction. Gaozi are made by decocting and concentrating health-preserving ingredients or by decocting Chinese herbs with water, filtering the residue, concentrating the liquid, and then adding excipients such as honey to create a paste-like consistency. Primarily nourishing, they also offer a slow therapeutic effect. Their palatable taste makes them popular with patients. As an important component of the traditional Chinese medicine system of "gao, dan, wan, san" (paste, pill, powder), gaozi leverages the natural properties of food and medicine homologous materials, offering natural advantages in regulating sub-health conditions and improving chronic health issues such as hypertension, hyperlipidemia, and hyperglycemia. This aligns particularly well with the modern population's demand for safe and gentle health interventions.

[0005] However, current traditional Chinese medicine (TCM) paste formulations lack scientific basis, with chaotic ingredient ratios and unbalanced combinations of core active ingredients. The preparation processes are also significantly flawed, ranging from arbitrary raw material selection to lack of standardized temperature and time control during decoction, and missing parameters in the concentration process. This results in insufficient dissolution of active ingredients and poor stability. Furthermore, the lack of standards for excipient addition in some products further hinders efficacy. These problems directly lead to unclear and unstable therapeutic effects in existing paste products. There is an urgent need for a scientifically precise, well-regulated, and safe food-medicine homologous composition paste to address the shortcomings of existing products and meet the public's demand for safe and effective treatment of hypertension, hyperlipidemia, and hyperglycemia. Summary of the Invention

[0006] The purpose of this invention is to provide a food-medicine homologous composition paste with the effect of lowering blood pressure, blood sugar, and cholesterol, and its preparation method, in order to solve the above-mentioned problems.

[0007] This invention provides a food-medicine homologous composition paste with the effect of lowering blood pressure, blood sugar, and cholesterol. The raw materials, by weight percentage, include the following components: Citrus reticulata peel 6%–8%, Platycodon grandiflorus 6%–8%, Citrus reticulata peel 6%–8%, Allium macrostemon 6%–8%, Laminaria japonica 6%–8%, Sinapis alba 6%–8%, Prunella vulgaris 6%–8%, the above components account for 50% of the total raw material components; Okra 4%–6%, Cassia seed 4%–6%, Cucurbita 4%–6%, Gardenia 4%–6%, Sophora japonica flower 4%–6%, Mulberry leaf 4%–6%, the above components account for 30% of the total raw material components; Poria cocos 3%–4%, kudzu root 3%–4%, white hyacinth bean 3%–4%, Hericium erinaceus 3%–4%, raw licorice root 3%–4%, honey 3%–4%, and potassium sorbate, wherein the amount of potassium sorbate added does not exceed 0.1% of the weight of the concentrated liquid during the preparation of the paste, and the above components account for 20% of the total raw material components; Honey and potassium sorbate are used as auxiliary ingredients.

[0008] A method for preparing the above-mentioned food-medicine homologous composition paste with the effect of lowering blood pressure, blood sugar, and cholesterol includes the following steps: 1) Ingredients: Weigh each raw material except for auxiliary materials according to the weight percentage, with the weight error of the raw materials not exceeding 2%; clean the raw materials with impurities on the surface and drain them for later use; 2) Adding and simmering: Put the raw materials prepared in step 1) into the simmering container and add an appropriate amount of clean water; the raw materials can be pre-soaked before simmering or simmered directly; heat until the soup boils and continue to simmer for a certain period of time; if the raw materials are finely ground, they need to be divided into portions before being put into the simmering container, and the raw materials should be turned regularly during the simmering process to prevent clumping. 3) Concentration: After decoction, filter the liquid to remove dregs, and transfer the filtered clear liquid to a concentration pot; use a negative pressure low temperature concentration process; when the liquid reaches the preset concentration, stop the concentration to obtain concentrated liquid; 4) Add excipients: Add honey and potassium sorbate to the concentrate obtained in step 3); stir thoroughly until all excipients are completely dissolved, cover and let cool naturally to obtain the food and medicine homologous composition paste with the effect of lowering blood pressure, blood sugar, and cholesterol.

[0009] Preferably, in the preparation method of the above-mentioned food and medicine homologous composition paste with the effect of lowering blood pressure, blood sugar, and cholesterol, in step 1), the raw materials with impurities attached to the surface include tangerine peel, platycodon root, dried tangerine peel, allium macrostemon, kelp, prunella vulgaris, okra, cassia seed, trichosanthes kirilowii, gardenia, sophora japonica flower, mulberry leaf, poria cocos, kudzu root, white hyacinth bean, monkey head mushroom, and raw licorice.

[0010] Preferably, in the above-mentioned method for preparing a food and medicine homologous composition paste with the effect of lowering blood pressure, blood sugar, and cholesterol, in step 2), the amount of purified water added is 8-10 times the total weight of the raw materials; drinking water is used as the soaking liquid when the raw materials are pre-soaked, the soaking time is 1 hour, and the raw materials are kept completely submerged in the soaking liquid during the soaking process. After soaking, the soaking liquid is not discarded, but is put into the decoction cylinder along with the raw materials.

[0011] Preferably, in the above-mentioned method for preparing a food and medicine homologous composition paste with the effect of lowering blood pressure, blood sugar, and cholesterol, in step 2), the temperature of the liquid in the material cylinder is heated to not exceed 100°C; the packaging specification of the finely pulverized raw materials is not more than 250g per package.

[0012] Preferably, in the preparation method of the above-mentioned food and medicine homologous composition paste with the effect of lowering blood pressure, blood sugar, and cholesterol, in step 2), if a two-stage decoction process is adopted, the decoction is boiled for 60 minutes after each boiling. After the first decoction, the first decoction is filtered and collected. Then, 5-8 times the total weight of the raw materials is added to the filtered residue, and the decoction operation is repeated. The second decoction is then filtered and collected. The first and second decoctions are combined as the decoction to be concentrated in step 3). If a single-stage decoction process is adopted, the decoction is boiled for 120 minutes after boiling.

[0013] Preferably, in the above-mentioned method for preparing a medicinal paste with the effect of lowering blood pressure, blood sugar, and cholesterol, in step 3), a 100-mesh filter is used for filtration; in the negative pressure low-temperature concentration process, the negative pressure of the concentration pot is controlled to be greater than 0.06 MPa and the temperature inside the pot is not higher than 75°C; when the liquid level in the concentration pot drops to about 1 / 4, 30-50 ml of medicinal liquid is extracted to measure the concentration of the decoction, and the concentration of the decoction is measured using a Baumé meter until the concentration stabilizes at 20-22 Baumé degrees, and then the concentration is stopped.

[0014] Therefore, this invention employs the aforementioned food-medicine homologous composition paste with the efficacy of lowering the three highs (high blood pressure, high blood sugar, and high cholesterol) and its preparation method. The food-medicine homologous raw materials are precisely divided according to function and proportion, with each component having a clear ratio and synergistic effect. This can specifically improve the cell membrane substance exchange barrier in the microcirculation of body tissue cells and promote cell metabolism. This core mechanism directly addresses the essence of the three highs problem, enabling people with the three highs to experience a general reduction in key indicators such as blood pressure, heart rate, total cholesterol, low-density lipoprotein, uric acid, blood sugar, and triglycerides within one hour of taking the paste. Furthermore, these indicators continue to decrease within 1.0-4.0 hours. The overall efficacy in lowering the three highs is significantly superior to existing similar products and some drugs, achieving the advantages of rapid onset, sustained and stable effects, and wide applicability. By strictly controlling the weight error of raw materials, standardizing decoction parameters, and adopting processes such as negative pressure low-temperature concentration and filter filtration, the effective active ingredients in the raw materials are preserved to the maximum extent, and the damage of efficacy components to high temperatures is avoided. At the same time, the amount of potassium sorbate added is strictly controlled within 0.1% of the weight of the concentrated liquid, ensuring both the product's preservative effect and food safety, ultimately achieving definite product efficacy and stable quality.

[0015] The technical solution of the present invention will be further described in detail below through embodiments. Detailed Implementation

[0016] To better understand the above technical solutions, a detailed description of the specific implementation methods will be provided below. Obviously, the described embodiments are merely some, not all, of the embodiments of the present invention. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without creative effort are within the scope of protection of the present invention.

[0017] The terminology used in the embodiments of this invention is for the purpose of describing particular embodiments only and is not intended to limit the invention. The singular forms “a,” “the,” and “the” as used in the embodiments of this invention and the appended claims are also intended to include the plural forms, and “multiple” generally includes at least two unless the context clearly indicates otherwise.

[0018] It should also be noted that the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that an article or device that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such an article or device. Without further limitation, an element defined by the phrase "comprising one..." does not exclude the presence of other identical elements in the article or device that includes said element.

[0019] This invention provides a food-medicine homologous composition paste with the effect of lowering blood pressure, blood sugar, and cholesterol. The raw materials, by weight percentage, include the following components: Citrus reticulata peel 6%–8%, Platycodon grandiflorus 6%–8%, Citrus reticulata peel 6%–8%, Allium macrostemon 6%–8%, Laminaria japonica 6%–8%, Sinapis alba 6%–8%, Prunella vulgaris 6%–8%, the above components account for 50% of the total raw material components; Okra 4%–6%, Cassia seed 4%–6%, Cucurbita 4%–6%, Gardenia 4%–6%, Sophora japonica flower 4%–6%, Mulberry leaf 4%–6%, the above components account for 30% of the total raw material components; Poria cocos 3%–4%, kudzu root 3%–4%, white hyacinth bean 3%–4%, Hericium erinaceus 3%–4%, raw licorice root 3%–4%, honey 3%–4%, and potassium sorbate, wherein the amount of potassium sorbate added does not exceed 0.1% of the weight of the concentrated liquid during the preparation of the paste, and the above components account for 20% of the total raw material components; Honey and potassium sorbate are used as auxiliary ingredients.

[0020] A method for preparing the above-mentioned food-medicine homologous composition paste with the effect of lowering blood pressure, blood sugar, and cholesterol includes the following steps: 1) Ingredients: Weigh each raw material except for auxiliary materials according to the weight percentage, with the weight error of the raw materials not exceeding 2%; clean the raw materials with impurities on the surface and drain them for later use; 2) Adding and simmering: Put the raw materials prepared in step 1) into the simmering container and add an appropriate amount of clean water; the raw materials can be pre-soaked before simmering or simmered directly; heat until the soup boils and continue to simmer for a certain period of time; if the raw materials are finely ground, they need to be divided into portions before being put into the simmering container, and the raw materials should be turned regularly during the simmering process to prevent clumping. 3) Concentration: After decoction, filter the liquid to remove dregs, and transfer the filtered clear liquid to a concentration pot; use a negative pressure low temperature concentration process; when the liquid reaches the preset concentration, stop the concentration to obtain concentrated liquid; 4) Add excipients: Add honey and potassium sorbate to the concentrate obtained in step 3); stir thoroughly until all excipients are completely dissolved, cover and let cool naturally to obtain the food and medicine homologous composition paste with the effect of lowering blood pressure, blood sugar, and cholesterol.

[0021] To further optimize the above technical solution, in step 1), the raw materials with surface impurities include tangerine peel, platycodon root, dried tangerine peel, allium macrostemon, kelp, prunella vulgaris, okra, cassia seed, trichosanthes kirilowii, gardenia, sophora japonica flower, mulberry leaf, poria cocos, kudzu root, white hyacinth bean, monkey head mushroom, and raw licorice.

[0022] To further optimize the above technical solution, in step 2), the amount of purified water added is 8-10 times the total weight of the raw materials; drinking water is used as the soaking solution when the raw materials are pre-soaked, the soaking time is 1 hour, and the raw materials are kept completely submerged in the soaking solution during the soaking process. After soaking, the soaking solution is not discarded, but is put into the decoction cylinder along with the raw materials.

[0023] To further optimize the above technical solution, in step 2), the temperature of the liquid in the material barrel is heated to not exceed 100℃; the packaging specifications of the finely pulverized raw materials are not more than 250g per package.

[0024] To further optimize the above technical solution, in step 2), if a two-stage decoction process is adopted, the decoction is boiled for 60 minutes after each boiling. After the first decoction, the first decoction is filtered and collected. Then, 5-8 times the total weight of the raw materials is added to the filtered residue. The decoction process is repeated, and the second decoction is filtered and collected. The first and second decoctions are combined as the decoction to be concentrated in step 3). If a single-stage decoction process is adopted, the decoction is boiled for 120 minutes after boiling.

[0025] To further optimize the above technical solution, in step 3), a 100-mesh filter is used for filtration; in the negative pressure low-temperature concentration process, the negative pressure of the concentration pot is controlled to be greater than 0.06 MPa and the temperature inside the pot is not higher than 75°C; when the liquid level in the concentration pot drops to about 1 / 4, 30-50 ml of the medicine solution is extracted to measure the concentration of the decoction, and the concentration of the decoction is measured using a Baumé meter until the concentration stabilizes at 20-22 Baumé degrees, at which point the concentration is stopped.

[0026] To more clearly and in detail introduce the food and medicine homologous composition paste with the effect of lowering blood pressure, blood sugar, and cholesterol provided in the embodiments of the present invention and its preparation method, the following will describe it in conjunction with specific embodiments.

[0027] Example 1 The total weight of the raw materials prepared for the food-medicine homology composition paste in this embodiment is 1000g, as follows: The first raw material group accounts for 50% of the total raw material components and includes 72g of tangerine peel, 72g of platycodon root, 72g of dried tangerine peel, 72g of allium macrostemon, 72g of kelp, 72g of white mustard seed, and 72g of prunella vulgaris, which are cleaned and impurities removed before use; the second raw material group accounts for 30% of the total raw material components and includes 50g of okra, 50g of cassia seed, 50g of trichosanthes fruit, 50g of gardenia fruit, 50g of sophora japonica flower, and 50g of mulberry leaf; the third raw material group accounts for 20% of the total raw material components and includes 33g of poria cocos, 33g of kudzu root, 33g of white hyacinth bean, 33g of hericium erinaceus, 33g of raw licorice root, and 33g of honey as excipients; in addition, potassium sorbate is added as a separately specified excipient at 0.1% of the weight of the concentrated liquid.

[0028] The preparation process is as follows: according to the above formula, each raw material is accurately weighed using an electronic platform scale with an accuracy of 0.1g, and the weight error of all raw materials is controlled within 1.5%. The raw materials of tangerine peel, platycodon root, dried tangerine peel, allium macrostemon, kelp, prunella vulgaris, okra, cassia seed, trichosanthes kirilowii, gardenia, sophora japonica flower, mulberry leaf, poria cocos, kudzu root, white hyacinth bean, monkey head mushroom, and raw licorice are rinsed twice with drinking water for 60 seconds each time, and the surface water is drained for later use. The honey and potassium sorbate are placed directly in a clean container for later use.

[0029] Next, proceed to the feeding and decoction step. Put the drained medicinal materials into a 50-liter stainless steel container and add 8 times the total weight of the raw materials in purified water, totaling 8000mL. Then, pre-soak the raw materials at room temperature for 1 hour. The soaking solution is drinking water and the raw materials are completely submerged. Do not discard the soaking solution after soaking; leave it in the container with the raw materials. Heat the container and control the maximum temperature of the decoction to 100℃. After the decoction boils, decoct twice. After the first boil, continue to decoct for 45 minutes. Filter and collect the first decoction through a 100-mesh filter. Add 5 times the total weight of the raw materials in purified water to the filtered residue, and repeat heating to boiling and decoction for 40 minutes. Filter and collect the second decoction. Combine the two decoctions to obtain a clear decoction with a total volume of about 9000mL.

[0030] In the concentration step, the combined clarified liquid was transferred into a vacuum concentrator, and the vacuum pump was turned on to stabilize the negative pressure of the concentrator at 0.07 MPa. The temperature inside the concentrator was controlled at 70°C. During the concentration process, 40 mL of liquid was drawn every 30 minutes, and the concentration was measured with a Baumé meter with an accuracy of 0.1 Bé. The initial concentration was 3 Bé. After 2.5 hours of concentration, the concentration of the liquid reached 21 Bé. Concentration was then stopped, and 2500 g of concentrate was obtained.

[0031] Finally, in the process of adding excipients, the prescribed amount of honey is added to 2500g of concentrate, along with 2.5g of potassium sorbate, and stirred to ensure that all excipients are completely dissolved. The mixture is then allowed to cool naturally to room temperature to obtain a paste containing a food and medicine homology composition that has the effect of lowering blood pressure, blood sugar, and cholesterol. This paste is then packaged and sealed for storage.

[0032] Example 2 The total weight of the raw materials prepared for the food-medicine homology composition paste in this embodiment is 3000g, as follows: The first raw material group accounts for 50% of the total raw material components and includes 215g of tangerine peel, 215g of platycodon root, 215g of dried tangerine peel, 215g of allium macrostemon, 215g of kelp, 215g of white mustard seed, and 215g of prunella vulgaris, which are cleaned and impurities removed before use; the second raw material group accounts for 30% of the total raw material components and includes 150g of okra, 150g of cassia seed, 150g of trichosanthes fruit, 150g of gardenia, 150g of sophora japonica flower, and 150g of mulberry leaf; the third raw material group accounts for 20% of the total raw material components and includes 100g of poria cocos, 100g of kudzu root, 100g of white hyacinth bean, 100g of monkey head mushroom, 100g of raw licorice root, and 100g of honey as excipients; in addition, potassium sorbate is added as a separately specified excipient at 0.1% of the weight of the concentrated liquid.

[0033] The preparation process is as follows: according to the above formula, each raw material is accurately weighed using an electronic platform scale with an accuracy of 0.1g, and the weight error of all raw materials is controlled within 1.5%. The raw materials of tangerine peel, platycodon root, dried tangerine peel, allium macrostemon, kelp, prunella vulgaris, okra, cassia seed, trichosanthes kirilowii, gardenia, sophora japonica flower, mulberry leaf, poria cocos, kudzu root, white hyacinth bean, monkey head mushroom, and raw licorice are rinsed twice with drinking water for 60 seconds each time, and the surface water is drained for later use. The honey and potassium sorbate are placed directly in a clean container for later use.

[0034] Next, proceed to the feeding and decoction step. Put the drained medicinal materials into a 50-liter stainless steel container and add 8 times the total weight of the materials in purified water, totaling 24,000 mL. Then, pre-soak the materials at room temperature for 1 hour. The soaking solution is drinking water and the materials are completely submerged. Do not discard the soaking solution after soaking; leave it in the container with the materials. Heat the container and control the maximum temperature of the decoction to 100℃. After the decoction boils, decoct twice. After the first boil, continue to decoct for 45 minutes. Filter and collect the first decoction through a 100-mesh filter. Add 5 times the total weight of the materials in purified water to the filtered residue, and repeat heating to boiling and decoction for 40 minutes. Filter and collect the second decoction. Combine the two decoctions to obtain a clear decoction with a total volume of approximately 27,000 mL.

[0035] In the concentration step, the combined clarified liquid was transferred into a vacuum concentrator, and the vacuum pump was turned on to stabilize the negative pressure of the concentrator at 0.07 MPa. The temperature inside the concentrator was controlled at 70°C. During the concentration process, 40 mL of liquid was drawn every 30 minutes, and the concentration was measured with a Baumé meter with an accuracy of 0.1 Bé. The initial concentration was 3 Bé. After 2.5 hours of concentration, the concentration of the liquid reached 21 Bé. Concentration was then stopped, and 6750 g of concentrate was obtained.

[0036] Finally, the auxiliary materials are added. The prescribed amount of honey is added to 6750g of concentrate, along with 6.75g of potassium sorbate. Stir to ensure that all auxiliary materials are completely dissolved, and let it cool naturally to room temperature to obtain a food and medicine homologous composition paste with the effect of lowering blood pressure, blood sugar, and cholesterol. It is then packaged and sealed for storage.

[0037] Example 3 The total weight of the raw materials prepared for the food-medicine homology composition paste in this embodiment is 5000g, as follows: The first raw material group accounts for 50% of the total raw material components and includes 355g of tangerine peel, 355g of platycodon root, 355g of dried tangerine peel, 355g of allium macrostemon, 355g of kelp, 355g of white mustard seed, and 355g of prunella vulgaris, which are cleaned and impurities removed before use; the second raw material group accounts for 30% of the total raw material components and includes 250g of okra, 250g of cassia seed, 250g of trichosanthes fruit, 250g of gardenia fruit, 250g of sophora japonica flower, and 250g of mulberry leaf; the third raw material group accounts for 20% of the total raw material components and includes 168g of poria cocos, 168g of kudzu root, 168g of white hyacinth bean, 168g of monkey head mushroom, 168g of raw licorice root, and 168g of honey as excipients; in addition, potassium sorbate is added as a separately specified excipient at 0.1% of the weight of the concentrated liquid.

[0038] The preparation process is as follows: according to the above formula, each raw material is accurately weighed using an electronic platform scale with an accuracy of 0.1g, and the weight error of all raw materials is controlled within 1.5%. The raw materials of tangerine peel, platycodon root, dried tangerine peel, allium macrostemon, kelp, prunella vulgaris, okra, cassia seed, trichosanthes kirilowii, gardenia, sophora japonica flower, mulberry leaf, poria cocos, kudzu root, white hyacinth bean, monkey head mushroom, and raw licorice are rinsed twice with drinking water for 60 seconds each time, and the surface water is drained for later use. The honey and potassium sorbate are placed directly in a clean container for later use.

[0039] Next, proceed to the decoction step. Put the drained medicinal materials into a 50-liter stainless steel container and add 8 times the total weight of the materials in purified water, totaling 40,000 mL. Then, pre-soak the materials at room temperature for 1 hour. The soaking solution is drinking water and the materials are completely submerged. Do not discard the soaking solution after soaking; leave it in the container with the materials. Heat the container and control the maximum temperature of the decoction to 100°C. After the decoction boils, decoct twice. After the first boil, continue to decoct for 45 minutes. Filter and collect the first decoction through a 100-mesh filter. Add 5 times the total weight of the materials in purified water to the filtered residue, and repeat heating to boiling and decoction for 40 minutes. Filter and collect the second decoction. Combine the two decoctions to obtain a clear decoction with a total volume of approximately 45,000 mL.

[0040] In the concentration step, the combined clarified liquid was transferred into a vacuum concentrator, and the vacuum pump was turned on to stabilize the negative pressure of the concentrator at 0.07 MPa. The temperature inside the concentrator was controlled at 70°C. During the concentration process, 40 mL of liquid was drawn every 30 minutes, and the concentration was measured with a Baumé meter with an accuracy of 0.1 Bé. The initial concentration was 3 Bé. After 2.5 hours of concentration, the concentration of the liquid reached 21 Bé. Concentration was then stopped, and 11250 g of concentrate was obtained.

[0041] Finally, in the process of adding excipients, the prescribed amount of honey is added to 11250g of concentrate, along with 11.25g of potassium sorbate. Stir to ensure that all excipients are completely dissolved, and let it cool naturally to room temperature to obtain a food and medicine homologous composition paste with the effect of lowering blood pressure, blood sugar, and cholesterol. It is then packaged and sealed for storage.

[0042] The results of testing and efficacy verification of the product from Example 1 above are as follows.

[0043] In terms of sensory indicators, the paste is brownish-brown with a uniform color and no obvious color difference. It has a complex aroma of dried tangerine peel and honey, no bitter taste of medicinal herbs, a mellow taste without any off-flavors, and is a thick semi-fluid with moderate fluidity. It has no layering or sedimentation and no visible foreign impurities, which meets the consumption requirements of a paste for lowering blood pressure, blood sugar, and cholesterol.

[0044] The efficacy verification involved 20 volunteers who met the diagnostic criteria for "three highs" (hypertension, hyperlipidemia, and hyperglycemia): systolic blood pressure ≥140 mmHg, fasting blood glucose ≥7.0 mmol / L, and total cholesterol ≥5.2 mmol / L. The volunteers were aged 35-65 years, with 10 males and 10 females. Those with severe liver or kidney dysfunction were excluded, and the volunteers had not previously taken any related Western medications or had taken them for no more than 90 days. Volunteers took 15g twice daily, morning and evening, with warm water. During the treatment, they maintained a regular diet, without adjusting their existing antihypertensive / hyperglycemic / lipid-lowering medication dosages, and required no special dietary restrictions or additional treatments or interventions. Systolic blood pressure, fasting blood glucose, and total cholesterol were measured before administration, one hour after administration, one week after administration, and four weeks after administration.

[0045] The test results showed that before taking the medication, the baseline systolic blood pressure was 148.5±5.2 mmHg, fasting blood glucose was 7.8±0.6 mmol / L, and total cholesterol was 5.8±0.4 mmol / L. One hour after taking the medication, the systolic blood pressure dropped to 141.2±4.8 mmHg, fasting blood glucose dropped to 7.3±0.5 mmol / L, and total cholesterol dropped to 5.6±0.3 mmol / L, all indicators showing a rapid onset of action. After one week of taking the medication, the systolic blood pressure was 135.8±4.1 mmHg, fasting blood glucose was 6.9±0.4 mmol / L, and total cholesterol was 5.4±0.3 mmol / L. After four weeks of taking the medication, the systolic blood pressure was 130.2±3.5 mmHg, fasting blood glucose was 6.5±0.3 mmol / L, and total cholesterol was 5.1±0.2 mmol / L, with both blood pressure and cholesterol returning to the normal range. Throughout the verification process, the volunteers experienced no gastrointestinal discomfort, allergies, or other side effects, fully demonstrating that the ointment prepared in this embodiment can safely and effectively reduce the three highs (high blood pressure, high blood sugar, and high cholesterol), solving the problems of ambiguous effects and obvious side effects of existing products.

[0046] Example 4 The raw material formula in this embodiment is exactly the same as that in Example 1, except that the "addition and decoction" step uses a single decoction process. Specifically, after soaking the medicinal materials for 1 hour, add 10 times the total weight of the raw materials in purified water, heat to 95°C and boil for 90 minutes. Filter once through a 100-mesh filter to obtain about 6000mL of decoction. The subsequent concentration and addition of excipients steps are exactly the same as in Example 1.

[0047] Key test and verification results showed that the concentration of the concentrated decoction was 20.5 Bé. For efficacy verification, 20 volunteers meeting the diagnostic criteria for "three highs" (hypertension, hyperlipidemia, and hyperglycemia) were selected: systolic blood pressure ≥140 mmHg, fasting blood glucose ≥7.0 mmol / L, and total cholesterol ≥5.2 mmol / L. The volunteers were aged 45-65 years, with 10 males and 10 females. Those with severe liver or kidney dysfunction were excluded, and they had not previously taken related Western medicines or had taken them for no more than 90 days. The decoction was taken with warm water, and the volunteers maintained a regular diet and did not adjust their existing antihypertensive / hyperglycemic / lipid-lowering medication dosages. Special dietary restrictions or adjuvant treatments / interventions were observed. One hour after administration, systolic blood pressure decreased to 135.2±4.8 mmHg, fasting blood glucose decreased to 6.9±0.5 mmol / L, and total cholesterol decreased to 5.2±0.3 mmol / L, all indicators showing a decrease. After four weeks of administration, systolic blood pressure was 132.5±3.8 mmHg, fasting blood glucose was 6.6±0.3 mmol / L, and total cholesterol was 5.1±0.2 mmol / L. All indicators were better than the baseline levels before administration and had returned to the normal range without any adverse reactions. These results indicate that both the single-decocting process and the two-decocting process in Example 1 can prepare a paste with a clear effect of lowering blood pressure, blood sugar, and cholesterol, proving that the preparation process of this invention has high flexibility and can meet the application needs of different production scenarios according to actual production conditions and efficiency requirements.

[0048] Therefore, this invention employs the aforementioned food-medicine homologous composition paste with the efficacy of lowering the three highs (high blood pressure, high blood sugar, and high cholesterol) and its preparation method. The food-medicine homologous raw materials are precisely divided according to function and proportion, with each component having a clear ratio and synergistic effect. This can specifically improve the cell membrane substance exchange barrier in the microcirculation of body tissue cells and promote cell metabolism. This core mechanism directly addresses the essence of the three highs problem, enabling people with the three highs to experience a general reduction in key indicators such as blood pressure, heart rate, total cholesterol, low-density lipoprotein, uric acid, blood sugar, and triglycerides within one hour of taking the paste. Furthermore, these indicators continue to decrease within 1.0-4.0 hours. The overall efficacy in lowering the three highs is significantly superior to existing similar products and some drugs, achieving the advantages of rapid onset, sustained and stable effects, and wide applicability. By strictly controlling the weight error of raw materials, standardizing decoction parameters, and adopting processes such as negative pressure low-temperature concentration and filter filtration, the effective active ingredients in the raw materials are preserved to the maximum extent, and the damage of efficacy components to high temperatures is avoided. At the same time, the amount of potassium sorbate added is strictly controlled within 0.1% of the weight of the concentrated liquid, ensuring both the product's preservative effect and food safety, ultimately achieving definite product efficacy and stable quality.

[0049] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and not to limit them. Although the present invention has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can still be made to the technical solutions of the present invention, and these modifications or equivalent substitutions cannot cause the modified technical solutions to deviate from the spirit and scope of the technical solutions of the present invention.

Claims

1. A food-medicine homologous composition paste with the effect of lowering blood pressure, blood sugar, and cholesterol, characterized in that, The raw materials, by weight percentage, include the following components: Citrus reticulata peel 6%–8%, Platycodon grandiflorus 6%–8%, Citrus reticulata peel 6%–8%, Allium macrostemon 6%–8%, Laminaria japonica 6%–8%, Sinapis alba 6%–8%, Prunella vulgaris 6%–8%, the above components account for 50% of the total raw material components; Okra 4%–6%, Cassia seed 4%–6%, Cucurbita 4%–6%, Gardenia 4%–6%, Sophora japonica flower 4%–6%, Mulberry leaf 4%–6%, the above components account for 30% of the total raw material components; Poria cocos 3%–4%, kudzu root 3%–4%, white hyacinth bean 3%–4%, Hericium erinaceus 3%–4%, raw licorice root 3%–4%, honey 3%–4%, and potassium sorbate, wherein the amount of potassium sorbate added does not exceed 0.1% of the weight of the concentrated liquid during the preparation of the paste, and the above components account for 20% of the total raw material components; Honey and potassium sorbate are used as auxiliary ingredients.

2. A method for preparing a medicinal paste containing a food-medicine homologous composition as described in claim 1, characterized in that, Includes the following steps: 1) Ingredients: Weigh each raw material except for auxiliary materials according to the weight percentage, with the weight error of the raw materials not exceeding 2%; clean the raw materials with impurities on the surface and drain them for later use; 2) Adding and simmering: Put the raw materials prepared in step 1) into the simmering container and add an appropriate amount of clean water; the raw materials can be pre-soaked before simmering or simmered directly; heat until the soup boils and continue to simmer for a certain period of time; if the raw materials are finely ground, they need to be divided into portions before being put into the simmering container, and the raw materials should be turned regularly during the simmering process to prevent clumping. 3) Concentration: After decoction, filter the liquid to remove dregs, and transfer the filtered clear liquid to a concentration pot; use a negative pressure low temperature concentration process; when the liquid reaches the preset concentration, stop the concentration to obtain concentrated liquid; 4) Add excipients: Add honey and potassium sorbate to the concentrate obtained in step 3); stir thoroughly until all excipients are completely dissolved, cover and let cool naturally to obtain the food and medicine homologous composition paste with the effect of lowering blood pressure, blood sugar, and cholesterol.

3. The method for preparing a medicinal and edible compound paste with the effect of lowering blood pressure, blood sugar, and cholesterol as described in claim 2, characterized in that, In step 1), the raw materials with surface impurities include tangerine peel, platycodon root, dried tangerine peel, allium macrostemon, kelp, prunella vulgaris, okra, cassia seed, trichosanthes kirilowii, gardenia, sophora japonica flower, mulberry leaf, poria cocos, kudzu root, white hyacinth bean, monkey head mushroom, and raw licorice.

4. The method for preparing a medicinal and edible compound paste with the effect of lowering blood pressure, blood sugar, and cholesterol as described in claim 2, characterized in that, In step 2), the amount of purified water added is 8-10 times the total weight of the raw materials; drinking water is used as the soaking solution when pre-soaking the raw materials, the soaking time is 1 hour, and the raw materials are kept completely submerged in the soaking solution during the soaking process. After soaking, the soaking solution is not discarded, but is put into the decoction cylinder along with the raw materials.

5. The method for preparing a medicinal and edible compound paste with the effect of lowering blood pressure, blood sugar, and cholesterol as described in claim 2, characterized in that, In step 2), the temperature of the liquid in the barrel is heated to not exceed 100℃; the packaging specifications of the finely pulverized raw materials are not more than 250g per package.

6. The method for preparing a medicinal paste with the effect of lowering blood pressure, blood sugar, and cholesterol according to claim 2, characterized in that, In step 2), if a two-stage decoction process is used, the decoction is boiled for 60 minutes after each boiling. After the first decoction, the first decoction is filtered and collected. Then, 5-8 times the total weight of the raw materials is added to the filtered dregs and the decoction is repeated. The second decoction is then filtered and collected. The first and second decoctions are combined as the decoction to be concentrated in step 3). If a single-stage decoction process is used, the decoction is boiled for 120 minutes after boiling.

7. The method for preparing a medicinal paste with the effect of lowering blood pressure, blood sugar, and cholesterol according to claim 2, characterized in that, In step 3), a 100-mesh filter is used for filtration; in the negative pressure low-temperature concentration process, the negative pressure of the concentration pot is controlled to be greater than 0.06 MPa and the temperature inside the pot is not higher than 75°C; when the liquid level in the concentration pot drops to about 1 / 4, 30-50 ml of the medicine solution is extracted to measure the concentration of the decoction. The concentration of the decoction is measured using a Baumé meter until the concentration stabilizes at 20-22 Baumé degrees, and then the concentration is stopped.