Composition for improving stability of high-salt toothpaste and application thereof

Abstract

The invention relates to the field of daily chemicals, and discloses a composition for improving the stability of high-salt toothpaste and application of the composition. The composition is prepared from the following components in percentage by content in the high-salt toothpaste: 1.5 to 3 percent of foaming agent, 2 to 9 percent of functional salt, 0.05 to 2 percent of vitamin E derivative and 0.8 to 1.5 percent of essence, the mass ratio of the foaming agent to the functional salt to the vitamin E derivative to the essence is 1: (0.5-6): (0.03-1.5): (0.3-1). The invention finds that the stability of the high-salt toothpaste can be obviously improved by adding a specific variety of vitamin E derivatives into the high-salt toothpaste and mixing the vitamin E derivatives with the functional salt, the foaming agent and the essence at proper content and proper proportion.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of daily chemicals, in particular to a composition for improving the stability of high-salt toothpaste and application thereof. BACKGROUND

[0002] Toothpaste is an important oral cleaning and care product for cleaning teeth and maintaining oral hygiene, and is closely related to people's oral health. Ordinary toothpaste can help remove food debris and soft dirt through brushing, and freshen breath. If fluoride, anti-calculus ingredients, anti-dentin sensitivity ingredients, antibacterial plaque ingredients, and anti-gingivitis ingredients are added to the toothpaste, it can have the effects of preventing dental caries, anti-calculus, anti-tooth sensitivity, inhibiting dental plaque, and reducing gingivitis in addition to basic cleaning. These functional ingredients are usually sodium monofluorophosphate, pyrophosphate, potassium nitrate, strontium chloride, zinc citrate, and other functional salt ingredients. In order to ensure product stability, the addition amount of the above functional salt ingredients is usually small, generally not more than 2%. However, in order to achieve better functional performance, higher amounts of functional salt ingredients need to be added, and the amount exceeds 2% or even more. Higher salt content will have a great impact on the thickening system in the formula, especially the emulsified foaming system, thereby causing product stability problems such as separation and water outflow, resulting in product unqualification.

[0003] Currently, the industry usually improves system stability by increasing the amount of adhesive in the formula or reducing the amount of water in the formula, reducing the amount of foaming agent, adding a solubilizer, and repeatedly selecting the type of fragrance, but the above methods have poor applicability in high-salt formula systems. Specifically: (1) Conventional increase in the amount of adhesive or reduction in the amount of water will result in a thick paste or even too high a consistency, making it difficult to extrude, thereby affecting consumer experience, and the above methods are insufficient to solve the separation and water outflow problems caused by high-salt systems; (2) Reducing the amount of foaming agent will directly affect the foam experience during brushing, and increasing the amount of foaming agent will further exacerbate the separation and water outflow phenomenon; (3) Adding solubilizers such as hydrogenated castor oil and sorbitan oleate will bring obvious characteristic odors and strong defoaming phenomena, affecting the taste and foam experience during brushing. In addition, patent CN113318017A discloses a high-salt water-free toothpaste that can reduce gingivitis, which solves the problem of high-salt systems by using a water-free formula system (the water-free system does not have a separation problem), but significantly increases the cost of the formula.

[0004] In summary, it is necessary to develop a composition that can improve the separation and water outflow stability of high-salt toothpaste systems to solve the problem of easy separation and water outflow of high-salt toothpaste systems. SUMMARY

[0005] In order to solve the above technical problems, the present application provides a composition for improving the stability of high-salt toothpaste and application thereof. It is found in the present application that the addition of a specific type of vitamin E derivative in high-salt toothpaste, and the proper content and proper ratio of efficacy salt, foaming agent and fragrance, can significantly improve the stability of high-salt toothpaste.

[0006] The specific technical solutions of the present application include: In the first aspect, the present application provides a composition for improving the stability of high-salt toothpaste, which comprises the following raw materials in the content of high-salt toothpaste: foaming agent 1.5-3%, efficacy salt 2-9%, vitamin E derivative 0.06-2%, and fragrance 0.8-1.5%.

[0007] Among them, the mass ratio of the foaming agent, the efficacy salt, the vitamin E derivative and the fragrance = 1:0.5-6:0.03-1.5:0.3-1.

[0008] Vitamin E is an essential vitamin for the human body, which cannot be synthesized in the human body and needs to be taken from outside. Vitamin E has the functions of antioxidant, anti-inflammatory and promoting wound repair in the oral cavity, and is often used as a nutritional ingredient in toothpaste. Since vitamin E is easily oxidized and its activity is reduced, vitamin E derivatives (such as vitamin E acetate) are often used in toothpaste to replace vitamin E.

[0009] The applicant accidentally found during the experiment that the addition of a specific type and content of vitamin E derivative in a high-salt toothpaste system (efficacy salt content ≥ 2%) can effectively solve the problem of water separation of the high-salt system, and even in the case of reducing the amount of adhesive in toothpaste, the paste can still remain stable without separation, but if vitamin E is used instead, it cannot play a significant improvement role. Further analysis of the reasons, the present application found that part of the vitamin E derivative can be almost completely miscible with various types of fragrances, changing the HLB value of the overall fragrance oil phase, and forming a more stable emulsion system with the foaming agent in toothpaste, reducing the influence of the high-salt system on the emulsion system, thereby improving the separation problem of the high-salt toothpaste and improving the product stability.

[0010] In addition, the present application also finds that the high-salt toothpaste system has excellent stability of liquid separation and water discharge after the complexation of the foaming agent, the functional salt, and the vitamin E derivative and the essence in any content. The individual content of the foaming agent, the functional salt, and the vitamin E derivative and the essence in the formula and the mutual ratio among the four must be strictly limited. Specifically: (1) if the content of the vitamin E derivative in the system is small, the purpose of improving the water discharge cannot be achieved; on the contrary, if the content is too high, the defoaming phenomenon occurs, the foaming capacity of the foaming agent is inhibited, and thus the foam experience during brushing is reduced. (2) if the content of the functional salt or the content of the foaming agent in the system is too high, even if a large amount of the vitamin E derivative is added, the problem of paste liquid separation cannot be completely solved, and the content of the functional salt is too high to be completely dissolved during the preparation of the paste, thus forming some small particles or even agglomerates; if the content of the functional salt is too low, the expected efficacy performance of the product cannot be achieved, and if the content of the foaming agent is too low, the problem of too little foam during brushing occurs; and the essence is a necessary ingredient in toothpaste, and if the content of the essence is too low, the aroma cannot be fully expressed and some odors of raw materials cannot be covered, and if the content of the essence is too high, the mouth is easily irritated and the flavor of the product is changed. Therefore, the vitamin E derivative, the functional salt, the foaming agent, and the essence in the system need to be reasonably matched, so as to solve the problem of liquid separation of the high-salt system and ensure a good brushing experience.

[0011] In summary, the present application solves the problem of liquid separation of the high-salt system and ensures a good brushing experience by scientifically screening and matching the vitamin E derivative, the functional salt, the foaming agent, and the essence component, mutually dissolving the vitamin E derivative and the essence component, changing the HLB value of the essence oil phase, ensuring that the foaming agent can well emulsify the essence oil component when the content of the high-salt is high, achieving the effect of inhibiting the liquid separation and water discharge of the toothpaste, and ensuring that the content of the functional salt component is sufficient to achieve the product efficacy. The characteristic odor or strong defoaming adverse experience caused by conventional emulsifiers such as hydrogenated castor oil and sorbitan fatty acid esters is avoided.

[0012] As a preferred, the composition includes the following mass percentages of raw materials in the high-salt toothpaste: foaming agent 1.5-2.5%, functional salt 3-7%, vitamin E derivative 0.1-1%, and essence 0.8-1.5%. The mass ratio of the foaming agent, the functional salt, the vitamin E derivative, and the essence is 1:1-5:0.04-1.0:0.3-1.

[0013] The present application finds that the stability of the obtained high-salt toothpaste is better under the content of the above raw materials and the mutual ratio relationship.

[0014] As a preferred, the vitamin E derivative is one or more of vitamin E acetate, vitamin E phosphate, vitamin E nicotinate, and vitamin E succinate.

[0015] The present application finds through experiments that not all vitamin E derivatives have the effect of inhibiting the water separation of high-salt toothpaste. For example, the effect is relatively poor when vitamin E linoleate is used. Further, the present application finds that the above-mentioned specific vitamin E derivatives have good mutual solubility with different perfume components, can change the HLB value of the perfume oil phase, and ensure that the foaming agent can also better solubilize and emulsify the perfume oil components when the high-salt content is used, so as to achieve the effect of inhibiting the water separation of toothpaste.

[0016] As preferred, the foaming agent is an anionic surfactant and / or an amphoteric surfactant.

[0017] Further preferably, the foaming agent is one or more of sodium lauryl sulfate, cocamidopropyl betaine, lauroyl sarcosine, and sodium methyl cocoyl taurate.

[0018] The above-mentioned types of foaming agents are compounded with other components in the composition, and the effect is better.

[0019] As preferred, the efficacy salt includes one or more of anti-sensitivity ingredients, whitening anti-calculus ingredients, bacteriostatic ingredients, and anti-caries ingredients.

[0020] Further preferably, the anti-sensitivity ingredients include one or more of potassium nitrate and strontium chloride. The whitening anti-calculus ingredients include one or more of sodium pyrophosphate, sodium tripolyphosphate, sodium hexametaphosphate, and sodium phytate. The bacteriostatic ingredients include one or more of zinc citrate, zinc lactate, and zinc gluconate. The anti-caries ingredients include fluoride.

[0021] The above-mentioned types of efficacy salt are compounded with the foaming agent, vitamin E derivative, and perfume in the composition, and the effect is better.

[0022] As preferred, the perfume includes one or more of floral, fruity, mint, and herbaceous types.

[0023] The above-mentioned types of perfume are compounded with other components in the composition, and the effect is better.

[0024] In a second aspect, the present application provides use of the above-mentioned composition in the preparation of high-salt toothpaste.

[0025] In a third aspect, the present application provides a high-salt toothpaste, which, in addition to containing the above-mentioned composition, also includes the following raw materials in mass percentage: humectant 30-70%, abrasive 10-30, thickening agent 2-6%, glue powder 0.5-2.0%, sweetener 0.1-1%, appearance modifier 0.1-1%, and water.

[0026] The present application can further reduce the negative influence of other components in the system on the composition of the present application by optimizing the high-salt toothpaste formula, thereby more favorably enabling the present application to fully play a role in inhibiting the water separation of high-salt toothpaste.

[0027] Compared with the prior art, the present application has the following beneficial effects: (1) In high-salt toothpaste, the present application adds a specific type of vitamin E derivative, and optimizes the ratio of the vitamin E derivative, the functional salt, the foaming agent, and the fragrance component, so that the vitamin E derivative and the fragrance are fully miscible, the HLB value of the fragrance oil phase is changed, the foaming agent can better solubilize and emulsify the fragrance oil component even when the salt content is high, the effect of inhibiting water separation of toothpaste is achieved, and the sufficient use of the functional salt component to achieve product efficacy is ensured. Avoid the characteristic odor or strong defoaming adverse experience caused by conventional emulsifiers such as hydrogenated castor oil and sorbitan fatty acid esters.

[0028] (2) On the basis of solving the problem of water separation of high-salt toothpaste, the vitamin E derivative added in the present application can also improve the adaptability of high-salt toothpaste formula to different fragrances, thereby further improving the richness of taste. BRIEF DESCRIPTION OF DRAWINGS

[0029] Figure 1 Photos of samples after high-speed centrifugation of Examples 1-6 and Comparative Example 1-7.

[0030] Figure 2 Photos of samples after high-speed centrifugation of Examples 7-9 and Comparative Examples 8-10.

[0031] Figure 3 Photos of samples after high-speed centrifugation of Examples 10-16 and Comparative Example 11.

[0032] Figure 4 Photos of samples after high-speed centrifugation of Examples 17-21 and Comparative Examples 12-17. DETAILED DESCRIPTION

[0033] The present application will be further described below in conjunction with examples.

[0034] OVERALL EXAMPLE In a first aspect, a composition for improving the stability of high-salt toothpaste includes the following mass percentages of raw materials in the content in high-salt toothpaste: foaming agent 1.5-3%, functional salt 2-9%, vitamin E derivative 0.06-2%, and fragrance 0.8-1.5%. The mass ratio of the foaming agent, the functional salt, the vitamin E derivative, and the fragrance is 1:0.5-6:0.03-1.5:0.3-1.

[0035] In some preferred embodiments, the composition comprises the following mass percentages of raw materials: foaming agent 1.5-2.5%, efficacy salt 3-7%, vitamin E derivative 0.1-1%, and fragrance 0.8-1.5%, based on the content in high-salt toothpaste. The mass ratio of the foaming agent, efficacy salt, vitamin E derivative, and fragrance is 1:1-5:0.04-1.0:0.3-1.

[0036] In some preferred embodiments, the vitamin E derivative is one or more of vitamin E acetate, vitamin E phosphate, vitamin E nicotinate, and vitamin E succinate.

[0037] In some preferred embodiments, the foaming agent is an anionic surfactant and / or an amphoteric surfactant.

[0038] In some more preferred embodiments, the foaming agent is one or more of sodium lauryl sulfate, cocamidopropyl betaine, lauroyl sarcosinate, and sodium methyl cocoyl taurate.

[0039] In some preferred embodiments, the efficacy salt comprises one or more of an anti-sensitivity ingredient, a whitening anti-calculus ingredient, a bacteriostatic ingredient, and an anti-caries ingredient.

[0040] In some more preferred embodiments, the anti-sensitivity ingredient comprises one or more of potassium nitrate and strontium chloride. The whitening anti-calculus ingredient comprises one or more of sodium pyrophosphate, sodium tripolyphosphate, sodium hexametaphosphate, and sodium phytate. The bacteriostatic ingredient comprises one or more of zinc citrate, zinc lactate, and zinc gluconate. The anti-caries ingredient comprises fluoride.

[0041] In some preferred embodiments, the fragrance comprises one or more of a floral type, a fruity type, a minty type, and a herbaceous type.

[0042] In a second aspect, the composition is used for preparing high-salt toothpaste.

[0043] In a third aspect, a high-salt toothpaste comprises, in addition to the above-mentioned composition, the following mass percentages of raw materials: humectant 30-70%, abrasive 10-30, thickening agent 2-6%, gum powder 0.5-2.0%, sweetener 0.1-1%, appearance modifier 0.1-1%, and water.

[0044] In some preferred embodiments, the humectant comprises one or more of sorbitol, glycerin, polyethylene glycol, propylene glycol. The abrasives comprise one or more of silica, calcium phosphate, calcium carbonate. The thickening agents comprise one or more of thickening silica, polyquatemium. The gum powders comprise one or more of gum arabic, carrageenan, cellulose gum, guar gum. The sweeteners comprise one or more of steviol glycosides, xylitol, erythritol, sucralose, sodium saccharin. The appearance modifiers comprise one or more of pigments, titanium dioxide, pearl essence, color particles.

[0045] The following cases involve high-speed centrifugal test: toothpaste is high-speed centrifuged at 10000 rpm for 2 hours, and the state of the paste after centrifugation is observed. If a flowable liquid appears, it is determined to be watered out and unqualified.

[0046] The following cases involve tooth brushing test: after brushing teeth for 2 minutes in a conventional manner, the amount of toothpaste foam is felt.

[0047] The following cases involve paste appearance test: the toothpaste tube is cut open with scissors, and the appearance of the paste after sectioning is observed.

[0048] (1) The high-salt toothpaste formula of each embodiment and comparative example and the test results are shown in the following table (the content of each raw material in the table is in mass percent, %).

[0049] Table 1: Effect of vitamin E derivative in the system By Figure 1 Comparing Examples 1-6 and Comparative Examples 1-3 in Table 1, it can be seen that the vitamin E derivative can improve the watering problem of the high-salt system, but needs to be controlled within a reasonable range; for example, Comparative Example 1 (0) and Comparative Example 2 (0.05%), without or with a small amount of vitamin E derivative, cannot effectively improve the watering problem; while an excessive amount of vitamin E derivative, such as Comparative Example 3 (3%), can improve the watering problem, but at the same time, it also reduces the foam experience during brushing; and vitamin E cannot effectively improve the watering problem of the high-salt system, such as Comparative Example 4; in addition, vitamin E linoleate in Comparative Example 5 has poor improvement effect due to the lipophilicity of the oleate group; and non-ionic surfactants such as sorbitan oleate (Comparative Example 6) and hydrogenated castor oil 40 (Comparative Example 7) can also improve the watering problem, but have stronger defoaming effect and bring obvious odor (characteristic oil odor of sorbitan oleate and hydrogenated castor oil 40), which seriously affects the brushing experience.

[0050] Table 2: Effect of foaming agent in the system By Figure 2 And comparing Example 7-9 and Comparative Example 8-10 in Table 2, it can be seen that the effect of the amount of foaming agent in the system is particularly important. When the amount of foaming agent is too low, the water in the paste is not centrifuged out, such as Comparative Example 8 (1%), but the foam is very little when brushing teeth; when the amount of foaming agent is too high, although the foam is normal, the high or low amount of vitamin E derivative cannot solve the water out problem; and when the amount of foaming agent is in a reasonable range, the stability requirement can be met by reasonable matching of the amount, while ensuring the amount of foam when brushing teeth.

[0051] Table 3: Effect of efficacy salt in the system By Figure 3 And comparing Example 10-16 and Comparative Example 11 in Table 3, it can be seen that the higher the content of efficacy salt in the system, the more vitamin E derivative is needed; and when the content of efficacy salt is high, such as Example 15 and Example 16, although the centrifugal stability can be improved, incomplete dissolution of salt may also cause some small ions in the cross section of the paste, but the normally extruded paste has no obvious small particles; and when the content of efficacy salt is too high, the water out problem cannot be completely improved, and granulation and even rough paste are prone to occur.

[0052] Table 4: Effect of essence in the system By Figure 4 And comparing Example 17-21 and Comparative Example 12-18 in Table 4, it can be seen that different essences in the system also have different performances, such as in Comparative Example 12-16, Comparative Example 12 adopts essence 1 which performs normally, and the other four essences have the water out problem when centrifuged; by comparing Comparative Example 12 and Comparative Example 13, it is found that the system of essence 1 is better than the other four, but when the content of efficacy salt is increased, the water out problem still occurs. In Example 17-21, by matching an appropriate amount of vitamin E derivative in the system, the five essences can all adapt to the formula system.

[0053] In summary, in combination with the above examples and comparative examples, it is shown that the vitamin E derivative, efficacy salt, foaming agent, and essence in the composition need to be scientifically and reasonably matched, so as to solve the high-salt system liquid separation and water out problem and ensure a better brushing experience. And it can be clearly seen that the high-salt toothpaste adopting the composition of the present application can improve the easy liquid separation problem of the high-salt system, and improve the adaptability of the formula system to various essences, which can provide more taste choices for formula developers.

[0054] The raw materials and equipment used in the present application are common raw materials and equipment in the art unless otherwise specified; the methods used in the present application are conventional methods in the art unless otherwise specified.

[0055] The above is only a preferred embodiment of the present application, and does not limit the present application in any way. Any simple modification, change and equivalent transformation of the above embodiment based on the technical essence of the present application still falls within the protection scope of the technical solution of the present application.

Claims

1. A composition for improving the stability of high-salt toothpaste, characterized in that: The ingredients, by mass percentage, are included in high-salt toothpaste: Foaming agent 1.5-3%, Functional salt 2-9%, Vitamin E derivatives 0.06-2%, Fragrance 0.8-1.5%; The mass ratio of the foaming agent, functional salt, vitamin E derivative and fragrance is 1:0.5-6:0.03-1.5:0.3-1.

2. The composition according to claim 1, characterized in that: The ingredients, by mass percentage, are included in high-salt toothpaste: Foaming agent 1.5-2.5%, Functional salt 3-7%, Vitamin E derivatives 0.1-1%, Fragrance 0.8-1.5%; The mass ratio of the foaming agent, functional salt, vitamin E derivative and fragrance is 1:1-5:0.04-1.0:0.3-1.

3. The composition according to claim 1 or 2, characterized in that: The vitamin E derivative is one or more of vitamin E acetate, vitamin E phosphate, vitamin E nicotinate, and vitamin E succinate.

4. The composition according to claim 1 or 2, characterized in that: The foaming agent is an anionic surfactant and / or an amphoteric surfactant.

5. The composition according to claim 4, characterized in that: The foaming agent is one or more of sodium lauryl sulfate, cocamidopropyl betaine, lauroyl sarcosine, and sodium methyl cocoyl taurate.

6. The composition according to claim 1 or 2, characterized in that: The functional salt includes one or more of the following: anti-sensitivity ingredients, whitening and anti-tartar ingredients, antibacterial ingredients, and anti-caries ingredients.

7. The composition according to claim 6, characterized in that: The anti-allergy ingredient includes one or more of potassium nitrate and strontium chloride; and / or The whitening and anti-tartar ingredients include one or more of sodium pyrophosphate, sodium tripolyphosphate, sodium hexametaphosphate, and sodium phytate; and / or The antibacterial component includes one or more of zinc citrate, zinc lactate, and zinc gluconate; and / or The anti-caries ingredient includes fluoride.

8. The composition according to claim 1 or 2, characterized in that: The fragrance includes one or more of the following: floral, fruity, minty, and herbal.

9. Use of the composition according to any one of claims 1-8 in the preparation of high-salt toothpaste.

10. A high-salt toothpaste, characterized in that: In addition to the composition according to any one of claims 1-8, the composition further comprises the following raw materials in weight percentages: 30-70% humectant, 10-30% abrasive, 2-6% thickener, 0.5-2.0% adhesive powder, 0.1-1% sweetener, 0.1-1% appearance improver, and water.

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