A composition containing sophorolipids and magnolol, and a preparation method and application thereof

Abstract

The present application provides a kind of composition containing sophorolipid and magnolia alcohol and its preparation method and application, specifically related to daily chemical product technical field.The composition of the present application includes the mass ratio of 1:0.5-2.5:0.8-1.2 sophorolipid, magnolia alcohol and radix bupleuri extract, wherein, radix bupleuri extract is prepared by ultrasonic-assisted low eutectic solvent extraction method, and the obtained radix bupleuri extract has synergistic effect with sophorolipid and magnolia alcohol, can improve the bacteriostatic, anti-inflammatory, moisturizing, soothing effect of composition.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of daily chemical products, and particularly relates to a composition containing sophorolipid and magnolol, a preparation method and application thereof. BACKGROUND

[0002] A large amount of oil and sweat secreted by human skin, and residues of sunscreen and makeup products used in daily life, if not completely cleaned, will accumulate on the skin surface, causing clogging of skin pores and increasing the risk of skin allergies, especially for people with oily skin or prone to acne, which is more likely to induce the formation of acne and acne. Therefore, moderate cleaning is necessary. Common cleaning products can efficiently remove makeup and dirt, but the strong cleaning power can cause skin barrier damage and other problems. Cleaning products with weak cleaning power cannot completely remove sebum, makeup, sunscreen, and environmental particle residues, resulting in acne. Therefore, it is one of the urgent problems to provide a cleaning product with cleaning and acne-removing functions. SUMMARY

[0003] In view of this, a composition containing sophorolipid and magnolol, a preparation method and application thereof are proposed.

[0004] In a first aspect, the present application provides a composition containing sophorolipid and magnolol, which comprises sophorolipid, magnolol and radix bupleuri extract in a mass ratio of 1:0.5-2.5:0.8-1.2.

[0005] Further, the preparation method of the radix bupleuri extract is as follows: crushing dried radix bupleuri to obtain radix bupleuri powder; mixing the radix bupleuri powder with an extraction solvent and performing ultrasonic treatment to obtain an extraction liquid; collecting the supernatant after centrifugation of the extraction liquid, and drying to obtain the radix bupleuri extract.

[0006] The extraction solvent comprises betaine and lactic acid in a molar ratio of 1:1.3-1.8.

[0007] Further, the water content of the extraction solvent is 20-30wt%.

[0008] Further, the solid-liquid ratio of the radix bupleuri powder and the extraction solvent is 1g:10-20mL.

[0009] Further, the ultrasonic treatment has a power of 200-300W, a temperature of 50-60℃, and a time of 15-25min.

[0010] Further, the composition comprises sophorolipid, magnolol and radix bupleuri extract in a mass ratio of 1:2:1.

[0011] In a second aspect, the present application provides a preparation method of the composition of the first aspect, the preparation method comprising the following steps: uniformly mixing raw materials to obtain the composition.

[0012] In a third aspect, the present application provides the use of the composition of the first aspect in the preparation of a cleaning product.

[0013] Further, the composition is used in the cleaning product in an amount of 0.1-10wt%.

[0014] Further, the cleaning product is any one of makeup remover oil, makeup remover cream, facial cleanser, makeup remover water, shampoo, shower gel, soap, and hand sanitizer.

[0015] In the present application,

[0016] Sophorolipid: Sophorolipid is a microbial secondary metabolite produced by fermentation of honey-derived Candida bombicola using sugar and vegetable oil as carbon sources, which has good surface activity and can effectively clean the skin and hair while reducing irritation to the skin.

[0017] Magnolia alcohol: Magnolia alcohol is a polyphenolic substance extracted from Magnolia officinalis, which has certain whitening, antioxidant, anti-inflammatory, soothing and other effects.

[0018] Bletilla striata extract: Bletilla striata contains a large amount of saponins and polyphenolic compounds, which have certain anti-inflammatory, whitening, repair and soothing effects.

[0019] Compared with the prior art, the present application has the following beneficial effects:

[0020] (1) The present application complex sophorolipid, magnolia alcohol and bletilla striata extract into a composition, the composition has good antibacterial, moisturizing, anti-inflammatory effect, adding the composition to the cleaning product, can improve the antibacterial, anti-inflammatory, moisturizing and repair effect of the cleaning product;

[0021] (2) In the preparation method of the bletilla striata extract, betaine is used as a hydrogen bond acceptor and lactic acid is used as a hydrogen bond donor to prepare an extraction solvent. By controlling the water content in the extraction solvent and the extraction process parameters, the plant cell wall of bletilla striata is fully destroyed, and the effective components are better dissolved. The prepared bletilla striata extract has a synergistic effect with sophorolipid and magnolia alcohol, thereby improving the antibacterial, anti-inflammatory, moisturizing and repair effect of the composition. BRIEF DESCRIPTION OF DRAWINGS

[0022] Figure 1 Figure 1 is a comparison chart of the biofilm removal effect of different compositions on propionibacterium acnes in test example 1, wherein A-F are the biofilm removal effect charts of comparison compositions 1-6 on propionibacterium acnes, and G is the biofilm removal effect chart of composition 3 on propionibacterium acnes.

[0023] Figure 2 For test example 5, the application example 1 is prepared for the skin redness improvement of the makeup removing oil contrast chart. DETAILED DESCRIPTION

[0024] In order to make the purpose, technical scheme and effect of the present application more clear and definite, the present application is further described in detail below. It should be understood that the specific embodiments described herein are only used to explain the present application and do not limit the present application.

[0025] The test method used in the examples is a conventional method unless otherwise specified; the materials, reagents, etc. used, unless otherwise specified, can be obtained from commercial channels.

[0026] Sophorolipid is purchased from Bolton (Shanghai) Biotechnology Co., Ltd.;

[0027] Magnolia alcohol is purchased from Hunan and Guangdong Biotechnology Co., Ltd.

[0028] Composition 1

[0029] The composition comprises sophorolipid, magnolia alcohol and radix scrophulariae extract in a mass ratio of 1:0.5:0.8;

[0030] The preparation method of the radix scrophulariae extract comprises the following steps:

[0031] (1) The dried radix scrophulariae is crushed and passed through a 100 mesh sieve to obtain radix scrophulariae powder;

[0032] (2) The radix scrophulariae powder and the extraction solvent are mixed at a solid-liquid ratio of 1g:10mL, and ultrasonic treatment is carried out at a power of 200W and a temperature of 60℃ for 15min to obtain an extraction liquid;

[0033] (3) The extraction liquid is centrifuged at a speed of 10000rpm / min for 3min, and the supernatant is collected and dried to obtain the radix scrophulariae extract;

[0034] The extraction solvent comprises betaine and lactic acid in a molar ratio of 1:1.3, and the water content is 20wt%.

[0035] Composition 2

[0036] The composition comprises sophorolipid, magnolia alcohol and radix scrophulariae extract in a mass ratio of 1:2.5:1.2;

[0037] The preparation method of the radix scrophulariae extract comprises the following steps:

[0038] (1) The dried radix scrophulariae is crushed and passed through a 100 mesh sieve to obtain radix scrophulariae powder;

[0039] (2) The white radix aucklandiae powder and the extraction solvent are mixed according to a material-liquid ratio of 1 g: 20 mL, and are ultrasonically treated under the conditions of a power of 300 W and a temperature of 50 DEG C for 25 min to obtain an extraction liquid;

[0040] (3) The extraction liquid is centrifuged at a speed of 10000 rpm / min for 3 min, and the supernatant is collected and dried to obtain the white radix aucklandiae extract;

[0041] The extraction solvent comprises betaine and lactic acid at a molar ratio of 1:1.8, and has a water content of 30 wt%.

[0042] Composition 3

[0043] The composition comprises sophorolipid, magnolia alcohol and white radix aucklandiae extract at a mass ratio of 1:2:1.

[0044] The preparation method of the white radix aucklandiae extract comprises the following steps:

[0045] (1) Dry white radix aucklandiae is crushed and passed through a 100-mesh sieve to obtain white radix aucklandiae powder;

[0046] (2) The white radix aucklandiae powder and the extraction solvent are mixed according to a material-liquid ratio of 1 g: 15 mL, and are ultrasonically treated under the conditions of a power of 250 W and a temperature of 55 DEG C for 20 min to obtain an extraction liquid;

[0047] (3) The extraction liquid is centrifuged at a speed of 10000 rpm / min for 3 min, and the supernatant is collected and dried to obtain the white radix aucklandiae extract;

[0048] The extraction solvent comprises betaine and lactic acid at a molar ratio of 1:1.5, and has a water content of 25 wt%.

[0049] Comparative composition 1

[0050] Compared with composition 3, comparative composition 1 lacks sophorolipid, and the lack is made up by magnolia alcohol and white radix aucklandiae extract at a mass ratio of 2:1.

[0051] Comparative composition 2

[0052] Compared with composition 3, comparative composition 2 lacks white radix aucklandiae extract, and the lack is made up by sophorolipid and magnolia alcohol at a mass ratio of 1:2.

[0053] Comparative composition 3

[0054] Compared with composition 3, comparative composition 3 lacks magnolia alcohol, and the lack is made up by sophorolipid and white radix aucklandiae extract at a mass ratio of 1:1.

[0055] Comparative composition 4

[0056] Comparative composition 4 includes sophorose lipids, magnolia alcohol and radix haleniae extract in a mass ratio of 1:3:1, compared with composition 3.

[0057] Comparative composition 5

[0058] The difference between comparative composition 5 and composition 3 is only that the extraction solvent used in the preparation method of radix haleniae extract is different, which includes choline chloride and lactic acid in a molar ratio of 1:1.5, with a water content of 25wt%; the rest of the steps are the same as the preparation method of radix haleniae extract in composition 3.

[0059] Comparative composition 6

[0060] The difference between comparative composition 6 and composition 3 is only that the extraction solvent used in the preparation method of radix haleniae extract is different, which includes betaine and lactic acid in a molar ratio of 1.5:1, with a water content of 25wt%; the rest of the steps are the same as the preparation method of radix haleniae extract in composition 3.

[0061] Test example 1

[0062] Compositions 1-3 and comparative compositions 1-6 are prepared into test sample solutions with a concentration of 0.01g / mL; the preparation method of the test sample solution is as follows:

[0063] The preparation method of the test sample solution of compositions 1-3 and comparative compositions 4-6 is as follows: first, dissolve the magnolia alcohol with Tween-85, then add the radix haleniae extract and sophorose lipids, and finally add deionized water to dilute the composition to the final concentration;

[0064] The preparation method of the test sample solution of comparative composition 1 is as follows: first, dissolve the magnolia alcohol with Tween-85, then add the radix haleniae extract, and finally add deionized water to dilute the composition to the final concentration;

[0065] The preparation method of the test sample solution of comparative composition 2 is as follows: first, dissolve the magnolia alcohol with Tween-85, then add the sophorose lipids, and finally add deionized water to dilute the composition to the final concentration;

[0066] The preparation method of the test sample solution of comparative composition 3 is as follows: dilute the radix haleniae extract and sophorose lipids with deionized water to the final concentration;

[0067] The test sample solution is subjected to antibacterial test, and the test strains are Staphylococcus aureus and Escherichia coli.

[0068] Test steps:

[0069] (1) Preparation of antibacterial discs: take sterile filter paper discs, add 20 μL of test sample solution to each filter paper disc, and place the filter paper discs flat in a clean sterile petri dish, and bake in a 37℃ incubator for drying, ready for use;

[0070] (2) Inoculation of test bacteria: a sterile cotton swab was used to dip a test bacteria suspension with a concentration of 5x10 5 CFU / mL~5x10 6 CFU / mL, and was applied to the surface of a nutrient agar culture medium plate, 1 application per time, the plate was rotated by 60 degrees, and was uniformly applied 3 times, and finally the cotton swab was applied around the edge of the plate, and was left to dry at room temperature for 5 min.

[0071] (3) Paste application of bacteriostatic sheets: a sterile forceps was used to take the bacteriostatic sheets and apply them to the surface of the plate, 4 bacteriostatic sheets were applied to each plate, the centers of the bacteriostatic sheets were separated by more than 25 mm, and the bacteriostatic sheets were separated from the edge of the plate by more than 15 mm. After application, the sample sheets were tightly attached to the surface of the plate using a sterile forceps. The plate was covered, and was cultured in a 37℃ incubator for 16h~18h.

[0072] (4) Measurement of bacteriostatic diameters: a uniform and completely sterile bacteriostatic ring was selected, the diameter of the bacteriostatic ring was measured using a vernier caliper, and was recorded, the bacteriostatic ring diameter was measured with the outer edge of the bacteriostatic ring as the boundary, the test was repeated 3 times, and the average value was taken as the test result, and the test results are shown in Table 1.

[0073] Table 1: Bacteriostatic test results of Staphylococcus aureus and Escherichia coli

[0074] Group Staphylococcus aureus inhibition zone diameter (mm) Escherichia coli inhibition zone diameter (mm) Composition 1 25.1 19.3 Composition 2 25.7 18.9 Composition 3 26.5 19.4 Comparative Composition 1 17.5 10.9 Comparative Composition 2 13.7 13.5 Comparative Composition 3 16.2 11.7 Comparative Composition 4 19.4 14.1 Comparative Composition 5 23.6 16.2 Comparative Composition 6 21.7 17.8

[0075] The test results show that the compositions 1-3 of the present application have good inhibitory effects on Staphylococcus aureus and Escherichia coli.

[0076] By comparing the bacteriostatic test data of the composition 3 and the comparative composition 1-3, it can be known that the sophorolipid, magnolia alcohol and radix bupleuri extract used in the present application have a synergistic effect, and have good inhibitory effects on Staphylococcus aureus and Escherichia coli.

[0077] By comparing the bacteriostatic test data of the composition 3 and the comparative composition 4, it can be known that the sophorolipid, magnolia alcohol and radix bupleuri extract used in the present application are compounded according to a specific mass ratio, which can further improve the inhibitory effect of the composition on Staphylococcus aureus and Escherichia coli.

[0078] By comparing the bacteriostatic test data of the composition 3 and the comparative composition 5-6, it can be known that the preparation method of the radix bupleuri extract of the present application can effectively extract the effective components in the radix bupleuri for inhibiting the growth of Staphylococcus aureus and Escherichia coli, and improve the bacteriostatic effect of the composition.

[0079] Test Example 2: Test for removing Propionibacterium acnes biofilm

[0080] (1) Biofilm preparation: Propionibacterium acnes ATCC 6919 was cultured to OD600 = 1, diluted 1:50, transferred to a 24-well plate, 2 mL per well, and cultured for 5 days.

[0081] (2) Test sample aqueous solution cleaning: The compositions 3 and comparative compositions 1-6 were prepared into a test sample solution with a concentration of 1 ppm; the test sample solution was prepared according to Test Example 1. Pure water was used as a control, the supernatant of the cultured strain culture was aspirated, 100 μL of the above test sample solution or pure water was added, 4 replicates per group, 37°C, 200 rpm shaking bed for 20 min, the above test sample solution or pure water was aspirated, and the pure water was cleaned once.

[0082] (3) Crystal violet staining: one drop of ammonium oxalate crystal violet working solution was added to the above well plate, 500 uL of water was added, and the staining was performed for 2 min, the staining solution was aspirated, and the pure water was cleaned 2-3 times.

[0083] (4) Photographing to record the biofilm residue

[0084] Referring to Figure 1 , figures A-F are the biofilm removal effect diagrams of comparative compositions 1-6 on Propionibacterium acnes, and G is the biofilm removal effect diagram of composition 3 on Propionibacterium acnes.

[0085] Compared with composition 3, one of sophorose lipids, magnolia alcohol and radix scrophulariae extract was missing in comparative compositions 1-3, resulting in a decrease in the biofilm removal effect of the composition on Propionibacterium acnes. The results show that the sophorose lipids, magnolia alcohol and radix scrophulariae extract used in the application have a synergistic effect on the removal of Propionibacterium acnes biofilm, and the simultaneous use of the three can significantly improve the biofilm removal effect of the composition on Propionibacterium acnes.

[0086] Compared with composition 3, the raw material ratio of comparative composition 4 was adjusted, resulting in a decrease in the biofilm removal effect of the composition on Propionibacterium acnes. The results show that the use of the raw materials in the application according to the specific mass ratio can further improve the biofilm removal effect of the composition on Propionibacterium acnes.

[0087] Compared with composition 3, the preparation method of radix scrophulariae extract was adjusted in comparative compositions 5-6, resulting in a decrease in the biofilm removal effect of the composition on Propionibacterium acnes. The results show that the selection of the preparation method of radix scrophulariae extract in the application can make the prepared radix scrophulariae extract contain more effective components for removing Propionibacterium acnes biofilm, thereby improving the biofilm removal effect of the composition on Propionibacterium acnes.

[0088] Application example

[0089] The composition 3, the comparative composition 1-6 are added into the makeup remover oil as active components respectively, which is recorded as application example 1 and comparative application example 1-6, the makeup remover oil includes the following raw materials by weight percentage: 30% ethylhexyl stearate, 15% cetyl alcohol ethylhexanoate, 25% C13-16 isoparaffin, 5% polysorbate-85, 10% sorbeth-30 tetraoleate, 1% active component and the balance deionized water;

[0090] The preparation steps of the makeup remover oil containing the composition 3 and the comparative composition 4-6 are as follows:

[0091] S1: ethylhexyl stearate, cetyl alcohol ethylhexanoate, C13-16 isoparaffin are mixed according to the preset ratio, stirred uniformly at 80℃, and A phase is prepared;

[0092] S2: sorbeth-30 tetraoleate, polysorbate-85, magnolia alcohol are added into A phase, stirred and mixed uniformly, cooled to 50℃, and B phase is prepared;

[0093] S3: sophorose lipid, radix scrophulariae extract, deionized water are added into B phase, stirred and mixed uniformly, cooled, and discharged.

[0094] The preparation steps of the makeup remover oil containing the comparative composition 1 are as follows:

[0095] S1: ethylhexyl stearate, cetyl alcohol ethylhexanoate, C13-16 isoparaffin are mixed according to the preset ratio, stirred uniformly at 80℃, and A phase is prepared;

[0096] S2: sorbeth-30 tetraoleate, polysorbate-85, magnolia alcohol are added into A phase, stirred and mixed uniformly, cooled to 50℃, and B phase is prepared;

[0097] S3: radix scrophulariae extract, deionized water are added into B phase, stirred and mixed uniformly, cooled, and discharged.

[0098] The preparation steps of the makeup remover oil containing the comparative composition 2 are as follows:

[0099] S1: ethylhexyl stearate, cetyl alcohol ethylhexanoate, C13-16 isoparaffin are mixed according to the preset ratio, stirred uniformly at 80℃, and A phase is prepared;

[0100] S2: sorbeth-30 tetraoleate, polysorbate-85, magnolia alcohol are added into A phase, stirred and mixed uniformly, cooled to 50℃, and B phase is prepared;

[0101] S3: sophorose lipid and deionized water are added into B phase, stirred and mixed uniformly, cooled, and discharged.

[0102] The preparation steps of the makeup remover oil containing the comparative composition 3 are as follows:

[0103] S1: ethylhexyl stearate, cetyl alcohol ethylhexanoate, C13-16 isoparaffin were mixed in a predetermined ratio, heated to 80°C and stirred until uniform to obtain phase A;

[0104] S2: sorbitan polyether-30 tetraoleate, polysorbate-85 were added to phase A, stirred and mixed until uniform, and cooled to 50°C to obtain phase B;

[0105] S3: sophorolipid, radix anemarrhenae extract, and deionized water were added to phase B, stirred and mixed until uniform, cooled, and discharged.

[0106] Test Example 3

[0107] Moisturizing effect test

[0108] Thirty-five volunteers were randomly selected, aged 22-35 years old, and divided into 7 groups, with 5 people in each group. The face was washed with clean water, the water on the face was wiped clean with a paper towel, and the moisture content of the skin before makeup was detected. After the detection was completed, the face was applied with foundation, eyebrow pencil, eyeliner, lipstick and other cosmetics, and the makeup removal oil of application example 1 and comparative application examples 1-6 was used for makeup removal. Squeeze enough makeup removal oil on the face and circle for 15 s, add water and emulsify for 30 s, then rinse with clean water, and wipe the water on the face with a paper towel. The moisture content of the skin on the face after 5 min of washing was tested by Croneometer CM825, the moisture change rate was calculated, and the experimental results are shown in Table 2.

[0109] Moisture change rate = (moisture content of skin on face after 5 min of washing - moisture content of skin on face before makeup) / moisture content of skin on face before makeup x 100%.

[0110] Table 2 Moisturizing effect test results

[0111] Group Moisture change rate (%) Application Example 1 2.49 Comparative Application Example 1 1.23 Comparative Application Example 2 1.16 Comparative Application Example 3 0.94 Comparative Application Example 4 1.76 Comparative Application Example 5 2.01 Comparative Application Example 6 2.12

[0112] The higher the value of the moisture change rate in Table 2, the better the moisturizing effect of the composition.

[0113] The test results show that the composition of the present application added to the makeup removal oil can quickly clean the face makeup, and at the same time, within 5 min after the makeup removal is completed, the skin moisture is increased compared with the skin moisture before makeup. It shows that using the composition of the present application for cleansing not only has good cleaning effect, but also can supplement the required moisture of the skin, effectively prevent the evaporation of moisture from the skin surface, so as to have the effect of relieving the dryness and tightness of the skin after makeup removal, thereby improving the mildness of the makeup removal oil.

[0114] Compared with application example 1, the raw material composition in the composition is adjusted in comparative application examples 1-4, resulting in the decline of the moisturizing effect of the makeup removing oil, which may be because the sophorolipid, magnolia alcohol and radix bupleuri extract have a synergistic effect, and the addition of the radix bupleuri extract to the washing and caring product can play a moisturizing and repairing role.

[0115] Compared with application example 1, the preparation method of the radix bupleuri extract is adjusted in comparative application examples 5-6, resulting in the decline of the moisturizing effect of the makeup removing oil, which may be because the preparation method can affect the composition and content of active ingredients in the radix bupleuri extract, thereby affecting the moisturizing and repairing effect of the makeup removing oil.

[0116] Test example 4

[0117] Ten female volunteers and five male volunteers are selected to perform patch tests.

[0118] The makeup removing oil prepared in application example 1 is subjected to human skin closed test according to the Cosmetic Safety Technology Standard (2015 edition).

[0119] Operation steps: qualified patch testers are selected, and the test object is attached to the normal skin on the curved side of the forearm of the test subject by using the closed patch test method, and the amount is about 0.02g-0.03g. After 24 hours, the test object is removed, and the skin reaction is observed at 30min, 24h and 48h after removal, respectively.

[0120] Table 3: Reaction degree judgment standard of test site

[0121] Phenomenon Determination Score level No skin reaction - 0 Skin appears with faint red macule, no infiltration ± 1 Skin appears with red macule, infiltration, papule + 2 Skin appears with red macule, edema, papule, small water blister ++ 3 Skin appears with large water blister on red macule, edema +++ 4

[0122] Table 4: Patch test results

[0123]

[0124] The test results show that the composition prepared by the application has no obvious irritation and sensitization to the human body, that is, the safety performance is good.

[0125] Test example 5

[0126] The skin changes of the volunteers who continuously use the makeup removing oil prepared in application example 1 for 28 days are recorded and detected to explore the soothing and repairing effect of the composition and the makeup removing oil. The specific test method is as follows: the volunteers use the makeup removing oil in application example 1 once a day, 5g each time, continuously for 28 days, and the cheeks of the volunteers are selected as the test sites, and VISIA test is performed before use and on the 28th day of continuous use. The red area comparison of one volunteer before use and after continuous use for 28 days is as follows: Figure 2It can be seen from the contrast chart of the skin of the volunteers at 0 day and 28 days that the composition of the application added to the makeup remover oil can effectively improve the redness of the skin after continuous use for 28 days, which may be because the sophorolipid, magnolia alcohol and radix bupleuri extract have a synergistic effect, and by inhibiting the expression and activation of the TRPV1 receptor in the keratinocytes and nerve cells, the soothing and repairing effect is achieved.

[0127] Finally, it should be noted that the above examples are only used to illustrate the technical solutions of the present application and are not a limitation on the scope of protection of the present application. Although the present application has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solutions of the present application can be modified or replaced by equivalents without departing from the essence and scope of the technical solutions of the present application.

Claims

1. A composition containing sophorolipid and magnolol, characterized in that, The composition comprises sophorolipid, magnolol, and cynanchum atratum extract in a mass ratio of 1:0.5-2.5:0.8-1.2; The preparation method of the Baiwei extract is as follows: pulverize dried Baiwei to obtain Baiwei powder; mix Baiwei powder and extraction solvent, and sonicate to obtain extract; centrifuge the extract, collect the supernatant, and dry to obtain the Baiwei extract; The extraction solvent comprises betaine and lactic acid in a molar ratio of 1:1.3-1.8; the water content of the extraction solvent is 20-30 wt%.

2. The composition containing sophorolipid and magnolol as described in claim 1, characterized in that, The ratio of the powder to the extraction solvent is 1g:10-20mL.

3. The composition containing sophorolipid and magnolol as described in claim 1, characterized in that, The ultrasonic treatment has a power of 200-300W, a temperature of 50-60℃, and a time of 15-25min.

4. The composition containing sophorolipid and magnolol as described in claim 1, characterized in that, The composition comprises sophorolipid, magnolol, and cynanchum atratum extract in a mass ratio of 1:2:

1.

5. The method for preparing the composition containing sophorolipid and magnolol as described in any one of claims 1-4, characterized in that, The preparation method includes the following steps: mixing the raw materials evenly to obtain the composition.

6. The use of the composition containing sophorolipid and magnolol as described in any one of claims 1-4 in the preparation of cleaning products.

7. The application as described in claim 6, characterized in that, The composition containing sophorolipid and magnolol is used in cleaning products at an amount of 0.1-10 wt%.

8. The application as described in claim 6, characterized in that, The cleaning product is any one of the following: makeup remover oil, makeup remover balm, facial cleanser, makeup remover water, shampoo, shower gel, soap, and hand sanitizer.

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